fludrocortisone

Summary

Summary: A synthetic mineralocorticoid with anti-inflammatory activity.

Top Publications

  1. ncbi [Prerenal kidney failure in type 1 diabetes mellitus]
    N C Schloot
    Deutsche Diabetes Klinik, Deutsches Diabetes Forschungsinstitut, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 128:2588-90. 2003
  2. ncbi Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
    Kerrie L Schoffer
    Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, and Department of Medicine, University of Queensland, Australia
    Mov Disord 22:1543-9. 2007
  3. pmc Her tongue tipped us off
    Chantelle Barnard
    Division of Pediatric Medicine, Department of Pediatrics, University of Toronto Faculty of Medicine and the Hospital for Sick Children, Toronto, Ont
    CMAJ 171:451. 2004
  4. ncbi Impact of availability of oral hydrocortisone on growth of children with CAH
    V V Khadilkar
    Jehangir Hospital, Deenanath Mangeshkar Hospital, Pune and Bombay Hospital, Bombay, India
    Indian J Pediatr 72:301-3. 2005
  5. ncbi Fludrocortisone in patients with familial dysautonomia--assessing effect on clinical parameters and gene expression
    Felicia B Axelrod
    Dept of Pediatrics, New York University School of Medicine, New York, NY, USA
    Clin Auton Res 15:284-91. 2005
  6. ncbi Urinary acidification assessed by simultaneous furosemide and fludrocortisone treatment: an alternative to ammonium chloride
    S B Walsh
    Department of Physiology and Centre for Nephrology, Royal Free and University College Medical School, London, UK
    Kidney Int 71:1310-6. 2007
  7. ncbi Adverse cardiac effects of salt with fludrocortisone in hypertension
    P O Lim
    Hypertension Research Center, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Hypertension 37:856-61. 2001
  8. ncbi Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate
    S C Djajadiningrat-Laanen
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Vet Intern Med 22:1283-8. 2008
  9. ncbi Fludrocortisone therapy in cerebral salt wasting
    Craig E Taplin
    The Children s Hospital at Westmead, Institute of Endocrinology and Diabetes, Locked Bag 4001, Westmead 2145, New South Wales, Australia
    Pediatrics 118:e1904-8. 2006
  10. ncbi Effectiveness of fludrocortisone and salt in preventing syncope recurrence in children: a double-blind, placebo-controlled, randomized trial
    Mubadda A Salim
    Division of Pediatric Cardiology, Department of Pediatrics, The University of Tennessee, Memphis, USA
    J Am Coll Cardiol 45:484-8. 2005

Research Grants

  1. HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSION
    Alan Schatzberg; Fiscal Year: 2009
  2. DIABETIC AUTONOMIC NEUROPATHY
    Phillip Low; Fiscal Year: 2001
  3. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
  4. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
  5. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
  6. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
  7. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
  8. Otitis Media Impact on the Inner Ear
    Dennis Trune; Fiscal Year: 2007
  9. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
  10. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002

Detail Information

Publications223 found, 100 shown here

  1. ncbi [Prerenal kidney failure in type 1 diabetes mellitus]
    N C Schloot
    Deutsche Diabetes Klinik, Deutsches Diabetes Forschungsinstitut, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 128:2588-90. 2003
    ..For the past 3 years he suffered from repetitive hypoglycemia, combined with vertigo, weakness and low blood pressure...
  2. ncbi Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
    Kerrie L Schoffer
    Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, and Department of Medicine, University of Queensland, Australia
    Mov Disord 22:1543-9. 2007
    ..The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures...
  3. pmc Her tongue tipped us off
    Chantelle Barnard
    Division of Pediatric Medicine, Department of Pediatrics, University of Toronto Faculty of Medicine and the Hospital for Sick Children, Toronto, Ont
    CMAJ 171:451. 2004
  4. ncbi Impact of availability of oral hydrocortisone on growth of children with CAH
    V V Khadilkar
    Jehangir Hospital, Deenanath Mangeshkar Hospital, Pune and Bombay Hospital, Bombay, India
    Indian J Pediatr 72:301-3. 2005
    ..2. To compare growth parameters of patients with CAH who have been on treatment with HC since diagnosis with patients managed on PR...
  5. ncbi Fludrocortisone in patients with familial dysautonomia--assessing effect on clinical parameters and gene expression
    Felicia B Axelrod
    Dept of Pediatrics, New York University School of Medicine, New York, NY, USA
    Clin Auton Res 15:284-91. 2005
    ..Because drugs may alter splicing, seven drugs, fludrocortisone, midodrine, diazepam, albuterol, clonidine, caffeine, and dopamine were screened...
  6. ncbi Urinary acidification assessed by simultaneous furosemide and fludrocortisone treatment: an alternative to ammonium chloride
    S B Walsh
    Department of Physiology and Centre for Nephrology, Royal Free and University College Medical School, London, UK
    Kidney Int 71:1310-6. 2007
    ..was achieved by the simultaneous oral administration of the diuretic furosemide and the mineralocorticoid fludrocortisone to increase distal tubular sodium delivery, principal cell sodium reabsorption, and alpha-intercalated cell ..
  7. ncbi Adverse cardiac effects of salt with fludrocortisone in hypertension
    P O Lim
    Hypertension Research Center, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Hypertension 37:856-61. 2001
    ..We assessed the effect of salt with fludrocortisone on QT dispersion and echocardiographic left ventricular diastolic function in a prospective interventional ..
  8. ncbi Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate
    S C Djajadiningrat-Laanen
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Vet Intern Med 22:1283-8. 2008
    ..The endocrine diagnosis of primary hyperaldosteronism in cats currently is based on an increased plasma aldosterone to renin ratio, which has several disadvantages for use in veterinary practice...
  9. ncbi Fludrocortisone therapy in cerebral salt wasting
    Craig E Taplin
    The Children s Hospital at Westmead, Institute of Endocrinology and Diabetes, Locked Bag 4001, Westmead 2145, New South Wales, Australia
    Pediatrics 118:e1904-8. 2006
    ..Diagnosis can be difficult and therapy challenging. A few single case reports of the successful use of fludrocortisone exist...
  10. ncbi Effectiveness of fludrocortisone and salt in preventing syncope recurrence in children: a double-blind, placebo-controlled, randomized trial
    Mubadda A Salim
    Division of Pediatric Cardiology, Department of Pediatrics, The University of Tennessee, Memphis, USA
    J Am Coll Cardiol 45:484-8. 2005
    We sought to evaluate the effectiveness of salt and fludrocortisone versus placebo in the prevention of syncope recurrence in children.
  11. ncbi A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome
    P K Peterson
    Department of Medicine, Hennepin County Medical Center, Minneapolis, Minn 55415, USA
    Arch Intern Med 158:908-14. 1998
    To provide a preliminary assessment of the efficacy and safety of fludrocortisone acetate treatment of chronic fatigue syndrome.
  12. ncbi Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 Blvd Raymond Poincaré, 92380 Garches, France
    JAMA 288:862-71. 2002
    ..Septic shock may be associated with relative adrenal insufficiency. Thus, a replacement therapy of low doses of corticosteroids has been proposed to treat septic shock...
  13. ncbi Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure
    J J van Lieshout
    Cardiovascular Research Institute Amsterdam, Department of Internal Medicine, Academic Medical Centre, The Netherlands
    Clin Auton Res 10:35-42. 2000
    Treatment with head-up tilt sleeping and low-dose fludrocortisone effectively minimizes orthostatic symptoms and increases orthostatic blood pressure in patients with neurogenic orthostatic hypotension...
  14. ncbi Fludrocortisone treatment in a child with severe cerebral salt wasting
    S T Kinik
    Pediatric Endocrinology Unit, Hacettepe University Faculty of Medicine, Ihsan Dogramaci Children s Hospital, Ankara, Turkey
    Pediatr Neurosurg 35:216-9. 2001
    ..Despite intensive fluid and salt therapy, we were unable to decrease the urinary output. Therefore, fludrocortisone therapy was administered and his urinary output and sodium excretion were decreased and his serum sodium ..
  15. doi Successful treatment of adult cerebral salt wasting with fludrocortisone
    Peter Lee
    Arch Intern Med 168:325-6. 2008
  16. ncbi The treatment of cerebral salt wasting with fludrocortisone in a child with lissencephaly
    Halil Ozdemir
    Ankara Diskapi Pediatric Disease Education and Investigation Hospital, Pediatric Intensive Care Unit, Ankara, Turkey
    Turk Neurosurg 20:100-2. 2010
    ..The patient was treated with hypertonic saline and multiple antiepileptic drugs. Fludrocortisone supplementation effectively treated cerebral salt wasting.
  17. ncbi Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome: a randomized controlled trial
    P C Rowe
    Departments of Pediatrics and Medicine, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    JAMA 285:52-9. 2001
    ..OBJECTIVE: To examine the efficacy of fludrocortisone acetate as monotherapy for adults with both CFS and NMH...
  18. ncbi Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fludrocortisone
    J Freitas
    Centro de Estudos da Função Autonómica do Hospital de São João do Porto, Portugal
    Clin Auton Res 10:293-9. 2000
    ..the autonomic and hemodynamic profile of patients with POTS and the effectiveness of bisoprolol and fludrocortisone. The authors evaluated 11 female patients with POTS before and after medical treatment with a cardioselective ..
  19. ncbi Cerebral salt wasting in a patient with head trauma: management with saline hydration and fludrocortisone
    Akram Askar
    Department of Medicine, Division of Nephrology King Khalid University Hospital, Riyadh, Saudi Arabia
    Saudi J Kidney Dis Transpl 18:95-9. 2007
    ..Improvements in serum sodium levels after saline hydration and fludrocortisone administration further supported the diagnosis, even in the presence of normal brain and atrial natriuretic ..
  20. ncbi [Addison's disease as a rare cause of chronically elevated liver enzymes]
    G C Gurakuqi
    Medizinische Universitatsklinik, Klinische Abteilung für Gastroenterologie und Hepatologie, Medizinische Universitat Graz
    Z Gastroenterol 44:179-83. 2006
    ..In conclusion, for patients with constantly elevated liver enzymes also rare, extrahepatic diseases have to be considered. Addison's disease is a rare but fully reversible cause for elevated liver enzymes...
  21. ncbi Potassium-lowering effect of mineralocorticoid therapy in patients undergoing hemodialysis
    Ryuichi Furuya
    Kidney Center, Iwata City Hospital, Iwata, Japan
    Nephron 92:576-81. 2002
    The present study was conducted to examine potassium lowering effect of exogenous mineralocorticoid (fludrocortisone acetate; FCA) administration to the patients with chronic renal failure undergoing hemodialysis...
  22. ncbi Blood pressure in children and adolescents with congenital adrenal hyperplasia (21-hydroxylase deficiency): a preliminary report
    Edna F Roche
    Centre for Human Growth and Maturation, London Centre for Paediatric Endocrinology, University College London, UK
    Clin Endocrinol (Oxf) 58:589-96. 2003
    ..The latter along with the increased tendency towards obesity raises questions whether other cardiovascular risk factors are altered in CAH...
  23. ncbi Addison's disease
    Lynnette K Nieman
    Reproductive and Biology Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Dermatol 24:276-80. 2006
    ..Synthetic adrenocorticotropin 1-24 at a dose of 250 microg works well as a dynamic test. Elevated plasma levels of adrenocorticotropin and renin confirm the diagnosis. Treatment involves replacement of the deficient hormones...
  24. ncbi [Sun-tanned and still not healthy!]
    D Spörri
    Pädiatrische Endokrinologie, Diabetologie and Metabolik, Medizinische Universitats Kinderklinik, Inselspital, Universitatsspital Bern
    Praxis (Bern 1994) 95:1135-9. 2006
    ..A therapy of mineralcorticoids and glucocorticoids was initiated and a special gluten-free diet was prescribed. On this treatment our patient recovered promptly...
  25. pmc Congenital adrenal hypoplasia presenting as a chronic respiratory condition
    K Schwarz
    Paediatric Department, Bradford Royal Informary, UK
    Arch Dis Child 88:261-2. 2003
    ..Respiratory symptoms resolve very quickly when the underlying condition is recognised and treated...
  26. ncbi Corticosteroids and the cardiovascular response to stress: a pilot study of the 35% CO2 challenge in Addison's disease
    J M Kaye
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Bristol, UK
    Clin Endocrinol (Oxf) 65:282-6. 2006
    ..In this pilot study, a clinical model of primary adrenocortical failure (Addison's disease, AD) has been used to evaluate the role of circulating glucocorticoids in both the autonomic and psychological response to stress...
  27. ncbi Chronic fatigue syndrome and Addison's disease
    Riccardo Baschetti
    J Pediatr 142:217; author reply 217-8. 2003
  28. ncbi Management of adrenal insufficiency in different clinical settings
    Stefanie Hahner
    Department of Endocrinology, University of Wuerzburg, Josef Schneider Str 2, D 97080 Wuerzburg, Germany
    Expert Opin Pharmacother 6:2407-17. 2005
    ..b>Fludrocortisone 0.05-0...
  29. ncbi Fludrocortisone does not prevent orthostatic hypotension in astronauts after spaceflight
    Shang Jin Shi
    Wyle Laboratories, Houston, TX, USA
    Aviat Space Environ Med 75:235-9. 2004
    ..Spaceflight-induced hypovolemia is a contributing factor. Fludrocortisone, a synthetic mineralocorticoid, has been shown to increase plasma volume and orthostatic tolerance in Earth-..
  30. ncbi Behavioral and physical masculinization are related to genotype in girls with congenital adrenal hyperplasia
    Catherine M Hall
    Royal Manchester Children s Hospital, Manchester M27 4HA, United Kingdom
    J Clin Endocrinol Metab 89:419-24. 2004
    ..Both physical and behavioral masculinization were related to each other and to genotype, indicating that behavioral masculinization is a consequence of prenatal androgen exposure...
  31. ncbi Mineralocorticoid and glucocorticoid receptors and their differential effects on memory performance in people with Addison's disease
    Michelle Y Tytherleigh
    Department of Experimental Psychology, University of Bristol, Clifton, UK
    Psychoneuroendocrinology 29:712-23. 2004
    ..01). Whilst significant effects were not consistent across memory tasks, these results lend further support to the view that balanced activation of MRs and GRs is necessary for optimal memory function in humans...
  32. ncbi Reversible cardiomyopathy in paediatric Addison's disease--a cautionary tale
    L S Conwell
    Department of Endocrinology and Diabetes Royal Children s Hospital, Brisbane, Queensland, Australia
    J Pediatr Endocrinol Metab 16:1191-5. 2003
    ..Large doses of i.v. hydrocortisone and oral fludrocortisone, in addition to inotropic and ventilatory support, were required to achieve cardiovascular stability...
  33. ncbi Sexual dimorphism in the synchrony of joint growth hormone and cortisol dynamics in children with classic 21-hydroxylase deficiency
    E Charmandari
    London Centre for Paediatric Endocrinology, University College London, London, UK
    J Pediatr Endocrinol Metab 16:1119-30. 2003
    ..83 +/- 0.20) (p = 0.03). These findings suggest that females with classic 21-hydroxylase deficiency have a more irregular pattern of GH secretion and a more asynchronous joint GH and cortisol dynamics than their male counterparts...
  34. ncbi Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Gerontol A Biol Sci Med Sci 58:B900-5. 2003
    ..5 mg of the MR agonist fludrocortisone or placebo...
  35. ncbi [Anti-inflammatory therapy in sepsis]
    J Briegel
    Chirurg 74:590-1; author reply 591-2. 2003
  36. ncbi The mineralocorticoid receptor agonist, fludrocortisone, inhibits pituitary-adrenal activity in humans after pre-treatment with metyrapone
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Life Sci 73:1835-45. 2003
    ..5 mg fludrocortisone p.o. or 0.2 mg aldosterone i.v. or placebo...
  37. ncbi Combination therapy with hydrocortisone and fludrocortisone does not improve symptoms in chronic fatigue syndrome: a randomized, placebo-controlled, double-blind, crossover study
    Daniel Blockmans
    Department of General Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Med 114:736-41. 2003
    ..fatigue syndrome than in controls, attempts to alleviate symptoms by administration of hydrocortisone or fludrocortisone have not been successful...
  38. ncbi Effect of mineralocorticoids on interdialytic weight gain in hemodialysis patients with perdialytic hypotension
    Lucile Mercadal
    Hopital Pitie Salpetriere, 83 bd de l hopital, Paris, France
    Hemodial Int 9:338-40. 2005
    b>Fludrocortisone is recommended in patients with orthostatic hypotension and a benefit has been suggested in hemodialysis patients with severe hypokaliemia...
  39. ncbi Corticosteroid insufficiency in acutely ill patients
    Roxanna Bloomfield
    N Engl J Med 348:2157-9. 2003
  40. pmc Longitudinal analysis of growth and puberty in 21-hydroxylase deficiency patients
    H J Van der Kamp
    Department of Paediatrics, Leiden University Medical Center, Leiden, Netherlands
    Arch Dis Child 87:139-44. 2002
    ..To evaluate growth from diagnosis until final height (FH) in 21-hydroxylase deficiency patients...
  41. ncbi Dangers of liquid drug preparations
    Joanne J Spinks
    J Pediatr Endocrinol Metab 20:1249. 2007
  42. ncbi Living with congenital adrenal hyperplasia in Vietnam: a survey of parents
    K L Armstrong
    Goulburn Valley Health, Shepparton, Vic, Australia
    J Pediatr Endocrinol Metab 19:1207-23. 2006
    ..It is hoped that this information will be used to ensure that future efforts to reduce the burden of CAH are as effective, sustainable and appropriate as possible...
  43. ncbi Low-dose steroid therapy does not affect hemodynamic response in septic shock patients
    Joan M Raurich
    Servicio de Medicina Intensiva, Hospital Universitario Son Dureta, 07014 Palma de Mallorca, Spain
    J Crit Care 22:324-9. 2007
    ..However, these results have been criticized. Our purpose was to evaluate the effects of LDST on time to shock reversal and mortality in septic shock...
  44. ncbi Current pharmacologic treatment for orthostatic hypotension
    Roy Freeman
    Dept of Neurology Harvard Medical School, Center for Autonomic and Peripheral Nerve Disorders Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Clin Auton Res 18:14-8. 2008
    ..If unsuccessful there are several supplementary agents with different mechanisms of action that may provide an additive effect...
  45. ncbi Hydrocortisone suspension and hydrocortisone tablets are not bioequivalent in the treatment of children with congenital adrenal hyperplasia
    D P Merke
    Warren Grant Magnuson Clinical Center, Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    J Clin Endocrinol Metab 86:441-5. 2001
    ..Nineteen children receiving Cortef and fludrocortisone therapy were changed to hydrocortisone tablets and fludrocortisone, with a 10 percent reduction in ..
  46. ncbi Testicular adrenal rest tumours in salt wasting congenital adrenal hyperplasia (in vivo and in vitro studies)
    Jean Pierre Bercovici
    Department of Endocrinology, Université de Bretagne Occidentale UBO, 29200 Brest, France
    J Steroid Biochem Mol Biol 93:67-72. 2005
    ..The results revealed the testicular tumours were of adrenal tissue origin, associated with 21-hydroxylase deficiency. The patient's non-compliance to glucocorticoid treatment was the main cause of his hypogonadotropic hypogonadism...
  47. ncbi [Primary adrenal insufficiency/Addison disease]
    Urania Kolyvanos Naumann
    Klinik und Poliklinik für Innere Medizin, Universitatsspital Zurich
    Praxis (Bern 1994) 97:4-10; quiz 11-2. 2008
  48. ncbi Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study
    Stella Douma
    Second Propedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Greece
    Lancet 371:1921-6. 2008
    ..We aimed to assess the prevalence of primary hyperaldosteronism in a large group of patients with resistant hypertension...
  49. ncbi Patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency can achieve their target height: the Leipzig experience
    Wolfgang Hoepffner
    University Children s Hospital, Leipzig, Germany
    Horm Res 70:42-50. 2008
    ..Despite treatment, the mean final height (FH) of patients with classic congenital adrenal hyperplasia (CAH) is below the mean height of a normal population...
  50. pmc Appendicectomy complicated by Addisons disease
    Michael J Mullan
    Ulster Med J 77:58-9. 2008
  51. ncbi [Increasing pigmentation in Schmidt syndrome (polyglandular autoimmune syndrome type II]
    S Sünkel
    Ludwig Maximilians Universität München Klinikum Innenstadt, Medizinische Klinik, Endokrinologische Ambulanz
    Hautarzt 52:974-6. 2001
    ..After another 18 months of treatment with hormone substitution of L-thyroxine and hydrocortisone, the hyperpigmentation resolved and the hyperpigmented nevi decreased in number...
  52. ncbi Adrenal tuberculosis after a pheochromocytoma: a misleading tumoral presentation
    S Hieronimus
    Services d endocrinologie médecine de la reproduction, Hopital L Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Ann Endocrinol (Paris) 68:191-5. 2007
    ..It stresses the importance of culture of biopsy tumor, whenever feasible, to avoid unnecessary operations. In the near future, interferon-gamma assay could be a valuable means to recognize extrapulmonary forms of tuberculosis...
  53. ncbi Postprandial hypotension treated with acarbose in a patient with type 1 diabetes mellitus
    Simona Maule
    Clin Auton Res 14:405-7. 2004
    ..We report a case of a type 1 diabetic patient suffering from severely symptomatic PPH. The patient was treated with acarbose and showed definite improvement of both glycemic control and PPH...
  54. ncbi Hyperkalaemia and selective hypoaldosteronism in myotonic dystrophy
    Dolly Misra
    Department of Medicine, Section of Endocrinology, VAMC, Washington, DC, USA
    Clin Endocrinol (Oxf) 56:271-5. 2002
    ..The treatment of all cases with fludrocortisone was without effect...
  55. ncbi Steroids in sepsis--more effective than activated protein C?
    C Bradley
    St George s Hospital, London, UK
    Intensive Crit Care Nurs 17:242-4. 2001
    ....
  56. ncbi Orthostatic hypotension in the elderly: diagnosis and treatment
    Vishal Gupta
    Beth Israel Deaconess Medical Center, Hebrew SeniorLife, and Harvard Medical School, Boston, Mass 02131, USA
    Am J Med 120:841-7. 2007
    ..and the patient remains persistently symptomatic, various pharmacotherapeutic agents can be added, including fludrocortisone, midodrine, and nonsteroidal anti-inflammatory drugs...
  57. ncbi [19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)]
    C Lipowsky
    Fachbereich für Endokrinologie und Diabetologie, Departement fur Innere Medizin, Kantonsspital St Gallen
    Praxis (Bern 1994) 97:77-81. 2008
    ..Thus, in case of doubt hydrocortisone should be given before the thyroxine administration is started...
  58. pmc Diagnosis--Addison's disease secondary to tuberculosis of the adrenal glands
    Mrinal M Patnaik
    Department of Internal Medicine, University of Minnesota, Minneapolis, MN 55414, USA
    Clin Med Res 6:29. 2008
  59. ncbi [Adrenal insufficiency caused by treatment with levothyroxine]
    L Rey
    , Centre Hospitalier Universitaire Vaudois, Lausanne
    Praxis (Bern 1994) 90:2103-8. 2001
    ..This clinical case is discussed in details with a special emphasis to the published literature regarding the strategy of diagnosis and the specific therapy of primary adrenal insufficiency...
  60. ncbi Addison's disease, diffuse skin, and mucosal hyperpigmenation with subtle "flu-like" symptoms--a report of two cases
    Cynthia J Burk
    Department of Dermatology and Cutaneous Surgery, Division of Pediatric Dermatology, University of Miami, Miller School of Medicine, Miami, Florida, USA
    Pediatr Dermatol 25:215-8. 2008
    ....
  61. ncbi Flutamide decreases cortisol clearance in patients with congenital adrenal hyperplasia
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, 10 Center Drive, Building 10 Suite 9D42, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 87:3197-200. 2002
    ..A new four-drug treatment regimen of flutamide, testolactone, reduced hydrocortisone dose, and 9alpha-fludrocortisone has been shown to achieve normal growth and development after 2 yr of therapy and may, therefore, represent a ..
  62. ncbi Midodrine: insidious development of urologic adverse effects in patients with spinal cord injury: a report of 2 cases
    Subramanian Vaidyanathan
    Regional Spinal Injuries Centre, District General Hospital, Southport, United Kingdom
    Adv Ther 24:712-20. 2007
    ..For postural hypotension, he was prescribed midodrine (5 mg in the morning and 2.5 mg at lunchtime), fludrocortisone (100 microg daily), and ephedrine (15 mg by mouth, taken 10 min before getting up in the morning)...
  63. ncbi A preliminary study of flutamide, testolactone, and reduced hydrocortisone dose in the treatment of congenital adrenal hyperplasia
    L Laue
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 81:3535-9. 1996
    ..cross-over open design to determine whether flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone are more effective than hydrocortisone and fludrocortisone treatment in normalizing linear growth, weight ..
  64. ncbi The use of oral vasopressors in the management of autonomic dysfunction and orthostatic hypotension
    E T Wittbrodt
    Clinical Pharmacy, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19104, USA
    Ann Pharmacother 33:565-71. 1999
    ..To describe a patient with hypotension secondary to autonomic dysfunction who was successfully treated with oral vasopressors...
  65. ncbi Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: alterations in cortisol pharmacokinetics at puberty
    E Charmandari
    London Centre for Paediatric Endocrinology, University College London, United Kingdom W1N 8AA
    J Clin Endocrinol Metab 86:2701-8. 2001
    ..All patients were on standard replacement therapy with hydrocortisone and 9 alpha-fludrocortisone. Serum total cortisol concentrations were measured at 10-min intervals for 6 h following iv hydrocortisone ..
  66. ncbi [Orthostatic hypotension and supine hypertension in pure autonomic failure]
    Michelangelo Sartori
    Clinica Medica 4, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi, Padova
    Ital Heart J Suppl 5:879-83. 2004
    ..Salt-retaining steroid fludrocortisone, also, used to treat orthostatic hypotension, increases blood pressure both in supine and in standing ..
  67. ncbi Hyperaldosteronism: the internist's hypertensive disease
    C Andrew Brown
    Department of Medicine, The University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Med Sci 324:227-31. 2002
    ..urinary aldosterone excretion on a high-salt diet, aldosterone suppression after a saline infusion, and the fludrocortisone suppression test, which is considered the most sensitive confirmatory maneuver...
  68. ncbi Flutamide, testolactone, and reduced hydrocortisone dose maintain normal growth velocity and bone maturation despite elevated androgen levels in children with congenital adrenal hyperplasia
    D P Merke
    Warren Grant Magnuson Clinical Center, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda Maryland 20892 1862, USA
    J Clin Endocrinol Metab 85:1114-20. 2000
    ..flutamide), an inhibitor of androgen to estrogen conversion (testolactone), reduced hydrocortisone dose, and fludrocortisone, compared to the effects of a control regimen of hydrocortisone and fludrocortisone...
  69. ncbi Preliminary experience with midodrine in kidney/pancreas transplant patients with orthostatic hypotension
    G C Hurst
    Ochsner Multi Organ Transplant Center, New Orleans, LA 70121, USA
    Clin Transplant 14:42-7. 2000
    ..of maximizing the patient's hydration, altering antihypertensives, increasing sodium intake, initiation of fludrocortisone, compression stockings, and behavioral modifications...
  70. ncbi Midodrine. A review of its therapeutic use in the management of orthostatic hypotension
    K J McClellan
    Adis International Limited, Auckland, New Zealand
    Drugs Aging 12:76-86. 1998
    ..studies have shown midodrine to have similar efficacy to dihydroergotamine mesylate, norfenefrine, fludrocortisone and etilefrine, and to be more effective than dimetofrine and ephedrine in patients with orthostatic ..
  71. ncbi Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management
    J M Senard
    Laboratory of Medical and Clinical Pharmacology, INSERM U317, Faculty of Medicine, Paul Sabatier University, Toulouse, France
    Drugs Aging 18:495-505. 2001
    ..Among the available drugs, alpha1-adrenergic agonists (mainly midodrine) or plasma volume expanders (mainly fludrocortisone) are the most frequently used...
  72. ncbi Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy
    Christopher H Gibbons
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Arch Neurol 65:213-7. 2008
    ..Symptomatic and immunomodulatory therapy has provided limited clinical benefit in small uncontrolled studies...
  73. ncbi Validation of a solid-phase extraction and ultra-performance liquid chromatographic tandem mass spectrometric method for the detection of 16 glucocorticoids in pig tissues
    Bing Shao
    Beijing Center for Disease Control and Prevention, Beijing 100013, People s Republic of China
    J AOAC Int 92:604-11. 2009
    ..hydrocortisone, prednisone, dexamethasone, beclomethasone, prednisolone, budesonide, triamcinolone acetonide, fludrocortisone acetate, and cortisone) residues in pig tissues (muscle, liver, and kidney)...
  74. ncbi Treatment of dysautonomia associated with Parkinson's disease
    Giovanni Mostile
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Parkinsonism Relat Disord 15:S224-32. 2009
    ..Orthostatic hypotension: fludrocortisone, midodrine, and droxidopa; 2. Sialorrhea: glycopyrrolate and botulinun toxin injections; 3...
  75. ncbi Prolonged hyperkalemia following unilateral adrenalectomy for primary hyperaldosteronism
    W T Huang
    Department of Internal Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan, R O C
    Clin Nephrol 73:392-7. 2010
    ..b>Fludrocortisone 0...
  76. ncbi Use of aromatase inhibitors in precocious puberty
    P Feuillan
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Relat Cancer 6:303-6. 1999
    ..adrenal hyperplasia, testolactone, in combination with an antiandrogen (flutamide), a mineralocorticoid (fludrocortisone acetate, Florinef), and a reduced glucocorticoid dose, improved the control of growth and bone maturation ..
  77. ncbi Metformin-responsive classic salt-losing congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a case report
    Ann Celeste Mapas-Dimaya
    Department of Pediatrics, Woodhull Medical Center, Brooklyn, Brooklyn, NY 11206, USA
    Endocr Pract 14:889-91. 2008
    ..To study the effect of adding metformin to standard steroid replacement therapy in a patient with classic salt-losing congenital adrenal hyperplasia due to 21-hydroxylase deficiency with suboptimal biochemical and clinical control...
  78. ncbi Treatment of vasovagal syncope: an update
    Luciana Armaganijan
    Arrhythmia and Pacing Service, McMaster University HHSC PHRI, 237 Barton Street East, David Bradley CVSRI, Room C3 120, Hamilton, ON, Canada, L8L 2X2
    Curr Treat Options Cardiovasc Med 12:472-88. 2010
    ..The ongoing Second Prevention of Syncope Trial (POST II) is investigating the benefits of fludrocortisone in this population...
  79. ncbi Antipsychotic pharmacotherapy and orthostatic hypotension: identification and management
    James J Gugger
    Department of Clinical Pharmacy Practice, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, USA
    CNS Drugs 25:659-71. 2011
    ..b>Fludrocortisone is a reasonable first choice for symptomatic orthostatic hypotension...
  80. ncbi Drug treatment of orthostatic hypotension because of autonomic failure or neurocardiogenic syncope
    Maxime Lamarre-Cliche
    Hôpital Européen Georges Pompidou Centre d Investigations Cliniques, Paris, France
    Am J Cardiovasc Drugs 2:23-35. 2002
    ..b>Fludrocortisone is a well known and frequently used pressor drug but randomized controlled studies are needed to measure its ..
  81. ncbi The current management of septic shock
    J A Russel
    Critical Care Medicine, St Paul s Hospital, Vancouver, BC, Canada
    Minerva Med 99:431-58. 2008
    ..Annane et al. found that hydrocortisone plus fludrocortisone (compared to placebo) was associated with lower mortality in patients who had an inadequate response to ..
  82. ncbi A novel CYP11B2 gene mutation in an Asian family with aldosterone synthase deficiency
    Kristian Løvås
    Department of Medicine, University of Cambridge, Cambridge CB2 1TN, United Kingdom
    J Clin Endocrinol Metab 94:914-9. 2009
    Three siblings of Pakistani origin presented neonatally with isolated hyperreninemic hypoaldosteronism and were well controlled on fludrocortisone therapy during childhood and adolescence.
  83. ncbi Modulation of the mineralocorticoid receptor as add-on treatment in depression: a randomized, double-blind, placebo-controlled proof-of-concept study
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Germany
    J Psychiatr Res 44:339-46. 2010
    ..We tested in a proof-of-concept study whether adding fludrocortisone (an MR agonist) or spironolactone (an MR antagonist) accelerates onset of action and improves efficacy of ..
  84. ncbi An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency
    Hedi L Claahsen-van der Grinten
    Department of Paediatric Endocrinology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Endocrinol 159:489-91. 2008
    ..Here, we report on an adult patient with CAH due to 3beta-hydroxysteroid dehydrogenase (HSD) deficiency with bilateral TART and additionally a large perirenal adrenal rest tumour...
  85. ncbi Rare causes of acute hyperkalemia in the 1st week of life. Three case reports
    Vasilios I Giapros
    Neonatal Intensive Care Unit, Medical School, University of Ioannina, Ioannina, Greece
    Pediatr Nephrol 19:1046-9. 2004
    ..The two infants with selective HA improved rapidly after administration of fludrocortisone orally and the electrolytes and renin values returned to normal...
  86. ncbi Dementia in Parkinson's disease
    Avrom L Kurtz
    Department of Neurology, CB 7025, The University of North Carolina at Chapel Hill, 3129 Physician Office Building, Chapel Hill, NC, 27599, USA
    Curr Treat Options Neurol 13:242-54. 2011
    ..Orthostatic hypotension can be managed with various nonpharmacologic interventions, and if needed, fludrocortisone and pyridostigmine. Midodrine should be used cautiously, if at all.
  87. ncbi Endocrine complications associated with human immunodeficiency virus infection
    J V Etzel
    College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439
    Clin Pharm 11:705-13. 1992
    ..Administration of fludrocortisone can rapidly alleviate the signs and symptoms of hyporeninemic hypoaldosteronism...
  88. ncbi [Metabolic assessment of hydrocortisone replacement therapy in patients with primary adrenocortical insufficiency]
    Marta Fichna
    Klinika Endokrynologii, Przemiany Materii i Chorób Wewnetrznych, Uniwersytet Medyczny im K Marcinkowskiego w Poznaniu
    Przegl Lek 68:96-102. 2011
    ..6 years. All patients were supplemented with hydrocortisone (10-60 mg/day), 45 also used fludrocortisone, and 8 - dehydroepiandrosterone...
  89. ncbi Usefulness of a tilt training program for the prevention of refractory neurocardiogenic syncope in adolescents: A controlled study
    E Di Girolamo
    Cardiosurgical Department, Cardiologic Division, C C U SS Annunziata Hospital, School of Cardiology G D Annunzio University, Chieti, Italy
    Circulation 100:1798-801. 1999
    ..Although the administration of beta-blockers, vasoconstrictors, fludrocortisone, and serotonin reuptake inhibitors may be helpful in preventing episodes, many patients are intolerant of or ..
  90. ncbi Novel germline SDHD mutation: diagnosis and implications to the patient
    Jeena Varghese
    Departments of Endocrine Neoplasia and Hormonal Disorders, Unit 1461, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Fam Cancer 10:365-71. 2011
    ..His blood pressure normalized and he discontinued antihypertensive medications after surgery. He is currently on replacement therapy with hydrocortisone and fludrocortisone.
  91. ncbi Growth patterns in the first three years of life in children with classical congenital adrenal hyperplasia diagnosed by newborn screening and treated with low doses of hydrocortisone
    W Bonfig
    Pediatric Endocrinology, Dr von Haunersches Kinderspital, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Horm Res Paediatr 75:32-7. 2011
    ..Linear growth is the best clinical parameter for monitoring metabolic control in classical congenital adrenal hyperplasia (CAH)...
  92. ncbi [Pyridostigmine in the treatment of primary orthostatic hypotension]
    J A Monge Argiles
    Servicio de Neurologia, Hospital General Universitario, Alicante
    Neurologia 22:260-2. 2007
    ..It has recently been reported that pyridostigmine is useful in neurogenic orthostatic hypotension...
  93. ncbi [Growth rate of children with congenital adrenal hyperplasia during treatment with low doses of hydrocortisone]
    Ivani Novato Silva
    Divisão de Endocrinologia Infantil e do Adolescente, Departamento de Pediatria, Hospital de Clinicas, Faculdade de Medicina, UFMG, Belo Horizonte, MG
    Arq Bras Endocrinol Metabol 49:120-5. 2005
    ..1 +/- 1.8 years with daily hydrocortisone doses of 10.84 +/- 2.0 mg/m2 and 0.1 mg fludrocortisone (24 of them). Twenty-three were female. Mean chronological age (CA) was 6.1 +/- 2.9 years and bone age (BA) 6...
  94. ncbi Hydrocortisone effects on cardiovascular variability in septic shock: a spectral analysis approach
    Jerome Aboab
    Réanimation Polyvalente, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin, Garches, France
    Crit Care Med 36:1481-6. 2008
    ..Septic shock may be associated with a loss in cardiovascular variability and adrenal dysfunction...
  95. pmc Role of steroids in septic shock: Assessment of knowledge, attitudes and practices among intensivists practising in Hyderabad
    Deven Juneja
    Department of Anesthesia and Critical Care Medicine, Global Hospital, Lakdi ka pul, Hyderabad 04, India
    Indian J Crit Care Med 13:143-7. 2009
    ..There was no agreement regarding the dose of steroids, the role of fludrocortisone and whether steroids should be tapered...
  96. ncbi A 31-year-old woman with infertility and polycystic ovaries diagnosed with non-classic congenital adrenal hyperplasia due to a novel CYP21 mutation
    H Falhammar
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
    J Endocrinol Invest 31:176-80. 2008
    ..In spite of treatment with dexamethasone and fludrocortisone in doses that suppressed adrenal androgens and 17-OHP into normal range or below, she did not ovulate...
  97. ncbi Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry
    Martina M Erichsen
    Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
    J Clin Endocrinol Metab 94:4882-90. 2009
    ..We aimed to determine the clinical, immunological, and genetic features of a national registry-based cohort...
  98. ncbi Disseminated cryptococcosis causes adrenal insufficiency in an immunocompetent individual
    Zui Sheng Hung
    Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Intern Med 49:1023-6. 2010
    ..The patient is currently on a therapeutic regimen of prednisolone, fludrocortisone and fluconazole and is scheduled for regular outpatient follow-up.
  99. ncbi Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep, and chicken
    Dongmei Chen
    National Reference Laboratory of Veterinary Drug Residues HZAU MAO Key Laboratory of Food Safety Evaluation, Huazhong Agricultural University, Wuhan 430070, P R China
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:1363-71. 2010
    ..prednisolone, hydrocortisone, methylprednisolone, dexamethasone, betamethasone, beclomethasone, and fludrocortisone) in the muscles and livers of swine, cattle, and sheep and the muscle of chicken is described...
  100. pmc Spontaneous puberty in 46,XX subjects with congenital lipoid adrenal hyperplasia. Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic acute regulatory protein (StAR) gene
    K Fujieda
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    J Clin Invest 99:1265-71. 1997
    ..These patients responded to treatment with glucocorticoid and 9alpha-fludrocortisone. Spontaneous thelarche occurred in association with increased serum estradiol levels at the age of 10 and 11 ..
  101. ncbi A clinical, physiology and pharmacology evaluation of orthostatic hypotension in the elderly
    Manish Sahni
    Malcolm Randall VA Medical Center, GRECC, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Int Urol Nephrol 37:669-74. 2005
    ..After these methods, pharmacological treatment with fludrocortisone and midodrine should be tried...

Research Grants27

  1. HPA AXIS/DOPAMINE INTERACTIONS IN PSYCHOTIC DEPRESSION
    Alan Schatzberg; Fiscal Year: 2009
    ..In depressed patients, smaller hippocampi are associated with decreased MR responses on fludrocortisone challenge;(3) 8 days of treatment with 600mg/day of mifepristone results in significantly greater improvement ..
  2. DIABETIC AUTONOMIC NEUROPATHY
    Phillip Low; Fiscal Year: 2001
    ..Treatment of diabetic orthostatic hypotension with alpha-agonists or fludrocortisone cause or aggravate supine hypertension...
  3. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  5. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  6. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  7. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  8. Otitis Media Impact on the Inner Ear
    Dennis Trune; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  10. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  11. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  12. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
  13. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  14. Radioactive Iodide Therapy of Pediatric Graves' Disease
    Scott A Rivkees; Fiscal Year: 2010
    ....
  15. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
  16. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  17. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  18. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  19. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  20. Autonomic Nervous System in Chronic Fatigue Syndrome
    Italo Biaggioni; Fiscal Year: 2009
    ....
  21. Detecting Med Errors in Rural Hospitals Using Technology
    C Brown; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  22. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
    ....
  23. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
    ..These studies will be directly applicable to the evaluation and treatment of patients with these incapacitating disorders. ..
  24. T Wave Alternans and Repolarization Abnormalities
    Daniel Bloomfield; Fiscal Year: 2003
    ....
  25. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..