salicylic acid

Summary

Summary: A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics. (From Dorland's, 28th ed)

Top Publications

  1. ncbi Role of plant hormones in plant defence responses
    Rajendra Bari
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Plant Mol Biol 69:473-88. 2009
  2. ncbi Systemic acquired resistance
    W E Durrant
    Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Annu Rev Phytopathol 42:185-209. 2004
  3. ncbi Plant stomata function in innate immunity against bacterial invasion
    Maeli Melotto
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Cell 126:969-80. 2006
  4. ncbi Salicylic Acid, a multifaceted hormone to combat disease
    A Corina Vlot
    Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany
    Annu Rev Phytopathol 47:177-206. 2009
  5. pmc Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation
    Xiao yu Zheng
    Department of Biology, Duke University, Durham, NC 27708, USA
    Cell Host Microbe 11:587-96. 2012
  6. ncbi Isochorismate synthase is required to synthesize salicylic acid for plant defence
    M C Wildermuth
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:562-5. 2001
  7. pmc Cross talk in defense signaling
    Annemart Koornneef
    Graduate School Experimental Plant Sciences, Plant Microbe Interactions, Institute of Environmental Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Plant Physiol 146:839-44. 2008
  8. pmc Glucosinolate metabolites required for an Arabidopsis innate immune response
    Nicole K Clay
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 323:95-101. 2009
  9. pmc Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins
    Yasuomi Tada
    Department of Biology, Post Office Box 90338, Duke University, Durham, NC 27708, USA
    Science 321:952-6. 2008
  10. ncbi Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack
    Martin De Vos
    Graduate School Experimental Plant Sciences, Section Phytopathology, Department of Biology, Utrecht Faculty of Science, Utrecht University, P O Box 800 84, 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 18:923-37. 2005

Detail Information

Publications371 found, 100 shown here

  1. ncbi Role of plant hormones in plant defence responses
    Rajendra Bari
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Plant Mol Biol 69:473-88. 2009
    ..Significant progress has been made in identifying the key components and understanding the role of salicylic acid (SA), jasmonates (JA) and ethylene (ET) in plant responses to biotic stresses...
  2. ncbi Systemic acquired resistance
    W E Durrant
    Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Annu Rev Phytopathol 42:185-209. 2004
    ..SAR requires the signal molecule salicylic acid (SA) and is associated with accumulation of pathogenesis-related proteins, which are thought to contribute to ..
  3. ncbi Plant stomata function in innate immunity against bacterial invasion
    Maeli Melotto
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Cell 126:969-80. 2006
    ..We provide evidence that supports a model in which stomata, as part of an integral innate immune system, act as a barrier against bacterial infection...
  4. ncbi Salicylic Acid, a multifaceted hormone to combat disease
    A Corina Vlot
    Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany
    Annu Rev Phytopathol 47:177-206. 2009
    For more than 200 years, the plant hormone salicylic acid (SA) has been studied for its medicinal use in humans...
  5. pmc Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation
    Xiao yu Zheng
    Department of Biology, Duke University, Durham, NC 27708, USA
    Cell Host Microbe 11:587-96. 2012
    ..propagation in both local and systemic tissues by inhibiting the accumulation of the key plant immune signal salicylic acid (SA)...
  6. ncbi Isochorismate synthase is required to synthesize salicylic acid for plant defence
    M C Wildermuth
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:562-5. 2001
    b>Salicylic acid (SA) mediates plant defences against pathogens, accumulating in both infected and distal leaves in response to pathogen attack...
  7. pmc Cross talk in defense signaling
    Annemart Koornneef
    Graduate School Experimental Plant Sciences, Plant Microbe Interactions, Institute of Environmental Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Plant Physiol 146:839-44. 2008
  8. pmc Glucosinolate metabolites required for an Arabidopsis innate immune response
    Nicole K Clay
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 323:95-101. 2009
    ..Our study shows that well-studied plant metabolites, previously identified as important in avoiding damage by herbivores, are also required as a component of the plant defense response against microbial pathogens...
  9. pmc Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins
    Yasuomi Tada
    Department of Biology, Post Office Box 90338, Duke University, Durham, NC 27708, USA
    Science 321:952-6. 2008
    ..In plants, these redox changes regulate the conformation of NPR1, a master regulator of salicylic acid (SA)-mediated defense genes...
  10. ncbi Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack
    Martin De Vos
    Graduate School Experimental Plant Sciences, Section Phytopathology, Department of Biology, Utrecht Faculty of Science, Utrecht University, P O Box 800 84, 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 18:923-37. 2005
    ..against pathogens and insects are regulated differentially by cross-communicating signaling pathways in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play key roles...
  11. pmc The outcomes of concentration-specific interactions between salicylate and jasmonate signaling include synergy, antagonism, and oxidative stress leading to cell death
    Luis A J Mur
    Institute of Biological Science, University of Wales, Aberystwyth, United Kingdom
    Plant Physiol 140:249-62. 2006
    b>Salicylic acid (SA) has been proposed to antagonize jasmonic acid (JA) biosynthesis and signaling...
  12. ncbi Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes
    Zhonglin Mou
    Developmental, Cell, and Molecular Biology Group, Department of Biology, P O Box 91000, Duke University, Durham, NC 27708, USA
    Cell 113:935-44. 2003
    ..SAR induction results in accumulation of the signal molecule salicylic acid (SA), which induces defense gene expression via activation of NPR1...
  13. ncbi Cross talk between signaling pathways in pathogen defense
    Barbara N Kunkel
    Department of Biology, Washington University, Campus Box 1137, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Curr Opin Plant Biol 5:325-31. 2002
    ..attack is regulated through a complex network of signaling pathways that involve three signaling molecules: salicylic acid (SA), jasmonic acid (JA) and ethylene. The SA and JA signaling pathways are mutually antagonistic...
  14. pmc NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants
    Zheng Qing Fu
    Howard Hughes Medical Institute Gordon and Betty Moore Foundation, Department of Biology, PO Box 90338, Duke University, Durham, North Carolina 27708, USA
    Nature 486:228-32. 2012
    b>Salicylic acid (SA) is a plant immune signal produced after pathogen challenge to induce systemic acquired resistance. It is the only major plant hormone for which the receptor has not been firmly identified...
  15. ncbi Priming in systemic plant immunity
    Ho Won Jung
    Department of Molecular Genetics and Cell Biology, University of Chicago, 1103 East 57th Street EBC410, Chicago, IL 60637, USA
    Science 324:89-91. 2009
    ..Azelaic acid primes plants to accumulate salicylic acid (SA), a known defense signal, upon infection...
  16. pmc Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis
    Kohki Yoshimoto
    RIKEN, Plant Science Center, Tsurumi ku, Yokohama, Japan
    Plant Cell 21:2914-27. 2009
    ..Here, we demonstrate a conserved requirement for salicylic acid (SA) signaling for these phenomena in autophagy-defective mutants (atg mutants)...
  17. pmc The WRKY70 transcription factor: a node of convergence for jasmonate-mediated and salicylate-mediated signals in plant defense
    Jing Li
    Department of Biosciences, Division of Genetics, University of Helsinki, FIN 00014 Helsinki, Finland
    Plant Cell 16:319-31. 2004
    Cross talk between salicylic acid (SA)- and jasmonic acid (JA)-dependent defense signaling has been well documented in plants, but how this cross talk is executed and the components involved remain to be elucidated...
  18. ncbi The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid
    Yue Wu
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada L2S 3A1
    Cell Rep 1:639-47. 2012
    b>Salicylic acid (SA) is an essential hormone in plant immunity, but its receptor has remained elusive for decades...
  19. pmc Salicylic acid suppresses jasmonic acid signaling downstream of SCFCOI1-JAZ by targeting GCC promoter motifs via transcription factor ORA59
    Dieuwertje van der Does
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Cell 25:744-61. 2013
    Antagonism between the defense hormones salicylic acid (SA) and jasmonic acid (JA) plays a central role in the modulation of the plant immune signaling network, but the molecular mechanisms underlying this phenomenon are largely unknown...
  20. ncbi AtMYB44 regulates WRKY70 expression and modulates antagonistic interaction between salicylic acid and jasmonic acid signaling
    Jae Sung Shim
    Department of Agricultural Biotechnology, Seoul National University, Seoul, 151 921, Korea
    Plant J 73:483-95. 2013
    The role of AtMYB44, an R2R3 MYB transcription factor, in signaling mediated by jasmonic acid (JA) and salicylic acid (SA) is examined. AtMYB44 is induced by JA through CORONATINE INSENSITIVE 1 (COI1)...
  21. pmc Activation of the indole-3-acetic acid-amido synthetase GH3-8 suppresses expansin expression and promotes salicylate- and jasmonate-independent basal immunity in rice
    Xinhua Ding
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Cell 20:228-40. 2008
    ..GH3-8, an auxin-responsive gene functioning in auxin-dependent development, activates disease resistance in a salicylic acid signaling- and jasmonic acid signaling-independent pathway...
  22. pmc Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7
    Michael Bartsch
    Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, D 50829 Cologne, Germany
    Plant Cell 18:1038-51. 2006
    ..interacting partner, PHYTOALEXIN-DEFICIENT4 (PAD4), regulates accumulation of the phenolic defense molecule salicylic acid (SA) and other as yet unidentified signal intermediates...
  23. ncbi Interplay between MAMP-triggered and SA-mediated defense responses
    Kenichi Tsuda
    Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St Paul, MN 55108, USA
    Plant J 53:763-75. 2008
    ..b>Salicylic acid (SA)-mediated responses are an important part of the R gene-mediated defense...
  24. pmc Silverleaf whitefly induces salicylic acid defenses and suppresses effectual jasmonic acid defenses
    Sonia I Zarate
    Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, California 92521 0124, USA
    Plant Physiol 143:866-75. 2007
    ..Sentinel defense gene RNAs were monitored in SLWF-infested and control plants. Salicylic acid (SA)-responsive gene transcripts accumulated locally (PR1, BGL2, PR5, SID2, EDS5, PAD4) and systemically (PR1, ..
  25. pmc Ethylene biosynthesis and signaling networks
    Kevin L C Wang
    Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Plant Cell 14:S131-51. 2002
  26. pmc A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants
    Sruti DebRoy
    Cell and Molecular Biology Program and Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 101:9927-32. 2004
    b>Salicylic acid (SA)-mediated host immunity plays a central role in combating microbial pathogens in plants. Inactivation of SA-mediated immunity, therefore, would be a critical step in the evolution of a successful plant pathogen...
  27. ncbi NPR1, all things considered
    Xinnian Dong
    Developmental, Cell and Molecular Biology Group, LSRC Building, Research Drive, Duke University, Durham, North Carolina 27708 1000, USA
    Curr Opin Plant Biol 7:547-52. 2004
    Recent work has shown that the Arabidopsis NPR1 protein not only plays an essential role in salicylic acid (SA)-mediated systemic acquired resistance and rhizobacterium-triggered induced systemic resistance, but also is involved in ..
  28. ncbi Induction of protein secretory pathway is required for systemic acquired resistance
    Dong Wang
    Developmental, Cell and Molecular Biology Group, Department of Biology, Post Office Box 91000, Duke University, Durham, NC 27708, USA
    Science 308:1036-40. 2005
    ..Activation of this cis-element is controlled by a transcription factor that is translocated into the nucleus upon SAR induction...
  29. ncbi Salicylic acid antagonism of EDS1-driven cell death is important for immune and oxidative stress responses in Arabidopsis
    Marco R Straus
    Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, 50829 Köln, Germany
    Plant J 62:628-40. 2010
    ..nudt7) mutants are sensitized to photo-oxidative stress and display EDS1-dependent enhanced resistance, salicylic acid (SA) accumulation and initiation of cell death...
  30. pmc Cytokinins mediate resistance against Pseudomonas syringae in tobacco through increased antimicrobial phytoalexin synthesis independent of salicylic acid signaling
    Dominik K Grosskinsky
    Institute for Plant Sciences, Department of Plant Physiology, University of Graz, 8010 Graz, Austria
    Plant Physiol 157:815-30. 2011
    ..syringae. In contrast to a cytokinin defense mechanism in Arabidopsis (Arabidopsis thaliana) based on salicylic acid-dependent transcriptional control, the cytokinin-mediated resistance in tobacco is essentially independent ..
  31. pmc Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross talk between salicylate and jasmonate signaling
    Antonio Leon-Reyes
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Physiol 149:1797-809. 2009
    The plant hormones salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play crucial roles in the signaling network that regulates induced defense responses against biotic stresses...
  32. ncbi Hormone (dis)harmony moulds plant health and disease
    Murray R Grant
    School of Biosciences, University of Exeter, Exeter EX4 4QD, UK
    Science 324:750-2. 2009
    ..A better understanding of cross-talk between hormonal and defense signaling pathways should reveal new potential targets for microbial effectors that attenuate host resistance mechanisms...
  33. pmc Rice WRKY45 plays a crucial role in benzothiadiazole-inducible blast resistance
    Masaki Shimono
    Plant Disease Resistance Research Unit, National Institute of Agrobiological Sciences, Ibaraki, Japan
    Plant Cell 19:2064-76. 2007
    Benzothiadiazole (BTH) is a so-called plant activator and protects plants from diseases by activating the salicylic acid (SA) signaling pathway...
  34. pmc Kinetics of salicylate-mediated suppression of jasmonate signaling reveal a role for redox modulation
    Annemart Koornneef
    Graduate School Experimental Plant Sciences, Institute of Environmental Biology, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Physiol 147:1358-68. 2008
    Cross talk between salicylic acid (SA) and jasmonic acid (JA) signaling pathways plays an important role in the regulation and fine tuning of induced defenses that are activated upon pathogen or insect attack...
  35. ncbi The cytokinin-activated transcription factor ARR2 promotes plant immunity via TGA3/NPR1-dependent salicylic acid signaling in Arabidopsis
    Jaemyung Choi
    Department of Life Sciences, Pohang University of Science and Technology, Korea
    Dev Cell 19:284-95. 2010
    ..In fact, the cytokinin-activated transcription factor ARR2 contributes specifically to Pst resistance. The salicylic acid (SA) response factor TGA3 binds ARR2, and mutation of TGA-binding cis-elements in the Pr1 promoter abolished ..
  36. ncbi The Arabidopsis thaliana JASMONATE INSENSITIVE 1 gene is required for suppression of salicylic acid-dependent defenses during infection by Pseudomonas syringae
    Neva Laurie-Berry
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Mol Plant Microbe Interact 19:789-800. 2006
    ..is correlated with elevated expression of pathogenesis-related 1 (PR-1) and is dependent on accumulation of salicylic acid (SA). We also show that JIN1 is required for normal P. syringae pv...
  37. ncbi Plant growth-promoting rhizobacteria systemically protect Arabidopsis thaliana against Cucumber mosaic virus by a salicylic acid and NPR1-independent and jasmonic acid-dependent signaling pathway
    Choong Min Ryu
    Department of Entomology and Plant Pathology, Auburn University, AL 36849, USA
    Plant J 39:381-92. 2004
    ..with strains 90-166 and SE34 had reduced symptom severity indicating that the resistance did not require salicylic acid (SA). Strain 90-166 naturally produces SA under iron-limited conditions...
  38. pmc Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1
    Jin Long Qiu
    Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark
    Plant Physiol 148:212-22. 2008
    ..In addition, transcriptome analyses delineate overlapping and specific effects of the kinases on global gene expression patterns demonstrating both redundant and unique functions for MKK1 and MKK2...
  39. pmc A gain-of-function mutation in an Arabidopsis Toll Interleukin1 receptor-nucleotide binding site-leucine-rich repeat type R gene triggers defense responses and results in enhanced disease resistance
    Yumiko Shirano
    Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA
    Plant Cell 14:3149-62. 2002
    In a screen for suppressors of npr1-5-based salicylic acid (SA) insensitivity, we isolated a semidominant gain-of-function mutation, designated ssi4, that confers constitutive expression of several PR (pathogenesis-related) genes, induces ..
  40. pmc Antagonistic interaction between systemic acquired resistance and the abscisic acid-mediated abiotic stress response in Arabidopsis
    Michiko Yasuda
    Plant Acquired Immunity Research Unit, Advanced Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Plant Cell 20:1678-92. 2008
    ..in dicotyledonous plants, such as tobacco (Nicotiana tabacum) and Arabidopsis thaliana, is mediated by salicylic acid (SA)...
  41. ncbi Expression profiling and mutant analysis reveals complex regulatory networks involved in Arabidopsis response to Botrytis infection
    Synan Abuqamar
    Department of Botany and Plant Pathology, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Plant J 48:28-44. 2006
    ..for jasmonate signaling, whereas the expression of 63 and 80 BIGs were dependent on ethylene (ET) signaling or salicylic acid accumulation, respectively, based on results from ein2 and nahG plants...
  42. ncbi Towards global understanding of plant defence against aphids--timing and dynamics of early Arabidopsis defence responses to cabbage aphid (Brevicoryne brassicae) attack
    Anna Kusnierczyk
    Department of Biology, The Norwegian University of Science and Technology, Realfagbygget, 7491 Trondheim, Norway
    Plant Cell Environ 31:1097-115. 2008
    ..Data indicated the involvement of reactive oxygen species (ROS) and calcium in early signalling, and salicylic acid (SA) and jasmonic acid (JA) in the regulation of defence responses...
  43. ncbi Salicylic acid inhibits pathogen growth in plants through repression of the auxin signaling pathway
    Dong Wang
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Curr Biol 17:1784-90. 2007
    ..Plants overaccumulating the defense signal molecule salicylic acid (SA) frequently display morphological phenotypes that are reminiscent of auxin-deficient or auxin-insensitive ..
  44. ncbi Ca(2+)/calmodulin regulates salicylic-acid-mediated plant immunity
    Liqun Du
    Center for Integrated Biotechnology and Department of Horticulture, Washington State University, Pullman, Washington 99164 6414, USA
    Nature 457:1154-8. 2009
    ..b>Salicylic acid, a critical messenger, is also required for both of these responses, but whether and how salicylic acid level ..
  45. ncbi Loss of a callose synthase results in salicylic acid-dependent disease resistance
    Marc T Nishimura
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA
    Science 301:969-72. 2003
    ..Double-mutant analysis indicated that blocking the salicylic acid (SA) defense signaling pathway was sufficient to restore susceptibility to pmr4 mutants...
  46. ncbi Salicylic acid beyond defence: its role in plant growth and development
    Mariana Rivas-San Vicente
    Departamento de Bioquimica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Av Universidad y Copilco, 04510, Mexico, DF, Mexico
    J Exp Bot 62:3321-38. 2011
    In recent years salicylic acid (SA) has been the focus of intensive research due to its function as an endogenous signal mediating local and systemic plant defence responses against pathogens...
  47. ncbi The phytotoxin coronatine contributes to pathogen fitness and is required for suppression of salicylic acid accumulation in tomato inoculated with Pseudomonas syringae pv. tomato DC3000
    Srinivasa Rao Uppalapati
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater 74078, USA
    Mol Plant Microbe Interact 20:955-65. 2007
    The roles of the phytotoxin coronatine (COR) and salicylic acid (SA)-mediated defenses in the interaction of Pseudomonas syringae pv. tomato DC3000 and tomato (Solanum lycopersicum) were investigated...
  48. ncbi Fusarium oxysporum hijacks COI1-mediated jasmonate signaling to promote disease development in Arabidopsis
    Louise F Thatcher
    CSIRO Plant Industry, Queensland Bioscience Precinct, St Lucia, QLD 4067, Australia
    Plant J 58:927-39. 2009
    ..oxysporum. This response was independent from salicylic acid-dependent defenses, as coi1/NahG plants showed similar disease resistance to coi1 plants...
  49. ncbi Salicylic acid and its function in plant immunity
    Chuanfu An
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA
    J Integr Plant Biol 53:412-28. 2011
    The small phenolic compound salicylic acid (SA) plays an important regulatory role in multiple physiological processes including plant immune response...
  50. pmc The membrane-anchored BOTRYTIS-INDUCED KINASE1 plays distinct roles in Arabidopsis resistance to necrotrophic and biotrophic pathogens
    Paola Veronese
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907 2054, USA
    Plant Cell 18:257-73. 2006
    ..Whereas the pathogen responses of bik1 are mostly dependent on salicylic acid (SA) levels, the nondefense responses are independent of SA...
  51. ncbi OsWRKY13 mediates rice disease resistance by regulating defense-related genes in salicylate- and jasmonate-dependent signaling
    Deyun Qiu
    National Key Laboratory of Crop Genetic Improvement, National Center for Plant Gene Research, Huazhong Agricultural University, Wuhan 430070, China
    Mol Plant Microbe Interact 20:492-9. 2007
    ..This overexpression was accompanied by the activation of salicylic acid (SA) synthesis-related genes and SA-responsive genes and the suppression of jasmonic acid (JA) synthesis-..
  52. pmc NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol
    Steven H Spoel
    Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Plant Cell 15:760-70. 2003
    ..and insects are regulated differentially by cross-communicating signal transduction pathways in which salicylic acid (SA) and jasmonic acid (JA) play key roles...
  53. pmc Evidence for an important role of WRKY DNA binding proteins in the regulation of NPR1 gene expression
    D Yu
    Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 83844-3052, USA
    Plant Cell 13:1527-40. 2001
    ..Expression of NPR1 is induced by pathogen infection or treatment with defense-inducing compounds such as salicylic acid (SA)...
  54. pmc Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene
    Y Zhang
    Developmental, Cell, and Molecular Biology Group, Department of Botany, Box 91000, Duke University, Durham, NC 27708 1000, USA
    Proc Natl Acad Sci U S A 96:6523-8. 1999
    ..The npr1 mutant plants fail to respond to systemic acquired resistance-inducing signals such as salicylic acid (SA), or express SA-induced pathogenesis-related (PR) genes...
  55. ncbi The salicylic acid loop in plant defense
    Jyoti Shah
    Division of Biology, and the Molecular, Cellular and Developmental Biology Program, 303 Ackert Hall, Kansas State University, 66506 4901, Manhattan, Kansas, USA
    Curr Opin Plant Biol 6:365-71. 2003
    b>Salicylic acid is an important signal molecule in plant defense. In the past two years, significant progress has been made in understanding the mechanism of salicylic-acid biosynthesis and signaling in plants...
  56. pmc A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants
    Paula Hauck
    Department of Energy Plant Research Laboratory and Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 100:8577-82. 2003
    ..the expression of a set of Arabidopsis genes encoding putatively secreted cell wall and defense proteins in a salicylic acid-independent manner...
  57. ncbi MYB96-mediated abscisic acid signals induce pathogen resistance response by promoting salicylic acid biosynthesis in Arabidopsis
    Pil Joon Seo
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    New Phytol 186:471-83. 2010
    ..Here, we investigate the role of MYB96 in salicylic acid (SA) biosynthesis and plant defense and explore the mechanisms underlying the ABA-SA interaction...
  58. ncbi Expression profiles of the Arabidopsis WRKY gene superfamily during plant defense response
    Jixin Dong
    Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, ID 83844 3052, USA
    Plant Mol Biol 51:21-37. 2003
    ..sequences as probes, we detected a number of WRKY DNA-binding activities in Arabidopsis that were induced by salicylic acid (SA)...
  59. pmc Cauliflower mosaic virus protein P6 inhibits signaling responses to salicylic acid and regulates innate immunity
    Andrew J Love
    Plant Science Research Theme, School of Life Sciences and Institute of Molecular, Cellular and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
    PLoS ONE 7:e47535. 2012
    ..additionally acts as a pathogenicity effector of an unique and novel type, modifying NPR1 (a key regulator of salicylic acid (SA)- and jasmonic acid (JA)-dependent signaling) and inhibiting SA-dependent defence responses We find that ..
  60. ncbi Effects of jasmonic acid, ethylene, and salicylic acid signaling on the rhizosphere bacterial community of Arabidopsis thaliana
    Rogier F Doornbos
    Plant Microbe Interactions, Institute of Environmental Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Mol Plant Microbe Interact 24:395-407. 2011
    ..Additionally, ISR was induced by application of methyl jasmonate and SAR by treatment with salicylic acid or benzothiadiazole. As a comparative model, we also used wild type and ethylene-insensitive tobacco...
  61. ncbi Salicylic acid and jasmonic acid signaling defense pathways reduce natural bacterial diversity on Arabidopsis thaliana
    Joel M Kniskern
    Department of Ecology and Evolution, University of Chicago, 60637, USA
    Mol Plant Microbe Interact 20:1512-22. 2007
    ..thaliana mutants deficient in salicylic acid (SA) and jasmonic acid (JA) signaling defense pathways, controls, and plants with artificially elevated levels ..
  62. pmc Genetic dissection of salicylic acid-mediated defense signaling networks in Arabidopsis
    Gina Ng
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Genetics 189:851-9. 2011
    ..One hub of the defense networks is centered on salicylic acid (SA), which plays a key role in activating disease resistance in plants...
  63. pmc Abscisic acid determines basal susceptibility of tomato to Botrytis cinerea and suppresses salicylic acid-dependent signaling mechanisms
    Kris Audenaert
    Laboratory of Phytopathology, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links, 653, B 9000 Gent, Belgium
    Plant Physiol 128:491-501. 2002
    ..transgenic NahG tomato plants and benzo(1,2,3)thiadiazole-7-carbothioic acid demonstrated the importance of salicylic acid in the tomato-B. cinerea interaction. In addition, upon infection with B...
  64. ncbi Antagonism between salicylic and abscisic acid reflects early host-pathogen conflict and moulds plant defence responses
    Marta de Torres Zabala
    School of Biosciences, University of Exeter, Exeter, UK
    Plant J 59:375-86. 2009
    ..In this study, we examined the dynamics, inter-relationship and impact of three key acidic phytohormones, salicylic acid, abscisic acid and jasmonic acid, and the bacterial virulence factor, coronatine, during progression of P...
  65. pmc S-Nitrosoglutathione is a component of wound- and salicylic acid-induced systemic responses in Arabidopsis thaliana
    M Carme Espunya
    Departament de Bioquimica i Biologia Molecular, Facultat de Biociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Exp Bot 63:3219-27. 2012
    ..extending previous work on the role of GSNOR in pathogenesis, it was shown that GSNO acts synergistically with salicylic acid in systemic acquired resistance activation...
  66. pmc Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)
    Xian Zhang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA
    J Med Chem 53:2482-93. 2010
    ..We report a salicylic acid based combinatorial library approach aimed at binding both active site and unique nearby subpockets for ..
  67. ncbi NONEXPRESSOR OF PATHOGENESIS-RELATED PROTEINS1 (NPR1) and some NPR1-related proteins are sensitive to salicylic acid
    Felix Maier
    Institut fur Genetik, Universitat Hohenheim, FG Allgemeine Virologie, D 70593 Stuttgart, Germany
    Mol Plant Pathol 12:73-91. 2011
    ..SAR is induced by salicylic acid (SA), leading to the expression of PATHOGENESIS-RELATED (PR) genes...
  68. ncbi Absolute protein quantification by LC/MS(E) for global analysis of salicylic acid-induced plant protein secretion responses
    Fang yi Cheng
    Department of Horticultural Science, North Carolina State University, Raleigh, North Carolina 27695 7609, USA
    J Proteome Res 8:82-93. 2009
    ..wall proteome in response to different levels of an endogenous inducer of plant disease defense responses, salicylic acid (SA)...
  69. pmc Brassinosteroid-mediated stress tolerance in Arabidopsis shows interactions with abscisic acid, ethylene and salicylic acid pathways
    Uday K Divi
    Department of Biology, University of Western Ontario, London, ON N6A5B7, Canada
    BMC Plant Biol 10:151. 2010
    ..Since BR interacts with other plant hormones, it is likely that the stress tolerance conferring ability of BR lies in part in its interactions with other stress hormones...
  70. ncbi Interplay of signaling pathways in plant disease resistance
    B J Feys
    Sainsbury Laboratory, John Innes Centre, Colney Lane, NR4 7UH, Norwich, UK
    Trends Genet 16:449-55. 2000
    ..The interplay of signals probably allows the plant to fine-tune defense responses in both local and systemic tissue...
  71. pmc Salicylic acid mediates the reduced growth of lignin down-regulated plants
    Lina Gallego-Giraldo
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, OK 73401, USA
    Proc Natl Acad Sci U S A 108:20814-9. 2011
    ..Levels of the stress hormone salicylic acid (SA) are inversely proportional to lignin levels and growth in a series of transgenic alfalfa plants in which ..
  72. ncbi Functional analysis of rice NPR1-like genes reveals that OsNPR1/NH1 is the rice orthologue conferring disease resistance with enhanced herbivore susceptibility
    Yuexing Yuan
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Plant Biotechnol J 5:313-24. 2007
    The key regulator of salicylic acid (SA)-mediated resistance, NPR1, is functionally conserved in diverse plant species, including rice (Oryza sativa L.)...
  73. pmc A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants
    Dong Wang
    Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina, United States of America
    PLoS Pathog 2:e123. 2006
    ..SAR) is an inducible plant defense response involving a cascade of transcriptional events induced by salicylic acid through the transcription cofactor NPR1...
  74. pmc Protection against heat stress-induced oxidative damage in Arabidopsis involves calcium, abscisic acid, ethylene, and salicylic acid
    Jane Larkindale
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
    Plant Physiol 128:682-95. 2002
    ..We examined specifically the involvement of calcium, abscisic acid (ABA), ethylene, and salicylic acid (SA) in the protection against heat-induced oxidative damage in Arabidopsis...
  75. pmc Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4
    B J Feys
    The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK
    EMBO J 20:5400-11. 2001
    ..response, whereas EDS1 and PAD4 are both required for accumulation of the plant defence-potentiating molecule, salicylic acid. EDS1 is necessary for pathogen-induced PAD4 mRNA accumulation, whereas mutations in PAD4 or depletion of ..
  76. ncbi Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4
    Peter Brodersen
    Institute of Molecular Biology, Copenhagen University, Øster Farimagsgade 2A, DK 1353 Copenhagen K, Denmark
    Plant J 47:532-46. 2006
    ..been implicated in plant defense regulation because mpk4 knockout plants exhibit constitutive activation of salicylic acid (SA)-dependent defenses, but fail to induce jasmonic acid (JA) defense marker genes in response to JA...
  77. pmc Whiteflies interfere with indirect plant defense against spider mites in Lima bean
    Peng Jun Zhang
    Laboratory of Entomology, Wageningen University, PO Box 8031, 6700 EH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 106:21202-7. 2009
    ..When using exogenous salicylic acid (SA) application to mimic B...
  78. pmc The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid-mediated floral promotion pathway and through affects on FLC chromatin structure
    Jing Bo Jin
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 2010, USA
    Plant J 53:530-40. 2008
    Loss-of-function siz1 mutations caused early flowering under short days. siz1 plants have elevated salicylic acid (SA) levels, which are restored to wild-type levels by expressing nahG, bacterial salicylate hydroxylase...
  79. pmc A pair of allelic WRKY genes play opposite roles in rice-bacteria interactions
    Zeng Tao
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Physiol 151:936-48. 2009
    ..grisea. OsWRKY45-1-regulated Xoo resistance was accompanied by increased accumulation of salicylic acid and jasmonic acid and induced expression of a subset of defense-responsive genes, while OsWRKY45-2-regulated ..
  80. pmc Transcriptional regulation of sorghum defense determinants against a phloem-feeding aphid
    Keyan Zhu-Salzman
    Department of Entomology, Texas A and M University, College Station, Texas 77843, USA
    Plant Physiol 134:420-31. 2004
    ..greenbug aphid (Schizaphis graminum), sorghum (Sorghum bicolor) activates jasmonic acid (JA)- and salicylic acid (SA)-regulated genes, as well as genes outside known wounding and SA signaling pathways...
  81. pmc Membrane-bound guaiacol peroxidases from maize (Zea mays L.) roots are regulated by methyl jasmonate, salicylic acid, and pathogen elicitors
    Angela Mika
    University of Hamburg, Biocenter Klein Flottbek and Botanical Garden, Plant Physiology, Ohnhorststrasse 18, D 22609 Hamburg, Germany
    J Exp Bot 61:831-41. 2010
    ..down-regulated by wounding, all four enzymes were differentially but strongly stimulated by methyl jasmonate, salicylic acid, and elicitors (Fusarium graminearum and Fusarium culmorum extracts, and chitosan) indicating their function ..
  82. ncbi Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, identified in a selective screen utilizing the SA-inducible expression of the tms2 gene
    J Shah
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855, USA
    Mol Plant Microbe Interact 10:69-78. 1997
    b>Salicylic acid (SA) plays an important signaling role in the resistance of many plants to pathogen invasion...
  83. ncbi Heterotrimeric G proteins-mediated resistance to necrotrophic pathogens includes mechanisms independent of salicylic acid-, jasmonic acid/ethylene- and abscisic acid-mediated defense signaling
    Yuri Trusov
    School of Integrative Biology, University of Queensland, St Lucia, Queensland, 4072, Australia
    Plant J 58:69-81. 2009
    ..Gβ-mediated signaling suppresses the induction of salicylic acid (SA)-, jasmonic acid (JA)-, ethylene (ET)- and abscisic acid (ABA)-dependent genes during the initial phase of ..
  84. ncbi CBP60g and SARD1 play partially redundant critical roles in salicylic acid signaling
    Lin Wang
    Department of Plant Biology and Microbial and Plant Genomics Institute, University of Minnesota, 1445 Gortner Avenue, St Paul, MN 55108, USA
    Plant J 67:1029-41. 2011
    Arabidopsis thaliana calmodulin binding protein 60g (CBP60g) contributes to production of salicylic acid (SA) in response to recognition of microbe-associated molecular patterns (MAMPs) such as flg22, a fragment of bacterial flagellin...
  85. pmc Amino acid homeostasis modulates salicylic acid-associated redox status and defense responses in Arabidopsis
    Guosheng Liu
    Department of Biology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E2, Canada
    Plant Cell 22:3845-63. 2010
    ..LHT1), is sufficient for Arabidopsis thaliana plants to confer a broad spectrum of disease resistance in a salicylic acid-dependent manner...
  86. pmc Control of salicylic acid synthesis and systemic acquired resistance by two members of a plant-specific family of transcription factors
    Yaxi Zhang
    National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing 102206, China
    Proc Natl Acad Sci U S A 107:18220-5. 2010
    b>Salicylic acid (SA) is a defense hormone required for both local and systemic acquired resistance (SAR) in plants...
  87. ncbi Resistant and susceptible responses in tomato to cyst nematode are differentially regulated by salicylic acid
    Taketo Uehara
    National Agricultural Research Center for Hokkaido Region, 1 Hitsujigaoka, Toyohira ku, Sapporo 062 8555, Japan
    Plant Cell Physiol 51:1524-36. 2010
    ..PR) protein genes in tomato roots were compared between the incompatible and compatible interactions, the salicylic acid (SA)-dependent PR genes were found to be induced in the incompatible interaction at 3 dpi...
  88. pmc Disruption of the vacuolar calcium-ATPases in Arabidopsis results in the activation of a salicylic acid-dependent programmed cell death pathway
    Yann Boursiac
    Biochemistry Department, University of Nevada, Reno, Nevada 89557, USA
    Plant Physiol 154:1158-71. 2010
    ..Initiation and spread of lesions could also be suppressed by disrupting the production or accumulation of salicylic acid (SA), as shown by combining aca4/11 mutations with a sid 2 (for salicylic acid induction-deficient2) mutation ..
  89. pmc Involvement of salicylate and jasmonate signaling pathways in Arabidopsis interaction with Fusarium graminearum
    Ragiba Makandar
    Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA
    Mol Plant Microbe Interact 23:861-70. 2010
    ..that constitutively overexpress the NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) gene, which regulates salicylic acid (SA) signaling and modulates the activation of jasmonic acid (JA)-dependent defenses...
  90. ncbi Signaling pathways controlling induced resistance to insect herbivores in Arabidopsis
    Natacha Bodenhausen
    Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland
    Mol Plant Microbe Interact 20:1406-20. 2007
    ..The implication of ethylene (ET), salicylic acid (SA), and other signals in this response is less understood and was monitored with a microarray containing ..
  91. pmc The synthetic elicitor 3,5-dichloroanthranilic acid induces NPR1-dependent and NPR1-independent mechanisms of disease resistance in Arabidopsis
    Colleen Knoth
    Center for Plant Cell Biology, Institute for Integrative Genome Biology, Department of Botany and Plant Sciences, University of California at Riverside, Riverside, California 92521, USA
    Plant Physiol 150:333-47. 2009
    ..parasitica and Pseudomonas syringae. In contrast to known salicylic acid analogs, such as 2,6-dichloroisonicotinic acid (INA), which exhibit a long-lasting defense-inducing activity ..
  92. pmc Roles of salicylic acid, jasmonic acid, and ethylene in cpr-induced resistance in arabidopsis
    J D Clarke
    Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Plant Cell 12:2175-90. 2000
    Disease resistance in Arabidopsis is regulated by multiple signal transduction pathways in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) function as key signaling molecules...
  93. ncbi ABA hypersensitive germination2-1 causes the activation of both abscisic acid and salicylic acid responses in Arabidopsis
    Noriyuki Nishimura
    Graduate School of Art and Science, Yokohama City University, 1 7 29 Suehiro, Tsurumi, Yokohama, 230 0045, Japan
    Plant Cell Physiol 50:2112-22. 2009
    ABA and salicylic acid (SA) are believed to act antagonistically...
  94. pmc Salicylate accumulation inhibits growth at chilling temperature in Arabidopsis
    Ian M Scott
    Institute of Biological Sciences, University of Wales, Aberystwyth, SY23 3DA, United Kingdom
    Plant Physiol 135:1040-9. 2004
    The growth of Arabidopsis plants in chilling conditions could be related to their levels of salicylic acid (SA)...
  95. ncbi Insect eggs suppress plant defence against chewing herbivores
    Friederike Bruessow
    Department of Plant Molecular Biology, University of Lausanne, CH 1015 Lausanne, Switzerland
    Plant J 62:876-85. 2010
    ..In the present study, we found that the plant defence signal salicylic acid (SA) accumulates at the site of oviposition...
  96. ncbi DELLAs control plant immune responses by modulating the balance of jasmonic acid and salicylic acid signaling
    Lionel Navarro
    The Sainsbury Laboratory, John Innes Centre, Norwich, UK
    Curr Biol 18:650-5. 2008
    ..to virulent biotrophs and resistance to necrotrophs, partly by altering the relative strength of salicylic acid and jasmonic acid (JA) signaling...
  97. ncbi Early genomic responses to salicylic acid in Arabidopsis
    Francisca Blanco
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Plant Mol Biol 70:79-102. 2009
    b>Salicylic acid (SA) is a stress-induced hormone involved in the activation of defense genes...
  98. ncbi Virulence systems of Pseudomonas syringae pv. tomato promote bacterial speck disease in tomato by targeting the jasmonate signaling pathway
    Youfu Zhao
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Plant J 36:485-99. 2003
    ....
  99. pmc Novel plant immune-priming compounds identified via high-throughput chemical screening target salicylic acid glucosyltransferases in Arabidopsis
    Yoshiteru Noutoshi
    Research Core for Interdisciplinary Sciences, Okayama University, Kita ku, Okayama 700 8530, Japan
    Plant Cell 24:3795-804. 2012
    Plant activators are compounds, such as analogs of the defense hormone salicylic acid (SA), that protect plants from pathogens by activating the plant immune system...
  100. pmc The pepper E3 ubiquitin ligase RING1 gene, CaRING1, is required for cell death and the salicylic acid-dependent defense response
    Dong Hyuk Lee
    Laboratory of Molecular Plant Pathology, School of Life Sciences and Biotechnology, Korea University, Seoul 136 713, Republic of Korea
    Plant Physiol 156:2011-25. 2011
    ..accompanied by compromised hypersensitive cell death, reduced expression of PATHOGENESIS-RELATED1, and lowered salicylic acid levels in leaves...
  101. ncbi Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity
    Guilherme A Spitz
    Laboratório de Oncobiologia Molecular LabOMol, Departamento de Fármacos, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941 590, RJ, Brazil
    Biochem Pharmacol 77:46-53. 2009
    ..Anti-inflammatory drugs, such as acetylsalicylic acid (ASA) and salicylic acid (SA), present anti-tumoral properties, inducing apoptosis and altering tumor glucose utilization...

Research Grants36

  1. Novel mechanisms by which aspirin might protect against atherosclerosis
    Sampath Parthasarathy; Fiscal Year: 2012
    ..We recently observed that aspirin is hydrolyzed to salicylic acid, a potent antioxidant and a hydroxyl radical trapping agent, by human plasma and HDL subfraction...
  2. Stomate-based innate immunity against bacterial infection in Arabidopsis
    Maeli Melotto; Fiscal Year: 2012
    ..requires a flagellin receptor as well as production and signaling of the plant hormones abscisic acid and salicylic acid. The virulent plant pathogen Pst DC3000 produces the phytotoxin coronatine (COR) to suppress stomatal closure ..
  3. Small Molecule Inhibitors for the Oncogenic Protein Tyrosine Phosphatase SHP2
    Zhong Yin Zhang; Fiscal Year: 2013
    ..to overcome the bioavailability issue, we have developed a breakthrough chemistry platform based on bicyclic salicylic acid pharmacophores that are sufficiently polar to bind the PTP active site, yet remain capable of efficiently ..
  4. Dynamic regulation of salicylic acid biosynthesis &perception in plant immunity
    Xinnian Dong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salicylic acid (SA) and derivatives, such as aspirin, have a long list of medicinal effects, which include not only fever reduction and pain relief, but also prevention of cardiovascular diseases and ..
  5. GENETIC ANALYSIS OF THE PLANT DEFENSE RESPONSE
    Frederick M Ausubel; Fiscal Year: 2013
    ..round of MERIT funding: We will investigate how MAMP-activated pathways relate to defense pathways mediated by salicylic acid, JA and ET. We will determine the molecular mechanism by which coronatine blocks MAMP signaling...
  6. Metatranscriptomic analysis of the root microbiome
    NATALIE WYNN BREAKFIELD; Fiscal Year: 2013
    ..by wild type roots and the community assembled by cpr5, a mutant plant that over-produces the defense hormone Salicylic Acid (SA)...
  7. Mechanism-Based Biomarkers for Glucose-Lowering in TINSAL-T2D
    Steven E Shoelson; Fiscal Year: 2010
    ..Rationale. We have found that salicylic acid (SA), the active form of salsalate, simultaneously inhibits NF-:B and activates HSF-1 in cultured cells, ..
  8. Local Modulation of Inflammation to Heal Cranial-facial Bone Defects
    KATHRYN ELIZABETH UHRICH; Fiscal Year: 2012
    ..We will use a poly (anhydride-ester) of salicylic acid (PolyAspirin) to inhibit cyclooxygenase and a 5-lipoxygenase inhibitor within a calcium sulfate carrier and ..
  9. Study of chloroplast stromules during PCD and inter-organellar communication
    Savithramma P Dinesh-Kumar; Fiscal Year: 2013
    ..of stromules during the generation and propagation of pro-cell death signals, such as hydrogen peroxide and salicylic acid, during HR-PCD will be revealed...
  10. Salicylic acid-based small-molecule Stat3 inhibitors for anticancer therapy
    JAMES K TURKSON; Fiscal Year: 2013
    ....
  11. MOLECULAR MECHANISMS OF ASPIRIN IN CANCER PREVENTION
    Zigang Dong; Fiscal Year: 2001
    ..is involved in the inhibiition of tumor promoter-induced AP-1 activity and cell transformation by aspirin or salicylic acid; Aim 3 - To determine whether inhibition of AP-1 acitivity and transformation of aspirin is through a mitogen- ..
  12. POLYMERS WITH BIOACTIVE DEGRADATION PRODUCTS
    Kathryn Uhrich; Fiscal Year: 2000
    ..Replacing the ether bond with an ester bond yields a polymer that degrades into salicylic acid (SA), an anti-inflammatory, antipyretic and analgesic agent...
  13. Novel Topical Treatment for Disorders of Keratinization
    Bakul Bhatt; Fiscal Year: 2005
    ..Current treatment options include the use of emollients and moisturizers, and keratolytic agents including salicylic acid, urea, or alpha hydroxy acids...
  14. Aspirin, UGT1A6 Genotype, and Colon Gene Expression
    Johanna Lampe; Fiscal Year: 2006
    ..Aspirin and its metabolite, salicylic acid, can inhibit growth through the inhibition of cyclooxygenases (catalysts of prostaglandin synthesis), the ..
  15. ENHANCING BRAIN UPTAKE OF AZT BY TRANSPORT INHIBITION
    Ronald Sawchuk; Fiscal Year: 1991
    ..This proposal will examine the effect of probenecid and salicylic acid on the renal secretion of AZT and on the distribution of AZT into CSF and brain tissue in the rabbit...
  16. GENETIC ANALYSIS OF THE PLANT DEFENSE RESPONSE
    FREDERICK AUSUBEL; Fiscal Year: 2004
    ..used to define a variety of defense response pathways that involve the low molecular mass signaling molecules salicylic acid (SA), jasmonic acid (JA) and ethylene (ET)...
  17. RAPID DETECTION OF PRE-AND NEONATAL METABOLIC DISORDERS
    EUGENE WATSON; Fiscal Year: 2001
    ..The instrument will also detect and quantify levels of acetaminophen and salicylic acid, common sources of childhood poisonings...
  18. PROSTAGLANDIN SYNTHESIS IN HUMAN PLATELETS
    Gerald Roth; Fiscal Year: 1980
    ..Recent results indicate that aspirin (acetyl salicylic acid) acetylates PG synthetase at a single serine residue (J. Biol Chem...
  19. MOLECULAR BASIS OF PATHOGEN INDUCED CELL DEATH IN PLANTS
    JEAN GREENBERG; Fiscal Year: 2000
    ..These pathways require two signals: the known signal molecule salicylic acid and an as yet uncharacterized signal...
  20. Dietary Isothiocyanates in Cancer Prevention: Effects of Estrogen Metabolism
    Marilyn Morris; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  21. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..proposed in this application emanates from our recent success in utilizing ETE for sampling of drugs such as salicylic acid, acyclovir, ibuprofen, fluconazole and cefpodoxime from the dermal ECF...
  22. Molecular Basis of Pathogen-Induced Cell Death in Plants
    JEAN GREENBERG; Fiscal Year: 2009
    ..Because experimental progress using a plant model is rapid, the results obtained and quickly be related to human biology and disease. ..
  23. Clinical Studies with Phospholipid-Associated NSAIDs
    Lenard Lichtenberger; Fiscal Year: 2004
    ..i.d.) with diclofenac-PC, except in this case we will add a third arm of the study in which the subjects are administered the COX- inhibitor, Celecoxib, at a dose (200 mg b.i.d.) having equivalent therapeutic efficacy to diclofenac. ..
  24. PHOSPHOLIPIDS AND ULCER PROTECTION
    Lenard Lichtenberger; Fiscal Year: 2002
    ....
  25. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..It is intended that this program will enable several laboratories to work individually and together to achieve the highest degree of innovating and productivity. ..
  26. Evalulation of Echinacea in a Human Rhinovirus Challenge
    Ronald Turner; Fiscal Year: 2003
    ....
  27. Biomaterials that Promote Healing & Prevent Infection
    JAMES BRYERS; Fiscal Year: 2004
    ..We will quantify macrophage adhesion, cytokine production, and macrophage activation; both with and without the presence of bacteria. ..
  28. Dissecting the innate immune response mediated by Arabidopsis Nudix hydrolase
    Yiji Xia; Fiscal Year: 2010
    ..abstract_text> ..
  29. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  30. ROLE OF THE CELL CYCLE IN HYPERSENSITIVITY TO ESTRADIOL
    Richard Santen; Fiscal Year: 2008
    ..A clinical trial in women, which is designed to specifically demonstrate that high dose estrogen induces tumor regression through the mechanism of apoptosis will be conducted. ..
  31. Dopamine in the Auditory Midbrain: Changes with Deafness and Noise Trauma
    Avril Genene Holt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. CHEMISTRY AND BIOCHEMISTRY OF GLYCOCONJUGATES
    YUAN LEE; Fiscal Year: 2005
    ..These studies are significant from the evolutionary standpoint, since the occurrence of alpha-Gal in glycoproteins is rare in birds, and the responsible transferase seems to be different from that of mammals. ..
  33. Arachidonic Acid Metabolism in Blood and Vascular Cells
    Jun Yang Liou; Fiscal Year: 2006
    ..Information provided by studies from this renewal application will have great impact on understanding the fundamental cytoprotection process and offer an excellent opportunity for developing new therapeutic agents. ..
  34. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  35. Peripherial and Central Mechanisms of Tinnitus Generat
    Carol Bauer; Fiscal Year: 2006
    ..Safe and efficacious therapy for this prevalent and often debilitating problem can only occur with improved understanding of the disorder. ..
  36. Development of Novel Therapeutic Strategy for Sickle Ce*
    EMFEMWONKIEKIE IYAMU; Fiscal Year: 2007
    ..Such an environment maximizes the potential for the P.I. to establish a scientific niche from which an academic career can be constructed. [unreadable] [unreadable]..