Genomes and Genes
microbial sensitivity tests
Summary: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Publications319 found, 100 shown here
- Rapid molecular detection of tuberculosis and rifampin resistanceCatharina C Boehme
Foundation for Innovative New Diagnostics, Geneva, Switzerland
N Engl J Med 363:1005-15. 2010..Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect...
- Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistanceA P Magiorakos
European Centre for Disease Prevention and Control, Stockholm, Sweden
Clin Microbiol Infect 18:268-81. 2012....
- Epidemiology of invasive candidiasis: a persistent public health problemM A Pfaller
Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Clin Microbiol Rev 20:133-63. 2007..Further research to improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC...
- Acinetobacter baumannii: emergence of a successful pathogenAnton Y Peleg
Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
Clin Microbiol Rev 21:538-82. 2008....
- Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from IndiaDongeun Yong
Yonsei University College of Medicine, Research Institute of Antimicrobial Resistance, Seoul, Republic of Korea
Antimicrob Agents Chemother 53:5046-54. 2009..The broad resistance carried on these plasmids is a further worrying development for India, which already has high levels of antibiotic resistance...
- Antibiotics for emerging pathogensMichael A Fischbach
Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Science 325:1089-93. 2009....
- Antimicrobial effects of silver nanoparticlesJun Sung Kim
Laboratory of Toxicology, Seoul National University, Seoul, Korea
Nanomedicine 3:95-101. 2007..These results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems...
- Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substancesIrith Wiegand
Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall Research Station, Vancouver, British Columbia, V6T 1Z4, Canada
Nat Protoc 3:163-75. 2008..Growth is assessed after incubation for a defined period of time (16-20 h) and the MIC value is read. This protocol applies only to aerobic bacteria and can be completed in 3 d...
- Determination of minimum inhibitory concentrationsJ M Andrews
Department of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK
J Antimicrob Chemother 48:5-16. 2001..Tables giving expected MIC ranges for control NCTC and ATCC strains are also supplied...
- An increasing threat in hospitals: multidrug-resistant Acinetobacter baumanniiLenie Dijkshoorn
Department of Infectious Diseases C5 P, Leiden University Medical Centre, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
Nat Rev Microbiol 5:939-51. 2007..Here, we present an overview of the current knowledge of the genus Acinetobacter, with the emphasis on the clinically most important species, Acinetobacter baumannii...
- Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesisMichael A Kohanski
Howard Hughes Medical Institute, Boston University, Boston, MA 02215, USA
Mol Cell 37:311-20. 2010..This work establishes a radical-based molecular mechanism whereby sublethal levels of antibiotics can lead to multidrug resistance, which has important implications for the widespread use and misuse of antibiotics...
- Essential oils: their antibacterial properties and potential applications in foods--a reviewSara Burt
Department of Public Health and Food Safety, Faculty of Veterinary Medicine, University of Utrecht, P O Box 80175, 3508 TD Utrecht, The Netherlands
Int J Food Microbiol 94:223-53. 2004..Some EO components are legally registered flavourings in the EU and the USA. Undesirable organoleptic effects can be limited by careful selection of EOs according to the type of food...
- An epidemic, toxin gene-variant strain of Clostridium difficileL Clifford McDonald
Epidemiology and Laboratory Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 353:2433-41. 2005..difficile with increased virulence, resistance, or both...
- Multidrug-resistance efflux pumps - not just for resistanceLaura J V Piddock
Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
Nat Rev Microbiol 4:629-36. 2006..Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them...
- Biological effects of essential oils--a reviewF Bakkali
Institut Curie Section de Recherche, UMR2027 CNRS IC, LCR V28 CEA, Bat 110, Centre Universitaire, 91405 Orsay Cedex, France Université Abdelmalek Essâadi, Faculte des Sciences, Laboratoire de Biologie et Santé, BP 2121, Tetouan, Morocco
Food Chem Toxicol 46:446-75. 2008..These findings suggest that, at least in part, the encountered beneficial effects of essential oils are due to prooxidant effects on the cellular level...
- Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national databaseLinda K McDougal
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 41:5113-20. 2003..Noticeably absent from the U.S. database were isolates with the previously described Brazilian and EMRSA15 PFGE patterns. These data suggest that there are a limited number of ORSA genotypes present in the United States...
- Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coliIris Keren
Department of Biology, Northeastern University, 134 Mugar Hall, 360 Huntington Ave, Boston, MA 02115
J Bacteriol 186:8172-80. 2004..The function of these specialized dormant cells is to ensure the survival of the population in the presence of lethal factors...
- Extended-spectrum beta-lactamases: a clinical updateDavid L Paterson
Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Clin Microbiol Rev 18:657-86. 2005..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
- A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosisKoen Andries
Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
Science 307:223-7. 2005..Plasma levels associated with efficacy in mice were well tolerated in healthy human volunteers. Mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase...
- Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infectionTimothy S Naimi
Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
JAMA 290:2976-84. 2003..However, MRSA has emerged in patients without established risk factors (community-associated MRSA)...
- Bacterial charity work leads to population-wide resistanceHenry H Lee
Howard Hughes Medical Institute, Center for BioDynamics, Boston, Massachusetts 02115, USA
Nature 467:82-5. 2010....
- Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursorM Zasloff
Proc Natl Acad Sci U S A 84:5449-53. 1987..The sequence of a partial cDNA of the precursor reveals that both peptides derive from a common larger protein. These peptides appear to represent a previously unrecognized class of vertebrate antimicrobial activities...
- Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'Paul Cos
Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
J Ethnopharmacol 106:290-302. 2006....
- Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKRBenjamin P Howden
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
PLoS Pathog 7:e1002359. 2011..aureus infections and demonstrates the role played by walKR to increase drug resistance, control metabolism and alter the virulence potential of this pathogen...
- Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial SurveillancD J Diekema
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Clin Infect Dis 32:S114-32. 2001..Given the increasing multidrug resistance among staphylococci and the possible emergence of vancomycin-resistant strains, global strategies are needed to control emergence and spread of multiply resistant staphylococci...
- Alarming β-lactamase-mediated resistance in multidrug-resistant EnterobacteriaceaeKaren Bush
Biology Department, Indiana University Bloomington, Bloomington, IN 47405, USA
Curr Opin Microbiol 13:558-64. 2010..These enzymes are now appearing in multiple combinations of ESBLs and carbapenemases, thereby conferring resistance to virtually all β-lactam antibiotics...
- Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variationEliana Drenkard
Department of Genetics, Harvard Medical School, Massahusetts General Hospital, Boston, MA 02114, USA
Nature 416:740-3. 2002..Compounds that affect PvrR function could have an important role in the treatment of CF infections...
- Evaluation and strategy for use of MIRU-VNTRplus, a multifunctional database for online analysis of genotyping data and phylogenetic identification of Mycobacterium tuberculosis complex isolatesCaroline Allix-Béguec
Genoscreen, 1, rue du Professeur Calmette, Lille 59019 Cedex, France
J Clin Microbiol 46:2692-9. 2008..The MIRU-VNTRplus database is a powerful tool for high-resolution clonal identification and has little equivalent in terms of functionalities among the bacterial genotyping databases available so far...
- SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosisKapil Tahlan
Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute for Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA
Antimicrob Agents Chemother 56:1797-809. 2012..Our results suggest that MmpL3 is the target of SQ109 and that MmpL3 is a transporter of mycobacterial TMM...
- Synergy, antagonism, and what the chequerboard puts between themF C Odds
J Antimicrob Chemother 52:1. 2003
- A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteriaJ N Eloff
Department of Pharmacology, University of Pretoria, South Africa
Planta Med 64:711-3. 1998..MIC values determined for sulfisoxazole, norfloxacin, gentamicin, and nitrofuratoin were similar to values indicated in the literature but values obtained with trimethroprim and ampicillin were higher with some bacteria...
- Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobialsA L Spoering
Department of Biology, Northeastern University, 405 Mugar, 360 Huntington Ave, Boston, MS 02115, USA
J Bacteriol 183:6746-51. 2001..We further suggest that tolerance to antibiotics in stationary-phase or biofilm cultures is largely dependent on the presence of persister cells...
- Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosisPatricia J Campbell
Mycobacteriology Laboratory Branch, Division of Tuberculosis Elimination, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Bldg 17, Room 4029, M S F08, Atlanta, GA 30333, USA
Antimicrob Agents Chemother 55:2032-41. 2011..tuberculosis complex. Further, the results can be used to design diagnostic tests utilizing other mutation detection technologies...
- Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in iranAli Akbar Velayati
Mycobacteriology Research Centre, the National Research Institute of Tuberculosis and Lung Disease, World Health Organization Collaborating Centre, Shahid Beheshti University, Darabad, Tehran, Iran
Chest 136:420-5. 2009..The study documented the emergence of new forms of resistant bacilli (totally drug-resistant [TDR] or super extensively drug-resistant [XDR] tuberculosis [TB] strains) among patients with multidrug-resistant TB (MDR-TB)...
- A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosisC K Stover
PathoGenesis Corporation, Seattle, Washington 98119, USA
Nature 405:962-6. 2000..tuberculosis and promising oral activity in animal infection models. We conclude that nitroimidazopyrans offer the practical qualities of a small molecule with the potential for the treatment of tuberculosis...
- Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolatesLaure Diancourt
Unité Biodiversité des Bactéries Pathogènes Emergentes U389 INSERM, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
J Clin Microbiol 43:4178-82. 2005..Forty distinct allelic profiles were identified. MLST data were validated against ribotyping and showed high (96%) discriminatory power. The MLST approach provides unambiguous data useful for the epidemiology of K. pneumoniae isolates...
- Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosisLawrence R Mulcahy
Department of Biology and Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts 02115, USA
J Bacteriol 192:6191-9. 2010..Persisters may play a similarly critical role in the recalcitrance of other chronic infections...
- Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membraneAnna E Grzegorzewicz
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA
Nat Chem Biol 8:334-41. 2012....
- Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzymeChi Hye Park
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
Antimicrob Agents Chemother 50:3953-5. 2006..aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes...
- The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilmsH Ceri
Biofilm Research Group, University of Calgary, Calgary, Alberta, Canada T2N 1N4
J Clin Microbiol 37:1771-6. 1999..The CBD offers a new technology for the rational selection of antibiotics effective against microbial biofilms and for the screening of new effective antibiotic compounds...
- Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004)Gary J Moet
JMI Laboratories, North Liberty, IA 52317, USA
Diagn Microbiol Infect Dis 57:7-13. 2007..48.0%) when compared with other regions. Continued surveillance of pathogen prevalence and antimicrobial resistance patterns should provide information that is important to improve empiric care particularly in the hospital environment...
- Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious diseaseLeah E Cowen
Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
Proc Natl Acad Sci U S A 106:2818-23. 2009....
- Epidemiology of antituberculosis drug resistance 2002-07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance SurveillanceAbigail Wright
Stop TB Department, WHO, Geneva, Switzerland
Lancet 373:1861-73. 2009..The Global Project on Anti-Tuberculosis Drug Resistance has been gathering data since 1994. This study provides the latest data on the extent of drug resistance worldwide...
- High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failureMagnus Unemo
WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
Antimicrob Agents Chemother 56:1273-80. 2012..Nevertheless, new treatment strategies and/or drugs and, ideally, a vaccine are essential to develop for efficacious gonorrhea management...
- Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxoneMakoto Ohnishi
National Institute of Infectious Diseases, Tokyo, Japan
Antimicrob Agents Chemother 55:3538-45. 2011..Ultimately, the development of new drugs for efficacious gonorrhea treatment is necessary...
- Nasal colonization of humans with methicillin-resistant Staphylococcus aureus (MRSA) CC398 with and without exposure to pigsChristiane Cuny
Robert Koch Institute, Wernigerode Branc, Wernigerode, Germany
PLoS ONE 4:e6800. 2009..The study presented here addresses the question of further transmission to non exposed humans...
- Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implicationsBenjamin P Howden
Department of Infectious Diseases, Austin Health, Victoria, Australia
Clin Microbiol Rev 23:99-139. 2010..Given the subtleties of vancomycin susceptibility testing against S. aureus, it is imperative that diagnostic laboratories use well-standardized methods and have a framework for detecting reduced vancomycin susceptibility in S. aureus...
- ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in ChinaYan Qi
Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
J Antimicrob Chemother 66:307-12. 2011..Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae has spread rapidly in China. In this study, we aimed to investigate the molecular epidemiology of KPC-producing K. pneumoniae isolates in China...
- Evaluation of the analytical performance of the Xpert MTB/RIF assayRobert Blakemore
Division of Infectious Disease, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
J Clin Microbiol 48:2495-501. 2010..M. tuberculosis was not detected until at least 10(8) copies of an MTBDRplus amplicon were spiked into 1 ml of sputum, suggesting that false-positive results would be unlikely to occur...
- Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?Kyle J Popovich
Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
Clin Infect Dis 46:787-94. 2008..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
- Methicillin-resistant S. aureus infections among patients in the emergency departmentGregory J Moran
Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
N Engl J Med 355:666-74. 2006..Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA...
- Detection of new methicillin-resistant Staphylococcus aureus strains that carry a novel genetic homologue and important virulence determinantsArtur J Sabat
Department of Medical Microbiology, University of Groningen, Groningen, The Netherlands
J Clin Microbiol 50:3374-7. 2012..The worrisome emergence of such toxigenic MRSA strains raises concerns that MRSA strains with enhanced virulence potential and impaired detectability by standard molecular assays may spread in Europe...
- Livestock-associated methicillin-resistant Staphylococcus aureus in humans, EuropeBrigitte A G L van Cleef
Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Emerg Infect Dis 17:502-5. 2011..Livestock-associated MRSA ST398 accounted for only a small proportion of MRSA isolates from humans; most were from the Netherlands, Belgium, Denmark, and Austria...
- Performance assessment of the GenoType MTBDRsl test and DNA sequencing for detection of second-line and ethambutol drug resistance among patients infected with multidrug-resistant Mycobacterium tuberculosisWei Lun Huang
Reference Laboratory of Mycobacteriology, Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, Republic of China
J Clin Microbiol 49:2502-8. 2011..We recommend including new alleles consisting of the eis promoter and embB genes in molecular analysis. However, conventional DST is necessary to rule out false-negative results from molecular assays...
- Genetic features of blaNDM-1-positive EnterobacteriaceaeLaurent Poirel
Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
Antimicrob Agents Chemother 55:5403-7. 2011..The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes...
- rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. novToidi Adekambi
Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, 27, Boulevard Jean Moulin, Université de la Méditerranée and Assistance Publique Hôpitaux de Marseille Timone, Fédération de Microbiologie Clinique, Marseille, France
Int J Syst Evol Microbiol 56:133-43. 2006....
- Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, barcelona, Spain, from 2002 to 2003Benito Almirante
Infectious Diseases Division, Hospital Universitari Vall d Hebron, Avda Vall d Hebron, 119 129, 08035 Barcelona, Spain
J Clin Microbiol 43:1829-35. 2005..Antifungal medication and catheter removal are critical in preventing mortality...
- Sampling the antibiotic resistomeVanessa M D'Costa
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada, L8N 3Z5
Science 311:374-7. 2006..They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms...
- Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter sppNeil Woodford
Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Ave, London NW9 5HT, UK
Int J Antimicrob Agents 27:351-3. 2006..Genes encoding OXA-58 were detected (with bla(OXA-51-like)) in a cluster of related isolates from a single hospital. This simple assay will assist in monitoring the mechanisms responsible for carbapenem resistance in Acinetobacter spp...
- Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniaeH Yigit
Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Antimicrob Agents Chemother 45:1151-61. 2001..pneumoniae strain 1534 is mainly due to production of a novel Bush group 2f, class A, carbapenem-hydrolyzing beta-lactamase, KPC-1, although alterations in porin expression may also play a role...
- Microscopic-observation drug-susceptibility assay for the diagnosis of TBDavid A J Moore
Department of Infectious Diseases and Immunity and the Wellcome Centre for Clinical Tropical Medicine, Imperial College London, Faculty of Medicine Hammersmith Campus, London, United Kingdom
N Engl J Med 355:1539-50. 2006....
- Prevalence of livestock-associated MRSA in communities with high pig-densities in The NetherlandsBrigitte A van Cleef
Centre for Infectious Disease Control Netherlands, RIVM National Institute for Public Health and the Environment, Bilthoven, The Netherlands
PLoS ONE 5:e9385. 2010..This cross-sectional study aimed to determine the spread to persons not in direct contact with livestock in areas with a high density of pig farms...
- Agr-mediated dispersal of Staphylococcus aureus biofilmsBlaise R Boles
Department of Microbiology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
PLoS Pathog 4:e1000052. 2008..These findings indicate that induction of the agr system in established S. aureus biofilms detaches cells and demonstrate that the dispersal mechanism requires extracellular protease activity...
- Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergenceFrancois Vandenesch
INSERM E0230, Lyon, France
Emerg Infect Dis 9:978-84. 2003..Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA...
- Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibioticJ Harder
Clinical Research Unit, Department of Dermatology, University Hospital Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
J Biol Chem 276:5707-13. 2001..hBD-3 therefore might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis...
- Complete genome sequence of the multiresistant taxonomic outlier Pseudomonas aeruginosa PA7Paul H Roy
Departement de Biochimie et de Microbiologie, and Centre de recherche en infectiologie, Universite Laval, Quebec, Quebec, Canada
PLoS ONE 5:e8842. 2010..PA7 is serotype O12 and pyoverdin type II. Preliminary proteomic studies indicate numerous differences with PAO1, some of which are probably a consequence of a frameshift mutation in the mvfR quorum sensing regulatory gene...
- Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in EuropeJonathan A Otter
Department of Infection, King s College London and St Thomas Hospital, London, UK
Lancet Infect Dis 10:227-39. 2010..An understanding of the epidemiology of community-associated MRSA is essential to guide new control initiatives to prevent these organisms from becoming endemic in Europe...
- The diarylquinoline TMC207 for multidrug-resistant tuberculosisAndreas H Diacon
Centre for Clinical Tuberculosis Research, the Department of Science and Technology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, all in South Africa
N Engl J Med 360:2397-405. 2009..TMC207 potently inhibits drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro and shows bactericidal activity in patients who have drug-susceptible pulmonary tuberculosis...
- Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activityAles Panacek
Department of Physical Chemistry, Palacky University, Svobody 26, 771 46 Olomouc, Czech Republic
J Phys Chem B 110:16248-53. 2006..Antibacterial activity of silver nanoparticles was found to be dependent on the size of silver particles. A very low concentration of silver (as low as 1.69 mug/mL Ag) gave antibacterial performance...
- Bacteroides: the good, the bad, and the nitty-grittyHannah M Wexler
Wadsworth Anaerobe Laboratory, Greater Los Angeles VA Healthcare Systems University of California, Los Angeles, CA 90073, USA
Clin Microbiol Rev 20:593-621. 2007..Clinically, Bacteroides species have exhibited increasing resistance to many antibiotics, including cefoxitin, clindamycin, metronidazole, carbapenems, and fluoroquinolones (e.g., gatifloxacin, levofloxacin, and moxifloxacin)...
- Prevalence and characterisation of CTX-M β-lactamases amongst Escherichia coli isolates from healthy food animals in ChinaHongqing Zheng
College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues, South China Agricultural University, Guangzhou 510642, China
Int J Antimicrob Agents 39:305-10. 2012..This study demonstrates that commensal E. coli from healthy food animals can be important reservoirs of bla(CTX-M) genes and may contribute to the dissemination and transfer of these β-lactamase genes throughout China...
- Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumoniaKai Hu Yao
Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing, China
Vaccine 29:2296-301. 2011..The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A...
- Population structure of Staphylococcus aureus from remote African Babongo PygmiesFrieder Schaumburg
Institute of Medical Microbiology, University of Munster, Munster, Germany
PLoS Negl Trop Dis 5:e1150. 2011..The objective of our study was to investigate the S. aureus carriage among a remote indigenous African population and to determine the molecular characteristics of the isolates, particularly those that were PVL-positive...
- Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UKMichel Doumith
Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London NW95EQ, UK
J Antimicrob Chemother 63:659-67. 2009..n = 28) and Enterobacter spp. (n = 27) referred from multiple hospitals to the UK national reference laboratory...
- Class 1 integrons and tetracycline resistance genes in alcaligenes, arthrobacter, and Pseudomonas spp. isolated from pigsties and manured soilYvonne Agersø
Danish Food and Veterinary Research, Section of Antimicrobial Resistance, Bulowsvej 27, 1790 Copenhagen V, Denmark
Appl Environ Microbiol 71:7941-7. 2005..Use of tetracyclines in food animal production may increase not only Tc(r) but also multidrug resistance (caused by the presence tet genes and in-1) in bacteria...
- Emergence of NDM-1 metallo-β-lactamase in Pseudomonas aeruginosa clinical isolates from SerbiaBranko Jovcic
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
Antimicrob Agents Chemother 55:3929-31. 2011..Five additional isolates from different patients clonally related to either MMA83 or MMA533 were found to be NDM-1 positive...
- GenoType MTBDR assays for the diagnosis of multidrug-resistant tuberculosis: a meta-analysisD I Ling
Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, QC H3A 1A2, Canada
Eur Respir J 32:1165-74. 2008..While specificity is excellent for isoniazid, sensitivity estimates were modest and variable. Together with data from demonstration projects, the meta-analysis provides evidence for policy making and clinical practice...
- Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'Catarina Milheiriço
Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
J Antimicrob Chemother 60:42-8. 2007..To develop and validate a new multiplex PCR strategy for subtyping SCCmec type IV methicillin-resistant Staphylococcus aureus (MRSA) strains-SCCmec IV multiplex PCR...
- Antimicrobial resistance: Not community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)! A clinician's guide to community MRSA - its evolving antimicrobial resistance and implications for therapyKyra Chua
Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Clin Infect Dis 52:99-114. 2011..Continued monitoring of global epidemiology and emerging drug resistance data is critical for the effective management of these infections...
- An outbreak of infection due to beta-Lactamase Klebsiella pneumoniae Carbapenemase 2-producing K. pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomesMaria Souli
4th Dept of Internal Medicine, University General Hospital Attikon, 1 Rimini Str 124 62, Chaidari, Greece
Clin Infect Dis 50:364-73. 2010..We describe the emergence and spread of Klebsiella pneumoniae carbapenemase 2 (KPC-2)-producing K. pneumoniae at a Greek University hospital...
- Commensal Escherichia coli of healthy humans: a reservoir for antibiotic-resistance determinantsJannine K Bailey
School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia
J Med Microbiol 59:1331-9. 2010..coli of healthy humans represent an important reservoir for numerous antibiotic-resistance genes in many combinations. However, measuring the true extent of resistance carriage in commensal E. coli requires in-depth analysis...
- Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United StatesJames A Karlowsky
Focus Technologies, Inc, 13665 Dulles Technology Drive, Suite 200, Herndon, VA 20171 4603, USA
Antimicrob Agents Chemother 46:2540-5. 2002..8 to 17.0%) from 1995 to 2001 but demonstrated considerable regional and institutional variation in 2001. Therapies other than SXT may need to be considered in some locations...
- Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?David M Livermore
Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London, United Kingdom
Clin Infect Dis 34:634-40. 2002..A few isolates of P. aeruginosa are resistant to all reliable antibiotics, and this problem seems likely to grow with the emergence of integrins that carry gene cassettes encoding both carbapenemases and amikacin acetyltransferases...
- Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patternsKhetam Hussein
Infectious Diseases Unit, Rambam Medical Center, Haifa, Israel
Infect Control Hosp Epidemiol 30:666-71. 2009..Carbapenem resistance among isolates of Klebsiella pneumoniae has been unusual...
- Resistance among Streptococcus pneumoniae: Implications for drug selectionPeter C Appelbaum
Departments of Pathology and Clinical Microbiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA
Clin Infect Dis 34:1613-20. 2002..Efforts should be made to prevent pneumococcal infections in high-risk patients through vaccination...
- Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae)V Kuete
Department of Biochemistry, Faculty of Science, University of Dschang, P O BOX 67, Dschang, Cameroon
J Ethnopharmacol 120:17-24. 2008..FCB was found to be more active than FCR on most of the tested organisms. The results provided evidence that the studied plants extract, as well as some of the isolated compounds might be potential sources of new antimicrobial drug...
- Anti-staphylococcal plant natural productsSimon Gibbons
Centre for Pharmacognosy and Phytotherapy, University of London School of Pharmacy, 29 39 Brunswick Square, London, UKWC1N 1AX
Nat Prod Rep 21:263-77. 2004
- Continued impact of pneumococcal conjugate vaccine on carriage in young childrenSusan S Huang
Division of Infectious Diseases, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
Pediatrics 124:e1-11. 2009....
- AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutantsH Okusu
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
J Bacteriol 178:306-8. 1996..This experiment identified the AcrAB system as the major pump responsible for making the Mar mutants resistant to many agents, including tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin...
- Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilmsPriya Uppuluri
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Antimicrob Agents Chemother 52:1127-32. 2008..These findings reveal that calcineurin contributes to fluconazole resistance of biofilms and provide evidence that synergistic drug combinations may prove efficacious as novel therapeutic interventions to treat or prevent biofilms...
- Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005Matthew R Moore
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
J Infect Dis 197:1016-27. 2008..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
- Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapyO Lomovskaya
Microcide Pharmaceuticals, Inc, Mountain View, California 94043, USA
Antimicrob Agents Chemother 45:105-16. 2001..aeruginosa strains that are highly resistant to fluoroquinolones...
- Antibacterial properties of Ag nanoparticle loaded multilayers and formation of magnetically directed antibacterial microparticlesDaeyeon Lee
Department of Chemical Engineering and the Center for Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Langmuir 21:9651-9. 2005..The minimum inhibitory concentration (MIC) of nanocomposite coated microspheres was determined by the agar dilution technique: antibacterial magnetic microspheres with higher concentrations of Ag nanoparticles exhibited lower MIC values...
- Fluoroquinolones, tuberculosis, and resistanceAmy Sarah Ginsburg
Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Lancet Infect Dis 3:432-42. 2003..Discussion and education regarding appropriate use are necessary to preserve the effectiveness of this antibiotic class against the hazard of growing resistance...
- Carbapenemases: the versatile beta-lactamasesAnne Marie Queenan
Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
Clin Microbiol Rev 20:440-58, table of contents. 2007..This review updates the characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria...
- Identification and characterization of novel reptile cathelicidins from elapid snakesHui Zhao
Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan 650223, China
Peptides 29:1685-91. 2008..Snake cathelicidins also showed a close relationship with avian fowlicidins (1-3) and chicken myeloid antimicrobial peptide 27. Elapid cathelicidins might be used as models for the development of novel therapeutic drugs...
- Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycinGeorge Sakoulas
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
Antimicrob Agents Chemother 46:1492-502. 2002..These findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through the development of vancomycin tolerance...
- Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycinK Hiramatsu
Department of Bacteriology, Juntendo University, Tokyo, Japan
Lancet 350:1670-3. 1997..Two important questions need to be answered: (1) what is the prevalence of VRSA, and (2) by what mechanism does vancomycin resistance occur...
- Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar TyphimuriumKunihiko Nishino
Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
Mol Microbiol 59:126-41. 2006..The PhoP/PhoQ two-component system is a major regulator of Salmonella virulence, which underscores the connection between drug efflux systems and virulence...
- New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolateKunikazu Yamane
Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
Antimicrob Agents Chemother 51:3354-60. 2007..coli was first identified. Surveillance of the qepA-harboring clinical isolates should be encouraged to minimize further dissemination of the kind of plasmid-dependent FQ resistance determinants among pathogenic microbes...
- Identification and characterization of methicillin-resistant coagulase-negative staphylococci from bovine mastitisAndrea T Fessler
Institute of Farm Animal Genetics, Friedrich Loeffler Institut FLI, Neustadt Mariensee, Germany
J Antimicrob Chemother 65:1576-82. 2010....
- Nitogen reduction and xenobiotic responseLauren A Trepanier; Fiscal Year: 2010..The ultimate goal of these studies is to find better ways to prevent these adverse reactions. ..
- Novel antibacterial agents for treatment of TularemiaNachum Kaplan; Fiscal Year: 2004..tularensis microbiological data and animal model data to warrant inclusion of the information on the product label as a narrow spectrum agent that could be used in the event of a F. tularensis release. ..
- Host Cell Killing by EPEC: Central Role in PathogenesisJOHN CRANE; Fiscal Year: 2005..coli (RDEC-1) and rabbit EPEC (REPEC). ..
- Validation of topography-biased antibody librariesSylvia Smith; Fiscal Year: 2005..Furthermore, this study will lay the foundation for further development of highly specific and high affinity antibodies to a diverse array of toxins. ..
- C. Perfringens to Induce Anti-HIV Mucosal ImmunityPhalguni Gupta; Fiscal Year: 2006..The proposed study provides a novel strategy to induce strong mucosal immunity against HIV-1 which can lead to development of an anti-HlV-1 oral vaccine due to its safety, low production cost and easy administration. ..
- Novel Inorganic NucleasesJames Cowan; Fiscal Year: 2006..abstract_text> ..
- Therapeutic vaccine against tuberculosisLee Riley; Fiscal Year: 2006..Therapeutic vaccines against TB is a major priority in TB control, and we have an opportunity to identify such products by a novel approach using a simple, inexpensive, and reproducible animal model. ..
- Effect of Zinc in Enteropathogenic E. coli InfectionJOHN CRANE; Fiscal Year: 2006..abstract_text> ..
- Plasmid-Mediated Quinolone ResistanceGeorge Jacoby; Fiscal Year: 2007..unreadable] [unreadable]..
- Neonatal Immunization with Acellular Pertussis VaccinesNatasha Halasa; Fiscal Year: 2007....
- Orgin of multidrug resistant uropathogenic E. coliLee Riley; Fiscal Year: 2008..This knowledge should lead to the implementation of improved control of drug-resistant infectious diseases. ..
- CV-N Secreting Lactobacilli and Retrocyclin MicrobicidesPhalguni Gupta; Fiscal Year: 2008..The development of a combination microbicide product that incorporates CV-N/LAB and retrocyclin would provide a novel strategy which is expected to have potent anti-HIV activity without inducing cellular toxicity. ..
- SEMEN IN TRANSMISSION OF HIVPhalguni Gupta; Fiscal Year: 2010..The information from the proposed study will be extremely useful to our understanding of transmission and eradication of HIV-1 following therapy. ..
- Novel Engineered Synthetic Metallodrugs Directed Against HCVSan Ching; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- In vivo regulation of M. tuberculosis cell wall lipidsLee W Riley; Fiscal Year: 2010..tuberculosis and granulomas may contribute to our understanding of the mechanism of persistence of M. tuberculosis that could lead to new tests to differentiate active TB from latent TB infection. ..
- Enteropathogenic and Toxigenic E.coli InteractionsJOHN CRANE; Fiscal Year: 2004..abstract_text> ..
- ORGAN CULTURE TO STUDY HIV TRANSMISSIONPhalguni Gupta; Fiscal Year: 2003....
- ASSESSMENT OF CD8 SUPPRESSION OF HIV/SIV TO VACCINESPhalguni Gupta; Fiscal Year: 2002..The information generated from this project will be extremely useful in determining the utility of the suppressive activity in evaluating efficacy of a vaccine. ..
- MOLECULAR BIOLOGY OF INFECTION WITH M TUBERCULOSISLee Riley; Fiscal Year: 2002..In addition, these studies may identify several potential targets for new chemotherapeutic agents or vaccine candidates. ..
- ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSISLee Riley; Fiscal Year: 2001....
- Epidemiology of an uropathogenic E coli clonal groupLee Riley; Fiscal Year: 2003..coli can be spread by contaminated ingestible vehicles, and use the data generated from this project to design long-term studies to better characterize risk factors associated with CgA infection. ..
- HIV IN SEMEN FROM INFECTED SUBJECTS FROM INDIAPhalguni Gupta; Fiscal Year: 2006..Semen and blood plasma and mononuclear cells samples collected through our collaborative study in India will be used in this project. [unreadable] [unreadable]..
- BCG + hsp, a New Tuberculosis VaccineBoris Nikonenko; Fiscal Year: 2003..We will also examine the antibiotic sensitivity of this rBCGdeltahspR to 10 commonly used TB drugs to ensure that the genetic manipulations performed have not made it less sensitive to drug treatment. ..
- Cytology and function of ParA in E. coliJOSEPH A POGLIANO; Fiscal Year: 2010..The findings from this analysis of a representative ParAB plasmid partitioning system should have wide implications for our understanding of plasmid and chromosome segregation. ..
- C. difficile Toxin Membrane Test with Magnetic ParticlesROBERT CARMAN; Fiscal Year: 2004..perfringens enterotoxin, another cause of AAD. The technology developed in this project will be widely applicable for the development of new highly sensitive stool antigen tests. ..
- SALIVARY PROTEINS IN DENTAL INTEGUMENTSFRANK OPPENHEIM; Fiscal Year: 2009..abstract_text> ..
- Molecular Target Focused Discovery of Anticancer DrugsGeorge R Pettit; Fiscal Year: 2010....
- Evolution of Stress-Induced Bacterial ToxinsMargaret A Riley; Fiscal Year: 2010....
- Office for Access to Biomedical Research and TrainingCHARLES BIGGER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- MOLECULAR EVOLUTION OF ENTERIC BACTERIOCINSMargaret Riley; Fiscal Year: 2002..we gain regarding the natural role of bacteriocins, and the defenses raised against them within bacterial communities, can be directly applied to the rational application of novels antimicrobials to human health issues ..
- ORIGIN AND DYNAMICS OF HIV-1 IN SEMENPhalguni Gupta; Fiscal Year: 2002..The information from the proposed study will be extremely useful in the understanding of transmission and eradication of HIV following therapy. ..
- Developing Murine Models of HCV ReplicationSUSAN UPRICHARD; Fiscal Year: 2004..abstract_text> ..
- Polymyxin-resistant Pseudomonas in CF Lung InfectionSamuel M Moskowitz; Fiscal Year: 2010..An interdisciplinary study of polymyxin resistant Pseudomonas from patients with cystic fibrosis is proposed to pinpoint the bacterial genes responsible for this resistance, so that management strategies may be devised to overcome it. ..
- Clinical Impact of Quinolone-Resistant E.coli carriageEbbing Lautenbach; Fiscal Year: 2007..unreadable] [unreadable]..
- Cryptococcus gatti mating 1oci; mapping and gene studyVishnu Chaturvedi; Fiscal Year: 2004..abstract_text> ..
- DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUESJEANNE JORDAN; Fiscal Year: 2003....
- Rural Trial of Clinic Order Entry with Decision SupportMatthew Samore; Fiscal Year: 2006..The cost impact of the intervention will be measured to allow a comprehensive assessment of the value of this HIT. [unreadable] [unreadable]..
- BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSEThomas Russo; Fiscal Year: 2004..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
- CANDIDA PATHOGENESIS IN SURGERY AND TRAUMACarol Wells; Fiscal Year: 2007..Such knowledge should accelerate our ability to diagnose, treat, and control systemic candidiasis. ..
- Biofilm growth and detachment of an oral pathogenJeffrey Kaplan; Fiscal Year: 2007..abstract_text> ..
- Bacterial DnaA Initiator Protein: A Target for Novel AntibioticsMichelle Butler; Fiscal Year: 2008..This proposal describes a new type of screening assay that can identify inhibitors of DnaA, a previously unexploited protein involved in the initiation of DNA synthesis. [unreadable] [unreadable] [unreadable]..
- A NOVEL THERAPY FOR RESPIRATORY SYNCYTIAL VIRUSMichelle Butler; Fiscal Year: 2003..The goal is to file an IND within three years of initiation of the Phase I SBIR studies. ..
- DEVELOPMENT OF SCREENS FOR BACILLUS ANTHRACIS TARGETSMichelle Butler; Fiscal Year: 2005..In Phase II, we will optimize the most promising compounds to develop novel leads and candidate drugs for pre-clinical testing in animal models of infection. ..
- DEVELOPMENT OF INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS DNA REPLICATIONMichelle Butler; Fiscal Year: 2007..In Phase II, we will optimize the most promising compounds to develop novel leads and candidate drugs for pre-clinical testing in animal models of infection. [unreadable] [unreadable] [unreadable]..
- BACTERIAL DNA POLYMERASES: TARGET FOR NOVEL ANTIBIOTICSMichelle Butler; Fiscal Year: 2005..The SAR development and in vitro and in vivo characterization studies are the subject of this Phase II application. ..
- MODELS FOR TESTING CANDIDATE TOPICAL MICROBICIDES FOR CYTOTOXICITY AND ACTIVITY AMary Lampe; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Molecular Target Focused Discovery of Anticancer DrugsGEORGE PETTIT; Fiscal Year: 2007..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
- HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICEStephen Barthold; Fiscal Year: 2004..abstract_text> ..
- Mechanisms of Tandem Repeat Deletion in Group B StrepKAREN PUOPOLO; Fiscal Year: 2006..The training goal of this project is to prepare the applicant for a career in bacterial genetic research by providing didactic education and the opportunity to develop laboratory expertise in this rapidly evolving field. ..
- IgA inducing peptideD Estes; Fiscal Year: 2005..In addition, the proposed studies will begin to examine determine the potential relationship between IGIP and clinical abnormality in IgA production. ..
- 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETINGStephen Barthold; Fiscal Year: 2003....
- 5th Comparative Medicine Resource Center Director Mtg.Stephen Barthold; Fiscal Year: 2008....