Genomes and Genes
Summary: The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.
Publications351 found, 100 shown here
- The molecular genetics of crop domesticationJohn F Doebley
Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
Cell 127:1309-21. 2006....
- Prediction of total genetic value using genome-wide dense marker mapsT H Meuwissen
Research Institute of Animal Science and Health, 8200 AB Lelystad, The Netherlands
Genetics 157:1819-29. 2001..It was concluded that selection on genetic values predicted from markers could substantially increase the rate of genetic gain in animals and plants, especially if combined with reproductive techniques to shorten the generation interval...
- Invited review: Genomic selection in dairy cattle: progress and challengesB J Hayes
Department of Primary Industries Victoria, Biosciences Research Division, Bundoora, Australia
J Dairy Sci 92:433-43. 2009A new technology called genomic selection is revolutionizing dairy cattle breeding. Genomic selection refers to selection decisions based on genomic breeding values (GEBV)...
- Whole-genome regression and prediction methods applied to plant and animal breedingGustavo de Los Campos
Department of Biostatistics, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
Genetics 193:327-45. 2013Genomic-enabled prediction is becoming increasingly important in animal and plant breeding and is also receiving attention in human genetics...
- Genome-wide genetic changes during modern breeding of maizeYinping Jiao
State Key Laboratory of Agrobiotechnology and National Maize Improvement Center, China Agricultural University, Beijing, People s Republic of China
Nat Genet 44:812-5. 2012The success of modern maize breeding has been demonstrated by remarkable increases in productivity over the last four decades. However, the underlying genetic changes correlated with these gains remain largely unknown...
- Breeding technologies to increase crop production in a changing worldMark Tester
Australian Centre for Plant Functional Genomics, University of Adelaide, South Australia SA 5064, Australia
Science 327:818-22. 2010..Hence, new technologies must be developed to accelerate breeding through improving genotyping and phenotyping methods and by increasing the available genetic diversity in ..
- The impact of genetic relationship information on genome-assisted breeding valuesD Habier
Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
Genetics 177:2389-97. 2007The success of genomic selection depends on the potential to predict genome-assisted breeding values (GEBVs) with high accuracy over several generations without additional phenotyping after estimating marker effects...
- Development and evaluation of a 9K SNP array for peach by internationally coordinated SNP detection and validation in breeding germplasmIgnazio Verde
CRA Fruit Tree Research Center, Rome, Italy
PLoS ONE 7:e35668. 2012..number of single nucleotide polymorphism (SNP) markers covering the entire genome are needed to enable molecular breeding efforts such as genome wide association studies, fine mapping, genomic selection and marker-assisted selection in ..
- Next-generation sequencing technologies and their implications for crop genetics and breedingRajeev K Varshney
Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru 502324, A P, India
Trends Biotechnol 27:522-30. 2009..introgression, epigenetic modifications, transcript profiling, population genetics and de novo genome/organellar genome assembly for which these technologies are expected to advance crop genetics and breeding, leading to crop improvement.
- Analysis of copy number variations among diverse cattle breedsGeorge E Liu
USDA ARS, ANRI, Bovine Functional Genomics Laboratory, Beltsville, Maryland 20705, USA
Genome Res 20:693-703. 2010..Our results provide a valuable resource beyond microsatellites and single nucleotide polymorphisms to explore the full dimension of genetic variability for future cattle genomic research...
- Improving accuracy of genomic predictions within and between dairy cattle breeds with imputed high-density single nucleotide polymorphism panelsM Erbe
Department of Animal Sciences, Animal Breeding and Genetics Group, Georg August University Gottingen, 37075 Gottingen, Germany
J Dairy Sci 95:4114-29. 2012Achieving accurate genomic estimated breeding values for dairy cattle requires a very large reference population of genotyped and phenotyped individuals...
- Efficient mapping of mendelian traits in dogs through genome-wide associationElinor K Karlsson
Broad Institute of Harvard and Massachusetts Institute of Technology MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Genet 39:1321-8. 2007....
- Deregressing estimated breeding values and weighting information for genomic regression analysesDorian J Garrick
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
Genet Sel Evol 41:55. 2009Genomic prediction of breeding values involves a so-called training analysis that predicts the influence of small genomic regions by regression of observed information on marker genotypes for a given population of individuals...
- Genetic architecture of complex traits and accuracy of genomic prediction: coat colour, milk-fat percentage, and type in Holstein cattle as contrasting model traitsBen J Hayes
Biosciences Research Division, Department of Primary Industries Victoria, Melbourne, Victoria, Australia
PLoS Genet 6:e1001139. 2010Prediction of genetic merit using dense SNP genotypes can be used for estimation of breeding values for selection of livestock, crops, and forage species; for prediction of disease risk; and for forensics...
- Prediction of genetic values of quantitative traits in plant breeding using pedigree and molecular markersJose Crossa
School of Land Crop and Food Sciences, University of Queensland, 4072, Sta Lucia, Queensland, Australia
Genetics 186:713-24. 2010The availability of dense molecular markers has made possible the use of genomic selection (GS) for plant breeding. However, the evaluation of models for GS in real plant populations is very limited...
- Mapping genes for complex traits in domestic animals and their use in breeding programmesMichael E Goddard
Department of Agriculture and Food Systems, University of Melbourne, Royal Parade, Parkville 3010, Australia
Nat Rev Genet 10:381-91. 2009..This approach is expected to double the rate of genetic improvement per year in many livestock systems...
- Genomic selection: prediction of accuracy and maximisation of long term responseMike Goddard
Department of Primary Industries, University of Melbourne, Victoria, Australia
Genetica 136:245-57. 2009Genomic selection refers to the use of dense markers covering the whole genome to estimate the breeding value of selection candidates for a quantitative trait...
- A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studiesMolly E McCue
College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA
PLoS Genet 8:e1002451. 2012..These results demonstrate the high quality of this SNP genotyping resource, its usefulness in diverse genome analyses of the horse, and potential use in related species...
- Genomic selection in plant breeding: from theory to practiceJean Luc Jannink
USDA ARS, R W Holley Center for Agriculture and Health, Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853, USA
Brief Funct Genomics 9:166-77. 2010..Selection can be based on GS predictions, potentially leading to more rapid and lower cost gains from breeding. The objectives of this article are to review essential aspects of GS and summarize the important take-home ..
- A single IGF1 allele is a major determinant of small size in dogsNathan B Sutter
National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892 8000, USA
Science 316:112-5. 2007..A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs...
- Genome-wide footprints of pig domestication and selection revealed through massive parallel sequencing of pooled DNAAndreia J Amaral
Animal Breeding and Genomics Centre, Wageningen University, Wageningen, The Netherlands
PLoS ONE 6:e14782. 2011..Artificial selection has caused rapid evolution in domesticated species. The identification of selection footprints across domesticated genomes can contribute to uncover the genetic basis of phenotypic diversity...
- Identification of genomic regions associated with phenotypic variation between dog breeds using selection mappingAmaury Vaysse
Institut de Génétique et Développement de Rennes, CNRS UMR6061, Universite de Rennes 1, Rennes, France
PLoS Genet 7:e1002316. 2011..Further elucidation of the variants under selection will help to uncover the genetic basis of complex traits and disease...
- Genome-wide SNP detection, validation, and development of an 8K SNP array for appleDavid Chagne
Plant and Food Research, Palmerston North Research Centre, Palmerston North, New Zealand
PLoS ONE 7:e31745. 2012As high-throughput genetic marker screening systems are essential for a range of genetics studies and plant breeding applications, the International RosBREED SNP Consortium (IRSC) has utilized the Illumina Infinium® II system to develop ..
- Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domesticationBridgett M VonHoldt
Department of Ecology and Evolutionary Biology, 621 Charles E Young Drive South, University of California, Los Angeles, California 90095, USA
Nature 464:898-902. 2010..More recently, the evolution of modern dog breeds seems to have been an iterative process that drew on a limited genetic toolkit to create remarkable phenotypic diversity...
- Imputation of genotypes with low-density chips and its effect on reliability of direct genomic values in Dutch Holstein cattleH A Mulder
Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, PO Box 65, 8200 AB Lelystad, The Netherlands
J Dairy Sci 95:876-89. 2012..selection using 50,000 single nucleotide polymorphism (50k SNP) chips has been implemented in many dairy cattle breeding programs. Cheap, low-density chips make genotyping of a larger number of animals cost effective...
- The importance of information on relatives for the prediction of genomic breeding values and the implications for the makeup of reference data sets in livestock breeding schemesSamuel A Clark
University of New England, Armidale, NSW 2351, Australia
Genet Sel Evol 44:4. 2012..This study aimed to examine the importance of information on relatives versus that of unrelated or more distantly related individuals on the estimation of genomic breeding values.
- High-density SNP genotyping of tomato (Solanum lycopersicum L.) reveals patterns of genetic variation due to breedingSung Chur Sim
Department of Horticulture and Crop Science, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH, USA
PLoS ONE 7:e45520. 2012..LD decay varied between chromosomes and sub-populations, with large differences reflective of breeding history. For example, on chromosome 11, decay occurred over 0.8 cM for processing accessions and over 19...
- Different models of genetic variation and their effect on genomic evaluationSamuel A Clark
School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia
Genet Sel Evol 43:18. 2011..Therefore, a better understanding of what genomic selection actually predicts is relevant so that appropriate methods of analysis are used in genomic evaluations...
- Footprints of selection in the ancestral admixture of a New World Creole cattle breedMathieu Gautier
INRA, UMR CBGP INRA CIRAD IRD Supagro, Montferrier sur Lez, France
Mol Ecol 20:3128-43. 2011..This study illustrates the relevance of admixed populations to identify footprints of selection by combining several tests straightforward to implement on large data sets...
- Application of site and haplotype-frequency based approaches for detecting selection signatures in cattleSaber Qanbari
Animal Breeding and Genetics Group, Department of Animal Sciences, Georg August University, 37075 Gottingen, Germany
BMC Genomics 12:318. 2011....
- Design of a bovine low-density SNP array optimized for imputationDidier Boichard
UMR1313 Animal Genetics and Integrative Biology, National Institute for Agricultural Research INRA, Jouy en Josas, France
PLoS ONE 7:e34130. 2012..The minor allele frequencies were similar across taurine beef and dairy breeds as was the proportion of SNPs that were polymorphic. The new BovineLD chip should facilitate low-cost genomic selection in taurine beef and dairy cattle...
- Genomic selectionM E Goddard
University of Melbourne, Attwood, Australia
J Anim Breed Genet 124:323-30. 2007..Simulation results and limited experimental results suggest that breeding values can be predicted with high accuracy using genetic markers alone but more validation is required especially ..
- Accuracies of genomic breeding values in American Angus beef cattle using K-means clustering for cross-validationMahdi Saatchi
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
Genet Sel Evol 43:40. 2011Genomic selection is a recently developed technology that is beginning to revolutionize animal breeding. The objective of this study was to estimate marker effects to derive prediction equations for direct genomic values for 16 routinely ..
- Effect of imputing markers from a low-density chip on the reliability of genomic breeding values in Holstein populationsR Dassonneville
INRA, UMR1313 Génétique Animale et Biologie Intégrative GABI, 78350 Jouy en Josas, France
J Dairy Sci 94:3679-86. 2011..investigate the imputation error and loss of reliability of direct genomic values (DGV) or genomically enhanced breeding values (GEBV) when using genotypes imputed from a 3,000-marker single nucleotide polymorphism (SNP) panel to a 50,..
- Accuracy of prediction of genomic breeding values for residual feed intake and carcass and meat quality traits in Bos taurus, Bos indicus, and composite beef cattleS Bolormaa
Victorian Department of Primary Industries, Bundoora, VIC 3083, Australia
J Anim Sci 91:3088-104. 2013..All traits appear to be highly polygenic with thousands of SNP independently associated with each trait. ..
- Mapping QTL for agronomic traits in breeding populationsTobias Würschum
State Plant Breeding Institute, University of Hohenheim, 70593 Stuttgart, Germany
Theor Appl Genet 125:201-10. 2012Detection of quantitative trait loci (QTL) in breeding populations offers the advantage that these QTL are of direct relevance for the improvement of crops via knowledge-based breeding...
- Bridging the genotyping gap: using genotyping by sequencing (GBS) to add high-density SNP markers and new value to traditional bi-parental mapping and breeding populationsJennifer Spindel
Department of Plant Breeding and Genetics, Cornell University, 162 Emerson Hall, Ithaca, NY, 14853 1901, USA
Theor Appl Genet 126:2699-716. 2013..general interest "reference" genomes, the low cost of GBS makes it an attractive means of saturating mapping and breeding populations with a high density of SNP markers...
- Linking deforestation to malaria in the Amazon: characterization of the breeding habitat of the principal malaria vector, Anopheles darlingiAmy Y Vittor
Department of Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Trop Med Hyg 81:5-12. 2009This study examined the larval breeding habitat of a major South American malaria vector, Anopheles darlingi, in areas with varying degrees of ecologic alteration in the Peruvian Amazon...
- Hot topic: a unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final scoreI Aguilar
Animal and Dairy Science Department, University of Georgia, Athens 30602 Instituto Nacional de Investigación Agropecuaria, Las Brujas 90200, Uruguay
J Dairy Sci 93:743-52. 2010..Advantages of single-step evaluations should increase in the future when animals are pre-selected on genotypes...
- The accuracy of Genomic Selection in Norwegian red cattle assessed by cross-validationTu Luan
Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Box 5003, N 1432 As, Norway
Genetics 183:1119-26. 2009Genomic Selection (GS) is a newly developed tool for the estimation of breeding values for quantitative traits through the use of dense markers covering the whole genome...
- Genomic prediction of simulated multibreed and purebred performance using observed fifty thousand single nucleotide polymorphism genotypesK Kizilkaya
Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
J Anim Sci 88:544-51. 2010..Improved across breed prediction of genomic merit will require panels with more than 50,000 markers...
- Genetic effects of captive breeding cause a rapid, cumulative fitness decline in the wildHitoshi Araki
Department of Zoology, 3029 Cordley Hall, Oregon State University Corvallis, OR 97331, USA
Science 318:100-3. 2007Captive breeding is used to supplement populations of many species that are declining in the wild. The suitability of and long-term species survival from such programs remain largely untested, however...
- Distribution and location of genetic effects for dairy traitsJ B Cole
Animal Improvement Programs Laboratory, ARS, USDA, Beltsville, MD 20705 2350, USA
J Dairy Sci 92:2931-46. 2009..Additive genetic merits were constructed for each chromosome, and the distribution of BTA14-specific estimated breeding value (EBV) showed that selection primarily for milk yield has not changed the distribution of EBV for fat ..
- A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chickenBen Dorshorst
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 7:e1002412. 2011..This complex genomic rearrangement causing a specific monogenic trait in the chicken illustrates how novel mutations with major phenotypic effects have been reused during breed formation in domestic animals...
- Prediction of unobserved single nucleotide polymorphism genotypes of Jersey cattle using reference panels and population-based imputation algorithmsK A Weigel
Department of Dairy Science, University of Wisconsin, Madison, Wisconsin 53706, USA
J Dairy Sci 93:2229-38. 2010..SNP) genotypes for dairy cattle has created exciting research opportunities and revolutionized practical breeding programs...
- Identification of selection signatures in cattle breeds selected for dairy productionAlessandra Stella
Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, 20133 Milan, Italy
Genetics 185:1451-61. 2010....
- Technical note: an R package for fitting generalized linear mixed models in animal breedingA I Vazquez
Department of Dairy Science, University of Wisconsin, Madison 53706, USA
J Anim Sci 88:497-504. 2010..Estimation methods available in pedigreemm include approximations to maximum likelihood and REML. This note describes the classes of models that can be fitted using pedigreemm and presents examples that illustrate its use...
- Identifying loci influencing 1,000-kernel weight in wheat by microsatellite screening for evidence of selection during breedingLanfen Wang
Key Laboratory of Crop Germplasm Resources and Utilization, Ministry of Agriculture, The National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China
PLoS ONE 7:e29432. 2012..84% of the total phenotypic variation. Favored alleles for breeding at the 22 loci were inferred according to their estimated effects on MTKW based on mean difference of varieties ..
- Population structure and genetic differentiation associated with breeding history and selection in tomato (Solanum lycopersicum L.)S C Sim
Department of Horticulture and Crop Science, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA
Heredity (Edinb) 106:927-35. 2011..These subpopulations correspond to historical patterns of breeding conducted for specific production environments...
- Prediction of response to marker-assisted and genomic selection using selection index theoryJ C M Dekkers
Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011 3150, USA
J Anim Breed Genet 124:331-41. 2007..By specifying estimates of breeding values derived from marker information (M-EBV) as a correlated trait with heritability equal to 1, it was ..
- The impact of genetic relationship information on genomic breeding values in German Holstein cattleDavid Habier
Institute of Animal Breeding and Husbandry, Christian Albrechts University of Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
Genet Sel Evol 42:5. 2010..of additive-genetic relationships captured by single nucleotide polymorphisms (SNPs) on the accuracy of genomic breeding values (GEBVs) has been demonstrated, but recent studies on data obtained from Holstein populations have ignored ..
- A common reference population from four European Holstein populations increases reliability of genomic predictionsMogens S Lund
Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, AU Foulum, PO Box 50, DK 8830 Tjele, Denmark
Genet Sel Evol 43:43. 2011..Increased accuracies of genomic predictions depend on the number of individuals added to the reference population, the reliability of their phenotypes, and the relatedness of the populations that are combined...
- Identifying the most productive breeding sites for malaria mosquitoes in The GambiaUlrike Fillinger
Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, UK
Malar J 8:62. 2009..Despite the plethora of potential mosquito breeding sites found in the floodplains of the Gambia River, about 150 km from its mouth, during the rainy season, only a ..
- A genome wide survey of SNP variation reveals the genetic structure of sheep breedsJames W Kijas
CSIRO Livestock Industries, St Lucia, Brisbane, Queensland, Australia
PLoS ONE 4:e4668. 2009..Furthermore, the identification of a subset of SNP able to assign individuals into broad groupings demonstrates even a small panel of markers may be suitable for applications such as traceability...
- A validated genome-wide association study in 2 dairy cattle breeds for milk production and fertility traits using variable length haplotypesJ E Pryce
Biosciences Research Division, Department of Primary Industries Victoria, Bundoora 3083, Australia
J Dairy Sci 93:3331-45. 2010..Promising candidate genes have been identified in several of the validated regions...
- Genomic prediction when some animals are not genotypedOle F Christensen
Aarhus University, Faculty of Agricultural Sciences, Dept of Genetics and Biotechnology, Blichers alle 20, PO Box 50, DK 8830 Tjele, Denmark
Genet Sel Evol 42:2. 2010The use of genomic selection in breeding programs may increase the rate of genetic improvement, reduce the generation time, and provide higher accuracy of estimated breeding values (EBVs)...
- Genome-wide genetic association of complex traits in heterogeneous stock miceWilliam Valdar
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Genet 38:879-87. 2006..Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits...
- Anopheles gambiae s.s. breeding in polluted water bodies in urban Lagos, southwestern NigeriaT S Awolola
Public Health Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria
J Vector Borne Dis 44:241-4. 2007Urban malaria is on the rise in Nigeria due to rapid industrialisation and developmental activities. A study was undertaken in Lagos, Nigeria to study the Anopheles breeding in polluted water bodies.
- Population genetics of genomics-based crop improvement methodsMartha T Hamblin
Institute for Genomic Diversity, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
Trends Genet 27:98-106. 2011....
- Accuracy of genomic selection in European maize elite breeding populationsYusheng Zhao
State Plant Breeding Institute, University of Hohenheim, 70599, Stuttgart, Germany
Theor Appl Genet 124:769-76. 2012Genomic selection is a promising breeding strategy for rapid improvement of complex traits. The objective of our study was to investigate the prediction accuracy of genomic breeding values through cross validation...
- Deregressed EBV as the response variable yield more reliable genomic predictions than traditional EBV in pure-bred pigsTage Ostersen
The Danish Agricultural and Food Council, Pig Research Centre, Breeding and Genetics, Axeltorv 3, DK 1609, Denmark
Genet Sel Evol 43:38. 2011..For pure-bred pigs, it was hypothesised that deregressed estimated breeding values (EBV) with the parent average removed as the response variable generate higher reliabilities of genomic ..
- Allele coding in genomic evaluationIsmo Strandén
Biotechnology and Food Research, MTT Agrifood Research Finland, FI 31600 Jokioinen, Finland
Genet Sel Evol 43:25. 2011Genomic data are used in animal breeding to assist genetic evaluation. Several models to estimate genomic breeding values have been studied. In general, two approaches have been used...
- Will genomic selection be a practical method for plant breeding?Akihiro Nakaya
Center for Transdisciplinary Research, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8585, Japan
Ann Bot 110:1303-16. 2012..GS is a form of MAS that selects favourable individuals based on genomic estimated breeding values...
- Genomic inbreeding and relationships among Holsteins, Jerseys, and Brown SwissP M Vanraden
Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
J Dairy Sci 94:5673-82. 2011..Pedigree relationship matrices ignore common ancestry shared by base animals within breed and may not approximate genomic relationships well in multibreed populations...
- Genome wide signatures of positive selection: the comparison of independent samples and the identification of regions associated to traitsWilliam Barendse
Commonwealth Scientific and Industrial Research Organization, Queensland Bioscience Precinct, St Lucia, Queensland, Australia
BMC Genomics 10:178. 2009..The goal of genome wide analyses of polymorphisms is to achieve a better understanding of the link between genotype and phenotype. Part of that goal is to understand the selective forces that have operated on a population...
- Association mapping of iron deficiency chlorosis loci in soybean (Glycine max L. Merr.) advanced breeding linesJu Wang
Department of Plant Sciences, North Dakota State University, Fargo, ND 58105 5051, USA
Theor Appl Genet 116:777-87. 2008..Two independent soybean populations consisting of advanced breeding lines representing the diversity within maturity groups 00, 0, and I were screened in multi-site, replicated ..
- Comparative analyses of genetic trends and prospects for selection against hip and elbow dysplasia in 15 UK dog breedsThomas W Lewis
Kennel Club Genetics Centre at the Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
BMC Genet 14:16. 2013..Many researchers have recommended the use of estimated breeding values (EBV) to improve the rate of genetic progress from selection against hip and elbow dysplasia (another ..
- Incorporation of competitive effects in forest tree or animal breeding programsWilliam M Muir
Department of Animal Science, Purdue University, West Lafayette, Indiana 47907 1151, USA
Genetics 170:1247-59. 2005..usual quantitative genetic model ignores these competitive interactions and could result in seriously incorrect breeding decisions and acerbate animal well-being...
- SNP discovery and linkage map construction in cultivated tomatoKenta Shirasawa
Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
DNA Res 17:381-91. 2010..then screened against cultivated tomato lines in order to estimate the transferability of these SNPs to other breeding materials...
- Genome-wide association scan and phased haplotype construction for quantitative trait loci affecting boar taint in three pig breedsVivi R Gregersen
Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, P, O, Box 50, DK 8830 Tjele, Denmark
BMC Genomics 13:22. 2012..In the study presented in this paper, markers and haplotypes, which can be applied to DNA-based selection schemes in order to reduce or eliminate the boar taint problem, are identified...
- Four loci explain 83% of size variation in the horseShokouh Makvandi-Nejad
Department of Clinical Sciences, Cornell University, Ithaca, New York, United States of America
PLoS ONE 7:e39929. 2012..Our results in the horse, complemented by the prior work in cattle and dog, serve to pinpoint those very few genes that have played major roles in the rapid evolution of size during domestication...
- Breeding for high water-use efficiencyA G Condon
CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
J Exp Bot 55:2447-60. 2004There is a pressing need to improve the water-use efficiency of rain-fed and irrigated crop production. Breeding crop varieties with higher water-use efficiency is seen as providing part of the solution...
- Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroidsEli Grindflek
NORSVIN The Norwegian Pig Breeders Association, 2304 Hamar, Norway
BMC Genomics 12:362. 2011..This represents a challenge when performing selection against androstenone in breeding programs, without simultaneously decreasing levels of other steroids...
- Genome-wide association study for calving traits in Danish and Swedish Holstein cattleG Sahana
Aarhus University, Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Research Centre Foulum, DK 8830, Tjele, Denmark
J Dairy Sci 94:479-86. 2011..The identification of calving trait-associated single nucleotide polymorphisms and mapping of the corresponding QTL in small chromosomal regions will facilitate the search for candidate calving performance genes and polymorphisms...
- Experimental evidence for density-dependent reproduction in a cooperatively breeding passerineLyanne Brouwer
Evolutionary Ecology Group, School of Botany and Zoology, Australian National University, Canberra, ACT 0200 Australia
Ecology 90:729-41. 2009..Islands with the highest insect densities also had the highest bird densities and the largest breeding groups...
- Factors affecting accuracy from genomic selection in populations derived from multiple inbred lines: a Barley case studyShengqiang Zhong
Department of Agronomy, Iowa State University, Ames, Iowa 50011, USA
Genetics 182:355-64. 2009..True breeding values (TBV) were simulated on the basis of 20 or 80 additive QTL...
- Linkage disequilibrium decay and haplotype block structure in the pigAndreia J Amaral
Animal Breeding and Genomics Centre, Wageningen UR, 6700AH, Wageningen, The Netherlands
Genetics 179:569-79. 2008..First, the European ancestral stock had a higher level of LD. Second, modern breeding programs increased the extent of LD in Europe and caused differences of LD between genomic regions...
- Accuracy of genomic breeding values in multi-breed dairy cattle populationsBen J Hayes
Biosciences Research Division, Department of Primary Industries Victoria, Bundoora, Australia
Genet Sel Evol 41:51. 2009..are 1) the reference population used must be very large to subsequently predict accurate genomic estimated breeding values (GEBV), and 2) prediction equations derived in one breed do not predict accurate GEBV when applied to ..
- Highly focused anopheline breeding sites and malaria transmission in DakarVanessa Machault
Unité d entomologie médicale, Equipe 7 Maladies Emergentes et Moustiques, Institut de Medecine Tropicale du Service de Sante des Armees, Allée du Médecin Colonel Jamot, Parc du Pharo, 13262 Marseille cedex 07, France
Malar J 8:138. 2009..heterogeneity of malaria transmission was investigated in Dakar, in order to characterize the Anopheles breeding sites in the city and to study the dynamics of larval density and adult aggressiveness in ten characteristically ..
- Integrated genomics, physiology and breeding approaches for improving drought tolerance in cropsReyazul Rouf Mir
International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, Hyderabad 502 324, India
Theor Appl Genet 125:625-45. 2012..Modern genomics and genetic approaches coupled with advances in precise phenotyping and breeding methodologies are expected to more effectively unravel the genes and metabolic pathways that confer drought ..
- Breeding for water-saving and drought-resistance rice (WDR) in ChinaL J Luo
Shanghai Agrobiological Gene Center, 2901 Beidi Road, Shanghai 201106, China
J Exp Bot 61:3509-17. 2010..The breeding target is a high yield potential under irrigation, an acceptable grain quality, and water consumption reduced by ..
- Metabolomics-assisted breeding: a viable option for crop improvement?Alisdair R Fernie
Max Planck Institute für Molekulare Pfanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
Trends Genet 25:39-48. 2009..Metabolomics represents an important addition to the tools currently employed in genomics-assisted selection for crop improvement...
- The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems geneticsElissa J Chesler
Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Bldg 1059 MS 6420, P O Box 2008, Oak Ridge, TN 37831 6420, USA
Mamm Genome 19:382-9. 2008..to investigate biomolecular networks and systems-level phenotypes underlying complex traits, we have initiated breeding of a new genetic reference population of mice, the Collaborative Cross...
- DArT markers for the rye genome - genetic diversity and mappingHanna Bolibok-Bragoszewska
Department of Plant Genetics, Breeding and Biotechnology, Warsaw University of Life Sciences SGGW, 02 776 Warsaw, Poland
BMC Genomics 10:578. 2009Implementation of molecular breeding in rye (Secale cereale L.) improvement programs depends on the availability of high-density molecular linkage maps...
- Precocious flowering in trees: the FLOWERING LOCUS T gene as a research and breeding tool in PopulusHuanling Zhang
Northwest A and F University, College of Forestry, Yangling, 712100 People s Republic of China
J Exp Bot 61:2549-60. 2010..of FT should be of particular use in forest trees, as it could greatly accelerate and enable new kinds of breeding and research...
- Genome-wide association and genomic selection in animal breedingBen Hayes
Biosciences Research Division, Department of Primary Industries Victoria, 1 Park Drive, Bundoora 3083, Australia
Genome 53:876-83. 2010..The genomic breeding values are predicted to be the sum of the effect of these SNPs across the entire genome...
- Feasibility and implications of breeding sheep for resilience to nematode challengeS A Bisset
AgResearch Wallaceville, Upper Hutt, New Zealand
Int J Parasitol 26:857-68. 1996..Our results suggest that the main benefits of selectively breeding for low FEC are likely to be derived indirectly as a result of reduced pasture contamination...
- More genomic resources for less-studied cropsRajeev K Varshney
International Crops Research Institute for the Semi Arid Tropics, Patancheru 502324, A P, India
Trends Biotechnol 28:452-60. 2010..These resources have the potential to accelerate gene discovery and initiate molecular breeding in these crops, thereby enhancing crop productivity to ensure food security in developing countries.
- Identification and characterization of large-effect quantitative trait loci for grain yield under lowland drought stress in rice using bulk-segregant analysisRamaiah Venuprasad
Plant Breeding Genetics and Biotechnology Division, International Rice Research Institute, DAPO Box 7777, Manila, Philippines
Theor Appl Genet 120:177-90. 2009..The Apo alleles for these large-effect QTL for grain yield under drought and aerobic conditions may be immediately exploited in marker-assisted-breeding to improve the drought tolerance of Swarna.
- Reliability of genomic predictions across multiple populationsA P W de Roos
Biosciences Research Division, Department of Primary Industries Victoria, University of Melbourne, Bundoora 3083, Australia
Genetics 183:1545-53. 2009..Our results suggest that the most accurate genomic predictions are achieved when phenotypes from all populations are combined in one training set, while for more diverged populations a higher marker density is required...
- Complete chloroplast genome of Oncidium Gower Ramsey and evaluation of molecular markers for identification and breeding in OncidiinaeFu Hui Wu
Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
BMC Plant Biol 10:68. 2010..However, they are amenable to intergeneric and inter-specific crossing making phylogenetic identification very difficult. Molecular markers derived from the chloroplast genome can provide useful tools for phylogenetic resolution...
- Flowering time control and applications in plant breedingChristian Jung
Plant Breeding Institute, Christian Albrechts University of Kiel, D 24098 Kiel, Germany
Trends Plant Sci 14:563-73. 2009Shifting the seasonal timing of reproduction is a major goal of plant breeding efforts to produce novel varieties that are better adapted to local environments and changing climatic conditions...
- Population structure and genetic diversity in a commercial maize breeding program assessed with SSR and SNP markersDelphine Van Inghelandt
Institute of Plant Breeding, Seed Science, and Population Genetics, University of Hohenheim, 70593, Stuttgart, Germany
Theor Appl Genet 120:1289-99. 2010Information about the genetic diversity and population structure in elite breeding material is of fundamental importance for the improvement of crops...
- Shifts in caterpillar biomass phenology due to climate change and its impact on the breeding biology of an insectivorous birdMarcel E Visser
Netherlands Institute of Ecology NIOO KNAW, P O Box 40, 6666 ZG, Heteren, The Netherlands
Oecologia 147:164-72. 2006..The birds will start breeding earlier and this advancement is predicted to be at the same rate as the advancement of the food peak, and hence ..
- High-resolution haplotype block structure in the cattle genomeRafael Villa-Angulo
Department of Bioinformatics and Computational Biology, George Mason University, VA, USA
BMC Genet 10:19. 2009..6 Mb with an average density of approximately one SNP per 4 kb, and characterized the linkage disequilibrium (LD) and haplotype block structure within individual breeds and groups of breeds in relation to their geographic origin and use...
- Genetic diversity within and between European pig breeds using microsatellite markersM SanCristobal
Laboratoire de Genetique Cellulaire, Institut National de la Recherche Agronomique, 31326 Castanet Tolosan Cedex, France
Anim Genet 37:189-98. 2006..This study has consequences for the interpretation of biodiversity results and will be of importance for future conservation programmes...
- Accuracy of genotypic value predictions for marker-based selection in biparental plant populationsRobenzon E Lorenzana
Department of Agronomy and Plant Genetics, University of Minnesota, 411 Borlaug Hall, 1991 Upper Buford Circle, Saint Paul, MN 55108, USA
Theor Appl Genet 120:151-61. 2009The availability of cheap and abundant molecular markers has led to plant-breeding methods that rely on the prediction of genotypic value from marker data, but published information is lacking on the accuracy of genotypic value ..
- Biodiversity of pig breeds from China and Europe estimated from pooled DNA samples: differences in microsatellite variation between two areas of domesticationHendrik Jan Megens
Wageningen University, Animal Breeding and Genomics Centre, PO Box 338, 6700AH, Wageningen, The Netherlands
Genet Sel Evol 40:103-28. 2008..A likely cause is a more diverse wild boar population in Asia, but various other possible contributing factors are discussed...
- Short interspersed elements (SINEs) are a major source of canine genomic diversityWei Wang
The Institute for Genomic Research, Rockville, Maryland 20850, USA
Genome Res 15:1798-808. 2005....
- Anopheles culicifacies breeding in brackish waters in Sri Lanka and implications for malaria controlPavilupillai J Jude
Department of Zoology, Faculty of Science, University of Jaffna, Jaffna, Sri Lanka
Malar J 9:106. 2010..subpictus exists as a complex of species A-D. The freshwater breeding habit of An. culicifacies is well established...
- Breeding value prediction for production traits in layer chickens using pedigree or genomic relationships in a reduced animal modelAnna Wolc
Department of Genetics and Animal Breeding, University of Life Sciences in Poznan, Wołyńska st, 33, 60 637 Poznan, Poland
Genet Sel Evol 43:5. 2011Genomic selection involves breeding value estimation of selection candidates based on high-density SNP genotypes...
- Physiological role of PRDM16 in brown fat development and energy balancePatrick Seale; Fiscal Year: 2011..These animals are currently breeding with wildtype mice to establish germ-line transmission of the targeted allele...
- Genetics and Haloperidol ResponseRobert J Hitzemann; Fiscal Year: 2012..analysis, sequence data and functional genomics, high throughput DNA sequencing, the use of short term selective breeding to confirm the role of Drd2 network coherence in haloperidol response and the integration of the QTL and network ..
- Tobacco Control Research Branch Scientific and Technical Services SupportKOURTNEY MARSHALL; Fiscal Year: 2009..relate to the "targeting" of special populations; 9) Tobacco growing practices, particularly those dealing with breeding and genetics which change the tobacco and tobacco smoke constituents; 10) The epidemiologic, clinical or ..
- Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic ManipulationsPetr Tvrdik; Fiscal Year: 2013..because all the required tools can be brought together by breeding. This technology will make it possible to stimulate, for example, a specific population of neurons with channel ..
- BONE MATRIX AND BONE RESORPTIONPaul R Odgren; Fiscal Year: 2012..We are maintaining an ongoing out-crossed breeding project to narrow the candidate region and are sequencing genes in the chromosome interval containing the ..
- Remote-control mouse-implantable micropumps for establishment of regenerative capJUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010..genetic engineering, which is difficult to do with more than one regulator simultaneously and also requires breeding for generations and is thus slow, or by mechanically connecting the mouse to a pump via an external tether, which ..
- Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.David E Clapham; Fiscal Year: 2013..generated mice lacking the TRPC4, TRPC5, both TRPC4 and TRPC5 genes, obtained the TRPC1 knockout mouse, and are breeding TRPC1/4/5 triple knockout mice...
- Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol ACHERYL SUSAN ROSENFELD; Fiscal Year: 2010..Herein, we will determine whether BPA can exert transgenerational effects by breeding black (a/a) females to viable yellow (Avy/a) males...
- Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesisJames Maclean; Fiscal Year: 2009..Mice which lack the Rhox5 gene exhibit abnormalities in sperm number, sperm motility, and breeding efficiency...
- Development of a Porcine Model of AtherosclerosisChristopher Rogers; Fiscal Year: 2012..Finally, we will establish breeding herds to generate LDLR-/- pigs and to expand and propagate the colony...
- Genetics of Spontaneous Pelvic Organ Prolapse in the MouseJay E Reeder; Fiscal Year: 2010..The phenotype has been isolated from the transgene in FVB/N mice by selective breeding. It is inherited as an autosomal dominant trait, is seen in both males and females and no precipitating event (..
- STRUCTURE AND FUNCTION OF HEPARIN COFACTOR IIDouglas M Tollefsen; Fiscal Year: 2010..b>Breeding studies will be done to determine whether neonatal mortality is related to maternal, paternal, or fetal HCII ..
- Astrocytes Play a Critical Role in the Pathology of EAEJOHN ROLAND BETHEA; Fiscal Year: 2013..The first mouse line (73.12xffIKKb) is obtained by breeding a GFAP-Cre line developed in Dr...
- Maternal Hyperinsulinemia and Fetal ProgrammingMulchand S Patel; Fiscal Year: 2011..2-HC rats will be generated by breeding 1-HC female rats with normal male rats...
- Development of a Porcine Model of Ataxia-TelangiectasiaChristopher Rogers; Fiscal Year: 2013..Finally, we will establish long-term breeding herds...
- Defining evolutionary trajectories: Molecular adaptation to antibiotic resistanceADIL YOUSIF SHAMOO; Fiscal Year: 2012..Hospitals and farms can therefore act as breeding grounds and reservoirs for the transfer of drug resistance genes into the general community...
- Modulation of Ca Control of Cardiac MyofibrilsR John Solaro; Fiscal Year: 2013..In Aim #3 our approach is to determine whether cross-breeding a familial DCM mouse model linked to a tropomyosin mutation with the miR208a-KO mouse is able to rescue the DCM ..
- Pathological Evaluation of a Cystic Fibrosis Ferret ModelJohn F Engelhardt; Fiscal Year: 2010..for easier propagation without intestinal obstruction, and establishment of a corporate partnership for breeding and disseminating this model to the research community-will greatly impact research on the multi-organ aspects of ..
- Mechanisms of glucagon-like peptide 1 (GLP-1) in fatty liver diseaseFrank A Anania; Fiscal Year: 2013..establishing 1) a dietary model capable of inducing NAFLD and hepatocyte insulin resistance;and 2) successful breeding of a tissue-specific knockout mouse for the GLP-1 receptor (GLP-1R) in the liver, GLP-1RCre+/flox/flox confirmed ..
- Omega-3 fat to reduce risk for breast cancerWANDA ELAINE HARDMAN; Fiscal Year: 2010..b>Breeding females will be fed one of two diets containing either a high percentage of omega 6 or a high percentage of omega ..
- BRAIN LIPID METABOLISM, DENDRITES AND SYNAPSES IN AGING AND ALZHEIMER'S DISEASEGuojun Bu; Fiscal Year: 2013..if overexpressed LRP1 in mouse brains is sufficient to rescue lipid and synaptic impairments in apoE4-TR mice by breeding apoE3-TR and apoE4-TR mice with LRP1 transgenic mice...
- The evolutionary and molecular mechanisms underlying sperm performance in an emerHeidi S Fisher; Fiscal Year: 2013..In species in which females mate multiple times over a breeding season, there is intense competition between ejaculates of different males for fertilization of her eggs...
- BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDSPAUL STEVEN BERNSTEIN; Fiscal Year: 2013..diets through dietary adjuvants, upregulation of intestinal uptake by moderate vitamin A deficiency, and cross breeding of various transgenic mice targeted to the carotenoid metabolic pathways...
- ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONYThomas J Rowell; Fiscal Year: 2011..from the wild for research purposes;and the National Institutes of Health (NIH) created the `Chimpanzee Breeding and Research Program (CBRP)...
- Symbiotic Rickettsia Species as a Model System for the Study of Folate BiosynthesJianmin Zhong; Fiscal Year: 2012..Arthropods that feed primarily or entirely on blood are virtually a breeding ground for these types of partnerships because vertebrate blood rarely contains sufficient quantities of ..
- MOLECULAR NEUROBIOLOGY OF DRUG ADDICTIONEric J Nestler; Fiscal Year: 2013..The Transgenic Core (PI, Eric Nestler) is responsible for breeding the many lines of transgenic and knockout mice, and for constructs for viral-mediated gene transfer, to be ..
- Genetic determinants of susceptibility to mycobacterial infectionsPhilippe Gros; Fiscal Year: 2013..characterizing a series of congenic and subcongenic mouse strains, in which Trl3 has been isolated by selective breeding. The minimal genetic interval will be carefully scrutinized for the presence of positional candidates that will ..
- The Kiss1 system in the neuroendocrine control of reproductionVICTOR MANUEL NAVARRO; Fiscal Year: 2013..We will use genetically engineered mice that express Cre recombinase and GFP under the Kiss1 promoter. Breeding to homozygosity would lead to Kiss1 deficient (but Cre/GFP positive) mice...
- Chimpanzee Biomedical Research Program Limited Competition (U42)M Babette Fontenot; Fiscal Year: 2013..In 1986 the National Institutes of Health created the Chimpanzee Breeding and Research Program (CBRP) to insure that a chimpanzee population in the United States was available for use in ..
- The Biosynthesis of AnandamideDale G Deutsch; Fiscal Year: 2010..major limitation of a conventional NAPE-PLD-/-, we propose to develop an adult conditional NAPE-PLD knockout by breeding mice in which the exon encoding the enzyme's catalytic residues is floxed...
- The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the ReinstaCharles Chavkin; Fiscal Year: 2009..Pilot funding is required because genotyping, breeding, housing, and testing of these mice in the immunohistochemical and behavioral assays proposed require an ..
- Immune Tolerance and AutoimmunityAbul K Abbas; Fiscal Year: 2010..will create new genetically modified mouse strains, maintain strains shared by all projects, and assist with breeding and genotyping for genetic studies...
- A semi field trial test on efficacy of transgenic antimalarial biocontrol fungiRaymond J St Leger; Fiscal Year: 2013..will consist of experimental huts (mimicking traditional housing), sugar sources (plants) for adults and created breeding sites (plastic containers), enclosed in a greenhouse frame with walls of mosquito netting to allow exposure to ..
- Aflatoxin B1 hepatocarcinogenesis in the mGSTA3-/- mouseStewart Sell; Fiscal Year: 2013..The models will be designed to target oval cells, mimic initiation + promotion protocols and include cross-breeding with chronic hepatitis-prone transgenic mice...
- Rho Kinase and Airway HyperresponsivenessStephanie A Shore; Fiscal Year: 2013..ROCKs in smooth muscle during OVA challenge using smooth muscle specific ROCK1 and ROCK2 knockdowns generated by breeding conditional ROCK1 and ROCK2 knockout mice (floxed mice) to transgenic mice expressing Cre recombinase under ..
- Defining a clinically relevant time point for astrocyte targeted therapy in ALSBrian K Kaspar; Fiscal Year: 2013..Indeed, it has been shown that the reduction of mtSOD1 expression in astrocytes by breeding transgenic mice contacting the floxed mtSOD1 with mice expressing Cre from the glial fibrillary acidic protein (..
- INVESTIGATIONS OF MAMMALIAN AMINOPROPYLTRANSFERASESANTHONY PEGG; Fiscal Year: 2009..the presence of spermine in their diets;and preliminary results indicating that restoring a source of spermine by breeding female Gy carrier mice with CAG-SpmS mice restores normal growth and fertility to these mice despite the ..
- The Ecology, Emergence and Pandemic Potential of Nipah virus in BangladeshPeter Daszak; Fiscal Year: 2012..NiV spillover risk from bats to humans is a factor of fruit bat population biology, especially their synchronous breeding patterns...
- Transgenic Mouse Models of FUS/TLS-Mediated Amyotrophic Lateral SclerosisZuoshang Xu; Fiscal Year: 2010..This strategy will allow the selection and breeding of founder animals even if the mutant gene is highly toxic...
- Seasonality of Mood: A Genome-Wide Association Study in the Old Order AmishTeodor T Postolache; Fiscal Year: 2010..many animals manifest marked seasonal changes in physiology and behavior, such as those related to hibernation, breeding and migration...
- Construct novel influenza A (H1N1) virus chimeric HA genes for development of broVICTOR CHESTER HUBER; Fiscal Year: 2010..spread of novel swine-origin H1N1 influenza viruses, this proposed study will test the feasibility of a molecular breeding (DNA shuffling) approach to create novel HA genes of influenza H1N1 viruses for development of broadly protective ..
- Endothelial NOS by protein to protein interactionsWilliam C Sessa; Fiscal Year: 2013..Interestingly, breeding ApoE/ Cav-1 KO double KO (dKO) mice to EC specific Cav-1 transgenic mice (Cav-1 RC) to reconstitute Cav-1 and ..
- Research on inhalation toxicology of environmental chemicalsROBERT O'CONNER; Fiscal Year: 2012..In addition animal breeding colonies were set up for 4 strains of genetically-modified mice from unapproved sources...
- College of Medicine Phoenix Campus Vivarium Phase I ConstructionWilliam M Crist; Fiscal Year: 2010..Rooms will be provided for breeding of transgenic mice lines, specialized behavioral assays of rats and mice, animal biosafety level 2 (ABSL2) ..
- Development & Characterization of Tyrosinase Epitope Specific TCR Transgenic MiceShikhar Mehrotra; Fiscal Year: 2010..This objective will be accomplished by breeding our TIL1383i/Tg mice with commercially available HLA-A2 and HLA-A/H2-Db mice...
- The Role of Heme Oxygenase-1 in the Immune ResponseJames F George; Fiscal Year: 2013..by the PIs, including i) a transgenic floxed HO-1 mouse strain permitting selective expression of HO-1 by cross-breeding with the appropriate cre recombinants;a CD11c-DC specific HO-1 overexpressing strain;ii) a GFP+ HO-1-/- mouse ..
- Genetics and biology of a viable mutant mouse with dystonic movementsKathleen J Sweadner; Fiscal Year: 2013..with high penetrance;adult-onset;a lack of incapacitating deficits;lifespan of at least 18 months so far;and easy breeding. Although the symptoms are severe, a key feature is that the mice are capable of normal walking and running on a ..
- Sound Source Segregation Mark A Bee; Fiscal Year: 2013..calls of individual males from the overlapping signals of other males and the general din of noise in a large breeding chorus...
- Cortisol regulation of perinatal adipose tissue and sheep neonatal leptin peakStephen P Ford; Fiscal Year: 2013..as: 1) C;ewes fed 100% diet pre-, during and after pregnancy or 2) MO, ewes fed 150% diet from 60 d before breeding, during and after pregnancy...
- Astrocyte Function in Genetic Mouse Models of Autism Spectrum DisordersBruce D Trapp; Fiscal Year: 2013..b>Breeding of these fluorescently tagged astrocytes into genetic models of ASDs will permit astrocyte isolation by ..
- An Integrated Nano-Cell Delivery Platform of Theranostics for Lung CancersSubhra Mohapatra; Fiscal Year: 2013..In this aim, it is planned to establish a model of spontaneous lung cancer by breeding LSL-K-ras- G12D mice with CC10- Cretg mice to generate CC10-Cre-LSL-K-ras G12D mice and to evaluate the efficacy ..
- TILLING Wheat for Reduced Celiac Disease Causing ProteinsCHARLES PAUL MOEHS; Fiscal Year: 2010..organism) technique invented by an Arcadia Biosciences scientist that is a target-selected variation of mutation breeding. During STTR phase I research we have also determined the importance of a DNA 5- methylcytosine deglycosylase for ..
- Role of Calpastatin in mutant SOD1-mediated motor neuron diseaseMala V Rao; Fiscal Year: 2010..We will use mouse breeding techniques, Southern Blotting, polymerase chain reactions, immunoblotting, immunocytochemistry, electron ..
- The Impact of Maternal Health and Diet on Development of Fetal Metabolic SystemsKENT L R THORNBURG; Fiscal Year: 2013..For these studies, breeding NHPs will be chronically maintained on a diet high in fats and calories (HFD)...
- MOLECULAR &CELLULAR MECHANISMS IN TRANSFUSION MEDICINEPeter J Newman; Fiscal Year: 2013..The Transgenic/Knockout Mouse Core will assist with vector design, transgenic mouse production, multi-trait breeding, and animal husbandry...
- BRIT1, A NOVEL HEPATOCELLULAR CARCINOMA TUMOR SUPPRESSORKaiyi Li; Fiscal Year: 2012..to oncogenic stress (c-myc), we will generate the double mutant mice (Alb- cMyc/BRIT1flox/flox/Alb-Cre) by breeding the BRIT1 conditional knockout with Alb-cMyc transgenic mice...
- Cellular and Genetic Basis of Systemic LupusShu Man Fu; Fiscal Year: 2013..C57Lc1 recombinant congenic strain Lc1(1.34Mb) that contains the 1.34Mb of interest by intercross breeding (NZM2328X507-2)F1 X (NZM2328X507-2)F1;Specific Aim 2: To identify a set of contiguous overlapping genomic clones (..
- IMMUNITY AND PATHOGENESIS OF A NOVEL NOROVIRUSHerbert W Virgin; Fiscal Year: 2012..a significant proportion of laboratory mice, requiring a significant investment in developing a closed mouse breeding colony to generate non-immune mice with which to perform immunology and pathogenesis experiments...
- Genetic basis of sperm competition in PeromyscusHeidi S Fisher; Fiscal Year: 2010..In species where females mate multiple times over a breeding season, there is intense competition between ejaculates of different males for fertilization of her eggs...
- Epigenetics underlies long-term risk of relapse during abstinenceKristine M Wiren; Fiscal Year: 2013..contributions, both sexes of an animal model with widely divergent responses to alcohol derived by selective breeding, the Withdrawal Seizure-Resistant (WSR) and Withdrawal Seizure-Prone (WSP) lines, were analyzed...
- STAT3 Functional Defects and a Novel Therapeutic Approach for Hyper IgE SyndromeHans Ochs; Fiscal Year: 2009..Finally, we have established a breeding colony of WAS deficient (KO) mice that will allows us to study in vivo the immune defect caused by mutations of ..
- Physiologic role of the gamma epithelial sodium channel subunit in the kidneyDonald E Kohan; Fiscal Year: 2010..b>Breeding of these animals will result in distal nephron-knockout of ? ENaC...
- EID - Effects of avian migration & anthropogenic change on the distribution & traThomas Smith; Fiscal Year: 2009..the role that North American migratory passerines play in the dispersion of avian influenza strains between breeding sites in Canada and the U.S. and wintering sites in Mexico and Central and South America...
- Ochlerotatus japonicus: Ecology of an Invasive MosquitoRICHARD FALCO; Fiscal Year: 2005..Oc. japonicus uses a wide variety of breeding sites that encompass urban, suburban, and rural habitats, including those inhabited by Culex pipiens, the primary ..
- DEVELOPMENT OF A SPF PIGTAIL MACAQUE BREEDING COLONYROBERT DRUILHET; Fiscal Year: 2000..The initial objective is to establish a breeding colony of SPF defined feral pigtail macaques capable of producing subsequent breeder stock of native born SPF M...
- MAINTENANCE OF A RODENT BREEDING AND HOLDING FACILITYRONALD SCHUELER; Fiscal Year: 1993Maintain and provide for the care and breeding of genetically defined rabbits (approximately 600 past the age of weaning). House rabbits in cage meeting Government requirements and provided by the Government...
- NEUROENDOCRINE CONTROL OF REPRODUCTIVE BEHAVIORLAUREN RITERS; Fiscal Year: 2003..During the breeding season, song in male starlings (Sturnus vulgaris) is observed prior to pair formation and copulation and likely ..
- SPECIFIC PATHOGEN FREE MACAQUE BREEDING PROGRAMM Izard; Fiscal Year: 1999..drug therapy and for basic sciences research, requiring that the government establish and maintain macaque breeding colonies free of the known simian retroviruses and Herpes B virus...
- A Novel Device Design for Sperm CryopreservationERIK WOODS; Fiscal Year: 2009..However, maintenance of these lines by standard breeding techniques is producing unsustainable pressure on facilities and budgets...
- Novel accelerated in vitro breeding for phytoremediationMIHALY CZAKO; Fiscal Year: 2007..The long-term goal of the collaboration between the USC and Southern Sun BioSystems is to create a plant breeding and remediation technology-development center which would supply hardware, protocols for breeding-selection and ..
- PHOTOPERIODIC CONTROL OF REPRODUCTION: EFFECTS OF AGEFred Turek; Fiscal Year: 2001..change in day length is the major environmental factor regulating the timing of reproduction in many seasonally breeding mammals...
- BREEDING BIOLOGY AND BEHAVIOR OF MONOGAMOUS PRIMATESCharles Snowdon; Fiscal Year: 2006DESCRIPTION (provided by applicant): The cotton-top tamarin is a cooperatively breeding monkey living in family groups. Infant care taking is divided among group members with fathers and older siblings doing most infant carrying...