Genomes and Genes
Summary: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Publications386 found, 100 shown here
- Vitamin D deficiencyMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
N Engl J Med 357:266-81. 2007
- Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guidelineMichael F Holick
Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 96:1911-30. 2011The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency.
- A pooled analysis of vitamin D dose requirements for fracture preventionHeike A Bischoff-Ferrari
Center on Aging and Mobility, University of Zurich and Waid City Hospital, Zurich, Switzerland
N Engl J Med 367:40-9. 2012The results of meta-analyses examining the relationship between vitamin D supplementation and fracture reduction have been inconsistent.
- A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolutionSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
Genome Res 20:1352-60. 2010Initially thought to play a restricted role in calcium homeostasis, the pleiotropic actions of vitamin D in biology and their clinical significance are only now becoming apparent...
- The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to knowA Catharine Ross
Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Clin Endocrinol Metab 96:53-8. 2011This article summarizes the new 2011 report on dietary requirements for calcium and vitamin D from the Institute of Medicine (IOM)...
- The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysisAnastassios G Pittas
Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
J Clin Endocrinol Metab 92:2017-29. 2007Altered vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes mellitus (type 2 DM)...
- Vitamin D-binding protein and vitamin D status of black Americans and white AmericansCamille E Powe
From the Department of Medicine, Brigham and Women s Hospital C E P, Division of Nephrology, Massachusetts General Hospital J W, H T, I B, R T, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School A H B, Division of Nephrology, Beth Israel Deaconess Medical Center D Z, S A K, and Howard Hughes Medical Institute D Z, S A K all in Boston the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore M K E, A B Z the Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD M N and the Department of Medicine, San Francisco General Hospital and University of California, San Francisco, San Francisco N R P
N Engl J Med 369:1991-2000. 2013Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency.
- Hypovitaminosis D is associated with insulin resistance and beta cell dysfunctionKen C Chiu
Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California Los Angeles School of Medicine, 924 Westwood Boulevard, Los Angeles, CA 90024, USA
Am J Clin Nutr 79:820-5. 2004Although the role of vitamin D in type 2 diabetes is well recognized, its relation to glucose metabolism is not well studied.
- The nonskeletal effects of vitamin D: an Endocrine Society scientific statementClifford J Rosen
Tufts University School of Medicine, Boston, MA 02111, USA
Endocr Rev 33:456-92. 2012Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues...
- Intake of vitamin D and risk of type 1 diabetes: a birth-cohort studyE Hypponen
Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, WC1N 1EH, London, UK
Lancet 358:1500-3. 2001Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes.
- 25-hydroxyvitamin D levels and the risk of mortality in the general populationMichal L Melamed
Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 615, Bronx, NY 10461, USA
Arch Intern Med 168:1629-37. 2008In patients undergoing dialysis, therapy with calcitriol or paricalcitol or other vitamin D agents is associated with reduced mortality...
- Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosisMichael F Holick
Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
Am J Clin Nutr 79:362-71. 2004The purpose of this review is to put into perspective the many health benefits of vitamin D and the role of vitamin D deficiency in increasing the risk of many common and serious diseases, including some common cancers, type 1 diabetes, ..
- 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective studyEdward Giovannucci
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 168:1174-80. 2008b>Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans.
- Vitamin D and type 2 diabetes: a systematic reviewJ Mitri
Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA
Eur J Clin Nutr 65:1005-15. 2011b>Vitamin D may modify the risk of type 2 diabetes mellitus. The aim of this review was to examine the association between vitamin D status and incident type 2 diabetes, and the effect of vitamin D supplementation on glycemic outcomes.
- Overview of general physiologic features and functions of vitamin DHector F DeLuca
Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
Am J Clin Nutr 80:1689S-96S. 2004..This overview provides a brief description of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D. It also provides information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy.
- MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosyPhilip T Liu
Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California, USA
Nat Med 18:267-73. 2012..as indirectly upregulating interleukin-10 (IL-10), hsa-mir-21 inhibited expression of the genes encoding two vitamin D-dependent antimicrobial peptides, CAMP and DEFB4A. Conversely, knockdown of hsa-mir-21 in M...
- Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysisMark J Bolland
Department of Medicine, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand
BMJ 342:d2040. 2011..the effects of personal calcium supplement use on cardiovascular risk in the Women's Health Initiative Calcium/Vitamin D Supplementation Study (WHI CaD Study), using the WHI dataset, and to update the recent meta-analysis of calcium ..
- Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trialJoan M Lappe
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Am J Clin Nutr 85:1586-91. 2007Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking.
- Prevention of rickets and vitamin D deficiency in infants, children, and adolescentsCarol L Wagner
American College of Obstetrics and Gynecology
Pediatrics 122:1142-52. 2008Rickets in infants attributable to inadequate vitamin D intake and decreased exposure to sunlight continues to be reported in the United States. There are also concerns for vitamin D deficiency in older children and adolescents...
- 25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studiesPeter Brøndum-Jacobsen
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
Arterioscler Thromb Vasc Biol 32:2794-802. 2012..We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death...
- Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney diseaseORLANDO M GUTIERREZ
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Circulation 119:2545-52. 2009..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
- Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1Yong Zhang
Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
J Immunol 188:2127-35. 2012It is estimated that 1 billion people around the world are vitamin D deficient. Vitamin D deficiency has been linked to various inflammatory diseases...
- Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysisP S George
Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Diabet Med 29:e142-50. 2012To systematically review the evidence for the effect of vitamin D supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes.
- High prevalence of vitamin D inadequacy and implications for healthMichael F Holick
Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
Mayo Clin Proc 81:353-73. 2006During the past decade, major advances have been made in vitamin D research that transcend the simple concept that vitamin D is Important for the prevention of rickets in children and has little physiologic relevance for adults...
- Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implicationsP Lips
Department of Endocrinology, Institute for Endocrinology, Reproduction and Metabolism, EVM Institute, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
Endocr Rev 22:477-501. 2001b>Vitamin D deficiency is common in the elderly, especially in the housebound and in geriatric patients. The establishment of strict diagnostic criteria is hampered by differences in assay methods for 25-hydroxyvitamin D...
- Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trialsPhilippe Autier
International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
Arch Intern Med 167:1730-7. 2007Ecological and observational studies suggest that low vitamin D status could be associated with higher mortality from life-threatening conditions including cancer, cardiovascular disease, and diabetes mellitus that account for 60% to 70% ..
- Systematic review: Vitamin D and cardiometabolic outcomesAnastassios G Pittas
Tufts Medical Center and Friedman School of Nutrition Science and Policy, and Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Ann Intern Med 152:307-14. 2010b>Vitamin D may modify risk for cardiometabolic outcomes (type 2 diabetes, hypertension, or cardiovascular disease).
- Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding geneWim Janssens
Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
Thorax 65:215-20. 2010b>Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD).
- Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination SurveyDavid Martins
Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
Arch Intern Med 167:1159-65. 2007Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D.
- Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortalityHarald Dobnig
Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
Arch Intern Med 168:1340-9. 2008..This study aimed to determine whether endogenous 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels are related to all-cause and cardiovascular mortality...
- Prognostic effects of 25-hydroxyvitamin D levels in early breast cancerPamela J Goodwin
Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X4, Canada
J Clin Oncol 27:3757-63. 2009b>Vitamin D has been linked to breast cancer risk, but prognostic effects are unknown...
- Vitamin D deficiency in obese children and its relationship to glucose homeostasisMicah L Olson
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
J Clin Endocrinol Metab 97:279-85. 2012The aim of the study was to compare the prevalence of vitamin D deficiency in obese and non-overweight children in North Texas, to examine relationships between dietary habits and 25-hydroxyvitamin D [25(OH)D] level in obese children, ..
- Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysisLaura Tripkovic
Department of Nutrition and Metabolism, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Am J Clin Nutr 95:1357-64. 2012..Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D]...
- Antibacterial effects of vitamin DMartin Hewison
Department of Orthopaedic Surgery, Room 410D, Orthopaedic Hospital Research Center, 615 Charles E Young Drive South, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Nat Rev Endocrinol 7:337-45. 2011Interaction between vitamin D and the immune system has been recognized for many years, but its relevance to normal human physiology has only become evident in the past 5 years...
- Dose response to vitamin D supplementation in postmenopausal women: a randomized trialJ Christopher Gallagher
Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
Ann Intern Med 156:425-37. 2012Serum 25-hydroxyvitamin D (25-[OH]D) is considered the best biomarker of clinical vitamin D status.
- Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatmentAnna K Coussens
Division of Mycobacterial Research, Medical Research Council National Institute for Medical Research, London, United Kingdom
Proc Natl Acad Sci U S A 109:15449-54. 2012Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic antimicrobial responses in vitro...
- Concentrations of serum vitamin D and the metabolic syndrome among U.S. adultsEarl S Ford
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341, USA
Diabetes Care 28:1228-30. 2005
- Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trialsLars Rejnmark
Dr Med Sc, AssociateAarhus University, Department of Endocrinology and Internal Medicine, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
J Clin Endocrinol Metab 97:2670-81. 2012b>Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected...
- A single dose of vitamin D enhances immunity to mycobacteriaAdrian R Martineau
Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, and Department of Clinical Biochemistry, North West London Hospitals NHS Trust, Northwick Park Hospital, Harrow, E1 2AT, UK
Am J Respir Crit Care Med 176:208-13. 2007b>Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity have not previously been performed.
- Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectivenessBruce W Hollis
Division of Neonatology and Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA
J Bone Miner Res 26:2341-57. 2011The need, safety, and effectiveness of vitamin D supplementation during pregnancy remain controversial...
- Is vitamin D deficiency to blame for the asthma epidemic?Augusto A Litonjua
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Allergy Clin Immunol 120:1031-5. 2007..prosperous, more time is spent indoors, and there is less exposure to sunlight, leading to decreased cutaneous vitamin D production...
- Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination SurveyAdit A Ginde
Emergency Medicine Network, Massachusetts General Hospital, 326 Cambridge Street, Boston, MA 02114, USA
Arch Intern Med 169:384-90. 2009Recent studies suggest a role for vitamin D in innate immunity, including the prevention of respiratory tract infections (RTIs)...
- Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney diseaseA Levin
Department of Nephrology, University of British Columbia, Vancouver, BC, Canada
Kidney Int 71:31-8. 2007..Blood for parathyroid hormone (PTH), vitamin D metabolites, creatinine, calcium (Ca), and phosphorus (P) were drawn between June and October 2004...
- Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination SurveyRobert Scragg
School of Population Health, University of Auckland, Private Bag, Auckland, New Zealand
Diabetes Care 27:2813-8. 2004..To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity...
- Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000Nita G Forouhi
Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
Diabetes 57:2619-25. 2008..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
- Resurrection of vitamin D deficiency and ricketsMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, and Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA
J Clin Invest 116:2062-72. 2006The epidemic scourge of rickets in the 19th century was caused by vitamin D deficiency due to inadequate sun exposure and resulted in growth retardation, muscle weakness, skeletal deformities, hypocalcemia, tetany, and seizures...
- Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetesSakineh Shab-bidar
Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Diabetes Metab Res Rev 28:424-30. 2012Both vitamin D deficiency and inflammation have been linked to cardiovascular disease, the major cause of death in diabetes...
- Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humansIbhar Al Mheid
Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Am Coll Cardiol 58:186-92. 2011The primary objective of this study was to elucidate mechanisms underlying the link between vitamin D status and cardiovascular disease by exploring the relationship between 25-hydroxyvitamin D (25-OH D), an established marker of vitamin ..
- Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studiesArmin Zittermann
Clinic for Thoracic and Cardiovascular Surgery, Heart Centre North Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany
Am J Clin Nutr 95:91-100. 2012Low vitamin D status may increase mortality risk.
- Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South AfricaAdrian R Martineau
Division of Mycobacterial Research, National Institute of Medical Research, Mill Hill NW7 1AA, United Kingdom
Proc Natl Acad Sci U S A 108:19013-7. 2011b>Vitamin D deficiency is associated with susceptibility to tuberculosis (TB) in HIV-uninfected people in Europe, but it is not known whether such an association exists among HIV-infected people in subtropical Africa...
- Vitamin D controls T cell antigen receptor signaling and activation of human T cellsMarina Rode von Essen
Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Nat Immunol 11:344-9. 2010..Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR)...
- High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trialAn Lehouck
University Hospitals Leuven, Belgium
Ann Intern Med 156:105-14. 2012..Because many patients with chronic obstructive pulmonary disease (COPD) have vitamin D deficiency, effects of vitamin D supplementation may extend beyond preventing osteoporosis.
- Activated injectable vitamin D and hemodialysis survival: a historical cohort studyMing Teng
Fresenius Medical Care North America, Lexington, Massachusetts, USA
J Am Soc Nephrol 16:1115-25. 2005..ESRD commonly experience secondary hyperparathyroidism, a condition primarily managed with activated injectable vitamin D. The biologic effects of vitamin D, however, are widespread, and it is possible that activated injectable ..
- Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of ageCarlos A Camargo
Center for D receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Clin Nutr 85:788-95. 2007b>Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown.
- Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practiceJean Claude Souberbielle
Laboratoire de Physiologie, CHU Necker, Paris, France
Autoimmun Rev 9:709-15. 2010There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases...
- Vitamin D and cardiovascular outcomes: a systematic review and meta-analysisMohamed B Elamin
Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 96:1931-42. 2011Several studies found association between vitamin D levels and hypertension, coronary artery calcification, and heart disease.
- Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markersArmin Zittermann
Klinik für Thorax und Kardiovaskularchirurgie and Institut für Laboratoriums und Transfusionsmedizin, Herzzentrum NRW, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
Am J Clin Nutr 89:1321-7. 2009High blood concentrations of parathyroid hormone and low concentrations of the vitamin D metabolites 25-hydroxyvitamin D [25(OH)D] and calcitriol are considered new cardiovascular disease risk markers...
- Vitamin D status: measurement, interpretation, and clinical applicationMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
Ann Epidemiol 19:73-8. 2009b>Vitamin D, the sunshine vitamin, is now recognized not only for its importance in promoting bone health in children and adults but also for other health benefits, including reducing the risk of chronic diseases such as autoimmune ..
- Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention studyRolf Jorde
Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
Am J Epidemiol 171:903-8. 2010..and 2008 Tromsø surveys and 2) every third month for 1 year in 94 subjects randomly assigned to placebo in a vitamin D intervention study...
- Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trialsH A Bischoff-Ferrari
Centre on Aging and Mobility, University of Zurich, Switzerland
BMJ 339:b3692. 2009To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals.
- Vitamin effects on the immune system: vitamins A and D take centre stageJ Rodrigo Mora
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Nat Rev Immunol 8:685-98. 2008..Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity...
- Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004Juhi Kumar
Children s Hospital at Montefiore, Bronx, New York, USA
Pediatrics 124:e362-70. 2009..To determine the prevalence of 25-hydroxyvitamin D (25[OH]D) deficiency and associations between 25(OH)D deficiency and cardiovascular risk factors in children and adolescents...
- Vitamin D: a pleiotropic hormoneAnnemieke Verstuyf
Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
Kidney Int 78:140-5. 2010The secosteroid hormone 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is the natural ligand for the vitamin D receptor, a member of the nuclear receptor superfamily...
- Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthmaCarlos A Camargo
Center for D receptor Activation Research, Massachusetts General Hospital, 326 Cambridge St, Suite 410, Boston, MA 02114, USA
Pediatrics 127:e180-7. 2011Higher maternal intake of vitamin D during pregnancy is associated with a lower risk of wheezing in offspring. The relationship between cord-blood levels of 25-hydroxyvitamin D (25[OH]D) and childhood wheezing is unknown...
- Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular eventsLu Wang
Brigham and Women s Hospital and Harvard School of Public Health, Boston, Massachusetts 02215, USA
Ann Intern Med 152:315-23. 2010b>Vitamin D and calcium may affect the cardiovascular system independently and interactively.
- Vitamin D: A millenium perspectiveMichael F Holick
Vitamin D Laboratory, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
J Cell Biochem 88:296-307. 2003b>Vitamin D is one of the oldest hormones that have been made in the earliest life forms for over 750 million years. Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D...
- Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studiesLu Wang
Brigham and Women s Hospital, Boston, MA 02215, USA
Circ Cardiovasc Qual Outcomes 5:819-29. 2012b>Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear.
- Vitamin D, cognition, and dementia: a systematic review and meta-analysisCynthia Balion
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
Neurology 79:1397-405. 2012To examine the association between cognitive function and dementia with vitamin D concentration in adults.
- Vitamin D2 is much less effective than vitamin D3 in humansLaura A G Armas
Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
J Clin Endocrinol Metab 89:5387-91. 2004..physicians commonly report equivocal responses to seemingly large doses of the only high-dose calciferol (vitamin D(2)) available in the U.S. market...
- Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trialJoanna Mitri
Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Boston, MA 02111, USA
Am J Clin Nutr 94:486-94. 2011A suboptimal vitamin D and calcium status has been associated with higher risk of type 2 diabetes in observational studies, but evidence from trials is lacking.
- Vitamin D levels, lung function, and steroid response in adult asthmaE Rand Sutherland
Department of Medicine, University of Colorado, Denver, Colorado, USA
Am J Respir Crit Care Med 181:699-704. 2010Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma.
- Oral active vitamin D is associated with improved survival in hemodialysis patientsManuel Naves-Díaz
Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto Reina Sofia de Investigacion, REDinREN del ISCIII, Universidad de Oviedo, Julian Claveria s n, 33006 Oviedo, Spain
Kidney Int 74:1070-8. 2008Injection of active vitamin D is associated with better survival of patients receiving chronic hemodialysis...
- Update in vitamin DJohn S Adams
UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
J Clin Endocrinol Metab 95:471-8. 2010The past decade, particularly the last 18 months, witnessed a vigorous increase in interest in vitamin D from both the lay and biomedical worlds...
- Vitamin D deficiency in children and its management: review of current knowledge and recommendationsMadhusmita Misra
Pediatric Endocrine and Neuroendocrine Units, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Pediatrics 122:398-417. 2008Given the recent spate of reports of vitamin D deficiency, there is a need to reexamine our understanding of natural and other sources of vitamin D, as well as mechanisms whereby vitamin D synthesis and intake can be optimized...
- Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohortsKarani S Vimaleswaran
Centre for Paediatric Epidemiology and Biostatistics and MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom
PLoS Med 10:e1001383. 2013Obesity is associated with vitamin D deficiency, and both are areas of active public health concern...
- 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adultsKristen L Jablonski
Department of Integrative Physiology, University of Colorado, Boulder, Colo 80309, USA
Hypertension 57:63-9. 2011..hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, and that this is linked to inflammation...
- High prevalence of vitamin D deficiency among pregnant women and their newborns in northern IndiaAlok Sachan
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Am J Clin Nutr 81:1060-4. 2005b>Vitamin D deficiency is prevalent in India, a finding that is unexpected in a tropical country with abundant sunshine. Vitamin D deficiency during pregnancy has important implications for the newborn and infant...
- Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictorsElina Hypponen
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
Am J Clin Nutr 85:860-8. 2007Increased awareness of the importance of vitamin D to health has led to concerns about the prevalence of hypovitaminosis D in many parts of the world.
- Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination surveyPeter N Black
Department of Medicine, University of Auckland, Private Bag 92019 Auckland, New Zealand
Chest 128:3792-8. 2005..Low concentrations of vitamin D have been associated with a number of diseases, including osteoporosis, hypertension, and type I diabetes...
- Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysisKelechi E Nnoaham
Department of Public Health, Oxfordshire Primary Care Trust, Richard Building, Old Road Campus, Headington, Oxford OX3 7LG, UK
Int J Epidemiol 37:113-9. 2008To explore the association between low serum vitamin D and risk of active tuberculosis in humans.
- Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiencySigrid Hatse
Laboratory of Experimental Oncology LEO, Department of Oncology, KU Leuven, University Hospitals Leuven, Leuven Cancer Institute, Belgium
Carcinogenesis 33:1319-26. 2012..and clinical disease outcome in breast cancer patients and assessed the impact of genetic determinants of vitamin D insufficiency...
- Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studiesYiqing Song
Department of Medicine, Harvard Medical School, Boston, MA, USA
Diabetes Care 36:1422-8. 2013To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes.
- Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin DHuei Ju Ting
Department of Urology, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 288:1-9. 2013The anti-tumor effect of vitamin D has been well recognized but its translational application is hindered by side effects induced by supra-physiological concentration of vitamin D required for cancer treatment...
- Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidencePawel Pludowski
Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children s Memorial Health Institute, Warsaw, Poland
Autoimmun Rev 12:976-89. 2013Optimal vitamin D intake and its status are important not only for bone and calcium-phosphate metabolism, but also for overall health and well-being...
- Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trialsEvropi Theodoratou
Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK
BMJ 348:g2035. 2014To evaluate the breadth, validity, and presence of biases of the associations of vitamin D with diverse outcomes.
- Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney diseaseMartin H de Borst
Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
J Am Soc Nephrol 22:1603-9. 2011There is increasingly evidence that the interactions between vitamin D, fibroblast growth factor 23 (FGF-23), and klotho form an endocrine axis for calcium and phosphate metabolism, and derangement of this axis contributes to the ..
- Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trialStefanie S Schleithoff
Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany
Am J Clin Nutr 83:754-9. 2006..In vitro studies suggest that vitamin D suppresses proinflammatory cytokines and increases antiinflammatory cytokines.
- The vitamin D status of Canadians relative to the 2011 Dietary Reference Intakes: an examination in children and adults with and without supplement useSusan J Whiting
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
Am J Clin Nutr 94:128-35. 2011The 2011 Dietary Reference Intakes (DRIs) for vitamin D use 25-hydroxyvitamin D [25(OH)D] concentrations to define vitamin D deficiency (<30 nmol/L), the Estimated Average Requirement (40 nmol/L), and the Recommended Dietary Allowance ..
- Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adultsJennifer L Rosenblum
Massachusetts General Hospital Weight Center and Gastrointestinal Unit, Massachusetts General Hospital, Boston, USA
Am J Clin Nutr 95:101-8. 2012Several studies suggest that calcium and vitamin D (CaD) may play a role in the regulation of abdominal fat mass.
- Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetesJason D Cooper
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Diabetes 60:1624-31. 2011b>Vitamin D deficiency (25-hydroxyvitamin D [25(OH)D] <50 nmol/L) is commonly reported in both children and adults worldwide, and growing evidence indicates that vitamin D deficiency is associated with many extraskeletal chronic ..
- Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women's Health Initiative (WHI) limited-access data setMark J Bolland
Department of Medicine, University of Auckland, Auckland, New Zealand
Am J Clin Nutr 94:1144-9. 2011Frequent use of personal, nonprotocol calcium supplements obscured an adverse effect of coadministered calcium and vitamin D (CaD) on cardiovascular risk in the Women's Health Initiative (WHI).
- Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysisAnn Burgaz
Institute of Environmental Medicine, Karolinska Institiute, Stockholm, Sweden
J Hypertens 29:636-45. 2011Increasing evidence indicates that vitamin D may influence the risk of hypertension, which is a major risk factor for cardiovascular disease...
- Calcium/vitamin D supplementation and cardiovascular eventsJudith Hsia
Department of Medicine, George Washington University, Washington, DC, USA
Circulation 115:846-54. 2007..We evaluated the risk of coronary and cerebrovascular events in the Women's Health Initiative randomized trial of calcium plus vitamin D supplementation.
- Low vitamin D status despite abundant sun exposureN Binkley
University of Wisconsin Osteoporosis Research Program, Madison, WI 53705, USA
J Clin Endocrinol Metab 92:2130-5. 2007Lack of sun exposure is widely accepted as the primary cause of epidemic low vitamin D status worldwide...
- Global vitamin D status and determinants of hypovitaminosis DA Mithal
Indraprastha Apollo Hospitals, Sarita Vihar, Delhi Mathura Road, 110044 New Delhi, India
Osteoporos Int 20:1807-20. 2009This review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of ..
- Nonclassic actions of vitamin DDaniel Bikle
Veterans Affairs Medical Center 111N, 4150 Clement Street, San Francisco, California 94121, USA
J Clin Endocrinol Metab 94:26-34. 2009b>Vitamin D receptors are found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney...
- Prevalence and correlates of vitamin D deficiency in US adultsKimberly Y Z Forrest
Department of Public Health and Social Work, Slippery Rock University of Pennsylvania, Slippery Rock, PA 16057, USA
Nutr Res 31:48-54. 2011Mounting evidence suggests that vitamin D deficiency could be linked to several chronic diseases, including cardiovascular disease and cancer...
- Vitamin D signalling pathways in cancer: potential for anticancer therapeuticsKristin K Deeb
Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA
Nat Rev Cancer 7:684-700. 2007Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers...
- Genome-wide association study of circulating vitamin D levelsJiyoung Ahn
Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
Hum Mol Genet 19:2739-45. 2010The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer...
- FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasisTakashi Shimada
Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, Takasaki, Gumma, Japan
J Bone Miner Res 19:429-35. 2004..FGF-23 caused a reduction in serum 1,25-dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D metabolism followed by hypophosphatemia...
- Vitamin D and human health: lessons from vitamin D receptor null miceRoger Bouillon
Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Herestraat 49, O and N 1 bus 902, 3000 Leuven, Belgium
Endocr Rev 29:726-76. 2008The vitamin D endocrine system is essential for calcium and bone homeostasis...
- Pilot and definitive studies to evaluate Insertional MutagenesisLU TAYLOR; Fiscal Year: 2012..osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D metabolites) and other toxicological effects in Sprague-Dawley rats...
- Studies to Evaluate the Toxicological Potential of Test ArticlesLU TAYLOR; Fiscal Year: 2010..osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D metabolites) and other toxicological effects in Sprague-Dawley rats...
- Comprehensive biomarker study to capitalize on existing GWAS in 10K South AsiansDanish Saleheen; Fiscal Year: 2010..leptin, resistin, liver function enzymes);(3) renal function (creatinine, cystatin C, ADMA, uric acid, 25(OH)vitamin D, parathyroid hormone);and (4) inflammation and hemostasis (hsCRP, MCP-1, IL-6, sTNFRII, sVCAM-1, sICAM-1, serum ..
- Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate CancerBandana Chatterjee; Fiscal Year: 2013..b>Vitamin D deficiency is a common problem among the elderly...
- Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C FamilyJohn S Adams; Fiscal Year: 2013..and that of an adolescent human female with a similar phenotype led us to the discovery of a novel means for vitamin D and estrogen resistance in primates, including man...
- Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular FunctionANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010DESCRIPTION (provided by applicant): Vitamin D deficiency is much more common in African Americans than whites...
- Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T cInsoo Kang; Fiscal Year: 2010..FOXP3 and IL-17 gene regulation through identifying and characterizing the binding site(s) of the vitamin D receptor in the human FOXP3 and IL-17 genes...
- Bioassay for Breast Cancer PreventionJoEllen Welsh; Fiscal Year: 2010..These studies will provide proof of principle of this concept and establish the bioassay through study of vitamin D and genomic stability...
- Microsomal Cytochromes P450 and their Interactions with their Redox PartnersLucy A Waskell; Fiscal Year: 2013..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids. Cyts P450 exists in virtually every organ and tissue of humans...
- Lung VITamin D and OmegA-3 TriaL (Lung VITAL)Diane R Gold; Fiscal Year: 2013..The current modalities for treatment of COPD are limited, and prevalence of vitamin D deficiency is high...
- Effects of Gastric Bypass Surgery on Calcium Metabolism and the SkeletonANNE LOUISE SCHAFER; Fiscal Year: 2013..This is of critical concern given the tremendous impact of osteoporosis and fracture in both men and women. Vitamin D deficiency due to obesity and post-surgical malabsorption may partially explain the decline in bone mass ..
- Role of beta-endorphin in cancer therapy induced fatigueDavid E Fisher; Fiscal Year: 2013..linkage may relate to evolutionary advantages of sun-seeking behaviors to maintain UV derived cutaneous vitamin D synthesis...
- PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMENWalter C Willett; Fiscal Year: 2010..Cross-cutting themes are the investigation of vitamin D, inflammatory, and energy balance pathways as they relate to cancer incidence...
- MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALINGMoosa Mohammadi; Fiscal Year: 2013..major metabolic processes including glucose, lipid, cholesterol, and bile acid metabolism, and phosphate/vitamin D homeostasis...
- New drug VS-110 for treating inflammatory bowel diseasesJinshyun Ruth Wu-Wong; Fiscal Year: 2013..New agents are needed to treat UC and CD and prevent relapse. Vitamin D receptor (VDR), once activated by its endogenous hormone calcitriol (1,25(OH) 2D3), modulates signaling pathways ..
- Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal AxisGenevieve S Neal-Perry; Fiscal Year: 2012..enzyme converting 25-hydroxyvitamin D3 to the most active form of vitamin D3, 1,25-dihydroxyvitamin D3) and the vitamin D receptor (VDR), a nuclear hormone receptor super-family member, are distributed throughout many organ systems ..
- New drug Vida-5 for treating chronic kidney disease progressionJinshyun Ruth Wu-Wong; Fiscal Year: 2011..b>Vitamin D receptor modulators (VDRMs) have been shown to reduce proteinuria/albuminuria in CKD patients and also provide ..
- Novel drug VS-105 for treatment of diabetic nephropathyJinshyun Ruth Wu-Wong; Fiscal Year: 2012..b>Vitamin D receptor modulators (VDRMs) have been shown to reduce proteinuria/albuminuria in diabetic nephropathy patients ..
- Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint PainKaren H Costenbader; Fiscal Year: 2013..to leverage a newly NIH-funded large, randomized, double-blind, placebo-controlled, 2x2 factorial trial of vitamin D (in the form of vitamin D3 [cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + ..
- Dietary Risk for Colon Cancer in the MouseLeonard H Augenlicht; Fiscal Year: 2013..and our data that this cytokine is elevated by the NWD1, but that this is prevented by elevating calcium and vitamin D in NWD2, we will use a novel neutralizing monoclonal Ab to IL12 to determine whether this eliminates or ..
- Genetic Epidemiology of Life-Threatening Influenza Infection in ChildrenAdrienne Randolph; Fiscal Year: 2009..protein (RIG-I), the collectins surfactant proteins A and D (SP-A, SP-D) and mannose binding lectin (MBL), Vitamin D related genes (VDR), and genes influencing down-stream cytokines such as interferon-alpha (IFN-[unreadable]), ..
- Assessment of Bone Composition Through a Novel Liquid/Solid State MRI MethodAra Nazarian; Fiscal Year: 2013..of postmenopausal women who fracture their hip and have no other cause for low bone mass, are deficient in vitamin D. Vitamin D deficiency can result in osteomalacia, where the mineral composition and bone tissue volume are both ..
- Assessment of Bone Composition Through a Novel Liquid/Solid State MRI MethodAra Nazarian; Fiscal Year: 2011..of postmenopausal women who fracture their hip and have no other cause for low bone mass, are deficient in vitamin D. Vitamin D deficiency can result in osteomalacia, where the mineral composition and bone tissue volume are both ..
- EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSISDevendra K Agrawal; Fiscal Year: 2013..We hypothesize that obesity-induced inflammatory phenotype of epicardial fat is exacerbated by vitamin D deficiency leading to endothelial dysfunction and enhanced intimal hyperplasia following coronary intervention...
- VITamin D and OmegA-3 TriaL: Effects on Bone Structure and ArchitectureMERYL SUSAN LEBOFF; Fiscal Year: 2013DESCRIPTION (provided by applicant): There is a high prevalence of inadequate vitamin D levels in the United States...
- Maternal-fetal vitamin D status and child adiposity, insulin resistance and BPSusanna Y Huh; Fiscal Year: 2010..Deficiency of Vitamin D, a fat-soluble hormone, may be a novel modifiable risk factor in the development of obesity and related sequelae...
- Vitamin D and Arterial Function in Patients with Chronic Kidney DiseaseJessica B Kendrick; Fiscal Year: 2013..fellow at the University of Colorado at Denver Health Sciences Center whose main area of interest is in vitamin D dysregulation and its relationship with all-cause mortality and cardiovascular disease (CVD) in patients with ..
- Vitamin D Effect on Body Composition During Behavioral Weight Loss in WomenANNE M MCTIERNAN; Fiscal Year: 2013..A growing body of evidence suggests that vitamin D has anti-carcinogenic effects by modulating cellular growth and apoptosis, and by reducing angiogenesis...
- Classical and non-classical responses to vitamin D in children: the role of DBP gThomas O Carpenter; Fiscal Year: 2010..80% minorities) with either low or normal circulating 25-hydroxyvitamin D (25-OHD) levels, and have found that vitamin D deficiency (circulating 25-OHD <20 ng/ml) occurs in 13% of over 750 6 mo...
- Lifestyle and Molecular Factors of Bone Health in Breast Cancer SurvivorsSong Yao; Fiscal Year: 2013..secondary outcome) in association with 1) modifiable lifestyle factors such as physical activity, diet, vitamin D and calcium supplement use, smoking, and alcohol consumption;2) germline genetic variations in estrogen and bone ..
- Vitamin D and Vascular Function in Obese ChildrenKumaravel Rajakumar; Fiscal Year: 2013DESCRIPTION (provided by applicant): Vitamin D deficiency is emerging as an independent risk factor for subclinical vascular dysfunction, metabolic syndrome, and later cardiovascular disease (CVD) in children...
- Molecular &Cellular Effects of Human Mutations in Cytochrome P450 ReductaseSatya Prakash Panda; Fiscal Year: 2013..laboratory) bone-specific knockout mouse model using micro CT, differential staining and determination of vitamin D, retinoic acid, cholesterol, steroid, and lipid serum levels in these mice...
- VITAMIN D DEFICIENCY, INSULIN RESISTANCE AND CARDIOVASCULAR DISEASECarlos Bernal-Mizrachi; Fiscal Year: 2013..Our preliminary data indicates that vitamin D receptor signaling modulates adhesion, migration, and foam cell formation in macrophages and appears to decrease ..
- Establishing the Precursors of Osteoporosis in ChildrenXiping Xu; Fiscal Year: 2010..OC), tartrate-resistant acid phosphatase 5b (TRAP-5b);nutritional markers: magnesium, vitamin K1, and 25(OH) vitamin D;and also examine other relevant biomarkers covered by the funded MS study, including steroid hormones: androgen, ..
- Vitamin D and fibroblast growth factor 23 physiology in adolescent girlsDEBORAH MICHELLE MITCHELL; Fiscal Year: 2012..growth factor 23 (FGF23) is a hormone with a central role in regulating circulating phosphate (Pi) levels and vitamin D metabolism...
- Dynamic Mechanisms of Vitamin D-Induced Gene ExpressionJ Wesley Pike; Fiscal Year: 2012..Despite a general description of vitamin D action on bone, the mechanisms that permit orchestration of these activities by 1,25(OH)2D3 at the genome-wide ..
- Diet, Biomarkers and Lung FunctionRui Jiang; Fiscal Year: 2010..lung function, lower lung density, and greater longitudinal decline in lung density in MESA;C) high intake of vitamin D and dairy products and elevated levels of 25(OH) vitamin D are associated with higher lung function, higher lung ..
- (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon CancerYan Chun Li; Fiscal Year: 2013..by which a drug that is chronically used for other indications protects against cancer incidence and mortality? Vitamin D (VD) is a widely and chronically used supplement for maintenance of bone health and for treatment of ..
- Vitamin D Deficiency in Glomerular DiseaseMichelle Denburg; Fiscal Year: 2013..Her research is focused on the extra-skeletal actions of vitamin D and the unique challenges of managing vitamin D deficiency in patients with glomerular diseases complicated by ..
- Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the ElderlyNancy Berliner; Fiscal Year: 2013..erythropoietic cell signaling and the development of anemia in the elderly in the setting of the newly launched VITamin D and OmegA-3 TriaL (VITAL)...
- Biological &Environmental Mediators of Vitamin D and Aggressive Prostate CancerADAM BRYANT MURPHY; Fiscal Year: 2013DESCRIPTION (provided by applicant): Murphy, Adam B. Biological and Environmental Mediators of Vitamin D and Aggressive Prostate Cancer! Candidate: Dr. Adam Murphy is an academic urologist who completed residency two years ago...
- Toll-like Receptor 2, Vitamin D, and Extrapulmonary TuberculosisCHRISTINA A FISKE; Fiscal Year: 2013..evidence suggests that pathogen recognition receptors called Toll-like receptors (TLRs), specifically TLR2, and vitamin D play a major role in the immune response to M. tuberculosis...
- Vitamin D in Prostate Cancer: Tumor Vasculature EffectsCandace S Johnson; Fiscal Year: 2012DESCRIPTION (provided by applicant): Calcitriol (vitamin D or 1,25 dihydroxycholecalciferol), a central factor in bone and mineral metabolism, has significant antitumor activity in vitro and in vivo...
- Pilot Study of Arsenic, UV and Melanoma in a Non-Hispanic White PopulationJanice W Yager; Fiscal Year: 2011..repair capacity in melanoma and non-melanoma patients will be evaluated controlling for UV exposure and serum vitamin D levels...
- Participation in Cytochrome b5 in Anesthetic MetabolismLucy A Waskell; Fiscal Year: 2010..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids. Cyts P450 exist in virtually every organ and tissue of humans...
- Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal WomenJoan Lappe; Fiscal Year: 2013..inverse correlation between cancer mortality rates and regional solar UV-B radiation exposure, a major source of vitamin D (vit D), has been found for cancers of the breast, colon, rectum, ovary, prostate, stomach, and numerous other ..
- Safe and Effective Vitamin D Supplementation in HIVVirginia A Stallings; Fiscal Year: 2012The key role of vitamin D (vit D) in maintaining optimal bone health has long been recognized, but its role in modulating the innate immune response and inflammatory reaction has only recently come under active investigation...
- Randomized trial of active vitamin D, cholecalciferol and placebo for CKD-MBDSharon M Moe; Fiscal Year: 2011..parathyroid hormone for the treatment of CKD-MBD is pharmacologic preparations of the kidney activated form of vitamin D- calcitriol and analogs such as doxercalciferol...
- Vitamin D deficiency and treatment in male veterans at risk for diabetesElena Barengolts; Fiscal Year: 2013DESCRIPTION (provided by applicant): Emerging evidence suggests that higher vitamin D blood levels are associated with better health outcomes including type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) but it remains ..
- Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on FracturesMERYL SUSAN LEBOFF; Fiscal Year: 2013..by applicant): Osteoporotic fractures are major public health problems that have been associated with low vitamin D levels. Previous data strongly suggest that doses of vitamin D = 700 IU/day reduce fractures and possibly falls...
- Non-Classical Manifestations of Primary HyperparathyroidismShonni J Silverberg; Fiscal Year: 2013..The themes and Specific Aims (SA's) of this research are: Theme 1. Vitamin D deficiency in PHPT: SA1a...
- Integrated Cardio-Renal Risk Prediction Models in Type 1 DiabetesMarian J Rewers; Fiscal Year: 2010..Increased systemic inflammation is present in type 1 diabetes and inflammatory mediators such as uric acid, vitamin D and bone metabolism markers have been suggested to play a role in both renal and cardiovascular diseases...
- A Prospective Study of Diet and Prostate CancerEdward Giovannucci; Fiscal Year: 2011We propose to examine four inter-related pathogenic pathways for prostate carcinogenesis: the vitamin D axis, inflammation, sex steroids, and insulin/insulin-like growth factor signaling...
- Regulation of Bone Mineralization in Renal OsteodystrophyISIDRO BENJAMIN SALUSKY; Fiscal Year: 2012..hand, fibroblast growth factor 23 (FGF-23) has an important biological role in the control of phosphate and vitamin D metabolism in individuals with normal renal function...
- Role of vitamin D receptor in DNA repairDennis H Oh; Fiscal Year: 2013DESCRIPTION (provided by applicant): The role of vitamin D in ameliorating various health outcomes other than bone-related metabolism is controversial...
- Milk osteopontin, a nutritional therapeutic intervention for alcoholic hepatitisNatalia Nieto; Fiscal Year: 2013..Key events for the onset and progression of alcoholic hepatitis result from the gut-to-liver interaction. Vitamin D deficiency is highly prevalent in patients with alcoholic hepatitis...
- Vitamin D and the Immune SystemLawrence Steinman; Fiscal Year: 2012..the mechanisms involved will result in new concepts in our understanding of the interaction between the vitamin D endocrine system and the immune system that may suggest therapeutic targets for the control of MS and other TH17 ..
- Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapyYu Zhang; Fiscal Year: 2012..b) restoration or reversal of bone loss induced by ovariectomy or mineral deficiency, compared with calcium + vitamin D supplement;(3) evaluate the effect of MZF-CaP and MZ-CaP/FF on prevention of bone loss in a larger animal model (..
- Orthopaedic Wear Debris, Vitamin D, and Innate ImmunityJohn S Adams; Fiscal Year: 2010..and 2] innate immune signaling in primary isolates of human macrophages is mediated by TLRs and impaired by a vitamin D-insufficient status in the host. Two aims are proposed to test the above-stated hypothesis...
- Vitamin D, Epstein-Barr virus infection, and cigarette smoking and risk of multipAlberto Ascherio; Fiscal Year: 2013..Converging evidence from multiple studies suggests that inadequate vitamin D nutrition, infection with the Epstein-Barr virus (EBV), and cigarette smoking are important risk factors for MS...
- Southern Community Cohort StudyWei Zheng; Fiscal Year: 2013..well positioned to address, many for the first time among African Americans, including the roles of obesity, vitamin D, specific infections (Chlamydia pneumoniae, Trichomonas vaginalis, Helicobacter pylori, and xenotropic murine ..
- Melanoma Prevention: Using the SunMarianne Berwick; Fiscal Year: 2013..Examples of novel initiatives include exploration of interaction effects of sunlight and Vitamin D with the vitamin D receptor and its pathway, immunological factors and hormonal influences on both etiology and ..
- VITAMIN D HORMONE MECHANISM OF ACTION IN CULTURED CELLSMARK HAUSSLER; Fiscal Year: 1999This application proposes the continuation of our investigation of the molecular and biological functions of the vitamin D hormone (1,25(OH)2D3) in cultured cell systems...
- Supplemental Vitamin D and Functional Outcomes in Early AdolescenceRichard D Lewis; Fiscal Year: 2010b>Vitamin D intakes'in children do not meet current US Dietary Reference Intake (DRI) recommendations and emerging evidence suggests that a significant number of children, particularly those with darker skin pigmentation, have ..
- Prevention of Vitamin D Deficiency in Breastfed InfantsEkhard Ziegler; Fiscal Year: 2009b>Vitamin D deficiency occurs among breastfed infants in all parts of the U.S. but is particularly common among infants with dark skin pigmentation and infants living in the northern parts of the U.S...
- OSTEOPOROSIS/DIHYDROXYVITAMIN REGULATED GENE EXPRESSIONSylvia Christakos; Fiscal Year: 1993..in both male and female rats in the expression of two genes involved in intestinal calcium absorption and in vitamin D regulated renal handling of calcium; calbindin (the vitamin D- dependent calcium binding protein) and the ..
- Dose-dependent anti-inflammatory effects of vitamin D in a human gingivitis modelRaul Garcia; Fiscal Year: 2009..Data from in-vitro and animal studies suggest anti-inflammatory effects of vitamin D;however, if and over what dose-range vitamin D may have anti- inflammatory effects in humans is uncertain...
- VITAMIN D BINDING PROTEINNancy Cooke; Fiscal Year: 2003b>Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
- Claudin-2, Claudin-12 and Cadherin-17: Novel Targets of Vitamin D ActionANGELA R PORTA; Fiscal Year: 2011DESCRIPTION (provided by applicant): The object of this proposal is to obtain a better understanding of vitamin D action on intestinal calcium transport...
- Nutritional Intervention for Age-Related Muscular Function and Strength LossesJohn A Rathmacher; Fiscal Year: 2010..These data form the basis of our current hypothesis that the combination of HMB and Vitamin D supplementation will be synergistic and will result in significant enhancements in overall muscle strength, ..
- Vitamin D status in pregnant womenTheresa Scholl; Fiscal Year: 2009DESCRIPTION (provided by investigator): Vitamin D is present in food either naturally or by fortification and included in nutritional supplements. It is also synthesized photochemically by the skin from ultraviolet B radiation...
- Vitamin D: A Negative Regulator of Renin ExpressionYan Chun Li; Fiscal Year: 2003The main goal of this application is to define the role of vitamin D and parathyroid hormone (PTH) in the regulation of the renin-angiotensin system in vivo, which plays a crucial role in the regulation of blood pressure, electrolyte ..
- Relationships between Skin Pigmentation, Vitamin D and Blood PressureFLOJAUNE GRIFFIN; Fiscal Year: 2009..The goal of this study is to characterize the effect of skin pigmentation on serum 25- hydroxycholecalciferol (vitamin D) levels, and, in turn, ascertain their association with blood pressure among women as they age...
- Calcium/Vitamin D, Biomarkers & Colon Polyp PreventionRoberd Bostick; Fiscal Year: 2009..biological plausibility and animal experimental evidence for protection against colorectal cancer by calcium and vitamin D, calcium significantly reduced adenoma recurrence in a large clinical trial, and the observational literature ..
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra G Mehta; Fiscal Year: 2010DESCRIPTION (provided by applicant): The role of vitamin D in colorectal cancer (CRC) prevention is well recognized...
- Calcium, Vitamin D, and Markers of Adenomatous PolypsRoberd Bostick; Fiscal Year: 2006..biological plausibility and animal experimental evidence for protection against colorectal cancer by calcium and vitamin D, calcium significantly reduced adenoma recurrence in a large clinical trial in humans (yet the previously ..
- Vitamin D Deficiency Augments Renin-Angiotensin System Activity in ObesityAnand Vaidya; Fiscal Year: 2011DESCRIPTION (provided by applicant): The overall aim of this study is to examine whether Vitamin D supplementation reduces endogenous renin-angiotensin system activity (RAS) in obesity...
- Genetic Variation in Vitamin D Metabolism and BMT OutcomesKIMBERLY ROBIEN; Fiscal Year: 2009..Because of its immunomodulatory and cell cycle regulatory activities, maintaining adequate vitamin D status throughout the treatment course may decrease risk of GVHD and disease relapse, which in turn, could ..
- Vitamin D Control of TGFa/EFG Receptor Growth SignalingAdriana Dusso; Fiscal Year: 2006..While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the underlying mechanisms are poorly ..
- VITAMIN D MEDIATED GENE REGULATION IN B LYMPHOCYTESJohn Morgan; Fiscal Year: 2000..the Applicant's Abstract): The biological effects of 1,25-dihydroxyvitamin D (1,25D), the active metabolite of vitamin D, are assumed to be effected by interaction of the hormone with specific intracellular receptors and their ..
- Vitamin D induction of antibacterial activity in gingival cellsGill Diamond; Fiscal Year: 2009..LL-37 were induced in myeloid cells and several cell lines by a less toxic agent, the hormonally active form of vitamin D, 1,25(OH)2-vitamin D3...
- EFFECTS OF VITAMIN D DEFICIENCY ON MALE REPRODUCTIONGARY KWIECINSKI; Fiscal Year: 1992The long-term objectives of this application are to identify sites and mechanisms of action of vitamin D that are responsible for the reduced fertility observed in vitamin D deficiency...
- Vitamin D Receptor-Cofactor Interactions as Targets for Novel Drug DiscoveryJohn Norris; Fiscal Year: 2009The secosteroid vitamin D plays a critical role in cell differentiation, proliferation and mineral homeostasis. As such, this hormone is essential for the development and maintenance of healthy bone...