radiation hybrid mapping

Summary

Summary: A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.

Top Publications

  1. ncbi A physical map of the 1-gigabase bread wheat chromosome 3B
    Etienne Paux
    Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
    Science 322:101-4. 2008
  2. ncbi CARHTA GENE: multipopulation integrated genetic and radiation hybrid mapping
    Simon de Givry
    INRA, Biométrie et Intelligence Artificielle Génétique Cellulaire, BP 27, 31326 Castanet Tolosan Cedex, France
    Bioinformatics 21:1703-4. 2005
  3. pmc A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes
    Andy Lin
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genome Res 20:1122-32. 2010
  4. ncbi Constructing plant radiation hybrid panels
    Julie Wardrop
    Scottish Crop Research Institute, Invergowrie, Dundee, DD2 5DA, Scotland, UK
    Plant J 31:223-8. 2002
  5. pmc Integrative mapping analysis of chicken microchromosome 16 organization
    Romain Solinhac
    UMR INRA ENVT Laboratoire de Génétique Cellulaire, INRA, Castanet Tolosan, 31326, France
    BMC Genomics 11:616. 2010
  6. pmc High-resolution radiation hybrid map of wheat chromosome 1D
    Venu Kalavacharla
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19141, USA
    Genetics 173:1089-99. 2006
  7. pmc Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxity in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris)
    Kevin Chase
    Department of Biology, University of Utah, Salt Lake City, Utah 84102, USA
    Am J Med Genet A 124:239-47. 2004
  8. ncbi Radiation hybrid mapping of 304 novel microsatellites in the domestic cat genome
    M Menotti-Raymond
    Laboratory of Genomic Diversity, National Cancer Institute, Department of Health and Human Services, Frederick, MD 21702, USA
    Cytogenet Genome Res 102:272-6. 2003
  9. ncbi Independent expansion of the keratin gene family in teleostean fish and mammals: an insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish
    Bhaja Krushna Padhi
    Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, ON, Canada K1Y 4E9
    Gene 368:37-45. 2006
  10. ncbi A radiation hybrid map of the European sea bass (Dicentrarchus labrax) based on 1581 markers: Synteny analysis with model fish genomes
    Richard Guyon
    CNRS UMR 6061 Institut de Génétique et Développement, Universite de Rennes 1, 2 Avenue du Pr Leon Bernard, F 35043 Rennes Cedex, France
    Genomics 96:228-38. 2010

Research Grants

  1. MAPPING AND SEQUENCING THE HUMAN GENOME
    Richard Myers; Fiscal Year: 1999
  2. MOLECULAR GENETICS OF BIPOLAR AFFECTIVE DISORDER
    Charles Richard; Fiscal Year: 1993
  3. INTEGRATED ZEBRAFISH GENOMIC RESOURCES
    Stephen Johnson; Fiscal Year: 2003
  4. ANALYSIS OF KILLER CELL INHIBITORY RECEPTOR COMPLEX
    David Lawlor; Fiscal Year: 1999
  5. COMPARATIVE HYBRIDIZATION OF AP PCR ARRAYS
    SERGEI MALKHOSYAN; Fiscal Year: 2000
  6. COMPARATIVE HYBRIDIZATION OF AP PCR ARRAYS
    SERGEI MALKHOSYAN; Fiscal Year: 2003
  7. NF2 BINDING PROTEINS
    Stefan Pulst; Fiscal Year: 2000
  8. MOLECULAR GENETICS OF PAR-3
    Lisa Cupit; Fiscal Year: 2004
  9. IDENTIFICATION AND EXPRESSION OF SKIN SPECIFIC GENES
    Peter Byers; Fiscal Year: 2002
  10. HIGH EFFICIENCY MAPPING WITH A HUMAN MICROCELL PANEL
    Ann Killary; Fiscal Year: 1992

Detail Information

Publications210 found, 100 shown here

  1. ncbi A physical map of the 1-gigabase bread wheat chromosome 3B
    Etienne Paux
    Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
    Science 322:101-4. 2008
    ..This physical map establishes a template for the remaining wheat chromosomes and demonstrates the feasibility of constructing physical maps in large, complex, polyploid genomes with a chromosome-based approach...
  2. ncbi CARHTA GENE: multipopulation integrated genetic and radiation hybrid mapping
    Simon de Givry
    INRA, Biométrie et Intelligence Artificielle Génétique Cellulaire, BP 27, 31326 Castanet Tolosan Cedex, France
    Bioinformatics 21:1703-4. 2005
    ..Dedicated heuristics for framework mapping are also included. CAR(H)(T)A GENE: can be used as a C++ library, through a shell command and a graphical interface. The XML output for companion tools is integrated...
  3. pmc A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes
    Andy Lin
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genome Res 20:1122-32. 2010
    ..The radiation hybrid (RH) network constitutes a platform for understanding the systems biology of the mammalian cell...
  4. ncbi Constructing plant radiation hybrid panels
    Julie Wardrop
    Scottish Crop Research Institute, Invergowrie, Dundee, DD2 5DA, Scotland, UK
    Plant J 31:223-8. 2002
    ..RH panels of the type generated can be used for physical mapping, map-based cloning, or sequence contig assembly. RH resources will greatly aid the physical characterisation of crop plants with large genomes...
  5. pmc Integrative mapping analysis of chicken microchromosome 16 organization
    Romain Solinhac
    UMR INRA ENVT Laboratoire de Génétique Cellulaire, INRA, Castanet Tolosan, 31326, France
    BMC Genomics 11:616. 2010
    ..The purpose of the present study is to construct and present high resolution integrated maps of GGA16 to refine its organization and improve its coverage with genetic markers...
  6. pmc High-resolution radiation hybrid map of wheat chromosome 1D
    Venu Kalavacharla
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19141, USA
    Genetics 173:1089-99. 2006
    ..To date, this is the highest resolution that has been obtained by plant RH mapping and serves as a first step for the development of RH resources in wheat...
  7. pmc Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxity in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris)
    Kevin Chase
    Department of Biology, University of Utah, Salt Lake City, Utah 84102, USA
    Am J Med Genet A 124:239-47. 2004
    ..The other, associated with FH2598, was significant for the right but not the left hip. For both QTLs, some extreme phenotypes were best explained by specific interactions between haplotypes...
  8. ncbi Radiation hybrid mapping of 304 novel microsatellites in the domestic cat genome
    M Menotti-Raymond
    Laboratory of Genomic Diversity, National Cancer Institute, Department of Health and Human Services, Frederick, MD 21702, USA
    Cytogenet Genome Res 102:272-6. 2003
    ..These resources can also be extended to the remaining 36 species of the cat family for population genetic and evolutionary genomic analyses...
  9. ncbi Independent expansion of the keratin gene family in teleostean fish and mammals: an insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish
    Bhaja Krushna Padhi
    Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, ON, Canada K1Y 4E9
    Gene 368:37-45. 2006
    ..By comparative sequence analysis and radiation hybrid mapping, we identified 16 type I and 7 type II keratin genes in the zebrafish genome...
  10. ncbi A radiation hybrid map of the European sea bass (Dicentrarchus labrax) based on 1581 markers: Synteny analysis with model fish genomes
    Richard Guyon
    CNRS UMR 6061 Institut de Génétique et Développement, Universite de Rennes 1, 2 Avenue du Pr Leon Bernard, F 35043 Rennes Cedex, France
    Genomics 96:228-38. 2010
    ..The RH map further positions sea bass as a genetic and evolutionary model of Perciformes and supports their ongoing aquaculture expansion...
  11. ncbi A high-resolution radiation hybrid map of the human genome draft sequence
    M Olivier
    Stanford Human Genome Center, Stanford University School of Medicine, 975 California Avenue, Palo Alto, CA 94304, USA
    Science 291:1298-302. 2001
    ..The TNG map order was identical to one of the two sequence orders in 60% of these discrepant cases...
  12. ncbi Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12
    R Li
    Room P 114, Stanford Center for Narcolepsy Research, 1201 Welch Road, Stanford, California 94305 5485, USA
    Genomics 73:299-315. 2001
    ..These data further establish the dog as a system for studying disease genes of interest to human populations and highlight feasible approaches for positional cloning of disease genes in organisms where genomic resources are limited...
  13. pmc Construction of a radiation hybrid map of chicken chromosome 2 and alignment to the chicken draft sequence
    Sophie Leroux
    Laboratoire de Genetique Cellulaire, INRA, Castanet Tolosan, 31326, France
    BMC Genomics 6:12. 2005
    ..Finally, all markers from the RH map were localised on the chicken draft sequence assembly to check for eventual discordances...
  14. pmc Radiation hybrid mapping of cataract genes in the dog
    Linda S Hunter
    J A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Mol Vis 12:588-96. 2006
    ..These can be used for segregation testing of the candidate genes in canine cataract pedigrees...
  15. pmc A gene-based radiation hybrid map of chicken microchromosome 14: comparison to human and alignment to the assembled chicken sequence
    Mireille Morisson
    Laboratoire de Genetique Cellulaire, Institut National de la Recherche Agronomique, Castanet Tolosan, France
    Genet Sel Evol 37:229-51. 2005
    ..Finally, the alignment of the RH map to the assembled chicken sequence showed a small number of discordances, most of which involved the same region of the chromosome spanning between 40.5 and 75.9 cR(6000) on the RH map...
  16. ncbi Radiation hybrid mapping of 18 positional and physiological candidate genes for arthrogryposis multiplex congenita on porcine chromosome 5
    S Genini
    Institute of Animal Sciences, Breeding Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Anim Genet 37:239-44. 2006
    ..2 on SSC5 correspond to HSA12p13 and HSA12q12. We identified seven distinct chromosomal blocks, further supporting extensive rearrangements between genes on HSA12 and HSA22 in the AMC region on SSC5...
  17. ncbi Conservation of Mhc class III region synteny between zebrafish and human as determined by radiation hybrid mapping
    H Sultmann
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Germany
    J Immunol 165:6984-93. 2000
    ..This gene assembly presumably represents the pre-MHC: that existed before the class I/II genes arose. The pre-MHC: may not have contained the complement and other class III genes involved in immune response...
  18. pmc Survey sequencing and radiation hybrid mapping to construct comparative maps
    Christophe Hitte
    CNRS, Université de Rennesl, Rennes Cedex, France
    Methods Mol Biol 422:65-77. 2008
    ....
  19. ncbi Radiation hybrid mapping and comparative sequence analysis of bovine RIG-I and MAVS genes
    Edward J Cargill
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    DNA Seq 17:314-8. 2006
    ..RIG-I exon 14 and partial MAYS exon five were conserved in all samples examined. One T-A transversion SNP was found in intronic sequence downstream of RIG-I exon 14...
  20. ncbi Mapping of 443 porcine EST improves the comparative maps for SSC1 and SSC7 with the human genome
    O Demeure
    Institut National de la Recherche Agronomique, Laboratoire de Genetique Cellulaire, 31326 Castanet Tolosan, BP52627, France
    Anim Genet 36:381-9. 2005
    ..Our porcine/human comparative mapping results reveal possible new homologies for SSC1, SSC3, SSC5, SSC6, SSC12 and SSC14 and add markers in synteny breakpoints for chromosome 7...
  21. ncbi Radiation hybrid mapping and genomic organization of canine TBX2 and TBX4
    G Andelfinger
    Cardiovascular Genetics, Division of Cardiology, Cincinnati Children s Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Anim Genet 34:307-9. 2003
  22. pmc DNA repair and crossing over favor similar chromosome regions as discovered in radiation hybrid of Triticum
    Ajay Kumar
    Department of Plant Sciences, North Dakota State University, Fargo, ND 58102, USA
    BMC Genomics 13:339. 2012
    ..An in vivo RH panel was generated for mapping chromosome 3B of wheat in an attempt to provide a complete scaffold for this ~1 Gb segment of the genome and compare the resolution to previous genetic maps...
  23. ncbi A high-resolution comparative map of porcine chromosome 4 (SSC4)
    J G Ma
    Department of Biological Science and Engineering, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi an Jiaotong University, China
    Anim Genet 42:440-4. 2011
    ....
  24. ncbi Conservation of the syntenies between porcine chromosome 7 and human chromosomes 6, 14 and 15 demonstrated by radiation hybrid mapping and linkage analysis
    M Tanaka
    STAFF Institute, 446 1 Ippaizuka, Kamiyokoba, Tsukuba, Ibaraki 305 0854, Japan
    Anim Genet 34:255-63. 2003
    ..Clarification of the homology of SSC7 to human chromosomes will contribute to the elucidation of the gene(s) responsible for QTL detected on this chromosome...
  25. ncbi The first radiation hybrid map of a perch-like fish: the gilthead seabream (Sparus aurata L)
    Fabrice Senger
    CNRS UMR 6061 Génétique et Développement, Universite de Rennes 1, Faculte de Medecine, 2 Avenue du Pr Leon Bernard, 35043 Rennes Cedex, France
    Genomics 87:793-800. 2006
    ..Development of RH maps in a cost-effective manner for other fishes with the described methodology will offer a powerful approach in aquaculture and will provide extended capabilities for comparing vertebrate genome evolution...
  26. pmc Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids
    Christopher C Park
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 40:421-9. 2008
    ..Further, this work identifies 2,761 trans ceQTLs harboring no known genes, and provides evidence for a mode of gene expression autoregulation specific to the X chromosome...
  27. ncbi Exploiting plant somatic radiation hybrids for physical mapping of expressed sequence tags
    J Wardrop
    Scottish Crop Research Institute, Invergowrie, Dundee, DD2 5DA, UK
    Theor Appl Genet 108:343-8. 2004
    ..Using panels of hybrids and ESTs, donor DNA retention and individual marker retention frequencies for the expressed portion of the barley genome in the hybrids were estimated...
  28. ncbi Development of a gene-based radiation hybrid map of chicken Chromosome 7 and comparison to human and mouse
    Mireille Morisson
    Laboratoire de Genetique Cellulaire, INRA, Chemin de Borde Rouge, 31326, Castanet Tolosan, France
    Mamm Genome 15:732-9. 2004
    ..The marker order is in good agreement with the genetic map and comparison with the human and mouse sequence maps revealed a number of internal rearrangements...
  29. ncbi Linkage and radiation hybrid mapping of the porcine calsequestrin 1 (CASQ1 ) gene to chromosome 4q
    A Knoll
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 277 21 Libechov, Czech Republic
    Anim Genet 33:390-2. 2002
  30. ncbi Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17
    D J Sidjanin
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Genomics 81:138-48. 2003
    ..This order and orientation are preliminary, as high-throughput genomic sequencing of HSA17q-ter has not been fully completed...
  31. pmc A gene-based high-resolution comparative radiation hybrid map as a framework for genome sequence assembly of a bovine chromosome 6 region associated with QTL for growth, body composition, and milk performance traits
    Rosemarie Weikard
    Forschungsinstitut fur die Biologie landwirtschaftlicher Nutztiere FBN, 19196 Dummerstorf, Germany
    BMC Genomics 7:53. 2006
    ..A comprehensive high-resolution gene-rich map linking densely spaced bovine markers and genes to the annotated human genome sequence is required as a framework to facilitate this approach for the region on BTA6 carrying the QTL...
  32. pmc A high-resolution radiation hybrid map of chicken chromosome 5 and comparison with human chromosomes
    Frederique Pitel
    Laboratoire de Genetique Cellulaire, INRA, Castanet Tolosan, 31326, France
    BMC Genomics 5:66. 2004
    ..Finally, this RH map was used for testing the accuracy of the chicken genome assembly for chromosome 5...
  33. pmc A second generation radiation hybrid map to aid the assembly of the bovine genome sequence
    Oliver C Jann
    Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian, Edinburgh, EH25 9PS, UK
    BMC Genomics 7:283. 2006
    ..The radiation hybrid (RH) map described here has been contributed to the international sequencing project to aid this process...
  34. pmc Radiation hybrid mapping of the species cytoplasm-specific (scsae) gene in wheat
    Khwaja G Hossain
    Department of Plant Sciences, North Dakota State University, Fargo 58105, USA
    Genetics 168:415-23. 2004
    ..A radiation hybrid mapping population was developed from a hemizygous (lo) scsae--line using 35 krad gamma rays...
  35. ncbi A high-resolution radiation hybrid map of porcine chromosome 6
    H Cao
    Department of Animal and Poultry Science, University of Guelph, Ontario, Canada
    Anim Genet 35:367-78. 2004
    ....
  36. ncbi Use of flow-sorted canine chromosomes in the assignment of canine linkage, radiation hybrid, and syntenic groups to chromosomes: refinement and verification of the comparative chromosome map for dog and human
    D R Sargan
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 OES, England
    Genomics 69:182-95. 2000
    ..The positions of the remaining homologous segments were confirmed in new cross-species chromosome-painting experiments (dog-on-human, fox-on-human)...
  37. ncbi Statistical confidence measures for genome maps: application to the validation of genome assemblies
    Bertrand Servin
    INRA Toulouse Laboratoire de Génétique Cellulaire, Castanet Tolosan, France
    Bioinformatics 26:3035-42. 2010
    ..However, current mapping approach lack statistical confidence measures necessary to identify precisely relevant inconsistencies between a genome map and an assembly...
  38. ncbi A method to produce radiation hybrids for the D-genome chromosomes of wheat (Triticum aestivum L.)
    O Riera-Lizarazu
    Department of Crop and Soil Science, Oregon State University, Corvallis, OR 97331 3002, USA
    Cytogenet Genome Res 129:234-40. 2010
    ..On the other hand, the chromosomes from the D-genome are present in one copy (hemizygous) and allow radiation hybrid mapping of all D-genome chromosomes simultaneously...
  39. ncbi Integration of porcine chromosome 13 maps
    M Van Poucke
    Department of Animal Nutrition, Genetics, Breeding and Ethology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Cytogenet Cell Genet 93:297-303. 2001
    ..This integrated map will give us the opportunity to take maximal advantage of the comparative mapping strategy for positional candidate cloning of genes responsible for economically important traits...
  40. pmc Wide-cross whole-genome radiation hybrid mapping of cotton (Gossypium hirsutum L.)
    Wenxiang Gao
    Department of Soil and Crop Sciences, Texas A and M University, College Station, Texas 77843 2474, USA
    Genetics 167:1317-29. 2004
    ..The results demonstrate not only the feasibility of WWRH panel construction and mapping, but also complementarity to traditional linkage mapping and cytogenetic methods...
  41. ncbi Assignment of 12 genes to porcine chromosome 1 by linkage and radiation hybrid mapping
    D Nonneman
    USDA, ARS, US Meat Animal Research Center, PO Box 166, Clay Center, NE 68933 0166, USA
    Anim Genet 36:532-3. 2005
  42. pmc Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome
    Steven P Wilder
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK
    Genome Res 14:758-65. 2004
    ..The integration of rat linkage maps in the draft genomic sequence of the rat and that of other species represents an essential step for translating rat QTL intervals into human chromosomal targets...
  43. pmc A high-resolution whole-genome cattle-human comparative map reveals details of mammalian chromosome evolution
    Annelie Everts-van der Wind
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 102:18526-31. 2005
    ....
  44. ncbi A physical map of large segments of pig chromosome 7q11-q14: comparative analysis with human chromosome 6p21
    Angela Barbosa
    Laboratoire mixte de Radiobiologie et d Etude du Génome, Institut National de la Recherche Agronomigue et Center d Energie Atomique, Domaine de Vilvert, 78352, Jouy en Josas Cedex, France
    Mamm Genome 15:982-95. 2004
    ..In addition, 18 new polymorphic microsatellites have been selected in order to cover the entire SSC7p11-q14 region...
  45. pmc Dissecting the maize genome by using chromosome addition and radiation hybrid lines
    Ralf G Kynast
    Department of Agronomy and Plant Genetics and Center for Microbial and Plant Genomics, University of Minnesota, 1991 Upper Buford Circle, St Paul, MN 55108, USA
    Proc Natl Acad Sci U S A 101:9921-6. 2004
    ..These oat-maize RH lines provide valuable tools for physical mapping of the complex highly duplicated maize genome and for unique studies of inter-specific gene interactions...
  46. pmc A gene-based radiation hybrid map of the gilthead sea bream Sparus aurata refines and exploits conserved synteny with Tetraodon nigroviridis
    Elena Sarropoulou
    Institute of Marine Biology and Genetics, Hellenic Center for Marine Research, Crete, Greece
    BMC Genomics 8:44. 2007
    ....
  47. ncbi A high-resolution comparative map between pig chromosome 17 and human chromosomes 4, 8, and 20: identification of synteny breakpoints
    Yvette Lahbib-Mansais
    Institut National de la Recherche Agronomique, Laboratoire de Genetique Cellulaire, BP 52627, 31326 Castanet Tolosan, France
    Genomics 86:405-13. 2005
    ..The homology of the SSC17 pericentromeric region was extended to other human chromosomes (HSA4, HSA8) and the chromosomal breakpoint boundaries were accurately defined. In total 15 breakpoints were identified...
  48. ncbi Wide-cross whole-genome radiation hybrid mapping of the cotton (Gossypium barbadense L.) genome
    Wenxiang Gao
    Department of Soil and Crop Sciences, Texas A and M University, College Station, 77843 2474, USA
    Mol Genet Genomics 275:105-13. 2006
    Whole-genome radiation hybrid mapping has been applied extensively to human and certain animal species, but little to plants. We recently demonstrated an alternative mapping approach in cotton (Gossypium hirsutum L...
  49. ncbi A radiation hybrid map of bovine X chromosome (BTAX)
    M Elisabete J Amaral
    Departamento de Biologia, IBILCE UNESP, Sao Jose Rio Preto, SP, 15054 000, Brazil
    Mamm Genome 13:268-71. 2002
    ..Inversions of three blocks account for the difference in gene order across the entirety of the two X Chrs...
  50. ncbi Comparative mapping of the fragile histidine triad (FHIT) gene in cattle, river buffalo, sheep and goat by FISH and assignment to BTA22 by RH-mapping: a comparison with HSA3
    G P Di Meo
    National Research Council CNR, ISPAAM, Laboratory of Animal Cytogenetics and Gene Mapping, Naples, Italy
    Anim Genet 36:363-4. 2005
  51. ncbi A bovine whole-genome radiation hybrid panel and outline map
    John L Williams
    Roslin Institute Edinburgh, Roslin, Midlothian, Scotland EH25 9PS, United Kingdom
    Mamm Genome 13:469-74. 2002
    ..A large quantity of DNA has been prepared from the cells forming the RH panel reported here and is publicly available for mapping large numbers of loci...
  52. pmc ChickRH6: a chicken whole-genome radiation hybrid panel
    Mireille Morisson
    Laboratoire de Genetique Cellulaire, Institut National de la Recherche Agronomique, 31326 Castanet Tolosan, France
    Genet Sel Evol 34:521-33. 2002
    ..9%, were selected for the final panel. This panel will be a valuable resource for fine mapping of markers and genes in the chicken, and will also help in building BAC contigs...
  53. ncbi An extensive and comprehensive radiation hybrid map of bovine Chromosome 15: comparison with human Chromosome 11
    Mathieu Gautier
    Laboratoire de Génétique Biochimique et de Cytogénétique, Département de Génétique Animale, INRA CRJ, 78350 Jouy en Josas, France
    Mamm Genome 13:316-9. 2002
    ..It should, therefore, constitute a powerful tool in the identification of relevant candidate genes in regions of BTA15 harboring economic trait loci...
  54. ncbi A radiation hybrid map of chicken Chromosome 4
    Tarik S K M Rabie
    Wageningen Institute of Animal Sciences, Animal Breeding and Genetics Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    Mamm Genome 15:560-9. 2004
    ..This enhanced comparative mapping resolution enabled the identification of multiple rearrangements between GGA4 and human Chromosomes 4q and Xp...
  55. ncbi A first-generation EST RH comparative map of the porcine and human genome
    Anette Rink
    Department of Animal Biotechnology, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, Nevada 89557, USA
    Mamm Genome 13:578-87. 2002
    ..Porcine Chrs 1, 8, 11, and X display a low DNA/marker ratio and correspond to the 'genome deserts' on HSA 18, 4, 13, and X...
  56. ncbi Construction of a 5000(rad) whole-genome radiation hybrid panel in the horse and generation of a comprehensive and comparative map for ECA11
    Bhanu P Chowdhary
    Division of Animal Genetics, The Royal Veterinary and Agricultural University, Grønnegårdsvej 3, 1870, Frederiksberg, Denmark
    Mamm Genome 13:89-94. 2002
    ..A comparative status of the ECA11 map in relation to the corresponding human/mouse chromosome is presented...
  57. ncbi Application of AFLP technology to radiation hybrid mapping
    C Gorni
    Institute of Zootechnics, Catholic University of Sacred Heart, via E Parmense, 84, 29100 Piacenza, Italy
    Chromosome Res 12:285-97. 2004
    ..The use of AFLP markers as anchor points between existing RH maps and other physical maps, such as BAC contigs, is also discussed...
  58. ncbi Piggy-BACing the human genome II. A high-resolution, physically anchored, comparative map of the porcine autosomes
    Stacey N Meyers
    University of Illinois at Urbana Champaign, 220 Edward R Madigan Laboratory, MC 051, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Genomics 86:739-52. 2005
    ....
  59. ncbi High-resolution comprehensive radiation hybrid maps of the porcine chromosomes 2p and 9p compared with the human chromosome 11
    W S Liu
    Department of Dairy and Animal Science, College of Agricultural Sciences, Pennsylvania State University, University Park, PA, USA
    Cytogenet Genome Res 120:157-63. 2008
    ....
  60. pmc A cattle-human comparative map built with cattle BAC-ends and human genome sequence
    Denis M Larkin
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, 61801 USA
    Genome Res 13:1966-72. 2003
    ..The BAC clone-based comparative map provides a foundation for the evolutionary analysis of mammalian karyotypes and for sequencing of the cattle genome...
  61. pmc A high resolution physical and RH map of pig chromosome 6q1.2 and comparative analysis with human chromosome 19q13.1
    Flávia Martins-Wess
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, 30559 Hannover, Germany
    BMC Genomics 4:20. 2003
    ..The recently constructed porcine IMNpRH2 panel allowed us to use this approach for the construction of high-resolution physical maps of SSC 6q1.2...
  62. pmc A physical map of the bovine genome
    Warren M Snelling
    USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933, USA
    Genome Biol 8:R165. 2007
    ..The BAC libraries and clone maps are essential for the hybrid clone-by-clone/whole-genome shotgun sequencing approach taken by the bovine genome sequencing project...
  63. ncbi Identification of single nucleotide polymorphisms in the bovine CCL2, IL8, CCR2 and IL8RA genes and their association with health and production in Canadian Holsteins
    I Leyva-Baca
    Department of Animal and Poultry Science, Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON N1G2W1, Canada
    Anim Genet 38:198-202. 2007
    ..04 +/- 0.02, P = 0.05), which might indicate a possible association in support of other published studies. Lastly, we assigned CCR2 to BTA22q24, where a previously QTL for SCS was identified...
  64. pmc The comprehensive mouse radiation hybrid map densely cross-referenced to the recombination map: a tool to support the sequence assemblies
    Lucy B Rowe
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 13:122-33. 2003
    ..We have compared these linked framework maps to the Ensemble mouse genome sequence assembly, and show that they are a useful medium resolution tool for both validating sequence assembly and elucidating chromosome biology...
  65. ncbi Association of ZYX polymorphisms with carcass and meat quality traits in commercial pigs
    T Srikanchai
    Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Meat Sci 84:159-64. 2010
    ..However, the lack of consistent association across all pig populations in this study indicates that the association of the SNPs may be depending on causal mutations in linkage disequilibrium and/or interactions with other loci...
  66. pmc Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes
    M Breen
    Genetics Section, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    Genome Res 11:1784-95. 2001
    ....
  67. ncbi A 12,000-rad porcine radiation hybrid (IMNpRH2) panel refines the conserved synteny between SSC12 and HSA17
    Wan Sheng Liu
    Department of Animal Biotechnology, College of Agriculture, Biotechnology, and Natural Resources, University of Nevada at Reno, Mail Stop 202, 1664 N Virginia Street, Reno, NV 89557, USA
    Genomics 86:731-8. 2005
    ..A high-resolution SSC12 RH12,000-rad map will be useful in fine-mapping QTL and as a scaffold for sequencing this chromosome...
  68. ncbi Radiation hybrid map of the porcine genome comprising 2035 EST loci
    Anette Rink
    Department of Animal Biotechnology, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, Nevada 89557, USA
    Mamm Genome 17:878-85. 2006
    ....
  69. pmc A radiation hybrid map of river buffalo (Bubalus bubalis) chromosome 1 (BBU1)
    M N Miziara
    Departamento Biologia, UNESP Sao Paulo State University, IBILCE, Sao Jose Rio Preto, Brazil
    Cytogenet Genome Res 119:100-4. 2007
    ..The BBU1 map provides a starting point for comparison of gene order rearrangements between river buffalo chromosome 1 and its bovine homologs...
  70. ncbi A refined comparative map between porcine chromosome 13 and human chromosome 3
    M Van Poucke
    Department of Animal Nutrition, Genetics, Breeding and Ethology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Cytogenet Genome Res 102:133-8. 2003
    ..Sequence comparison of the BAC end sequences with the human genome sequence showed that the centromeric part of SSC13 is homologous with HSA3p24...
  71. ncbi Linkage mapping of the primary disease locus for collie eye anomaly
    Jennifer K Lowe
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, USA
    Genomics 82:86-95. 2003
    ..076), in a region corresponding to human chromosome 2q35. These results suggest the presence of a developmental regulatory gene important in ocular embryogenesis, with potential implications for other disorders of ocular vascularization...
  72. ncbi A comprehensive radiation hybrid map of the bovine genome comprising 5593 loci
    Tomohito Itoh
    Shirakawa Institute of Animal Genetics, Odakura, Nishigo, Nishi shirakawa, Fukushima 961 8061, Japan
    Genomics 85:413-24. 2005
    ..In summary, the new, high-resolution SUNbRH7000-rad, comparative, Shirakawa-USDA linkage, and BAC fingerprint maps provide a set of genomic tools for fine mapping regions of interest in cattle...
  73. ncbi Porcine TLR2 and TLR6: identification and their involvement in Mycoplasma hyopneumoniae infection
    Yoshihiro Muneta
    Department of Immunology, National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Interferon Cytokine Res 23:583-90. 2003
    ..1 --> 21.5; TLR6: SSC8p11.1 --> p21.1) by fluorescence in situ hybridization (FISH) and radiation hybrid mapping. Western blot analysis confirmed that TLR2 and TLR6 proteins were both expressed in porcine alveolar ..
  74. pmc A 1463 gene cattle-human comparative map with anchor points defined by human genome sequence coordinates
    Annelie Everts-van der Wind
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Genome Res 14:1424-37. 2004
    ....
  75. ncbi Improving the comparative map of porcine chromosome 10 with respect to human chromosomes 1, 9 and 10
    J Aldenhoven
    Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia
    Cytogenet Genome Res 102:121-7. 2003
    ..Two anonymous markers were also physically mapped to SSC10 (SWR1849 and S0070) to better connect the physical and linkage maps. These assignments have further refined the comparative map between SSC1, 4 and 10 and HSA1, 9 and 10...
  76. ncbi Comparative mapping of human chromosome 10 to pig chromosomes 10 and 14
    D Nonneman
    USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933 0166, USA
    Anim Genet 35:338-43. 2004
    ..Development of comparative maps containing several species should reveal conserved syntenic blocks that will allow us to better define QTL regions in livestock...
  77. pmc Addition of the microchromosome GGA25 to the chicken genome sequence assembly through radiation hybrid and genetic mapping
    Marine Douaud
    UMR INRA ENVT Laboratoire de Génétique Cellulaire, INRA, Castanet Tolosan, 31326, France
    BMC Genomics 9:129. 2008
    ..The chrUn is composed of sequence contigs not assigned to named chromosomes. To identify and map sequence belonging to the microchromosomes we used a comparative mapping strategy, and we focused on the small linkage group E26C13...
  78. ncbi First radiation hybrid map of the river buffalo X chromosome (BBUX) and comparison with BTAX
    P Ianella
    Dept Biologia, IBILCE, UNESP Sao Paulo State University, Sao Jose Rio Preto, SP 15054 000, Brazil
    Anim Genet 39:196-200. 2008
    ....
  79. ncbi A new 4016-marker radiation hybrid map for porcine-human genome analysis
    Noriyuki Hamasima
    Society for Techno Innovation of Agriculture, Forestry and Fisheries STAFF Institute, 446 1 Ippaizuka, Kamiyokoba, Tsukuba, Ibaraki, 305 0854, Japan
    Mamm Genome 19:51-60. 2008
    ....
  80. pmc A high resolution radiation hybrid map of bovine chromosome 14 identifies scaffold rearrangement in the latest bovine assembly
    Elisa Marques
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
    BMC Genomics 8:254. 2007
    ..Accurately defining the marker order on chromosomes is crucial for correct identification of quantitative trait loci (QTL), haplotype map construction and refinement of candidate gene searches...
  81. ncbi Preliminary radiation hybrid map for river buffalo chromosome 6 and comparison to bovine chromosome 3
    N B Stafuzza
    Department of Biologia, UNESP Sao Paulo State University, IBILCE, Sao Jose Rio Preto, SP 15054 000, Brazil
    Anim Genet 38:406-9. 2007
    ..Also, resources for positional candidate cloning in river buffalo are enhanced...
  82. pmc rh_tsp_map 3.0: end-to-end radiation hybrid mapping with improved speed and quality control
    Alejandro A Schäffer
    National Center for Biotechnology Information, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20894, USA
    Bioinformatics 23:1156-8. 2007
    ..tar.gz. CONCORDE modified for RH mapping is available in the directory http://www.isye.gatech.edu/~wcook/rh/. The QSopt library needed for CONCORDE is available at http://www2.isye.gatech.edu/~wcook/qsopt/downloads/downloads.htm..
  83. pmc Construction of bovine whole-genome radiation hybrid and linkage maps using high-throughput genotyping
    S D McKay
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
    Anim Genet 38:120-5. 2007
    ..0) in a fraction of the time it would have taken with conventional typing and genotyping methods...
  84. ncbi Isolation and radiation hybrid mapping of 213 porcine microsatellites
    L J Alexander
    USDA ARS, LARRL, Ft Keogh, Miles City, MT 59301, USA
    Anim Genet 37:596-7. 2006
  85. ncbi SNP identification, linkage and radiation hybrid mapping of the porcine lamin A/C (LMNA) gene to chromosome 4q
    D Wagenknecht
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
    J Anim Breed Genet 123:280-3. 2006
    ..0 cM - LMNA - 0.2 cM - GBA). In radiation hybrid mapping LMNA was most significantly linked to SW270 on chromosome 4 (39 cR; LOD = 7.86)...
  86. ncbi Radiation hybrid mapping and sequence analysis of 21 genes on porcine chromosome 15
    H L Du
    Department of Animal Genetics and Breeding, College of Animal Science, South China Agricultural University, Guangzhou, MA 510642, China
    Anim Genet 37:181-3. 2006
  87. ncbi Radiation hybrid mapping of 10 genes to porcine chromosomes
    J Aldenhoven
    Centre for Advanced Technologies in Animal Genetics and Reproduction REPROGEN, Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia
    Anim Genet 36:540-2. 2005
  88. pmc A radiation hybrid map of river buffalo (Bubalus bubalis) chromosome 7 and comparative mapping to the cattle and human genomes
    T Goldammer
    Forschungsbereich Molekularbiologie, Forschungsinstitut fur die Biologie landwirtschaftlicher Nutztiere FBN, Dummerstorf, Germany
    Cytogenet Genome Res 119:235-41. 2007
    ..The data obtained in our study define the evolutionarily conserved segment on BBU7 and HSA4 to be between 3.5 megabases (Mb) and 115.8 Mb in the HSA4 (genome build 36) DNA sequence...
  89. pmc Integrating linkage and radiation hybrid mapping data for bovine chromosome 15
    Warren M Snelling
    USDA, ARS, U, S, Meat Animal Research Center, Spur 18D, Clay Center, Nebraska 68933 0166, USA
    BMC Genomics 5:77. 2004
    ..Automated map construction procedures employing this maximum-likelihood approach were developed to integrate BTA RH and linkage data, and establish comparative positions of BTA 15 markers with HSA 11 homologs...
  90. ncbi A high-resolution physical map of equine homologs of HSA19 shows divergent evolution compared with other mammals
    Candice Brinkmeyer-Langford
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, 77843, USA
    Mamm Genome 16:631-49. 2005
    ....
  91. pmc An integrated 4249 marker FISH/RH map of the canine genome
    Matthew Breen
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    BMC Genomics 5:65. 2004
    ..Understanding the genetic basis of both phenotypic variation and disease susceptibility in the dog provides new ways in which to dissect the genetics of human health and biology...
  92. ncbi The chicken RH map: current state of progress and microchromosome mapping
    M Morisson
    INRA, UR444 Laboratoire de Génétique Cellulaire, Castanet Tolosan, France
    Cytogenet Genome Res 117:14-21. 2007
    ..This will help finish the mapping of the smallest gene-rich microchromosomes...
  93. ncbi An integrated comparative map of the porcine X chromosome
    S A McCoard
    USDA ARS US Meat Animal Research Center, Clay Center, NE 68933 0166, USA
    Anim Genet 33:178-85. 2002
    ..This integrated map will be valuable for selection of candidate genes for porcine quantitative trait loci (QTLs) that map to SSC-X...
  94. ncbi A high-resolution comparative RH map of porcine chromosome (SSC) 2
    A P Rattink
    Department of Animal Sciences, Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, PO Box 338, 6700 AH, Wageningen, The Netherlands
    Mamm Genome 12:366-70. 2001
    ..5. The boundaries of the conserved segments between human and pig were defined more precisely. This high-resolution comparative map will be a valuable tool for further fine mapping of the QTL area...
  95. ncbi Radiation hybrid mapping of genes showing intramuscular fat deposition-associated expression changes in bovine musculus longissimus muscle
    T Yamada
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Anim Genet 37:184-5. 2006
  96. ncbi A physical map of the mouse genome
    Simon G Gregory
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 418:743-50. 2002
    ..The human sequence may be used to facilitate construction of other mammalian genome maps using the same strategy...
  97. ncbi Characterization and radiation hybrid mapping of expressed sequence tags from the canine brain
    Monica C Roberts
    College of Veterinary Medicine, Department of Veterinary Pathobiology, University of Minnesota, 1988 Fitch Avenue, 295 Animal Science Veterinary Medicine, St Paul 55108, USA
    Mamm Genome 14:203-13. 2003
    ..This work has increased the number of gene-based markers on the canine RH map by approximately 30% and indicates the benefit to be gained by increasing the gene content of the current canine comparative map...
  98. pmc The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes
    Bhanu P Chowdhary
    Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Genome Res 13:742-51. 2003
    ....
  99. ncbi Radiation hybrid mapping of 118 new porcine microsatellites
    A Korwin-Kossakowska
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA
    Anim Genet 33:224-7. 2002
  100. ncbi Construction of a new porcine whole-genome framework map using a radiation hybrid panel
    N Hamasima
    Animal Genome Research Program Team AGP, STAFF Institute, Tsukuba, Ibaraki 305 0854, Japan
    Anim Genet 34:216-20. 2003
    ..6%. The total map length was 5596.2 centiRay (cR). Using an estimated physical length of 2718 Mbp, the average ratio between cR and physical distance over the porcine genome was estimated to be 0.49 Mb/cR...
  101. ncbi Targeted construction of a high-resolution, integrated, comprehensive, and comparative map for a region specific to bovine chromosome 6 based on radiation hybrid mapping
    Rosemarie Weikard
    Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, 18196 Dummerstorf, Germany
    Genomics 79:768-76. 2002
    ..Due to its links to the gene-dense maps of human and mouse, it can serve as a prerequisite to identify possible candidate genes for quantitative trait loci localized in the targeted BTA6 region...

Research Grants30

  1. MAPPING AND SEQUENCING THE HUMAN GENOME
    Richard Myers; Fiscal Year: 1999
    ..Project 2 will use radiation hybrid mapping of these STSs to generate a contiguous physical map of the human genome with an average resolution of 100 ..
  2. MOLECULAR GENETICS OF BIPOLAR AFFECTIVE DISORDER
    Charles Richard; Fiscal Year: 1993
    ..and other known chromosome 11 markers by a somatic cell genetic technique developed in this lab known as "radiation hybrid mapping"...
  3. INTEGRATED ZEBRAFISH GENOMIC RESOURCES
    Stephen Johnson; Fiscal Year: 2003
    ..2) STS development and Radiation Hybrid mapping. We will generate 10,000 STS markers from 3' EST reads and genotype 5,000 STSs on a Radiation Hybrid ..
  4. ANALYSIS OF KILLER CELL INHIBITORY RECEPTOR COMPLEX
    David Lawlor; Fiscal Year: 1999
    ..DNA clones that derive from the relevant region of chromosome 19, as deduced from preliminary radiation hybrid mapping experiments, are freely obtainable from several genome centers...
  5. COMPARATIVE HYBRIDIZATION OF AP PCR ARRAYS
    SERGEI MALKHOSYAN; Fiscal Year: 2000
    ..fragments will be determined by hybridizing the array with AP-PCR products from individual clones of radiation hybrid mapping panels...
  6. COMPARATIVE HYBRIDIZATION OF AP PCR ARRAYS
    SERGEI MALKHOSYAN; Fiscal Year: 2003
    ..fragments will be determined by hybridizing the array with AP-PCR products from individual clones of radiation hybrid mapping panels...
  7. NF2 BINDING PROTEINS
    Stefan Pulst; Fiscal Year: 2000
    ..2) Full length cDNAs for SBkPs will obtained and mapped to human chromosome regions using FISH and radiation hybrid mapping. tissue and subcellular distribution of SBPs by Northern and Western blot analyses as well as ..
  8. MOLECULAR GENETICS OF PAR-3
    Lisa Cupit; Fiscal Year: 2004
    ..Genetic linkage analysis using radiation hybrid mapping panels localized the PAR-3 gene to the PAR gene cluster at 5q13, a site at or contiguous to the common ..
  9. IDENTIFICATION AND EXPRESSION OF SKIN SPECIFIC GENES
    Peter Byers; Fiscal Year: 2002
    ..Genes will be mapped either by bioinformatic procedures or by radiation hybrid mapping to identify candidates for yet uncharacterized genetic disorders...
  10. HIGH EFFICIENCY MAPPING WITH A HUMAN MICROCELL PANEL
    Ann Killary; Fiscal Year: 1992
    ..will also be determined for the most efficient utilization of microcell hybrids as donor cells for radiation hybrid mapping. Radiation hybrids will be made in a variety of cell lines...
  11. HIGH THROUGHPUT ANNOTATION OF GENOMIC DNA SEQUENCE
    Christian Stoeckert; Fiscal Year: 2003
    ..b>Radiation hybrid mapping data for mouse sequences will be incorporated as has been done for human ESTs...
  12. MOUSE GENETIC MAPPING RESOURCE
    Janan Eppig; Fiscal Year: 2001
    ..Community backcross and radiation hybrid mapping resources that provide common mapping reagents and associated databases provide the underpinnings to ..
  13. The Rutgers Mapping Resources
    Tara C Matise; Fiscal Year: 2010
    ..Our proposal is submitted under PAR-05-057 "Continued development and maintenance of software," which aims to "support the continued development, maintenance, testing and evaluation of existing software." ..
  14. Analysis of Folate Receptor 4 Function in the Mouse
    J Salbaum; Fiscal Year: 2006
    ..Together, these studies will improve our understanding of the basic biology of folate receptor genes, with implications for the prevention of human birth defects. ..
  15. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2007
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  16. Molecular mechanisms of anterograde transport
    Elaine Bearer; Fiscal Year: 2007
    ..Thus, these results will yield answers to universal questions on axonal transport, specific facts about herpes pathogenesis, and fundamental new information about the role of APP in Alzheimer's disease. [unreadable] [unreadable]..
  17. CIC-3 chloride ion channels in vascular smooth muscle
    Fred Lamb; Fiscal Year: 2007
    ..Careful analysis of the physiological defects in Clcn3-/- mice will yield important insight into cellular ROS metabolism and the link between ROS and high blood pressure. ..
  18. Shared Zeiss 510META Confocal Microscope
    Elaine Bearer; Fiscal Year: 2008
    ..Their research applications address fundamental questions regarding prevalent disease with important impacts on public health. [unreadable] [unreadable] [unreadable]..
  19. The Genetics of Female Reproductive Aging
    Tara Matise; Fiscal Year: 2008
    ..Finally, enhancing our understanding of reproductive senescence may facilitate improvements in technologies used for assisted reproduction. [unreadable] [unreadable] [unreadable]..
  20. Sequencing the Chimpanzee Y Chromosome
    Jennifer Hughes; Fiscal Year: 2005
    ..However, because of several unique challenges posed by the Y chromosome, a dedicated effort will be required to obtain a complete and accurate sequence of this distinctive region of the chimpanzee genome. ..
  21. Role of Na+ Transporter Genes in Essential Hypertension
    Nelson Ruiz Opazo; Fiscal Year: 2005
    ....
  22. INTEGRATED MAPS USING RADIATION HYBRIDS
    Tara Matise; Fiscal Year: 2002
    ..She will also use these tools to participate in a recently begun mouse genome radiation hybrid mapping project...
  23. MOLECULAR MECHANISMS OF ACTIN DYNAMICS IN PLATELETS
    Elaine Bearer; Fiscal Year: 2003
    ..In other studies the dynamics of green fluorescent protein (GFP)-labeled 2E4 and Arp2 will be followed by real time video microscopy in cultured fibroblasts. ..
  24. Discovery and functional assessment of the rat op gene
    DAVID DOBBINS; Fiscal Year: 2004
    ..abstract_text> ..
  25. Molecular Genetics of the ET-1/AngII Receptor
    Nelson Ruiz Opazo; Fiscal Year: 2005
    ....
  26. Canine Brain Tumors - A New Model for Gene Discovery
    Matthew Breen; Fiscal Year: 2006
    ..Characterization of these genetic loci will help to improve the definition of molecular risk and prognosis of human and canine brain tumors, with a potentially major impact on human health. ..
  27. ANG II AND AVP ISORECEPTORS IN BLOOD PRESSURE
    Nelson Ruiz Opazo; Fiscal Year: 2002
    ....
  28. GLUCOCORTICOID ATTENUATED RESPONSE GENES IN INFLAMMATION
    Jeffrey Smith; Fiscal Year: 2001
    ..Genes identified in this search are likely to encode pro-inflammatory mediators that participate in a wide range of inflammatory lung diseases in addition to endotoxemia. ..
  29. The molecular basis for an animal model of inherited hyperuricosuria
    Danika Bannasch; Fiscal Year: 2007
    ..The elucidation of a novel gene function should provide new avenues of investigation for the treatment of the human condition. [unreadable] [unreadable] [unreadable]..