cyclopentanes

Summary

Summary: A group of alicyclic hydrocarbons with the general formula R-C5H9.

Top Publications

  1. ncbi Role of plant hormones in plant defence responses
    Rajendra Bari
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Plant Mol Biol 69:473-88. 2009
  2. ncbi JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling
    Bryan Thines
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164 6340, USA
    Nature 448:661-5. 2007
  3. ncbi The JAZ family of repressors is the missing link in jasmonate signalling
    A Chini
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain
    Nature 448:666-71. 2007
  4. pmc JASMONATE-INSENSITIVE1 encodes a MYC transcription factor essential to discriminate between different jasmonate-regulated defense responses in Arabidopsis
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 16:1938-50. 2004
  5. ncbi An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
    Teresa A Soucy
    Discovery, Millennium Pharmaceuticals, Inc, 40 Landsdowne Street, Cambridge, Massachusetts 02139, USA
    Nature 458:732-6. 2009
  6. pmc Jasmonates: an update on biosynthesis, signal transduction and action in plant stress response, growth and development
    C Wasternack
    Department of Natural Product Biotechnology, Leibniz Institute of Plant Biochemistry, Weinberg 3, D 06120 Halle Saale, Germany
    Ann Bot 100:681-97. 2007
  7. pmc Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor
    Laura B Sheard
    Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195, USA
    Nature 468:400-5. 2010
  8. pmc MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis
    Bruno Dombrecht
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland, 4067, Australia
    Plant Cell 19:2225-45. 2007
  9. pmc Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis
    Jonathan P Anderson
    Cooperative Research Centre for Tropical Plant Protection, University of Queensland, St Lucia, Queensland, 4072, Australia
    Plant Cell 16:3460-79. 2004
  10. pmc ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis
    Bruce A T Adie
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 19:1665-81. 2007

Research Grants

Detail Information

Publications305 found, 100 shown here

  1. ncbi Role of plant hormones in plant defence responses
    Rajendra Bari
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Plant Mol Biol 69:473-88. 2009
    ..Here, we review recent advances made in understanding the role of these hormones in modulating plant defence responses against various diseases and pests...
  2. ncbi JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling
    Bryan Thines
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164 6340, USA
    Nature 448:661-5. 2007
    ....
  3. ncbi The JAZ family of repressors is the missing link in jasmonate signalling
    A Chini
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain
    Nature 448:666-71. 2007
    ..Furthermore, we demonstrate the existence of a regulatory feed-back loop involving MYC2 and JAZ proteins, which provides a mechanistic explanation for the pulsed response to jasmonate and the subsequent desensitization of the cell...
  4. pmc JASMONATE-INSENSITIVE1 encodes a MYC transcription factor essential to discriminate between different jasmonate-regulated defense responses in Arabidopsis
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 16:1938-50. 2004
    ....
  5. ncbi An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
    Teresa A Soucy
    Discovery, Millennium Pharmaceuticals, Inc, 40 Landsdowne Street, Cambridge, Massachusetts 02139, USA
    Nature 458:732-6. 2009
    ..MLN4924 suppressed the growth of human tumour xenografts in mice at compound exposures that were well tolerated. Our data suggest that NAE inhibitors may hold promise for the treatment of cancer...
  6. pmc Jasmonates: an update on biosynthesis, signal transduction and action in plant stress response, growth and development
    C Wasternack
    Department of Natural Product Biotechnology, Leibniz Institute of Plant Biochemistry, Weinberg 3, D 06120 Halle Saale, Germany
    Ann Bot 100:681-97. 2007
    ..Many of them alter gene expression positively or negatively in a regulatory network with synergistic and antagonistic effects in relation to other plant hormones such as salicylate, auxin, ethylene and abscisic acid...
  7. pmc Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor
    Laura B Sheard
    Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195, USA
    Nature 468:400-5. 2010
    ..Our results unravel the mechanism of jasmonate perception and highlight the ability of F-box proteins to evolve as multi-component signalling hubs...
  8. pmc MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis
    Bruno Dombrecht
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland, 4067, Australia
    Plant Cell 19:2225-45. 2007
    ..Overall, these results provide new insights into the function of MYC2 and the transcriptional coordination of the JA signaling pathway...
  9. pmc Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis
    Jonathan P Anderson
    Cooperative Research Centre for Tropical Plant Protection, University of Queensland, St Lucia, Queensland, 4072, Australia
    Plant Cell 16:3460-79. 2004
    ....
  10. pmc ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis
    Bruce A T Adie
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 19:1665-81. 2007
    ..The results support a model for ABA affecting JA biosynthesis in the activation of defenses against this oomycete...
  11. pmc ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate pathways in plant defense
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 15:165-78. 2003
    ....
  12. pmc The JAZ proteins: a crucial interface in the jasmonate signaling cascade
    Laurens Pauwels
    Department of Plant Systems Biology, VIB, B 9052 Ghent, Belgium
    Plant Cell 23:3089-100. 2011
    ..Overall, these contemporary findings underscore the value of protein-protein interaction studies to acquire fundamental insight into molecular signaling pathways...
  13. pmc The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses
    Patricia Fernández-Calvo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 23:701-15. 2011
    ..Our results show that MYC3 and MYC4 are activators of JA-regulated programs that act additively with MYC2 to regulate specifically different subsets of the JA-dependent transcriptional response...
  14. ncbi Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack
    Martin De Vos
    Graduate School Experimental Plant Sciences, Section Phytopathology, Department of Biology, Utrecht Faculty of Science, Utrecht University, P O Box 800 84, 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 18:923-37. 2005
    ....
  15. pmc The outcomes of concentration-specific interactions between salicylate and jasmonate signaling include synergy, antagonism, and oxidative stress leading to cell death
    Luis A J Mur
    Institute of Biological Science, University of Wales, Aberystwyth, United Kingdom
    Plant Physiol 140:249-62. 2006
    ..Our data suggests that the outcomes of JA-SA interactions could be tailored to pathogen/pest attack by the relative concentration of each hormone...
  16. pmc Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormonal responses in Arabidopsis
    Yong Hwa Cheong
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Plant Physiol 129:661-77. 2002
    ..These results further dissected the nature of mechanical wounding as a stress signal and identified new genes that may play a role in wounding and other signal transduction pathways...
  17. pmc COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine
    Leron Katsir
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 105:7100-5. 2008
    ..These findings demonstrate that COI1 is a critical component of the JA receptor and that COR exerts its virulence effects by functioning as a potent agonist of this receptor system...
  18. ncbi EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis
    J M Alonso
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Science 284:2148-52. 1999
    ..EIN2 is thus recognized as a molecular link between previously distinct hormone response pathways. Plants may use a combinatorial mechanism for assessing various stresses by enlisting a common set of signaling molecules...
  19. pmc NINJA connects the co-repressor TOPLESS to jasmonate signalling
    Laurens Pauwels
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, Technologiepark 927, B 9052 Gent, Belgium
    Nature 464:788-91. 2010
    ..This new insight reveals how stress-related and growth-related signalling cascades use common molecular mechanisms to regulate gene expression in plants...
  20. ncbi Cross talk between signaling pathways in pathogen defense
    Barbara N Kunkel
    Department of Biology, Washington University, Campus Box 1137, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Curr Opin Plant Biol 5:325-31. 2002
    ..The SA and JA signaling pathways are mutually antagonistic. This regulatory cross talk may have evolved to allow plants to fine-tune the induction of their defenses in response to different plant pathogens...
  21. pmc The WRKY70 transcription factor: a node of convergence for jasmonate-mediated and salicylate-mediated signals in plant defense
    Jing Li
    Department of Biosciences, Division of Genetics, University of Helsinki, FIN 00014 Helsinki, Finland
    Plant Cell 16:319-31. 2004
    ..We suggest that WRKY70 acts as an activator of SA-induced genes and a repressor of JA-responsive genes, integrating signals from these mutually antagonistic pathways...
  22. pmc The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor
    Jianbin Yan
    Department of Biological Sciences, Tsinghua University, Beijing 100084, China
    Plant Cell 21:2220-36. 2009
    ..Taken together, these results demonstrate that COI1 directly binds to JA-Ile and COR and serves as a receptor for jasmonate...
  23. ncbi (+)-7-iso-Jasmonoyl-L-isoleucine is the endogenous bioactive jasmonate
    Sandra Fonseca
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, Madrid, Spain
    Nat Chem Biol 5:344-50. 2009
    ..In addition, we show that pH changes promote conversion of (+)-7-iso-JA-L-Ile to the inactive (-)-JA-L-Ile form, thus providing a simple mechanism that can regulate hormone activity through epimerization...
  24. pmc The AP2/ERF domain transcription factor ORA59 integrates jasmonic acid and ethylene signals in plant defense
    Martial Pré
    Institute of Biology Leiden, Clusius Laboratory, Leiden University, 2333 AL Leiden, The Netherlands
    Plant Physiol 147:1347-57. 2008
    ....
  25. pmc Control of jasmonate biosynthesis and senescence by miR319 targets
    Carla Schommer
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS Biol 6:e230. 2008
    ..We propose that miR319-controlled TCP transcription factors coordinate two sequential processes in leaf development: leaf growth, which they negatively regulate, and leaf senescence, which they positively regulate...
  26. pmc Activation of the indole-3-acetic acid-amido synthetase GH3-8 suppresses expansin expression and promotes salicylate- and jasmonate-independent basal immunity in rice
    Xinhua Ding
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Cell 20:228-40. 2008
    ..Both enhanced resistance and abnormal development may be caused by inhibition of the expression of expansins via suppressed auxin signaling...
  27. pmc Silverleaf whitefly induces salicylic acid defenses and suppresses effectual jasmonic acid defenses
    Sonia I Zarate
    Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, California 92521 0124, USA
    Plant Physiol 143:866-75. 2007
    ..Collectively, these results showed that SLWF-repressed, JA-regulated defenses were associated with basal defense to the SLWF...
  28. pmc The Jasmonate-ZIM-domain proteins interact with the WD-Repeat/bHLH/MYB complexes to regulate Jasmonate-mediated anthocyanin accumulation and trichome initiation in Arabidopsis thaliana
    Tiancong Qi
    School of Life Sciences, Tsinghua University, Beijing, China
    Plant Cell 23:1795-814. 2011
    ....
  29. pmc The Jasmonate-ZIM domain proteins interact with the R2R3-MYB transcription factors MYB21 and MYB24 to affect Jasmonate-regulated stamen development in Arabidopsis
    Susheng Song
    School of Life Sciences, Tsinghua University, Beijing 100084, China
    Plant Cell 23:1000-13. 2011
    ....
  30. pmc Ethylene biosynthesis and signaling networks
    Kevin L C Wang
    Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Plant Cell 14:S131-51. 2002
  31. pmc Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis
    Ziqiang Zhu
    College of Life Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 108:12539-44. 2011
    ....
  32. pmc Conserved MYC transcription factors play a key role in jasmonate signaling both in tomato and Arabidopsis
    Marta Boter
    Departament de Genetica Molecular, Institut de Biologia Molecular de Barcelona, CID CSIC, 08034 Barcelona, Spain
    Genes Dev 18:1577-91. 2004
    ..These results show that the JAMYC/AtMYC2 transcription factors function as members of a MYC-based regulatory system conserved in dicotyledonous plants with a key role in JA-induced defense gene activation...
  33. pmc The oxylipin signal jasmonic acid is activated by an enzyme that conjugates it to isoleucine in Arabidopsis
    Paul E Staswick
    Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68583, USA
    Plant Cell 16:2117-27. 2004
    ..Plant hormone activation by conjugation to amino acids and the enzymes involved in their formation were previously unknown...
  34. ncbi Arabidopsis WRKY33 transcription factor is required for resistance to necrotrophic fungal pathogens
    Zuyu Zheng
    Department of Botany and Plant Pathology, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    Plant J 48:592-605. 2006
    ..Together, these results indicate that pathogen-induced WRKY33 is an important transcription factor that regulates the antagonistic relationship between defense pathways mediating responses to P. syringae and necrotrophic pathogens...
  35. ncbi Transcriptional machineries in jasmonate-elicited plant secondary metabolism
    Nathan De Geyter
    Department of Plant Systems Biology, VIB, Ghent University, Technologiepark 927, B 9052 Gent, Belgium
    Trends Plant Sci 17:349-59. 2012
    ..We draw parallels with the regulation of secondary metabolism in fungi and consider the remaining challenges to map and exploit the transcriptional machineries that drive JA-mediated elicitation of plant secondary metabolism...
  36. pmc The tomato homolog of CORONATINE-INSENSITIVE1 is required for the maternal control of seed maturation, jasmonate-signaled defense responses, and glandular trichome development
    Lei Li
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 16:126-43. 2004
    ..These findings indicate that the JA/COI1 signaling pathway regulates distinct developmental processes in different plants and suggest a role for JA in the promotion of glandular trichome-based defenses...
  37. pmc Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis
    Yajie Niu
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    J Exp Bot 62:2143-54. 2011
    ..2. Similar to MYC2, MYC4 negatively regulates expression of PDF1.2. Together, these results suggest that MYC3 and MYC4 are JAZ-interacting transcription factors that regulate JA responses...
  38. ncbi NPR1, all things considered
    Xinnian Dong
    Developmental, Cell and Molecular Biology Group, LSRC Building, Research Drive, Duke University, Durham, North Carolina 27708 1000, USA
    Curr Opin Plant Biol 7:547-52. 2004
    ..In addition to NPR1 and TGA, the single-stranded DNA-binding transcription factor AtWhy1 and the WRKY70 transcription factor were recently found to be involved in SA-mediated defense and SA-JA crosstalk, respectively...
  39. pmc A critical role for the TIFY motif in repression of jasmonate signaling by a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in Arabidopsis
    Hoo Sun Chung
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 21:131-45. 2009
    ..The ability of JAZ10.4 to interact with MYC2 is consistent with a model in which a JAZ10.4-containing protein complex directly represses the activity of transcription factors that promote expression of JA response genes...
  40. ncbi JAZ repressors and the orchestration of phytohormone crosstalk
    Kemal Kazan
    Commonwealth Scientific and Industrial Research Organization, Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland 4067, Australia
    Trends Plant Sci 17:22-31. 2012
    ..The emerging roles that JAZ proteins play in the regulation of diverse phytohormone signalling interactions illustrate the functional versatility of this protein family...
  41. pmc 12-oxo-phytodienoic acid triggers expression of a distinct set of genes and plays a role in wound-induced gene expression in Arabidopsis
    Nozomi Taki
    Department of Bioscience, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Plant Physiol 139:1268-83. 2005
    ..These results indicate that an OPDA signaling pathway functions independently of JA/MeJA signaling and is required for the wounding response in Arabidopsis...
  42. ncbi Molecular players regulating the jasmonate signalling network
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain
    Curr Opin Plant Biol 8:532-40. 2005
    ....
  43. ncbi Quantitative relationships between induced jasmonic acid levels and volatile emission in Zea mays during Spodoptera exigua herbivory
    Eric A Schmelz
    Center of Medical, Agricultural, and Veterinary Entomology, USDA, Agricultural Research Service, 1600 1700 Southwest 23rd Drive, Gainesville, FL 32608, USA
    Planta 216:665-73. 2003
    ..Our results strongly support a role for JA in the regulation of insect-induced volatile emission but also suggest that ethylene perception regulates the magnitude of volatile emission during herbivory...
  44. pmc Jasmonate signaling: toward an integrated view
    Kemal Kazan
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland 4067, Australia
    Plant Physiol 146:1459-68. 2008
  45. ncbi Constitutive expression of ETHYLENE-RESPONSE-FACTOR1 in Arabidopsis confers resistance to several necrotrophic fungi
    Marta Berrocal-Lobo
    Laboratorio de Bioquimica y Biologia Molecular, Departamento de Biotecnología UPM, ETS Ingenieros Agronomos, 28040 Madrid, Spain
    Plant J 29:23-32. 2002
    ....
  46. pmc Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insects
    Inga Mewis
    Department of Entomology, Chemical Ecology Laboratory, Pennsylvania State University, State College, Pennsylvania 16802, USA
    Plant Physiol 138:1149-62. 2005
    ..Our results indicate that exogenous signal application and plant consumption measures may not provide useful measures of plant responses to actual insect feeding...
  47. pmc Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross talk between salicylate and jasmonate signaling
    Antonio Leon-Reyes
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Physiol 149:1797-809. 2009
    ..Our results suggest a model in which ET modulates the NPR1 dependency of SA-JA antagonism, possibly to compensate for enhanced allocation of NPR1 to function in SA-dependent activation of PR genes...
  48. ncbi OsbHLH148, a basic helix-loop-helix protein, interacts with OsJAZ proteins in a jasmonate signaling pathway leading to drought tolerance in rice
    Ju Seok Seo
    Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
    Plant J 65:907-21. 2011
    ..Thus, our study suggests that OsbHLH148 acts on an initial response of jasmonate-regulated gene expression toward drought tolerance, constituting the OsbHLH148-OsJAZ-OsCOI1 signaling module in rice...
  49. ncbi Hormone (dis)harmony moulds plant health and disease
    Murray R Grant
    School of Biosciences, University of Exeter, Exeter EX4 4QD, UK
    Science 324:750-2. 2009
    ..A better understanding of cross-talk between hormonal and defense signaling pathways should reveal new potential targets for microbial effectors that attenuate host resistance mechanisms...
  50. pmc Jasmonate and ppHsystemin regulate key Malonylation steps in the biosynthesis of 17-Hydroxygeranyllinalool Diterpene Glycosides, an abundant and effective direct defense against herbivores in Nicotiana attenuata
    Sven Heiling
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany 07745
    Plant Cell 22:273-92. 2010
    ..We propose that high concentrations of HGL-DTGs effectively defend valuable tissues against herbivores and that malonylation may play an important role in regulating the distribution and storage of HGL-DTGs in plants...
  51. pmc The wound hormone jasmonate
    Abraham J K Koo
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, United States
    Phytochemistry 70:1571-80. 2009
    ..These results provide a framework for understanding how plants recognize and respond to tissue injury...
  52. ncbi Making sense of hormone crosstalk during plant immune responses
    Steven H Spoel
    Department of Biology, P O Box 90338, Duke University, Durham, NC 27708, USA
    Cell Host Microbe 3:348-51. 2008
    ..Here we discuss the various roles that crosstalk may play in response to pathogens with different infection strategies...
  53. ncbi MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma
    Michael A Milhollen
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Blood 116:1515-23. 2010
    ..This work describes a novel mechanism of targeted NF-kappaB pathway modulation in DLBCL and provides strong rationale for clinical development of MLN4924 against NF-kappaB-dependent lymphomas...
  54. pmc Kinetics of salicylate-mediated suppression of jasmonate signaling reveal a role for redox modulation
    Annemart Koornneef
    Graduate School Experimental Plant Sciences, Institute of Environmental Biology, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Physiol 147:1358-68. 2008
    ..The glutathione biosynthesis inhibitor l-buthionine-sulfoximine strongly reduced PDF1.2 suppression by SA, suggesting that SA-mediated redox modulation plays an important role in the SA-mediated attenuation of the JA signaling pathway...
  55. pmc Repressor- and activator-type ethylene response factors functioning in jasmonate signaling and disease resistance identified via a genome-wide screen of Arabidopsis transcription factor gene expression
    Ken C McGrath
    Cooperative Research Centre for Tropical Plant Protection, University of Queensland, St Lucia, Australia
    Plant Physiol 139:949-59. 2005
    ..Our results suggest that plants coordinately express multiple repressor- and activator-type AP2/ERFs during pathogen challenge to modulate defense gene expression and disease resistance...
  56. ncbi The Arabidopsis thaliana JASMONATE INSENSITIVE 1 gene is required for suppression of salicylic acid-dependent defenses during infection by Pseudomonas syringae
    Neva Laurie-Berry
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Mol Plant Microbe Interact 19:789-800. 2006
    ..Thus, P. syringae pv. tomato DC3000 appears to utilize COR to manipulate JIN1-dependent jasmonate signaling both to suppress SA-mediated defenses and to promote symptom development...
  57. ncbi Expression profiling reveals COI1 to be a key regulator of genes involved in wound- and methyl jasmonate-induced secondary metabolism, defence, and hormone interactions
    Alessandra Devoto
    School of Biological Sciences, University of East Anglia, NR4 7TJ, Norwich, UK
    Plant Mol Biol 58:497-513. 2005
    ..These results indicate that COI1 plays a pivotal role in wound- and JA signalling...
  58. pmc A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis
    E Bell
    Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843, USA
    Proc Natl Acad Sci U S A 92:8675-9. 1995
    ..This result suggests that wound-induced JA (or some other LOX2-requiring component of the wound response pathway) is involved in the wound-induced regulation of this gene...
  59. pmc General detoxification and stress responses are mediated by oxidized lipids through TGA transcription factors in Arabidopsis
    Stefan Mueller
    Julius von Sachs Institut fuer Biowissenschaften, Pharmazeutische Biologie, Biozentrum, Universitaet Wuerzburg, 97082 Wuerzburg, Germany
    Plant Cell 20:768-85. 2008
    ..Hence, oxidized lipids may activate chemosensory mechanisms of a general broad-spectrum detoxification network involving TGA transcription factors...
  60. pmc Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1
    Jin Long Qiu
    Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark
    Plant Physiol 148:212-22. 2008
    ..In addition, transcriptome analyses delineate overlapping and specific effects of the kinases on global gene expression patterns demonstrating both redundant and unique functions for MKK1 and MKK2...
  61. pmc Airborne signals prime plants against insect herbivore attack
    Juergen Engelberth
    Center for Medical, Agricultural, and Veterinary Entomology, U S Department of Agriculture Agricultural Research Service, 1700 SW 23rd Drive, Gainesville, FL 32608, USA
    Proc Natl Acad Sci U S A 101:1781-5. 2004
    ..Thus, GLV specifically prime neighboring plants against impending herbivory by enhancing inducible chemical defense responses triggered during attack and may play a key role in plant-plant signaling and plant-insect interactions...
  62. pmc The jasmonate pathway mediates salt tolerance in grapevines
    Ahmed Ismail
    Karlsruhe Institute of Technology, Karlsruhe, Germany
    J Exp Bot 63:2127-39. 2012
    ..The data are discussed in terms of a model where salt stress signalling acts as a default pathway whose readout is modulated by a parallel signal chain triggered by biotic factors downstream of jasmonate signalling...
  63. pmc Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade
    Dong Lei Yang
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Proc Natl Acad Sci U S A 109:E1192-200. 2012
    ..Thus, a molecular cascade involving the COI1-JAZ-DELLA-PIF signaling module, by which angiosperm plants prioritize JA-mediated defense over growth, has been elucidated...
  64. pmc Arabidopsis ASA1 is important for jasmonate-mediated regulation of auxin biosynthesis and transport during lateral root formation
    Jiaqiang Sun
    State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Cell 21:1495-511. 2009
    ....
  65. ncbi Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ
    James E Brownell
    Discovery, Millennium Pharmaceuticals, Inc, 40 Landsdowne Street, Cambridge, MA 02139, USA
    Mol Cell 37:102-11. 2010
    ..These findings reveal insights into the mechanism of E1s and suggest a general strategy for selective inhibition of UBL conjugation pathways...
  66. ncbi Enzymes in jasmonate biosynthesis - structure, function, regulation
    Andreas Schaller
    Institute of Plant Physiology and Biotechnology, University of Hohenheim, D 70599 Stuttgart, Germany
    Phytochemistry 70:1532-8. 2009
    ..Recent insights into the structure, function, and regulation of the enzymes involved in jasmonate biosynthesis help to explain how this variety is generated while specificity is maintained...
  67. ncbi Herbivore-associated elicitors: FAC signaling and metabolism
    Gustavo Bonaventure
    Max Planck Institute for Chemical Ecology, Department of Molecular Ecology, Hans Knoell Str 8, D 07745 Jena, Germany
    Trends Plant Sci 16:294-9. 2011
    ..The interaction between Nicotiana attenuata and the specialist lepidopteran Manduca sexta presents a relevant biological system to understand HAE perception and signal transduction systems in plants...
  68. pmc Regulation and function of Arabidopsis JASMONATE ZIM-domain genes in response to wounding and herbivory
    Hoo Sun Chung
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Plant Physiol 146:952-64. 2008
    ..Our results also indicate that the timing of JA-induced transcription in response to wounding is more rapid than previously realized...
  69. ncbi Arabidopsis lox3 lox4 double mutants are male sterile and defective in global proliferative arrest
    Daniela Caldelari
    Department of Biology, Duke University, Durham, North Carolina, USA
    Plant Mol Biol 75:25-33. 2011
    ..Our studies of lox3 lox4 as well as other jasmonic acid biosynthesis and perception mutants show that this plant hormone is not only required for male fertility but also involved in global proliferative arrest...
  70. ncbi Systemin/Jasmonate-mediated systemic defense signaling in tomato
    Jia qiang Sun
    State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Beijing 100101, China
    Mol Plant 4:607-15. 2011
    ..Further understanding of the systemin/JA signaling pathway promises to provide new insights into the basic mechanisms governing plant defense to biotic stress...
  71. pmc DONGLE and DEFECTIVE IN ANTHER DEHISCENCE1 lipases are not essential for wound- and pathogen-induced jasmonate biosynthesis: redundant lipases contribute to jasmonate formation
    Dorothea Ellinger
    Department of Plant Physiology, Ruhr Universitat, 44801 Bochum, Germany
    Plant Physiol 153:114-27. 2010
    ....
  72. pmc Efficacy and safety of intravenous peramivir for treatment of seasonal influenza virus infection
    Shigeru Kohno
    2nd Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    Antimicrob Agents Chemother 54:4568-74. 2010
    ..Peramivir was well tolerated, and its adverse-event profile was similar to that of placebo. A single intravenous dose of peramivir is effective and well tolerated in subjects with uncomplicated seasonal influenza virus infection...
  73. ncbi Antisense LOX expression increases herbivore performance by decreasing defense responses and inhibiting growth-related transcriptional reorganization in Nicotiana attenuata
    Rayko Halitschke
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans Knöll Str 8, D 07745 Jena, Germany
    Plant J 36:794-807. 2003
    ..By genetically manipulating signaling in a plant with a well-characterized ecology, we demonstrate that the complex phenotypic changes that mediate herbivore resistance are controlled by a specific part of the oxylipin cascade...
  74. ncbi Towards global understanding of plant defence against aphids--timing and dynamics of early Arabidopsis defence responses to cabbage aphid (Brevicoryne brassicae) attack
    Anna Kusnierczyk
    Department of Biology, The Norwegian University of Science and Technology, Realfagbygget, 7491 Trondheim, Norway
    Plant Cell Environ 31:1097-115. 2008
    ..brassicae was reduced on camalexin-accumulating wild-type (WT) plants as compared with camalexin-deficient pad3-1 mutants. Based on experimental data, a model of plant-aphid interactions at the early phase of infestation was proposed...
  75. ncbi The jasmonate pathway: the ligand, the receptor and the core signalling module
    Sandra Fonseca
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain
    Curr Opin Plant Biol 12:539-47. 2009
    ..Small changes in jasmonate structure result in hormone inactivation and might be the key to switching-off signalling for specific responses to stimulus and for long-distance signalling events...
  76. pmc Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis
    Kohki Yoshimoto
    RIKEN, Plant Science Center, Tsurumi ku, Yokohama, Japan
    Plant Cell 21:2914-27. 2009
    ..We also show that autophagy is induced by the SA agonist. These findings imply that plant autophagy operates a novel negative feedback loop modulating SA signaling to negatively regulate senescence and immunity-related PCD...
  77. pmc The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis
    Linghui Xu
    Institute of Biotechnology Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    Plant Cell 14:1919-35. 2002
    ..These results suggest that the COI1-mediated JA response is dependent on the SCF(COI1) complexes in Arabidopsis and that the AXR1-dependent modification of the AtCUL1 subunit of SCF(COI1) complexes is important for JA signaling...
  78. pmc NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol
    Steven H Spoel
    Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Plant Cell 15:760-70. 2003
    ....
  79. ncbi OsWRKY13 mediates rice disease resistance by regulating defense-related genes in salicylate- and jasmonate-dependent signaling
    Deyun Qiu
    National Key Laboratory of Crop Genetic Improvement, National Center for Plant Gene Research, Huazhong Agricultural University, Wuhan 430070, China
    Mol Plant Microbe Interact 20:492-9. 2007
    ..Furthermore, OsWRKY13 will provide a transgenic tool for engineering wider-spectrum and whole-growth-stage resistance rice in breeding programs...
  80. pmc Oviposition by pierid butterflies triggers defense responses in Arabidopsis
    Dawn Little
    Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland
    Plant Physiol 143:784-800. 2007
    ..This study provides molecular evidence for the detection of egg deposition by Arabidopsis plants and suggests that oviposition causes a localized response with strong similarity to a hypersensitive response...
  81. ncbi A conditionally fertile coi1 allele indicates cross-talk between plant hormone signalling pathways in Arabidopsis thaliana seeds and young seedlings
    Christine Ellis
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Planta 215:549-56. 2002
    ..We have used coi1-16 seeds to define novel interactions between JA and other hormone signalling pathways in seed germination and in the development of young seedlings...
  82. ncbi Interplay of signaling pathways in plant disease resistance
    B J Feys
    Sainsbury Laboratory, John Innes Centre, Colney Lane, NR4 7UH, Norwich, UK
    Trends Genet 16:449-55. 2000
    ..The interplay of signals probably allows the plant to fine-tune defense responses in both local and systemic tissue...
  83. ncbi Long-distance signalling in plant defence
    Martin Heil
    Dpto de Ingeniería Genética, CINVESTAV Irapuato, Km 9 6 Libramiento Norte, CP 36821, Irapuato, Guanajuato, Mexico
    Trends Plant Sci 13:264-72. 2008
    ..We compare the advantages and constraints of vascular and airborne signals for the plant, and discuss how they can act in synergy to achieve optimised resistance in distal plant parts...
  84. pmc NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells
    Jie Jessie Lin
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Cancer Res 70:10310-20. 2010
    ..Furthermore, our findings show that transient exposure to this new investigational drug should be useful for controlling p53-negative cancer cells, which often pose significant clinical challenge...
  85. pmc Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression
    Lijun Jia
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B Medical Science I, Ann Arbor, MI 48109, USA
    Neoplasia 13:561-9. 2011
    ..Our study reveals a novel mechanism of MLN4924 action and showed that MLN4924 could be further developed as an effective anticancer agent by inducing apoptosis and irreversible senescence...
  86. ncbi Arabidopsis thaliana class-II TGA transcription factors are essential activators of jasmonic acid/ethylene-induced defense responses
    Mark Zander
    Albrecht von Haller Institut fuer Pflanzenwissenschaften, Georg August Universitaet Goettingen, Untere Karspuele 2, D 37073 Goettingen, Germany
    Plant J 61:200-10. 2010
    ..These results imply that the antagonistic effects of TGA factors and JIN1/AtMYC2 on the JA/ET pathway are necessary to evoke the SA-mediated suppression of JA/ET-induced defense responses...
  87. ncbi Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid
    Naoki Saito
    Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Plant Cell Physiol 49:1396-401. 2008
    ..These results suggest that RCN1 functions upstream of ROS production and downstream of the branch point of MeJA signaling and ABA signaling in Arabidopsis guard cells...
  88. pmc Molecular interactions between the specialist herbivore Manduca sexta (Lepidoptera, Sphingidae) and its natural host Nicotiana attenuata. III. Fatty acid-amino acid conjugates in herbivore oral secretions are necessary and sufficient for herbivore-specifi
    R Halitschke
    Department of Molecular Ecology, Max Planck Institut for Chemical Ecology, Carl Zeiss Promenade 10, D-07745 Jena, Germany
    Plant Physiol 125:711-7. 2001
    ....
  89. ncbi Co(i)-ordinating defenses: NaCOI1 mediates herbivore- induced resistance in Nicotiana attenuata and reveals the role of herbivore movement in avoiding defenses
    Anja Paschold
    Max Planck Institute for Chemical Ecology, Department of Molecular Ecology, Hans Knoll Strasse 8, 07745 Jena, Germany
    Plant J 51:79-91. 2007
    ..We conclude that NaCOI1 is essential for induced resistance in N. attenuata, and that ir-coi1 plants highlight the benefits of herbivore movement for avoiding induced defenses...
  90. ncbi Cytosolic alkalization and cytosolic calcium oscillation in Arabidopsis guard cells response to ABA and MeJA
    Mohammad Mahbub Islam
    Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Plant Cell Physiol 51:1721-30. 2010
    ..These results indicate that cytosolic alkalization and cytosolic Ca(2+) oscillation coordinately function in ABA and MeJA signaling in Arabidopsis guard cells...
  91. ncbi Transcriptional responses of Arabidopsis thaliana ecotypes with different glucosinolate profiles after attack by polyphagous Myzus persicae and oligophagous Brevicoryne brassicae
    Anna Kusnierczyk
    Department of Biology, The Norwegian University of Science and Technology, Realfagbygget, 7491, Trondheim, Norway
    J Exp Bot 58:2537-52. 2007
    ..persicae. Targeted studies employing constructs of GUS reporter gene under the control of promoters from CYP79B2 and CYP79B3 genes showed insect-specific induction of the indole glucosinolates synthesis pathway...
  92. pmc Jasmonate signaling: a conserved mechanism of hormone sensing
    Leron Katsir
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Curr Opin Plant Biol 11:428-35. 2008
    ....
  93. pmc Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3203, USA
    Clin Infect Dis 50:1252-5. 2010
    ..We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir...
  94. pmc Plant defense in the absence of jasmonic acid: the role of cyclopentenones
    A Stintzi
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, USA
    Proc Natl Acad Sci U S A 98:12837-42. 2001
    ..More generally, resistance to insect and fungal attack can be observed in the absence of JA...
  95. pmc Whiteflies interfere with indirect plant defense against spider mites in Lima bean
    Peng Jun Zhang
    Laboratory of Entomology, Wageningen University, PO Box 8031, 6700 EH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 106:21202-7. 2009
    ..We therefore conclude that in dual-infested Lima bean plants the suppression of the JA signaling pathway by whitefly feeding is not due to enhanced SA levels...
  96. ncbi Jasmonates: structural requirements for lipid-derived signals active in plant stress responses and development
    Claus Wasternack
    Department of Natural Product Biotechnology, Leibniz Institute of Plant Biochemistry, Weinberg 3, Halle Saale, Germany
    ACS Chem Biol 5:63-77. 2010
    ..For key enzymes of JA biosynthesis the crystal structures have been established, allowing insight into the mechanisms of catalysis and modes of substrate binding that lead to formation of stereospecific products...
  97. pmc A pair of allelic WRKY genes play opposite roles in rice-bacteria interactions
    Zeng Tao
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Physiol 151:936-48. 2009
    ..The opposite roles of the two allelic genes in rice-Xoo interaction appear to be due to their mediation of different defense signaling pathways...
  98. ncbi Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis
    Yuko Sasaki-Sekimoto
    Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Yokohama, Kanagawa, 226 8501, Japan
    Plant J 44:653-68. 2005
    ..Compared with the wild type, opr3 mutants were more sensitive to O3 exposure. These results suggest that the coordinated activation of the metabolic pathways mediated by jasmonates provides resistance to environmental stresses...
  99. ncbi Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses
    Jennifer L Nemhauser
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 126:467-75. 2006
    ..Instead, different hormones appear to regulate distinct members of protein families. We conclude that there is not a core transcriptional growth-regulatory module in young Arabidopsis seedlings...
  100. pmc The jasmonate signal pathway
    John G Turner
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Plant Cell 14:S153-64. 2002
  101. pmc Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure
    Dontamala Suhita
    CEA Cadarache DSV DEVM, Laboratoire des Echanges Membranaires et Signalisation, UMR 163 CNRS CEA, Universite de la Mediterranee, 13108 St Paul lez Durance Cedex, France
    Plant Physiol 134:1536-45. 2004
    ..Our results further indicate that JAR1, as OST1, functions upstream of ROS produced by NAD(P)H oxidases and that the cytoplasmic alkalization precedes ROS production during MJ or ABA signal transduction in guard cells...

Research Grants62

  1. SYNTHETIC/MECHANISTIC STUDIES OF BIOACTIVE MARINE AGENTS
    Daniel Romo; Fiscal Year: 2013
    ..The end results of these studies will be identification of further useful biochemical tools and potential leads for drug development as demonstrated with pateamine A. ..
  2. Asymmetric Synthesis of Bioactive Natural Products Using Nazarov Cyclization
    ALISON J FRONTIER; Fiscal Year: 2013
    ..Ultimately, goals include the identification of new antiviral agents and a better understanding of the behavior of lipoxygenase inhibitors. ..
  3. NEW CHEMICAL APPROACHES TO ADP-RIBOSYL TRANSFER
    James Slama; Fiscal Year: 1991
    ..The "transition-state analogue" will be tested as an inhibitor of NAD- glycohydrolase and the microbial toxins...
  4. Synthesis of Bioactive Complex Alkaloids
    David Y Gin; Fiscal Year: 2010
    ..as well as other convergent cycloaddition strategies for the construction of fully substituted all-cis cyclopentanes. Successful synthesis of these target molecules will not only lay the foundation of efficient and practical ..
  5. STRUCTURE ACTIVITY RELATIONSHIPS IN CADPR
    Steven Graham; Fiscal Year: 2001
    ..g. glycosidic torsion angles) and the extent of transmission of stereoelectronic effects between sugars, backbone and adenine base can be revealed. ..
  6. Allylsilane Annulation Strategy for Diversity Synthesis
    ANNALIESE FRANZ; Fiscal Year: 2004
    ..Examples of cancer-relevant phenotypic screens include inhibition of cell division, motor protein inhibition, cell cycle progression, and inhibition of apoptosis. ..
  7. FUSED POLYCYCLIC AMINES VIA DOUBLE ANNULATION
    Robert Grossman; Fiscal Year: 2004
    ..The yohimbine and corynanthine analogs will be tested for alpha-adrenoceptor antagonist activity. ..
  8. BIOSYNTHESIS AND METABOLISM OF CYCLOPENTANOIDS
    Ronald Parry; Fiscal Year: 2001
    ..The potential use of the CmaA gene for construction of hybrid peptide antibiotics containing L-alloisoleucine or coronamic acid will also be explored, using surfactin biosynthesis in B. subtilis as a model system. ..
  9. Purchase of a 700MHz NMR Spectrometer for Liquid Applications
    John Montgomery; Fiscal Year: 2009
    ..stereocenters, determination of relative stereochemistry of 5-membered carbocyclic ring systems such as cyclopentanes, tetrahydrofurans, and pyrrolidines possessing up to 4 stereocenters, characterization of unstable organoboron ..
  10. CHARACTERIZATION OF THE LUNG PGDH
    Richard Okita; Fiscal Year: 1991
    ....
  11. ACTIVATION OF ARACHIDONATE METABOLISM
    ALAN BRASH; Fiscal Year: 1992
    ..an 8- hydroperoxide product, to an unstable allene oxide intermediate, and then to prostaglandins and related cyclopentanes. Lipoxygenase metabolism of cellular esters...
  12. PALLADIUM CATALYZED CYCLIZATION OF FUNCTIONALIZED DIENES
    ROSS WIDENHOEFER; Fiscal Year: 2003
    ..Realization of these goals would produce a powerful tool for the synthesis of naturally occurring and pharmacologically active carbocycles and heterocycles. ..
  13. STUDIES OF POLYHYDROXYCYCLOALKANES
    HENRY SABLE; Fiscal Year: 1980
    ..The ongoing study of the cyclopentane-1,2,3-triol monophosphates as substrates for alpha-glycerophosphate dehydrogenase will be continued...
  14. INTRAMOLECULAR CYCLIZATIONS OF CYCLODECENES
    James White; Fiscal Year: 1990
    ..Several other strategies, including one that involves transannular radical cyclization of an oxygen-stabilized radical center and another that makes use of a variant of an anion accelerated Cope rearrangement, will also be investigated...
  15. Synthetic Approach to the Elisapterosins and Cumbiasins
    Matthew Weiss; Fiscal Year: 2002
    ..abstract_text> ..
  16. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  17. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  18. MEMBRANE FUNCTION IN MUTANTS OF CAENORHABDITIS ELEGANS
    John Browse; Fiscal Year: 2004
    ..Quantitative measures of low-temperature performance and thermotolerance of the range of desaturase mutants will be correlated with fatty acid composition and measurements of membrane fluidity. ..
  19. Allenic [2 + 2 + 1] Reactions Enabling Syntheses of Natural Products with 7-Membe
    Kay M Brummond; Fiscal Year: 2010
    ..Grayanotoxin is an important molecular tool for deciphering the mechanism for gating functions of the sodium ion channels. ..
  20. New Methods for the Synthesis of Neurological Agents
    LARRY OVERMAN; Fiscal Year: 2008
    ..oryzae at 90 nM, suggesting potential antitumor activity. Because of the scarcity of these natural products from their natural sources, little biological evaluation has been carried out. ..
  21. PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDS
    LARRY OVERMAN; Fiscal Year: 2009
    ....
  22. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  23. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  24. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  25. A role for circadian clock genes in hippocampal function?
    Christopher Colwell; Fiscal Year: 2008
    ..This line of research has not been previously funded, is exploratory in nature, and thus qualifies under the R21 format. [unreadable] [unreadable] [unreadable]..
  26. Neuromodulatory Effects of Ginkgolides and Bilobalide
    Koji Nakanishi; Fiscal Year: 2007
    ..These studies can potentially provide new targets for terpene trilactones in the central nervous system that require the synthesis of new ginkgolide and bilobalide ligands. [unreadable] [unreadable]..
  27. Perinatal hypoxia-ischemia, glutamate receptors, and Nitric Oxide Synthase
    Zhengwei Cai; Fiscal Year: 2007
    ..Direct effects of inflammatory cytokines and IGF-1 on survival and differentiation of OLs will be examined in cultures of OLs at various maturation stages. ..
  28. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  29. Alkynyliodonium Salts and Derived Diyls in Synthesis
    Ken Feldman; Fiscal Year: 2009
    ..abstract_text> ..
  30. Asymmetric Synthesis of Amino Acids and Amino Phosphonic Acids
    FRANKLIN DAVIS; Fiscal Year: 2007
    ..The photodesulfmylation of sulfinamides represents an important new protocol, not requiring acids or bases, for the removal of the valuable amine N-sulfinyl protecting group. ..
  31. New Methodology for Indole Alkaloid Syntheses
    Ken S Feldman; Fiscal Year: 2010
    ..The use of a new variant of the Pummerer reaction to control both oxidation level and reaction site within the indole nucleus forms the basis of this chemistry. ..
  32. SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS
    BARRY SNIDER; Fiscal Year: 2009
    ..In the course of these studies new methods will be developed that are of general utility for preparing drugs more economically. ..
  33. NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTION
    Frank Carroll; Fiscal Year: 2008
    ..abstract_text> ..
  34. Connexin acetylation: Impact on gap junction function and HDAC inhibitor respons
    JEANNETTE CHLOE BULINSKI; Fiscal Year: 2010
    ..In a broader view, we will also demonstrate novel roles by which protein acetylation regulates cellular functions not directly involved with gene expression. ..
  35. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
    ..Daphnicyclidin A. This recent discovery has revealed a new molecular architecture which exhibits significant antitumor activity. Our research will investigate strategies for chemical synthesis of these complex polycyclic systems. ..
  36. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
    ..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
  37. NOVEL PHARMACOTHERAPIES FOR COCAINE DEPENDENCE
    Frank Carroll; Fiscal Year: 2001
    ..An ideal candidate compound would not only have efficacy in the preclinical models but would be safe, orally active, and potent, would not show tolerance or sensitization, and if abusable, would be less so than cocaine. ..
  38. Therapeutics for Pox, Filo and Other Viral Pathogens
    STEWART SCHNELLER; Fiscal Year: 2007
    ..Because of the extensive collaborations that have been ongoing for some time by this group of chemists and virologists, it can be expected that promising anti-orthopoxvirus and anti-filovirus agents will be uncovered. ..
  39. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  40. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
    ....
  41. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  42. SYNTHESIS OF DIAZONAMIDES
    Philip Magnus; Fiscal Year: 2004
    ..Part of the synthetic studies will involve the generation of persistent radical intermediates that should add to pi-deficient heterocycles and form the key central hindered bond present in the diazonamides. ..
  43. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  44. MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONE
    Ercole Cavalieri; Fiscal Year: 2003
    ..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
  45. NEW SYNTHESIS OF BIOCHEMICALS WITH HOMOGENEOUS CATALYSTS
    Iwao Ojima; Fiscal Year: 2003
    ..In this project, we plan to develop new synthetic routes to a variety of enantiopure heterocyclic and carbocyclic compounds of medicinal interest featuring diastereoselective or enantioselective catalytic processes as the key steps. ..
  46. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2002
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..
  47. PATHOPHYSIOLOGICAL ROLE OF 12-R-LIPOXYGENASE
    ALAN BRASH; Fiscal Year: 2002
    ..abstract_text> ..
  48. Molecular Orgin Cancer--Catechol Estrogen 3 4 Quinones
    Ercole Cavalieri; Fiscal Year: 2004
    ..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
  49. STUDIES OF NATURAL PRODUCTS BY CHIROPTICAL METHODS
    Koji Nakanishi; Fiscal Year: 2004
    ..This will include CD studies of retinal/opsin in rhodopsin and retinal/bacterioopsin in bacteriorhodopsin. Vinca alkaloid/tubulin and taxoid/tubulin complexes will be analyzed by FDCD. ..
  50. SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENT
    Paul Wender; Fiscal Year: 2005
    ..Overall, this research program is expected to be of significant value in chemistry, biology, and medicine. ..
  51. METHODOLOGY FOR THE SYNTHESIS OF NITROGEN HETEROCYCLES
    Philip Magnus; Fiscal Year: 2007
    ..The synthetic intermediates, particularly as they more closely resemble the natural products, will be screened to assess biological activity. [unreadable] [unreadable]..
  52. INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 2006
    ..The selective synthesis of contiguous stereotriads will advance basic methodology for asymmetric conjugate additions. ..
  53. ASYMMETRIC SYNTHESIS OF BIOACTIVE PRIMARY AMINES
    FRANKLIN DAVIS; Fiscal Year: 2006
    ....
  54. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
    ..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..
  55. Individual Predoctoral Dental Scientist Fellowship
    Hessam Siavash; Fiscal Year: 2006
    ....
  56. Retinal Inputs to the Mammalian Circadian Pacemaker
    KWOON WONG; Fiscal Year: 2006
    ..These experiments may enable a better understanding of how the mammalian circadian pacemaker is regulated, which in turn may lead to better therapies and workplace policies combating/preventing jet lag problems. ..
  57. STUDIES ON RHODOPSIN & AGE-RELATED MACULAR DEGENERATION
    Koji Nakanishi; Fiscal Year: 2006
    ..abstract_text> ..
  58. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  59. Chemical and Biological Studies on Biaryl Phenolics
    Ken Feldman; Fiscal Year: 2005
    ..The search for selective 20S proteosome inhibitors among the Ntn-type proteases will be advanced by these investigations. ..
  60. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..