brominated hydrocarbons

Summary

Top Publications

  1. ncbi Alternate and new brominated flame retardants detected in U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 42:6910-6. 2008
  2. ncbi Occurrence and bioavailability of polybrominated diphenyl ethers and hexabromocyclododecane in sediment and fish from the Cinca River, a tributary of the Ebro River (Spain)
    Ethel Eljarrat
    Department of Environmental Chemistry, IIQAB, CSIC, Jordi Girona 18 26, 08034 Barcelona, Spain
    Environ Sci Technol 38:2603-8. 2004
  3. pmc Brominated flame retardants: cause for concern?
    Linda S Birnbaum
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 112:9-17. 2004
  4. ncbi Brominated and chlorinated dioxins, PCBs and brominated flame retardants in Scottish shellfish: methodology, occurrence and human dietary exposure
    Alwyn Fernandes
    Central Science Laboratory Environment, Food and Health, Sand Hutton, York, UK
    Mol Nutr Food Res 52:238-49. 2008
  5. ncbi Hexabromocyclododecanes (HBCDs) in the environment and humans: a review
    Adrian Covaci
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Environ Sci Technol 40:3679-88. 2006
  6. ncbi Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome p450
    Bart N Zegers
    Royal Netherlands Institute for Sea Research NIOZ, 1790 AB Den Burg, Texel
    Environ Sci Technol 39:2095-100. 2005
  7. ncbi Biomagnification of polybrominated diphenyl ether and hexabromocyclododecane flame retardants in the polar bear food chain in Svalbard, Norway
    Eugen Gravningen Sørmo
    Norwegian University of Science and Technology, Department of Biology, NO 7491 Trondheim, Norway
    Environ Toxicol Chem 25:2502-11. 2006
  8. ncbi Determination of flame-retardant hexabromocyclododecane diastereomers in textiles
    Natsuko Kajiwara
    Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Chemosphere 74:1485-9. 2009
  9. pmc In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds
    I A Meerts
    Toxicology Group, Wageningen University and Research Center, Wageningen, The Netherlands
    Environ Health Perspect 109:399-407. 2001
  10. ncbi Two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats
    Makoto Ema
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Reprod Toxicol 25:335-51. 2008

Detail Information

Publications190 found, 100 shown here

  1. ncbi Alternate and new brominated flame retardants detected in U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 42:6910-6. 2008
    ..This study highlights the fact that numerous types of brominated flame retardants are present in indoor environments, raising questions about exposure to mixtures of these contaminants...
  2. ncbi Occurrence and bioavailability of polybrominated diphenyl ethers and hexabromocyclododecane in sediment and fish from the Cinca River, a tributary of the Ebro River (Spain)
    Ethel Eljarrat
    Department of Environmental Chemistry, IIQAB, CSIC, Jordi Girona 18 26, 08034 Barcelona, Spain
    Environ Sci Technol 38:2603-8. 2004
    ..Moreover, PBDE and HBCD concentrations are correlated with fish length indicating the bioaccumulation of these contaminants...
  3. pmc Brominated flame retardants: cause for concern?
    Linda S Birnbaum
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 112:9-17. 2004
    ..Overall, the toxicology database is very limited; the current literature is incomplete and often conflicting. Available data, however, raise concern over the use of certain classes of brominated flame retardants...
  4. ncbi Brominated and chlorinated dioxins, PCBs and brominated flame retardants in Scottish shellfish: methodology, occurrence and human dietary exposure
    Alwyn Fernandes
    Central Science Laboratory Environment, Food and Health, Sand Hutton, York, UK
    Mol Nutr Food Res 52:238-49. 2008
    ..The corresponding intakes for sumPBDEs and sumHBCDs were 5.6-6.1 and 5.9-7.9 ng/kg bodyweight/day respectively...
  5. ncbi Hexabromocyclododecanes (HBCDs) in the environment and humans: a review
    Adrian Covaci
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Environ Sci Technol 40:3679-88. 2006
    ..Whenever possible, HBCDs should be analyzed as individual stereoisomers in order to address their fate and effects...
  6. ncbi Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome p450
    Bart N Zegers
    Royal Netherlands Institute for Sea Research NIOZ, 1790 AB Den Burg, Texel
    Environ Sci Technol 39:2095-100. 2005
    ....
  7. ncbi Biomagnification of polybrominated diphenyl ether and hexabromocyclododecane flame retardants in the polar bear food chain in Svalbard, Norway
    Eugen Gravningen Sørmo
    Norwegian University of Science and Technology, Department of Biology, NO 7491 Trondheim, Norway
    Environ Toxicol Chem 25:2502-11. 2006
    ..This study demonstrates that PBDEs and HBCD have reached measurable concentrations even in the lower trophic levels (invertebrates and fish) in the Arctic and biomagnifies in the polar bear food chain...
  8. ncbi Determination of flame-retardant hexabromocyclododecane diastereomers in textiles
    Natsuko Kajiwara
    Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Chemosphere 74:1485-9. 2009
    ....
  9. pmc In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds
    I A Meerts
    Toxicology Group, Wageningen University and Research Center, Wageningen, The Netherlands
    Environ Health Perspect 109:399-407. 2001
    ..These data also suggest that in vivo metabolism of PBDEs may produce more potent pseudoestrogens...
  10. ncbi Two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats
    Makoto Ema
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Reprod Toxicol 25:335-51. 2008
    ..The data indicate that the NOAEL of HBCD in this study was 150 ppm (10.2mg/kg bw/day). The estimated human intake of HBCD is well below the NOAEL in the present study...
  11. ncbi Consumption of fish from a contaminated lake strongly affects the concentrations of polybrominated diphenyl ethers and hexabromocyclododecane in serum
    Cathrine Thomsen
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 52:228-37. 2008
    ..The median serum HBCD concentration was 4.1 and 2.6 ng/g lipids for men and women, respectively, and was also found to be associated with consumption of fish from Lake Mjøsa...
  12. ncbi Brominated flame retardants in US food
    Arnold Schecter
    University of Texas School of Public Health at Southwestern Medical Center, Dallas, TX, USA
    Mol Nutr Food Res 52:266-72. 2008
    ..The levels are lower than PBDEs, 0.16-1.2 ng/g, similar to European levels, unlike PBDEs where US levels are much higher than European levels...
  13. ncbi Time trend of hexabromocyclododecane in the breast milk of Japanese women
    Kensaku Kakimoto
    Osaka Prefectural Institute of Public Health, 1 3 69, Nakamichi, Higashinari ku, Osaka 537 0025, Japan
    Chemosphere 71:1110-4. 2008
    ..Time trend of summation operatorHBCD appeared to be related to that of the industrial HBCD consumption level in Japan...
  14. ncbi Levels of the flame retardants hexabromocyclododecane and tetrabromobisphenol A in the blubber of harbor porpoises (Phocoena phocoena) stranded or bycaught in the U.K., with evidence for an increase in HBCD concentrations in recent years
    Robin J Law
    The Centre for Environment, Fisheries and Aquaculture Science, CEFAS Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, UK
    Environ Sci Technol 40:2177-83. 2006
    ..This may be a result of changing patterns of use of HBCD following limitations on the production and use of two PBDE formulations within the EU and will feed ongoing risk assessment activities...
  15. ncbi Occupational exposure to hexabromocyclododecane at an industrial plant
    Cathrine Thomsen
    Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    Environ Sci Technol 41:5210-6. 2007
    ..The elevated exposure levels reported in this study compared to urban air and serum levels in general populations suggest that further and more detailed exposure assessment studies should be initiated in industries where HBCD is applied...
  16. ncbi Tetrabromobisphenol A (TBBPA) and hexabromocyclododecanes (HBCDs) in tissues of humans, dolphins, and sharks from the United States
    Boris Johnson-Restrepo
    Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, Albany, NY 12201 0509, USA
    Chemosphere 70:1935-44. 2008
    ..The present report is the first to determine levels of TBBPA and HBCDs in humans, bottlenose dolphins, and sharks from the United States...
  17. ncbi Exposure assessment of fetus and newborn to brominated flame retardants in France: preliminary data
    Jean Philippe Antignac
    Laboratoire d Etude des Résidus et Contaminants dans Aliments, USC INRA 2013, Ecole Nationale Veterinaire de Nantes, Nantes, France
    Mol Nutr Food Res 52:258-65. 2008
    ..Additional data collection and metabolism investigations are now on-going. A more complete statistical analysis related to this BFR exposition study will be provided in a next future...
  18. ncbi Polybrominated diphenyl ether flame retardants in the North American environment
    Robert C Hale
    Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, 1208 Greate Road, Gloucester Point, VA 23062, USA
    Environ Int 29:771-9. 2003
    ..This lack of redistribution is likely due to its extremely low volatility and water solubility. Penta-BDE and Deca-BDE products are used in different applications and this may also be a factor controlling their environmental release...
  19. ncbi Temporal trend studies on tetra- and pentabrominated diphenyl ethers and hexabromocyclododecane in guillemot egg from the Baltic Sea
    Ulla Sellström
    Laboratory for Analytical Environmental Chemistry, Institute of Applied Environmental Research, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Sci Technol 37:5496-501. 2003
    ..During the recent 10-yr period no significant change has occurred, and the annual mean concentrations are more or less stable at a higher level as compared to the beginning of the study period...
  20. ncbi Factors influencing enantiomeric fractions of hexabromocyclododecane measured using liquid chromatography/tandem mass spectrometry
    Chris H Marvin
    Environment Canada, 867 Lakeshore Road, Burlington, Ontario L7R 4A6 Canada
    Rapid Commun Mass Spectrom 21:1925-30. 2007
    ....
  21. ncbi Levels of polybrominated diphenyl ether (PBDE) flame retardants in animals representing different trophic levels of the North Sea food Web
    Jan P Boon
    Royal Netherlands Institute for Sea Research NIOZ, P O Box 59, 1790 AB Den Burg, Texel, The Netherlands
    Environ Sci Technol 36:4025-32. 2002
    ..This has serious consequences for the route of elimination of POPs, since their elimination from the blood into the ambient seawater via the gill-membrane is no longer possible...
  22. ncbi The environmental occurrence of hexabromocyclododecane in Sweden
    Mikael Remberger
    IVL Swedish Environmental Research Institute, SE 100 31 Stockholm, Sweden
    Chemosphere 54:9-21. 2004
    ..The presence of HBCD in remote background air implies that HBCD has potential for long-range atmospheric transport. There are also some indications that diffuse emissions of HBCD occur in the urban environment...
  23. ncbi A significant downturn in levels of hexabromocyclododecane in the blubber of harbor porpoises (Phocoena phocoena) stranded or bycaught in the UK: an update to 2006
    Robin J Law
    Centre for Environment, Fisheries and Aquaculture Science, CEFAS Lowestoft Laboratory, Pakefield Road, Lowestoft NR33 OHT, UK
    Environ Sci Technol 42:9104-9. 2008
    ....
  24. ncbi Effect of inhalation exposure to 2-bromopropane on the nervous system in rats
    X Yu
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    Toxicology 135:87-93. 1999
    ..In 100-ppm exposed rats (n = 9), no significant changes were noted in body weight and the peripheral nerve. In conclusions, long-term exposure to 1000 ppm of 2-BP may result in peripheral neuropathy in rats...
  25. ncbi Polybrominated diphenyl ether (PBDE) flame retardants
    F Rahman
    Environmental Processes and Water Technology Group, T.H. Huxley School of the Environment, Earth Sciences and Engineering, Imperial College of Science, Technology and Medicine, London, UK
    Sci Total Environ 275:1-17. 2001
    ..The manufacture of reactive and additive flame retardants is briefly discussed and their fate and behaviour in the environment is assessed. PBDE toxicology is reviewed and methods of analysis are evaluated...
  26. ncbi Causes of variability in concentrations and diastereomer patterns of hexabromocyclododecanes in indoor dust
    Stuart Harrad
    Division of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    Environ Int 35:573-9. 2009
    ..Significant negative correlation was observed in one room between concentrations of SigmaHBCDs and dust loading (g dust m(-2) floor), implying "dilution" occurs at higher dust loadings...
  27. ncbi Hexabromocyclododecanes and tetrabromobisphenol-A in indoor air and dust in Birmingham, U.K: implications for human exposure
    Mohamed Abou Elwafa Abdallah
    Division of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Environ Sci Technol 42:6855-61. 2008
    ..Inhalation appears a minor exposure pathway to both HBCDs and TBBP-A. On average, dust is 33% alpha-, 11% beta-, and 56% gamma-HBCD, while air is 22% alpha-, 11% beta-, and 65% gamma-HBCD...
  28. ncbi Temporal trends, congener patterns, and sources of octa-, nona-, and decabromodiphenyl ethers (PBDE) and hexabromocyclododecanes (HBCD) in Swiss lake sediments
    Martin Kohler
    Empa, Swiss Federal Laboratories for Materials Testing and Research, Uberlandstrasse 129, 8600 Dubendorf, Switzerland
    Environ Sci Technol 42:6378-84. 2008
    ....
  29. ncbi Regio- and stereoselective isomerization of hexabromocyclododecanes (HBCDs): kinetics and mechanism of gamma- to alpha-HBCD isomerization
    Norbert V Heeb
    Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Analytical Chemistry, Uberlandstrasse 129, CH 8600 Dubendorf, Switzerland
    Chemosphere 73:1201-10. 2008
    ..Thus, this structural motive, common to all alpha-, beta-, and gamma-HBCDs, is more rigid and less reactive than the flexible part, containing the reacting dibromides in like-configurations...
  30. ncbi Determination of HBCD, PBDEs and MeO-BDEs in California sea lions (Zalophus californianus) stranded between 1993 and 2003
    H M Stapleton
    Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Mar Pollut Bull 52:522-31. 2006
    ..In addition, HBCD concentrations appear to be increasing in California sea lion populations, whereas PBDE concentrations, between 1993 and 2003, were highly variable...
  31. ncbi Comparative evaluation of liquid chromatography-mass spectrometry versus gas chromatography-mass spectrometry for the determination of hexabromocyclododecanes and their degradation products in indoor dust
    Mohamed Abou Elwafa Abdallah
    Division of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    J Chromatogr A 1190:333-41. 2008
    ..This finding suggests that the elimination of HBr is the major degradation pathway for HBCDs in dust...
  32. ncbi Biotransformation enzymes and thyroid axis disruption in juvenile rainbow trout (Oncorhynchus mykiss) exposed to hexabromocyclododecane diastereoisomers
    Vince P Palace
    Department of Fisheries and Ocean, Freshwater Institute, Winnipeg, Manitoba, R3T 2N6, Canada
    Environ Sci Technol 42:1967-72. 2008
    ..Results from these experiments indicate that all isomers have the potential to disrupt thyroid homeostasis...
  33. ncbi Hexabromocyclododecane in human breast milk: levels and enantiomeric patterns
    Ethel Eljarrat
    Department of Environmental Chemistry, IDAEA, Consejo Superior de Investigaciones Cientificas, Jordi Girona 18 26, 08034 Barcelona, Spain
    Environ Sci Technol 43:1940-6. 2009
    ..Finally, and based on the calculated HBCD concentrations in human breast milk from Spain, the daily ingestion rate of HBCD was estimated. The nursing infant dietary intake for HBCD was set at 175 ng (kg of body weight)(-1) day(-1)...
  34. ncbi Levels and trends of brominated flame retardants in the European environment
    Robin J Law
    The Centre for Environment, Fisheries and Aquaculture Science, CEFAS Burnham Laboratory, Burnham on Crouch, Remembrance Avenue, Essex CM0 8HA, UK
    Chemosphere 64:187-208. 2006
    ....
  35. ncbi Brominated flame retardants in Alburnus alburnus from Cinca River Basin (Spain)
    Ethel Eljarrat
    Department of Environmental Chemistry, IIQAB, CSIC, Jordi Girona 18 26, 08034 Barcelona, Spain
    Environ Pollut 133:501-8. 2005
    ..Moreover, PBDE and HBCD concentrations are correlated with fish length and weight indicating the bioaccumulation of these contaminants...
  36. ncbi Occurrence of polychlorinated biphenyls and polybrominated diphenyl ethers in belgian human adipose tissue samples
    C Naert
    Laboratory of Food Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, Ghent 9000, Belgium
    Arch Environ Contam Toxicol 50:290-6. 2006
    ..023, p = 0.873), whereas PCBs showed higher correlation coefficients with age (Pearson correlation 0.613, p < 0.0005). There was no relationship between PBDE and PCB levels (Pearson correlation -0.010, p = 0.943)...
  37. ncbi Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density
    Jana Weiss
    Department of Environmental Chemistry, Stockholm University, SE 10691 Stockholm, Sweden
    Environ Sci Technol 40:6282-9. 2006
    ..HBCDD diastereomeric and enantiomeric patterns were determined by liquid chromatography with mass spectrometric detection. The dominating stereoisomer was (-)alpha-HBCDD, but 1-3% of gamma-HBCDD was also detected in the serum samples...
  38. ncbi A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats
    Leo T M Van der Ven
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 94:281-92. 2006
    ..Overall, female rats appeared to be more sensitive to HBCD than male rats, and an overall BMDL is proposed at 1.6 mkd, based on a 10% increase of the thyroid weight, which was the most sensitive parameter in the sequence of events...
  39. ncbi Occupational health survey on workers exposed to 2-bromopropane at low concentrations
    G Ichihara
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    Am J Ind Med 35:523-31. 1999
    ..We aimed to clarify the dose-effect relationship of 2-bromopropane in workers...
  40. ncbi Dietary exposure to brominated flame retardants correlates with male blood levels in a selected group of Norwegians with a wide range of seafood consumption
    Helle K Knutsen
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 52:217-27. 2008
    ..Further, significant but weak correlations were found between dietary exposure and serum levels for Sum PBDEs, BDE-47, and BDE-28 in males. This indicates that other sources in addition to diet need to be addressed...
  41. ncbi Distribution and fate of HBCD and TBBPA brominated flame retardants in North Sea estuaries and aquatic food webs
    Steven Morris
    Centre for Environment, Fisheries and Aquaculture Science, Weymouth Laboratory, Weymouth, Dorset, United Kingdom DT4 8UB
    Environ Sci Technol 38:5497-504. 2004
    ..This study shows evidence of HBCD bioaccumulation at the trophic level and biomagnification in the ascending aquatic food chain, and these findings justify risk assessment studies at the ecosystem level...
  42. ncbi Accumulation of organochlorines and brominated flame retardants in estuarine and marine food chains: field measurements and model calculations
    Karin Veltman
    Department of Environmental Studies, Institute for Wetland and Water Research, Radboud University Nijmegen, P O Box 9010, 6500 GL Nijmegen, The Netherlands
    Mar Pollut Bull 50:1085-102. 2005
    ..BDE47 is the predominant congener in lower trophic levels. For marine birds and mammals accumulation ratios of BDE99 and 100 are similar to or higher than ratios of persistent PCBs...
  43. ncbi Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures
    Mark J LaA Guardia
    Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, Virginia 23062, USA
    Environ Sci Technol 40:6247-54. 2006
    ..02%. Five other congeners (four <0.02% by weight) were tentatively identified based on their molecular ion and ECNI fragmentation in the absence of corresponding analytical standards...
  44. ncbi Exposure to 1-bromopropane causes ovarian dysfunction in rats
    Tetsuya Yamada
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Toxicol Sci 71:96-103. 2003
    ..Our results indicate that 1-bromopropane can induce a dose-dependent ovarian dysfunction in nonpregnant female rats associated with disruption in follicular growth process...
  45. ncbi Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days
    Hailan Wang
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Toxicol Sci 67:114-20. 2002
    ..Glutathione depletion or modification to functional proteins containing a sulfhydryl base as a critical site might be the underlying mechanism of 1-bromopropane neurotoxicity...
  46. ncbi Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane
    Hailan Wang
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurotoxicology 24:199-206. 2003
    ..The biochemical changes in the cerebrum indicate that long-term exposure to 1-bromopropane has effects on the CNS...
  47. ncbi Encephalomyeloradiculoneuropathy following exposure to an industrial solvent
    G Sclar
    Department of Neurosciences, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
    Clin Neurol Neurosurg 101:199-202. 1999
    ..Similar findings have been reported following 1-bromopropane exposure in rats. I hypothesize that this patient's symptoms may have been due to 1-bromopropane-induced neurotoxicity...
  48. ncbi A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane
    Gaku Ichihara
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Ind Med 45:63-75. 2004
    ..The aim of this study was to evaluate the health effects of exposure mainly to 1-bromopropane, which is an alternative to ozone-depleting solvents, and to establish biomarkers for assessing 1-bromopropane exposure...
  49. ncbi Toxicity and physiological effects of brominated flame retardant PBDE-47 on two life stages of grass shrimp, Palaemonetes pugio
    Peter B Key
    National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Ft Johnson Road, Charleston, SC 29412, United States
    Sci Total Environ 399:28-32. 2008
    ..Effects associated with PBDE-47 aqueous exposures were observed at levels well above those reported in the environment...
  50. ncbi Disposition of BDE 47 in developing mice
    Daniele F Staskal
    UNC Curriculum in Toxicology, USA
    Toxicol Sci 90:309-16. 2006
    ..These differences lead to higher concentrations of BDE 47 at target tissues during critical windows of development...
  51. ncbi Analysis of brominated flame retardants in styrenic polymers. Comparison of the extraction efficiency of ultrasonication, microwave-assisted extraction and pressurised liquid extraction
    Francisco Vilaplana
    Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, KTH Royal Institute of Technology, Teknikringen 56 58, Stockholm, Sweden
    J Chromatogr A 1196:139-46. 2008
    ....
  52. ncbi New multiresidue analytical method dedicated to trace level measurement of brominated flame retardants in human biological matrices
    Ronan Cariou
    Laboratoire d Etude des Résidus et Contaminants dans les Aliments LABERCA, Ecole Nationale Veterinaire de Nantes, France
    J Chromatogr A 1100:144-52. 2005
    ..This protocol was fully validated and was proved to be suitable for identification of brominated flame retardant residues at ultra-trace level, as attested by preliminary results on real samples...
  53. ncbi Brominated flame retardants in the environment of Asia-Pacific: an overview of spatial and temporal trends
    Shinsuke Tanabe
    Center for Marine Environmental Studies, Ehime University, Bunkyo cho 2 5, Matsuyama, 790 8577, Japan
    J Environ Monit 10:188-97. 2008
    ..In view of the rising environmental levels and the high consumption volume of BFRs in Asia, further efforts should be made to monitor environmental contamination by these chemicals in order to identify sources and reduce emissions...
  54. ncbi Temporal trends of polybrominated diphenyl ethers and hexabromocyclododecane in milk from Stockholm mothers, 1980-2004
    Britta Fängström
    Department of Environmental Chemistry, Stockholm University, Stockholm, Sweden
    Mol Nutr Food Res 52:187-93. 2008
    ..DecaBDE (BDE-209) is not a suitable biomarker for time trend studies according to the present results, showing no changes over time. This is likely due to its short apparent half-life in humans and poor transfer from blood to milk...
  55. ncbi Concentrations and specific loads of brominated flame retardants in sewage sludge
    Thomas Kupper
    Swiss College of Agriculture, 3052 Zollikofen, Switzerland
    Chemosphere 71:1173-80. 2008
    ..Loads from different types of monitoring sites showed that brominated flame retardants ending up in sewage sludge originate mainly from surface runoff, industrial and domestic wastewater...
  56. pmc Brominated flame retardants in North-East Atlantic marine ecosystems
    Bjørn Munro Jenssen
    Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway
    Environ Health Perspect 115:35-41. 2007
    ..Concentrations of brominated flame retardants (BFRs) are reported to increase in marine ecosystems...
  57. ncbi The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators
    Erik K Pacyniak
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 97:94-102. 2007
    ..In summary, our study provides the first evidence that PBDEs are activators for xenobiotic nuclear receptor...
  58. ncbi Spatial distribution and vertical profile of polybrominated diphenyl ethers and hexabromocyclododecanes in sediment core from Tokyo Bay, Japan
    Nguyen Hung Minh
    Center for Marine Environmental Studies, Ehime University, Matsuyama 790 8577, Japan
    Environ Pollut 148:409-17. 2007
    ..HBCDs first appeared in the mid-1970s and increased until today. The annual surficial flux of HBCDs (0.62-2.4 ng/cm2/yr) is equal to summation operatorPBDEs (0.95-2.6 ng/cm2/yr) but lower than that of BDE-209 (17-58 ng/cm2/yr)...
  59. ncbi Plasma PBDE and thyroxine levels in rats exposed to Bromkal or BDE-47
    Per Ola Darnerud
    National Food Administration, P O Box 622, SE 751 26 Uppsala, Sweden
    Chemosphere 67:S386-92. 2007
    ..Lastly, it should be noted that humans are already exposed to a mixture of chemicals in daily life, a fact that complicates this kind of comparison...
  60. ncbi Spatial distribution and accumulation of brominated flame retardants, polychlorinated biphenyls and organochlorine pesticides in blue mussels (Mytilus edulis) from coastal waters of Korea
    Karri Ramu
    Center for Marine Environmental Studies CMES, Ehime University, Matsuyama 790 8577, Japan
    Environ Pollut 148:562-9. 2007
    ..For all the compounds, higher concentrations were found in mussels from southeastern coast of Korea. The present study shows the importance of mussels as bioindicators for monitoring contaminants in coastal waters...
  61. ncbi Physicochemical properties of selected polybrominated diphenyl ethers and extension of the UNIFAC model to brominated aromatic compounds
    Hidetoshi Kuramochi
    Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Chemosphere 67:1858-65. 2007
    ..The ability of the determined parameters to represent both properties of brominated aromatics was evaluated...
  62. ncbi The expression of CYP1A, vitellogenin and zona radiata proteins in Atlantic salmon (Salmo salar) after oral dosing with two commercial PBDE flame retardant mixtures: absence of short-term responses
    J P Boon
    Royal Netherlands Institute for Sea Research NIOZ, Department of Marine Biogeochemistry and Toxicology, Texel
    Mar Environ Res 54:719-24. 2002
    ....
  63. ncbi Congener distribution of polybrominated diphenyl ethers in feral carp (Cyprinus carpio) from the Llobregat River, Spain
    Ana Labandeira
    Department of Environmental Chemistry, IIQAB, CSIC, Jordi Girona 18 26, 08034 Barcelona, Spain
    Environ Pollut 146:188-95. 2007
    ..Similar results were observed for BDE-153, BDE-183 and BDE-209. The main reason for their concentration decrease or absence in biota may be due to low bioavailability potential or due to biotransformation processes...
  64. ncbi Spatial and temporal changes of chlorinated pesticides, PCBs, dioxins (PCDDs/PCDFs) and brominated flame retardants in human breast milk from Northern Russia
    A Polder
    The Norwegian School of Veterinary Science, Oslo, Norway
    Sci Total Environ 391:41-54. 2008
    ..The exposure of infants by PCDDs/PCDFs and dioxin-like PCBs is still exceeding the daily tolerable intake (TDI) in North West Russia. However, the concentrations of PCDDs/PCDFs and dioxin-like PCBs seem to decline very rapidly...
  65. ncbi Neurotoxicity of the pentabrominated diphenyl ether mixture, DE-71, and hexabromocyclododecane (HBCD) in rat cerebellar granule cells in vitro
    Trine Reistad
    Division for Protection, Norwegian Defence Research Establishment, Kjeller, Norway
    Arch Toxicol 80:785-96. 2006
    ..Our results indicate that the lower brominated PBDEs have a higher potency of bioaccumulation than HBCD, and that both compounds have a neurotoxic potential in vitro...
  66. ncbi Screening of halogenated aromatic compounds in some raw material lots for an aluminium recycling plant
    Seija Sinkkonen
    Department of Chemistry, University of Jyvaskyla, PO Box 35, FIN 40351 Jyvaskyla, Finland
    Environ Int 30:363-6. 2004
    ..The concentrations of PCBs, PCNs (polychlorinated naphthalenes) and nona- to undecachlorinated terphenyls in some of these scrap samples were remarkably high...
  67. ncbi Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural development
    Igor Branchi
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, Italy
    Neurotoxicology 23:375-84. 2002
    ..The possibility of exposure of neonates to PBDEs warrants further studies to characterise their developmental neurotoxicity...
  68. ncbi [Flame retardants--use and hazards for human]
    Katarzyna Góralczyk
    Zakład Toksykologii Srodowiskowej Państwowy Zakład Higieny 00 791 Warszawa, ul Chocimska 24
    Rocz Panstw Zakl Hig 53:293-305. 2002
    ..Currently, the estimated daily intake of PBDEs by adult humans is equal 51 ng x day-1 while by breast-fed infants equals 110 ng x day-1...
  69. ncbi Impact of fermented brown rice with Aspergillus oryzae (FEBRA) intake and concentrations of polybrominated diphenylethers (PBDEs) in blood of humans from Japan
    Takumi Takasuga
    Shimadzu Techno Research Inc, 1, Nishinokyo Shimoaicho, Nakagyo ku, Kyoto 604 8436, Japan
    Chemosphere 57:795-811. 2004
    ....
  70. ncbi Polybrominated diphenyl ethers: human tissue levels and toxicology
    Udai Gill
    Environmental Research Division, First Nations and Inuit Health Branch, Health Canada, Ottawa, Ontario, KIA 0L2, Canada
    Rev Environ Contam Toxicol 183:55-97. 2004
    ..However, no toxicokinetics data are available for humans, and the actual margin of safety may be much smaller if based on levels in critical target organs or tissues...
  71. ncbi Determination of brominated flame retardants, with emphasis on polybrominated diphenyl ethers (PBDEs) in environmental and human samples--a review
    Adrian Covaci
    Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610, Antwerpen Wilrijk, Belgium
    Environ Int 29:735-56. 2003
    ..For each topic, an overview is given of the current status of the field and recommendations for an appropriate analytical approach are presented...
  72. ncbi Solar photodecomposition of decabromodiphenyl ether: products and quantum yield
    Juan Bezares-Cruz
    School of Civil Engineering, Purdue University, West Lafayette, Indiana 47907 1284, USA
    Environ Sci Technol 38:4149-56. 2004
    ....
  73. ncbi Levels and trends of polybrominated diphenylethers and other brominated flame retardants in wildlife
    Robin J Law
    Centre for Environment, Fisheries and Aquaculture Science, CEFAS Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, UK
    Environ Int 29:757-70. 2003
    ....
  74. ncbi BFR-governmental testing programme
    Sabine Kemmlein
    Federal Institute for Materials Research and Testing BAM, IV 22, Unter den Eichen 44 46, D 12200 Berlin, Germany
    Environ Int 29:781-92. 2003
    ..These studies are summarised below...
  75. ncbi Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase
    Erika N Segraves
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Med Chem 47:4060-5. 2004
    ..We report herein the effects of 21 simple and complex organobromine compounds against human platelet 12-LO, human reticulocyte 15-LO, and soybean 15-LO-1...
  76. ncbi Clarifications on PBDE flame retardants
    K Rothenbacher
    Environ Sci Technol 37:238A. 2003
  77. ncbi Occurrence of polychlorinated biphenyls and polybrominated diphenyl ethers in green mussels (Perna viridis) from Singapore, Southeast Asia
    Stéphane Bayen
    Department of Chemistry, Tropical Marine Science Institute, National University of Singapore, Singapore
    Environ Toxicol Chem 22:2432-7. 2003
    ..At some sampling sites, the congener composition of PBDEs in P. viridis tissues indicated recent exposure to a commercial pentabrominated flame retardant...
  78. ncbi Primary sources of selected POPs: regional and global scale emission inventories
    Knut Breivik
    Norwegian Institute for Air Research NILU, PO Box 100, N 2027, Kjeller, Norway
    Environ Pollut 128:3-16. 2004
    ....
  79. ncbi Temporal trends and spatial distributions of brominated flame retardants in archived fishes from the Great Lakes
    Ling Yan Zhu
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA
    Environ Sci Technol 38:2779-84. 2004
    ....
  80. ncbi Further studies on the latitudinal and temporal trends of persistent organic pollutants in Norwegian and U.K. background air
    Foday M Jaward
    Department of Environmental Science, Institute of Environmental and Natural Sciences, Lancaster University, Lancaster LA1 4YQ, UK
    Environ Sci Technol 38:2523-30. 2004
    ..No systematic differences in congeners or locations were noted, supporting the hypothesis that the underlying trends in European background air are still controlled by primary, rather than secondary, sources...
  81. ncbi Some polybrominated diphenyl ether (PBDE) flame retardants with wide environmental distribution inhibit TCDD-induced EROD activity in primary cultured carp (Cyprinus carpio) hepatocytes
    R V Kuiper
    Institute for Risk Assessment Sciences IRAS, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
    Aquat Toxicol 68:129-39. 2004
    ..The observation that detected PBDE levels are rising, stresses the need for caution when interpreting EROD data on environmental samples...
  82. ncbi Preventing fires, igniting questions
    Karen F Schmidt
    US News World Rep 136:70, 72. 2004
  83. ncbi Deca PBDE flame retardant gets around
    Kellyn S Betts
    Environ Sci Technol 38:50A-51A. 2004
  84. ncbi Differential effects of polybrominated diphenyl ethers and polychlorinated biphenyls on [3H]arachidonic acid release in rat cerebellar granule neurons
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, MD 74B, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 68:451-7. 2002
    ..These results indicate that PBDEs stimulated the release of [(3)H]AA by activating PLA(2), which is similar to the effect of other organohalogen mixtures...
  85. ncbi [Polybrominated diphenyl ether flame retardants in foodstuffs and human milk]
    Kazuhiko Akutsu
    Osaka Prefectural Institute of Public Health 1 3 69, Nakamichi, Higashinari ku, Osaka 537 0025, Japan
    Shokuhin Eiseigaku Zasshi 45:175-83. 2004
    ..In this review, published information on the toxicology of PBDEs, levels in foodstuffs and human milk, and analytical methods has been compiled...
  86. ncbi Polybrominated diphenyl ethers (PBDEs), polybrominated dibenzo-p-dioxins/dibenzofurans (PBDD/Fs) and monobromo-polychlorinated dibenzo-p-dioxins/dibenzofurans (MoBPXDD/Fs) in the atmosphere and bulk deposition in Kyoto, Japan
    Kenichi Hayakawa
    Environment Preservation Center, Kyoto University, Yoshidahonmachi, Sakyo ku, Kyoto 606 8501, Japan
    Chemosphere 57:343-56. 2004
    ..This relationship suggest that the PBDD/Fs in the atmosphere relate to PBDEs, which is an impurity of PBDE products, or formed by the manufacture or combustion of plastics containing PBDEs...
  87. ncbi Rapidly rising PBDE levels in North America
    Kellyn S Betts
    Environ Sci Technol 36:50A-52A. 2002
  88. ncbi Assessing the environmental fate of chemicals of emerging concern: a case study of the polybrominated diphenyl ethers
    Anna Palm
    Environmental Chemistry, Department of Chemistry, Umea University, Sweden
    Environ Pollut 117:195-213. 2002
    ..Specifically, 20 PBDE congeners are investigated using the suggested approach and research needs are identified...
  89. ncbi Flame retardants, surfactants and organotins in sediment and mysid shrimp of the Scheldt estuary (The Netherlands)
    Tim A Verslycke
    Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, J Plateaustraat 22, B 9000 Ghent, Belgium
    Environ Pollut 136:19-31. 2005
    ..This study is the first to report high levels of endocrine disruptors in estuarine mysids...
  90. ncbi PBDE information overlooked?
    Courtney M Price
    Environ Sci Technol 36:89A. 2002
  91. ncbi Brominated flame retardants: activities in a crustacean development test and in an ecdysteroid screening assay
    Leah Wollenberger
    Environment and Resources, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Environ Toxicol Chem 24:400-7. 2005
    ..The combination of in vitro assays and subchronic biotests with ecologically important crustacean species is a rapid and cost-effective tool when screening for sublethal effects of BFRs and other chemicals...
  92. ncbi A brominated flame retardant, 2,2',4,4',5-pentabromodiphenyl ether: uptake, retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development
    P Eriksson
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36, Uppsala, Sweden
    Toxicol Sci 67:98-103. 2002
    ..Thus, the behavioral disturbances observed in adult mice following neonatal exposure to 2,2',4,4',5-pentaBDE are induced during a defined critical period of neonatal brain development...
  93. ncbi A chemical and toxicological profile of Dutch North Sea surface sediments
    Hans J C Klamer
    National Institute for Coastal and Marine Management RIKZ, Ministry of Transport, Public Works and Water Management, P O Box 207, 9750 AE Haren, The Netherlands
    Chemosphere 58:1579-87. 2005
    ..Our results therefore indicate that probably more dioxin-like toxicity associated with harbour sludge is disposed off at sea than assumed...
  94. ncbi Exposure to flame retardants: nursing concern
    Maye Thompson
    Oreg Nurse 69:12. 2004
  95. ncbi Tissue disposition, excretion and metabolism of 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) in the male Sprague-Dawley rat
    H Hakk
    USDA, ARS, Biosciences Research Laboratory, PO Box 5674, Fargo, ND 58105 5647, USA
    Xenobiotica 32:369-82. 2002
    ..The tissue (14)C was not associated with lipids and was mainly the unmetabolized parent compound. 8. Total thyroxine (T4) plasma levels were elevated at 3 and 6 days, and returned to control levels by day 12...
  96. ncbi Concentrations and spatial variations of polybrominated diphenyl ethers and several organochlorine compounds in fishes from the northeastern United States
    Nathan G Dodder
    Environmental Science Research Center, School of Public and Environmental Affairs, and Department of Chemistry, Indiana University, 47405, USA
    Environ Sci Technol 36:146-51. 2002
    ..Fish to sediment concentration ratios indicated that the tetra- through hexa-substituted congeners have a similar bioavailability, while the deca-substituted congener does not seem to be bioavailable at all...
  97. ncbi Distribution of organobrominated and organochlorinated contaminants in Belgian human adipose tissue
    Adrian Covaci
    Toxicological Center, University of Antwerp, Wilrijk, 2610, Belgium
    Environ Res 88:210-8. 2002
    ..56, P<0.05). No age dependency was found for PBDEs (r=0.09), while PCBs and DDTs showed higher correlation coefficients with age (r=0.59 and 0.40, respectively, P<0.05)...
  98. ncbi The toxicology of the three commercial polybrominated diphenyl oxide (ether) flame retardants
    M L Hardy
    Albemarle Corporation, Baton Rouge, LA 70801, USA
    Chemosphere 46:757-77. 2002
    ..In aquatic species, neither DBDPO nor OBDPO were toxic to aquatic organisms or bioconcentrating. Components of the PeBDPO product bioconcentrated in fish but produced little evidence of adverse effects...
  99. ncbi Determination of volatile organic hydrocarbons in water samples by solid-phase dynamic extraction
    Maik A Jochmann
    Center for Applied Geoscience ZAG, Eberhard Karls Universitat Tubingen, Sigwartstr 10, 72076, Tubingen, Germany
    Anal Bioanal Chem 387:2163-74. 2007
    ..As target compounds, benzene as well as 11 chlorinated and brominated hydrocarbons (vinyl chloride, dichloromethane, cis-1,2-dichloroethylene, trans-1,2-dichloroethylene, carbon ..
  100. ncbi Bioactivation of halogenated hydrocarbons by rabbit pulmonary cells
    W K Nichols
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112
    Pharmacol Toxicol 71:335-9. 1992
    ..These chlorinated and brominated hydrocarbons were studied to evaluate their ability to induce selective pneumotoxicity by their bioactivation in three ..
  101. ncbi Low-reflection-coefficient liquid interfaces for system characterization
    T J Hall
    Department of Radiology, University of Kansas Medical Center, Kansas City, KS 66160 7234, USA
    Ultrasound Med Biol 27:1003-10. 2001
    The use of liquid brominated hydrocarbons to form a planar reflecting interface with water is described...

Research Grants18

  1. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  2. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  3. Asymmetric Reaction Technologies for the Synthesis of Chemotherapeutic Agents
    Scott Nelson; Fiscal Year: 2007
    ..Furthermore, efforts to develop catalytic asymmetric variants of these cycloadditions are intended to maximize the utility of these reactions in industrial medicinal and process chemical research. ..
  4. Ovary Intact Murine Model for Menopause
    Patricia Hoyer; Fiscal Year: 2007
    ..Characterization of the VCD-treated mouse will, therefore, make a profound contribution to the study of menopause-related pathologies and, therefore, to women's health. ..
  5. Inhibition of Alzheimer's Beta-Amyloid Fibril Formation
    Duy Hua; Fiscal Year: 2009
    ..However, soluble oligomeric Abeta showed high neuronal toxicity. Inhibition of the formation of these toxic soluble Abeta oligomers would provide therapeutics for AD. ..
  6. Biliary and Intestinal Cell Models of Drug Toxicity
    MARY KANZ; Fiscal Year: 2004
    ..The basic techniques developed in this research will lead to new methods for screening potential drug injury to target sites that are not easily investigated in vivo. ..
  7. Palladium- and Nickel-Catalyzed C-C Bond Formation
    GREGORY FU; Fiscal Year: 2009
    ..Mechanistic studies will play an important role in this project, since an improved understanding of metal-based reactivity should greatly facilitate catalyst development. ..
  8. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  9. SIGNALING PATHWAYS IN CHEMICAL INDUCED OVOTOXICITY
    Patricia B Hoyer; Fiscal Year: 2010
    ..This will lead to an appreciation of the global impact of the environment on the reproductive life span in women. ..
  10. Synthesis of Tumor Inhibitory Marine Natural Products
    James Marshall; Fiscal Year: 2004
    ..The main chemical issues to be addressed include the control of stereochemistry by means of chiral organometal chemistry and the design of new and efficient routes to structurally novel natural products. ..
  11. Asymmetric Catalysis by Transition Metals
    GREGORY FU; Fiscal Year: 2006
    ..unreadable] [unreadable] the application of these new ligands to the development of highly enantioselective transition metal-catalyzed reactions. [unreadable] [unreadable]..
  12. ENVIRONMENTAL EPOXIDES--MECHANISMS OF OVOTOXICITY
    Patricia Hoyer; Fiscal Year: 2002
    ..The results of these studies will provide greater insight as to the impact of exposure to ovotoxic environmental chemicals on reproductive health in women. ..
  13. SYNTHESIS OF ANNONACEOUS ACETOGENINS AND ANALOGUES
    James Marshall; Fiscal Year: 2001
    ..The synthetic approach will employ chiral allylic and allenic organometal reagents to introduce stereogenic centers with concurrent formation of carbon-carbon bonds. ..
  14. 2006 Drinking Water Disinection By-Product (DBP) Gordon Conference
    Susan Richardson; Fiscal Year: 2006
    ..Issues to be covered include new reproductive/developmental toxicological issues, human exposure, chemistry of formation, and remaining cancer issues. [unreadable] [unreadable] [unreadable] [unreadable]..
  15. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  16. BEHAVIORAL ANALYSIS OF OMPS ROLE IN ODOR PROCESSING
    STEVEN YOUNGENTOB; Fiscal Year: 2003
    ..e., at the transduction level) and may provide insight into a therapeutic strategy that has implications for a variety of neurological disorders. ..
  17. DEVELOPING A RAPID SCREEN TO DETECT OLFACTORY MUTANTS
    STEVEN YOUNGENTOB; Fiscal Year: 2001
    ..For each phase, we will provide detailed information via a Web-based database linked to centralized resources. ..
  18. In utero ethanol experience and olfactory plasticity
    Steven L Youngentob; Fiscal Year: 2010
    ..It will also establish a chemosensory related conceptual framework of fetal exposure with broad based importance in child development and drug abuse. ..