histocytochemistry

Summary

Summary: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.

Top Publications

  1. pmc Response to treatment in a prospective cohort of patients with large ulcerated lesions suspected to be Buruli Ulcer (Mycobacterium ulcerans disease)
    Kapay Kibadi
    Programme National de Lutte contre l Ulcère de Buruli, Kinshasa, Democratic Republic of the Congo
    PLoS Negl Trop Dis 4:e736. 2010
  2. pmc Evidence for an intramacrophage growth phase of Mycobacterium ulcerans
    Egidio Torrado
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
    Infect Immun 75:977-87. 2007
  3. pmc Evaluation of the increase in permeability of the blood-brain barrier during tumor progression after pulsed focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    Int J Nanomedicine 7:723-30. 2012
  4. pmc Treating glioblastoma multiforme with selective high-dose liposomal doxorubicin chemotherapy induced by repeated focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei Taiwan fyyang ym edu tw
    Int J Nanomedicine 7:965-74. 2012
  5. ncbi High-resolution matrix-assisted laser desorption/ionization imaging of tryptic peptides from tissue
    Yvonne Schober
    Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, Schubertstrasse 60, 35392, Giessen, Germany
    Rapid Commun Mass Spectrom 26:1141-6. 2012
  6. ncbi Histological analysis of 70-nm silica particles-induced chronic toxicity in mice
    Hikaru Nishimori
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Eur J Pharm Biopharm 72:626-9. 2009
  7. ncbi Protein identification by accurate mass matrix-assisted laser desorption/ionization imaging of tryptic peptides
    Yvonne Schober
    Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, Giessen, Germany
    Rapid Commun Mass Spectrom 25:2475-83. 2011
  8. pmc Sequestration and microvascular congestion are associated with coma in human cerebral malaria
    Mark J Ponsford
    Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, United Kingdom
    J Infect Dis 205:663-71. 2012
  9. ncbi Muscle development in mdx mutant mice
    J Dangain
    Muscle Nerve 7:700-4. 1984
  10. pmc Dual-modal tracking of transplanted mesenchymal stem cells after myocardial infarction
    Yefei Li
    Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China
    Int J Nanomedicine 6:815-23. 2011

Research Grants

  1. RETROVIRAL GENE TRANSFER INTO PRIMARY ASTROCYTE
    MARION SHORT; Fiscal Year: 1992
  2. EFFECT OF AGING ON RENAL EPITHELIAL CELLS
    Patricia Wilson; Fiscal Year: 1991
  3. DEMYELINATING DISEASES
    ROBERT KIBLER; Fiscal Year: 1980
  4. Inverted Laser-Scanning Confocal Microscope
    Douglas Taatjes; Fiscal Year: 2004
  5. Noninvasive Quantification of Axon Damage in EAE and MS
    Sheng Kwei Song; Fiscal Year: 2010
  6. A Zeiss LSM 510 Confocal Microscope for Medical Research
    Ruth Montgomery; Fiscal Year: 2004
  7. BIOLOGY OF MONOCROTALINE INDUCED PULMONARY HYPERTENSION
    Dennis Wilson; Fiscal Year: 2005
  8. Fugu Promoters for Mammalian Cortical Neurons
    EDWARD CALLAWAY; Fiscal Year: 2006
  9. VASO-OCCLUSIVE PROCESSES IN SICKLE CELL RETINOPATHY
    Gerard Lutty; Fiscal Year: 2006
  10. Persistent Reservoirs of HIV-1 Infection
    DANIEL FIERER; Fiscal Year: 2006

Detail Information

Publications275 found, 100 shown here

  1. pmc Response to treatment in a prospective cohort of patients with large ulcerated lesions suspected to be Buruli Ulcer (Mycobacterium ulcerans disease)
    Kapay Kibadi
    Programme National de Lutte contre l Ulcère de Buruli, Kinshasa, Democratic Republic of the Congo
    PLoS Negl Trop Dis 4:e736. 2010
    ..We evaluated the effectiveness of this strategy in a series of patients with large ulcers of > or =10 cm in longest diameter in a rural health zone of the Democratic Republic of Congo (DRC)...
  2. pmc Evidence for an intramacrophage growth phase of Mycobacterium ulcerans
    Egidio Torrado
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
    Infect Immun 75:977-87. 2007
    ..The occurrence of an intramacrophage phase is in accordance with the development of cell-mediated and delayed-type hypersensitivity responses in BU patients...
  3. pmc Evaluation of the increase in permeability of the blood-brain barrier during tumor progression after pulsed focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    Int J Nanomedicine 7:723-30. 2012
    ....
  4. pmc Treating glioblastoma multiforme with selective high-dose liposomal doxorubicin chemotherapy induced by repeated focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei Taiwan fyyang ym edu tw
    Int J Nanomedicine 7:965-74. 2012
    ..The present study shows that repeated pulsed high-intensity focused ultrasound (HIFU) can be used to deliver high-dose atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes selectively to brain tumors...
  5. ncbi High-resolution matrix-assisted laser desorption/ionization imaging of tryptic peptides from tissue
    Yvonne Schober
    Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, Schubertstrasse 60, 35392, Giessen, Germany
    Rapid Commun Mass Spectrom 26:1141-6. 2012
    ..The direct detection and identification of proteins on tissue can be hindered by a number of factors including limited mass range and fragmentation efficiency as well as incompatibility with formalin-fixed samples...
  6. ncbi Histological analysis of 70-nm silica particles-induced chronic toxicity in mice
    Hikaru Nishimori
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Eur J Pharm Biopharm 72:626-9. 2009
    ..Thus, liver and spleen appear to be the major target organs for toxicity by the chronic administration of the 70-nm silica particles...
  7. ncbi Protein identification by accurate mass matrix-assisted laser desorption/ionization imaging of tryptic peptides
    Yvonne Schober
    Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, Giessen, Germany
    Rapid Commun Mass Spectrom 25:2475-83. 2011
    ..Results indicate that accurate mass measurements are needed for confident identification and specific image generation of tryptic peptides in tissue sections...
  8. pmc Sequestration and microvascular congestion are associated with coma in human cerebral malaria
    Mark J Ponsford
    Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, United Kingdom
    J Infect Dis 205:663-71. 2012
    ..Increased microvascular congestion accompanies coma in CM, associated with parasite sequestration in the cerebral microvasculature...
  9. ncbi Muscle development in mdx mutant mice
    J Dangain
    Muscle Nerve 7:700-4. 1984
    ..This new mutant therefore presents an interesting case of muscle destruction and rapid regeneration. However, it is not an adequate model for Duchenne muscular dystrophy...
  10. pmc Dual-modal tracking of transplanted mesenchymal stem cells after myocardial infarction
    Yefei Li
    Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China
    Int J Nanomedicine 6:815-23. 2011
    ....
  11. ncbi Pulsed high-intensity focused ultrasound enhances the relative permeability of the blood-tumor barrier in a glioma-bearing rat model
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    IEEE Trans Ultrason Ferroelectr Freq Control 58:964-70. 2011
    ....
  12. pmc Corticosteroid-induced immunosuppression ultimately does not compromise the efficacy of antibiotherapy in murine Mycobacterium ulcerans infection
    Teresa G Martins
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
    PLoS Negl Trop Dis 6:e1925. 2012
    ..Therefore, it is important to clarify if the immune system contributes to bacterial clearance during RS antibiotherapy and if immunosuppression hampers the efficacy of the antibiotic regimen...
  13. ncbi MALDI imaging and profiling MS of higher mass proteins from tissue
    Alexandra van Remoortere
    Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Soc Mass Spectrom 21:1922-9. 2010
    ....
  14. pmc Pathophysiology of the rhesus macaque model for inhalational brucellosis
    Lisa N Henning
    Battelle, Columbus, OH, USA
    Infect Immun 80:298-310. 2012
    ..Thus, the results from this study support the use of the RM as an animal model for inhalational brucellosis to evaluate the efficacy of novel vaccines and therapeutics against B. melitensis...
  15. pmc Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury
    Vaclav Vanecek
    Institute of Experimental Medicine AS CR, Prague, Czech Republic
    Int J Nanomedicine 7:3719-30. 2012
    ..Such magnetic systems with tunable geometric parameters may provide the additional level of control needed to enhance the efficiency of stem cell delivery in spinal cord injury...
  16. ncbi Morphogenesis of salmonid gill poxvirus associated with proliferative gill disease in farmed Atlantic salmon (Salmo salar) in Norway
    Are Nylund
    Department of Biology, University of Bergen, Thormøhlensgt 55, 5020, Bergen, Norway
    Arch Virol 153:1299-309. 2008
    ..However, it is premature to make a taxonomic assignment until the genome of the SGP virus has been sequenced, but morphogenesis clearly shows that this virus is a member of family Poxviridae...
  17. pmc Histopathological changes and clinical responses of Buruli ulcer plaque lesions during chemotherapy: a role for surgical removal of necrotic tissue?
    Marie Therese Ruf
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1334. 2011
    ..During the currently recommended antibiotic treatment with rifampicin/streptomycin plaque lesions tend to ulcerate, often associated with retarded wound healing and prolonged hospital stays...
  18. ncbi High-resolution mapping of neuronal activity by thallium autometallography
    Jürgen Goldschmidt
    Leibniz Institut für Neurobiologie, Akustik Lemen Sprache, Brenneckestr 6, Magdeburg, D 39118 Germany
    Neuroimage 23:638-47. 2004
    ..Clusters of layer Vb pyramidal cells and their apical dendrite bundles are clearly visible in the center of the columns...
  19. pmc Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress
    Saba Naqvi
    Faculty of Engineering and Interdisciplinary Sciences, Jamia Hamdard, Hamdard University, New Delhi, India
    Int J Nanomedicine 5:983-9. 2010
    ..Thus, this study concluded that use of a low optimum concentration of superparamagnetic iron oxide nanoparticles is important for avoidance of oxidative stress-induced cell injury and death...
  20. ncbi The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells
    R Moll
    Cell 31:11-24. 1982
  21. ncbi Photothermal therapy in a murine colon cancer model using near-infrared absorbing gold nanorods
    Glenn P Goodrich
    Nanospectra Biosciences, Incorporated, Houston, Texas 77054, USA
    J Biomed Opt 15:018001. 2010
    ..Elemental analysis indicates nanorod clearance from the blood and retention by the reticuloendothelial system. This study indicates that gold nanorods are promising agents for photothermal ablation of solid tumors...
  22. pmc Identifying pathological biomarkers: histochemistry still ranks high in the omics era
    C Pellicciari
    Department of Biology and Biotechnology, University of Pavia, Italy
    Eur J Histochem 55:e42. 2011
    ..Histochemical techniques thus remain irreplaceable in pathologist's armamentarium, and it may be expected that even in the future histochemistry will keep a leading position among the methodological approaches for clinical pathology...
  23. ncbi Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats
    Chia Pu Lee
    Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan, ROC
    Food Chem Toxicol 45:888-95. 2007
    ....
  24. pmc Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration
    Melissa L Burke
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia
    PLoS Negl Trop Dis 4:e686. 2010
    ....
  25. ncbi Degree of damage to the small bowel and serum antibody titers correlate with clinical presentation of patients with celiac disease
    Juha Taavela
    Pediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
    Clin Gastroenterol Hepatol 11:166-71.e1. 2013
    ..We investigated whether the degree of mucosal damage to the small bowel correlates with clinical presentation and serum markers of celiac disease...
  26. ncbi Structural, functional, and lectin histochemical characteristics of rat ovaries and endometrium in experimental hyper- and hypothyroidism
    Alexander Lutsyk
    Department of Histology and Embryology, Lviv National Medical University, Lviv, Ukraine
    Folia Histochem Cytobiol 50:331-9. 2012
    ....
  27. pmc Infection of swine ex vivo tissues with avian viruses including H7N9 and correlation with glycomic analysis
    Renee W Y Chan
    Department of Pathology, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China Centre of Influenza Research, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Influenza Other Respir Viruses 7:1269-82. 2013
    ..This study analyzed the sialylated N-glycan and O-glycan profile of swine trachea and lung and correlated this with ex-vivo infection of swine explants with avian influenza viruses...
  28. ncbi Theory and practice of combining coagulant fixation and microwave histoprocessing
    M E Boon
    Leiden Cytology and Pathology Laboratory, Leiden, The Netherlands
    Biotech Histochem 83:261-77. 2008
    ..Finally, coagulant fixation is optimal for microwave histoprocessing where ethyl alcohol is followed by isopropanol...
  29. ncbi Three-dimensional engineered bone from bone marrow stromal cells and their autogenous extracellular matrix
    Fatima N Syed-Picard
    Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Tissue Eng Part A 15:187-95. 2009
    ..The resulting engineered tissues are the first 3D bone tissues developed without the use of exogenous scaffolding...
  30. pmc Evaluation of injectable silica-embedded nanohydroxyapatite bone substitute in a rat tibia defect model
    Weiguo Xu
    Institute for Experimental Surgery, University of Rostock, Rostock, Germany
    Int J Nanomedicine 6:1543-52. 2011
    ..In conclusion, SIBS demonstrated a unique structure with osteoinductive and bioresorbable properties, which induced fast bone regeneration. Therefore, a clinical application of SIBS for kyphoplasty is promising...
  31. ncbi Recent progress in histochemistry and cell biology
    Stefan Hübner
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Histochem Cell Biol 137:403-57. 2012
    ....
  32. pmc Histochemical properties of sialic acids and antimicrobial substances in canine anal glands
    T Nara
    Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, Kanagawa, Japan
    Eur J Histochem 55:e29. 2011
    ..The results obtained are discussed with regard to the functional significance of the anal glands. These secretory products may create a defensive barrier against microbial invasion at the anal mucosa...
  33. ncbi Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice
    Hirofumi Kamata
    Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan
    Exp Biol Med (Maywood) 236:315-24. 2011
    ..These results indicate that CBNP can exaggerate BLM-induced inflammatory and fibrotic changes in the lung, suggesting the potential impact of nanoparticles on lung inflammation and fibrosis...
  34. pmc Application of alternative fixatives to formalin in diagnostic pathology
    L Benerini Gatta
    Second Department of Pathology, School of Medicine, University of Brescia, Italy
    Eur J Histochem 56:e12. 2012
    ..The tissues fixed in Bouin did not provide results comparable to those obtained with formalin. The DNA extracted from samples fixed with alternative fixatives was found to be suitable for molecular analysis...
  35. ncbi Glycohistochemistry: the why and how of detection and localization of endogenous lectins
    H J Gabius
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat Munchen, Veterinarstr 13, D 80539 Munchen, Germany
    Anat Histol Embryol 30:3-31. 2001
    ....
  36. ncbi Diagnostic methods current best practices and guidelines for histologic evaluation in infective endocarditis
    Hubert Lepidi
    Unite des Rickettsies CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Infect Dis Clin North Am 16:339-61, ix. 2002
    ..Furthermore, the pathologist may play an important role in identification of previously unknown infectious agents...
  37. ncbi Classification of HER2 receptor status in breast cancer tissues by MALDI imaging mass spectrometry
    Sandra Rauser
    Institute of Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, Neuherberg, Germany
    J Proteome Res 9:1854-63. 2010
    ....
  38. pmc Evaluation of iron oxide nanoparticle biocompatibility
    Amel Hanini
    Interface Traitement, Organisation et Dynamique des Systemes, Universite Paris 7, Paris, France
    Int J Nanomedicine 6:787-94. 2011
    ..In conclusion, γ-Fe(2)O(3) could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications...
  39. ncbi Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines
    Amanda J Law
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 161:1848-55. 2004
    ..There is reasonable neuropathological evidence for a presynaptic pathology but few studies of the postsynaptic component. This study tested the hypothesis that hippocampal dendritic pathology is also present in schizophrenia...
  40. pmc Preliminary biocompatibility investigation of magnetic albumin nanosphere designed as a potential versatile drug delivery system
    Luciana Estevanato
    Instituto de Ciencias Biologicas, Universidade de Brasilia, 70910 900, Brasilia DF, Brazil
    Int J Nanomedicine 6:1709-17. 2011
    ..It is noteworthy that MAN was efficient in treating Ehrlich's tumors by the magnetohyperthermia procedure...
  41. pmc Optimization of the tartrate-resistant acid phosphatase detection by histochemical method
    M J Galvão
    Laboratório de Morfologia Renal, Serviçode Nefrologia, Hospital de Curry Cabral, Lisboa, Portugal
    Eur J Histochem 55:e1. 2011
    ..Our results, allowing an increase in osteoclasts contrast, also support the use of semi-automatic histomorphometric measurements...
  42. ncbi Glycoprofile of the different cell types present in the mucosa of the horse guttural pouches
    F Parillo
    Department of Veterinary Science Faculty of Veterinary Medicine, University of Camerino UNICAM, via circonvallazione 93 95, 62024 Matelica, Italy
    Tissue Cell 41:257-65. 2009
    ..Such diversity of the mucin saccharide residues may be implicated in the binding of macromolecules such as those of bacterial or viral etiology, thus playing a role in the organism's host-defense mechanism in the guttural pouches...
  43. ncbi Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy
    Y Miyagoe
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    FEBS Lett 415:33-9. 1997
    ..In degenerating muscles, considerable amounts of TUNEL positive nuclei were detected as well as DNA laddering, suggesting increased apoptotic cell death was involved in the process of muscle fiber degeneration...
  44. ncbi Transient testicular warming enhances the suppressive effect of testosterone on spermatogenesis in adult cynomolgus monkeys (Macaca fascicularis)
    Yanhe Lue
    Division of Endocrinology and Metabolism, Harbor University of California, Los Angeles Medical Center, Box 446, 1000 West Carson Street, Torrance, CA 90509, USA
    J Clin Endocrinol Metab 91:539-45. 2006
    ..The context of the study was to examine whether combined testosterone (T) and heat (H) treatment have additive or synergistic effects on suppression of spermatogenesis...
  45. pmc Histochemistry through the years, browsing a long-established journal: novelties in traditional subjects
    C Pellicciari
    Dipartimento di Biologia Animale, University of Pavia, Italy
    Eur J Histochem 54:e51. 2010
    ..Some subjects (e.g. histochemistry applied to muscle cells or to mineralized tissues) have recently become rather popular, whereas a wider application of the histochemical approach may be envisaged for plant cells and tissues...
  46. pmc Linguatuliasis in Germany
    Dennis Tappe
    Emerg Infect Dis 12:1034-6. 2006
  47. ncbi Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
    J M Nicholls
    Department of Pathology, University of Hong Kong, Pok Fu Lam Road, Hong Kong SAR, China
    Nat Med 13:147-9. 2007
    ..We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors...
  48. pmc Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice
    Matthew Marks
    Division of Infectious Diseases, Albert Einstein College of Medicine, Forchheimer Bldg, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 75:1586-97. 2007
    ....
  49. pmc Disease signatures are robust across tissues and experiments
    Joel T Dudley
    Stanford Center for Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Mol Syst Biol 5:307. 2009
    ....
  50. ncbi Equine mandibular gland: in situ characterisation of sialoderivatives
    P Scocco
    Department of Environmental Sciences, UNICAM, Matelica, Italy
    Equine Vet J 38:410-5. 2006
    ..Sialic acids modulate the metabolite transport across membranes and may be involved in protection against pathogenic agents. The presence of sialoderivatives in the equine mandibular gland requires further study...
  51. ncbi Lectin binding patterns and carbohydrate mediation of sperm binding to llama oviductal cells in vitro
    Silvana A Apichela
    Instituto Superior de Investigaciones Biológicas CONICET, Química y Farmacia Universidad Nacional de Tucumán, Tucuman, Argentina
    Anim Reprod Sci 118:344-53. 2010
    ..Our results support the idea that more than one carbohydrate could participate in sperm reservoir formation in the llama UTJ oviductal segment...
  52. ncbi Imaging analysis of the brain in a primate model of cerebral malaria
    Satoru Kawai
    Center for Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Tochigi, Japan
    Acta Trop 114:152-6. 2010
    ..This may be one reason why more than half of CM patients have no neurological sequelae following recovery...
  53. ncbi Morphological characterization of the ovary and oocytes vitellogenesis of the tick Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae)
    Patricia Rosa de Oliveira
    Departamento de Biologia, Instituto de Biociencias, UNESP, Av 24 A, no 1515, Cx Postal 199, Rio Claro, SP 13506 900, Brazil
    Exp Parasitol 110:146-56. 2005
    ..They remain attached to the ovary during vitellogenesis by a cellular pedicel and afterwards the mature oocytes (stage V) are released into the ovary lumen...
  54. ncbi Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the Shiverer mouse
    Helen Andrews
    Department of Neurology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Neurosci Res 83:1533-9. 2006
    ..This work contributes to our understanding of the adaptive changes occurring in response to a lack of myelin in a noninflammatory environment similar to the situation seen in chronically demyelinated MS plaques...
  55. ncbi Early cortical lens opacities: a short overview
    Gijs F J M Vrensen
    Department of Ophthalmology, Leiden University Medical Centre, The Netherlands
    Acta Ophthalmol 87:602-10. 2009
    ..In cortical cataracts shear stress between cortex and nucleus during accommodation may also play a significant role...
  56. ncbi Advanced microscopic and histochemical techniques: diagnostic tools in the molecular era of myology
    G Meola
    Dipartimento di Neurologia, Universita di Milano, Policlinico S Donato S Donato Milanese MI Italy
    Eur J Histochem 49:93-6. 2005
    ..These tools improved the diagnostic accuracy and made possible the identification of new changes and structures (Engel and Cunningham, 1963; Scarlato, 1975)...
  57. ncbi Nuclear histochemistry: Its history in fifty volumes
    M G Manfredi Romanini
    Dipartimento di Biologia Animale, University of Pavia, Piazza Botta 10, 27100 Pavia, Italy
    Eur J Histochem 50:79-81. 2006
  58. ncbi Glycosylation at the fetomaternal interface in hemomonochorial placentae from five widely separated species of mammal: is there evidence for convergent evolution?
    Carolyn J P Jones
    Division of Human Development, University of Manchester, St Mary s Hospital, Manchester, UK
    Cells Tissues Organs 185:269-84. 2007
    ..Similar classes of glycan at the hemochorial interface suggest conservation of function. The observed lectin binding patterns suggest broad similarities of glycosylation that may have arisen by convergent evolution...
  59. ncbi The histochemical profile of the rat extensor digitorum longus muscle differentiates after birth and dedifferentiates in senescence
    M Lehnert
    Department of Trauma, Hand, and Reconstructive Surgery, Hospital, J W Goethe University, Theodor Stern Kai, Frankfurt Main, Germany
    Eur J Histochem 51:111-8. 2007
    ..Factors that influence fiber type conversion and thereby motor unit organization may provide a future therapeutic option to enhance the regenerative capacity of motor units...
  60. ncbi Immunopathology of Bartonella vinsonii (berkhoffii) in experimentally infected dogs
    B L Pappalardo
    Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
    Vet Immunol Immunopathol 83:125-47. 2001
    ..vinsonii establishes chronic infection in dogs which may result in immune suppression characterized by defects in monocytic phagocytosis, an impaired subset of CD8+ T lymphocytes, and impaired antigen presentation within LN...
  61. pmc Two patients coinfected with Mycobacterium leprae and human immunodeficiency virus type 1 and naive for antiretroviral therapy who exhibited type 1 leprosy reactions mimicking the immune reconstitution inflammatory syndrome
    M A B Trindade
    Department of Dermatology, Medical School of the University of São Paulo, Rua Cristiano Viana 450, ap 163, São Paulo CEP 05411 000, Brazil
    J Clin Microbiol 44:4616-8. 2006
    ....
  62. pmc First cytochemical study of haemocytes from the crab Carcinus aestuarii (Crustacea, Decapoda)
    V Matozzo
    Department of Biology, University of Padova
    Eur J Histochem 54:e9. 2010
    ..The morphological characterisation of C. aestuarii haemocytes by light microscopy was necessary before performing both ultrastructural and functional studies of circulating cells...
  63. ncbi Histochemistry of glycoconjugates in mucous cells of Salmo trutta uninfected and naturally parasitized with intestinal helminths
    G Bosi
    Department of Veterinary Sciences and Technologies for Food Safety, Faculty of Veterinary Medicine, University of Milan, via Trentacoste n 2, 20134 Milan, Italy
    Dis Aquat Organ 64:45-51. 2005
    ..Our study is the first quantitative report on the effects of intestinal helminths on the density of mucous cells and mucus composition in a fish species...
  64. ncbi Morphology and function of human Leydig cells in vitro. Immunocytochemical and radioimmunological analyses
    Barbara Bilinska
    Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
    Eur J Histochem 53:35-42. 2009
    ..Since the percentage of multinucleate cells was similar in both hCG-stimulated and unstimulated cultures (23.70% and 22.80%), respectively, the appearance of these cell population seems to be independent of hormonal stimulation...
  65. ncbi Histochemical analysis of glycoconjugates in the skin of a catfish (arius tenuispinis, day)
    A Al-Banaw
    Medical Laboratory Sciences Department, Kuwait University, Sulaibekhat, Kuwait
    Anat Histol Embryol 39:42-50. 2010
    ..From these data, we can conclude that the mucus produced by the epidermal goblet cells of A. tenuispinis is rich in mannose, N-acetylgalactosamine and N-acetylglucosamine residues...
  66. pmc Pulmonary abnormalities in mice with paracoccidioidomycosis: a sequential study comparing high resolution computed tomography and pathologic findings
    Damaris Lopera
    Medical and Experimental Mycology Group, Corporacion para Investigaciones Biologicas, Medellin, Colombia
    PLoS Negl Trop Dis 4:e726. 2010
    ..This study focuses on defining patterns, topography and intensity of lung lesions in experimentally infected PCM mice by means of a comparative analysis between High Resolution Computed Tomography (HRCT) and histopathologic parameters...
  67. ncbi Ultrastructural cytochemical analyses of nuclear functional architecture
    S Fakan
    Centre of Electron Microscopy University of Lausanne, Lausanne, Switzerland
    Eur J Histochem 48:5-14. 2004
    ..It attempts to analyse the role of different nuclear structural domains in nuclear functions, as well as further directions in this important field of research...
  68. ncbi Transitions of muscle fiber phenotypic profiles
    D Pette
    Fachbereich Biologie, , 78547 Konstanz, Germany
    Histochem Cell Biol 115:359-72. 2001
    ..This brief review summarizes our current understanding of the delineation of fiber types, modulations of their phenotypic profiles as induced under various conditions, and potential mechanisms involved in these transitions...
  69. ncbi Zearalenone induces male germ cell apoptosis in rats
    Il Hwan Kim
    Korea Institute of Toxicology, PO Box 123, 100 Jang Dong, Yuseong Gu, Daejeon 305 600, South Korea
    Toxicol Lett 138:185-92. 2003
    ..This study has established that apoptosis is the principal mechanism contributing to germ cell depletion and testicular atrophy following ZEA exposure...
  70. ncbi The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 70:398-407. 2004
    ..These findings emphasize the importance of treating malaria in pregnancy promptly with effective antimalarial drugs...
  71. ncbi The functional architecture of the nucleus as analysed by ultrastructural cytochemistry
    Stanislav Fakan
    Centre of Electron Microscopy, University of Lausanne, Rue du Bugnon 27, 1005, Lausanne, Switzerland
    Histochem Cell Biol 122:83-93. 2004
    ..Finally, it attempts to critically evaluate some future applications of ultrastructural investigations of the nucleus and stresses the importance of combining them with light microscopic analyses of living cells...
  72. ncbi Hematology, morphology, cytochemical staining, and ultrastuctural characteristics of blood cells in king cobras (Ophiophagus hannah)
    Chaleow Salakij
    Faculty of Veterinary Medicine, Kasetsart University, Kamphaengsaen Nakorn Pathom, Thailand
    Vet Clin Pathol 31:116-26. 2002
    ..Hematologic tests would be useful for evaluating the health of the snakes, however, basic hematologic data and morphology have not been described for this species...
  73. ncbi Ageing of the human oviduct: lectin histochemistry
    G Gheri
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Italy
    Histol Histopathol 16:21-8. 2001
    ..Moreover, PNA reactive material was present at the free border of the ciliated and non-ciliated cells. The latter findings were statistically confirmed and could be considered strictly related to the ageing process...
  74. pmc Specialised cell types in the chorioallantoic membrane express carbonic anhydrase during chick embryogenesis
    M G Gabrielli
    Department of Comparative Morphological and Biochemical Sciences, University of Camerino, Italy
    J Anat 198:229-38. 2001
    ....
  75. ncbi The tidemark of the chondro-osseous junction of the normal human knee joint
    T J Lyons
    Newcastle Department of Forensic Medicine, NSW, Australia
    J Mol Histol 36:207-15. 2005
    ..From all of these results it is clear that this part of the chondro-osseous junctional region is chemically more complex and distinctive than has previously been described...
  76. ncbi Glycan localization within the human interphotoreceptor matrix and photoreceptor inner and outer segments
    P N Bishop
    Department of Ophthalmology, University of Manchester, UK
    Glycobiology 3:403-12. 1993
    ....
  77. ncbi Regional neuropathology following kainic acid intoxication in adult and aged C57BL/6J mice
    Stanley Anthony Benkovic
    Toxicology and Molecular Biology Branch, Centers for Disease Control and Prevention National Institute for Occupational, Safety and Health, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Brain Res 1070:215-31. 2006
    ..Our data indicate widespread neurotoxicity following kainic acid treatment in C57BL/6J mice, and reveal increased sensitivity to this excitotoxicant in aged animals...
  78. ncbi Disruption of erythrocytes distinguishes fixed cells/tissues from viable cells/tissues following microwave coagulation therapy
    Tsuyoshi Yamaguchi
    Department of Surgery, Shiga University of Medical Science, Seta tsukinowa cho, Ohtsu, Shiga, 520 2192, Japan
    Dig Dis Sci 50:1347-55. 2005
    ..Disruption of erythrocytes on HE staining is an interesting and important diagnostic clue in distinguishing nonviable fixed tissues from viable tissues following MCT...
  79. ncbi A histochemical and immunohistochemical investigation of guanase and nedasin in rat and human tissues
    Katsutaka Sannomiya
    Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
    J Med Invest 53:246-54. 2006
    ..Based upon the research reports to date, the experiments on guanase and nedasin in rat organs performed in this study are considered to have important implications in the investigation of their physiological significance...
  80. ncbi Neuronal activation of Ras regulates synaptic connectivity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, D 04109 Leipzig, Germany
    Eur J Neurosci 19:2953-66. 2004
    ..We conclude that neuronal Ras is a common switch of plasticity in adult mammalian brain sculpturing neuronal architecture and synaptic connectivity in concert with tuning synaptic efficacy...
  81. ncbi Site-specific localization of two distinct phosphatases along the osteoblast plasma membrane: tissue non-specific alkaline phosphatase and plasma membrane calcium ATPase
    Yukiko Nakano
    Biostructural Science, Graduate School of Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8549, Japan
    Bone 35:1077-85. 2004
    ..These data suggest the presence of a phosphatase different from TNSALP, most plausibly PMCA, on the osteoidal surface of osteoblasts...
  82. ncbi 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors
    J J Schimmel
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Brain Res Mol Brain Res 74:1-14. 1999
    ....
  83. ncbi Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection
    Mei Xu
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Brain Res 1055:137-42. 2005
    ..These results suggest that oxidative stress is involved in the degeneration of the lesioned ND neurons; whereas constitutive antioxidant enzymes may protect the RN neurons from oxidative damage...
  84. ncbi The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study
    Semiha Noyan
    Department of Histology and Embryology, Uludag University Faculty of Medicine, 16059, Gorukle, Bursa, Turkey
    Acta Histochem 107:421-34. 2006
    ..We conclude that vitamin A has potential for the treatment of hepatic fibrotic diseases. Alpha-SMA immunohistochemistry was found to be more informative than desmin immunohistochemistry for monitoring liver fibrosis...
  85. ncbi FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte
    E F Eppens
    Department of Experimental Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    J Hepatol 35:436-43. 2001
    ..Here we examined the subcellular localization of this protein within the liver...
  86. ncbi Comparison analysis of distributions of tyrosine hydroxylase, calmodulin and calcium/calmodulin-dependent protein kinase II in a triple stained slice of rat brain
    Den etsu Sutoo
    Institute of Medical Science, University of Tsukuba, Tsukuba 305 8575, Japan
    Brain Res 933:1-11. 2002
    ....
  87. ncbi Structural differences in the enteric neural network in murine colon: impact on electrophysiology
    Andrei Sibaev
    Department of Internal Medicine II, Gastrointestinal Physiology GAP, Technical University of Munich, 81675 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 285:G1325-34. 2003
    ..In summary, in the murine and rat proximal colon, a constant and distinct hypoganglionic region is described with important concomitant changes in local electrophysiology...
  88. ncbi Mild hypoxic preconditioning attenuates injury-induced NADPH-d/nNOS expression in brainstem motor neurons of adult rats
    I Hua Wei
    Department of Anatomy and Cell Biology, College of Medicine, China Medical University, Taichung, Taiwan
    J Chem Neuroanat 35:123-32. 2008
    ..The MHPC treatment might induce minute amounts of NO to alter the state of milieu of the experimental animals to protect against the PNCI...
  89. ncbi A simple contrast enhancement by potassium permanganate oxidation for Lowicryl K4M ultrathin sections prepared by high pressure freezing/freeze substitution
    A Sawaguchi
    Department of Anatomy, Central Research Laboratories, Miyazaki Medical College, Miyazaki, Japan
    J Microsc 201:77-83. 2001
    ....
  90. ncbi Use of frozen biologic material for combined light and electron microscopy
    I M Vogels
    Laboratory of Cell Biology and Histology, University of Amsterdam, Academic Medical Centre, The Netherlands
    Ultrastruct Pathol 17:537-46. 1993
    ....
  91. ncbi Development of the cyto- and chemoarchitectural organization of the rat nucleus of the solitary tract
    L L Zhang
    School of Anatomy, The University of New South Wales, Sydney, Australia
    Anat Embryol (Berl) 203:265-82. 2001
    ....
  92. ncbi Whole mount enzyme histochemistry as a rapid screen at necropsy for expression of beta-galactosidase (LacZ)-bearing transgenes: considerations for separating specific LacZ activity from nonspecific (endogenous) galactosidase activity
    Brad Bolon
    GEMpath Inc, Cedar City, Utah 84720 8400, USA
    Toxicol Pathol 36:265-76. 2008
    ....
  93. ncbi Differential histochemical localization patterns of reduced nicotinamide adenine dinucleotide phosphate-diaphorase and neuronal nitric oxide synthase during postnatal development of the rat vomeronasal organ
    Fumio Nasu
    Department of Histology and Oral Histology, The University of Tokushima School of Dentistry, 3 18 15 Kuramoto, Tokushima 770 8504, Japan
    Histochem Cell Biol 118:473-7. 2002
    ..Moreover, it was found that NADPH-d and neuronal NOS are not colocalized in the sensory epithelium of the developing rat vomeronasal organ...
  94. pmc Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin
    A A Hack
    Department of Molecular Genetics and Cell Biology, Section of Cardiology, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biol 142:1279-87. 1998
    ..As a common molecular feature in a variety of muscular dystrophies, sarcoglycan loss is a likely mediator of pathology...
  95. ncbi Hepatic clearance of apoptotic lymphocytes: simply removal of waste cells?
    A Chionna
    Dept of Biological and Environmental Science and Technology, University of Lecce, Italy
    Eur J Histochem 47:97-104. 2003
    ..e. rat lymphocytes and rat liver). Moreover, the drastically reduced efficiency of recognition of human or mouse apoptotic lymphocytes when injected into rat liver, suggested the involvement also of species-specific antigens...
  96. ncbi Beta-galactosidase staining on bone marrow. The osteoclast pitfall
    H G Kopp
    Department of Genetic Medicine, Howard Hughes Medical Institute, Weill Medical College of Cornell University, New York, New York, USA
    Histol Histopathol 22:971-6. 2007
    ..Specifically, beta-galactosidase positive hematopoietic or stromal cells should be proven specifically not to be osteoclasts by co-staining or staining adjacent sections for specific markers of hematopoietic and stromal cells...
  97. ncbi Combined histochemical staining, RNA amplification, regional, and single cell cDNA analysis within the hippocampus
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, NY, USA
    Lab Invest 84:952-62. 2004
    ....
  98. ncbi Clomiphene citrate modulates the expression of endometrial carbohydrates (especially N-acetyl-d-glucosamine and sialic acid) in pseudopregnant rats
    T Khoza
    School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Theriogenology 70:612-21. 2008
    ..The results suggest that the effect of CC on the expression of N-acetyl-d-glucosamine and sialic acid is a significant reason why there are low pregnancy rates with CC use...
  99. ncbi Lectin cytochemistry of rat cerebral and cerebellar neuronal cells
    K Kawai
    Department of Neuropsychiatry, Okayama University Medical School, Japan
    Neuropathology 21:13-8. 2001
    ..Reactivity with GSL-I, GSL-II, VVA and PHA-L was observed only on the neuronal cell surface. The present findings demonstrate the differences between cerebral and cerebellar neurons in reacting with glycoconjugates...
  100. ncbi Importance of N-linked sugar residues in the development of Auerbach's plexus in the rat colon: a lectin histochemical study
    Hiroyuki Tanaka
    Department of Pediatric Surgery, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Histochem J 34:111-6. 2002
    ..N-linked oligosaccharides may thus play important roles in the development and maturation of the Auerbach's plexus, and may be involved in the developmental defect of the plexus, e.g. as occurs in Hirschsprung's disease...
  101. pmc Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
    A Yachie
    Department of Laboratory Sciences, School of Health Sciences, Kanazawa University, Japan
    J Clin Invest 103:129-35. 1999
    ..This study presents not only the first human case of HO-1 deficiency but may also provide clues to the key roles played by this important enzyme in vivo...

Research Grants63

  1. RETROVIRAL GENE TRANSFER INTO PRIMARY ASTROCYTE
    MARION SHORT; Fiscal Year: 1992
    ..Animals will be studies for cellular expression of B-gal and B-NGF by histocytochemistry and immunocytochemistry, respectively, as well as by in situ hybridization histochemistry...
  2. EFFECT OF AGING ON RENAL EPITHELIAL CELLS
    Patricia Wilson; Fiscal Year: 1991
    ..microscopy, assessment of DNA synthesis (3H-thymidine uptake) and Na-K ATPase activity (3H-ouabain binding), histocytochemistry and determination of the effect of pertussis and cholera toxins and forskolin on adenylate cyclase activity...
  3. DEMYELINATING DISEASES
    ROBERT KIBLER; Fiscal Year: 1980
    ..The specific aims are to isolate the enzyme and to localize it in CNS tissues by the technique of EM histocytochemistry. A second aim is to identify a physiological substrate of the enzyme.
  4. Inverted Laser-Scanning Confocal Microscope
    Douglas Taatjes; Fiscal Year: 2004
    ..It will also afford the capacity for advanced high-quality imaging capabilities and ensure sustained and efficient use for the UVM biomedical research community for the future. ..
  5. Noninvasive Quantification of Axon Damage in EAE and MS
    Sheng Kwei Song; Fiscal Year: 2010
    ..In both strains, the extent of axonal damage will closely relate to the duration of the acute peaking of neurological deficits - presumably caused by acute inflammatory responses. ..
  6. A Zeiss LSM 510 Confocal Microscope for Medical Research
    Ruth Montgomery; Fiscal Year: 2004
    ..Thus this confocal microscope would be the basis of a core facility to assure that these investigators will have adequate access to state-of-the-art imaging techniques. ..
  7. BIOLOGY OF MONOCROTALINE INDUCED PULMONARY HYPERTENSION
    Dennis Wilson; Fiscal Year: 2005
    ..abstract_text> ..
  8. Fugu Promoters for Mammalian Cortical Neurons
    EDWARD CALLAWAY; Fiscal Year: 2006
    ..Small capacity viruses are also among the most promising vectors presently available for human gene therapy in the brain, and their eventual use for this purpose will also require effective short promoters. ..
  9. VASO-OCCLUSIVE PROCESSES IN SICKLE CELL RETINOPATHY
    Gerard Lutty; Fiscal Year: 2006
    ..abstract_text> ..
  10. Persistent Reservoirs of HIV-1 Infection
    DANIEL FIERER; Fiscal Year: 2006
    ..These studies will also provide me with the opportunity to develop the required skills to reach my long-term goal: a career as an independent investigator and academician performing patient-oriented translational research...
  11. In vivo Substrate Utilization in the Newborn Rat Brain
    Raghavendra Rao; Fiscal Year: 2006
    ....
  12. Joint degeneration: Somatic mosaic analysis in a transgenic mouse
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. OAMiner: Integrative Knowledge Anchored Hypothesis Discovery
    METIN NAFI GURCAN; Fiscal Year: 2010
    ..g. quality of life, psychological, strength and performance measures) data;and 4) computerized-image analysis derived features (e.g. cross-sectional area of the quadriceps). ..
  14. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  15. Imaging tumor associated fibroblast activation protein
    Ching Hsuan Tung; Fiscal Year: 2008
    ..We believe that the developed approach can be used as a platform to design a broad spectrum of activatable molecular probes to image other amino peptidases in vivo. ..
  16. MECHANISMS OF NEURONAL APOPTOSIS IN VIVO
    Lee Martin; Fiscal Year: 2009
    ..This work can define a new mitochondrial mechanism for target deprivation-induced neurodegeneration and can improve the understanding of the cellular and molecular mechanisms of neuronal apoptosis in vivo ..
  17. Does peripheral localized chronic inflammation predispose to neurodegeneration?
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2002
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..
  19. NEURONAL FUNCTION IN CRANIOFACIAL DEVELOPMENT
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..abstract_text> ..
  20. Microporidiosis in AIDS
    ELIZABETH DIDIER; Fiscal Year: 2004
    ..This model will provide a better understanding of how the immune response functions to control microsporidia that replicate in different sites within a host cell. ..
  21. RHESUS MACAQUE MODEL OF TUBERCULOSIS
    DAVID LEWINSOHN; Fiscal Year: 2001
    ..g., CT scans, quantitative culture of mycobacteria from BAL fluids and liver biopsies) which correlate with survival. ..
  22. T Cell Immunity & Liver Fibrosis in HCV/HIV Coinfection
    Chihiro Morishima; Fiscal Year: 2003
    ..Finally, we will test the hypotheses that HCV/HIV coinfected subjects treated with HAART will demonstrate improved HCV-specific CD4+ T cell function that is not fibrogenic, and is sequestered to the liver. ..
  23. In Situ Detection of Host-Spirochete Interaction by Iso*
    Ruth Montgomery; Fiscal Year: 2002
    ..burgdorferi. In summary, this proposal employs a novel and powerful technique to address several possible mechanisms of spirochetal evasion of the immune system. ..
  24. Defining Cell Lineages in the Bladder Urothelium
    Sabina Signoretti; Fiscal Year: 2006
    ..These studies will clarify lineage relationships among bladder epithelial cells and provide important insights into the nature of urothelial stem cells. ..
  25. Natural antimicrobials against bacterial vaginosis
    Michael Chikindas; Fiscal Year: 2006
    ..Our research will lead to a new approach for BV prophylaxis and treatment. ..
  26. Gene therapy for treatment of craniofacial dysplasia
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..Completion of this study will aid in the development of novel therapies for the management of genetic disorders. ..
  27. Mechanisms of Motor Neuron Death
    Lee Martin; Fiscal Year: 2006
    ..abstract_text> ..
  28. Mechanism of Vector Saliva Inhibition of Innate Immunity
    Ruth Montgomery; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATION
    Scott Miller; Fiscal Year: 2008
    ..Because the pharmacology and toxicology of PACA chelators, such as DTPA and EDTA, are quite well understood, the development pathway of the related TT- based chelators may proceed rapidly. ..
  30. T Cell Response to Dengue Virus
    Sujan Shresta; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  31. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..Frequent consultation with a neurosurgeon, who is a member of the research team, will provide necessary input to direct the study and experiments towards clinically relevant solutions for transection nerve injuries. ..
  32. IN VIVO REGULATION OF IL6 AND IL6R GENE EXPRESSION
    CHARLES O BRIEN; Fiscal Year: 2002
    ..Finally, cis-acting regulatory elements in the IL-6 promoter that are the targets for estrogen and PTH actions in vivo will be identified. ..
  33. NEUROANATOMY OF THE AUDITORY SYSTEM
    Nell B Cant; Fiscal Year: 2010
    ..Detailed understanding of these connections will contribute to the development of rational, testable hypotheses about auditory function in both health and disease. ..
  34. COMPARATIVE MEDICAL SCIENTIST POSTDOCTORAL TRAINING
    Trenton Schoeb; Fiscal Year: 2006
    ..abstract_text> ..
  35. Recombinant FIV vectors for the delivery of siRNA therapy to joints
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. Arp2/3 mRNA localization and directional cell migration
    Gang Liu; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  37. TRANCE REGULATION OF CHONDROCYTE MATURATION
    PAUL ODGREN; Fiscal Year: 2005
    ..Epiphyseal chondrodysplasias or other defects in bone growth (limb or facial deformities) and metabolism may be impacted if new potential points for pharmacological or gene therapy interventions are discovered. ..
  38. Novel optical probes fir in vivo imaging
    Ching Hsuan Tung; Fiscal Year: 2006
    ..abstract_text> ..
  39. SACRAL CREST CELLS AND ENTERIC NEURODEVELOPMENT
    Raj Kapur; Fiscal Year: 2005
    ..The results of this study will further our understanding of normal enteric neurodevelopment and congenital disorders of intestinal motility. ..
  40. SYNAPTIC ORGANIZATION OF THE BASOLATERAL AMYGDALA
    ALEXANDER MCDONALD; Fiscal Year: 2008
    ..abstract_text> ..
  41. The Choriocapillaris in Aging and Macular Disease
    Robert Mullins; Fiscal Year: 2005
    ..These experiments are expected to provide novel insights into the potential role of the choriocapillaris in the pathobiology of AMD. ..
  42. IGF-1 in neocortical development and plasticity
    David Riddle; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  43. Does Hyperglycemia Predict Pancreatic Cancer Diagnosis?
    Suresh Chari; Fiscal Year: 2006
    ..The research described in this application is 100% relevant to pancreatic cancer. ..
  44. Quantitative molecular imaging in articular cartilage
    Yang Xia; Fiscal Year: 2009
    ....
  45. Loci Affecting Colon Cancer Susceptibility
    Rosemary Elliott; Fiscal Year: 2008
    ..In the third aim we will address the question of what genetic changes occur in the tumors themselves, and whether there is specificity such that tumors arising from any one of the congenic strains show a consistent profile of changes. ..
  46. Axon Regeneration after Spinal Cord Injury in Mice
    Oswald Steward; Fiscal Year: 2009
    ..Together, these studies will provide a critical data base regarding the growth capacity of cortico-spinal tract axons in mice, which will be essential for future studies involving genetically modified mice. ..
  47. DNA Damage/Repair and Cell Death
    Lee Martin; Fiscal Year: 2009
    ....
  48. TLR5 and Pulmonary Innate Immunity
    THOMAS HAWN; Fiscal Year: 2009
    ..The immunogenetic models derived from these studies will illuminate the molecular basis of why individuals have different susceptibility to flagellated bacterial infections and hopefully culminate in novel insights for future therapies. ..
  49. Toll-like Receptors and the Innate Immune Response
    THOMAS HAWN; Fiscal Year: 2003
    ..tuberculosis and L. major will reveal novel insights about innate immunity and infectious diseases that will have implications for vaccine development. ..
  50. MECHANISMS OF SKELETAL RECONSTITUTION AFTER LACTATION
    Scott Miller; Fiscal Year: 2004
    ..abstract_text> ..
  51. Granulocytic Ehrlichiosis: Cell-Pathogen Interactions
    Dori Borjesson; Fiscal Year: 2005
    ..Currently, the candidate is a junior faculty member at a strong research institution with a clear mandate and desire to pursue an independent research program. ..
  52. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  53. Multiphoton Confocal Microscopy System
    EDWARD CALLAWAY; Fiscal Year: 2006
    ..These studies are only possible with the use of a multiphoton confocal microscopy system [unreadable] [unreadable] [unreadable]..
  54. PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53
    Kim Boekelheide; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. PRESERVATION OF GENETIC LINES IN A NON MAMMALIAN SYSTEM
    Mary Hagedorn; Fiscal Year: 2005
    ..Most importantly, these somatic changes will not affect the germ line, so they are ideal for genomic banking to maintain important genetic stocks for biomedical and endangered fish research. ..
  56. Technology and Endothelial Biology of Kidney Injury Molecule-1
    Vishal Vaidya; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  57. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURY
    Kim Boekelheide; Fiscal Year: 2003
    ..Together, these complimentary approaches will elucidate the key molecular mechanisms responsible for irreversible testicular injury. ..
  59. Cytoplasmic Reactivation of p53 Family Members
    Charles Walker; Fiscal Year: 2004
    ..Overexpression might overwhelm mechanisms that sequester these proteins in the cytoplasm of leukemic clam hemocytes and lead to a resumption of clam p53 and/or p63/73-induced apoptosis. ..
  60. SERTOLI CELL TOXICITY IN VIVO--MICROTUBULE DISRUPTION
    Kim Boekelheide; Fiscal Year: 2001
    ..Together, these complimentary approaches will critically examine key steps in the pathogenetic sequence by which microtubule disrupters alter the supportive capacity of Sertoli cells resulting in loss of germ cells and infertility. ..
  61. Prognostic Significance of Actuvated Akt/PKB in Cancer
    Odile David; Fiscal Year: 2009
    ..The Tulane/LSU General Clinical Research Center, including the GCRC Core Laboratory, will serve as the primary ..