pancreatic function tests

Summary

Summary: Tests based on the biochemistry and physiology of the exocrine pancreas and involving analysis of blood, duodenal contents, feces, or urine for products of pancreatic secretion.

Top Publications

  1. ncbi [Clinical symptoms and diagnostic standards in chronic pancreatitis]
    Keisho Kataoka
    Nihon Naika Gakkai Zasshi 93:29-37. 2004
  2. ncbi Chronic pancreatitis. The problems of diagnostic criteria
    Makoto Otsuki
    Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Pancreatology 4:28-41. 2004
  3. ncbi Pancreas divisum, an evidence-based review: part I, pathophysiology
    Steven D Klein
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Gastrointest Endosc 60:419-25. 2004
  4. ncbi Fecal elastase-1 determination: 'gold standard' of indirect pancreatic function tests?
    S Luth
    Dept of Medicine II Gastroenterology Hepatology, University Hospital of Heidelberg at Mannheim, Germany
    Scand J Gastroenterol 36:1092-9. 2001
  5. ncbi Comparing the urinary pancreolauryl ratio and faecal elastase-1 as indicators of pancreatic insufficiency in clinical practice
    D A Elphick
    Department of Gastroenterology, Barnsley District General Hospital, Barnsley, UK
    Pancreatology 5:196-200. 2005
  6. ncbi Low fecal elastase-1 in type I diabetes mellitus
    A Icks
    Department of Biometrics and Epidemiology, German Diabetes Research Institute at Heinrich Heine University, Dusseldorf, Germany
    Z Gastroenterol 39:823-30. 2001
  7. ncbi High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients
    Philip D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Pancreatology 3:395-402. 2003
  8. ncbi [The diagnostic validity of non-invasive pancreatic function tests--a meta-analysis]
    E Siegmund
    Institut fur Klinische Chemie und Pathobiochemie, Medizinische Fakultät der Universität Rostock
    Z Gastroenterol 42:1117-28. 2004
  9. ncbi Now that fecal elastase is available in the United States, should clinicians start using it?
    Paul G Lankisch
    Clinic of Internal Medicine, Municipal Clinic of Lueneburg, Boegelstrasse 1, D 21339 Lueneburg, Germany
    Curr Gastroenterol Rep 6:126-31. 2004
  10. ncbi Pancreatic enzyme therapy and clinical outcomes in patients with cystic fibrosis
    Susan S Baker
    Department of Pediatrics, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, USA
    J Pediatr 146:189-93. 2005

Detail Information

Publications170 found, 100 shown here

  1. ncbi [Clinical symptoms and diagnostic standards in chronic pancreatitis]
    Keisho Kataoka
    Nihon Naika Gakkai Zasshi 93:29-37. 2004
  2. ncbi Chronic pancreatitis. The problems of diagnostic criteria
    Makoto Otsuki
    Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Pancreatology 4:28-41. 2004
    ..In the JPS Criteria, imaging studies, pancreatic function tests, and histological findings are independent of each other, and thus the diagnosis of chronic pancreatitis ..
  3. ncbi Pancreas divisum, an evidence-based review: part I, pathophysiology
    Steven D Klein
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Gastrointest Endosc 60:419-25. 2004
  4. ncbi Fecal elastase-1 determination: 'gold standard' of indirect pancreatic function tests?
    S Luth
    Dept of Medicine II Gastroenterology Hepatology, University Hospital of Heidelberg at Mannheim, Germany
    Scand J Gastroenterol 36:1092-9. 2001
    Tubeless pancreatic function tests measuring the content of elastase-1 and the activity of chymotrypsin in stool are used with different cut-off levels and with varying success in diagnosing functional impairment of the pancreas...
  5. ncbi Comparing the urinary pancreolauryl ratio and faecal elastase-1 as indicators of pancreatic insufficiency in clinical practice
    D A Elphick
    Department of Gastroenterology, Barnsley District General Hospital, Barnsley, UK
    Pancreatology 5:196-200. 2005
    ..Both tests have previously been validated against 'gold standard' tests of pancreatic function, but their use in a clinical setting has never been directly compared...
  6. ncbi Low fecal elastase-1 in type I diabetes mellitus
    A Icks
    Department of Biometrics and Epidemiology, German Diabetes Research Institute at Heinrich Heine University, Dusseldorf, Germany
    Z Gastroenterol 39:823-30. 2001
    ..Fecal elastase-1 has facilitated evaluation of pancreatic dysfunction in population-based studies...
  7. ncbi High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients
    Philip D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Pancreatology 3:395-402. 2003
    ..In this study we had the opportunity to study more than 1,000 diabetic patients to confirm recent observations in smaller populations...
  8. ncbi [The diagnostic validity of non-invasive pancreatic function tests--a meta-analysis]
    E Siegmund
    Institut fur Klinische Chemie und Pathobiochemie, Medizinische Fakultät der Universität Rostock
    Z Gastroenterol 42:1117-28. 2004
    The paper discusses the non-invasive (tubeless) pancreatic function tests used to diagnose exocrine pancreatic insufficiency (EI)...
  9. ncbi Now that fecal elastase is available in the United States, should clinicians start using it?
    Paul G Lankisch
    Clinic of Internal Medicine, Municipal Clinic of Lueneburg, Boegelstrasse 1, D 21339 Lueneburg, Germany
    Curr Gastroenterol Rep 6:126-31. 2004
    ..Similar to other indirect pancreatic function tests, it has a high sensitivity rate for detecting severe functional impairment of the gland...
  10. ncbi Pancreatic enzyme therapy and clinical outcomes in patients with cystic fibrosis
    Susan S Baker
    Department of Pediatrics, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, USA
    J Pediatr 146:189-93. 2005
    ..To assess the relationship between pancreatic enzyme therapy (PET) and the clinical outcomes of growth, abdominal pain, constipation, gassiness, and number of stools in cystic fibrosis (CF)...
  11. ncbi Pancreatitis and E. coli O157:H7 colitis without hemolytic uremic syndrome
    David A Sass
    Dig Dis Sci 48:415-6. 2003
  12. ncbi Review article: Pancreatic function testing
    R S Chowdhury
    Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610 0214, USA
    Aliment Pharmacol Ther 17:733-50. 2003
    b>Pancreatic function tests are most commonly used to diagnose chronic pancreatitis...
  13. ncbi Early decline of pancreatic function in cystic fibrosis patients with class 1 or 2 CFTR mutations
    Jaroslaw Walkowiak
    Institute of Pediatrics, Department of Gastroenterology and Metabolism, Karol Marcinkowski University of Medical Sciences, 60 572 Poznan, Poland
    J Pediatr Gastroenterol Nutr 40:199-201. 2005
    ..We assessed the decline of pancreatic function in CF infants carrying class 1 or 2 CFTR mutations who were diagnosed in a neonatal screening program...
  14. ncbi Fecal elastase-1 concentration: an indirect test of exocrine pancreatic function and a marker of an enteropathy regardless of cause
    Sanda Nousia-Arvanitakis
    J Pediatr Gastroenterol Nutr 36:314-5. 2003
  15. ncbi Non-invasive quantification of pancreatic exocrine function using secretin-stimulated MRCP
    S Punwani
    Medical Imaging, Middlesex Hospital and Royal Free and University College London Medical School, Mortimer Street, London W1T 3AA, UK
    Eur Radiol 13:273-6. 2003
    ..The MRCP sequence can be used to measure water volume. Sequential MRCP measurements following secretin permitted calculation of volume change and flow rate. This should prove useful as an indicator of pancreatic exocrine function...
  16. pmc Long-term follow-up of a randomized trial comparing the beger and frey procedures for patients suffering from chronic pancreatitis
    Tim Strate
    Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Ann Surg 241:591-8. 2005
    ....
  17. ncbi Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 40:697-704. 2005
    ..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool...
  18. ncbi [Fecal elastase-1: a useful test in pediatric practice]
    L David-Henriau
    Unité de Gastroentérologie Pédiatrique, Departement de Pediatrie, Centre Hospitalier Pellegrin, CHU de Bordeaux, Place Amelie Raba Leon, 33076, Bordeaux Cedex, France
    Arch Pediatr 12:1221-5. 2005
    ..To study fecal elastase-1 (E1F) and chymotrypsin (ChT) in stools for the diagnosis of pancreatic insufficiency in pediatric practice...
  19. ncbi [Comparison of faecal lipase test and faecal elastase-1 test in the assessment of exocrine pancreatic function in cystic fibrosis]
    Jaroslaw Walkowiak
    Klinika Gastroenterologii Dzieciecej i Chorób Metabolicznych, Instytut Pediatrii, Akademia Medyczna, ul Szpitalna 27 33, 60 572 Poznań, Poland
    Med Wieku Rozwoj 7:149-55. 2003
    ..Therefore, the aim of the present study was to compare the sensitivity and the specificity of faecal lipase test to the faecal elastase-1 test in the assessment of exocrine pancreatic function...
  20. ncbi The commercially available ELISA for pancreatic elastase 1 based on polyclonal antibodies does measure an as yet unknown antigen different from purified elastase 1. Binding studies and clinical use in patients with exocrine pancreatic insufficiency
    P D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Z Gastroenterol 41:903-6. 2003
    ..ELISA 2 should be renamed, since obviously it does react with an antigen (antigens) different from elastase 1...
  21. ncbi Quantification of pancreatic zinc output as pancreatic function test: making the secretin-caerulein test applicable to clinical practice
    J Enrique Domínguez-Muñoz
    Department of Gastroenterology, University Hospital, Santiago de Compostela, Spain
    Pancreatology 4:57-62. 2004
    ..The aim of this study was to analyze the accuracy of the secretin-caerulein-stimulated pancreatic zinc output as pancreatic function test in comparison with the standard SCT...
  22. ncbi Chronic pancreatitis: relation between function and morphology
    S Maartense
    Department of Gastroenterology Hepatology, Leiden University Medical Center P O Box 9600, 2300 RC Leiden, The Netherlands
    Dig Liver Dis 36:61-7. 2004
    ..e. urinary para amino benzoic acid (PABA) recovery and pancreatic polypeptide secretion in response to a meal and glucose tolerance test...
  23. ncbi Vegetarian diet alters the assessment of exocrine pancreatic function with the use of fecal tests
    Jaroslaw Walkowiak
    Institute of Pediatrics, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
    J Pediatr Gastroenterol Nutr 38:224-6. 2004
  24. ncbi Is a 15-minute collection of duodenal secretions after secretin stimulation sufficient to diagnose chronic pancreatitis?
    Peter Draganov
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida 32610 0214, USA
    Pancreas 28:89-92. 2004
    ..A shorter 15-minute collection time has been proposed to increase the feasibility of the secretin stimulation test. The accuracy of this brief collection period for the diagnosis of chronic pancreatitis has not been well defined...
  25. ncbi Screening for pancreatic exocrine insufficiency in patients with diabetes mellitus
    Amadeu C R Nunes
    Department of Gastroenterology, University Hospitals of Coimbra, Avenida Urbano Duarte, Quinta da Estrela, Lote 7, 6o B, Coimbra, Portugal
    Am J Gastroenterol 98:2672-5. 2003
    ..The aim of this study was to screen patients with diabetes mellitus (DM) for pancreatic exocrine insufficiency...
  26. ncbi Variability of fecal pancreatic elastase measurements in cystic fibrosis patients
    I Meyts
    Pediatric Department, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Cyst Fibros 1:265-8. 2002
    ..the fecal pancreatic elastase-1 (EL-1) test is a new non-invasive test for pancreatic function. The aim of the study was to evaluate the intra-patient variability of the fecal EL-1 test in a cystic fibrosis (CF) population...
  27. ncbi Analysis of pancreatic elastase-1 concentrations in duodenal aspirates from healthy subjects and patients with chronic pancreatitis
    Tyler Stevens
    The Pancreas Clinic, Section of Endoscopy, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio 44118, USA
    Dig Dis Sci 49:1405-11. 2004
    ..4) Secretin-stimulated endoscopic function testing with measurement of bicarbonate and PE-1 may provide a simultaneous assessment of both ductal cell and acinar cell function...
  28. ncbi Pancreatic duct after pancreatoduodenectomy: morphologic and functional evaluation with secretin-stimulated MR pancreatography
    Josep Monill
    Department of Radiology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Sant Antoni M Claret 167, Barcelona 08025, Spain
    AJR Am J Roentgenol 183:1267-74. 2004
    ..The purpose of this study was to evaluate the usefulness of secretin-enhanced MR pancreatography in evaluating morphologic changes and pancreatic function after pancreatoduodenectomy...
  29. ncbi The Lundh test and faecal elastase 1 determination in chronic pancreatitis: a comparative study
    C Gredal
    Section of Gastroenterology, Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
    Pancreatology 3:389-94. 2003
    ..The aim of this study was to compare the indirect faecal elastase 1 (FE-1) test with the direct Lundh test in patients with and without definite diagnostic imaging findings...
  30. ncbi Comparison of biologic porcine secretin, synthetic porcine secretin, and synthetic human secretin in pancreatic function testing
    Lehel Somogyi
    Division of Gastroenterology, Department of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Pancreas 27:230-4. 2003
    ..Due to the unavailability of biologic porcine secretin (BPS), 2 synthetic forms of secretin were developed. Our aim is to determine the bioequivalency of the 3 forms of secretin in pancreatic function testing...
  31. ncbi Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice
    Masaki Ohmuraya
    Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Gastroenterology 129:696-705. 2005
    ..Point mutations in the SPINK1 gene seem to predispose humans to pancreatitis; however, the clinical significance of SPINK1 mutations remains controversial. This study aimed to elucidate the role of SPINK1...
  32. ncbi [How much diagnostics in patients with pancreatic cancer?]
    H Bosseckert
    Klinik für Innere Medizin I der Friedrich Schiller Universität Jena
    Zentralbl Chir 128:368-74. 2003
    ..In cases where differentiation is impossible even intraoperatively, we recommend the use of intraoperative fine needle biopsy...
  33. ncbi Exocrine pancreatic insufficiency and its consequences on physical development and metabolism in children and adolescents with type 1 diabetes mellitus
    Martin W Laass
    Children s Hospital, Technical University Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    Eur J Pediatr 163:681-2. 2004
  34. ncbi MRCP-secretin test-guided management of idiopathic recurrent pancreatitis: long-term outcomes
    Pier Alberto Testoni
    Gastroenterology and Gastrointestinal Endoscopy Division, Vita Salute San Raffaele University, Istitutio de Recerca e Cura a Carattere Scientifico, San Raffaele Hospital, Milan, Italy
    Gastrointest Endosc 67:1028-34. 2008
    ..However, ERCP and sphincter of Oddi manometry may be nondiagnostic and postprocedure complications may be frequent...
  35. ncbi Pancreaticoduodenectomy versus Frey's procedure for chronic pancreatitis: preliminary data on outcome and pancreatic function
    Kun Chun Chiang
    Department of General Surgery, Chang Gung Memorial Hospital, 5 Fu Hsing Street, Kwei Shan, Taoyuan, Taiwan
    Surg Today 37:961-6. 2007
    ....
  36. ncbi Comparison of endoscopic ultrasound and endoscopic retrograde pancreatography for the prediction of pancreatic exocrine insufficiency
    Tyler Stevens
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Ave, Desk A31, Cleveland, OH 44195, USA
    Dig Dis Sci 53:1146-51. 2008
    ..Few studies have compared EUS and ERP using an external reference standard. Direct pancreatic function tests (PFT) are an acceptable reference standard for chronic pancreatitis since they detect mild exocrine ..
  37. ncbi Faecal elastase-1: lyophilization of stool samples prevents false low results in diarrhoea
    B Fischer
    Dept. of Medicine 1, , Erlangen, Germany
    Scand J Gastroenterol 36:771-4. 2001
    ..Lyophilization is a simple measure by which to determine elastase-1 independently of stool water content. Lyophilization of stool samples can therefore help to prevent wrong positive elastase-1 test results...
  38. ncbi Nutritional management of cystic fibrosis patients
    Daina Kalnins
    Respiratory Medicine, The Research Institute, Division of Gastroenterology and Nutrition, Department of Pediatrics, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Curr Opin Clin Nutr Metab Care 10:348-54. 2007
    ..We critique recent advances in nutritional care of patients with cystic fibrosis focusing on our understanding of the role of fecal elastase as a pancreatic function test, enzyme replacement therapy and bone health...
  39. ncbi Comparison of the secretin stimulated endoscopic pancreatic function test to retrograde pancreatogram
    Darwin L Conwell
    The Pancreas Clinic, Section of Endoscopy and Pancreaticobiliary Disease, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dig Dis Sci 52:1076-81. 2007
    ..Endoscopic pancreatic function testing may decrease the need for ERCP in patients with chronic abdominal pain...
  40. ncbi [Faecal elastase I--its use in diagnosis of chronic pancreatitis]
    T Krechler
    IV interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 145:480-3. 2006
    ..The Faecal Elastase I occurring in the stool was correlated with the level of the damage of pancreatic tissue together with the control group of the patients with different diagnoses...
  41. ncbi [Does intake of gastric acid pump inhibitor affect the evaluation of the Lundh test?]
    Frank Damborg
    Odense Universitetshospital, medicinsk gastroenterologisk afdeling S
    Ugeskr Laeger 164:4070-3. 2002
    ..The exocrine pancreatic function was evaluated with the Lundh test. The pH was determined in the duodenum, and CCK and secretin were determined in plasma...
  42. ncbi Magnetic resonance hydrometry: non-invasive quantification of the exocrine pancreatic function
    J T Heverhagen
    Klinik für Strahlendiagnostik, Germany
    Rofo 174:291-6. 2002
    ..To show the ability of magnetic resonance hydrometry (MRH) to quantify the pancreatic secretion after secretin stimulation in order to distinguish between physiological excretion and reduced output in chronic pancreatitis...
  43. ncbi Pancreatic enzyme therapy and gastrointestinal symptoms in patients with cystic fibrosis
    Jaroslaw Walkowiak
    J Pediatr 147:870-1. 2005
  44. ncbi Fecal elastase-1 as a test for pancreatic function: a review
    Roberto Dominici
    Istituto di Scienze Biomediche, Ospedale Luigi Sacco, Milano, Italy
    Clin Chem Lab Med 40:325-32. 2002
    ..elastase is unaffected by exogenous pancreatic enzyme treatment, and correlates well with exocrine pancreatic function tests. The measurement of this proteolytic enzyme in stool by means of an enzyme-linked immunosorbent assay (..
  45. ncbi How useful is fecal pancreatic elastase 1 as a marker of exocrine pancreatic disease?
    Satti Beharry
    Department of Pediatrics, The University of Toronto, Ontario, Canada
    J Pediatr 141:84-90. 2002
    ..To evaluate the role of fecal elastase 1 (E1) as a marker of exocrine pancreatic insufficiency (PI)...
  46. ncbi [Chronic pancreatitis. Main symptoms: chronic abdominal pain, weight loss in steatorrhea, secondary diabetes mellitus]
    G Schulthess
    Medizinische Poliklinik, Universitatsspital Zurich
    Praxis (Bern 1994) 94:1139-45. 2005
  47. ncbi Endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA) cytology for diagnosis of chronic pancreatitis
    S Hollerbach
    Dept of Medicine, Knappschaftskrankenhaus, Ruhr University Bochum, Bochum, Germany
    Endoscopy 33:824-31. 2001
    ..inflammation in patients with chronic pancreatitis, using EUS and fine-needle aspiration cytology (EUS-FNA), and to compare the results with those of endoscopic retrograde cholangiopancreatography (ERCP) and pancreatic function tests.
  48. ncbi Modern diagnostics of chronic pancreatitis
    Bernhard Glasbrenner
    Department of Gastroenterology, Endocrinology and Infectious Diseases, St Franziskus Hospital, Hohenzollernring 72, 48145 Münster, Germany
    Eur J Gastroenterol Hepatol 14:935-41. 2002
    ..Imaging procedures, non-invasive or with different degrees of invasiveness, and pancreatic function tests are therefore the diagnostic mainstay in patients with suggestive clinical history...
  49. ncbi Risk factors for recurrent acute alcohol-associated pancreatitis: a prospective analysis
    Hanna Pelli
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 43:614-21. 2008
    ..The aim of this prospective follow-up study was to determine the risk factors associated with recurrences...
  50. pmc Diagnosing exocrine pancreatic insufficiency after surgery: when and which patients to treat
    Helmut Friess
    Department of Surgery, Technical University of Munich Munich, Germany
    HPB (Oxford) 11:7-10. 2009
    ..A variety of direct and indirect pancreatic function tests such as the secretin-cerulein test, the faecal elastase test and the (13)C-mixed triglyceride breath ..
  51. ncbi Evaluation of fecal pancreatic elastase-1 as a measure of pancreatic exocrine function in children with cystic fibrosis
    A Cade
    Regional Paediatric Cystic Fibrosis Unit, St James s University Hospital, Leeds, UK
    Pediatr Pulmonol 29:172-6. 2000
    ..It is stable, unaffected by exogenous pancreatic enzyme treatment, and correlates well with stimulated pancreatic function tests. We report our experience of EL-1 measurements in 142 patients from a large cystic fibrosis (CF) clinic...
  52. ncbi Proteases in the evaluation of pancreatic function and pancreatic disease
    D M Goldberg
    Department of Laboratory Medicine and Pathobiology, University of Toronto, 100 College Street, Toronto, Canada
    Clin Chim Acta 291:201-21. 2000
    ..limitations of tests in different source materials: serum, feces, duodenal aspirate, and non-invasive pancreatic function tests. The practical usefulness of fecal elastase-1 and of fecal chymotrypsin concentrations in diagnosis and ..
  53. ncbi Tests of pancreatic exocrine function - clinical significance in pancreatic and non-pancreatic disorders
    Jutta Keller
    Department of Medicine, Israelitisches Krankenhaus, Hamburg, Germany
    Best Pract Res Clin Gastroenterol 23:425-39. 2009
    ..This review focuses on diagnosis of pancreatic exocrine insufficiency in pancreatic and non-pancreatic disorders...
  54. ncbi Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes
    G W Mills
    School of Clinical Medical Sciences, 4th Floor William Leech Block, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabetologia 47:732-8. 2004
    ..The aim of this study was to measure the heritability estimates for metabolic traits and the features of the insulin resistance syndrome in families with an increased genetic susceptibility to Type 2 diabetes...
  55. ncbi Clinical value of a new fecal elastase test for detection of chronic pancreatitis
    Volker Keim
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Germany
    Clin Lab 49:209-15. 2003
    Several pancreatic function tests exist, but their role in the diagnosis of chronic pancreatitis is controversial. Here we analyzed the clinical value of a newly available fecal elastase assay.
  56. ncbi The effects of morphine-neostigmine and secretin provocation on pancreaticobiliary morphology in healthy subjects: a randomized, double-blind crossover study using serial MRCP
    Abeed H Chowdhury
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    World J Surg 35:2102-9. 2011
    ..The aim of the present study was to use serial MRCP to characterize the effects of morphine-neostigmine and secretin provocation on serum pancreatic enzyme responses and pancreaticobiliary ductal morphology in healthy subjects...
  57. ncbi Quantitative MRCP assessment of pancreatic exocrine reserve and its correlation with faecal elastase-1 in patients with chronic pancreatitis
    R Manfredi
    Istituto di Radiologia, Universita di Verona, Policlinico G B Rossi, Piazzale L A Scuro, 37134, Verona, Italy
    Radiol Med 117:282-92. 2012
    ....
  58. ncbi Acute pancreatitis associated with different combination therapies in patients infected with human immunodeficiency virus
    Jeff J Guo
    College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0004, USA
    Pharmacotherapy 25:1044-54. 2005
    ....
  59. pmc New potential treatments for protection of pancreatic B-cell function in Type 1 diabetes
    S Cernea
    Department of Immunobiology, Yale University, New Haven, CT, USA
    Diabet Med 25:1259-67. 2008
    ....
  60. ncbi Pancreatic enzyme supplement improves dysmotility in chronic pancreatitis patients
    Takaaki Mizushima
    Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan
    J Gastroenterol Hepatol 19:1005-9. 2004
    ..The authors tested whether oral pancreatic enzymes can improve the dysmotility or not...
  61. ncbi Evaluation of a fecal pancreatic elastase-1 enzyme-linked immunosorbent assay: Assessment versus an established assay and implication in classifying pancreatic function
    J Alan Erickson
    ARUP Laboratories, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    Clin Chim Acta 397:87-91. 2008
    ..Disagreement continues regarding 2 fecal pancreatic elastase-1 (PE-1) ELISAs and their respective capabilities to assess pancreatic function...
  62. ncbi Normal pancreatic exocrine function does not exclude MRI/MRCP chronic pancreatitis findings
    Samer Alkaade
    Department of Internal Medicine, Division of Gastroenterology, Saint Louis University SLU, Saint Louis, MO, USA
    J Clin Gastroenterol 42:950-5. 2008
    Abnormal pancreatic function tests have been reported to precede the imaging findings of chronic pancreatitis...
  63. ncbi [Diagnosis and therapy of chronic pancreatitis]
    R Mahlke
    Medizinische Klinik, Städtisches Klinikum Lüneburg
    Internist (Berl) 46:145-56. 2005
    ..Imaging procedures and pancreatic function tests are used to make a diagnosis...
  64. ncbi [Using fat load with medium chain fatty acids as a test for assessing lipid metabolism and exocrine function of the pancreas in patients wits chronic pancreatitis]
    Iu G Chekhonina
    Vopr Pitan 76:9-12. 2007
    ..This makes expedient to include the acids in ration of patients with chronic pancreatitis with the purpose to increase its energy value...
  65. ncbi Corticosteroid-responsive pancreatic cyst found in autoimmune pancreatitis
    Takashi Muraki
    Department of Medicine, Gastroenterology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    J Gastroenterol 40:761-6. 2005
    ....
  66. ncbi [Pancreatic exocrine function in diabetes mellitus. Determination of fecal elastase]
    Carla Mancilla A
    Secciones de Gastroenterología, Departamento de Medicina, Hospital Clinico, Universidad de Chile
    Rev Med Chil 134:407-14. 2006
    ..One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency...
  67. ncbi Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis
    Laszlo Czako
    First Department of Medicine, Semmelweis University, Budapest
    Can J Gastroenterol 17:597-603. 2003
    ..To evaluate the quality of life (QoL) of patients with chronic pancreatitis before and after pancreatic enzyme replacement therapy in a prospective, multicentre, follow-up study...
  68. ncbi Omeprazole, a proton pump inhibitor, improves residual steatorrhoea in cystic fibrosis patients treated with high dose pancreatic enzymes
    Marijke Proesmans
    Department of Paediatrics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 162:760-3. 2003
    ..5-16.5 g/day) to 5.5 g (quartiles 4.9-8.1 g/day) (P<0.01). The same improvement was noted when fat absorption was calculated: 87% (quartiles 81-89%) without versus 94% (quartiles 90-96%) with omeprazole (P<0.001)...
  69. ncbi [Differential therapy of exocrine pancreatic insufficiency--current aspects and future prospects of substitution therapy with pancreatic enzymes]
    C LOser
    I Medizinische Universitätsklinik, Christian Albrechts Universitat Kiel
    Z Gastroenterol 33:715-22. 1995
    ....
  70. ncbi Severe chronic pancreatitis versus suspected pancreatic disease: dynamic MR cholangiopancreatography after secretin stimulation
    R Manfredi
    Department of Radiology, A Gemelli University Hospital, Rome, Italy
    Radiology 214:849-55. 2000
    ..To assess whether secretin stimulation improves visualization of the pancreatic ducts at magnetic resonance (MR) cholangiopancreatography (MRCP) in patients with severe chronic pancreatitis or suspected pancreatic disease...
  71. ncbi Chronic pancreatitis and maldigestion
    John M Petersen
    Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610 0214, USA
    Semin Gastrointest Dis 13:191-9. 2002
    ....
  72. ncbi Evaluation of prognostic factors in patients with acute pancreatitis
    G Brisinda
    Catholic University Hospital Agostino Gemelli, Department of Surgery, Rome, Italy
    Hepatogastroenterology 46:1990-7. 1999
    ....
  73. ncbi Growth hormone therapy for non-islet cell tumor hypoglycemia
    Leticia F G Silveira
    Am J Med 113:255-7. 2002
  74. ncbi Faecal immunoreactive lipase: a simple diagnostic test for cystic fibrosis
    R Münch
    Division of Gastroenterology, University Children s Hospital Zurich, Switzerland
    Eur J Pediatr 157:282-6. 1998
    ..001) increase in a faecal IRL concentration. Faecal IRL concentrations in meconium were very low and of the same magnitude as in patients with CF...
  75. ncbi Clinical usefulness of dual-label Schilling test for pancreatic exocrine function
    W L Chen
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Gastroenterology 96:1337-45. 1989
    ....
  76. ncbi [Autoimmune pancreatitis]
    Terumi Kamisawa
    Nihon Naika Gakkai Zasshi 93:90-5. 2004
  77. ncbi Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction
    Jussi Nikkola
    1School of Medicine, University of Tampere, Tampere, Finland
    Alcohol Alcohol 48:483-6. 2013
    ..To determine the recurrence of pancreatitis and subsequent pancreatic function in patients who stop drinking after the first episode of alcohol-associated pancreatitis...
  78. ncbi Measurement of extra-pancreatic secretory function by 13C-dipeptide breath test
    Yukimoto Ishii
    Department of Digestive Surgery and the Medical Research Center, Division of Genetic and Genomic Research, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Transl Res 149:298-303. 2007
    ..726 (r2=0.527, P<0.0001). The results suggest that this newly developed Bz-Tyr-Ala breath test can quickly and noninvasively diagnose the exocrine pancreatic dysfunction...
  79. ncbi Autoimmune pancreatitis
    Anand Joshi
    Indian J Gastroenterol 24:36; author reply 36-7. 2005
  80. ncbi Use of pancreatic Schilling test to determine efficiency of pancreatic enzyme delivery in pancreatic insufficiency
    W R Brugge
    Northport Veterans Administration Medical Center, New York
    Dig Dis Sci 33:1226-32. 1988
    ....
  81. ncbi Insulin secretory function in type 2 diabetes: Does it matter how you measure it?
    Gerald M Reaven
    Stanford University School of Medicine, California, USA
    J Diabetes 1:142-50. 2009
    ..It is concluded that it may be time to challenge current conventional wisdom as to the role of the β-cell in the natural history of 2DM...
  82. ncbi Post-procedure elevated amylase and lipase levels after double-balloon enteroscopy: relations with the double-balloon technique
    Cengiz Pata
    Department of Gastroenterology, Yeditepe University Medical Faculty, Istanbul, Turkey
    Dig Dis Sci 55:1982-8. 2010
    ..Small elevations of pancreatic enzymes are recently recognized complications of double-balloon enteroscopy (DBE)...
  83. ncbi Pancreatic ductal abnormalities documented by secretin-enhanced MRCP in asymptomatic subjects with chronic pancreatic hyperenzymemia
    Pier Alberto Testoni
    Division of Gastroenterology and Gastrointestinal Endoscopy, Universita Vita Salute San Raffaele, IRCCS San Raffaele Hospital, Milan, Italy
    Am J Gastroenterol 104:1780-6. 2009
    ..The objective of this study was to evaluate pancreatic ductal morphology by secretin-enhanced magnetic resonance cholangiopancreatography (MRCP-S) in subjects with CPH and compare MRCP imaging before and after secretin injection...
  84. ncbi Computed tomography of the brain, hepatotoxic drugs and high alcohol consumption in male alcoholic patients and a random sample from the general male population
    S Mützell
    Department of Family Medicine, University Hospital of Uppsala, Sweden
    Ups J Med Sci 97:183-94. 1992
    ....
  85. ncbi Comparison of endoscopic ultrasound chronic pancreatitis criteria to the endoscopic secretin-stimulated pancreatic function test
    Darwin L Conwell
    Department of Gastroenterology, The Pancreas Clinic, Section of Endoscopy and Pancreaticobiliary Disease, Laboratory Medicine and Biostatistics and Epidemiology and ChiRhoClin, Incorporated, Burtonsville, Maryland, USA
    Dig Dis Sci 52:1206-10. 2007
    ..EUS as a screening test in patients with chronic abdominal pain and equivocal imaging studies may be of limited value...
  86. ncbi Acute pancreatitis: problems in adherence to guidelines
    Tyler Stevens
    Department of Gastroenterology and Hepatology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cleve Clin J Med 76:697-704. 2009
    ..Although evidence-based guidelines on managing acute pancreatitis are available, many physicians are not following them. The authors identify and discuss several problems in adherence to guidelines on testing, imaging, and treatment...
  87. pmc Lack of lipotoxicity effect on {beta}-cell dysfunction in ketosis-prone type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:626-31. 2010
    ..A high FFA level by intralipid infusion for 48 h was not associated with beta-cell decompensation (lipotoxicity) in KPDM patients...
  88. ncbi Novel approaches to the diagnosis of pancreatic disease in childhood
    R T Couper
    University Department of Paediatrics, University of Adelaide, South Australia
    Can J Gastroenterol 11:153-6. 1997
    ..Most of the potentially novel techniques surround organ imaging or molecular biology...
  89. ncbi Low fecal elastase: potentially related to transient small bowel damage resulting from enteric pathogens
    Silvia Salvatore
    Clinica Pediatrica Universitaria, Universita dell Insubria, Varese, Italy
    J Pediatr Gastroenterol Nutr 36:392-6. 2003
    ..However, enteropathy may theoretically cause decreased exocrine pancreatic enzyme secretion through alteration of enteric hormone release...
  90. pmc Higher maternal gestational glucose concentration is associated with lower offspring insulin sensitivity and altered beta-cell function
    Nikki C Bush
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Endocrinol Metab 96:E803-9. 2011
    ..However, studies examining the effects of maternal glucose concentration on measures of insulin sensitivity and β-cell response in prepubertal children are limited...
  91. ncbi Electrolyte composition of endoscopically collected duodenal drainage fluid after synthetic porcine secretin stimulation in healthy subjects
    Tyler Stevens
    The Pancreas Clinic, Section of Endoscopy, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue A30, Cleveland, OH 44118, USA
    Gastrointest Endosc 60:351-5. 2004
    Traditional pancreatic function tests are sensitive for the diagnosis of pancreatic exocrine insufficiency but are cumbersome and difficult to perform...
  92. ncbi Role of ERCP in the management of predicted mild acute biliary pancreatitis
    Yuk Pang Yeung
    Department of Surgery, Kwong Wah Hospital, Kowloon, Hong Kong, China
    Asian J Surg 26:197-201. 2003
    ..This study examined the results of ERCP in patients with predicted mild disease and analysed biochemical and imaging findings in relation to the occurrence of choledocholithiasis...
  93. pmc Pancreatic enzyme therapy
    Joachim Mossner
    Medizinische Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitatsklinikum Leipzig AoR, Liebigstr 20, 04103 Leipzig, Germany
    Dtsch Arztebl Int 108:578-82. 2010
    ..These include chronic pancreatitis, pancreatic cancer, cystic fibrosis, pancreaticocibal asynchrony after gastric or pancreatic surgery, and celiac disease...
  94. ncbi Management of infected pancreatic necrosis
    Mike Larvin
    Division of Surgery, School of Graduate Entry Medicine and Health, University of Nottingham at Derby, Derby City General Hospital, Derby, DE22 3DT, UK
    Curr Gastroenterol Rep 10:107-14. 2008
    ..Although new techniques are still evolving, they should be evaluated against existing standards of treatment...
  95. ncbi Increased insulin secretion and decreased glucose concentrations, but not allostatic load, are associated with stress-related exhaustion in a clinical patient population
    A Sjörs
    Institute of Stress Medicine, Gothenburg, Sweden
    Stress 16:24-33. 2013
    ..The finding of lower plasma glucose concentrations, probably due to higher insulin secretion, in patients with severe stress-related exhaustion, needs to be further investigated, including mechanisms and the clinical relevance...
  96. ncbi Total pancreatectomy combined with partial pancreas autotransplantation for recurrent pancreatic cancer: a case report
    T Kobayashi
    Department of Surgery, Tachikawa General Hospital, Nagaoka, Japan
    Transplant Proc 44:1176-9. 2012
    ..Twenty months after the second operation, the patient is alive without cancer recurrence. The pancreas graft is functioning with a blood glucose of 108 mg/dL, HbA1C of 6.2%, and serum C-peptide of 1.4 ng/mL...
  97. ncbi Update on the diagnosis and treatment of autoimmune pancreatitis
    Amaar H Ghazale
    Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Curr Gastroenterol Rep 10:115-21. 2008
    ..This in turn has resulted in the avoidance of unnecessary surgical procedures for suspected malignancy. This article reviews recent updates in the diagnosis and treatment of autoimmune pancreatitis...
  98. ncbi Secretin MRCP and endoscopic pancreatic manometry in the evaluation of sphincter of Oddi function: a comparative pilot study in patients with idiopathic recurrent pancreatitis
    Alberto Mariani
    Division of Gastroenterology and Gastrointestinal Endoscopy, Department of Radiology, University Vita Salute San Raffaele, IRCCS San Raffaele Hospital, Milan, Italy
    Gastrointest Endosc 58:847-52. 2003
    ..The aim of this study was to compare secretin MRCP and pancreatic sphincter of Oddi manometry for evaluation of sphincter of Oddi function in patients with idiopathic acute recurrent pancreatitis...
  99. pmc Increased serum concentrations of persistent organic pollutants among prediabetic individuals: potential role of altered substrate oxidation patterns
    Kristine Færch
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 97:E1705-13. 2012
    ..There is a need for a better understanding of the potential role of persistent organic pollutants (POPs) in the pathogenesis of type 2 diabetes...
  100. pmc The effect of smoking cessation pharmacotherapies on pancreatic beta cell function
    Amanda K Woynillowicz
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Toxicol Appl Pharmacol 265:122-7. 2012
    ..Therefore whether or not the use of nicotine replacement therapy, varenicline and bupropion can cause endocrine changes which are consistent with impaired pancreatic function warrants further investigation...
  101. ncbi Diagnosis of early chronic pancreatitis by endoscopic ultrasound. Are we there yet?
    Massimo Raimondo
    JOP 5:1-7. 2004
    ..in the presence of 5 or more criteria (out of 9-11) chronic pancreatitis is likely although ERCP and pancreatic function tests may still be normal...

Research Grants11

  1. PANCREATIC LIPASES AND COLIPASE IN LIPOLYSIS AND OBESITY
    Mark Lowe; Fiscal Year: 2007
    ..Taken together the completion of these studies will increase our understanding of fat digestion and the regulation of fat intake. ..
  2. Development of Chronic Pancreatitis Biomarkers
    Teresa A Brentnall; Fiscal Year: 2010
    ..CT scan are the standard approaches for the diagnosis, with endoscopic ultrasound (EUS) combined with pancreatic function tests (PFT) being the most sensitive...
  3. HIV Therapy & Interruption RCT in Resource Poor Clinic
    Luis Montaner; Fiscal Year: 2004
    ..by assessing fat distribution, glucose/insulin metabolism, mineral bone density and liver, kidney and pancreatic function tests. We will also monitor viral resistance outcomes by determining genotypic changes in the HIV-1 protease ..
  4. HIV Therapy & Interruption RCT in Resource Poor Clinic
    Luis J Montaner; Fiscal Year: 2010
    ..by assessing fat distribution, glucose/insulin metabolism, mineral bone density and liver, kidney and pancreatic function tests. We will also monitor viral resistance outcomes by determining genotypic changes in the HIV-1 protease ..
  5. Enhanced RF Tumor Ablation with Liposomal Chemotherapy
    S Goldberg; Fiscal Year: 2008
    ..abstract_text> ..
  6. Integrating the Metabolic and Genetic Faces of Obesity
    Gerald Reaven; Fiscal Year: 2008
    ..We believe that this work will add substantially to the current gap in knowledge regarding the link between obesity and insulin-resistance, and ultimately aid in the development of novel therapeutic targets. ..
  7. Markers of normoglycemic remission in obese diabetics
    Guillermo Umpierrez; Fiscal Year: 2006
    ..Identifying such markers will facilitate and guide future therapeutic interventions and may identify patients at risk to develop chronic complications of diabetes ..
  8. STRUCTURE-FUNCTION ANALYSIS OF COLIPASE AND LIPASE
    Mark Lowe; Fiscal Year: 2005
    ..The results will ultimately permit us to manipulate these interactions for therapeutic purposes. ..
  9. HIV SYNDROME X & PROTEASE INHIBITORS: HUMAN STUDIES
    Gerald Reaven; Fiscal Year: 2004
    ..The results of these studies will help explain why untoward metabolic and clinical events occur with PI treatment, and define the diet most likely to decrease risk of type 2 diabetes and CHD in these patients. ..
  10. Tumor Ablation using Radiofrequency
    S Goldberg; Fiscal Year: 2003
    ..RF tissue heating and coagulation will be compared to determine the best method for increasing RF ablation efficacy in each tumor and tissue model. ..