transplantation

Summary

Summary: Transference of a tissue or organ, alive or dead, within an individual, between individuals of the same species, or between individuals of different species.

Top Publications

  1. doi Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
    J L Anderson
    Diabetes and Nutritional Sciences Division, School of Medicine, King s College London, London, UK
    Aliment Pharmacol Ther 36:503-16. 2012
  2. doi Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury
    B M Buchholz
    Division of Gastroenterology, Department of Medicine, Hepatology and Nutrition, Thomas E Starzi Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 8:2015-24. 2008
  3. doi The microbiome and inflammatory bowel disease: is there a therapeutic role for fecal microbiota transplantation?
    Christopher J Damman
    Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Gastroenterol 107:1452-9. 2012
  4. pmc Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells
    Torsten Bunde
    Institut fur Medizinische Immunologie, Charite, Universitatsmedizin Berlin, Campus Mitte, 10098 Berlin, Germany
    J Exp Med 201:1031-6. 2005
  5. ncbi Engraftment of distinct clonal MDS-derived hematopoietic precursors in NOD/SCID-beta2-microglobulin-deficient mice after intramedullary transplantation of hematopoietic and stromal cells
    Daniella M Bahia Kerbauy
    Blood 104:2202-3. 2004
  6. doi Biomarker assessment of the immunomodulator effect of atorvastatin in stable renal transplant recipients and hypercholesterolemic patients
    David Guillen
    Pharmacology Laboratory Biomedical Diagnosis Center, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Mol Diagn Ther 14:357-66. 2010
  7. doi Systemic complement activation in deceased donors is associated with acute rejection after renal transplantation in the recipient
    Jeffrey Damman
    Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 92:163-9. 2011
  8. doi West Nile virus transmission through organ transplantation in north-eastern Italy: a case report and implications for pre-procurement screening
    W O Inojosa
    Treviso Hospital, Treviso, Italy
    Infection 40:557-62. 2012
  9. doi Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis
    Patrizia K Kump
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Inflamm Bowel Dis 19:2155-65. 2013
  10. pmc HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients
    Danielle M Zerr
    Department of Pediatrics, University of Washington, Seattle, WA, USA
    Blood 117:5243-9. 2011

Research Grants

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
  4. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
  5. Yasmin Wadia; Fiscal Year: 2014
  6. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
  7. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
  8. Sogol Mostoufi-Moab; Fiscal Year: 2016
  9. MERVYN N WEITZMANN; Fiscal Year: 2016
  10. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010

Detail Information

Publications277 found, 100 shown here

  1. doi Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
    J L Anderson
    Diabetes and Nutritional Sciences Division, School of Medicine, King s College London, London, UK
    Aliment Pharmacol Ther 36:503-16. 2012
    The intestinal microbiota is involved in the pathogenesis of inflammatory bowel disease (IBD). Faecal microbiota transplantation (FMT) has been used for the management of IBD as well as infectious diarrhoea.
  2. doi Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury
    B M Buchholz
    Division of Gastroenterology, Department of Medicine, Hepatology and Nutrition, Thomas E Starzi Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 8:2015-24. 2008
    Ischemia/reperfusion (I/R) injury during small intestinal transplantation (SITx) frequently causes complications including dysmotility, inflammation and organ failure...
  3. doi The microbiome and inflammatory bowel disease: is there a therapeutic role for fecal microbiota transplantation?
    Christopher J Damman
    Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Gastroenterol 107:1452-9. 2012
    ..Further clinical studies are justified, and could be complemented by mouse models of fecal transplantation, in which variables can be controlled and manipulated.
  4. pmc Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells
    Torsten Bunde
    Institut fur Medizinische Immunologie, Charite, Universitatsmedizin Berlin, Campus Mitte, 10098 Berlin, Germany
    J Exp Med 201:1031-6. 2005
    ..In conclusion, high frequencies of IE-1 but not pp65-specific CD8 T cells correlate with protection from CMV disease. These results have important implications for monitoring T cell responses, adoptive cell therapy, and vaccine design...
  5. ncbi Engraftment of distinct clonal MDS-derived hematopoietic precursors in NOD/SCID-beta2-microglobulin-deficient mice after intramedullary transplantation of hematopoietic and stromal cells
    Daniella M Bahia Kerbauy
    Blood 104:2202-3. 2004
  6. doi Biomarker assessment of the immunomodulator effect of atorvastatin in stable renal transplant recipients and hypercholesterolemic patients
    David Guillen
    Pharmacology Laboratory Biomedical Diagnosis Center, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Mol Diagn Ther 14:357-66. 2010
    ..However, the role of statins in the immunosuppressive response that is achieved in individual patients remains to be assessed...
  7. doi Systemic complement activation in deceased donors is associated with acute rejection after renal transplantation in the recipient
    Jeffrey Damman
    Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 92:163-9. 2011
    Acute rejection after renal transplantation has been shown to be negatively associated with long-term graft survival...
  8. doi West Nile virus transmission through organ transplantation in north-eastern Italy: a case report and implications for pre-procurement screening
    W O Inojosa
    Treviso Hospital, Treviso, Italy
    Infection 40:557-62. 2012
    West Nile virus (WNV) transmission through organ transplantation occurs rarely and screening of organ donors for WNV infection remains controversial...
  9. doi Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis
    Patrizia K Kump
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Inflamm Bowel Dis 19:2155-65. 2013
    ..Fecal microbiota transplantation (FMT) has been used as effective therapy for recurrent Clostridium difficile colitis also caused by dysbiosis...
  10. pmc HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients
    Danielle M Zerr
    Department of Pediatrics, University of Washington, Seattle, WA, USA
    Blood 117:5243-9. 2011
    ..6 (HHV-6) is detected in the plasma of approximately 40% of patients undergoing hematopoietic cell transplantation (HCT) and sporadically causes encephalitis in this population...
  11. doi Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation
    Viviana Moroso
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Liver Transpl 16:895-908. 2010
    ..Animal models indicate that donor leukocytes transferred into the recipient after liver transplantation (LTX) play a relevant role in this tolerogenic phenomenon...
  12. doi Transplantation of bone-marrow-derived cells into a nerve guide resulted in transdifferentiation into Schwann cells and effective regeneration of transected mouse sciatic nerve
    Fátima Rosalina Pereira Lopes
    Instituto de Ciencias Biomedicas, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Brazil
    Micron 41:783-90. 2010
    ..Our data suggest that BMDCs transplanted into a nerve guide can differentiate into SCs, and improve the growth rate of nerve fibers and motor function in a transected sciatic-nerve model...
  13. doi Endoplasmic reticulum stress: an unrecognized actor in solid organ transplantation
    Nicolas Pallet
    INSERM U775 and Université Paris Descartes, Centre Universitaire des Saints Peres, Paris, France
    Transplantation 88:605-13. 2009
    ....
  14. ncbi Improved survival and ammonia metabolism by intraperitoneal transplantation of microencapsulated hepatocytes in totally hepatectomized rats
    Y Umehara
    Second Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Surgery 130:513-20. 2001
    BACKGROUND: We evaluated the effects of intraperitoneal transplantation of microencapsulated hepatocytes in a 3-stage total hepatectomy rat model. METHODS: A new model of total hepatectomy was created as follows...
  15. ncbi Tissue engineering: confronting the transplantation crisis
    Robert M Nerem
    Georgia Tech Emory Center For the Engineering of Living Tissue, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    Adv Exp Med Biol 534:1-9. 2003
  16. ncbi Prevention and treatment of glucocorticoid-induced osteoporosis with active vitamin D3 analogues: a review with meta-analysis of randomized controlled trials including organ transplantation studies
    R N J de Nijs
    Department of Rheumatology and Clinical Immunology, F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA, The Netherlands
    Osteoporos Int 15:589-602. 2004
    ..Meta-analysis (quantitative review) on clinical trials (including organ transplantation studies) was performed with percent change in lumbar spine bone mineral density or bone mineral content as ..
  17. ncbi Investigation of risk acceptance in hand transplantation
    Ramsey K Majzoub
    Department of Surgery, University of Louisville, Louisville, KY 40202, USA
    J Hand Surg Am 31:295-302. 2006
    ..To assess quantitatively the risks versus benefits in hand transplantation we used a validated instrument (Louisville Instrument for Transplantation) to measure the degree of risk ..
  18. ncbi Pediatric transplantation in the United States, 1996-2005
    S Horslen
    Children s Hospital and Regional Medical Center, Seattle, Washington, USA
    Am J Transplant 7:1339-58. 2007
    Solid organ transplantation is accepted as a standard lifesaving therapy for end-stage organ failure in children...
  19. ncbi Psychosocial implications of disfigurement and the future of human face transplantation
    L Allen Furr
    Department of Sociology, University of Louisville, Louisville, KY 40202, USA
    Plast Reconstr Surg 120:559-65. 2007
    ..factors that will be central for addressing the ethical and psychosocial challenges necessary to move face transplantation into mainstream medicine...
  20. doi Transplantation of the uterus in sheep: methodology and early reperfusion events
    Pernilla Dahm-Kähler
    Department of Obstetrics and Gynecology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Obstet Gynaecol Res 34:784-93. 2008
    Uterine transplantation is developing into a clinical treatment for uterine factor infertility...
  21. doi Global observatory and database on donation and transplantation: world overview on transplantation activities
    R Matesanz
    Organizacion Nacional de Trasplantes, Madrid, Spain
    Transplant Proc 41:2297-301. 2009
    The Global Database on Donation and Transplantation is one of the main areas of the Global Observatory on Donation and Transplantation (GODT), which is the information platform designed to implement some of the requirements of the World ..
  22. doi Variability and recombination of clinical human cytomegalovirus strains from transplantation recipients
    Muriel Faure-Della Corte
    PRES Université de Bordeaux, Laboratoire de Virologie EA2968 and IFR66, 33076 Bordeaux, France
    J Clin Virol 47:161-9. 2010
    ..Human cytomegalovirus (HCMV) is the first cause of viral infection in immunocompromised transplanted patients...
  23. doi Organ donation and transplantation training for future professional nurses as a health and social awareness policy
    M J López-Montesinos
    Departamento de Enfermeria, Universidad de Murcia, Espana
    Transplant Proc 42:239-42. 2010
    Training and information for university nursing students about the organ donation and transplantation process is necessary because it will influence their attitudes toward the subject...
  24. doi Patient attitudes toward the use of fecal microbiota transplantation in the treatment of recurrent Clostridium difficile infection
    Jonathan S Zipursky
    Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Clin Infect Dis 55:1652-8. 2012
    Fecal microbiota transplantation (FMT), a safe, effective alternative therapy for recurrent Clostridium difficile infection (CDI), is infrequently used, in part because of an assumption that patients are unwilling to consider FMT because ..
  25. doi Immune regulation of human herpesviruses and its implications for human transplantation
    C Smith
    Australian Centre for Vaccine Development, Tumour Immunology Laboratory, Department of Immunology, Queensland Institute of Medical Research, Brisbane, Australia
    Am J Transplant 13:9-23; quiz 23. 2013
    ....
  26. doi Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation
    Sieglinde Angelberger
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Wien, Austria
    Am J Gastroenterol 108:1620-30. 2013
    Fecal microbiota transplantation (FMT) from healthy donors, which is an effective alternative for treatment of Clostridium difficile-associated disease, is being considered for several disorders such as inflammatory bowel disease, ..
  27. pmc The survival condition and immunoregulatory function of adipose stromal vascular fraction (SVF) in the early stage of nonvascularized adipose transplantation
    Ziqing Dong
    Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guang Zhou, Guang Dong, P R, China
    PLoS ONE 8:e80364. 2013
    Adipose tissue transplantation is one of the standard procedures for soft-tissue augmentation, reconstruction, and rejuvenation. However, it is unknown as to how the graft survives after transplantation...
  28. doi Evaluation of meniscus allograft transplantation with serial magnetic resonance imaging during the first postoperative year: focus on graft extrusion
    Dae Hee Lee
    Department of Orthopedic Surgery, Korea University School of Medicine, Anam Hospital, Seoul, South Korea
    Arthroscopy 24:1115-21. 2008
    The purpose of this study was to evaluate change in meniscal allograft extrusion during the first year after meniscus allograft transplantation (MAT) by use of serial magnetic resonance imaging (MRI).
  29. pmc Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma: Report of an initial experience
    Jian Zhou
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
    World J Gastroenterol 12:3114-8. 2006
    ..To report a retrospective analysis of preliminary results of 36 patients who received sirolimus (SRL, Rapamune, rapamycin) in a consecutive cohort of 248 liver allograft recipients...
  30. doi The molecular and clinical rationale of extracorporeal photochemotherapy in autoimmune diseases, malignancies and transplantation
    Peter Szodoray
    Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
    Autoimmun Rev 9:459-64. 2010
    ..intervention, which has been introduced in a variety of hematological malignancies, autoimmune conditions and transplantation. The mode of action of photopheresis encompasses apoptosis-induction and modifications of immunoregulatory ..
  31. ncbi Surgical challenges in transplantation: the Fourth Annual American Society of Transplant Surgeons' State-of-the-Art Winter Symposium
    Sandy Feng
    Department of Surgery, Division of Transplantation, University of California San Francisco, USA
    Am J Transplant 5:428-35. 2005
  32. ncbi Costimulatory blockade with belatacept in clinical and experimental transplantation - a review
    Juliet Emamaullee
    University of Alberta, Surgery, 5 126 HRIF East, Shapiro Lab, Edmonton, Alberta T6G2E1, Canada
    Expert Opin Biol Ther 9:789-96. 2009
    ..immunosuppression agents have been critical to the improved graft and patient survival rates in solid organ transplantation observed over the past decade...
  33. doi Association between donor-specific antibodies and acute rejection and resolution in small bowel and multivisceral transplantation
    Hsin Lin Tsai
    Division of Transplantation, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Transplantation 92:709-15. 2011
    ..We carried out a prospective study to understand the impact of DSA in the setting of intestinal allograft rejection...
  34. doi How deceased donor transplantation is impacting a decline in commercial transplantation-the Tamil Nadu experience
    Georgi Abraham
    Department of Nephrology, Madras Medical Mission, Chennai, Tamil Nadu, India
    Transplantation 93:757-60. 2012
    India with a population of 1.2 billion has a renal transplantation rate of 3.25 per million population. The major cause of chronic kidney disease is hypertension and diabetes...
  35. pmc Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations
    A Sanchez-Mazas
    University of Geneva, Geneva, Switzerland
    Int J Immunogenet 39:459-72; quiz 473-6. 2012
    HLA-NET (a European COST Action) aims at networking researchers working in bone marrow transplantation, epidemiology and population genetics to improve the molecular characterization of the HLA genetic diversity of human populations, ..
  36. ncbi Probing teleost eye development by lens transplantation
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park 20742, USA
    Methods 28:420-6. 2002
    ..Here we describe a lens transplantation method for studying the role of the lens in teleost eye development...
  37. ncbi Clinical significance of donor-recipient HLA matching on survival after myeloablative hematopoietic cell transplantation from unrelated donors
    E W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA98109, USA
    Tissue Antigens 69:25-30. 2007
    The application of unrelated donor hematopoietic cell transplantation can be expanded with the use of mismatched donors if human leukocyte antigen (HLA) disparity does not lead to increased morbidity and mortality...
  38. ncbi Oogenesis in the suppressor of hairy-wing mutant of Drosophila melanogaster. I. Phenotypic characterization and transplantation experiments
    W S Klug
    J Exp Zool 167:151-6. 1968
  39. ncbi Mechanisms of ischemic preconditioning and its application in transplantation
    Maciej Kosieradzki
    Department of General and Transplantation Surgery, Medical University of Warsaw, Poland
    Ann Transplant 7:12-20. 2002
    ..from short-time ischemia and reperfusion makes clinical applications of the phenomenon, including field of transplantation medicine, highly appealing. This review summarizes known physiological pathways of ischemic preconditioning...
  40. ncbi Is posttransplant lymphoproliferative disorder (PTLD) caused by any specific immunosuppressive drug or by the transplantation per se?
    S A Birkeland
    Department of Nephrology, Odense University Hospital, Odense, Denmark
    Transplantation 76:984-8. 2003
    ..Because focus on PTLD coincided with the use of these drugs, a bias could be suspected...
  41. ncbi Microsporidiosis and transplantation: a retrospective study of 23 cases
    Meja Rabodonirina
    Service de Parasitologie, Hopital de la Croix Rousse, Lyon, France
    J Eukaryot Microbiol 50:583. 2003
  42. pmc The UK Human Tissue Act and consent: surrendering a fundamental principle to transplantation needs?
    M D D Bell
    The General Infirmary at Leeds, Great George Street, Leeds, LS1 3EX, UK
    J Med Ethics 32:283-6. 2006
  43. ncbi Platelets an inflammatory force in transplantation
    C N Morrell
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, USA
    Am J Transplant 7:2447-54. 2007
    ..These repair mechanisms could promote the replacement of donor parenchmal cells with recipient cells and contribute to vascuplopathy. This review discusses the interplay of platelets and the immune system in relation to transplantation.
  44. ncbi The effects of medial meniscal transplantation techniques on intra-articular contact pressures
    Nikhil N Verma
    Midwest Orthopedics at Rush, Rush University Medical Center, Chicago, IL 60612, USA
    J Knee Surg 21:20-6. 2008
    This study aimed to compare medial compartment contact pressures in knees treated with medial meniscal transplantation using either a bone plug or bone trough technique...
  45. doi Transesophageal echocardiography utilization in high-volume liver transplantation centers in the United States
    David B Wax
    Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cardiothorac Vasc Anesth 22:811-3. 2008
    Transesophageal echocardiography (TEE) during liver transplantation (LT) has been shown to be helpful in managing fluid therapy, monitoring myocardial function, and identifying intraoperative LT complications...
  46. ncbi Organ donation and transplantation trends in the USA, 2003
    Friedrich K Port
    Scientific Registry of Transplant Recipients University Renal Research and Education Association, Ann Arbor, MI, USA
    Am J Transplant 4:7-12. 2004
  47. ncbi Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study
    K Scott Baker
    University of Minnesota Cancer Center, Blood and Marrow Transplant Program, Department of Internal Medicine, University of Minnesota, Minneapolis, USA
    Blood 104:1898-906. 2004
    ..medical late effects among patients with chronic myeloid leukemia (CML) treated with hematopoietic cell transplantation (HCT)...
  48. ncbi A pilot study in sub-SMAS face transplantation: defining donor compatibility and assessing outcomes in a cadaver model
    Alessio Baccarani
    Division of Plastic, Reconstructive, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Plast Reconstr Surg 119:121-9. 2007
    Face transplantation may become a viable alternative in the treatment of patients with severe acquired facial deformity...
  49. ncbi Directed sibling cord blood banking for transplantation: the 10-year experience in the national blood service in England
    Jon Smythe
    Stem Cells and Immunotherapies Department, National Blood Service, NHS Blood and Transplant, Headington, Oxford, UK
    Stem Cells 25:2087-93. 2007
    Umbilical cord blood (UCB) is an important source of hematopoietic stem cells for transplantation. Although UCB is often collected from unrelated donors, directed umbilical cord blood (DCB) from sibling donors also provides an important ..
  50. doi Pediatric transplantation in the United States, 1997-2006
    J C Magee
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Am J Transplant 8:935-45. 2008
    This article represents the sixth annual review of the current state of pediatric transplantation in the United States from the Scientific Registry of Transplant Recipients (SRTR)...
  51. doi Survival of patients identified as candidates for intestinal transplantation: a 3-year prospective follow-up
    Loris Pironi
    Department of Clinical Medicine, University of Bologna, Italy
    Gastroenterology 135:61-71. 2008
    The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition...
  52. doi Approach to the patient with transplantation-related bone loss
    Peter R Ebeling
    Department of Medicine Royal Melbourne Hospital Western Hospital and Endocrinology, The University of Melbourne, Western Hospital, Gordon Street, Footscray 3011, Victoria, Australia
    J Clin Endocrinol Metab 94:1483-90. 2009
    b>Transplantation is an established therapy for end-stage diseases of the kidney, endocrine pancreas, heart, liver, lung, intestines and for many hematological disorders...
  53. pmc Experimental murine and primate models for dissection of the immunosuppressive potential of photochemotherapy in autoimmune disease and transplantation
    C L Berger
    Department of Dermatology and Pathology, Columbia University, New York, New York 10032
    Yale J Biol Med 62:611-20. 1989
    This paper reviews the results achieved in murine and primate models of autoimmune disease and transplantation. These studies have attempted to clarify the nature and specificity of the response induced by reinfusion of phototreated ..
  54. doi Rituximab treatment for Epstein-Barr virus DNAemia after alternative-donor hematopoietic stem cell transplantation
    Stefania Coppoletta
    Division of Hematology and Bone Marrow Transplant, Ospedale San Martino, Genova, Italy
    Biol Blood Marrow Transplant 17:901-7. 2011
    We report 55 patients undergoing an alternative-donor hematopoietic stem cell transplantation (HSCT) who developed Epstein-Barr virus (EBV) DNAemia, with >1000 EBV copies/10(5) peripheral blood mononuclear cells (PBMCs), and were ..
  55. ncbi Interpreting the proteome and peptidome in transplantation
    Tara K Sigdel
    Department of Pediatrics Nephrology, Stanford University Medical School, Stanford University, Stanford, California 94305, USA
    Adv Clin Chem 47:139-69. 2009
    ..and prognostic biomarkers for different diseases as well as for various clinical phenotypes in organ transplantation that can advance targeted therapy for various forms of graft injury...
  56. ncbi Human herpesvirus 6 and central nervous system disease in hematopoietic cell transplantation
    Danielle M Zerr
    Children s Hospital and Regional Medical Center and the Department of Pediatrics, University of Washington, Seattle, Washington, USA
    J Clin Virol 37:S52-6. 2006
    ..In addition, longitudinal observational studies have established a correlation between systemic HHV-6 reactivation and CNS dysfunction. Further research is needed to define optimal diagnostic, prevention, and treatment strategies...
  57. ncbi Does transplantation produce quality of life benefits? A quantitative analysis of the literature
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Medical Center, Pennsylvania 15213, USA
    Transplantation 64:1261-73. 1997
    ..reports published since the early 1970s, it is frequently asserted that quality of life (QOL) outcomes of transplantation have seldom been investigated and/or that little is known about QOL...
  58. ncbi Role of microcirculation in transplantation
    M D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Microcirculation 7:291-306. 2000
    Microcirculatory derangements in organ transplantation, characterized by capillary perfusion failure and inflammation-associated leukocyte recruitment, are major determinants for the manifestation of graft dysfunction and destruction...
  59. ncbi Articular cartilage transplantation. Current and future limitations and solutions
    D W Hayes
    Department of Podiatric Surgery and Traumatology, Broadlawns Medical Center, Des Moines, Iowa, USA
    Clin Podiatr Med Surg 18:161-76. 2001
    ..Although autologous chondrocyte transplantation of the talus is not yet FDA approved, this technique may provide the surgeons with a cutting-edge method to ..
  60. ncbi Antigen-specific T cells for the treatment of infections after transplantation
    Hermann Einsele
    Medizinische Klinik und Poliklinik, Abteilung II, Eberhard Karls Universitat Tubingen, Germany
    Hematol J 4:10-7. 2003
    ..Although these studies are in the early stages and present considerable technical challenges, the results suggest that cellular immunotherapy will be a fruitful area for investigation in future years...
  61. ncbi Post-transplant infections now exceed acute rejection as cause for hospitalization: a report of the NAPRTCS
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Transplant 4:384-9. 2004
    ..001 for trend by transplant year). We conclude that the causes of hospitalization at all times up to 24 months post-transplant, including the critical early 6 months, have shifted away from AR to PTI...
  62. ncbi Fate of alphaGal +/+ pancreatic islet grafts after transplantation into alphaGal knockout mice
    Abhilash P Chandra
    Centre for Transplant and Renal Research, Westmead Millenium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Xenotransplantation 11:323-31. 2004
    ..The role of these antibodies in rejection of non-vascular xenografts remains controversial. This study investigated the role of anti-alphaGal antibodies in rejection of non-vascularized alphaGal+/+ grafts in alphaGal -/- mice...
  63. ncbi Financial outcomes in transplantation--a provider's perspective
    M M Abecassis
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Transplant 6:1257-63. 2006
    Despite a relatively large body of literature on health-care economics, including the economics of transplantation, there is a paucity of literature on financial outcomes of transplant procedures...
  64. ncbi The potential clinical role of ultrasonic strain and strain rate imaging in diagnosing acute rejection after heart transplantation
    Anna Marciniak
    Department of Cardiology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Echocardiogr 8:213-21. 2007
    ....
  65. pmc Protective effect of carbon monoxide in transplantation
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, E1551 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Cell Mol Med 10:650-71. 2006
    ..agents and improvements in organ preservation methods, surgical techniques, and postoperative care, organ transplantation has become an ultimate therapeutic option for irreversible organ failure...
  66. ncbi Liver transplantation: an update
    R C Verdonk
    Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Neth J Med 65:372-80. 2007
    Liver transplantation has been an accepted treatment for end-stage liver disease since the 1980s. Currently it is a highly successful treatment for this indication...
  67. doi Trends in organ donation and transplantation in the United States, 1997-2006
    F K Port
    Scientific Registry of Transplant Recipients, Arbor Research Collaborative for Health, Ann Arbor, MI, USA
    Am J Transplant 8:911-21. 2008
  68. doi Pre-mortem transplantation optimizing interventions: the legal status of consent
    Jocelyn Downie
    Faculty of Law and Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Anaesth 55:458-69. 2008
    The focus of this paper is on consent issues surrounding pre-mortem transplantation optimizing interventions...
  69. doi The international registry on hand and composite tissue transplantation
    Palmina Petruzzo
    Department of Transplantation, Hopital Edouard Herriot, Lyon, France
    Transplantation 86:487-92. 2008
    ..performing hand transplantations have supplied information to the International Registry on Hand and Composite Tissue Transplantation (IRHCCT). The analysis of all cases with follow-up information up to September 2007 is presented here.
  70. pmc Recipient morbidity after living and deceased donor liver transplantation: findings from the A2ALL Retrospective Cohort Study
    C E Freise
    Department of Surgery, University of California San Francisco, San Francisco, CA, USA
    Am J Transplant 8:2569-79. 2008
    Patients considering living donor liver transplantation (LDLT) need to know the risk and severity of complications compared to deceased donor liver transplantation (DDLT)...
  71. doi Emerging viruses in transplantation: there is more to infection after transplant than CMV and EBV
    Staci A Fischer
    Division of Infectious Diseases, Department of Transplant Services, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA
    Transplantation 86:1327-39. 2008
    ....
  72. ncbi Recurrent and new hepatitis C virus infection after liver transplantation
    J E Everhart
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA
    Hepatology 29:1220-6. 1999
    Chronic infection with the hepatitis C virus (HCV) is the most common reason for liver transplantation. We examined the results of laboratory tests for HCV on a cohort of patients who received a liver transplant between 1990 and 1994 at ..
  73. ncbi Definitions of cytomegalovirus infection and disease in transplant recipients
    Per Ljungman
    Department of Hematology, Huddinge University Hospital, Karolinska Institutet, SE 14186 Stockholm, Sweden
    Clin Infect Dis 34:1094-7. 2002
    ..This study seeks to update the definitions of CMV on the basis of recent developments in diagnostic techniques, as well as to add to these definitions the concept of indirect effects caused by CMV...
  74. pmc Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475
    A E Rosser
    School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    J Neurol Neurosurg Psychiatry 73:678-85. 2002
    ..Neural transplantation is effective in animal models of HD and offers a potential strategy for brain repair in patients...
  75. ncbi Impact of current transplantation practices on the changing epidemiology of infections in transplant recipients
    Nina Singh
    Veterans Affairs Medical Center and University of Pittsburgh, Thomas E Starzl Transplantation Institute, Pittsburgh 15240, USA
    Lancet Infect Dis 3:156-61. 2003
    ....
  76. ncbi Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerations
    Henry E Rice
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Pediatr Surg 39:1607-15. 2004
    Complete DiGeorge syndrome results in the absence of functional T cells. Our program supports the transplantation of allogeneic thymic tissue in infants with DiGeorge syndrome to reconstitute immune function...
  77. ncbi Face transplantation: Part II-an ethical perspective
    Peter A Clark
    Saint Joseph s University, Philadelphia, Pennsylvania, U S A
    Med Sci Monit 11:RA41-7. 2005
    ..Even though the microsurgical skills and anatomical knowledge is well established, face transplantation is more than a matter of technical achievement...
  78. ncbi Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation
    Simon C Robson
    Vascular Biology and Transplantation Centers, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Research North, 99 Brookline Avenue, Boston, MA 02215, USA
    Semin Thromb Hemost 31:217-33. 2005
    b>Transplantation results in exposure of the graft vasculature to warm and cold ischemia, followed by perfusion by circulating blood constituents and obligatory oxidant stress...
  79. ncbi Bacterial infection transmitted by human tissue allograft transplantation
    Ted Eastlund
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA
    Cell Tissue Bank 7:147-66. 2006
    ..There is an increasing need for control of microbial contamination in tissue banks, and sterilization of tissue allografts should be recommended whenever possible...
  80. doi Present status of pancreas transplantation in Japan--donation predominantly from marginal donors and modified surgical technique: report of Japan pancreas transplantation registry
    M Ishibashi
    Department of Urology, Nara Medical University Hospital, Nara, Japan
    Transplant Proc 40:486-90. 2008
    ..The aim of this study was to show the effectiveness of pancreas transplantation (PTx) by analyzing the outcomes even under poor donor conditions...
  81. doi The PIERDUB project: International Project on Education and Research in Donation at University of Barcelona: training university students about donation and transplantation
    M Manyalich
    Departament de Cirurgia i Especialitats Quirúrgiques, Universitat de Barcelona, Barcelona, Spain
    Transplant Proc 42:117-20. 2010
    Donation and transplantation is an accepted therapeutic option when organ failure or tissue replacements are needed to save or improve the quality of life...
  82. pmc HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation
    Ann Woolfrey
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 17:885-92. 2011
    The association between HLA matching and outcome in unrelated-donor peripheral blood stem cell (PBSC) transplantation has not yet been established...
  83. pmc Immunotherapeutic options for Epstein-Barr virus-associated lymphoproliferative disease following transplantation
    Donald R Shaffer
    Center for Cell and Gene Therapy, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
    Immunotherapy 2:663-71. 2010
    Epstein-Barr virus-associated lymphoproliferative diseases (EBV-LPD) after hematopoietic stem cell transplantation or solid-organ transplantation remain a serious and potentially life-threatening complication...
  84. pmc Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study
    Katharina Fleischhauer
    Unit of Molecular and Functional Immunogenetics, Division of Regenerative Medicine, Stem Cells and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico H San Raffaele, Milan, Italy
    Lancet Oncol 13:366-74. 2012
    The risks after unrelated-donor haemopoietic-cell transplantation with matched HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 alleles between donor and recipient (10/10 matched) can be decreased by selection of unrelated donors who also match ..
  85. pmc Disseminated Trichosporon mycotoxinivorans, Aspergillus fumigatus, and Scedosporium apiospermum coinfection after lung and liver transplantation in a cystic fibrosis patient
    Sandrine Hirschi
    Service de Pneumologie, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    J Clin Microbiol 50:4168-70. 2012
    ..We report the first case of a disseminated fatal infection with T. mycotoxinivorans associated with invasive Aspergillus fumigatus and Scedosporium apiospermum infection after lung and liver transplantation in a cystic fibrosis patient.
  86. ncbi Organ donation and transplantation within the Zulu culture
    B R Bhengu
    School of Nursing, University of KwaZulu Natal
    Curationis 27:24-33. 2004
    Greater knowledge and technological advancement in the field of transplantation has increased the demand for organ donation beyond the supply of organs, especially among the black communities...
  87. ncbi Human herpesvirus-6 and -7 in transplantation
    D H Dockrell
    Division of Molecular and Genetic Medicine, University of Sheffield Medical School, F-floor Medical Microbiology, Beechill Road, Sheffield S10 2RX, UK
    Rev Med Virol 11:23-36. 2001
    ..The immunosuppression secondary to organ or bone marrow transplantation together with posttransplantation management may favour viral replication and reactivation...
  88. ncbi Psychiatric morbidity in patients undergoing heart, heart and lung, or lung transplantation
    A Trumper
    School of Psychiatry and Behavioural Sciences, Withington Hospital, University of Manchester, Nell Lane, West Didsbury, M20 8LR, Manchester, UK
    J Psychosom Res 50:103-5. 2001
    OBJECTIVES: To determine the rate of psychiatric disorder in people undergoing heart and/or lung transplantation; to identify the associations of psychiatric disorder in this group...
  89. ncbi Transplantation of the human uterus
    W Fageeh
    Multiorgan Transplant Unit, King Fahad Hospital and Research Center, Jeddah, Saudi Arabia w_
    Int J Gynaecol Obstet 76:245-51. 2002
    Human uterine transplantation was performed on 6 April 2000 on a 26-year-old female who lost her uterus 6 years earlier due to post-partum hemorrhage...
  90. ncbi A position statement in support of hand transplantation
    Warren C Breidenbach
    Christine M Kleinert Institute of Hand and Microsurgery, Jewish Hospital, Louisville, KY 40202, USA
    J Hand Surg Am 27:760-70. 2002
    The scientific basis for human trials of hand transplantation was both experimental and clinical. Prolonged survival of limb transplants was achieved in small and large animals by using novel immunosuppressive drugs...
  91. ncbi Cadaver organ donation and transplantation-an Indian perspective
    S Shroff
    Sri Ramachandra Medical College Research Institute, Chennai, India
    Transplant Proc 35:15-7. 2003
  92. ncbi Avoiding steroids in solid organ transplantation
    Jan P Lerut
    Department of Digestive Surgery, Cliniques Universitaires St Luc 1400, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium
    Transpl Int 16:213-24. 2003
    The excellent results obtained today in solid-organ transplantation allow the envisaging of an improvement in long-term quality of life with a functioning graft...
  93. pmc Presumed consent for transplantation: a dead issue after Alder Hey?
    V English
    Department of Medical Ethics, British Medical Association, Tavistock Square, London WC1H 9JP, UK
    J Med Ethics 29:147-52. 2003
    ..than therapy, concern has been expressed that public mistrust could also adversely affect organ donation for transplantation. At the same time, however, the British Medical Association (BMA) continues to call for a shift to a system ..
  94. ncbi Liver transplantation with hepatitis C virus-infected graft: interaction between donor and recipient viral strains
    Xiaofeng Fan
    Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO, USA
    Hepatology 38:25-33. 2003
    ..small animal models supporting efficient HCV replication, we explored these issues in the setting of liver transplantation where both recipient and donor were infected with different HCV strains and therefore represent a distinct ..
  95. ncbi Lymphomas after solid organ transplantation: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 4:222-30. 2004
    ..This study highlights the continuing risk for lymphoma with time post-transplantation, the contribution of immunosuppression to increased risk, and continuing poor outcomes in patients with post-..
  96. ncbi New-Onset Diabetes After Transplantation 2003 International Consensus Guidelines: an endocrinologist's view
    Jaime A Davidson
    Endocrine and Diabetes Associates of Texas, Dallas, Texas 75230, USA
    Diabetes Care 27:805-12. 2004
  97. ncbi Factors influencing the willingness to donate body parts for transplantation
    Roger Bennett
    Department of Business and Service Sector Management, London Metropolitan University, 84 Moorgate, London, EC2M 6SQ, United Kingdom
    J Health Soc Policy 18:61-85. 2004
    ..Members of the sample already possessing donor cards were more knowledgeable about the issue of organ transplantation than others, were less squeamish, and had relatives who favoured organ donation...
  98. ncbi "Don't know enough about it!": awareness and attitudes toward organ donation and transplantation among the black Caribbean and black African population in Lambeth, Southwark, and Lewisham, United Kingdom
    Cynthia Davis
    South Thames Transplant Coordination Service, King s College Hospital, London, England
    Transplantation 78:420-5. 2004
    ..The situation is clear: There is an urgent need to address the number of black African and black Caribbean patients requiring a kidney transplant, otherwise the human and economic costs will be high...
  99. ncbi Osteochondritis dissecans of the talus treated by the transplantation of tissue-engineered cartilage
    Muhammad Agung
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Arthroscopy 20:1075-80. 2004
    ..In this study, we reported on a patient with osteochondritis dissecans of the talar dome, successfully treated by transplantation of tissue-engineered cartilage made ex vivo using atelocollagen gel and low tibial osteotomy.
  100. ncbi Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome
    Shahid Husain
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Clin Infect Dis 40:89-99. 2005
    ..Unique characteristics, impact of therapy with antifungal agents, and outcome of infections with Scedosporium species were assessed in transplant recipients...
  101. ncbi Age and immune response in organ transplantation
    Paulo N A Martins
    Department of General and Transplantation Surgery, Charite Virchow Clinic, Humboldt University, Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Transplantation 79:127-32. 2005
    ..target changes associated with the senescence process seem to be promising therapeutic strategies to improve transplantation outcome...

Research Grants80

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..The Natural History of Ocular Graft-Versus Host Disease Number: 11-EI-0173 Summary: Background: - Stem cell transplantation (SCT) is used to treat some kinds of cancer, blood cell disorders, and immune disorders...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..The Natural History of Ocular Graft-Versus Host Disease Number: 11-EI-0173 Summary: Background: - Stem cell transplantation (SCT) is used to treat some kinds of cancer, blood cell disorders, and immune disorders...
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..In addition, we have been prospectively evaluating new approaches to stem cell transplantation in order to decrease morbidity and increase access for patients without allogeneic matches64-67...
  4. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..consequences in various clinical settings such as thrombolytic therapy, cardiopulmonary bypass, organ transplantation, and acute percutaneous coronary angioplasty...
  5. Yasmin Wadia; Fiscal Year: 2014
    ..of solid visceral organs, such as the liver spleen, pancreas and kidney, involved in trauma, cancer and transplantation in presence of coagulopathies or anticoagulation...
  6. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..with alpha-1-antitrypsin (A1AT) deficiency develop liver fibrosis/cirrhosis many times resulting in liver transplantation, the transgenic mouse model carrying mutant human genes shows an extremely mild phenotype...
  7. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..others have shown that NCSCs isolated from the fetal rodent gut can engraft and form enteric neurons after transplantation into the aganglionic region of the gut from rodent models of Hirschsprung disease ADDIN EN.CITE ADDIN EN.CITE...
  8. Sogol Mostoufi-Moab; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is an established treatment for benign and malignant hemato- logic diseases in children...
  9. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..of numerous autoimmune and inflammatory diseases, and as anti-rejection agents in bone marrow and solid organ transplantation. The long term effects of these agents on the skeleton are unknown however, our preliminary studies suggest ..
  10. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..especially difficult clinical problems because the disease recurs in about 30% of such patients after renal transplantation and leads to transplant loss in many patients...
  11. Paolo Fanti; Fiscal Year: 2014
    ..kidney disease, with spilling of protein in the urine and, eventually, with the need for dialysis or kidney transplantation. In most cases, the available treatments cannot stop the progression of diabetic kidney disease and the ..
  12. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..b>Transplantation of PRDM16 expressing fibroblasts...
  13. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..only progressive, in many cases to end stage kidney disease requiring artificial kidney treatments or kidney transplantation, but also contributes greatly to the very high incidence of heart and circulatory disease...
  14. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..R-503, intended for the prevention of lung ischemia-reperfusion injury (LIRI) associated with orthotopic lung transplantation. LIRI results from an acute reperfusion-induced alteration in the synthesis of the free radical superoxide ..
  15. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
    ..pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation, but effective therapeutic strategies are not currently available...
  16. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
  17. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..According to the Department of Health and Human Services, more than 25,000 patients undergo solid organ transplantation every year in the U.S. Approximately 100,000 patients are currently waiting for compatible transplants...
  18. Norma S Kenyon; Fiscal Year: 2015
    ..islet allograft outcome and to assess the efficacy of third party activated MSC (aMSC) in allogeneic renal transplantation. Aim 2...
  19. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..Aim 1 will utilize lung and pulmonary artery tissue and serum procured at the time of organ transplantation in patients with IPAH, disease-specific controls with PAH due to other causes, or patients without PAH to ..
  20. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    Allogeneic stem cell transplantation (allo-SCT) is potentially curative therapy for a patients suffering from leukemia, lymphoma and multiple myeloma...
  21. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..yet these patients are often ineligible for life-saving high dose chemotherapy and autologous stem cell transplantation. It results from the deposition of misfolded amyloid proteins derived from immunoglobulin light chains and ..
  22. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..Beyond cerebral IRI, any successful therapy to reduce IRI would have a profound impact on organ transplantation, myocardial damage due to CPB, and the natural history and treatment for MI and stroke...
  23. Thalachallour Mohanakumar; Fiscal Year: 2015
    ..Syndrome (BOS), is the most significant long term cause of morbidity and mortality following human lung transplantation (LTx)...
  24. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..a novel cytoprotective agent (R-801) for the prevention of ischemia-reperfusion injury (IRI) following lung transplantation (LTX)...
  25. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..Stem cell transplantation is the treatment of choice for eligible patients with bone marrow failure...
  26. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..failure caused by complex trauma including blast injury, septic shock, and graft failure after liver transplantation often leading to death of the patient...
  27. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The advent of artificial tissues, cord blood therapies, cell transplantation procedures, and the desire to bank germ cells have driven the need to establish a means to reliably store biological ..
  28. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..Stem cell transplantation is the treatment of choice for eligible patients with bone marrow failure...
  29. JAMES M COGHILL; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is a therapeutic procedure that is used to treat advanced hematologic malignancies or other blood disorders...
  30. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..opportunistic infections in immunocompromised patients, such as those undergoing chemotherapy, organ transplantation, and those with immunodeficiencies and HIV...
  31. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..between eicosanoids is relevant in directing enhanced marrow recovery after injury in zebrafish and murine transplantation models and in assays with human cord blood...
  32. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..If successful, such beneficial outcomes may improve the health of veterans with acute ischemic syndromes during cardiac transplantation, coronary bypass surgery, and other acquired cardiac conditions.
  33. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
    ..indicate that it may be feasible to create a conditional inbred SCID Ada KO rat line suitable for human cell transplantation studies...
  34. Phillip Darwin Bell; Fiscal Year: 2016
    ..is a devastating disease that usually results in renal failure with treatment options limited to dialysi and transplantation. There are also cardiovascular effects including hypertension and stroke...
  35. LIVER PRESERVATION FOR TRANSPLANTATION
    John J Lemasters; Fiscal Year: 2012
    ..During the previous period of support, we showed that JNK activation occurs after liver transplantation and that pharmacological inhibition of JNK decreases graft injury and improves graft survival...
  36. Kenneth J Gustafson; Fiscal Year: 2015
    ..complications, such as incontinence, urinary tract infection, renal damage and consequent renal dialysis or transplantation which can lead to recurrent and costly hospitalization...
  37. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..Graft-versus-host disease (GvHD) is the major limiting factor to the widespread use of allogeneic stem cell transplantation. GvHD is due to the recognition by donor T cells of minor or major MHC disparities found on antigen-..
  38. Enrico M Novelli; Fiscal Year: 2016
    ..Extensive preliminary data using chimera cross transplantation systems confirm that CD47 is critical in the development of PH in the transgenic sickle cell mouse...
  39. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    ..disorders and statistics, and through mentored research training in primary tissue culture, cell transplantation, behavioral analysis of transgenic mice, gene expression microarray experiments using the translating ..
  40. Patrick Cahan; Fiscal Year: 2016
    ..This is accomplished by transplantation experiments, where donor cells are injected intravenously into lethally irradiated, immunodeficient recipient ..
  41. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..Hematopoietic stem cell transplantation can reduce some manifestations, but has a 15% mortality rate, costs $130,000, and requires a compatible donor...
  42. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..It is also tested by showing that the hemotopoietic stem cell-based marrow transplantation with WT- EphA4, but not the mutant lacking the key phosphotyrosine residues, would reverse the osteoporotic ..
  43. SAMUEL WHEELER FRENCH; Fiscal Year: 2015
    ..C virus (HCV) infection has a worldwide prevalence of 3% and is the main entity responsible for liver transplantation in developed countries for treatment of cirrhosis...
  44. KATHERINE JULIA KELLY; Fiscal Year: 2014
    ..Finally, we will evaluate tubular cell transplantation as an innovative therapy for renal failure...
  45. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..Organ transplantation addresses some of these needs, but the scarcity of donors and the risk of immune suppression pose major ..
  46. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..They insidiously lead to end- stage kidney disease (ESKD) requiring dialysis or kidney transplantation for survival. 20 million individuals in the U.S. suffer from CKD with a treatment cost of >$20 billion/yr...
  47. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
    ..Defining which microbes and how they contribute to these diseases will lead to new approaches to diagnosis, prevention and therapy and make a major contribution to improved public health. ..
  48. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..have demonstrated that bone marrow contains cells that can engraft and become competent osteoblasts after transplantation. Clinical trials using bone marrow stem cells in a small number of children with severe forms of OI have ..
  49. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    Abstract. Allogeneic transplantation, the standard-of-care for a variety of inherited disorders, is limited by a shortage of compatible donors, low numbers of engrafting hematopoietic stem cells (HSC), the toxicity of necessary ..
  50. Development of a Pediatric Mylelodysplastic Syndrome Patient Registry
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..little is known about the initiating events leading to pMDS, and thus no targeted therapies exist;bone marrow transplantation is the only therapeutic option for these patients...
  51. KATHERINE YUDEH KING; Fiscal Year: 2014
    ..This research will have immediate application for patients recovering from bone marrow transplantation. Furthermore, this work will lead to insight and potential interventions for myelosuppression as a result of ..
  52. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..protocol that is clinically applicable using fully differentiated stem cells in bioartifical organ/cell transplantation. PUBLIC HEALTH RELEVANCE: This pilot study may lead to a new strategy that uses thermal treatments to enhance ..
  53. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    ..IRP) injury is an important clinical problem, which determines morbidity and mortality after liver transplantation, liver surgery and hemorrhagic or septic shock. IRP injury is an even bigger issue in steatotic livers...
  54. Mario Strazzabosco; Fiscal Year: 2016
    ..disease (CFLD) negatively impacts the quality of life and survival of CF patients, and may require liver transplantation, however, the pathogenesis of this condition is not well understood...
  55. SATB1-dependent epigenetic regulation of leukemia initiating cells
    Britta Will; Fiscal Year: 2011
    ..gene expression regulation in HSC and LIC will be characterized using in vivo models, such as stem cell transplantation assays...
  56. Jakub Tolar; Fiscal Year: 2016
    ..concerns with allogeneic transplants, such as toxicity to chemotherapy required for conditioning before transplantation, and susceptibility to infections due to the necessity for immunosuppressive therapy to prevent rejection of ..
  57. Elizabeth R Jacobs; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Experts in lung transplantation agree that ischemia is a recognized risk factor for all postlung transplant problems...
  58. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..When progression of CKD to end-stage renal disease (ESRD) cannot be prevented, then either dialysis or kidney transplantation are required to prevent immediate mortality...
  59. Bachir Taouli; Fiscal Year: 2014
    ..cirrhosis, which may eventually lead to hepatocellular carcinoma and end-stage liver disease requiring liver transplantation. This disease is/will be the source of enormous health care costs and morbidity/mortality...
  60. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ..Currently, the best option for completely restoring cardiac function after a large MI is heart transplantation. However, it is limited by donor availability and transplant rejection...
  61. Oliver W Press; Fiscal Year: 2014
    ..the majority of afflicted patients despite treatment with combination chemotherapy and hematopoietic cell transplantation (HCT)...
  62. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..frequently colonized or at times mildly infected and whether this should promote or discourage their use for transplantation remains a question...
  63. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..antivirals, are largely ineffective in treating the underlying fibrosis, and in the majority of cases, liver transplantation is the only effective cure...
  64. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is a successful treatment option for many patients with severe hematologic diseases...
  65. New Solutions to Improve Islet Recovery after Machine Preservation of Pancreas
    Michael Taylor; Fiscal Year: 2009
    b>Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the "Edmonton protocol"...
  66. Targeting the leukemia microenvironment by CXCR4 inhibition in stem cell transpla
    Marina Y Konopleva; Fiscal Year: 2010
    ..Allogeneic stem cell transplantation is an effective treatment for AML in first remission, with approximately 60% achieving long-term progression-..
  67. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lung transplantation is a life-saving option for selected patients with end-stage lung disease...
  68. NF-kB Inhibition of Lung Ischemia Repurfusion Injury
    Patrick Flood; Fiscal Year: 2009
    ..IRI is also a major problem in organ transplantation, because IRI is the major cause of primary graft failure and organ dysfunction after transplant...
  69. OPTIMIZING SPERMATOGONIAL TRANSPLANTATION FOR FERTILITY PRESERVATION
    Gunapala Shetty; Fiscal Year: 2010
    ..In such cases cryopreservation of spermatogonia and autologous transplantation is the only a potential method for restoring spermatogenesis and possibly rescuing fertility...
  70. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..of the HLA antibody and to determine the clinical relevance of class I and II signaling pathways in cardiac transplantation. Patient samples to be used in the proposed research will be obtained from the "CTOT-05 Observational Study ..
  71. Pig to Non-Human Primate Islet Xenografts
    Bernhard Hering; Fiscal Year: 2009
    DESCRIPTION: Recent clinical reports of allogeneic human islet transplantation provide proof of principle that cell-based diabetes therapy can reverse the course of diabetes mellitus...
  72. MECHANISMS OF ALLOGENEIC STEM CELL EDUCATION IN SCID
    Rebecca H Buckley; Fiscal Year: 2010
    ..3) reducing the incidence of autoimmunity, and 4) contributing to their overall successful immune transplantation may be beneficial to these chimeras by 1) increasing their resistance to infection, 2) whether the decline in ..
  73. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
    ..Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and significantly improving quality of ..
  74. A Novel Method to Isolate Islet Cells
    JERRY KNOBELOCH; Fiscal Year: 2007
    ..to dissociate tissue from donor pancreas using ultrasound for the recovery of pancreatic islet cells for transplantation, and 2) marked improvement in yields and viability of islets recovered using this approach as compared to the ..