pyrethrins

Summary

Summary: The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester.

Top Publications

  1. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
  2. pmc Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
    Sara N Mitchell
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 109:6147-52. 2012
  3. pmc Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, UK
    Malar J 8:299. 2009
  4. pmc Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom
    Genome Res 19:452-9. 2009
  5. ncbi Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed
    Bradley J Stevenson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 41:492-502. 2011
  6. pmc Dramatic decrease in malaria transmission after large-scale indoor residual spraying with bendiocarb in Benin, an area of high resistance of Anopheles gambiae to pyrethroids
    Martin Akogbeto
    Centre de Recherche Entomologique de Cotonou, Benin
    Am J Trop Med Hyg 85:586-93. 2011
  7. ncbi The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso
    Abdoulaye Diabate
    Laboratoire d Entomologie et de Parasitologie, Centre Muraz, Bobo Dioulasso, Burkina Faso
    Am J Trop Med Hyg 67:617-22. 2002
  8. ncbi Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon
    Pie Müller
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Mol Ecol 17:1145-55. 2008
  9. ncbi Susceptibility status of malaria vectors to insecticides commonly used for malaria control in Tanzania
    Bilali Kabula
    National Institute for Medical Research, Amani Research Centre, Muheza, Tanzania
    Trop Med Int Health 17:742-50. 2012
  10. ncbi Safety of pyrethroid-treated mosquito nets
    M Zaim
    World Health Organization Pesticides Evaluation Scheme, Strategy Development and Monitoring of Parasitic Diseases and Vector Control, Communicable Diseases Control Prevention and Eradication World Health Organization, Geneva, Switzerland
    Med Vet Entomol 14:1-5. 2000

Detail Information

Publications328 found, 100 shown here

  1. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
    ..As we move into the malaria eradication era, it is vital that the implications of insecticide resistance are understood and strategies to mitigate these effects are implemented...
  2. pmc Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
    Sara N Mitchell
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 109:6147-52. 2012
    ..Using in vitro assays we show that recombinant CYP6M2 is also capable of metabolizing the organochlorine insecticide DDT in the presence of solubilizing factor sodium cholate...
  3. pmc Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, UK
    Malar J 8:299. 2009
    ..The current extent and distribution of this resistance in many parts of the continent is unknown and yet such information is essential for the planning of effective malaria control interventions...
  4. pmc Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom
    Genome Res 19:452-9. 2009
    ..This will be a major advance for insecticide resistance management in malaria vectors, which requires the early detection of resistance alleles...
  5. ncbi Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed
    Bradley J Stevenson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 41:492-502. 2011
    ..gambiae, consistent with a role in detoxification. Our data indicates that CYP6M2 plays an important role in metabolic resistance to pyrethroids and thus an important target for the design of new tools to combat malaria...
  6. pmc Dramatic decrease in malaria transmission after large-scale indoor residual spraying with bendiocarb in Benin, an area of high resistance of Anopheles gambiae to pyrethroids
    Martin Akogbeto
    Centre de Recherche Entomologique de Cotonou, Benin
    Am J Trop Med Hyg 85:586-93. 2011
    ..Bendiocarb was found to be a good alternative insecticide for IRS in Benin, in areas where An. gambiae has developed high resistance to pyrethroids...
  7. ncbi The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso
    Abdoulaye Diabate
    Laboratoire d Entomologie et de Parasitologie, Centre Muraz, Bobo Dioulasso, Burkina Faso
    Am J Trop Med Hyg 67:617-22. 2002
    ..Pyrethroid resistance in west African An. gambiae was conferred by target site insensitivity through a knockdown resistance (kdr)-like mutation, which was present at high frequencies in mosquitoes in the cotton-growing and urban areas...
  8. ncbi Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon
    Pie Müller
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Mol Ecol 17:1145-55. 2008
    ..These genes may constitute an important general defence mechanism against insecticides. Intriguingly, the levels of expression of these genes were strongly correlated suggesting a common regulatory mechanism...
  9. ncbi Susceptibility status of malaria vectors to insecticides commonly used for malaria control in Tanzania
    Bilali Kabula
    National Institute for Medical Research, Amani Research Centre, Muheza, Tanzania
    Trop Med Int Health 17:742-50. 2012
    ..The aim of the study was to monitor the insecticide susceptibility status of malaria vectors in 12 sentinel districts of Tanzania...
  10. ncbi Safety of pyrethroid-treated mosquito nets
    M Zaim
    World Health Organization Pesticides Evaluation Scheme, Strategy Development and Monitoring of Parasitic Diseases and Vector Control, Communicable Diseases Control Prevention and Eradication World Health Organization, Geneva, Switzerland
    Med Vet Entomol 14:1-5. 2000
    ..Because many domestic users of pyrethroid 'home treatment kits' for ITNs may not be fully literate, it is essential that 'instructions for use' should be portrayed via pictograms with supporting text in appropriate local language(s)...
  11. ncbi Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
    Martin J Donnelly
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, UK
    Trends Parasitol 25:213-9. 2009
    ..However, we emphasize that kdr genotype might explain only a portion of heritable variation in resistance and that diagnostic assays to test the importance of other resistance mechanisms in field populations are required...
  12. pmc Long-term field performance of a polyester-based long-lasting insecticidal mosquito net in rural Uganda
    Albert Kilian
    Malaria Consortium, Development House, 56 64 Leonard Street EC2A 4JX, London, UK
    Malar J 7:49. 2008
    ....
  13. pmc Aging partially restores the efficacy of malaria vector control in insecticide-resistant populations of Anopheles gambiae s.l. from Burkina Faso
    Christopher M Jones
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Malar J 11:24. 2012
    ..In this study, LLINs and IRS were tested against young (three to five days) and old (17-19 days) pyrethroid resistant Anopheles gambiae s.l. from Burkina Faso...
  14. pmc Multimodal pyrethroid resistance in malaria vectors, Anopheles gambiae s.s., Anopheles arabiensis, and Anopheles funestus s.s. in western Kenya
    Hitoshi Kawada
    Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    PLoS ONE 6:e22574. 2011
    ..Similarly, the metabolic pyrethroid resistance in An. arabiensis and An. funestus s.s. is thought to develop without strong selection by DDT...
  15. pmc Detection of knockdown resistance (kdr) mutations in Anopheles gambiae: a comparison of two new high-throughput assays with existing methods
    Chris Bass
    Department of Biological Chemistry, Rothamsted Research, Harpenden, UK
    Malar J 6:111. 2007
    ..However, there are few reports comparing the performance of these different assays. In this study, two new high-throughput assays were developed and compared with four established techniques...
  16. ncbi Do insecticide-treated bednets have an effect on malaria vectors?
    Willem Takken
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Trop Med Int Health 7:1022-30. 2002
    ..Examples are presented in which untreated nets provided a reasonable degree of protection against malaria...
  17. pmc Detoxification enzymes associated with insecticide resistance in laboratory strains of Anopheles arabiensis of different geographic origin
    Luisa Nardini
    Vector Control Reference Unit, Centre for Opportunistic, Tropical and Hospital Infections, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
    Parasit Vectors 5:113. 2012
    ..The aim of this study was to investigate the detoxification enzymes that are involved in An. arabiensis resistance to DDT and pyrethroids...
  18. ncbi An experimental hut evaluation of PermaNet(®) 3.0, a deltamethrin-piperonyl butoxide combination net, against pyrethroid-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in southern Benin
    Raphael N'Guessan
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E7HT, UK
    Trans R Soc Trop Med Hyg 104:758-65. 2010
    ..Against C. quinquefasciatus, no treatment killed >24% entering the huts. The synergism from unwashed PermaNet 3.0 was lower than expected, probably due to an unidentified resistance mechanism unaffected by PBO...
  19. pmc Pyrethroid resistance in an Anopheles funestus population from Uganda
    John C Morgan
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS ONE 5:e11872. 2010
    ..Here we report the susceptibility status of the An. funestus population from Tororo district in Uganda and a preliminary characterisation of the putative resistance mechanisms involved...
  20. pmc Occurrence of the leucine-to-phenylalanine knockdown resistance (kdr) mutation in Anopheles arabiensis populations in Tanzania, detected by a simplified high-throughput SSOP-ELISA method
    Manisha A Kulkarni
    Department of Natural Resource Sciences, McGill University, Macdonald Campus, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    Malar J 5:56. 2006
    ..Knockdown resistance (kdr) confers resistance to the pyrethroid class of insecticides with cross-resistance to DDT through single nucleotide polymorphisms (SNPs) in the voltage-gated sodium channel gene...
  21. ncbi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009
    ..Intriguingly, the association between DDT resistance and the presence of L1014S is consistent with a co-dominant effect, with heterozygous individuals showing an intermediate phenotype...
  22. ncbi Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)
    B D Brooke
    Medical Entomology, Department of Clinical Microbiology and Infectious Diseases, School of Pathology of the South African Institute for Medical Research, Johannesburg, 2000, South Africa
    Bull Entomol Res 91:265-72. 2001
    ..The data suggested that this mechanism was also conferring cross-resistance to the carbamate insecticide propoxur...
  23. ncbi Changes in house design reduce exposure to malaria mosquitoes
    S W Lindsay
    Institute of Ecosystem Science, School of Biological and Biomedical Sciences, University of Durham, UK
    Trop Med Int Health 8:512-7. 2003
    ..Ceilings are likely to be well accepted and may be of greatest benefit in areas of low to moderate transmission and when used in combination with other malaria control strategies...
  24. pmc Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens
    J G Vontas
    School of Biosciences, Cardiff University, Main College, Museum Avenue, P O Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 357:65-72. 2001
    ..lugens is through protecting tissues from oxidative damage. Our study extends the GSTs' range of efficacy to pyrethroid insecticides and possibly explains the role of elevated GSTs in other pyrethroid-resistant insects...
  25. pmc Reduced efficacy of insecticide-treated nets and indoor residual spraying for malaria control in pyrethroid resistance area, Benin
    Vincent Corbel
    London School of Hygiene and Tropical Medicine, Cotonou, Benin, West Africa
    Emerg Infect Dis 13:199-206. 2007
    ..Pyrethroid resistance in An. gambiae appears to threaten the future of ITN and IRS in Benin...
  26. pmc Pyrethroid resistance in Aedes aegypti from Grand Cayman
    Angela F Harris
    The Mosquito Research and Control Unit, Grand Cayman, Cayman Islands, British West Indies
    Am J Trop Med Hyg 83:277-84. 2010
    ..The F1534C mutation was strongly correlated with resistance to DDT and permethrin...
  27. pmc Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe
    Dorothee Stanneck
    Bayer Animal Health GmbH BAH, Monheim, Germany
    Parasit Vectors 5:66. 2012
    ....
  28. ncbi The effect of piperonyl butoxide on pyrethroid-resistance-associated esterases in Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)
    Susan J Young
    Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK
    Pest Manag Sci 61:397-401. 2005
    ..It would also be expected that restoration of efficacy with other conventional insecticides, currently compromised by esterase-based resistance mechanisms, would occur...
  29. ncbi Modifications of pyrethroid effects associated with kdr mutation in Anopheles gambiae
    F Chandre
    Laboratoire de Lutte contre les Insectes Nuisibles, Institute for Research and Development IRD formerly ORSTOM, Montpellier, France
    Med Vet Entomol 14:81-8. 2000
    ..8.1% of Yao R (P<0.05). Nets treated with deltamethrin 25 mg/m2 caused mortality rates of 91% Kisumu SS and 54% Yao R (P<0.001) and reduced blood-feeding rates to zero for SS vs. 2.5% for Yao R (P>0.05). (ABSTRACT TRUNCATED)..
  30. ncbi Relationship between kdr mutation and resistance to pyrethroid and DDT insecticides in natural populations of Anopheles gambiae
    Lisa Reimer
    Department of Entomology and Center for Vectorborne Diseases, University of California Davis, Davis, CA 95616, USA
    J Med Entomol 45:260-6. 2008
    ..Kdr-w conferred greater resistance to permethrin than kdr-e. We also describe a modified diagnostic designed to detect both resistant alleles simultaneously...
  31. ncbi Poisoning due to pyrethroids
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre, City Hospital, UK
    Toxicol Rev 24:93-106. 2005
    ..Management is supportive. As paraesthesiae usually resolve in 12-24 hours, specific treatment is not generally required, although topical application of dl-alpha tocopherol acetate (vitamin E) may reduce their severity...
  32. ncbi Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the voltage-gated sodium channel gene
    C Brengues
    Laboratoire de Lutte contre les Insectes Nuisibles, Institut de Recherche pour le Developpment, Montpellier, France
    Med Vet Entomol 17:87-94. 2003
    ..Direct neurophysiological assays on individual larvae from three strains with these mutations demonstrated reduced nerve sensitivity to permethrin or lambda cyhalothrin inhibition compared to the susceptible strains...
  33. pmc Field efficacy of a new mosaic long-lasting mosquito net (PermaNet 3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central Africa
    Vincent Corbel
    Institut de Recherche pour le Developpement, UR016, Caractérisation et Contrôle des Populations de Vecteurs, 01 BP 4414 RP Cotonou, Republique du Benin
    Malar J 9:113. 2010
    ..The aim of this study was to evaluate the performances of a new mosaic long-lasting insecticidal net (LLIN), i.e. PermaNet 3.0, against wild pyrethroid-resistant Anopheles gambiae s.l. in West and Central Africa...
  34. ncbi Distribution of pyrethroid and DDT resistance and the L1014F kdr mutation in Anopheles gambiae s.l. from Burkina Faso (West Africa)
    K R Dabire
    Insitut de Recherche en Science de la Santé IRSS Centre Muraz, BP 390, Bobo Dioulasso, Burkina Faso
    Trans R Soc Trop Med Hyg 103:1113-20. 2009
    ..The frequency of kdr was also found to have increased in An. arabiensis populations (0.28), where it was formerly reported in only a single specimen. These results have practical significance for malaria vector control programs...
  35. ncbi A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti
    K Saavedra-Rodriguez
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Insect Mol Biol 16:785-98. 2007
    ..The tools and information presented provide a means for early detection and characterization of kdr that is critical to the development of strategies for resistance management...
  36. pmc Development of vegetable farming: a cause of the emergence of insecticide resistance in populations of Anopheles gambiae in urban areas of Benin
    Anges William M Yadouleton
    Centre de Recherche Entomologique de Cotonou, Benin
    Malar J 8:103. 2009
    ..This study aims to assess the rapid expansion of urban agriculture especially, its contribution to the emergence of insecticide resistance in populations of Anopheles gambiae...
  37. ncbi DDT, pyrethrins, pyrethroids and insect sodium channels
    T G E Davies
    Biological Chemistry Division, Rothamsted Research, Hertfordshire, UK
    IUBMB Life 59:151-62. 2007
    ..DDT, the pyrethrins and the synthetic pyrethroids (the latter currently accounting for around 17% of the world insecticide market), ..
  38. pmc Evaluation of PermaNet 3.0 a deltamethrin-PBO combination net against Anopheles gambiae and pyrethroid resistant Culex quinquefasciatus mosquitoes: an experimental hut trial in Tanzania
    Patrick Tungu
    Amani Medical Research Centre, National Institute for Medical Research, Muheza, Tanzania
    Malar J 9:21. 2010
    ..PBO is an inhibitor of mixed function oxidases implicated in pyrethroid resistance...
  39. pmc Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin
    Corine Ngufor
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 10:343. 2011
    ..The combining of IRS and LLINs presents an opportunity for improved control and management of pyrethroid resistance through the simultaneous presentation of unrelated insecticides...
  40. pmc Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance
    Bradley J Stevenson
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 6:e1595. 2012
    ..Our aim was to confirm the role of CYP9J32 and other P450s in insecticide metabolism in order to identify potential diagnostic resistance markers...
  41. ncbi A significant increase in kdr in Anopheles gambiae is associated with an intensive vector control intervention in Burundi highlands
    Natacha Protopopoff
    Department of Parasitology, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 13:1479-87. 2008
    ..l.) was determined for six consecutive years within the framework of a vector control programme. Findings were also linked with the insecticide resistance status observed with bioassay in An. gambiae s.l. and An. funestus...
  42. pmc Comparison of house spraying and insecticide-treated nets for malaria control
    C F Curtis
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, England
    Bull World Health Organ 78:1389-400. 2000
    ..The importance of high population coverage is emphasized, and the advantages of providing treatment free of charge, rather than charging individuals, are pointed out...
  43. pmc Bio-efficacy of selected long-lasting insecticidal nets against pyrethroid resistant Anopheles arabiensis from South-Western Ethiopia
    Delenasaw Yewhalaw
    Department of Biology, College of Natural Sciences, Jimma University, Jimma, Ethiopia
    Parasit Vectors 5:159. 2012
    ..s. and Anopheles arabiensis may compromise control initiatives based on insecticide-treated nets (ITNs) or indoor residual spraying (IRS), and thus threaten the global malaria elimination strategy...
  44. pmc Impact of insecticide-treated nets on wild pyrethroid resistant Anopheles epiroticus population from southern Vietnam tested in experimental huts
    Wim Van Bortel
    Institute of Tropical Medicine, Dept Parasitology, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Malar J 8:248. 2009
    ....
  45. ncbi Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids
    H Ranson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA
    Insect Mol Biol 9:491-7. 2000
    ..The An. gambiae sodium channel was physically mapped to chromosome 2L, division 20C. This position corresponds to the location of a major quantitative trait locus determining resistance to permethrin in the Kenyan strain of An. gambiae...
  46. pmc A new classification system for the actions of IRS chemicals traditionally used for malaria control
    John P Grieco
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 2:e716. 2007
    ..The new classification scheme will characterize chemicals on the basis of spatial repellent, contact irritant and toxic actions...
  47. ncbi Anopheles arabiensis and An. quadriannulatus resistance to DDT in South Africa
    K Hargreaves
    Malaria Control Programme, KwaZulu Natal Department of Health, Jozini, South Africa
    Med Vet Entomol 17:417-22. 2003
    ..funestus Giles, indicates an urgent need to develop a strategy of insecticide resistance management for the malaria control programmes of southern Africa...
  48. pmc An experimental hut evaluation of Olyset nets against anopheline mosquitoes after seven years use in Tanzanian villages
    Robert C Malima
    London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Malar J 7:38. 2008
    ..It has not been determined for how long Olyset nets remain protective against mosquitoes in household use...
  49. ncbi An adult-specific CYP6 P450 gene is overexpressed in a pyrethroid-resistant strain of the malaria vector, Anopheles gambiae
    Dimitra Nikou
    Vector Biology Division, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Gene 318:91-102. 2003
    ..The isolation of An. gambiae cDNAs encoding cytochrome b(5) and nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH)-cytochrome P450 reductase cDNAs is also reported...
  50. ncbi Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria
    T S Awolola
    Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria
    Trans R Soc Trop Med Hyg 103:1139-45. 2009
    ..Two of these, CPLC8 and CPLC#, are cuticular genes not implicated in pyrethroid metabolism in An. gambiae s.s, and could constitute a novel set of candidate genes that warrant further investigation...
  51. pmc Analysis of Anopheles arabiensis blood feeding behavior in southern Zambia during the two years after introduction of insecticide-treated bed nets
    Christen M Fornadel
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 83:848-53. 2010
    ..Anopheles arabiensis mosquitoes in Macha appear to be relatively exophagic and have been caught biting outdoors immediately after sunset and before sunrise, potentially circumventing some of the protective effects of ITNs...
  52. ncbi Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment
    David M Soderlund
    Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    Toxicology 171:3-59. 2002
    ....
  53. pmc Effective control of dengue vectors with curtains and water container covers treated with insecticide in Mexico and Venezuela: cluster randomised trials
    Axel Kroeger
    Special Programme for Research and Training in Tropical Medicine TDR WHO, World Health Organization, Geneva, Switzerland
    BMJ 332:1247-52. 2006
    ..To measure the impact on the dengue vector population (Aedes aegypti) and disease transmission of window curtains and water container covers treated with insecticide...
  54. ncbi Frequency of Val1016Ile mutation in the voltage-gated sodium channel gene of Aedes aegypti Brazilian populations
    Ademir Jesus Martins
    Laboratório de Fisiologia e Controle de Artrópodes Vetores, Rio de Janeiro, Brazil
    Trop Med Int Health 14:1351-5. 2009
    ..Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil...
  55. pmc High level of pyrethroid resistance in an Anopheles funestus population of the Chokwe District in Mozambique
    Nelson Cuamba
    National Institute of Health, Maputo, Mozambique
    PLoS ONE 5:e11010. 2010
    ..funestus from Mozambique in order to analyse its susceptibility status to insecticides and to broadly characterise the main resistance mechanisms involved in natural populations...
  56. pmc Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin
    Georgia B Damien
    Centre de Recherche Entomologique de Cotonou CREC, 06 BP 2604 Cotonou, Benin
    Malar J 9:380. 2010
    ..The burden of malaria was estimated in terms of infection (prevalence and parasite density) and of clinical episodes...
  57. ncbi Synergistic interactions between in-hive miticides in Apis mellifera
    Reed M Johnson
    Department of Entomology, 320 Morrill Hall, University of Illinois, 505 S Goodwin, Urbana, IL 61801 3795, USA
    J Econ Entomol 102:474-9. 2009
    ..These results suggest that honey bee mortality may occur with the application of otherwise sublethal doses of miticide when tau-fluvalinate and coumaphos are simultaneously present in the hive...
  58. pmc Insecticide resistance status in Anopheles gambiae in southern Benin
    Anges W Yadouleton
    Centre de Recherche Entomologique de Cotonou CREC, 06 BP 2604 Cotonou, Republique du Benin
    Malar J 9:83. 2010
    ..It is, therefore, crucial to monitor the level and type of insecticide resistance in An. gambiae, particularly in southern Benin where reduced efficacy of insecticide-treated nets (ITNs) and IRS has previously been reported...
  59. ncbi Over expression of a cytochrome P450 (CYP6P9) in a major African malaria vector, Anopheles Funestus, resistant to pyrethroids
    D A Amenya
    Vector Control Reference Unit, National Institute for Communicable Diseases, NHLS, Private bag X 4, Sandringham, 2131, South Africa
    Insect Mol Biol 17:19-25. 2008
    ..This gene is genetically linked to a major locus associated with pyrethroid resistance in this A. funestus population...
  60. pmc A simplified high-throughput method for pyrethroid knock-down resistance (kdr) detection in Anopheles gambiae
    Amy Lynd
    Vector Research Group, Liverpool Tropical School of Medicine, Pembroke Place, Liverpool, UK
    Malar J 4:16. 2005
    ..Here we present a reliable and potentially high throughput method for screening An. gambiae for the kdr mutation...
  61. ncbi Increased transcription of CYP6D1 causes cytochrome P450-mediated insecticide resistance in house fly
    N Liu
    Department of Entomology, Cornell University, Ithaca, New York 14853 0901, USA
    Insect Biochem Mol Biol 28:531-5. 1998
    ..The increased rate of transcription of CYP6D1 in the resistant strain (LPR) is controlled by two factors: one on autosome 1 and another on autosome 2...
  62. ncbi Glutathione S-transferase in the defence against pyrethroids in insects
    I Kostaropoulos
    Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, 54006, Thessaloniki, Greece
    Insect Biochem Mol Biol 31:313-9. 2001
    ..According to this, GST offers a passive protection towards pyrethroid insecticides by binding to their molecule in a sequestering mechanism...
  63. ncbi Insecticide resistance in vector mosquitoes in China
    Feng Cui
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Pest Manag Sci 62:1013-22. 2006
    ....
  64. pmc Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs
    Timothy J Shafer
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 113:123-36. 2005
    ..These studies should employ state-of-the-science methods to promote a greater understanding of the mode of action of pyrethroids in the developing nervous system...
  65. pmc Transcription profiling of a recently colonised pyrethroid resistant Anopheles gambiae strain from Ghana
    Pie Müller
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    BMC Genomics 8:36. 2007
    ..Although three enzyme families (cytochrome P450s, glutathione S-transferases and carboxylesterases) have been widely associated with insecticide detoxification the role of individual enzymes is largely unknown...
  66. ncbi Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases
    Matthew K Ross
    Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, PO Box 6100 Mississippi State, MS 39762 6100, USA
    Biochem Pharmacol 71:657-69. 2006
    ..While there are likely other esterases in human liver that hydrolyze pyrethroids, the results of this study clearly demonstrate that hCE-1 and hCE-2 are human pyrethroid-hydrolyzing CEs...
  67. pmc Impact of three years of large scale Indoor Residual Spraying (IRS) and Insecticide Treated Nets (ITNs) interventions on insecticide resistance in Anopheles gambiae s.l. in Benin
    Gil Germain Padonou
    Faculté des Sciences et Techniques de l Université d Abomey Calavi, Calavi, Benin
    Parasit Vectors 5:72. 2012
    ..We assessed the impact of this campaign on phenotypic resistance, kdr (knock-down resistance) and ace-1(R) (insensitive acetylcholinesterase) mutations...
  68. pmc Deep sequencing of pyrethroid-resistant bed bugs reveals multiple mechanisms of resistance within a single population
    Zach N Adelman
    Fralin Life Science Institute and Department of Entomology, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 6:e26228. 2011
    ..These data will accelerate efforts to understand the biochemical basis for insecticide resistance in bed bugs, and provide molecular markers to assist in the surveillance of metabolic resistance...
  69. ncbi The efficacy of collars impregnated with flumethrin and propoxur against experimental infestations of adult Rhipicephalus sanguineus on dogs
    L J Fourie
    Department of Zoology and Entomology, University of the Free State, PO Box 339, Bloemfontein 9301, South Africa
    J S Afr Vet Assoc 74:123-6. 2003
    ..The mean tick counts on the 2 groups of collared dogs did not differ significantly (P < 0.0001) for any of the assessment days...
  70. pmc The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats
    Dorothee Stanneck
    Bayer Animal Health GmbH, Leverkusen, Germany
    Parasit Vectors 5:73. 2012
    ..A new polymer matrix collar has recently been developed which is registered for 8 months use in cats and dogs. The basic properties of this collar have been investigated in several in vitro and in vivo studies...
  71. ncbi Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling
    Tg Emyr Davies
    Biological Chemistry Department, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Pest Manag Sci 64:1126-30. 2008
    ....
  72. ncbi Widespread distribution of knockdown resistance mutations in the bed bug, Cimex lectularius (Hemiptera: Cimicidae), populations in the United States
    Fang Zhu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, Kentucky 40546, USA
    Arch Insect Biochem Physiol 73:245-57. 2010
    ..These data suggest that deltamethrin resistance conferred by target-site insensitivity of sodium channel is widely spread in bed bug populations across the United States...
  73. pmc Malaria transmission in Dakar: a two-year survey
    Frederic Pages
    Unité d entomologie médicale, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France
    Malar J 7:178. 2008
    ..However; there was some evidence of local transmission based on reports of malaria among permanent residents. An entomological evaluation of malaria transmission was conducted from May 2005 to October 2006 in two areas of Dakar...
  74. pmc Control of pyrethroid and DDT-resistant Anopheles gambiae by application of indoor residual spraying or mosquito nets treated with a long-lasting organophosphate insecticide, chlorpyrifos-methyl
    Raphael N'Guessan
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:44. 2010
    ..Dow Agrosciences have developed a microencapsulated formulation (CS) of the organophosphate chlorpyrifos methyl as a cost-effective, long-lasting alternative to DDT...
  75. ncbi Insecticide resistance in the bed bug: a factor in the pest's sudden resurgence?
    Alvaro Romero
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    J Med Entomol 44:175-8. 2007
    ..Without the development of new tactics for bed bug management, further escalation of this public health problem should be expected...
  76. ncbi The kdr mutation occurs in the Mopti form of Anopheles gambiae s.s. through introgression
    M Weill
    Institut des Sciences de l Evolution UMR 5554, Laboratoire Genetique et Environnement, Universite Montpellier II, Montpellier, France
    Insect Mol Biol 9:451-5. 2000
    ..These results are discussed within the context of possible gene flow between members of An. gambiae s.s. taxa, and with the possible spread of the kdr mutation in other closely related malaria vectors of the An. gambiae complex...
  77. pmc Insecticide resistance in Aedes aegypti populations from Ceará, Brazil
    Estelita Pereira Lima
    Universidade Federal do Ceará Avenida da Universidade, 2853, CEP 60020 181, Benfica, Fortaleza CE, Brasil
    Parasit Vectors 4:5. 2011
    ..Here we measure resistance to temephos and the pyrethroid cypermethrin in three populations from Ceará and use biochemical and molecular assays to characterise resistance mechanisms...
  78. ncbi Experimental hut comparisons of nets treated with carbamate or pyrethroid insecticides, washed or unwashed, against pyrethroid-resistant mosquitoes
    A N Asidi
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Med Vet Entomol 18:134-40. 2004
    ..After five washes, the Permanet, which is sold as a long-lasting insecticidal product, performed no better than the other nets in our experimental conditions...
  79. pmc Trends in DDT and pyrethroid resistance in Anopheles gambiae s.s. populations from urban and agro-industrial settings in southern Cameroon
    Philippe Nwane
    Organisation de Coordination pour la Lutte Contre les Endemies en Afrique Centrale, Yaounde, Cameroun
    BMC Infect Dis 9:163. 2009
    ..This study highlights trends in DDT and pyrethroid resistance in wild An. gambiae populations from South Cameroon...
  80. ncbi Less is more: restricted application of insecticide to cattle to improve the cost and efficacy of tsetse control
    S J Torr
    Natural Resources Institute, University of Greenwich, Chatham Maritime, UK
    Med Vet Entomol 21:53-64. 2007
    ..This would cut the cost of insecticide by 40%, improve efficacy by 27% and reduce the threats to non-target organisms and the enzootic stability of tick-borne diseases...
  81. pmc Evaluation of Interceptor long-lasting insecticidal nets in eight communities in Liberia
    Kristin Banek
    Uganda Malaria Surveillance Project, PO Box 7475, Kampala, Uganda
    Malar J 9:84. 2010
    ..Field information is available for both Olyset(R) and PermaNet((R)), with limited data on the newer LLINs. To address this gap, a field evaluation was carried out to determine the acceptability and durability of Interceptor((R)) LLINs...
  82. ncbi Differential expression of genes in pyrethroid resistant and susceptible mosquitoes, Culex quinquefasciatus (S.)
    Nannan Liu
    Department of Entomology and Plant Pathology, Auburn University, Auburn AL 36849, USA
    Gene 394:61-8. 2007
    ..Functional studies of resistance-associated up-regulated genes should shed new light on both the molecular basis of resistance and the regulatory pathways that lead to it...
  83. pmc Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa
    Federica Santolamazza
    Istituto Pasteur Fondazione Cenci Bolognetti, Universita La Sapienza, Rome, Italy
    Malar J 7:74. 2008
    ..In M-form populations surveyed to date, only the L1014F mutation has been found, although less widespread and at lower frequencies than in sympatric S-form populations...
  84. pmc Malaria vector control by indoor residual insecticide spraying on the tropical island of Bioko, Equatorial Guinea
    Brian L Sharp
    Malaria Research Lead Programme, Medical Research Council, Durban, South Africa
    Malar J 6:52. 2007
    ..This manuscript reports on the continuous entomological monitoring of the indoor residual spray (IRS) programme during the first two years of its implementation...
  85. pmc Monooxygenase levels and knockdown resistance (kdr) allele frequencies in Anopheles gambiae and Anopheles arabiensis in Kenya
    Hong Chen
    Program in Public Health, College of Health Sciences, University of California, Irvine, CA 92697, USA
    J Med Entomol 45:242-50. 2008
    ....
  86. ncbi Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT
    P N R Usherwood
    School of Biology, The University of Nottingham, University Park, Nottingham, UK
    FEBS Lett 581:5485-92. 2007
    ..DDT potency was unaffected by M918T, but abolished by T929I and reduced by L925I, L932F and I936V, suggesting that DIIS5 contains at least part of the DDT binding domain. The data support a computer model of pyrethroid and DDT binding...
  87. ncbi Disrupting effects of bifenthrin on ovulatory gene expression and prostaglandin synthesis in rat ovarian granulosa cells
    Jing Liu
    MOE Key Lab of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, People s Republic of China
    Toxicology 282:47-55. 2011
    ....
  88. ncbi Multiple origins of pyrethroid resistance in sympatric biotypes of Bemisia tabaci (Hemiptera: Aleyrodidae)
    Michal Alon
    Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Insect Biochem Mol Biol 36:71-9. 2006
    ..Although the B and Q biotypes coexist in several regions of the Mediterranean basin, divergence in their DNA sequences at the para-type voltage gated sodium channel locus suggests gene flow between these biotypes is low or nil...
  89. ncbi Sublethal effects of four insecticides on the reproduction and wing formation of brown planthopper, Nilaparvata lugens
    Haibo Bao
    Key Laboratory of Monitoring and Management of Plant Disease and Insects, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China
    Pest Manag Sci 65:170-4. 2009
    ..Here, the effects of sublethal doses of these four insecticides on the reproduction and wing formation in BPH were examined...
  90. ncbi Impact of insecticide-treated bed nets implementation on the genetic structure of Anopheles arabiensis in an area of irrigated rice fields in the Sahelian region of Cameroon
    C Wondji
    Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la Lutte Contre les Endemies en Afrique Centrale, PO Box 288, Yaounde, Cameroon
    Mol Ecol 14:3683-93. 2005
    ..arabiensis population suggests that, to optimize the success of any control programme of this species based on ITNs, the control area should be very large and the programme should be implemented for a long period of time...
  91. ncbi Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips tabaci (Thysanoptera: Thripidae)
    Satoshi Toda
    Grape and Persimmon Research Station, National Institute of Fruit Tree Science, Higashihiroshima, Hiroshima, Japan
    J Econ Entomol 102:2296-300. 2009
    ..A moderately resistant strain was homozygous for the T929I mutation. This is the first report to identify these three major mutations within the same species...
  92. ncbi Environmental context determines community sensitivity of freshwater zooplankton to a pesticide
    Nathalie C Stampfli
    Department of System Ecotoxicology, Helmholtz Centre for Environmental Research UFZ, Permoserstraße 15, 04318 Leipzig, Germany
    Aquat Toxicol 104:116-24. 2011
    ..These findings indicate that environmental context is more important for ecotoxicological evaluation than assumed previously...
  93. pmc Effect of insecticide resistance on development, longevity and reproduction of field or laboratory selected Aedes aegypti populations
    Ademir Jesus Martins
    Laboratório de Fisiologia e Controle de Artrópodes Vetores, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 7:e31889. 2012
    ....
  94. pmc Efficacy of an imidacloprid/flumethrin collar against fleas, ticks, mites and lice on dogs
    Dorothee Stanneck
    Bayer HealthCare AG, Animal Health Division, 51368 Leverkusen, Germany
    Parasit Vectors 5:102. 2012
    ....
  95. ncbi Pyrethroid and organophosphorus pesticides in composite diet samples from Atlanta, USA adults
    Anne M Riederer
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, Georgia 30322, USA
    Environ Sci Technol 44:483-90. 2010
    ..Results show frequent dietary exposure of our participants to the target pesticides from a range of food types...
  96. pmc Predictors of Plasmodium falciparum malaria incidence in Chano Mille, South Ethiopia: a longitudinal study
    Eskindir Loha
    School of Public and Environmental Health, Hawassa University, Ethiopia
    Am J Trop Med Hyg 87:450-9. 2012
    ..Although ITNs prevented falciparum malaria for the users, we did not find that free mass ITNs distribution reduced falciparum malaria on a village level...
  97. ncbi Can piperonyl butoxide enhance the efficacy of pyrethroids against pyrethroid-resistant Aedes aegypti?
    Georgina Bingham
    Innovation Centre, Vestergaard Frandsen, Lausanne, Switzerland
    Trop Med Int Health 16:492-500. 2011
    ..This enhancement stems from its ability to inhibit two major metabolic enzyme systems, P450s and non-specific esterases, and to enhance cuticular penetration of the insecticide...
  98. ncbi In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450 isoforms
    Edward J Scollon
    United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina 27711, USA
    Drug Metab Dispos 37:221-8. 2009
    ..These species differences and isomer interactions in metabolism of pyrethroids should be considered when assessing the potential adverse health effects of pyrethroid pesticides...
  99. ncbi Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA
    Asa Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
    J Expo Sci Environ Epidemiol 17:331-49. 2007
    ..The child activity timeline, a novel, low-literacy instrument based on pictures, was successfully used by our participants. Future uses of these data include the development of pesticide exposure models and risk assessment...
  100. pmc Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon
    Jean Romain Mourou
    Departement de Parasitologie Mycologie, Faculte de Medecine, Universite des Sciences de la Sante, B P 4009 Libreville, Gabon
    Malar J 9:321. 2010
    ..A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gentil. The aim was to assess the malaria transmission risk for troops...
  101. pmc Pyrethroid resistance in the major malaria vector Anopheles arabiensis from Gwave, a malaria-endemic area in Zimbabwe
    Givemore Munhenga
    Department of Biological Sciences, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe
    Malar J 7:247. 2008
    ..Following the recent detection of DDT resistance in Anopheles arabiensis in Gokwe, Zimbabwe, the underlying resistance mechanisms in this population were studied...

Research Grants42

  1. Environmental Endocrine Disruptors and Human Sperm Chromosomal Abnormalities
    Melissa Perry; Fiscal Year: 2012
    ..This study investigates whether chemicals common in our daily environment can affect male fertility and potential risks for birth defects. ..
  2. IRS insecticides for malaria control and child neurodevelopment in South Africa
    Brenda Eskenazi; Fiscal Year: 2013
    ..This study aims to provide data to evaluate the risk/benefit of different methods of malaria control and for the development of appropriate interventions to reduce exposure to pregnant women and children. ..
  3. Transcriptomics and Population Genetics of Mosquito Resistance to Pyrethroids
    Mariangela Bonizzoni; Fiscal Year: 2013
    ..gambiae mosquitoes from Kenya. This project will significantly enhance the knowledge of the molecular mechanism of insecticide resistance in An. gambiae, and may lead to the development of more reliable resistance monitoring tools. ..
  4. Fetal Exposure to Environmental Toxicants and Child Outcome
    ENRIQUE MAPUA OSTREA; Fiscal Year: 2012
    ....
  5. Characterization of the sodium channel mutations involved in insecticide resistan
    Nannan Liu; Fiscal Year: 2011
    ....
  6. Modeling Developmental Neurotoxicity of Pesticides in Zebrafish
    Lori A White; Fiscal Year: 2010
    ..Development of a zebrafish model of ADHD would allow for high-throughput studies to screen for pesticide toxicity, explore ADHD pathophysiology in addition to screening for therapeutic compounds to treat ADHD. ..
  7. Sustainable Control of Aedes aegypti and epidemic dengue
    Lars Eisen; Fiscal Year: 2013
    ..The approach may also be applicable to other globally important vector borne diseases, such as malaria, filariasis, and Chagas, which are also transmitted principally in the home. ..
  8. Insecticide Resistance in Culex pipiens pallens Mosquitoes
    Changliang Zhu; Fiscal Year: 2013
    ..pipiens mosquitoes. The knowledge from this application will greatly facilitate the development of new resistance diagnostic methods for this important disease vector in China and the world. ..
  9. Prenatal pyrethroid exposure and child mental, motor and behavioral development
    ROBIN MARJORIE WHYATT; Fiscal Year: 2013
    ..However, no prior study has evaluated associations between pyrethroid metabolites in maternal prenatal urine and cognitive, motor or behavioral outcomes in children. ..
  10. Inner City Toxicants, Child Growth and Development
    Mary Wolff; Fiscal Year: 2009
    ..The Center will support two new investigators in children's environmental research. ..
  11. Pyrethroid Resistance in Malaria Mosquito Anopheles sinensis
    Bin Chen; Fiscal Year: 2012
    ..sinensis mosquitoes, and lays an important foundation for developing new resistance diagnostic methods for the most important malaria vector in China. ..
  12. Insecticide Resistance in Anopheles minimus Mosquitoes
    Guiyun Yan; Fiscal Year: 2012
    ..D. student and one postdoc fellow, and strengthen the molecular entomology laboratory in Nanjing Medical University. ..
  13. Mechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHD
    Jason R Richardson; Fiscal Year: 2011
    ..The investigators will then use this information to exploit this novel model to identify molecular targets for therapeutic intervention in ADHD. ..
  14. Molecular mechanisms of action and resistance of sodium channel-targeting insecti
    Boris Zhorov; Fiscal Year: 2013
    ..New knowledge gained from this fundamental research will have significant impact on future development of effective monitoring and management strategies for controlling major human health-threatening arthropod pests. ..
  15. Insecticide resistance in Africa Malaria mosquitoes
    Maureen Coetzee; Fiscal Year: 2004
    ..2. Transfer these technologies to the VCRU and perform limited field trials in order to generate preliminary data that will enable the development of a full R01 application. ..
  16. ACTIONS OF INSECTICIDES ON SODIUM CHANNEL ISOFORMS
    DAVID SODERLUND; Fiscal Year: 2000
    ..Studies with chimeric and mutated isoforms will identify channel domains that determine pyrethroid sensitivity and will contribute to knowledge of structure-function relationships for sodium channels. ..
  17. Validation of biomarkers of prenatal pesticides exposure
    Robin Whyatt; Fiscal Year: 2003
    ....
  18. Glutathione-s-transferase mediated pyrethroid resistance in Culex pipiens s.l.
    Anthony Cornel; Fiscal Year: 2007
    ..These studies will also lead to understanding the mechanism of metabolic resistance to aid in development of novel, next generation insecticides and synergists that may augment pyrethroids. [unreadable] [unreadable] [unreadable]..
  19. Insecticide Resistance:CYP6D1 Regulation and Alleles
    Jeffrey Scott; Fiscal Year: 2005
    ..The ultimate goal of this research is to discover ways to delay the development of monooxygenase-mediated pyrethroid resistance. ..
  20. Insecticide mosaics and sustainability of treated nets
    Edward Walker; Fiscal Year: 2007
    ..Industry partners Vestergaard-Frandsen and Syngenta are directly involved in these efforts, for formulation and evaluation purposes. ..
  21. MECHANISMS OF PYRETHROID INSECTICIDE NEUROTOXICITY
    Thomas Murray; Fiscal Year: 1990
    ..Considered together, these results may have important clinical implications concerning potential neurotoxic sequelae of pyrethroid exposure...
  22. Peer Education in Pregnancy Study
    Victoria Persky; Fiscal Year: 2006
    ..Results of this study will assist in elucidating the etiologic pathway by which asthma develops early in life, as well as assist in the development of effective intervention programs. ..
  23. TOXIC EFFECT OF CHLORINATED AND PYRETHROID PESTICIDES
    Fumio Matsumura; Fiscal Year: 1990
    ..In the case of the latter, various substrate proteins (e.g., synapsin I, light chain myosin, tubulin, etc.) will be examined to see whether some specific phosphorylation steps are being affected by the changes in the protein kinases...
  24. Development of novel resistance management strategies
    Janet Hemingway; Fiscal Year: 2007
    ..abstract_text> ..
  25. Empirical Determination of Sufficiently Similiar Complex Mixtures
    Chris Gennings; Fiscal Year: 2009
    ..The funded project will further develop/characterize a method of determining sufficient similarity in dose-responsiveness for mixtures with many components. ..
  26. Insecticide Action at the Local Anesthetic Receptor
    David M Soderlund; Fiscal Year: 2011
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
  27. Head Louse Resistance and Control of Pediculosis
    John Clark; Fiscal Year: 2008
    ..There is detailed information on the resistance mechanisms for the pyrethrins/pyrethroids and malathion in many pest insects that will allow us to rapidly and efficiently obtain a complete ..
  28. Mode of Action of Insecticides: Electrophysiological
    Toshio Narahashi; Fiscal Year: 2004
    ..This information will significantly contribute to the development of newer therapeutic means of insecticide intoxication of humans and of more effective and safer insecticides. ..
  29. Trihalomethane Pharmacokinetics and Pharmacodynamics
    MATTHEW ROSS; Fiscal Year: 2003
    ..It is also essential to determine if the same metabolic pathways are operative in rodents and humans and if metabolic flux through the different pathways is similar. ..
  30. Community Health Intervention with Yakima Agricultural *
    Matthew Keifer; Fiscal Year: 2006
    ..abstract_text> ..
  31. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  32. Selfish gene and genetic control of vector-borne diseases
    ZACH ADELMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Development of a cell-based method for high-throughput drug screening in malaria
    Liwang Cui; Fiscal Year: 2008
    ..To facilitate antimalarial drug discovery, we propose to develop a highly sensitive, cell-based, one-step luminescent drug screen assay for high throughput screening of large chemical libraries. [unreadable] [unreadable] [unreadable]..
  34. Plasmodium vivax:Proteomic Analysis of Asexual and Sporozoite Stages
    Liwang Cui; Fiscal Year: 2007
    ..Its recent resurgence in prevalence and emergence of drug- resistant parasite strains have raised a great concern for the future control of malaria. [unreadable] [unreadable] [unreadable]..
  35. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ....
  36. RECEPTORS FROM MOSQUITO AEDES AEGYPTI EXCRETORY SYSTEM
    PATRICIA PIETRANTONIO; Fiscal Year: 2002
    ..Aegypti. To test the hypothesis, the applicant proposes to clone the receptor gene, localize the tissue expression by in situ hybridization and immunohistochemistry and express the protein in transformed cells. ..
  37. Forward and Reverse Genetics in Mosquitoes Using an RNA Virus
    ZACH ADELMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. 3rd International Scientific Conference on Occupational and Environmental Health
    Matthew Keifer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. Translational Control in Plasmodium Sexual Development
    Liwang Cui; Fiscal Year: 2005
    ....
  40. CHOLINERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2006
    ....
  41. Anti-larval measures for malaria control in The Gambia
    Steven Lindsay; Fiscal Year: 2007
    ..The results from this study will make a major contribution to quantifying the importance of the use of Bs and Bti in the fight against malaria. ..