polycyclic compounds

Summary

Summary: Compounds consisting of two or more fused ring structures.

Top Publications

  1. ncbi Polycyclic aromatic hydrocarbons air levels in Florence, Italy, and their correlation with other air pollutants
    M Lodovici
    Department of Pharmacology, Viale Pieraccini 6, 50134 Florence, Italy
    Chemosphere 50:377-82. 2003
  2. ncbi Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro
    Alessandra Stacchiotti
    Human Anatomy Unit, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Toxicology 286:48-57. 2011
  3. pmc Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells
    Jian Hong Chu
    Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    World J Gastroenterol 17:2379-88. 2011
  4. pmc A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
    Hui Song
    University of Michigan Comprehensive Cancer Center Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:4700-5. 2005
  5. ncbi Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats
    Tae Hwa Lee
    Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Republic of Korea
    Food Chem Toxicol 50:4239-45. 2012
  6. ncbi Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB
    Rahul Checker
    Radiation Biology and Health Sciences Division, Bio Medical Group, Bhabha Atomic Research Centre, Mumbai 400085, India
    Free Radic Biol Med 53:1421-30. 2012
  7. ncbi Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice
    Si Yuan Pan
    Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100102, China
    J Pharm Pharmacol 60:399-403. 2008
  8. ncbi Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice
    Kam Ming Ko
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Biofactors 34:331-42. 2008
  9. pmc Schisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo
    Yang Xu
    Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Zhejiang, China
    PLoS ONE 6:e28335. 2011
  10. pmc Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid
    Jacqueline F Aitken
    Biochemistry and Molecular Biology Group, School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Biochem J 374:779-84. 2003

Research Grants

  1. MANGANESE (III) BASED OXIDATIVE FREE RADICAL CYCLIZATION
    BARRY SNIDER; Fiscal Year: 2000
  2. Dearomatization of Aromatic Heterocyles
    W Dean Harman; Fiscal Year: 2005
  3. ALKALOID SYNTHESIS VIA 2-ALKENYL-1,2-DIHYDROPYRIDINES
    DANIEL COMINS; Fiscal Year: 1990
  4. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
  5. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
  6. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
  7. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
  8. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
  9. Synthesis of Angelmicin B
    William Lambert; Fiscal Year: 2005
  10. New Methods for the Synthesis of Neurological Agents
    LARRY OVERMAN; Fiscal Year: 2008

Detail Information

Publications218 found, 100 shown here

  1. ncbi Polycyclic aromatic hydrocarbons air levels in Florence, Italy, and their correlation with other air pollutants
    M Lodovici
    Department of Pharmacology, Viale Pieraccini 6, 50134 Florence, Italy
    Chemosphere 50:377-82. 2003
    ..Therefore, in addition to B(a)P, DBA concentration should be considered in the evaluation of air quality in terms of PAH contamination...
  2. ncbi Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro
    Alessandra Stacchiotti
    Human Anatomy Unit, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Toxicology 286:48-57. 2011
    ..This discrepancy might be partly attributable to Sch B influence on glomerular perfusion as corroborated by the recovery of vasoactive markers like macular and endothelial nitric oxide isoforms...
  3. pmc Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells
    Jian Hong Chu
    Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    World J Gastroenterol 17:2379-88. 2011
    ..To investigate the effects of schisandrin B (Sch B) on free fatty acid (FFA)-induced steatosis in L-02 cells...
  4. pmc A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
    Hui Song
    University of Michigan Comprehensive Cancer Center Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:4700-5. 2005
    ..Together, these results demonstrate that STA-21 inhibits breast cancer cells that express constitutively active Stat3...
  5. ncbi Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats
    Tae Hwa Lee
    Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Republic of Korea
    Food Chem Toxicol 50:4239-45. 2012
    ..These results suggest that Schisandrin B treatment provides a neuroprotective effect to rats after transient focal cerebral ischemia by inhibiting inflammation and by protecting against metalloproteinase degradation...
  6. ncbi Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB
    Rahul Checker
    Radiation Biology and Health Sciences Division, Bio Medical Group, Bhabha Atomic Research Centre, Mumbai 400085, India
    Free Radic Biol Med 53:1421-30. 2012
    ..To our knowledge, this is the first report showing that the anti-inflammatory effects of SB are mediated via modulation of Nrf2 and NF-κB in lymphocytes...
  7. ncbi Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice
    Si Yuan Pan
    Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100102, China
    J Pharm Pharmacol 60:399-403. 2008
    ..Fenofibrate treatment (100 mg kg(-1)) produced effects similar to those of Sch B on the hepatic index and lipid levels of hypercholesterolaemic mice...
  8. ncbi Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice
    Kam Ming Ko
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Biofactors 34:331-42. 2008
    ..In conclusion, long-term Sch B supplementation mitigated age-dependent impairments in mitochondrial antioxidant capacity and functional ability, thereby retarding the aging process in mice, particularly during early aging...
  9. pmc Schisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo
    Yang Xu
    Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Zhejiang, China
    PLoS ONE 6:e28335. 2011
    ..In this study, we attempted to prove if Sch B could also protect against Dox-induced chronic cardiotoxicity, a more clinically relevant issue, without compromising its anticancer activity...
  10. pmc Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid
    Jacqueline F Aitken
    Biochemistry and Molecular Biology Group, School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Biochem J 374:779-84. 2003
    ..These findings show that polycyclic compounds can suppress the formation of amyloid by human amylin, providing support for an alternative approach to ..
  11. pmc Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver
    S P Ip
    Department of Biochemistry, The Hong Kong University of Science and Technology, Kowloon, People's Republic of China
    Cell Stress Chaperones 6:44-8. 2001
    ..The relevance of Sch B-induced increase in Hsp70 expression to the prevention of TNFalpha-triggered hepatic apoptosis remains to be elucidated...
  12. ncbi Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells
    Po Yee Chiu
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Biofactors 26:221-30. 2006
    ..In conclusion, the results indicate that the cytoprotective action of Sch B is causally related to the increase in cellular GSH level, which is likely mediated by the enhancement of GSH synthesis and regeneration...
  13. ncbi Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver
    Po Yee Chiu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Life Sci 77:2887-95. 2005
    ..Taken together, the results suggest that oxidant species generated from P-450-catalyzed reaction with Sch B may trigger the antioxidant and heat shock responses in mouse liver...
  14. ncbi Preparation of new polycyclic compounds derived from benzofurans and furochromones. An approach to novel 1,2,3-thia-, and selena-diazolofurochromones of anticipated antitumor activities
    Sanaa M Sh Atta
    Department of the Chemistry of Natural and Microbial Products, National Research Centre, El Behoos Street, Dokki, 12622 Cairo, Egypt
    Eur J Med Chem 45:4920-7. 2010
    ....
  15. ncbi Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography
    Tianhui Huang
    Institute of Chemical and Pharmaceutical, East China University of Science and Technology, 897, 130 Meilong Road, Shanghai 200237, China
    J Chromatogr A 1066:239-42. 2005
    ....
  16. ncbi Screening vasoconstriction inhibitors from traditional Chinese medicines using a vascular smooth muscle/cell membrane chromatography-offline-liquid chromatography-mass spectrometry
    Xingxin Yang
    College of Pharmacy, Shanxi Medical University, Taiyuan, P R China
    J Sep Sci 34:2586-93. 2011
    ..Our VSM/CMC-offline-LC-MS/MS method can be applied for screening vasoconstriction inhibitors from TCMs collected from FSC and FSS, and may be useful in the development of vasodilators from natural products...
  17. ncbi Schisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathways
    Eun Jung Park
    Department of Physiology, Seoul National University College of Medicine, Seoul 110 799, South Korea
    Biochem Pharmacol 83:378-84. 2012
    ..chinensis extract and SchB inhibit TGFβ1 signaling. Our results may help future investigations to understand vascular fibrosis pathogenesis and to develop novel therapeutic strategies for treatment of vascular fibrotic diseases...
  18. ncbi Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis
    Su Yeon Oh
    Department of Biology Education, College of Education, Chungbuk National University, Chungcheongbuk Do, Republic of Korea
    Biosci Biotechnol Biochem 74:285-91. 2010
    ..These inhibitory effects were found to be caused by blockage of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK 1/2), and c-Jun N-terminal kinase (JNK) phosphorylation...
  19. ncbi Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats
    Na Chen
    Department of Biochemistry, The Hong Kong University of Science and Technology, Hong Kong, SAR, China
    Biol Pharm Bull 31:1387-91. 2008
    ..In conclusion, long-term Sch B treatment could enhance cerebral mitochondrial antioxidant status as well as improve mitochondrial structural integrity, thereby protecting against I/R injury...
  20. ncbi Schisandrin B prevents doxorubicin-induced cardiotoxicity via enhancing glutathione redox cycling
    Ling Li
    Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, China
    Clin Cancer Res 13:6753-60. 2007
    ....
  21. ncbi A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats
    Gang Wu
    Purdue Pharma Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Eur J Pharmacol 504:45-53. 2004
    ..Its efficacy demonstrates the importance of peripheral P2X3/P2X(2/3) receptors in mediating ATP-associated mechanical hyperalgesia following inflammation, confirming previous suggestions of a significant role for P2X(2/3)...
  22. ncbi Schisandrin B-induced glutathione antioxidant response and cardioprotection are mediated by reactive oxidant species production in rat hearts
    Na Chen
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Biol Pharm Bull 33:825-9. 2010
    ..Taken together, these results suggest that Sch B-induced glutathione antioxidant response and cardioprotection may be mediated by ROS arising from CYP-catalyzed reaction...
  23. ncbi Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice
    Vijayasree V Giridharan
    Department of Functional and Analytical Food Sciences, Niigata University of Pharmacy and Applied Life Sciences NUPALS, Niigata City, Japan
    Free Radic Res 46:50-60. 2012
    ..Hence, Sch B with potent antioxidant and neuro-protective property with no mutagenic activity would be beneficial complementary food factor against cDDP induced oxidative stress...
  24. ncbi Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells
    Ling Li
    The Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, PR China
    Biochem Pharmacol 71:584-95. 2006
    ..Therefore, it is speculative that Sch B may bring benefit to clinical chemotherapy by reducing significantly the cumulative doses of DOX and its associated cardiotoxicities...
  25. pmc Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response
    Hiroshi Nishida
    Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956 8603, Japan
    Nucleic Acids Res 37:5678-89. 2009
    ..Taken together, our demonstration of the ability of SchB to inhibit ATR protein kinase activity following DNA damage in cells has clinical implications in anti-cancer therapy...
  26. ncbi Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells
    Philip Y Lam
    Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Biofactors 37:439-46. 2011
    ....
  27. pmc Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration
    Steve McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9 1, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Br J Pharmacol 140:1381-8. 2003
    ..Intrathecal administration of A-317491 appears to be more effective than intraplantar administration to reduce tactile allodynia following peripheral nerve injury...
  28. ncbi Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats
    Po Yee Chiu
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Mol Cell Biochem 266:139-44. 2004
    ..The results indicate that the induction of Hsp25 and Hsp70 expression contributes at least partly to the cardioprotection afforded by Sch B pre-treatment against I-R injury...
  29. ncbi Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1
    Meng Sun
    The Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China
    Cancer Lett 246:300-7. 2007
    ....
  30. ncbi Assessment of PAHs in soil around the International Airport in Delhi, India
    Sharmila Ray
    Pollution Monitoring Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India
    J Hazard Mater 156:9-16. 2008
    ..Predominance of pyrene was observed in the airport soil. Factor analysis and isomer pair ratios suggest pyrogenic origin of PAHs in the study area...
  31. ncbi Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain
    Kam Ming Ko
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, China
    Mol Cell Biochem 238:181-6. 2002
    ..The ensemble of results suggests the antioxidant potential of Sch B pretreatment in protecting against cerebral oxidative stress...
  32. pmc Monochloramine-induced toxicity and dysregulation of intracellular Zn2+ in parietal cells of rabbit gastric glands
    Jonathan E Kohler
    Department of Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 299:G170-8. 2010
    ....
  33. ncbi Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes
    Pou Kuan Leong
    Section of Biochemistry and Cell Biology, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, PR China
    Free Radic Res 45:483-95. 2011
    ..In conclusion, (-)Sch B triggers a redox-sensitive ERK/Nrf2 signalling, which then elicits a cellular glutathione antioxidant response and protects against oxidant-induced apoptosis in AML12 cells...
  34. ncbi Miniaturised analytical procedure of determining polycyclic aromatic hydrocarbons and polychlorinated biphenyls in bottom sediments
    Lidia Wolska
    Department of Analytical Chemistry, Chemical Faculty, Technical University of Gdansk, Poland
    J Chromatogr A 959:173-80. 2002
    ..The interlaboratory study proved that the developed procedure for the simultaneous determination of PAHs and PCBs at largely different concentrations in sediment gives accurate and precise results...
  35. ncbi Detection and imaging of zinc secretion from pancreatic beta-cells using a new fluorescent zinc indicator
    Kyle R Gee
    Molecular Probes, Inc, 4849 Pitchford Avenue, Eugene, Oregon 97402, USA
    J Am Chem Soc 124:776-8. 2002
    ..Also, within secreting cells some regions of the cell membrane gave rise to secretion while others did not, suggesting active zones of secretion on the cell surface...
  36. ncbi Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3
    Michael J Devinney
    Department of Pharmacology, University of Pittsburgh School of Medicine, W1351 BST, Pittsburgh, PA 15261, USA
    Cell Calcium 37:225-32. 2005
    ..These studies provide a novel method for the simultaneous detection of both calcium and zinc in cells...
  37. ncbi Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats
    Po Yee Chiu
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Biogerontology 7:199-210. 2006
    ..The results suggest that chronic Sch B treatment may be beneficial for reversing the mitochondrial changes with aging and enhancing the heat shock response...
  38. ncbi Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae
    Min Huang
    Division of Oncology, Department of Internal Medicine, Stanford University, Stanford, CA 94301, USA
    Cancer Chemother Pharmacol 62:1015-26. 2008
    ..Chemically, the five schizandins are derivatives of dibenzo-(a, c)-cyclooctene lignan with distinct structures differing from any known MDR reversal agents...
  39. ncbi Detection of dechlorane plus in residential indoor dust in the city of Ottawa, Canada
    Jiping Zhu
    Chemistry Research Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada K1A 0K9
    Environ Sci Technol 41:7694-8. 2007
    ..S. Environmental Protection Agency. The large variation of the ratio of syn- and anti-DP isomers in the dust samples also suggests a complex degradation process of DP in the environment...
  40. ncbi Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein
    Qiangrong Pan
    The Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, People s Republic of China
    Cancer Chemother Pharmacol 58:99-106. 2006
    ..To determine if five dibenzocyclooctadiene lingnans, a class of naturally occurring compounds from Schisandra chinensis (Turcz.) Baill, have the activities to reverse P-glycoprotein (P-gp) mediated multidrug resistance (MDR)...
  41. ncbi Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes
    Po Yee Chiu
    Department of Biochemistry, Hong Kong University of Science and Technology, SAR, China
    Pharmacology 77:63-70. 2006
    ..The results indicate that (-)Sch B is more effective than (+)Sch B in enhancing cellular GSH and protecting against oxidant injury in hepatocytes...
  42. ncbi Schizandrin reverses memory impairment in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Phytother Res 22:49-52. 2008
    ..Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits...
  43. ncbi Schisandrin B--a novel inhibitor of P-glycoprotein
    Pan Qiangrong
    The Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, People s Republic of China
    Biochem Biophys Res Commun 335:406-11. 2005
    ..Schisandrin B has a core structure of dibenzocyclooctadiene, representing a novel P-glycoprotein inhibitor. To our best knowledge, the role of schisandrin B to inhibit P-glycoprotein has not been reported...
  44. ncbi Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells
    Yi Feng Wu
    College of Life Sciences, Zhejiang University, Hangzhou 310027, Zhejiang Province, China
    World J Gastroenterol 10:2944-8. 2004
    ..To investigate the effect of schisandrin B (Sch B) on proliferation and apoptosis of human hepatoma SMMC-7721 cells in vitro and regulation of Hsp70 and Caspases-3, 7, 9 expression by Sch B...
  45. pmc Polycyclic compounds by Ugi-Pictet-Spengler sequence
    Wei Wang
    Drug Discovery Institute, University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15261, United States
    J Org Chem 76:637-44. 2011
    ..The compound structures resemble steroid hormones and alkaloid classes of natural products. Exemplary products have been fully reduced to their tertiary amines. As such they could potentially become interesting biological probes...
  46. ncbi Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways
    Pornthip Waiwut
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Mol Cell Biochem 350:169-75. 2011
    ..The findings suggested that gomisin N enhanced TNF-α-induced apoptosis by suppressing of NF-κB and EGFR signaling pathways...
  47. ncbi Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats
    Philip Y Lam
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Fitoterapia 81:1239-45. 2010
    ..Long-term Sch B treatment enhanced mitochondrial antioxidant status in a tissue non-specific manner. Sch B co-treatment ameliorated the alterations in plasma ROM levels, mtMDA production and Hsp 25/70 expression in rat tissues...
  48. ncbi Environmental exposure of small children to polycyclic aromatic hydrocarbons
    Z Fiala
    Department of Hygiene and Preventive Medicine, Charles University in Prague, Medical Faculty in Hradec Kralove, Czech Republic
    Int Arch Occup Environ Health 74:411-20. 2001
    ..The aim of the study was to assess the intake (by various routes of exposure) of polycyclic aromatic hydrocarbons (PAH) by children living in a Czech city, and its effect on excretion of 1-hydroxypyrene (1-OHP) in summer and winter periods...
  49. ncbi Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells
    Po Yee Chiu
    Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Mol Cell Biochem 350:237-50. 2011
    ..The ERK-mediated signaling is also likely involved in the cardioprotection afforded by Sch B in vivo...
  50. ncbi Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts
    K M Ko
    Department of Biochemistry, The Hong Kong University of Science and Technology, Kowloon, China
    Mol Cell Biochem 220:141-7. 2001
    ..The ensemble of results suggests that the cardioprotection afforded by Sch B or LA pretreatment may at least in part be attributed to the modulation on the interplay among non-enzymatic antioxidants under oxidative stress induced by IR...
  51. ncbi The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors
    M T Hsieh
    Institute of Chinese Pharmaceutical Sciences, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, 40421, Republic of China
    Pharmacol Res 43:17-22. 2001
    ....
  52. ncbi (-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells
    Philip Y Lam
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Biofactors 37:51-7. 2011
    ..The results suggest that (-)Sch B treatment may increase the resistance of dopaminergic cells against PQ-induced oxidative stress through reducing the extent of oxidant-induced GSH depletion and enhancing the subsequent GSH recovery...
  53. ncbi Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions
    Ohyun Kwon
    Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 124:13402-4. 2002
    ..Skeletal diversity, a difficult challenge in DOS, was achieved with a branching reaction pathway using one or two Diels-Alder reactions. This pathway yields small molecules having 10 different skeletons...
  54. ncbi Dechlorane plus and related compounds in the environment: a review
    Ed Sverko
    Science and Technology Branch, Environment Canada, Burlington, ON, L7R 4A6, Canada
    Environ Sci Technol 45:5088-98. 2011
    ..In particular, there is a need to obtain more monitoring, bioaccumulation, degradation rate, and toxicity information...
  55. ncbi Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice
    Vijayasree V Giridharan
    Department of Functional and Analytical Food Sciences, Niigata University of Pharmacy and Applied Life Sciences NUPALS, Niigata City 956 8603, Japan
    Free Radic Res 45:950-8. 2011
    ....
  56. ncbi Sources and environmental behavior of dechlorane plus--a review
    Qiming Xian
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210046, China
    Environ Int 37:1273-84. 2011
    ..With only limited data available so far, the biomagnification of DP in aquatic biota has not been conclusively demonstrated. This review also looks at reported dechlorination products of DP that might be of interest in future research...
  57. pmc A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
    Michael F Jarvis
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    Proc Natl Acad Sci U S A 99:17179-84. 2002
    ....
  58. ncbi [3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors
    Michael F Jarvis
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, USA
    J Pharmacol Exp Ther 310:407-16. 2004
    ..These data demonstrate that [3H]A-317491 is the first useful radioligand for the specific labeling of P2X3-containing channels...
  59. ncbi Calyciphylline D, a novel alkaloid with an unprecedented fused-pentacyclic skeleton from Daphniphyllum calycinum
    Shizuka Saito
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Org Lett 9:1207-9. 2007
    ..2.1.0.4,8]nonane ring system, has been isolated from the leaves of Daphniphyllum calycinum (Daphniphyllaceae), and the structure and relative stereochemistry were elucidated on the basis of spectroscopic data...
  60. ncbi Two-dimensional porous molecular networks of dehydrobenzo[12]annulene derivatives via alkyl chain interdigitation
    Kazukuni Tahara
    Division of Frontier Materials Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560 8531, Japan
    J Am Chem Soc 128:16613-25. 2006
    ..The solvent dramatically changes the structure of the DBA networks. The solvent effects are discussed in terms of factors that influence the mobility of molecules at the liquid-solid interface such as solvation...
  61. ncbi Metal-mediated efficient synthesis, structural characterization, and skeletal rearrangement of octasubstituted semibullvalenes
    Chao Wang
    Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China
    J Am Chem Soc 128:4564-5. 2006
    ..The structures of these semibullvalenes were determined by single-crystal X-ray structural analysis. Their intramolecular skeletal rearrangement and reaction chemistry were investigated...
  62. pmc Stereoselective cascade reactions that incorporate a 7-exo acyl radical cyclization
    Seth W Grant
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    Org Lett 8:1867-70. 2006
    ..The relative configurations of the products are consistent with cyclizations occurring via chairlike or pseudochairlike transition states...
  63. ncbi Solution- and solid-phase, modular approaches for obtaining different natural product-like polycyclic architectures from an aminoindoline scaffold for combinatorial chemistry
    P Thirupathi Reddy
    Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario, Canada, K1A 0R6
    J Comb Chem 8:856-71. 2006
    ....
  64. ncbi [Deterimination of schisandrin in Kadsura heteroclita (Roxb.) Craib by RP-HPLC]
    Wen Weng
    Jinan University, Guangzhou 510632, China
    Zhong Yao Cai 29:567-9. 2006
    ..To develop a method of RP-HPLC for determination of schisandrin content in Kadsura heteroclita (Roxb.) Craib...
  65. ncbi Stereoselective preparation of six diastereomeric quatercyclopropanes from bicyclopropylidene and some derivatives
    Malte von Seebach
    Institut fur Organische und Biomolekulare Chemie der Georg August Universitat Gottingen, Tammannstrasse 2, 37077 Gottingen, Germany
    Chemistry 13:167-77. 2007
    ..1, 4.7, 5.9 and 5.9 Hz, respectively. This indicates a predominance of the all-gauche conformer in (R*,S*,R*,S*)-17 and a decreasing fraction of it in this sequence of the other diastereomers...
  66. ncbi Total synthesis and structure assignment of (+)-hexacyclinol
    John A Porco
    Department of Chemistry, Boston University, Boston, MA 02215, USA
    Angew Chem Int Ed Engl 45:5790-2. 2006
  67. ncbi (-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes
    Po Yee Chiu
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Mol Cell Biochem 289:185-91. 2006
    ..The results indicate that (-)Sch B produces more potent enhancing effects on cellular GSH and Hsp production as well as protection against oxidative injury than (+)Sch B in cardiomyocytes...
  68. ncbi Rhodium-catalyzed asymmetric one-pot transesterification and [2 + 2 + 2] cycloaddition leading to enantioenriched 3,3-disubstituted phthalides
    Ken Tanaka
    Department of Applied Chemistry, Graduate School of Engineering, and Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan
    Org Lett 9:1307-10. 2007
    ..The present method represents a versatile new route to the synthesis of enantioenriched tricyclic 3,3-disubstituted phthalides in view of the easy access to both coupling partners...
  69. ncbi Synthetic studies on maitotoxin. 1. Stereoselective synthesis of the C'D'E'F'-ring system having a side chain
    Masayuki Morita
    RIKEN, The Institute of Physical and Chemical Research, Saitama, Japan
    Org Lett 10:1675-8. 2008
    ..The key reactions include Horner-Wadsworth-Emmons coupling of the C'D'E'-ring and the side chain and subsequent construction of the F'-ring by silane reduction of dihydropyran...
  70. ncbi Reagent-based, modular, tandem Michael approach for obtaining different indoline alkaloid-inspired polycyclic architectures
    Jean Louis Brochu
    Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
    J Comb Chem 10:405-20. 2008
    ..By simply changing the Lewis acid to TMSOTf, we were able to obtain a different tetracyclic compound having additional functionalized 5- and 7-membered rings with complete stereocontrol...
  71. ncbi Synthetic studies on maitotoxin. 3. Stereoselective synthesis of the BCDE-ring system
    Masanori Satoh
    Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo, Japan
    Org Lett 10:1683-5. 2008
    ..The key reactions involve SmI 2-induced double cyclization of a beta-alkoxyacrylate and a double dihydroxylation for construction of the B- and E-rings...
  72. ncbi Total synthesis of (+/-)-stemonamide and (+/-)-isostemonamide using a radical cascade
    Tsuyoshi Taniguchi
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Org Lett 10:197-9. 2008
    ..Total synthesis of stemonamide and isostemonamide is described. The concise construction of the tricyclic core of these alkaloids was achieved by radical cascade involving 7-endo and 5-endo cyclizations...
  73. ncbi Alternating iodonium-mediated reaction cascades giving indole- and quinoline-containing polycycles
    Rosliana Halim
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia
    Org Lett 10:1967-70. 2008
    ..Simply by changing the reaction conditions, this protocol can be directed down an alternative domino reaction cascade to give various ring fused quinoline compounds C...
  74. ncbi Determination of deoxyschizandrin in rat plasma by LC-MS
    Xinxiu Deng
    Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China
    J Pharm Biomed Anal 46:121-6. 2008
    ..8+/-3.1 and 34.3+/-16.8 ng/ml, T(max) were 0.51+/-0.13 and 3.83+/-1.83 h, T(1/2) were 5.3+/-2.2 and 6.5+/-3.4h...
  75. ncbi Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes
    Po Yee Chiu
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Life Sci 82:1092-101. 2008
    ....
  76. ncbi Towards configurationally stable [4]helicenes: enantioselective synthesis of 12-substituted 7,8-dihydro[4]helicene quinones
    M Carmen Carreño
    Departamento de Quimica Organica C I, Universidad Autonoma Madrid, Cantoblanco, 28049 Madrid, Spain
    Chemistry 14:603-20. 2008
    ..Our study provided evidence that, in addition to steric effects, a small but significant role of electronic effects is governing the configurational stability of such helical quinones...
  77. ncbi Synthesis and biological evaluation of rigid polycyclic derivatives of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione
    Felicia Megumi Ito
    Department of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil
    Molecules 12:271-82. 2007
    ..2.1.0(2,7)]undeca-4,9-dien-3,6-dione in order to obtain cage-like compounds and derivatives, followed by an evaluation of their biological activity...
  78. ncbi Neglschisandrins A-B: two new dibenzocyclooctene lignans from Schisandra neglecta
    Min Chen
    School of Pharmacy, Key Laboratory of Eco environments in Three Gorges Reservoir Region Ministry of Education, Southwest University, Chongqing 400715, PR China
    Molecules 13:548-55. 2008
    ..Their structures and stereochemistries were elucidated by spectroscopic methods, including 1D- and 2D-NMR and HR-ESI-MS techniques...
  79. ncbi Nordihydroguaiaretic acid autoxidation produces a schisandrin-like dibenzocyclooctadiene lignan
    Jennifer L Billinsky
    Graduate Toxicology Program, University of Saskatchewan, Saskatoon, SK Canada
    J Nat Prod 71:1612-5. 2008
    ....
  80. ncbi Chiral discrimination in the 13C and 2H NMR of the crown and saddle isomers of nonamethoxy-cyclotriveratrylene in chiral liquid-crystalline solutions
    Olivier Lafon
    Laboratoire de Chimie Structurale Organique, Equipe RMN en Milieu Orienté, ICMMO, CNRS UMR 8182, Bat 410, Universite de Paris Sud XI, 91405 Orsay, France
    J Phys Chem B 111:9453-67. 2007
    ..A detailed analysis of the effect is presented, and it is argued that the discrimination observed for s-1 reflects the different ordering of its enantiomers during the pseudorotation cycle...
  81. ncbi Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice
    Bomi Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:1153-6. 2007
    ..Schizandrin reduced the protein expressions of TNF-alpha and IL-4 in IgE-induced RBL 2H3 cells. These findings suggest that schizandrin can improve IgE-induced anaphylaxis and scratching behaviors...
  82. ncbi Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers
    Po Yee Chiu
    Department of Biochemistry, The Hong Kong University of Science and Technology, Hong Kong SAR, China
    Biol Pharm Bull 30:1108-12. 2007
    ..In conclusion, the results suggest that the hepatoprotection afforded by Sch B pretreatment against CCl4 toxicity may be related to the increase in the resistance of hepatic mitochondria to Ca2+-stimulated PT...
  83. ncbi Amyloid-beta-induced cytotoxicity of PC-12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction
    Hiroshi Nishida
    Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    J Pharmacol Sci 104:73-81. 2007
    ..It may also be beneficial not only for the treatment of brain disorders but also for other diseases caused by oxidative stress...
  84. ncbi Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport
    Vamsi L M Madgula
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, MS 38677, USA
    J Pharm Pharmacol 60:363-70. 2008
    ..Poor transport of schisandrin C was observed which could not be quantitated. The permeability of gomisin A in the isolated form was significantly different compared with the mixture or extract...
  85. ncbi Stereospecific synthesis of hetero[7]helicenes by Pd-catalyzed double N-arylation and intramolecular O-arylation
    Koji Nakano
    Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Angew Chem Int Ed Engl 44:7136-8. 2005
  86. ncbi Total synthesis of (+)-isoschizandrin utilizing a samarium(II) iodide-promoted 8-endo ketyl-olefin cyclization
    Gary A Molander
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
    J Org Chem 68:9533-40. 2003
    ..In constructing (+)-isoschizandrin as a single atropisomer, the synthesis utilizes a kinetic resolution of a seven-membered lactone using a CBS-oxazaborolidine...
  87. ncbi Structural elucidation of A-74528, an inhibitor for 2',5'-phosphodiesterase isolated from Streptomyces sp
    Yoko Fujita
    Sankyo R and D Facility, Sankyo Co Ltd, 2 58, Hiromachi 1 Chome, Shinagawa ku, Tokyo 140 8710, Japan
    Bioorg Med Chem Lett 15:4317-21. 2005
    ..It was proved that 1 is a highly fused polyketide with a side-chain branching site that never appeared before from the nature...
  88. ncbi Application of preparative high-speed counter-current chromatography for isolation and separation of schizandrin and gomisin A from Schisandra chinensis
    Jinyong Peng
    Shanghai Key Laboratory for Pharmaceutical Metabolite Research, School of Pharmacy, Second Military Medical University, No 325 Guohe Road, Shanghai 200433, China
    J Chromatogr A 1082:203-7. 2005
    ..5% and 99.1% were obtained from 400 mg crude extract in one-step elution and less than 3 h, and the structure identification was performed by UV, IR, MS, 1H NMR and 13C NMR...
  89. ncbi Steroids and steroid analogues from Stille-Heck coupling sequences
    Hans Wolf Sünnemann
    Institut für Organische Chemie der Georg August Universität Göttingen, Tammannstrasse 2, 37077 Gottingen, Germany
    Angew Chem Int Ed Engl 43:895-7. 2004
  90. ncbi Stereoselective syntheses of the C'D'E'F'-ring system of maitotoxin and the FG-ring system of gambierol
    Y Sakamoto
    RIKEN (The Institute of Physical and Chemical Research, Wako, Saitama 351-0198, Japan
    Org Lett 3:2749-52. 2001
    ..The key steps involve 6-endo-cyclization of methylepoxide, SmI2-induced reductive cyclization, 6-endo-cyclization of vinylepoxide, and formation of the lactone ring...
  91. ncbi Halogenoalkyl isocyanates as bifunctional reagents in an Aza-Wittig/heterocyclization reaction on the solid phase: efficient entry into new tetracyclic benzimidazole systems
    Cornelia E Hoesl
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    J Comb Chem 6:220-3. 2004
    ..The structure of the tetracyclic ring system was determined by two-dimensional NMR experiments and X-ray analysis...
  92. ncbi [Determination of schisandrin in shengmaiyin by HPLC]
    Xiao Feng Wu
    Medical College of Chinese People s Armed Police Forces, Tianjin 300162, China
    Zhongguo Zhong Yao Za Zhi 28:39-40, 72. 2003
    ..To determine the concentration of schisandrin in Shengmaiyin with HPLC...
  93. ncbi Stereocontrolled solid-phase synthesis of a 90-membered library of indoline-alkaloid-like polycycles from an enantioenriched aminoindoline scaffold
    Zhonghong Gan
    Chemical Biology Program, Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada
    Angew Chem Int Ed Engl 44:1366-8. 2005
  94. ncbi The dihydroxyacetone unit--a versatile C(3) building block in organic synthesis
    Dieter Enders
    Institut fur Organische Chemie, Rheinisch Westfalische Technische Hochschule, Professor Pirlet Strasse 1, 52074 Aachen, Germany
    Angew Chem Int Ed Engl 44:1304-25. 2005
    ..Furthermore, the related 1,3-dioxins are useful equivalents of 2-substituted acrolein derivatives...
  95. ncbi Theoretical (DFT, GIAO-NMR, NICS) study of carbocations (M+H)+, dications (M2+) and dianions (M2-) from dihydro-dicyclopenta[ef,kl]heptalene (dihydro-azupyrene), dihydro-dicyclohepta[ed,gh]pentalene, and related bridged [14]annulenes
    Takao Okazaki
    Department of Chemistry, Kent State University, Kent, OH 44242, USA
    Org Biomol Chem 3:286-94. 2005
    ..A basis-set dependency study of the computed GIAO chemical shifts was also undertaken. The present DFT work represents the first detailed comparative theoretical study of charged annulenes derived from the dihydro derivatives of and ...
  96. ncbi Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for
    Tsutomu Hoshino
    Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi, Niigata 950 2181, Japan
    Org Biomol Chem 2:1456-70. 2004
    ..4) Some of the novel terpene skeletons, 36, 37, 39 and 40, were created from the analogs employed in this investigation...
  97. ncbi Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract
    Hiroshi Iwata
    Division of Natural Products Chemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930 0194, Japan
    Drug Metab Dispos 32:1351-8. 2004
    ..This pattern is consistent with the metabolism of the methylenedioxy substituent in gomisin C. These results indicate that gomisin C is a mechanism-based inhibitor that not only competitively inhibits but irreversibly inactivates CYP3A4...
  98. ncbi Synthesis of the ABCD ring of gambierol
    Hiroki Furuta
    Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468 8503, Japan
    Org Lett 7:4061-4. 2005
    ..A fully functionalized ABCD ring moiety of gambierol, a marine polycyclic ether toxin, was synthesized by the use of the oxiranyl anion strategy and reductive cycloetherification of a beta,delta-dihydroxy ketone...
  99. ncbi Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells
    Kam Ming Ko
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Mol Cell Biochem 276:227-34. 2005
    ....
  100. ncbi New synthesis of (S)-dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethenedioxy-biphenyl-2,2'-dicarboxylate by configuration transform
    Sen xiang Cheng
    Center of Research, Henan Academy of Science, Zhengzhou, Henan 450002, China
    Bioorg Med Chem Lett 14:1665-7. 2004
    ..The C(2)-symmetric biphenyl, (S)-dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethenedioxy-biphenyl-2,2'-dicarboxylate was prepared easily via the hydrolysis and ester exchange of (S)-3...
  101. ncbi Helical structure of tercyclopropanedimethanol in solution
    Anthony G M Barrett
    Department of Chemistry, Imperial College, South Kensington, London SW7 2AY, United Kingdom
    J Org Chem 71:2756-9. 2006
    ..However, the crystal structure of the title compound and the solution structure are different...

Research Grants62

  1. MANGANESE (III) BASED OXIDATIVE FREE RADICAL CYCLIZATION
    BARRY SNIDER; Fiscal Year: 2000
    ..cyclization into a reliable and versatile method for the synthesis of highly functionalized cyclic and polycyclic compounds. The PI's studies over the past ten years have shown that this will be a valuable synthetic method for ..
  2. Dearomatization of Aromatic Heterocyles
    W Dean Harman; Fiscal Year: 2005
    ..Aromatic heterocycles are ideal synthons for functionalized polycyclic compounds. Aromatic heterocycles are widely available, are chemically stable, and yet are readily derivatized...
  3. ALKALOID SYNTHESIS VIA 2-ALKENYL-1,2-DIHYDROPYRIDINES
    DANIEL COMINS; Fiscal Year: 1990
    ..this proposal is to continue our studies on developing practical methods for the synthesis of novel bridged polycyclic compounds and biologically active alkaloids via intramolecular cycloaddition reactions of 1-acyldihydropyridines...
  4. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  5. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  6. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  7. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  8. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  9. Synthesis of Angelmicin B
    William Lambert; Fiscal Year: 2005
    ..Aromatic annulations of the AB- and A'B'-ring systems will give rise to two new polycyclic compounds, and union of these via catalytic asymmetric Suzuki coupling should provide the aglycone of angelmicin B as ..
  10. New Methods for the Synthesis of Neurological Agents
    LARRY OVERMAN; Fiscal Year: 2008
    ..oryzae at 90 nM, suggesting potential antitumor activity. Because of the scarcity of these natural products from their natural sources, little biological evaluation has been carried out. ..
  11. Defining the roles of Metals in Synaptic transmission
    Alan Kay; Fiscal Year: 2007
    ..A thorough understanding of the normal mechanisms of Zn homeostasis and how such mechanisms are altered in neuropathologies will be essential in the development of effective strategies for treatment ..
  12. New Synthetic Routes to Phorbols and Ingananes
    TIMO OVASKA; Fiscal Year: 2003
    ..This basic ring construction strategy will be coupled with other synthetic methodologies to generate structurally and functionally diverse analogues of phorbol and ingenol. ..
  13. PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDS
    LARRY OVERMAN; Fiscal Year: 2009
    ....
  14. Generation of Stereochemically and Structurally Complex Chemical Libraries
    JOHN PORCO; Fiscal Year: 2007
    ..Inclusion of the target libraries that will be developed in this effort in the NIH repository is anticipated to facilitate discovery of new pharmacological tools for investigation of cellular processes. [unreadable] [unreadable]..
  15. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..heterodiene/dipoles offer great potential for the general synthesis of piperidines and piperidine-embedded polycyclic compounds. The basic features of preparation, structure, stability, reactivity (in both [4+2] and [3+2] manifolds) ..
  16. METHODOLOGY FOR THE SYNTHESIS OF NITROGEN HETEROCYCLES
    Philip Magnus; Fiscal Year: 2007
    ..The synthetic intermediates, particularly as they more closely resemble the natural products, will be screened to assess biological activity. [unreadable] [unreadable]..
  17. Admixture Mapping of Sarcoidosis Genes in African American
    Benjamin Rybicki; Fiscal Year: 2007
    ..Our proposed study has the potential to uncover genes of modest effect not easily detectable by linkage and may in some instances actually be more statistically powerful than traditional case-control association methods. ..
  18. FLOURESCENT TOOLS FOR THE STUDY OF METALLOTHIONEIN
    Christopher Frederickson; Fiscal Year: 2006
    ..healthy cell growth. Our tools will facilitate research in all of those areas and contribute to the advancement and development of diagnostic and therapeutic medical science. [unreadable] [unreadable] [unreadable]..
  19. Synthesis of anticancer agents using Prins cyclization
    Scott Rychnovsky; Fiscal Year: 2007
    ..These tools will facilitate the synthesis of many new structures that may be important as new pharmaceutical agents. ..
  20. Designing HTA therapy for drug resistant malaria
    Christian Wolf; Fiscal Year: 2009
    ..Our long term goal is the identification of novel, inexpensive, efficacious therapy for treating drug resistant malaria. ..
  21. New Methodology for Indole Alkaloid Syntheses
    Ken S Feldman; Fiscal Year: 2010
    ..The use of a new variant of the Pummerer reaction to control both oxidation level and reaction site within the indole nucleus forms the basis of this chemistry. ..
  22. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  23. Alkynyliodonium Salts and Derived Diyls in Synthesis
    Ken Feldman; Fiscal Year: 2009
    ..abstract_text> ..
  24. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
    ..Daphnicyclidin A. This recent discovery has revealed a new molecular architecture which exhibits significant antitumor activity. Our research will investigate strategies for chemical synthesis of these complex polycyclic systems. ..
  25. Strategies for the Syntheses of Bioactive Targets
    Stephen Martin; Fiscal Year: 2010
    ..Secondly, the targets we have identified have significant potential as leads for the development of novel anticancer agents having improved biological profiles. ..
  26. Studies of Molecular Recognition in Biological Systems
    Stephen Martin; Fiscal Year: 2010
    ..Such tools are indispensable to medicinal chemists as they optimize ligand binding affinities and transform novel leads into selective and potent therapeutic agents to treat diseases. ..
  27. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  28. Total Synthesis of Anti-Cancer Natural Products
    Phil S Baran; Fiscal Year: 2010
    ..New strategies and methods in chemistry and substantial contributions to medicine are anticipated through strategic collaborations with several leaders in the field of cancer biology. ..
  29. SYNTHESIS OF NITROGEN CONTAINING NATURAL PRODUCTS
    Stephen Martin; Fiscal Year: 2010
    ..Secondly, the synthetic targets we have identified have significant potential as leads for the development of novel anticancer agents. ..
  30. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  31. SYNTHESIS OF CANNABINOIDS, ANALOGUES AND METABOLITES
    John Huffman; Fiscal Year: 2009
    ..There a possibility that these metabolites may be contributing to the enhanced potency of cannabinoids with a dimethylheptyl side chain. ..
  32. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  33. Oxidative Coupling in Natural Product Synthesis
    Phil Baran; Fiscal Year: 2009
    ....
  34. INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 2006
    ..The selective synthesis of contiguous stereotriads will advance basic methodology for asymmetric conjugate additions. ..
  35. Tools For Measuring Free Zinc (pZn) In The Brain
    Christopher Frederickson; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  36. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2004
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  37. THE SYNTHESIS OF LACTONAMYCIN AND ANALOGS
    T Kelly; Fiscal Year: 2003
    ..To test, in collaboration with Pfizer Inc., analogs and synthetic intermediates for antibiotic, anticancer and other biological activities. ..
  38. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  39. K + EFFLUX--ROLE IN CA++ HOMEOSTASIS AND EXCITOTOXICITY
    Lech Kiedrowski; Fiscal Year: 2003
    ..These studies may yield a new target for pharmacological intervention to decrease neuronal death following ischemia or hypoglycemia, namely, to prevent excessive K+ loss from the brain during reperfusion. ..
  40. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2003
    ..The ultimate goal of this proposal is to generate new knowledge that can be used to develop new and better strategies for the control of non-melanoma and melanoma skin cancer. ..
  41. Does Nitric Oxide Control Synaptic Zinc Release?
    Christopher Frederickson; Fiscal Year: 2003
    ..The objective of the present proposal is to establish with certainty whether, in fact, NO controls Zn2+ release during excitotoxicity. ..
  42. Proteins to Population:A metacluster for Bioinformatics
    JULIO FACELLI; Fiscal Year: 2002
    ..These applications range from epidemiological studies of populations to investigations of the mechanics of knees or studies of organ level systems down to detailed atomistic simulations of various biomolecular systems. ..
  43. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
  44. ZINC-BASED DIAGNOSTIC FOR PROSTATE CANCER
    Christopher Frederickson; Fiscal Year: 2002
    ..If a zinc-based test were used along with PSA testing, the sales of the tests could be vast, and the contribution to men's health and wellness, equally vast. ..
  45. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  46. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 2001
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
  47. Acquisition of a 500 MHz NMR Spectrometer
    Scott Rychnovsky; Fiscal Year: 2004
    ..This new instrument will bring much needed new capabilities to the NMR facility and will greatly facilitate the research programs of the PI and co-PIs of this proposal. ..
  48. HIGH-SPEED MICROFLUIDIC SORTING OF BIOHAZARDOUS CELLS.
    Christopher Frederickson; Fiscal Year: 2004
    ..abstract_text> ..
  49. Synthesis of Enamide and Related Natural Products
    JOHN PORCO; Fiscal Year: 2006
    ..We intend to pursue the asymmetric synthesis of novel antitumor and cell-cycle inhibitory macrolide oximidine I. We will pursue the asymmetric synthesis of the antitumor compound zampanolide whose natural resource has been depleted. ..
  50. Study of the Strength of CH-Y (Y =O,N)and XH-pi (X=N,O,S) Interactions
    BENJAMIN GUNG; Fiscal Year: 2006
    ..The understanding of these weak interactions is essential for rational drug design and lead optimization. [unreadable] [unreadable]..
  51. Synthesis of the myrmicarin family of natural products
    Scott Snyder; Fiscal Year: 2005
    ....
  52. Synthesis of Cannabinoid Receptor Ligands
    John Huffman; Fiscal Year: 2005
    ..A number of new classical cannabinoids will be synthesized, including additional 1',2'-dimethylheptyl-delta8-tetrahydrocannabinol analogues and the six geminally disubstituted dimethylheptyl-delta8-tetrahydrocannabinols. ..
  53. Chemical and Biological Studies on Biaryl Phenolics
    Ken Feldman; Fiscal Year: 2005
    ..The search for selective 20S proteosome inhibitors among the Ntn-type proteases will be advanced by these investigations. ..
  54. NEW STRATEGIES FOR GLYCOCONJUGATE SYNTHESIS
    Frank McDonald; Fiscal Year: 2005
    ....
  55. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  56. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 2005
    ..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
  57. Alkyllithium Cyclizations in Organic Snythesis
    Scott Rychnovsky; Fiscal Year: 2005
    ..These compounds are of interest to synthetic and medicinal chemists, and have the types of rigid, polycyclic and polar structures found to show high bioactivity in many assays. ..
  58. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  59. A Molecular Motor
    T Kelly; Fiscal Year: 2004
    ..The project should expand the understanding of chemically directed and controlled movement, which is a topic central to the understanding of biological systems. ..
  60. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  61. SYNTHESIS OF DIAZONAMIDES
    Philip Magnus; Fiscal Year: 2004
    ..Part of the synthetic studies will involve the generation of persistent radical intermediates that should add to pi-deficient heterocycles and form the key central hindered bond present in the diazonamides. ..