photochemotherapy

Summary

Summary: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.

Top Publications

  1. pmc Photodynamic therapy of cancer: an update
    Patrizia Agostinis
    Department of Molecular Cell Biology, Cell Death Research and Therapy Laboratory, Catholic University of Leuven, Belgium
    CA Cancer J Clin 61:250-81. 2011
  2. ncbi Photodynamic therapy for cancer
    Dennis E J G J Dolmans
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Cancer 3:380-7. 2003
  3. ncbi Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results
    Frederik Raiskup-Wolf
    Department of Ophthalmology, C G Carus University Hospital, Dresden, Germany
    J Cataract Refract Surg 34:796-801. 2008
  4. ncbi Safety of UVA-riboflavin cross-linking of the cornea
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum Dresden, Dresden, Germany
    Cornea 26:385-9. 2007
  5. ncbi Photophysics and photochemistry of photodynamic therapy: fundamental aspects
    K Plaetzer
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria
    Lasers Med Sci 24:259-68. 2009
  6. pmc Photodynamic therapy and anti-tumour immunity
    Ana P Castano
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Rev Cancer 6:535-45. 2006
  7. pmc Photodynamic therapy: a new antimicrobial approach to infectious disease?
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Photochem Photobiol Sci 3:436-50. 2004
  8. ncbi Pegaptanib for neovascular age-related macular degeneration
    Evangelos S Gragoudas
    Retina Service, Massachusetts Eye and Ear Infirmary and Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    N Engl J Med 351:2805-16. 2004
  9. ncbi Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo
    Boseung Jang
    Molecular Imaging and Therapy Branch, National Cancer Center, 111 Jungbalsan ro, Ilsandong gu, Goyang, Gyeonggi do 410 769, South Korea
    ACS Nano 5:1086-94. 2011
  10. ncbi Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study
    Aldo Caporossi
    Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    Am J Ophthalmol 149:585-93. 2010

Detail Information

Publications340 found, 100 shown here

  1. pmc Photodynamic therapy of cancer: an update
    Patrizia Agostinis
    Department of Molecular Cell Biology, Cell Death Research and Therapy Laboratory, Catholic University of Leuven, Belgium
    CA Cancer J Clin 61:250-81. 2011
    ..With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment...
  2. ncbi Photodynamic therapy for cancer
    Dennis E J G J Dolmans
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Cancer 3:380-7. 2003
    ..How does PDT work, and how can it be used to treat cancer and other diseases?..
  3. ncbi Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results
    Frederik Raiskup-Wolf
    Department of Ophthalmology, C G Carus University Hospital, Dresden, Germany
    J Cataract Refract Surg 34:796-801. 2008
    ..To prove the long-term dampening effect of riboflavin- and ultraviolet-A-induced collagen crosslinking on progressive keratoconus...
  4. ncbi Safety of UVA-riboflavin cross-linking of the cornea
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum Dresden, Dresden, Germany
    Cornea 26:385-9. 2007
    ..To study potential damage to ocular tissue during corneal collagen cross-linking (X-linking) by means of the riboflavin/UVA (370 nm) approach...
  5. ncbi Photophysics and photochemistry of photodynamic therapy: fundamental aspects
    K Plaetzer
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria
    Lasers Med Sci 24:259-68. 2009
    ..e. tumor-centered approach with a focus on the actual clinical requirements of the respective tumor type...
  6. pmc Photodynamic therapy and anti-tumour immunity
    Ana P Castano
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Rev Cancer 6:535-45. 2006
    ....
  7. pmc Photodynamic therapy: a new antimicrobial approach to infectious disease?
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Photochem Photobiol Sci 3:436-50. 2004
    ....
  8. ncbi Pegaptanib for neovascular age-related macular degeneration
    Evangelos S Gragoudas
    Retina Service, Massachusetts Eye and Ear Infirmary and Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    N Engl J Med 351:2805-16. 2004
    ..Pegaptanib, an anti-vascular endothelial growth factor therapy, was evaluated in the treatment of neovascular age-related macular degeneration...
  9. ncbi Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo
    Boseung Jang
    Molecular Imaging and Therapy Branch, National Cancer Center, 111 Jungbalsan ro, Ilsandong gu, Goyang, Gyeonggi do 410 769, South Korea
    ACS Nano 5:1086-94. 2011
    ..This novel multifunctional nanomedicine may be useful for near-infrared fluorescence imaging and PTT/PDT in various cancers...
  10. ncbi Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study
    Aldo Caporossi
    Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    Am J Ophthalmol 149:585-93. 2010
    ..To report the long-term results of 44 keratoconic eyes treated by combined riboflavin ultraviolet A collagen cross-linking in the first Italian open, nonrandomized phase II clinical trial, the Siena Eye Cross Study...
  11. ncbi Photodynamic inactivation of multi-resistant bacteria (PIB) - a new approach to treat superficial infections in the 21st century
    Tim Maisch
    Department of Dermatology, University of Regensburg, Germany
    J Dtsch Dermatol Ges 9:360-6. 2011
    ..In this review the physical-chemical and biological basics of photo-dynamic inactivation of bacteria (PIB) will be discussed as well as the possible dermatological indications...
  12. ncbi Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy
    Masahiro Ishizuka
    SBI ALApromo Co, LTD Roppongi 1 6 1, Minato ku, Tokyo 106 6019, Japan
    Int Immunopharmacol 11:358-65. 2011
    ..In this review, the biological significance of heme metabolites, the mechanism of PpIX accumulation in tumor cells, and the therapeutic potential of ALA-induced PDT alone and combined with hyperthermia and immunotherapy are discussed...
  13. ncbi Comparative characterization of the efficiency and cellular pharmacokinetics of Foscan- and Foslip-based photodynamic treatment in human biliary tract cancer cell lines
    Tobias Kiesslich
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria
    Photochem Photobiol Sci 6:619-27. 2007
    ....
  14. pmc Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules
    Makoto Mitsunaga
    Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 17:1685-91. 2011
    ..Target-selective PIT enables treatment of cancer based on mAb binding to the cell membrane...
  15. ncbi Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
    Esther Buytaert
    Department of Molecular and Cell Biology, Faculty of Medicine, Catholic University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven Belgium
    Biochim Biophys Acta 1776:86-107. 2007
    ..This review highlights recent developments aimed at deciphering the molecular interplay between cell death pathways as well as their possible therapeutic exploitation in photosensitized cells...
  16. ncbi Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study
    Aldo Caporossi
    Department of Ophthalmological and Neurosurgical Sciences, Siena University, Siena, Italy
    J Cataract Refract Surg 32:837-45. 2006
    ..To assess the effectiveness of riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen in reducing progression of keratoconus and in improving visual acuity in patients with progressive keratoconus...
  17. pmc Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells
    Cy Hyun Kim
    National Research and Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Int J Nanomedicine 6:1357-63. 2011
    ..Furthermore, an increased amount of PpIX in HuCC-T1 cells induced increased production of ROS by irradiation, resulting in increased phototoxicity...
  18. ncbi A systematic review of photodynamic therapy in the treatment of pre-cancerous skin conditions, Barrett's oesophagus and cancers of the biliary tract, brain, head and neck, lung, oesophagus and skin
    D Fayter
    Centre for Reviews and Dissemination CRD, University of York, York, UK
    Health Technol Assess 14:1-288. 2010
    ..PDT is used either as a primary treatment or as an adjunctive treatment. It is fairly well accepted in clinical practice for some types of skin cancer but has yet to be fully explored as a treatment for other forms of cancer...
  19. ncbi Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results
    Peter K Kaiser
    Cole Eye Institute, Cleveland, OH 44195, USA
    Am J Ophthalmol 144:850-857. 2007
    ....
  20. ncbi The present and future role of photodynamic therapy in cancer treatment
    Stanley B Brown
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Microbiology, University of Leeds, UK
    Lancet Oncol 5:497-508. 2004
    ..Here, we review current use of PDT in oncology and look at its future potential as more selective photosensitising drugs become available...
  21. ncbi Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration
    Takashi Tsuchihashi
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 118:93-100. 2011
    ....
  22. ncbi Nanoparticles in photodynamic therapy: an emerging paradigm
    Dev Kumar Chatterjee
    Division of Bioengineering, National University of Singapore, 117574, Singapore
    Adv Drug Deliv Rev 60:1627-37. 2008
    ..Although several challenges remain before they can be adopted for clinical use, these active or second-generation PDT nanoparticles probably offer the best hope for extending the reach of PDT to regions deep in the body...
  23. ncbi Photodynamic antimicrobial chemotherapy (PACT)
    M Wainwright
    Department of Chemistry, University of Central Lancashire, Preston, UK
    J Antimicrob Chemother 42:13-28. 1998
    ..PACT is proposed as a potential, low-cost approach to the treatment of locally occurring infection...
  24. ncbi The role of apoptosis in response to photodynamic therapy: what, where, why, and how
    Nancy L Oleinick
    Department of Radiation Oncology and the CWRU UHC Ireland Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Photochem Photobiol Sci 1:1-21. 2002
    ..necrotic pathway and for producing tumor ablation in conjunction with tissue-level mechanisms operating in vivo...
  25. ncbi Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas
    Farhad Hafezi
    Institute for Refractive and Ophthalmic Surgery, Zurich, Switzerland
    J Cataract Refract Surg 35:621-4. 2009
    ..Preoperative swelling of the cornea safely broadens the spectrum of CXL indications to thin corneas that would otherwise not be eligible for treatment...
  26. ncbi A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results
    Christine Wittig-Silva
    Centre for Eye Research Australia, East Melbourne, Australia
    J Refract Surg 24:S720-5. 2008
    ..This prospective, randomized, controlled trial aims to provide evidence in relation to the efficacy and safety of corneal collagen cross-linking (CXL) in the management of progressive keratoconus...
  27. ncbi Intracellular photodynamic therapy with photosensitizer-nanoparticle conjugates: cancer therapy using a 'Trojan horse'
    Martina E Wieder
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK NR4 7TJ
    Photochem Photobiol Sci 5:727-34. 2006
    ..Our results suggest that gold nanoparticle conjugates are an excellent vehicle for the delivery of surface bound hydrophobic photosensitizers for efficacious photodynamic therapy of cultured tumour cells...
  28. ncbi DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown
    Abhishek D Garg
    Department of Molecular Cell Biology, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium
    Photochem Photobiol Sci 10:670-80. 2011
    ..We also discuss how certain PDT paradigms may yield therapies that optimally stimulate the immune system and lead to the discovery of new DAMPs...
  29. ncbi State of the art in the delivery of photosensitizers for photodynamic therapy
    Yvette Niamien Konan
    University of Geneva, School of Pharmacy, CH 1211 Geneva 4, Switzerland
    J Photochem Photobiol B 66:89-106. 2002
    ..Specific targeting can also be achieved by binding of monoclonal antibodies or specific tumour-seeking molecules to PS or by the coating of PS loaded carriers...
  30. ncbi Crosslinking treatment of progressive keratoconus: new hope
    Gregor Wollensak
    Department of Ophthalmology, Universitatsklinikum CGC, Dresden, Germany
    Curr Opin Ophthalmol 17:356-60. 2006
    ..Biomechanical measurements have shown an impressive increase in corneal rigidity of 328.9% in human corneas after crosslinking...
  31. pmc In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model
    N Komerik
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, United Kingdom
    Antimicrob Agents Chemother 47:932-40. 2003
    ..gingivalis is possible in vivo and that this results in decreased bone loss. These findings suggest that photodynamic therapy may be useful as an alternative approach for the antimicrobial treatment of periodontitis...
  32. ncbi Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts
    Hans Peter Iseli
    Institute of Refractive and Ophthalmic Surgery, Zurich, Switzerland
    Cornea 27:590-4. 2008
    ..To evaluate the efficacy of ultraviolet-corneal cross-linking (CXL) for treating infectious melting keratitis...
  33. pmc Role of cytokines in photodynamic therapy-induced local and systemic inflammation
    S O Gollnick
    PDT Center, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14263, USA
    Br J Cancer 88:1772-9. 2003
    ..They also lay the mechanistic groundwork for further ongoing studies that attempt to optimise PDT through the modulation of the critical inflammatory mediators...
  34. ncbi Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation
    Xinmin Ding
    Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, China
    Cancer Lett 216:43-54. 2004
    ..These results demonstrated that ROS generated in HeLa cells by HMME-PDT-induced apoptosis may be through [Ca2+]i elevation which mediates Cyto C release and Caspase-3 activition and initiates the subsequent late stages of apoptosis...
  35. ncbi Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy
    Aisling E O'Connor
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Photochem Photobiol 85:1053-74. 2009
    ..The aim of this review is to provide an insight into PDT photosensitizers clinically approved for application in oncology, as well as those which show significant potential in ongoing preclinical studies...
  36. ncbi Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity
    Abhishek D Garg
    Department of Molecular Cell Biology, Catholic University of Leuven, Belgium
    Apoptosis 15:1050-71. 2010
    ..The ability of PDT to expose/release DAMPs and the future perspectives of this paradigm have also been discussed...
  37. ncbi The physics, biophysics and technology of photodynamic therapy
    Brian C Wilson
    Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Phys Med Biol 53:R61-109. 2008
    ..The final section of the review introduces some new frontiers of research including low dose rate (metronomic) PDT, two-photon PDT, activatable PDT molecular beacons and nanoparticle-based PDT...
  38. ncbi Polypoidal choroidal vasculopathy
    Antonio P Ciardella
    The LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021, USA
    Surv Ophthalmol 49:25-37. 2004
    ....
  39. ncbi An update on photodynamic therapy applications
    Thomas J Dougherty
    Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Clin Laser Med Surg 20:3-7. 2002
    ..This review updates the current and future role of PDT in cancer and other diseases...
  40. ncbi Current clinical and preclinical photosensitizers for use in photodynamic therapy
    Michael R Detty
    Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260 3000, USA
    J Med Chem 47:3897-915. 2004
  41. ncbi Collagen cross-linking in early keratoconus with riboflavin in a femtosecond laser-created pocket: initial clinical results
    Anastasios John Kanellopoulos
    Laservision gr Institute, Athens, Greece
    J Refract Surg 25:1034-7. 2009
    ..To evaluate the safety and efficacy of a novel femtosecond laser-assisted technique for intrastromal administration of riboflavin and higher fluence ultraviolet a (UVA) light in collagen cross-linking (CXL) for keratoconus...
  42. ncbi Nanoparticles as vehicles for delivery of photodynamic therapy agents
    Denise Bechet
    Centre de Recherche en Automatique de Nancy, Nancy University, Vandoeuvre les Nancy, France
    Trends Biotechnol 26:612-21. 2008
    ..Finally, we summarize exciting new results concerning the improvement of the photophysical properties of nanoparticles by means of biphotonic absorption and upconversion...
  43. ncbi Photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a 30-month multicenter study in Hyogo, Japan
    Shigeru Honda
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, and Department of Ophthalmology, Kobe City General Hospital, Kobe, Japan
    Jpn J Ophthalmol 53:593-7. 2009
    ..To evaluate the long-term effects of photodynamic therapy (PDT) on different phenotypes of age-related macular degeneration (AMD): typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV)...
  44. ncbi A new strategy to destroy antibiotic resistant microorganisms: antimicrobial photodynamic treatment
    Tim Maisch
    Antimicrobial PDT, Clinic and Polyclinic for Dermatology, Regensburg University Hospital, Germany, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Mini Rev Med Chem 9:974-83. 2009
    ....
  45. pmc Photodynamic therapy enhancement of antitumor immunity is regulated by neutrophils
    Philaretos C Kousis
    Department of Cell Stress Biology and the Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Res 67:10501-10. 2007
    ..Immune-enhancing PDT regimens may then be combined with treatments that result in optimal ablation of primary tumors, thus inhibiting growth of primary tumor and controlling disseminated disease...
  46. ncbi The history of photodetection and photodynamic therapy
    R Ackroyd
    Section of Surgical and Anesthetic Sciences, Division of Clinical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Photochem Photobiol 74:656-69. 2001
    ..as Finsen, Raab and Von Tappeiner, the combination of light and drug administration led to the emergence of photochemotherapy as a therapeutic tool...
  47. ncbi Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance in vitro
    Ayman Khdair
    Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA
    Eur J Pharm Biopharm 71:214-22. 2009
    ..In conclusion, nanoparticle-mediated combination chemotherapy and PDT using doxorubicin and methylene blue was able to overcome resistance mechanisms and resulted in improved cytotoxicity in drug-resistant tumor cells...
  48. ncbi One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:141-6. 2008
    ....
  49. ncbi Complication and failure rates after corneal crosslinking
    Tobias Koller
    From Institut für Refraktive und Ophthalmo Chirurgie, Zurich, Switzerland
    J Cataract Refract Surg 35:1358-62. 2009
    ..To evaluate the complication rate of corneal crosslinking (CXL) for primary keratectasia and to develop recommendations for avoiding complications...
  50. ncbi A spectroscopic study of the photobleaching of protoporphyrin IX in solution
    M B Ericson
    Department of Experimental Physics, School of Physics and Engineering Physics, Chalmers University of Technology, Goteborg University, SE 412 96 Goteborg, Sweden
    Lasers Med Sci 18:56-62. 2003
    ..When comparing our results to the studies carried out by N(2) bubbling, the N(2) bubbling seems to be insufficient to remove the oxygen completely from the solution...
  51. ncbi Collagen cross-linking (CCL) with sequential topography-guided PRK: a temporizing alternative for keratoconus to penetrating keratoplasty
    A John Kanellopoulos
    Laservision gr Institute, Athens, Greece
    Cornea 26:891-5. 2007
    ..To assess the effectiveness of ultraviolet A (UVA) irradiation-induced collagen cross-linking (CCL) on keratoconus (KC) progression...
  52. ncbi New two-photon activated photodynamic therapy sensitizers induce xenograft tumor regressions after near-IR laser treatment through the body of the host mouse
    Jean R Starkey
    Department of Microbiology, Montana State University, Bozeman, MT 59717, USA
    Clin Cancer Res 14:6564-73. 2008
    ..These experiments also evaluated effects of high-energy femtosecond pulsed laser irradiation on normal tissues and characterized the response of xenograft tumors to our PDT protocols...
  53. ncbi In vitro demonstration of the heavy-atom effect for photodynamic therapy
    Aoife Gorman
    Centre for Synthesis and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, Department of Chemistry University College Dublin, Belfield, Dublin 4, Ireland
    J Am Chem Soc 126:10619-31. 2004
    ..All photosensitizers have very low to nondeterminable dark toxicity in our assay system...
  54. pmc Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer
    Yu Cheng
    Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Am Chem Soc 130:10643-7. 2008
    ..With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug...
  55. ncbi Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005
    Lasse R Braathen
    Dermatological University Clinic, Bern, Switzerland
    J Am Acad Dermatol 56:125-43. 2007
    ..PDT may also be a means of preventing certain nonmelanoma skin cancers in immunosuppressed patients...
  56. ncbi Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments
    David B Rein
    Research Triangle Institute International, Research Triangle Park, North Carolina, USA
    Arch Ophthalmol 127:533-40. 2009
    ..To forecast age-related macular degeneration (AMD) and its consequences in the United States through the year 2050 with different treatment scenarios...
  57. ncbi Combination of 10% EDTA, Photosan, and a blue light hand-held photopolymerizer to inactivate leading oral bacteria in dentistry in vitro
    T Maisch
    Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany
    J Appl Microbiol 107:1569-78. 2009
    ....
  58. pmc Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars
    Shouju Wang
    Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu 210000, China
    Adv Mater 25:3055-61. 2013
    ..The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo...
  59. pmc Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes
    Domingo Mariano Adolfo Vera
    Department of Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Mar del Plata, Argentina
    Photochem Photobiol 88:499-511. 2012
    ..This review discusses the different antimicrobial PDT strategies and highlights the need for highly informative and comprehensive discovery approaches...
  60. ncbi Modulation of central corneal thickness by various riboflavin eyedrop compositions in porcine corneas
    Jan M Vetter
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    J Cataract Refract Surg 38:525-32. 2012
    ..To evaluate the modulatory effect of various riboflavin 0.1% and 0.2% compositions on the central corneal thickness (CCT) in fresh porcine corneas...
  61. ncbi Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells
    Xiaoli Wang
    School of Applied Chemistry and Biological, Shenzhen Polytechnic, Shenzhen, Guangdong, People s Republic of China
    J Pharmacol Exp Ther 334:847-53. 2010
    ..Taken together, both cellular and molecular data revealed that HY-PDT could inhibit the growth of CNE-2 cells and induce their apoptosis...
  62. pmc All you need is light: antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease
    Tyler G St Denis
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
    Virulence 2:509-20. 2011
    ....
  63. ncbi Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy
    Hong Yeol Yoon
    Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Biomaterials 33:3980-9. 2012
    ..Overall, it was demonstrated that Ce6-HANPs could be successfully applied to in vivo photodynamic tumor imaging and therapy simultaneously...
  64. pmc Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia
    Maarten A Wildeman
    Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    PLoS ONE 8:e63706. 2013
    ..Here we present routine treatment results in a prospective study on NPC in a top referral; university hospital in Indonesia...
  65. ncbi Photosensitizer encapsulated organically modified silica nanoparticles for direct two-photon photodynamic therapy and in vivo functional imaging
    Jun Qian
    Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, Zhejiang University, Hangzhou, Zhejiang 310058, PR China
    Biomaterials 33:4851-60. 2012
    ..Finally, we showed that the nanoprobes could target the subcutaneously xenografted tumor of a mouse for long time observations. ORMOSIL nanoparticles have great potentials for disease diagnosis and clinical therapies...
  66. ncbi Triple-functional core-shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro
    Xiao Fei Qiao
    Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, PKU HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry, Peking University, Beijing 100871, China
    Nanoscale 4:4611-23. 2012
    ..Compared with the clinical commercial contrast agent Gd-DTPA, the as-fabricated nanomaterial showed a comparable longitudinal relaxivities value (r(1)) and similar imaging effect...
  67. pmc Photodynamic therapy for infections: clinical applications
    Gitika B Kharkwal
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Lasers Surg Med 43:755-67. 2011
    ..This resurgence of interest has been partly motivated by the alarming increase in drug resistance amongst bacteria and other pathogens. This review will focus on the clinical applications of antimicrobial PDT...
  68. ncbi Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus
    Paolo Vinciguerra
    Department of Ophthalmology, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Arch Ophthalmol 127:1258-65. 2009
    ..To report intraoperative and 24-month refractive, topographic, tomographic, and aberrometric outcomes after corneal collagen cross-linking in progressive advanced keratoconus...
  69. ncbi Results of corneal collagen cross-linking in pediatric patients
    Ritu Arora
    Furu Nanak Eye Centre, New Delhi, India
    J Refract Surg 28:759-62. 2012
    ..To evaluate the safety and efficacy of corneal collagen cross-linking (CXL) in the treatment of keratoconus in pediatric patients...
  70. ncbi The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells
    Martina Semeláková
    Institute of Biology and Ecology, Faculty of Sciences, P J Šafárik University in Košice, Moyzesova 11, 040 01 Kosice, Slovakia
    J Photochem Photobiol B 117:115-25. 2012
    ..John's wort, which are increasingly recognized as being able to regulate a variety of pathobiological processes, thus possessing potential therapeutic properties...
  71. ncbi Hypericin in cancer treatment: more light on the way
    Patrizia Agostinis
    Division of Biochemistry, Faculty of Medicine, KULeuven, Leuven, Belgium
    Int J Biochem Cell Biol 34:221-41. 2002
    ..This review focuses on the more recent advances in the use of hypericin as a photodynamic agent and discusses the current knowledge on the signaling pathways underlying its photocytotoxic action...
  72. ncbi Temoporfin (Foscan®, 5,10,15,20-tetra(m-hydroxyphenyl)chlorin)--a second-generation photosensitizer
    Mathias O Senge
    Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James s Hospital, Dublin 8, Ireland
    Photochem Photobiol 87:1240-96. 2011
    ..The literature has been covered up to early 2011...
  73. pmc Photodynamic therapy: novel third-generation photosensitizers one step closer?
    L B Josefsen
    Department of Chemistry, University of Hull, Kingston upon Hull, UK
    Br J Pharmacol 154:1-3. 2008
    ..The lack of tumour specificity may have a significant impact on the potential BAM-SiPc has in clinical PDT...
  74. ncbi Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates
    Tanya Stuchinskaya
    School of Chemistry, University of East Anglia, Norwich, Norfolk, UK
    Photochem Photobiol Sci 10:822-31. 2011
    ..Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents...
  75. ncbi Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a prospective, randomized, double-blind, placebo-controlled phase III study
    R M Szeimies
    Department of Dermatology, Regensburg University Hospital, Regensburg, Germany
    Br J Dermatol 163:386-94. 2010
    ..Different strategies are applied to overcome the chemical instability of ALA in solution and to improve skin penetration. A new stable nanoemulsion-based ALA formulation, BF-200 ALA, is currently in clinical development for PDT of AK...
  76. pmc Analysis of the bacterial heat shock response to photodynamic therapy-mediated oxidative stress
    Tyler G St Denis
    John Jay High School, Cross River, NY, USA
    Photochem Photobiol 87:707-13. 2011
    ..Induction of HSPs may be a mechanism whereby bacteria could become resistant to PDT and warrants the need for further study in the application of dual PDT-HSP-inhibition therapies...
  77. ncbi Targeted photodynamic therapy via receptor mediated delivery systems
    Wesley M Sharman
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Adv Drug Deliv Rev 56:53-76. 2004
    ..This review discusses various PS bioconjugates that utilize these factors and summarizes the results obtained to date...
  78. ncbi Improved photodynamic inactivation of gram-positive bacteria using hematoporphyrin encapsulated in liposomes and micelles
    Tsuimin Tsai
    Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei 110, Taiwan
    Lasers Surg Med 41:316-22. 2009
    ..To increase the efficacy of photosensitizer, hematoporphyrin (Hp) was used as a model drug and encapsulated in liposomes and micelles. The bactericidal efficacy of the carrier-entrapped Hp was assessed against gram-positive bacteria...
  79. ncbi Strategies for enhanced photodynamic therapy effects
    Sarika Verma
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Photochem Photobiol 83:996-1005. 2007
    ....
  80. pmc Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model
    Tianhong Dai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Lasers Surg Med 42:38-44. 2010
    ..The objective of this study was to investigate the efficacy of photodynamic therapy (PDT) for the treatment of MRSA infection in skin abrasion wounds using a mouse model...
  81. ncbi Long-term results of salvage photodynamic therapy for patients with local failure after chemoradiotherapy for esophageal squamous cell carcinoma
    T Yano
    Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Endoscopy 43:657-63. 2011
    ..The aim of this study was to clarify the long-term results of salvage photodynamic therapy (PDT) for local failure...
  82. ncbi Bactericidal effect of malachite green and red laser on Actinobacillus actinomycetemcomitans
    Renato Araujo Prates
    Center for Lasers and Applications, IPEN CNEN SP, Av Prof Lineu Prestes, 2242, Cidade Universitaria, São Paulo SP 05508 000, Brazil
    J Photochem Photobiol B 86:70-6. 2007
    ..Optical absorption showed that MG is photobleached after irradiation. These results indicate that A. actinomycetemcomitans can be photosensitized by red laser combined with MG and that the dye is photodegraded following irradiation...
  83. ncbi Photodynamic antimicrobial chemotherapy (PACT) with methylene blue increases membrane permeability in Candida albicans
    Ligia Maria Giroldo
    Instituto de Pesquisa e Desenvolvimento IP and D, Universidade do Vale do Paraiba UNIVAP, Sao Jose dos Campos, SP, Brazil
    Lasers Med Sci 24:109-12. 2009
    ..The decrease in Candida growth was associated with an increase in membrane permeabilization. Thus, we suggest that a PACT mechanism using MB can be related to damage in the plasma membranes of the cells...
  84. pmc Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy
    Sara B Snell
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 88:596-603. 2012
    ..The data suggest that miconazole could be used to increase the efficacy of PDT against C. albicans, and its mechanism of action is likely to be multifactorial...
  85. ncbi 5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer
    Maung Kyaw Khaing Oo
    Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030, USA
    Nanomedicine (Lond) 3:777-86. 2008
    ..Effective delivery of photosensitizer to target tumor cells that causes minimal damage to healthy cells is an important requirement in photodynamic therapy of cancer...
  86. pmc Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections
    Zongshun Lu
    Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA
    Nanomedicine (Lond) 5:1525-33. 2010
    ..We asked whether this high degree of in vitro activity would translate into an in vivo therapeutic effect in two potentially lethal mouse models of infected wounds...
  87. ncbi Tumor ablation with photodynamic therapy: introduction to mechanism and clinical applications
    Paul Harrod-Kim
    Division of Vascular and Interventional Radiology, Department of Imaging Sciences, University of Rochester, Box 648, 601 Elmwood Avenue, Rochester, New York 14642, USA
    J Vasc Interv Radiol 17:1441-8. 2006
    ....
  88. ncbi Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell
    Chung Wook Chung
    Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Eur J Pharm Biopharm 80:453-8. 2012
    ..Cotreatment with the surfactant resulted in an increased intracellular ALA level, PpIX formation, and phototoxicity...
  89. ncbi Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison with a registered methyl-5-aminolaevulinate cream and placebo
    T Dirschka
    Private Dermatological Practice Centre, Wuppertal, Germany
    Br J Dermatol 166:137-46. 2012
    ..BF-200 ALA (Biofrontera Bioscience GmbH, Leverkusen, Germany) is a gel formulation of ALA with nanoemulsion for the treatment of AK which overcomes previous problems of ALA instability and improves skin penetration...
  90. ncbi Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus
    Beau A Standish
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto, Ontario, Canada
    Gastrointest Endosc 66:326-33. 2007
    ....
  91. pmc Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
    Radiat Res 174:331-40. 2010
    ..Further study of low fluence rate as a means to improve responses to PDT under conditions designed to predominantly damage vasculature is warranted...
  92. ncbi Photodynamic therapy for unresectable cholangiocarcinoma
    Yutaka Tomizawa
    Department of Medicine, University of Pittsburgh Medical Center, 5230 Center Avenue, Pittsburgh, PA 15232, USA
    Dig Dis Sci 57:274-83. 2012
    ..PDT has also been reported to have a favorable outcome as adjuvant and neoadjuvant therapy for CC. Although accumulated data and local expertise are limited, PDT can be regarded as a standard palliative therapy for unresectable CC...
  93. ncbi Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatment
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 84:1141-8. 2008
    ....
  94. ncbi Oncologic photodynamic therapy photosensitizers: a clinical review
    Ron R Allison
    21st Century Oncology, Greenville, NC 27834 3764, USA
    Photodiagnosis Photodyn Ther 7:61-75. 2010
    ..Based on a clinical orientation the qualities of successful photosensitizers will be examined, how current drugs fare and potential future options explored...
  95. ncbi Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus
    Victoria Engelhardt
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria
    Photochem Photobiol Sci 9:365-9. 2010
    ..We suggest both substances as promising candidates for treatment of staphylococcal infections in wounds with APDT...
  96. ncbi The effect of photodynamic treatment combined with antibiotic action or host defence mechanisms on Staphylococcus aureus biofilms
    Antonella Di Poto
    University of Pavia, Department of Biochemistry, Viale Taramelli 3 b, Pavia 27100, Italy
    Biomaterials 30:3158-66. 2009
    ..The results suggest that PDT combined with vancomycin and the host defences may be a useful approach for the inactivation of staphylococcal biofilms adhering to medical implant surfaces...
  97. ncbi Guidelines for the management of actinic keratoses
    D De Berker
    Bristol Dermatology Centre, Bristol Royal Infirmary, Bristol, UK
    Br J Dermatol 156:222-30. 2007
    ..Strength of recommendation includes consideration of apparent cost-benefit and practical considerations. Quality of evidence reflects the nature of the trial structure that provides data of efficacy...
  98. ncbi Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: an in vitro study
    James Chen Yong Kah
    Division of Bioengineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore
    Lasers Surg Med 40:584-9. 2008
    ..We compare the treatment efficacy of such combined treatment with the individual treatment...
  99. ncbi Photodynamic therapy: a review of the literature and image documentation
    Maria Cláudia Almeida Issa
    Universidade Federal Fluminense, Niteroi, RJ, Brasil
    An Bras Dermatol 85:501-11. 2010
    ..This article provides an extensive review of photodynamic therapy, its mechanisms, indications and results...
  100. pmc 5-Aminolevulinic acid-based photodynamic therapy suppressed survival factors and activated proteases for apoptosis in human glioblastoma U87MG cells
    Surajit Karmakar
    Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 323K, Charleston, SC 29425, USA
    Neurosci Lett 415:242-7. 2007
    ..The results suggested that 5-ALA-PDT induced apoptosis in U87MG cells by suppression of survival signals and activation of proteolytic pathways. Thus, 5-ALA-PDT can be an effective strategy for inducing apoptosis in glioblastoma...
  101. ncbi Caspase-independent apoptosis, in human MCF-7c3 breast cancer cells, following photodynamic therapy, with a novel water-soluble phthalocyanine
    Natalia B Rumie Vittar
    Departamento Biologia Molecular, Facultad de Ciencias Exactas, Universidad Nacional de Rio Cuarto, Ruta 8 Km 601, Rio Cuarto, Argentina
    Int J Biochem Cell Biol 42:1123-31. 2010
    ..These data support the notion that an alternative mechanism of caspase-independent apoptosis was found in PoII-photosensitized cells...

Research Grants80

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ....
  4. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..By improving the selectivity of tumor targeting, we can potentially sustain local delivery of PDT drugs, thus dramatically enhancing the success of brain cancer therapy. ..
  5. Iron, NO, and Lipid Peroxide in Photodynamic Therapy
    ALBERT GIROTTI; Fiscal Year: 2013
    ..abstract_text> ..
  6. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
    ..Nanotechnology has made major contributions to BrCa therapy. We propose an innovative nanotechnology-based approach for BrCa prevention and treatment that could significantly impact patient care. ..
  7. Mitochondrial function and antifungal photodynamic therapy
    Constantine G Haidaris; Fiscal Year: 2011
    ..abstract_text> ..
  8. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2013
    ..This provides the potential for rapid screening to establish individualized patient-specific molecular targets and forms the basis for designing personalized prevention and treatments. ..
  9. Mechanisms of Cell Death after Photodynamic Therapy
    Anna Liisa Nieminen; Fiscal Year: 2010
    ..The proposed studies will enhance our understanding how to enhance PDT-induced killing of cancer cells and further increase the efficacy of PDT translation to the benefit for cancer patients. ..
  10. SYNTHESES AND CELLULAR STUDIES OF NEW PHOTOSENSITIZERS FOR MEDICAL APPLICATIONS
    Kevin M Smith; Fiscal Year: 2013
    ..The full potential can be realized only when new drugs with higher cellular selectivity and specificity are discovered, their mechanisms of biological action investigated, and their efficacy evaluated relative to existing modalities. ..
  11. Antimicrobial Phototherapy of Antibiotic Resistant Chronic Sinusitis
    MERRILL ABRAHAM BIEL; Fiscal Year: 2011
    ....
  12. Development of targeted photodynamic therapy for treatment of dental caries
    Randal Eckert; Fiscal Year: 2010
    ..It will encourage and support innovative research from a small business on the etiology, pathogenesis, prevention, diagnosis, and treatment of oral, craniofacial, and dental diseases and disorders. ..
  13. Tri-modal Polymeric Micelles for 'See &Treat'Applications in Surgical Oncology
    Glen S Kwon; Fiscal Year: 2012
    ..Advances in integrated optical imaging and therapeutic capability of biocompatible PEG-b-PCL micelles will enable tenable nano-technology applications in surgical oncology and rapid translation into clinical trials. ..
  14. Combination Therapy With 5-FU and PDT For The Treatment Of Post-Transplant Premal
    Edward V Maytin; Fiscal Year: 2012
    ....
  15. Sphingolipids in Cell Death after Photodamage
    DUSKA M SEPAROVIC; Fiscal Year: 2012
    ..Thus, the proposal holds the promise of improving clinical PDT. ..
  16. A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY
    JINDRICH H KOPECEK; Fiscal Year: 2010
    ..The concept of double-targeted macromolecular therapeutics provides a new paradigm for the design of efficient anticancer drugs for the treatment of ovarian cancer. ..
  17. BASIC SCIENCE RESEARCH IN DIGESTIVE DISEASES
    Mark Donowitz; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: This grant will allow the training of leaders of Gl research, both basic and translational research. ..
  18. EGFR-targeted Polymeric Micelles for Targeted Pc 4-PDT of Oropharyngeal Tumors
    ALYSSA MANECK MASTER; Fiscal Year: 2013
    ..abstract_text> ..
  19. Human PBGS Quaternary Structure Dynamics, Drugs, and Half-of-the-sites Reactivity
    Eileen K Jaffe; Fiscal Year: 2012
    ..Inactivation of human PBGS is involved in the human conditions of ALAD porphyria and lead poisoning, the latter of which remains a pervasive public health problem in the United States and around the world. ..
  20. Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBM
    Brian W Pogue; Fiscal Year: 2013
    ..Quantitative imaging will also accelerate fluorescence-guided resections for GBM already in advanced clinical trials. Finally, the approach developed here will be adaptable to treating a broad range of diseases. ..
  21. Nanoparticle-based Antimicrobial Photochemotherapy in Biofilms
    NIKOLAOS SOUKOS; Fiscal Year: 2010
    ..Our research may help develop photodynamic therapy as a non-invasive technique for prevention, control and/or treatment of periodontal disease. ..
  22. Injectable reporters to image tumors and guide resection
    Roger Y Tsien; Fiscal Year: 2013
    ..genetically perfectly labeling, whether PDT helps, how well can current injectable agents monitor recurrence, and what materials or procedures most need improvement. ..
  23. Therapeutics of XIAP Degradation by Zinc Chelators
    Vladimir M Kolenko; Fiscal Year: 2013
    ..We seek to evaluate the therapeutic uses of 5-ALA for the treatment of hormone refractory prostate cancer. ..
  24. Hyperspectral Microendscopy to Monitor VEGF During Pancreatic Cancer Therapy
    BRYAN QUILTY SPRING; Fiscal Year: 2012
    ..This project integrates new image-guidance and nanotechnology platforms to deliver therapeutic agents at the "right time" and to the "right place" for optimal inhibition of cancer cell survival and metastasis. ..
  25. Porphyrin Conjugates and EGFR
    ALECIA MICHELLE MCCALL; Fiscal Year: 2011
    ..25-35 This research, then, is advantageous in that fluorescent porphyrin-based conjugates be used to selectively and efficiently label CRC tumor foci, which has been illustrated by previous research in our group. ..
  26. Modes of cell death initiated by photodynamic therapy
    David Kessel; Fiscal Year: 2013
    ..We have recently found that PDT evokes a hitherto unreported cellular response: impaired membrane trafficking leading to interference with the endocytic pathway. The implications of this effect remain to be explored. ..
  27. Broncho-adventitial Drug Delivery: Paclitaxel for Bronchial Carcinoma
    KIRK SEWARD; Fiscal Year: 2013
    ..but offer similar benefit. Local bronchial wall delivery of drugs can also be an important treatment as adjuvant therapy for metastatic or benign diseases that cause airway narrowing. ..
  28. Targeted Photoactivatable Nanocells to Image and Treat Metastic Ovarian Cancer
    Tayyaba Hasan; Fiscal Year: 2010
    ..This study has the potential to improve patient care and could result in the development of a new standard of management for the patients with OvCa following surgery. ..
  29. Multimodality Microendoscope for Metastatic Ovarian Cancer Detection & Treatment
    CONOR LEE EVANS; Fiscal Year: 2010
    ..By detecting these metastases, this research aims to vastly improve the detection and subsequent treatment of ovarian cancer to save the lives of women with this disease. ..
  30. Real Time, Automated Singlet Oxygen Dosimeter for PDT
    Steven Davis; Fiscal Year: 2009
    ....
  31. Light Activation of Enzyme Inhibition
    JEREMY KODANKO; Fiscal Year: 2013
    ..Literature data confirm that photodynamic therapy is effective against bone tumors in live animal models, which strongly supports our studies. ..
  32. A Novel Therapy for the Treatment of Chest Wall Progression of Breast Cancer
    Gary S Rogers; Fiscal Year: 2010
    ..This project seeks to develop a novel, low-morbidity approach to treating cancer that can be administered repeatedly and in an outpatient setting. ..
  33. New Stereoregular Functionalized Fullerenes as Nanomedicines for PDT
    Long Y Chiang; Fiscal Year: 2012
    ..Particular chemical and photophysical features of these compounds proposed herein will improve PDT of these diseases beyond what is presently possible. ..
  34. New PET /near IR-fluorescence tools for multimodal imaging in oncology
    Richard Ting; Fiscal Year: 2013
    ..These molecules will possess exterior functionality that is similar to clinical 99mTc tracers in order to address the problem of recurrin 99mTc shortages, a current problem in nuclear medicine today. ..
  35. Light-targeted drug delivery
    MATTHEW C HARTMAN; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: This proposal aims to develop a new versatile method for the treatment of esophageal cancer with light. Light will be used to deliver a chemotherapeutic agent into esophageal cancer cells. ..
  36. Molecular Response and Imaging-based Combination Strategies for Optimal PDT
    Tayyaba Hasan; Fiscal Year: 2013
    ..NMSC on the other hand has many options but the high incidence puts a heavy burden on society in terms of cost and suffering. ..
  37. Neoadjuvant photodynamic immunomodulation for colon cancer
    Edward L Nelson; Fiscal Year: 2011
    ..These studies may provide the basis for the development of new strategies to improve colon cancer survival. ..
  38. Glioblastoma PDT Design: Nanoagent Uptake and Tumor Oxygenation based dosimetry
    Srivalleesha Mallidi; Fiscal Year: 2013
    ..X. Breakefield (GBM tumor biology and animal models), Dr. R. Martuza (clinical translational aspects of GBM-PDT) and Dr. L. Wang at Univ. of Washington (PAI and imaging tumor hypoxia). ..
  39. PDT - Mechanisms and Strategies for Optimization
    Barbara W Henderson; Fiscal Year: 2013
    ..abstract_text> ..
  40. Fluorescence Image-Guided Near Infrared (NIR) Photodynamic Therapy (PDT) Agent
    Manivannan Ethirajan; Fiscal Year: 2013
    ....
  41. Optical Dosimetry for Clinical Trials of Pc 4 Photodynamic Therapy
    THOMAS HARRISON FOSTER; Fiscal Year: 2010
    ..Research proposed here will develop means for measuring the quantities that determine the outcome of this therapy. Results will contribute to the ongoing clinical trials. ..
  42. Intrabiliary MR/RF-enhanced chemotherapy of malignant biliary obstructions
    Xiaoming Yang; Fiscal Year: 2013
    ..Finally, the success of this project should lay the groundwork for development of new technologies to treat obstructive diseases in other luminal systems such as the urinary tract and gastrointestinal tract. ..
  43. Ovarian Cancer PDT: Multi-intracellular targeting and Image-guided dosimetry
    Tayyaba Hasan; Fiscal Year: 2013
    ..The platform will also impact scientific research by providing new investigative tools. ..
  44. Heterocellular 3D ovarian tumor arrays for imaging and mechanistic combinations
    Tayyaba Hasan; Fiscal Year: 2013
    ..Because molecular expressions and responses can be idiosyncratic, the proposed rapid monitoring of biomarkers expression and treatment-induced biomarkers changes creates the possibility of patient-customized treatments in the future. ..
  45. PHTHALOCYANINE PHOTODYNAMIC THERAPY OF SKIN TUMORS
    Hasan Mukhtar; Fiscal Year: 1999
    ..Agents found to be effective will then be tested for abrogation of photosensitivity by administration to mice after Pc-PDT of skin tumors, and reexposure to light radiation vs. controls. ..
  46. Molecular Imaging Directed, 3D Ultrasound-guided, Biopsy System
    Baowei Fei; Fiscal Year: 2013
    ..If completely developed, the multimodality molecular image-guided system will be able to be used not only for biopsy but also for brachytherapy, radiofrequency thermal ablation, cryotherapy, and photodynamic therapy. ..
  47. Quantitative Evaluation of Cerenkov Luminescence for Imaging and Therapy
    Simon R Cherry; Fiscal Year: 2013
    ....
  48. Multifunctional Photosensitizers for Image-guided PDT of Brain Tumors
    Ravindra K Pandey; Fiscal Year: 2012
    ..Therefore, this research warrants further investigation. ..
  49. High-Performance Cone-Beam CT Guidance of Head and Neck Surgery
    Jeffrey H Siewerdsen; Fiscal Year: 2010
    ..g., robot-assisted surgery, photodynamic therapy, and precise targeting using chemical or biological agents) that require a high degree of geometric precision provided by intraoperative imaging. ..
  50. Myocyte-specific nanoplatform-enabling photodynamic cardiac ablation
    Raoul Kopelman; Fiscal Year: 2013
    ....
  51. Oxygen and photosensitizer levels in photodynamic therapy of head and neck tumors
    Theresa M Busch; Fiscal Year: 2013
    ..outcome? Question 3B: Are macroscopic heterogeneities in oxygen and photosensitizer levels measures of underlying microscopic heterogeneities? Question 3C: How are distributions of oxygen and photosensitizer spatially related? ..
  52. Mechanism-based therapies for pancreatic cancer informed by stromal microrheology
    Jonathan P Celli; Fiscal Year: 2012
    ..The opportunities provided by this award will not only allow Dr. Celli to pursue potentially ground-breaking research, but will also provide him with valuable mentorship and training to his career as an independent investigator. ..
  53. A Novel Therapy for the Treatment of Chest Wall Progression of Breast Cancer
    Gary S Rogers; Fiscal Year: 2013
    ..Phase III will involve commercial partners to move CLIPT into pivotal trials and to explore the use of CLIPT in treating additional cancer and proliferative diseases. ..
  54. Effects of Photodynamic Therapy on Tumor Oxygenation and Blood Flow
    Theresa M Busch; Fiscal Year: 2012
    ....
  55. Nanobiophotonics Enabled Tumor Surgery and Intraoperative PDT
    Raoul Kopelman; Fiscal Year: 2010
    ..The ultimate goal is to apply advances in nanotechnology to address the challenges in the surgical and adjuvant therapy of brain tumors. ..
  56. Nanoparticle Enabled Intraoperative Imaging and Therapy
    Raoul Kopelman; Fiscal Year: 2009
    ....
  57. OPTIMIZATION OF INTRAPERITONEAL PDT
    Douglas Fraker; Fiscal Year: 2012
    ..In all parts of the trial malignant and normal tissue will be analyzed for sensitizer concentration, molecular markers related to PDT response, and intraoperatively for optical properties. ..
  58. Multiwavelength diode laser system for PDT
    Kristen M Kelly; Fiscal Year: 2010
    ....
  59. New Strategies for Photoimmunodetection/therapy
    MARK DAVID SAVELLANO; Fiscal Year: 2010
    ..These receptors are ideal targets for PID/PIT since they are often overexpressed and/or overactivated in many cancers, especially aggressive high-risk breast cancers. ..
  60. Imaging and Overcoming Hypoxia-Induced Resistance in Metastatic Ovarian Cancer
    CONOR LEE EVANS; Fiscal Year: 2010
    ....
  61. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..This proposal will be instrumental in the development of a novel PDT drug without long-term restrictions of patients' sun exposure. [unreadable] [unreadable]..
  62. OTHER FUNCTIONS TOPIC 255, PHASE II, "TARGETED TWO-PHOTON PHOTODYNAMIC THERAPY T
    CHARLES SPANGLER; Fiscal Year: 2012
    ..abstract_text> ..
  63. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  64. SELECTIVE PHOTOCHEMOTHERAPY: DEVELOPMENT AND APPLICATION
    Allan Oseroff; Fiscal Year: 1991
    ..The technique of photochemotherapy permits double selectivity, since damage requires the simultaneous presence of a photosensitizer (PS) and ..
  65. LASER PHOTOTHERAPY FOR THE TREATMENT OF MALIGNANCIES
    Dan Castro; Fiscal Year: 1992
    ..Furthermore, the basic unit of dosimetry that will be developed with the lasers ("LAD") will allow standardization of scientific clinical and biomedical research...
  66. LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS
    Michael Berns; Fiscal Year: 2002
    ..Response will be evaluated at 3 month intervals for up to one year post treatment. ..
  67. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
    ....
  68. Photodynamic Therapy for Endodontic Disinfection
    NIKOLAOS SOUKOS; Fiscal Year: 2009
    ..Photodynamic therapy may be an adjunctive procedure to kill residual root canal bacteria after their sensitization with a photoactive drug and their subsequent exposure to light. ..
  69. PULSED SOLID-STATE LASER SOURCE FOR PHOTODYNAMIC THERAPY
    PETER MOULTON; Fiscal Year: 1992
    ..The long term goal would be to develop a clinically qualified solid-state laser for PDT...
  70. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2009
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  71. 3RD BIENNIAL MEETING--PHOTODYNAMIC ASSOCIATION
    Thomas Dougherty; Fiscal Year: 1990
    ..Emphasis will be placed on drug and light source development, as well as the current status of clinical trials and new clinical applications...
  72. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2004
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  73. Photodynamic therapy of oral candidiasis
    CONSTANTINE HAIDARIS; Fiscal Year: 2005
    ..2b. To demonstrate proof of principle of PDT in the treatment of C. albicans infection in the oral cavity of rats in vivo. ..
  74. CHARACTERIZATION OF NEW PHOTOSENSITIZING DYES
    David Kessel; Fiscal Year: 1992
    ..Exploration of these phenomena should facilitate the design of new dyes for PDT...
  75. PHOTOSENSTIZATION MECHANISMS IN HYPOXIC MEDIA
    ROBERT REDMOND; Fiscal Year: 2003
    ..The ability of a PIRG to modulate between oxygen-dependent and independent photosensitization mechanisms in direct response to oxygen levels will be investigated. ..
  76. Photodynamic Therapy of Disseminated Peritoneal Tumor Using New Photosensitizers
    J Wharton; Fiscal Year: 2009
    ..However, the unacceptably low 5-year survival rate necessitates the development of alternative treatments such as photodynamic therapy. ..
  77. Novel Cancer Nanotechnology Platforms for Photodynamic Therapy and Imaging
    Ravindra Pandey; Fiscal Year: 2009
    ..Paras Prasad, PhD (UB), will lead development and photophysical characterization of the Ormosil platform. Raoul Kopelman, PhD (UM), will lead development and photophysical characterization the polyacrylamide platform. ..
  78. Visibly Caged Bio-active Molecules and PDT
    Paul Jones; Fiscal Year: 2004
    ..abstract_text> ..
  79. Singlet Oxygen Detector for Photodynamic Therapy
    Steven Davis; Fiscal Year: 2004
    ..Finally a real time O2 (1delta) monitor during phototherapy could be an invaluable tool for improving the efficiency of cancer cell destruction. ..
  80. PRECLINICAL INTERSTITIAL PHOTODYNAMIC THERAPY RESEARCH
    J Chapman; Fiscal Year: 1992
    ....