butadienes

Summary

Summary: Four carbon unsaturated hydrocarbons containing two double bonds.

Top Publications

  1. ncbi Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes
    Deepanwita Prusty
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:46226-32. 2002
  2. pmc Increased thermostability of thylakoid membranes in isoprene-emitting leaves probed with three biophysical techniques
    Violeta Velikova
    Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Plant Physiol 157:905-16. 2011
  3. pmc Mitotic clonal expansion: a synchronous process required for adipogenesis
    Qi Qun Tang
    Department of Biological Chemistry, Division of Endocrinology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:44-9. 2003
  4. ncbi ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:478-85. 2002
  5. ncbi Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1
    K M Sutton
    Cell Growth Regulation and Angiogenesis Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, UK
    Oncogene 26:3920-9. 2007
  6. ncbi Physiological modeling of isoprene dynamics in exhaled breath
    Julian King
    Breath Research Institute, Austrian Academy of Sciences, Rathausplatz 4, A 6850 Dornbirn, Austria
    J Theor Biol 267:626-37. 2010
  7. pmc Isoprene produced by leaves protects the photosynthetic apparatus against ozone damage, quenches ozone products, and reduces lipid peroxidation of cellular membranes
    F Loreto
    Consiglio Nazionale delle Richerche, Istituto di Biochimica ed Ecofisiologia Vegetali, Rome, Italy
    Plant Physiol 127:1781-7. 2001
  8. ncbi Modeling the isoprene emission rate from leaves
    Russell K Monson
    School of Natural Resources and Environment and Laboratory for Tree Ring Research, University of Arizona, Tucson, Arizona 85721, USA
    New Phytol 195:541-59. 2012
  9. ncbi Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells
    Laure Emmanuelle Zaragosi
    Institut de Recherche, Signalisation, Biologie du Développement et Cander, UMR6543 Centre National de la Recerche Scientifique, Centre de Biochimie, Faculte des Sciences, Université Nice Sophia Antiplis, Nice, France
    Stem Cells 24:2412-9. 2006
  10. pmc Stabilization of thylakoid membranes in isoprene-emitting plants reduces formation of reactive oxygen species
    Violeta Velikova
    Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Plant Signal Behav 7:139-41. 2012

Detail Information

Publications292 found, 100 shown here

  1. ncbi Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes
    Deepanwita Prusty
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:46226-32. 2002
    ..Our results suggest that activation of the MEK/ERK signaling pathway during the initial 12 h of adipogenesis enhances the activity of factors that regulate both C/EBPalpha and PPARgamma expression...
  2. pmc Increased thermostability of thylakoid membranes in isoprene-emitting leaves probed with three biophysical techniques
    Violeta Velikova
    Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Plant Physiol 157:905-16. 2011
    ..These results contribute to our understanding of isoprene mechanism of action in plant protection against environmental stresses...
  3. pmc Mitotic clonal expansion: a synchronous process required for adipogenesis
    Qi Qun Tang
    Department of Biological Chemistry, Division of Endocrinology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:44-9. 2003
    ..These results show that MCE is a prerequisite for differentiation of 3T3-L1 preadipocytes into adipocytes...
  4. ncbi ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:478-85. 2002
    ..Activation of the ERK pathway in a subset of nociceptive spinal neurons contributes, therefore, to persistent pain hypersensitivity, possibly via transcriptional regulation of genes, such as prodynorphin and NK-1...
  5. ncbi Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1
    K M Sutton
    Cell Growth Regulation and Angiogenesis Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, UK
    Oncogene 26:3920-9. 2007
    ....
  6. ncbi Physiological modeling of isoprene dynamics in exhaled breath
    Julian King
    Breath Research Institute, Austrian Academy of Sciences, Rathausplatz 4, A 6850 Dornbirn, Austria
    J Theor Biol 267:626-37. 2010
    ....
  7. pmc Isoprene produced by leaves protects the photosynthetic apparatus against ozone damage, quenches ozone products, and reduces lipid peroxidation of cellular membranes
    F Loreto
    Consiglio Nazionale delle Richerche, Istituto di Biochimica ed Ecofisiologia Vegetali, Rome, Italy
    Plant Physiol 127:1781-7. 2001
    ..Irrespective of the mechanism, our results suggest that endogenous isoprene has an important antioxidant role in plants...
  8. ncbi Modeling the isoprene emission rate from leaves
    Russell K Monson
    School of Natural Resources and Environment and Laboratory for Tree Ring Research, University of Arizona, Tucson, Arizona 85721, USA
    New Phytol 195:541-59. 2012
    ..Where possible, we identify gaps in our knowledge that have prevented us from achieving a greater mechanistic foundation for the models, and we discuss the insight and data that must be gained to fill those gaps...
  9. ncbi Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells
    Laure Emmanuelle Zaragosi
    Institut de Recherche, Signalisation, Biologie du Développement et Cander, UMR6543 Centre National de la Recerche Scientifique, Centre de Biochimie, Faculte des Sciences, Université Nice Sophia Antiplis, Nice, France
    Stem Cells 24:2412-9. 2006
    ..Together, our data clearly identify the key function of FGF2 in the maintenance of self-renewal of adipose tissue-derived stem cells...
  10. pmc Stabilization of thylakoid membranes in isoprene-emitting plants reduces formation of reactive oxygen species
    Violeta Velikova
    Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Plant Signal Behav 7:139-41. 2012
    ..We present considerations that make the latter a more likely mechanism, under our experimental circumstances...
  11. pmc Isoprene emission from plants: why and how
    Thomas D Sharkey
    Department of Botany, University of Wisconsin Madison, Madison, WI 53706, USA
    Ann Bot 101:5-18. 2008
    ..Some, but not all, plants emit isoprene. Emission of the related monoterpenes is more universal among plants, but the amount of isoprene emitted from plants dominates the biosphere-atmosphere hydrocarbon exchange...
  12. ncbi Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells
    Dae Sik Kwon
    Department of Physiology, Medical Research Institute, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Pusan 602 739, Republic of Korea
    Eur J Cell Biol 85:1189-99. 2006
    ..Activation of these kinases may be involved in the repair process during ischemia/reperfusion...
  13. ncbi Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria
    Xu Dong Zhang
    Immunology and Oncology Unit, Room 443, David Maddison Clinical Sciences Building, Cnr King and Watt Streets, Newcastle, NSW 2300, Australia
    Oncogene 22:2869-81. 2003
    ....
  14. ncbi Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study
    J King
    University Clinic for Anesthesia, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Physiol Meas 31:1169-84. 2010
    ....
  15. pmc Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia
    S Namura
    Stroke and Brain Protection, Research Institute, and Department of Neurosurgery, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Proc Natl Acad Sci U S A 98:11569-74. 2001
    ..These results provide further evidence for the role of MEK/ERK activation in brain injury resulting from ischemia/reperfusion, and indicate that MEK inhibition may increase the resistance of tissue to ischemic injury...
  16. ncbi The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint
    Daisuke Seino
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya 663 8501, Japan
    Pain 123:193-203. 2006
    ..Thus, it is suggested that the activation of the P2X3 receptor is involved in the phosphorylation of ERK in DRG neurons and the mechanical hypersensitivity of the inflamed knee joint...
  17. ncbi Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways
    Pei Ni Chen
    Institute of Biochemistry, Chung Shan Medical University, No 110, Section 1, Chien Kuo N Road, Taichung 402, Taiwan
    Chem Biol Interact 156:141-50. 2005
    ..These findings suggested that the inhibition on MMP-2 and u-PA expression by silibinin may be through a suppression on ERK1/2 or Akt phosphorylation, which in turn led to the reduced invasiness of the cancer cells...
  18. pmc Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat
    Aida Maddahi
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    BMC Neurosci 10:56. 2009
    ..The formation of oedema and opening of the blood-brain barrier in stroke is associated with enhanced expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1)...
  19. ncbi MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia
    Marie Henriksson
    Division of Experimental Vascular Research, Department of Clinical Sciences in Lund, BMC A13, Lund University, Lund, 221 84 Sweden
    Exp Brain Res 178:470-6. 2007
    ..The vascular effects of U0126 provide new perspective on possible mechanisms of actions of MAPK inhibition in cerebral ischaemia...
  20. ncbi Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling
    Hideko Hayashi
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    Genes Cells 13:941-7. 2008
    ..Thus, our results demonstrate that the ERK pathway negatively modulates the PI3-kinase/Akt pathway in response to growth factor stimulation...
  21. ncbi Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation
    Hita Adwanikar
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Pain 111:125-35. 2004
    ....
  22. ncbi Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types
    Bettina A Dummler
    Department of Clinical Biochemistry, Glostrup Hospital, 2600 Glostrup, Denmark
    J Biol Chem 280:13304-14. 2005
    ....
  23. ncbi Transgenic, non-isoprene emitting poplars don't like it hot
    Katja Behnke
    Research Centre Karlsruhe, Institute for Meteorology and Climate Research IMK IFU, Kreuzeckbahnstr 19, 82467 Garmisch Partenkirchen, Germany
    Plant J 51:485-99. 2007
    ..In conclusion, using a molecular genetic approach, we show that down-regulation of isoprene emission affects thermotolerance of photosynthesis and induces increased energy dissipation by NPQ pathways...
  24. ncbi Biochemistry and physiology of foliar isoprene production
    B A Logan
    Dept of Biology, Bowdoin College, Brunswick, ME 04011, USA
    Trends Plant Sci 5:477-81. 2000
    ....
  25. ncbi Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
    H Kurokawa
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 60:5887-94. 2000
    ..Thus, blockade of HER2 and MAPK signaling may enhance tamoxifen action and abrogate antiestrogen resistance in human breast cancer...
  26. ncbi [Effect on apoptosis of anterior pituitary induced by cadmium chloride and its relations with p38 MAPK & ERK1/2 passway]
    Xing fen Yang
    Center for Disease Control and Prevention of Guangdong Province, Guangzhou 510300, China
    Wei Sheng Yan Jiu 34:681-4. 2005
    ..To study the effects of cadmium chloride on anterior pituitary and the relation between p38 MAPK & ERK1/2 pathway and apoptosis induced by cadmium chloride...
  27. ncbi A comparison of male-mediated effects in rats and mice exposed to 1,3-butadiene
    D Anderson
    BIBRA International, Carshalton, Surrey, UK
    Mutat Res 397:77-84. 1998
    ..The differences observed between the rat and mouse studies would confirm the greater sensitivity to 1,3-butadiene of the mouse by comparison with the rat as reported by other workers for other parameters...
  28. pmc Induction of a longer term component of isoprene release in darkened aspen leaves: origin and regulation under different environmental conditions
    Bahtijor Rasulov
    Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    Plant Physiol 156:816-31. 2011
    ..These metabolites are converted to isoprene as soon as ATP and NADPH become available, likely by dark activation of chloroplastic glycolysis and chlororespiration...
  29. pmc 1,3-Butadiene: Biomarkers and application to risk assessment
    James A Swenberg
    Department of Environmental Sciences and Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27559, USA
    Chem Biol Interact 192:150-4. 2011
    ..These data provide a scientific basis for improved risk assessment of BD...
  30. ncbi A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport
    Rama Soundararajan
    Division of Nephrology, Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0532, USA
    J Biol Chem 280:39970-81. 2005
    ..These observations suggest a novel link between GILZ and regulation of epithelial sodium transport through modulation of ERK signaling and could represent an important pathway for mediating aldosterone actions in health and disease...
  31. ncbi A follow-up study of mortality among women in the North American synthetic rubber industry
    Nalini Sathiakumar
    Department of Epidemiology, School of Public Health, The University of Alabama at Birmingham, Birmingham, Ala, USA
    J Occup Environ Med 51:1314-25. 2009
    ..To evaluate mortality from cancer and other diseases among 4863 women employed at eight North American styrene-butadiene rubber plants. Cancers of the lymphohematopoietic tissues, breast, and ovary were of strongest a priori interest...
  32. ncbi Suppression of pro-metastasis phenotypes expression in malignant pleural mesothelioma by the PI3K inhibitor LY294002 or the MEK inhibitor UO126
    George W Cole
    Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Anticancer Res 26:809-21. 2006
    ....
  33. ncbi Influence of smoking charcoal filter tipped cigarettes on various biomarkers of exposure
    Gerhard Scherer
    ABF Analytisch biologisches Forschungslabor GmbH, Muenchen, Germany
    Inhal Toxicol 18:821-9. 2006
    ....
  34. pmc Enhancing isoprene production by genetic modification of the 1-deoxy-d-xylulose-5-phosphate pathway in Bacillus subtilis
    Junfeng Xue
    BioProducts, Sciences and Engineering Laboratory, Washington State University Tri Cities, 2710 University Dr, Richland, WA 99354 1671, USA
    Appl Environ Microbiol 77:2399-405. 2011
    ..In addition, induction and repression effects are independent of SigB, which is the general stress-responsive alternative sigma factor of Gram-positive bacteria...
  35. ncbi U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways
    H Fukazawa
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan
    Cancer Res 60:2104-7. 2000
    ..Simultaneous blockade of more than one signal transduction pathway by combining selective inhibitors might be effective in suppressing uncontrolled tumorigenic growth...
  36. ncbi Improvement in neurological outcome and abolition of cerebrovascular endothelin B and 5-hydroxytryptamine 1B receptor upregulation through mitogen-activated protein kinase kinase 1/2 inhibition after subarachnoid hemorrhage in rats
    Carl Christian Larsen
    Departments of Neurosurgery, Glostrup University Hospital, Glostrup, Denmark
    J Neurosurg 114:1143-53. 2011
    ..The aim in the present study was to determine whether treatment with the MEK1/2 inhibitor U0126 can prevent cerebrovascular receptor upregulation and improve functional outcome after experimental SAH in rats...
  37. ncbi Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    J Biol Chem 278:8904-12. 2003
    ..Furthermore, we show that GDF-15 prevented generation of reactive oxygen species, a known activator of ERK. Together, our data suggest that GDF-15 prevents apoptosis in CGN by activating Akt and inhibiting endogenously active ERK...
  38. pmc Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway
    Koichi Inoue
    Robert S Dow Neurobiology Laboratories, Legacy Research, 1225 NE 2nd Ave Portland, OR 97232, USA
    Cardiovasc Res 83:547-57. 2009
    ..The presence and potential function of transient receptor potential melastatin 7 (TRPM7), a Ca2+-permeable non-selective cation channel of the TRP channel superfamily in human vascular endothelial cells, were examined...
  39. ncbi On-line analysis of the (13)CO(2) labeling of leaf isoprene suggests multiple subcellular origins of isoprene precursors
    T Karl
    Institut fur Ionenphysik, Universitat Innsbruck, Technikerstrasse 25, 6020 Innsbruck Austria
    Planta 215:894-905. 2002
    ..The data obtained shed light on the half-lives of photosynthetic metabolites, exchanges of carbon between cellular pools, and suggest multiple origins of isoprene precursors in leaves...
  40. ncbi Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1
    Stephan Gysin
    Cancer Research Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco Comprehensive Cancer Center, San Francisco, California 94115, USA
    Cancer Res 65:4870-80. 2005
    ..Moreover, these data suggest that pharmacologic inhibition of the RAF-->MEK-->ERK signaling pathway alone might tend to have a cytostatic, as opposed to a cytotoxic, effect on pancreatic cancer cells...
  41. ncbi New particle formation in forests inhibited by isoprene emissions
    Astrid Kiendler-Scharr
    Institut ICG 2, Troposphäre
    Nature 461:381-4. 2009
    ....
  42. pmc Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway
    Honglin Luo
    Department of Pathology and Laboratory Medicine, McDonald Research Laboratories The iCAPTURE Center, St Paul s Hospital Providence Health Care University of British Columbia, Vancouver, British Columbia, Canada
    J Virol 76:3365-73. 2002
    ..Our findings demonstrate coxsackievirus takeover of a particular host signaling mechanism and uncover a prospective approach to stymie virus spread and preserve myocardial integrity...
  43. ncbi Response of isoprene emission and carbon metabolism to drought in white poplar (Populus alba) saplings
    Federico Brilli
    CNR Istituto di Biologia Agroambientale e Forestale, Via Salaria km 29 300, 00016 Monterotondo Scalo Roma, Italy
    New Phytol 175:244-54. 2007
    ..Isoprene emission was likely controlled at the posttranscriptional level under severe drought...
  44. ncbi Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms
    Kang Lu
    Department of Neurosurgery, E Da Hospital, I Shou University, Kaohsiung 824, Taiwan
    J Neurochem 114:237-46. 2010
    ..Future research should focus on the possible cross-talk between the MEK/ERK pathway and the NF-kappaB transcriptional cascade...
  45. pmc Isoprene increases thermotolerance of fosmidomycin-fed leaves
    T D Sharkey
    Department of Botany, University of Wisconsin, 430 Lincoln Drive, Madison, Wisconsin 53706, USA
    Plant Physiol 125:2001-6. 2001
    ..The effect may be a general hydrocarbon effect and related to the double bonds in the isoprene molecule...
  46. ncbi Increased CO2 uncouples growth from isoprene emission in an agriforest ecosystem
    Todd N Rosenstiel
    Department of Environmental, Population, and Organismic Biology, University of Colorado, Boulder, Colorado 80309, USA
    Nature 421:256-9. 2003
    ..Our results highlight the potential for uncoupling isoprene emission from biomass accumulation in an agriforest species, and show that negative air-quality effects of proliferating agriforests may be offset by increases in CO2...
  47. ncbi Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
    Keiran S M Smalley
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cancer Ther 5:1136-44. 2006
    ..It is further suggested that BRAF mutational status is not predictive of response to MEK inhibition under three-dimensional culture conditions...
  48. ncbi MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma
    Francesco Marampon
    Department of Experimental Medicine, University of L Aquila, Via Vetoio Coppito II, 67100 L Aquila, Italy
    Mol Cancer Ther 8:543-51. 2009
    ..Thus, MEK inhibitors may be investigated for a signal transduction-based targeting of the c-Myc as a therapeutic strategy in ERMS...
  49. pmc Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage
    Frederic Bost
    INSERM E9911 and IFR50, Faculte de Medecine, Universite de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France
    Biochem J 361:621-7. 2002
    ....
  50. ncbi Inhibition of phosphatidylinositol-3-kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPRas mouse model
    Barbara Bedogni
    Division of Radiation and Cancer Biology, 269 Campus Drive, CCSR S 1230, Stanford 94305, CA, USA
    Mol Cancer Ther 5:3071-7. 2006
    ....
  51. pmc Ozone quenching properties of isoprene and its antioxidant role in leaves
    F Loreto
    Consiglio Nazionale delle Ricerche, Istituto di Biochimica ed Ecofisiologia Vegetali, Via Salaria Km 29, 300, 00016 Monterotondo Scalo, Roma, Italy
    Plant Physiol 126:993-1000. 2001
    ..Irrespective of the mechanism, isoprene is one of the most effective antioxidants in plants...
  52. pmc Natural abundance carbon isotope composition of isoprene reflects incomplete coupling between isoprene synthesis and photosynthetic carbon flow
    Hagit P Affek
    Department of Environmental Sciences and Energy Research, Weizmann Institute of Science, Rehovot 76100, Israel
    Plant Physiol 131:1727-36. 2003
    ....
  53. pmc The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish
    Thomas A Hawkins
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    BMC Dev Biol 8:42. 2008
    ....
  54. ncbi Regulation of bidirectional melanosome transport by organelle bound MAP kinase
    Sean W Deacon
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Curr Biol 15:459-63. 2005
    ..We propose that signaling of organelle bound ERK is a key pathway that regulates bidirectional, microtubule-based melanosome transport...
  55. pmc Temperature response of isoprene emission in vivo reflects a combined effect of substrate limitations and isoprene synthase activity: a kinetic analysis
    Bahtijor Rasulov
    Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    Plant Physiol 154:1558-70. 2010
    ..These results have important implications for the development of process-based models of isoprene emission...
  56. ncbi Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells
    June Helen Myklebust
    Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Exp Hematol 30:990-1000. 2002
    ..The aim of this was to examine the relative involvement of PI3K in the development of glycophorin A (GPA)(+) erythroid cells from normal hematopoietic progenitor cells...
  57. pmc Postillumination isoprene emission: in vivo measurements of dimethylallyldiphosphate pool size and isoprene synthase kinetics in aspen leaves
    Bahtijor Rasulov
    Department of Plant Physiology, University of Tartu, 51010 Tartu, Estonia
    Plant Physiol 149:1609-18. 2009
    ....
  58. ncbi A conserved role for the MEK signalling pathway in neural tissue specification and posteriorisation in the invertebrate chordate, the ascidian Ciona intestinalis
    Clare Hudson
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS INSERM Universite de la Mediterranee AP de Marseille, Parc Scientifique de Luminy, Case 907, 13288, Marseille Cedex 9, France
    Development 130:147-59. 2003
    ..Altogether, the MEK signalling pathway appears to play evolutionary conserved roles in these processes in ascidians and vertebrates, suggesting that this may represent an ancestral chordate strategy...
  59. pmc Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury
    Maaike Alderliesten
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Am J Pathol 171:452-62. 2007
    ....
  60. pmc Ethanol-TGFalpha-MEK signaling promotes growth of human hepatocellular carcinoma
    Matthew Hennig
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Surg Res 154:187-95. 2009
    ..The effects of ethanol on extracellular signal-regulated kinase (ERK) activation, transforming growth factor alpha (TGF-alpha), and HCC growth were examined in this study...
  61. ncbi Valence shell electronic spectroscopy of isoprene studied by theoretical calculations and by electron scattering, photoelectron, and absolute photoabsorption measurements
    G Martins
    Laboratório de Colisões Atómicas e Moleculares, CEFITEC, Departamento de Fisica, FCT, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
    Phys Chem Chem Phys 11:11219-31. 2009
    ..The calculations are compared with the He(i) photoelectron spectrum (8 to 17 eV) and new vibrational structure is observed in the first photoelectron band...
  62. ncbi Aggravation of necrotic death of glucose-deprived cells by the MEK1 inhibitors U0126 and PD184161 through depletion of ATP
    Hong Wa Yung
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochem Pharmacol 68:351-60. 2004
    ..Thus, the MEK1/ERK signalling pathway may modulate ATP synthase function, and its inhibition may cause cells unable to perform glycolysis to die by necrosis...
  63. ncbi 1,3-Butadiene: I. Review of metabolism and the implications to human health risk assessment
    Christopher R Kirman
    Summit Toxicology, Orange, Ohio 44022, USA
    Crit Rev Toxicol 40:1-11. 2010
    ..A quantitative risk assessment of BD needs to reflect these species differences and sources of nonlinearity if it is to reflect the current understanding of the disposition of BD...
  64. ncbi Phytoplankton and cloudiness in the Southern Ocean
    Nicholas Meskhidze
    School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Science 314:1419-23. 2006
    ..Model simulations support this hypothesis, indicating that 100% of the observed changes in cloud properties can be attributed to the isoprene secondary organic aerosol...
  65. ncbi Genetic structure and regulation of isoprene synthase in Poplar (Populus spp.)
    Claudia E Vickers
    Department of Biological Sciences, Essex University, Colchester C043SQ, UK
    Plant Mol Biol 73:547-58. 2010
    ..No thylakoid isoforms could be identified in Populus alba or in Salix babylonica. Together, these data show that control of isoprene emission at the genetic level is far more complicated than previously assumed...
  66. ncbi A chronic reference value for 1,3-butadiene based on an updated noncancer toxicity assessment
    Roberta L Grant
    Toxicology Division, Texas Commission on Environmental Quality, Austin, Texas 78711 3087, USA
    J Toxicol Environ Health B Crit Rev 13:460-75. 2010
    ..2. The chronic ReV value, along with a unit risk factor developed by the TCEQ, will be used to evaluate ambient air monitoring data so that the general public is protected against adverse health effects from chronic exposure to BD...
  67. ncbi Enhanced phosphorylation of MAPKs by NE promotes TNF-α production by macrophage through α adrenergic receptor
    Jun Long Huang
    Department of Military Nautical Medicine, Laboratory of Stress Medicine, Faculty of Naval Medicine, Second Military Medical University, Xiangyin Road 800, Shanghai 200433, People s Republic of China
    Inflammation 35:527-34. 2012
    ..Our results provide the evidence of a relationship between stress and diseases, as well as the mechanism by which stress induces or affects the inflammation-related diseases...
  68. ncbi 1,3-Butadiene exposure and cardiovascular disease
    Arthur Penn
    Department of Comparative Biomedical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA 70803, United States
    Mutat Res 621:42-9. 2007
    ..The potential role of BD in the known atherosclerotic effects of environmental tobacco smoke as well as correlations between polymorphisms in BD phase II enzymes and development of atherosclerosis are presented...
  69. ncbi Quantification of trans-1,4-polyisoprene in Eucommia ulmoides by fourier transform infrared spectroscopy and pyrolysis-gas chromatography/mass spectrometry
    Shinya Takeno
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biosci Bioeng 105:355-9. 2008
    ..We successfully applied the extraction/quantification method for study of seasonal changes in EU-rubber content and molecular weight distribution...
  70. ncbi The expression and activation of ERK/MAPK pathway in human esophageal cancer cell line EC9706
    Shu Tao Zheng
    Medical Research Center, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, 830054, Xinjiang Uygur Autonomous Region, People s Republic of China
    Mol Biol Rep 38:865-72. 2011
    ..Moreover, the effective interference target sequence was screened out in a transient transfection manner. MTT experiment showed that ERK2 is more important than ERK1 in the proliferation of EC9706 cells...
  71. pmc PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1α expression in MCF-7 breast cancer cells
    Jun Du
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    PLoS ONE 6:e25213. 2011
    ..Hypoxia-inducible factor 1 (HIF-1α) expression induced by hypoxia plays a critical role in promoting tumor angiogenesis and metastasis. However, the molecular mechanisms underlying the induction of HIF-1α in tumor cells remain unknown...
  72. ncbi Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma
    Toru Mukohara
    Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Oncology 68:500-10. 2005
    ..Furthermore, combinations of growth factor and signal transduction inhibitors may be needed to inhibit the growth of the majority of MPM cell lines, and therefore patients with MPM...
  73. pmc Erk1/2 mediates leptin receptor signaling in the ventral tegmental area
    Richard Trinko
    Division of Molecular Psychiatry, Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e27180. 2011
    ..These data demonstrate that pERK1/2 may have a critical role in mediating both the electrophysiogical and behavioral effects of leptin receptor signaling in the VTA...
  74. ncbi In-situ chemical analyses of trans-polyisoprene by histochemical staining and Fourier transform infrared microspectroscopy in a rubber-producing plant, Eucommia ulmoides Oliver
    Takeshi Bamba
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Planta 215:934-9. 2002
    ....
  75. pmc Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts
    Sangmin Kim
    Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Institute of Dermatological Science, Seoul National University, Seoul, Korea
    Exp Mol Med 42:38-46. 2010
    ..Taken together, we suggest that the induction of TIMP-2 by cholesterol depletion leads to the conversion of proMMP-2 (72 kD) into active MMP-2 (64 kD) in human dermal fibroblasts...
  76. pmc p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells
    Carmela Ciccarelli
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Mol Cancer 4:41. 2005
    ....
  77. ncbi Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body
    K Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Neuroscience 126:1011-21. 2004
    ....
  78. ncbi Does isoprene protect plant membranes from thermal shock? A molecular dynamics study
    Magdalena E Siwko
    Laboratory of Lipids and Liposomes, Institute of Biochemistry and Molecular Biology, University of Wroclaw, Przybyszewskiego 63 77, 51 148 Wroclaw, Poland
    Biochim Biophys Acta 1768:198-206. 2007
    ..Furthermore it provides a clear mechanistic picture as to why plants specifically utilize isoprene for this purpose...
  79. ncbi Sites and mechanisms for uptake of gases and vapors in the respiratory tract
    M A Medinsky
    ToxCon, 5505 Frenchman s Creek Dr, Durham, NC 27713, USA
    Toxicology 160:165-72. 2001
    ....
  80. pmc Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis
    Mattijs K Julsing
    Department of Pharmaceutical Biology, Graduate School for Drug Exploration GUIDE, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Appl Microbiol Biotechnol 75:1377-84. 2007
    ..subtilis...
  81. ncbi Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway
    Hidesuke Fukazawa
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Mol Cancer Ther 1:303-9. 2002
    ..Inhibitors of MEK-ERK and mTOR-p70(S6K) pathways may provide a therapeutic strategy to selectively target neoplasms proliferating at ectopic locations, with acceptable effects on normal cells in their proper tissue context...
  82. ncbi Isoprene synthase expression and protein levels are reduced under elevated O3 but not under elevated CO2 (FACE) in field-grown aspen trees
    Carlo Calfapietra
    Department of Forest Environment and Resources DISAFRI, University of Tuscia, Via S Camillo De Lellis snc, 01100 Viterbo, Italy
    Plant Cell Environ 30:654-61. 2007
    ..However, the data indicated that other mechanisms also contributed to the observed strong inhibition of isoprene emission under elevated O(3)...
  83. ncbi Butadiene production process overview
    Wm Claude White
    Lyondell Chemical Company, 1221 McKinney, One Houston Center, Houston, TX 77010, USA
    Chem Biol Interact 166:10-4. 2007
    ..Other major butadiene derivatives are acrylonitrile-butadiene-styrene (ABS) and styrene butadiene latex (about 24% of demand combined)...
  84. ncbi Metabolism of 1,3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats
    Johannes Georg Filser
    Institute of Toxicology, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    Chem Biol Interact 166:93-103. 2007
    ..At higher BD concentrations EBD blood concentrations decreased again. This picture probably results from a competitive inhibition of the EBD producing CYP450 by BD, which occurs in both species...
  85. ncbi Isoprene emission rates under elevated CO2 and O3 in two field-grown aspen clones differing in their sensitivity to O3
    Carlo Calfapietra
    CNR Istituto di Biologia Agroambientale e Forestale, Via Salaria Km 29 300 00016 Monterotondo Scalo Roma, Italy
    New Phytol 179:55-61. 2008
    ....
  86. pmc Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation
    Melissa Goggin
    Masonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Res 69:2479-86. 2009
    ..Furthermore, a rat model of sensitivity to BD may be more appropriate than a mouse model for assessing human risk associated with BD exposure, because rats and humans seem to be similar with respect to DEB formation...
  87. ncbi DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene
    J A Swenberg
    Department of Environmental Sciences and Engineering, University of North Carolina, Campus Box 7400, Chapel Hill, NC 27599, USA
    Mutat Res 464:77-86. 2000
    ..Effects of both exogenous and endogenous DNA adducts need to be factored into the interpretation of chemical exposures...
  88. ncbi Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade
    S Pleschka
    , , , D-35392 Giessen, Germany
    Nat Cell Biol 3:301-5. 2001
    ..Thus, signalling through the mitogenic cascade seems to be essential for virus production and RNP export from the nucleus during the viral life cycle...
  89. ncbi Ambient air concentrations, source profiles, and source apportionment of 71 different C2-C10 volatile organic compounds in urban and residential areas of Finland
    Heidi Hellén
    Finnish Meteorological Institute, Erik Palménin aukio 1, 00560 Helsinki, Finland
    Environ Sci Technol 40:103-8. 2006
    ..g., benzene)...
  90. ncbi Mechanical strain and estrogen activate estrogen receptor alpha in bone cells
    H L Jessop
    Department of Veterinary Basic Sciences, The Royal Veterinary College, London, United Kingdom
    J Bone Miner Res 16:1045-55. 2001
    ..Reduced availability of this pathway when estrogen levels are reduced could explain diminished effectiveness of mechanically related control of bone architecture after the menopause...
  91. pmc PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior
    Yu Fu
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Mol Pain 4:26. 2008
    ..The data suggest that in the amygdala PKA and ERK, but not PKC, contribute to pain-related synaptic facilitation and behavior by increasing NMDA receptor function through independent signaling pathways...
  92. pmc Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression
    Haoming Chen
    Department of Biochemistry, Medical College of Georgia, Augusta, Georgia, USA
    Cancer Res 69:9228-35. 2009
    ..Our study suggests that the ERK pathway regulates breast cancer cell migration by maintaining slug expression...
  93. ncbi Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy
    Miguel A Frias
    Division of Endocrinology, Diabetology and Nutrition, University Hospital, 24, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Cardiovasc Res 73:57-65. 2007
    ....
  94. ncbi The enemy at the gates? DNA adducts as biomarkers of exposure to exogenous and endogenous genotoxic agents
    David E G Shuker
    Department of Chemistry, The Open University, Walton Hall, Milton Keynes, UK
    Toxicol Lett 134:51-6. 2002
    ..DNA adducts may also be useful in identifying no-exposure levels in risk assessment of low-level environmental exposures such as 1,3-butadiene (BD)...
  95. ncbi Induction of poplar leaf nitrate reductase: a test of extrachloroplastic control of isoprene emission rate
    T N Rosenstiel
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA
    Plant Biol (Stuttg) 6:12-21. 2004
    ..Cytosolic competition for PEP is a major regulator of chloroplast DMAPP supply, and we offer a new "safety valve" hypothesis to explain why plants emit isoprene...
  96. ncbi Isoprene synthesis protects transgenic tobacco plants from oxidative stress
    Claudia E Vickers
    Department of Biological Sciences, Essex University, Wivenhoe Park, Colchester, England C043SQ, UK
    Plant Cell Environ 32:520-31. 2009
    ..These results demonstrate that endogenously produced isoprene provides protection from oxidative damage...
  97. ncbi Susceptibility to cell death induced by blockade of MAPK pathway in human colorectal cancer cells carrying Ras mutations is dependent on p53 status
    Zhen Wang
    Laboratory of Molecular Pharmacology, Genome Institute of Singapore, Genome Building, 02 01, 60 Biopolis Street, Singapore 138672, Singapore
    Biochem Biophys Res Commun 322:609-13. 2004
    ....
  98. ncbi Isoprene emission from a subarctic peatland under enhanced UV-B radiation
    Päivi Tiiva
    Department of Environmental Science, University of Kuopio, PO Box 1627, FI 70211 Kuopio, Finland
    New Phytol 176:346-55. 2007
    ..Warming of the Arctic together with enhanced UV-B radiation may substantially increase the emissions...
  99. ncbi Prolonged extracellular signal-regulated kinase 1/2 activation during fibroblast growth factor 1- or heregulin beta1-induced antiestrogen-resistant growth of breast cancer cells is resistant to mitogen-activated protein/extracellular regulated kinase kina
    Jaideep V Thottassery
    Biochemistry and Molecular Biology Department, Drug Discovery Division, Southern Research Institute, University of Alabama at Birmingham Comprehensive Cancer Center, USA
    Cancer Res 64:4637-47. 2004
    ..Therefore, therapy combining antiestrogens and MEK inhibitors may be ineffective in some antiestrogen-resistant estrogen receptor-positive breast cancers...
  100. ncbi RNAi-mediated suppression of isoprene biosynthesis in hybrid poplar impacts ozone tolerance
    Katja Behnke
    Research Centre Karlsruhe GmbH, Institute for Meteorology and Climate Research, 82467 Garmisch Partenkirchen, Germany
    Tree Physiol 29:725-36. 2009
    ....
  101. ncbi Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway
    Akihiro Iwabu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 279:14551-60. 2004
    ..Hence, we identify here a new pathway helping to govern cell motility, with PLC signaling playing a role in activation of PKCdelta to promote the acute phase of EGF-induced MLC activation...

Research Grants62

  1. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans. ..
  2. DNA cross-linking by diepoxybutane
    Natalia Y Tretyakova; Fiscal Year: 2013
    ..PERFORMANCE SITE(S) (organization, city, state) The Cancer Center, University of Minnesota Minneapolis, Minnesota ..
  3. CHARACTERIZATION OF NOVEL BUTADIENE-INDUCED PUTATIVE p53 TARGET GENES
    Perpetua M Muganda; Fiscal Year: 2010
    ..This knowledge will have an important vertical impact on butadiene risk assessment, as well as on the design of better means of therapeutic intervention after butadiene exposure. ..
  4. Genes, genomes, and genotoxicity: in vivo epigenetic toxicology of 1,3-butadiene
    Ivan Rusyn; Fiscal Year: 2013
    ....
  5. Early Life Exposures to Air Toxics and the Risk of Early Childhood Leukemia
    Elaine Symanski; Fiscal Year: 2013
    ....
  6. Role of Rev1 in error-free replication of DNA damage and in mutation prevention
    Satya Prakash; Fiscal Year: 2012
    ..The proposed studies will examine the role of Rev1 DNA polymerase in promoting error-free replication through DNA lesions. ..
  7. Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking
    Stephen S Hecht; Fiscal Year: 2013
    ..The unique combination of expertise in this program project forms a powerful team arguably unmatched in its ability to address mechanisms of lung cancer development in smokers from different ethnic/racial groups. ..
  8. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Peter Guengerich; Fiscal Year: 2013
    ..Collectively these studies should provide new mechanistic insight into the toxicity and carcinogenicity of these adducts and important information that may alter paradigms in risk assessment. ..
  9. PLASMA PROTEINS: MARKERS OF CHEMICAL EXPOSURE
    GHULAM ANSARI; Fiscal Year: 1991
    ..The proposed screening and chemoprevention studies to be conducted in China will be a collaborative project by investigators in China and the United States...
  10. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ....
  11. Mid-IR LIDAR for Detecting Volatile Organic Compounds
    IGOR E TROFIMOV; Fiscal Year: 2010
    ..They can also be deployed in manufacturing facilities that are subject to occupational health and safety regulations. Long-time stationary deployments can also be used for toxicology studies over extended time periods. ..
  12. Role of human DNA polymerase iota in replicative bypass of DNA lesions
    Aneel K Aggarwal; Fiscal Year: 2013
    ..An error-free mode of TLS would be in keeping with a role for Pol? in suppression of carcinogenesis that would otherwise result from exposure to environmental and chemical carcinogens. ..
  13. Studies of Chemical Disposition in Animals
    GLENN I SIPES; Fiscal Year: 2009
    ..vivo;In vitro;Radiolabeled compounds;Dermal;Gavage;IV;Inhalation;Mass balance;Ionic liquids;tetrabromobisphenol A;tetrabromobisphenol A-2,3 dibromopropyl ether;ionic liquids ..
  14. Innovations to Inform Occupational Disease Etiology Using Biomonitoring Methods
    JO ANNA SHIMEK; Fiscal Year: 2009
    ..Finally, a biomarker of susceptibility will be analyzed using a mutagen sensitivity assay for these compounds, and results will be correlated with the relative cumulative exposure scores. ..
  15. Serum Inhibin B Levels in Male Polymer Production Worker
    Richard Lewis; Fiscal Year: 2000
    ..We believe that this investigation is novel and has the potential to be the foundation for meaningful medical surveillance for male reproductive toxicity. ..
  16. METABOLIC BASIS OF CONJUGATED DIENES TOXICITY
    ADNAN ELFARRA; Fiscal Year: 1992
    ..This will include an investigation of the possible inactivation of enzymes involved in the bioactivation of conjugated dienes by the generated reactive metabolites...
  17. CASE CONTROL STUDY OF CANCER IN SYNTHETIC RUBBER WORKER
    Genevieve Matanoski; Fiscal Year: 1991
    ....
  18. METAL CATALYSED ASYMMETRIC DIELS-ALDER REACTIONS
    Brice Bosnich; Fiscal Year: 1991
    ..to investigate the classical Diels-Alder partners, alpha-beta- unsaturated esters, aldehydes and ketones with butadienes and cyclopentadiene. The emphasis is on the nature of the catalysis...
  19. SELECTIVE REAL-TIME DETECTION OF OLEFIN GASES AND VAPORS
    EDWARD ZELLERS; Fiscal Year: 1991
    ..Instrument performance will be evaluated using dynamic test atmospheres with respect to several relevant operating parameters...
  20. COLLABORATIVE STUDY OF 1,3 BUTADIENE BIOMARKERS
    Thomas Smith; Fiscal Year: 2002
    ..05) to detect a q10 percent difference in slopes among subgroups. Biomarkers will be compared for background levels, biases and sensitivity, and ease of sample collection and analysis. ..
  21. Novel Multiple-Component X-C/C-C Formation Reactions
    Guigen Li; Fiscal Year: 2003
    ..In addition, 6 graduate students have been or are still being trained by PI's synthesis projects. This R15 grant application is very important for the PI to continue his teaching and research activities at Texas Tech. ..
  22. Modeling Human Exposure-Dose Relationships:1,3-Butadiene
    Thomas Smith; Fiscal Year: 2005
    ..Similarly differences in the formation and detoxification rates will be tested for associations with subject characteristics, such as genotypes and dietary antioxidants. Findings will be important for US risk assessments...
  23. EFFECTS OF XENOBIOTICS ON RENAL MEMBRANE TRANSPORT
    William Berndt; Fiscal Year: 1991
    ..The nephrotoxicants to be studied are mercuric chloride, potassium dichromate, citrinin and hexachloro-1,3-butadiene. The membrane vesicles will be prepared from rat renal tissue by Percoll gradient centrifugation...
  24. TOXICITY AND CARCINOGENCITY STUDIES
    HARVEY RAGAN; Fiscal Year: 1991
    ..The results of the 13 wk studies will be used by NIP to establish doses to be used in chronic studies. The results of the 2-year study will be used by NTP to determine onset of carcinogenesis with exposure to 1,3-butadiene...
  25. BLOOD INTERACTIONS OF TRIBLOCK COPOLYMERS
    Joseph Andrade; Fiscal Year: 1980
    ....
  26. SUSCEPTIBILITY TO GENETIC DAMAGE FROM BUTADIENE
    Karl Kelsey; Fiscal Year: 1993
    ....
  27. NEW REAGENTS AND MATERIALS FROM HIGHLY REACTIVE METALS
    LISHAN ZHU; Fiscal Year: 1993
    ....
  28. POLYEN PHOTOPHYSICS--RESONANCE RAMAN INTENSITY STUDIES
    ANNE KELLEY; Fiscal Year: 1990
    ....
  29. CELLULAR & MOLECULAR TOXICOLOGY OF BUTADIENE
    Perpetua Muganda; Fiscal Year: 2003
    ..The overall outcome of this collaborative program will be increased scientific development, productivity, and ability of SUBR investigators to successfully compete for NIH R01 funding in environmental health sciences. ..
  30. DNA and Hemoglobin Adducts of Butenediol Metabolites
    MARK POWLEY; Fiscal Year: 2004
    ..This will improve our understanding of BD metabolism as a whole and ultimately increase our ability to accurately assess the risk of BD to humans. ..
  31. LC-MS/MS FOR HIGHLY SENSITIVE BIOMARKER DETECTION
    James Swenberg; Fiscal Year: 2005
    ..abstract_text> ..
  32. ADDUCTS AS QUANTITATIVE MARKERS OF BUTADIENE MUTAGENESIS
    James Swenberg; Fiscal Year: 2009
    ..Ultimately these data will improve our understanding of critical mechanisms of toxicity and ability to accurately assess the risk of BD to humans. ..
  33. Smokers and PREPs: Measurement of Inhaled and Exhaled Tobacco Smoke Particulate
    Sydney Gordon; Fiscal Year: 2009
    ....
  34. Azinomycins - Total Synthesis and Mechanism of Action
    Robert Coleman; Fiscal Year: 2007
    ..abstract_text> ..
  35. Asymmetric Synthesis of Cytotoxic Natural Products
    Robert Coleman; Fiscal Year: 2005
    ..abstract_text> ..
  36. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  37. Signal Transduction Mechanisms in Neuroendocrine Neurons
    Arshad Khan; Fiscal Year: 2006
    ..This training will further my career goal of studying cellular signaling using an in vivo approach. ..
  38. SYNTHESIS OF NOVEL BIOLOGICALLY ACTIVE NATURAL PRODUCTS
    ROBERT BOECKMAN; Fiscal Year: 2002
    ..The hypothesis that an internal chelate of suitably disposed oxygen functions permits the modification of the ring conformation from half-chair to half-boat will be tested. ..
  39. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  40. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  41. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2002
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
  42. The Role of N1-Inosine Adducts in Butadiene Mutagenesis
    Gunnar Boysen; Fiscal Year: 2005
    ..Addressing this hypothesis is essential for determining the sources of BD mutations and will ultimately increase our ability to accurately assess the risk of BD to humans. ..
  43. Dedifferentiation Following Renal Cell Injury
    Shougang Zhuang; Fiscal Year: 2009
    ..These studies will increase our knowledge of the mechanisms of RPTC dedifferentiation after injury and may contribute to the development of novel treatment for patients with ARF. ..
  44. Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)
    Christian Schmidt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. Lovelace Respiratory Symposium 2003
    Rogene Henderson; Fiscal Year: 2003
    ..Future topics will be developed with the same sensitivity to meeting the information needs of our audience. Continuing medical education credits are available through the University of New Mexico School of Medicine. ..
  46. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
  47. Postdoctoral Training Program in Neural Regeneration
    Oswald Steward; Fiscal Year: 2005
    ....
  48. 9th International Conference on Environmental Mutagens: Student Travel Expenses
    Jonathan Ward; Fiscal Year: 2005
    ..Awards will be made without regard to gender, race, ethnicity, nationality, or disability. ..
  49. MECHANISMS OF INJURY POTENTIATION BY GROWTH FACTORS
    DOUGLAS LOBNER; Fiscal Year: 2004
    ..It is believed that these studies will aid in determining under what conditions growth factor induced potentiation of cell death may be of concern regarding their therapeutic use, and how those concerns may be addressed. ..
  50. C/EBPB And Mitotic Clonal Expansion During Adipogenesis
    Qi Qun Tang; Fiscal Year: 2004
    ..identify the kinase(s) that catalyzes this/these phosphorylation/s and to determine how the kinase(s) is regulated. -determine the role of C/EBP-beta in mitotic clonal expansion and how phosphorylation of C/EBP-beta affects this role...
  51. Failure of FasL Mediated Pathways in Tumor Angiogenesis
    Vijay Shah; Fiscal Year: 2006
    ..These insights may lead to novel and effective therapeutic strategies that target this pathway to prevent angiogenesis, and thereby prevent colorectal tumor development growth and spread. ..
  52. Linking folate deficiency to changes in gene expression
    KAREN KATULA; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  53. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  54. Molecular Mechanisms of Portal Hypertension
    Vijay Shah; Fiscal Year: 2007
    ..abstract_text> ..
  55. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  56. UIC and Chicago State MS/PHD Bridge to Future
    Nurtan Esmen; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. Summer Training Program in Neuroscience
    Oswald Steward; Fiscal Year: 2006
    ..Where appropriate, trainees will be encouraged to present their results at national meetings, and support will be provided for students to attend such meetings. [unreadable] [unreadable]..
  58. Diepoxide Cross-Linking of DNA
    JULIE MILLARD; Fiscal Year: 2003
    ..Denaturing PAGE will also be used to characterize DNA reaction products of epichiorohydrin to elucidate the impact of a three-carbon chain length in cross-linking. ..