hyperhomocysteinemia

Summary

Summary: An inborn error of methionone metabolism which produces an excess of homocysteine in the blood. It is often caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and is a risk factor for coronary vascular disease.

Top Publications

  1. ncbi Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
  2. doi Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress
    Maureane Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC 27705, USA
    Med Hypotheses 77:1088-93. 2011
  3. pmc Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Ave, B1, New York, NY 10032 USA
    Environ Health Perspect 117:254-60. 2009
  4. pmc Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?
    Jia Min Zhuo
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Trends Pharmacol Sci 32:562-71. 2011
  5. ncbi Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function
    N Weiss
    Medizinische Poliklinik Innenstadt, Klinikum der Universitat Munchen, Pettenkoferstrasse 8a, D 80336 MUnchen, Germany
    Curr Drug Metab 6:27-36. 2005
  6. ncbi Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population
    Ralph Green
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Chem Lab Med 43:1048-51. 2005
  7. ncbi The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease
    Helga Refsum
    Norwegian Institute of Public Health, Oslo, Norway
    J Nutr 136:1731S-1740S. 2006
  8. ncbi Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    H Refsum
    Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
    Am J Clin Nutr 74:233-41. 2001
  9. ncbi Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition
    Z Chen
    Departments of Biology, Human Genetics and Pediatrics, Department of Medicine, Department of Pathology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Hum Mol Genet 10:433-43. 2001
  10. ncbi Homocysteine trials--clear outcomes for complex reasons
    Joseph Loscalzo
    N Engl J Med 354:1629-32. 2006

Detail Information

Publications360 found, 100 shown here

  1. ncbi Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
    ..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies...
  2. doi Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress
    Maureane Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC 27705, USA
    Med Hypotheses 77:1088-93. 2011
    ..A large body of data links hyperhomocysteinemia and folate status with oxidant stress...
  3. pmc Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Ave, B1, New York, NY 10032 USA
    Environ Health Perspect 117:254-60. 2009
    ..Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility...
  4. pmc Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?
    Jia Min Zhuo
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Trends Pharmacol Sci 32:562-71. 2011
    ..by the observation that patients with histologically confirmed AD had higher plasma levels of Hcy, termed hyperhomocysteinemia (HHcy), than age-matched controls...
  5. ncbi Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function
    N Weiss
    Medizinische Poliklinik Innenstadt, Klinikum der Universitat Munchen, Pettenkoferstrasse 8a, D 80336 MUnchen, Germany
    Curr Drug Metab 6:27-36. 2005
    ..This may contribute to endothelial dysfunction observed in hyperhomocysteinemia, and promote atherosclerotic vascular disease...
  6. ncbi Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population
    Ralph Green
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Chem Lab Med 43:1048-51. 2005
    Prevalence rates for folate deficiency and hyperhomocysteinemia have been markedly reduced following the introduction of folic acid fortification in the United States...
  7. ncbi The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease
    Helga Refsum
    Norwegian Institute of Public Health, Oslo, Norway
    J Nutr 136:1731S-1740S. 2006
    ..Overall, the findings from HHS indicate that a raised tHcy level is associated with multiple clinical conditions, whereas a low tHcy level is associated with better physical and mental health...
  8. ncbi Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    H Refsum
    Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
    Am J Clin Nutr 74:233-41. 2001
    ..In India, most people adhere to a vegetarian diet, which may lead to cobalamin deficiency...
  9. ncbi Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition
    Z Chen
    Departments of Biology, Human Genetics and Pediatrics, Department of Medicine, Department of Pathology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Hum Mol Genet 10:433-43. 2001
    b>Hyperhomocysteinemia, a risk factor for cardiovascular disease, is caused by nutritional and/or genetic disruptions in homocysteine metabolism...
  10. ncbi Homocysteine trials--clear outcomes for complex reasons
    Joseph Loscalzo
    N Engl J Med 354:1629-32. 2006
  11. pmc H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
    Taurai Chiku
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 284:11601-12. 2009
    ..However, the relative importance of homocysteine-derived H(2)S increases progressively with the grade of hyperhomocysteinemia, and under conditions of severely elevated homocysteine (200 microm), the alpha,gamma-elimination and gamma-..
  12. ncbi Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis
    Anna Verkleij-Hagoort
    Department of Obstetrics and Gynecology Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Am J Med Genet A 143:952-60. 2007
    Several studies have reported an association between hyperhomocysteinemia, 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and cleft lip with or without cleft palate (CLP), and congenital heart defects (CHDs)...
  13. ncbi High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status
    Ling Hao
    Institute of Reproductive and Child Health, Peking University, Beijing 100083, China, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Nutr 137:407-13. 2007
    ..0 micromol/L, a level used to define hyperhomocysteinemia. Within each region, men had higher plasma tHcy concentrations than women (16.1 vs. 10...
  14. doi Cysteinemia, rather than homocysteinemia, is associated with plasma apolipoprotein A-I levels in hyperhomocysteinemia: lipid metabolism in cystathionine beta-synthase deficiency
    Mario Nuño-Ayala
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Instituto Aragones de Ciencias de la Salud, Universidad de Zaragoza Salud del Gobierno de Aragon, Spain
    Atherosclerosis 212:268-73. 2010
    Genetic and dietary hyperhomocysteinemia has been found to decrease high density lipoproteins (HDL) and their apolipoprotein A1 (APOA1)...
  15. pmc Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia
    Neetu Tyagi
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 S Preston Street, Louisville, KY 40202, USA
    J Cell Biochem 98:1150-62. 2006
    ..Our data suggested that Hcy-mediated ROS production promotes endothelial cell death in part by disturbing MP, which results in subsequent release of cytochrome-c and activation of caspase-9 and 3, leading to cell death...
  16. doi Relationship of homocysteine with other risk factors and outcome of ischemic stroke
    Jayantee Kalita
    Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow 226014, India
    Clin Neurol Neurosurg 111:364-7. 2009
    b>Hyperhomocysteinemia (HH) is an emerging risk factor for ischemic stroke but its role in outcome is controversial. We compare the risk factors, nature of stroke and outcome of patients with and without hyperhomocysteinemia.
  17. pmc Hyperhomocysteinemia promotes insulin resistance by inducing endoplasmic reticulum stress in adipose tissue
    Yang Li
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 10091, China
    J Biol Chem 288:9583-92. 2013
    ..Previously, we found that hyperhomocysteinemia (HHcy) induced insulin resistance in adipose tissue...
  18. pmc Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress
    Xu Wang
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Mol Cell Cardiol 52:753-60. 2012
    ..In this study we explored the effects of hyperhomocysteinemia (HHcy) on myocardial function ex vivo and examined the direct effects of Hcy on cardiomyocyte function and ..
  19. doi Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population
    K K Sukla
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India
    Eur J Clin Nutr 66:111-8. 2012
    ..To assess the incidence of hyperhomocysteinemia and its correlation with the polymorphism in homocysteine (Hcy)-pathway genes and associated cofactors in ..
  20. doi Short hypoxia could attenuate the adverse effects of hyperhomocysteinemia on the developing rat brain by inducing neurogenesis
    Sébastien A Blaise
    INSERM U724, Faculte de Medecine, Vandoeuvre les Nancy, France
    Exp Neurol 216:231-8. 2009
    ..Therefore, by stimulating neurogenesis in rat pups, brief neonatal hypoxia appeared to attenuate the long-term effects of early exposure to a deficiency in nutritional determinants of hyperhomocysteinemia.
  21. pmc High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway
    Elena Bravo
    Department of Cellular Biology and Neuroscience, Istituto Superiore Sanita, Rome, Italy
    Lipids Health Dis 10:60. 2011
    b>Hyperhomocysteinemia (HHcy) causes increased oxidative stress and is an independent risk factor for cardiovascular disease...
  22. doi Homocysteine levels and the metabolic syndrome in a Mediterranean population: a case-control study
    Amparo Vaya
    Hemorheology and Hemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain vaya
    Clin Hemorheol Microcirc 47:59-66. 2011
    b>Hyperhomocysteinemia (HH) and metabolic syndrome (MS) are associated with increased cardiovascular risk...
  23. pmc The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis
    Meg J Jardine
    George Institute For Global Health, PO Box M201, Camperdown, NSW 2050, Australia
    BMJ 344:e3533. 2012
    ..To systematically review the effect of folic acid based homocysteine lowering on cardiovascular outcomes in people with kidney disease...
  24. ncbi Hyperhomocysteinemia in acute Plasmodium falciparum malaria: an effect of host-parasite interaction
    R Chillemi
    Department of Chemical Sciences, University of Catania, Catania, Italy
    Clin Chim Acta 348:113-20. 2004
    ..Plasmodium falciparum utilises the polyamine pathway, essential in proliferation and differentiation, and imposes an oxidative stress on host cell, enhancing the loss of glutathione...
  25. ncbi Celiac sprue, hyperhomocysteinemia, and MTHFR gene variants
    Gilbert M Wilcox
    Department of Medicine, Division of Gastroenterology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Clin Gastroenterol 40:596-601. 2006
    To describe the association of untreated celiac disease with hyperhomocysteinemia and variants of the methylenetetrahydrofolicacid reductase (MTHFR) gene found in clinical practice.
  26. pmc Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, VA 23298, USA
    Hypertension 53:90-6. 2009
    ..action of homocysteine on glomeruli and thereby contributes to the development of glomerulosclerosis during hyperhomocysteinemia. We found that, among Vav members, Vav2 was abundantly expressed in glomeruli...
  27. pmc Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia
    R T Eberhardt
    Evans Department of Medicine, Whitaker Cardiovascular Institute, and Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 106:483-91. 2000
    ..species and a subsequent loss of nitric oxide bioactivity contribute to endothelial dysfunction in mild hyperhomocysteinemia. We examined endothelial function and in vivo oxidant burden in mice heterozygous for a deletion in the ..
  28. doi Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity
    Yunfei Wu
    College of Life Sciences, Graduate University of Chinese Academy of Sciences, Yuquan Road 19 A, 100049 Beijing, China
    Atherosclerosis 212:351-5. 2010
    ..However, their correlations with CAD were not clear. Dysfunction of thioredoxin/thioredoxin reductase (TrxR) may cause oxidative stress that is common to CAD. We seek to determine the association among homocysteine, Trx/TrxR and CAD...
  29. ncbi 5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women
    Iris P Fohr
    Department of Pathophysiology of Human Nutrition, Institute of Nutritional Science, University of Bonn, Germany
    Am J Clin Nutr 75:275-82. 2002
    ..Supplementation with folic acid (FA) decreases plasma tHcy, but limited data are available on the effect of 5-methyltetrahydrofolate (MTHF)...
  30. doi Vascular and biochemical risk factors of vascular dementia after lacunar strokes (S-VaD) and after multiinfarcts in strategic areas (M-VaD)
    Ałła Graban
    First Department of Neurology and Institute of Psychiatry and Neurology, Warsaw, Poland
    J Neurol Sci 283:116-8. 2009
    ..Of biochemical risk factors, hyperhomocysteinemia (associated with low levels of folic acid and vitamin B 12) and low HDL cholesterol levels were found in ..
  31. doi Plasma vitamins, amino acids, and renal function in postexercise hyperhomocysteinemia
    Rafael Venta
    Service of Biochemistry, Hospital San Agustin, Aviles, Principado de Asturias, Spain
    Med Sci Sports Exerc 41:1645-51. 2009
    ....
  32. doi Iatrogenic hyperhomocysteinemia in patients with metabolic syndrome: a systematic review and metaanalysis
    George Ntaios
    First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, Thessaloniki, Greece
    Atherosclerosis 214:11-9. 2011
    ..Therefore, drug-induced hyperhomocysteinemia in MetS patients may add one cardiovascular risk factor in these high-risk patients...
  33. ncbi Plasma homocysteine in obese, overweight and normal weight hypertensives and normotensives
    Rubina A Karatela
    Jaslok Hospital and Research Centre, 15, Dr G Deshmukh Marg, Mumbai 26
    Indian Heart J 61:156-9. 2009
    ..The aim of the present study was to assess the interrelationship of obesity with plasma homocysteine levels as well as vitamin B12 and folic acid levels in hypertensive and normotensive subjects...
  34. ncbi TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia
    Gazi S Hossain
    Department of Pathology and Molecular Medicine, McMaster University and the Henderson Research Centre, Hamilton, Ontario L8V 1C3, Canada
    J Biol Chem 278:30317-27. 2003
    b>Hyperhomocysteinemia is an independent risk factor for cardiovascular disease and accelerates atherosclerosis in apoE-/- mice...
  35. ncbi Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine
    M C Stühlinger
    Section of Vascular Medicine, Stanford University, Stanford, California, USA
    Circulation 104:2569-75. 2001
    b>Hyperhomocysteinemia is a putative risk factor for cardiovascular disease, which also impairs endothelium-dependent vasodilatation...
  36. ncbi Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes
    Yoshimasa Aso
    Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    Diabetes Care 26:2622-7. 2003
    ....
  37. ncbi Hyperhomocysteinemia, DNA methylation and vascular disease
    Md S Jamaluddin
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Clin Chem Lab Med 45:1660-6. 2007
    b>Hyperhomocysteinemia (HHcy) has been established as a potent independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is largely unknown...
  38. pmc Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial
    Andrew G Bostom
    Rhode Island Hospital, 110 Lockwood Street, Providence, RI 02903, USA
    Circulation 123:1763-70. 2011
    ..Observational studies of patients with chronic kidney disease suggest increased homocysteine is a risk factor for cardiovascular disease. The impact of lowering total homocysteine levels in kidney transplant recipients is unknown...
  39. ncbi The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    D J Gaughan
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 157:451-6. 2001
    Epidemiological evidence has revealed that an elevated plasma homocysteine level (hyperhomocysteinemia) confers an increased risk of cardiovascular disease and neural tube defects. Hyperhomocysteinemia is caused by both nutritional (e.g...
  40. ncbi The controversy over homocysteine and cardiovascular risk
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Norway
    Am J Clin Nutr 72:324-32. 2000
    ..3) tHcy is related to renal function, and hyperhomocysteinemia may reflect early nephrosclerosis...
  41. pmc Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P and S 17 501, New York, NY 10032, USA
    J Clin Invest 107:675-83. 2001
    Although hyperhomocysteinemia (HHcy) is a well-known risk factor for the development of cardiovascular disease, the underlying molecular mechanisms are not fully elucidated...
  42. pmc Orchestrating the unfolded protein response in health and disease
    Randal J Kaufman
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650, USA
    J Clin Invest 110:1389-98. 2002
  43. ncbi DACH-LIGA homocystein (german, austrian and swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: guidelines and recommendations
    Olaf Stanger
    Landesklinik für Herzchirurgie, Landeskliniken Salzburg, Salzburg, Austria
    Clin Chem Lab Med 41:1392-403. 2003
    ..retrospective and prospective studies have consistently found an independent relationship between mild hyperhomocysteinemia and cardiovascular disease or all-cause mortality...
  44. ncbi Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease
    Leonie G Mikael
    Department of Human Genetics, Montreal Children s Hospital, Montreal, Canada
    Circ Res 98:564-71. 2006
    b>Hyperhomocysteinemia, a risk factor for cardiovascular disease, is caused by nutritional or genetic disturbances in homocysteine metabolism...
  45. pmc The treatment of hyperhomocysteinemia
    Bradley A Maron
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Med 60:39-54. 2009
    ..Numerous epidemiological reports have established hyperhomocysteinemia as an independent risk factor for cardiovascular disease, cerebrovascular disease, dementia-type disorders, ..
  46. ncbi Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study
    Johan Sundstrom
    The Framingham Heart Study, Framingham, MA, USA
    Eur Heart J 25:523-30. 2004
    ..Hyperhomocysteinaemia is a risk factor for congestive heart failure, especially in women. We investigated if homocysteine promotes left ventricular (LV) remodelling...
  47. doi Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial
    Andrew A House
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    JAMA 303:1603-9. 2010
    b>Hyperhomocysteinemia is frequently observed in patients with diabetic nephropathy. B-vitamin therapy (folic acid, vitamin B(6), and vitamin B(12)) has been shown to lower the plasma concentration of homocysteine.
  48. ncbi Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Research Center for Liver Disease and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Gastroenterology 124:1488-99. 2003
    Alcohol-induced hyperhomocysteinemia has been reported in rats and humans...
  49. ncbi High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C-->T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa
    Emile K Amouzou
    Laboratory of Cellular and Molecular Pathology in Nutrition, EMI INSERM 00 14, Vandoeuvre les Nancy, France
    Am J Clin Nutr 79:619-24. 2004
    Moderate hyperhomocysteinemia is a risk for neural tube defect and neurodegenerative and vascular diseases and has nutritional, metabolic, and genetic determinants. Its prevalence in sub-Saharan Africa remains unknown.
  50. ncbi Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Blood 103:2624-9. 2004
    Deficiency of methylenetetrahydrofolate reductase (MTHFR) predisposes to hyperhomocysteinemia and vascular disease...
  51. ncbi Public health significance of elevated homocysteine
    Jacob Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Food Nutr Bull 29:S116-25. 2008
    ..Whether this denominator is homocysteine itself or homocysteine is merely a marker, remains to be determined...
  52. doi Homocysteine induces oxidative-nitrative stress in heart of rats: prevention by folic acid
    Janaina Kolling
    Laboratório de Neuroproteção e Doenças Metabólicas, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, CEP, Porto Alegre, RS, Brazil
    Cardiovasc Toxicol 11:67-73. 2011
    b>Hyperhomocysteinemia is a risk factor for cardiovascular disease, stroke, and thrombosis; however, the mechanisms by which homocysteine triggers these dysfunctions are not fully understood...
  53. doi Dietary patterns are associated with hyperhomocysteinemia in an urban Pakistani population
    Mohsin Yakub
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan
    J Nutr 140:1261-6. 2010
    ..of the prudent dietary pattern for the highest quartile of intake compared with the lowest quartile of hyperhomocysteinemia when the model was adjusted for age, gender, household income, BMI, tobacco chewing, and smoking [OR = 0...
  54. ncbi Hyperhomocysteinemia and retinal vascular occlusive disease
    A M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Eur J Ophthalmol 12:495-500. 2002
    ..This prospective study compared plasma total homocysteine levels in patients with retinal vascular occlusive disease and in matched healthy controls...
  55. ncbi Hyperhomocysteinemia in central retinal vein occlusion in young adults
    Maurizio Battaglia Parodi
    Eye Clinic, University of Trieste, Italy
    Semin Ophthalmol 18:154-9. 2003
    Several investigators have tried to assess the role of hyperhomocysteinemia and the 677C-T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene as risk factors in retinal vein occlusion with contrasting results...
  56. ncbi Homocysteine lowering with folic acid and B vitamins in vascular disease
    Eva Lonn
    Population Health Research Institute, Hamilton General Hospital, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont
    N Engl J Med 354:1567-77. 2006
    ..Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease...
  57. pmc Maternal methyl donors supplementation during lactation prevents the hyperhomocysteinemia induced by a high-fat-sucrose intake by dams
    Paúl Cordero
    Department of Nutrition, Food Science and Physiology, University of Navarra, 31008 Pamplona, Spain
    Int J Mol Sci 14:24422-37. 2013
    ..could program offspring obesity features, while methyl donors supplementation prevented the onset of high hyperhomocysteinemia. Maternal dietary intake also affected hepatic DNA methylation metabolism, which could be linked with the ..
  58. doi Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia
    Amany K Elshorbagy
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Nutrition 26:1201-4. 2010
    ..We investigated the serum sulfur amino acid profile of male Fischer-344 rats fed a methionine-restricted diet for 3 mo...
  59. ncbi The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia
    B D Guenther
    Biophysics Research Division, University of Michigan, Ann Arbor 48109 1055, USA
    Nat Struct Biol 6:359-65. 1999
    ..Folate derivatives protect wild-type and mutant E. coli enzymes against flavin loss, and protect human MTHFR and the A222V mutant against thermal inactivation, suggesting a mechanism by which folate treatment reduces homocysteine levels...
  60. doi Chronic hyperhomocysteinemia alters antioxidant defenses and increases DNA damage in brain and blood of rats: protective effect of folic acid
    Cristiane Matte
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Int 54:7-13. 2009
    We have previously demonstrated that acute hyperhomocysteinemia induces oxidative stress in rat brain...
  61. ncbi Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion
    J Larsson
    Department of Ophthalmology, Lund University Hospital, Sweden
    Acta Ophthalmol Scand 78:340-3. 2000
    b>Hyperhomocysteinemia is a factor that predisposes to thrombosis, and the C677T mutation in methylene-tetrahydrofolate reductase (MTHFR) is known to give increased plasma homocysteine...
  62. ncbi Plasma total homocysteine, folate, and vitamin B12 status in Korean adults
    Hyeon Sook Lim
    Department of Food and Nutrition, Chonnam National University, Yongbong Dong, Buk gu Gwangju, 500 757, Korea
    J Nutr Sci Vitaminol (Tokyo) 48:290-7. 2002
    ..Thus the incidence of hyperhomocysteinemia (> or = 5 micromol/L) in males, 10.1%, was significantly higher (< 0.02) than the 2.1% in females...
  63. pmc Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies
    Priyanka Sharma
    Department of Proteomics and Structural Biology, Institute of Genomics and Integrative Biology, Delhi 110007, India
    Lipids Health Dis 5:1. 2006
    ..for polymorphism screening and analysis of mutations as well as epigenetic modifications in relation to hyperhomocysteinemia. We have identified 135 genes in 1137 abstracts that either modulate the levels of homocysteine or are ..
  64. ncbi Hyperhomocysteinemia in myelodysplastic syndromes: specific association with autoimmunity and cardiovascular disease
    A Cortelezzi
    Dipartimento di Ematologia, Ospedale Maggiore IRCCS and Dipartimento di Scienze Mediche Università degli Studi di Milano, Italy
    Leuk Lymphoma 41:147-50. 2001
    b>Hyperhomocysteinemia (HH) has been associated with cardiovascular and autoimmune diseases and oxidative cell damage. Myelodysplastic syndromes (MDS) are associated with autoimmunity (AI) and increased oxidative stress...
  65. pmc Associations between plasma homocysteine levels, aortic stiffness and wave reflection in patients with arterial hypertension, isolated office hypertension and normotensive controls
    G Vyssoulis
    Hypertension Unit, 1st Cardiology Clinic Athens University, Hippokration Hospital, Athens, Greece
    J Hum Hypertens 24:183-9. 2010
    ..302 (0.124), P=0.015; AH: beta (SE): 0.183 (0.057), P=0.001; NT: beta (SE): 0.308 (0.240), P=0.200). This study points to an independent relationship between circulating homocysteine levels, aortic compliance and wave reflection...
  66. ncbi Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study
    Johan Sundstrom
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Hypertension 42:1100-5. 2003
    ....
  67. ncbi The metabolic syndrome is not associated with homocysteinemia: the Persian Gulf Healthy Heart Study
    I Nabipour
    Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, I R Iran
    J Endocrinol Invest 32:406-10. 2009
    ....
  68. pmc Recurrent pregnancy loss in polycystic ovary syndrome: role of hyperhomocysteinemia and insulin resistance
    Pratip Chakraborty
    Department of Infertility, Institute of Reproductive Medicine, Kolkata, India
    PLoS ONE 8:e64446. 2013
    ..Among the several hypotheses, insulin resistance (IR), obesity and hyperhomocysteinemia (HHcy) play significant role/s in RPL...
  69. ncbi Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial
    B J Venn
    Department of Human Nutrition, University of Otago, Dunedin, New Zealand
    Eur J Clin Nutr 56:748-54. 2002
    ..To determine the minimum effective dose of folic acid required to appreciably increase serum folate and to produce a significant reduction in plasma total homocysteine (tHcy)...
  70. doi Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study
    Anna C Verkleij-Hagoort
    Department of Obstetrics, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Mol Genet Metab 94:112-9. 2008
    Maternal hyperhomocysteinemia is associated with congenital heart defects (CHDs) in the offspring. A low periconception vitamin B12 status is determined by genetic and lifestyle factors and causes hyperhomocysteinemia...
  71. doi Hyperhomocysteinemia exaggerates adventitial inflammation and angiotensin II-induced abdominal aortic aneurysm in mice
    Ziyi Liu
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
    Circ Res 111:1261-73. 2012
    A number of epidemiological studies have suggested an association of hyperhomocysteinemia (HHcy) and abdominal aortic aneurysm (AAA), but discrepancies exist. In addition, we lack direct evidence supporting a causal role.
  72. ncbi Folate therapy and in-stent restenosis after coronary stenting
    Helmut Lange
    Kardiologische Praxis, Klinikum Links der Weser, Heart Center, Bremen, Germany
    N Engl J Med 350:2673-81. 2004
    ..We tested the effect of a combination of folic acid, vitamin B6, and vitamin B12 (referred to as folate therapy) on the risk of angiographic restenosis after coronary-stent placement in a double-blind, multicenter trial...
  73. doi Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study
    Angel F Remacha
    Department of Hematology, Complejo Hospitalario Toledo, Hospital Virgen de la Salud, Avenida Barber 30, 45004, Toledo, Spain
    Int J Hematol 93:458-64. 2011
    This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital ..
  74. doi Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease
    Namita Mahalle
    Deenanath Mangeshkar Hospital and Research Center, Biochemistry Section, Department of Pathology, Erandawane, Pune, India
    J Cardiol 61:289-94. 2013
    Folate and vitamin B12 are essential components in the metabolism of homocysteine (Hcy). Hyperhomocysteinemia has been implicated in endothelial dysfunction and cardiovascular disease...
  75. ncbi Dietary eritadenine suppresses guanidinoacetic Acid-induced hyperhomocysteinemia in rats
    Shin ichiro Fukada
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka, Japan
    J Nutr 136:2797-802. 2006
    ..The results confirm that GAA is a useful compound to induce experimental hyperhomocysteinemia and indicate that eritadenine can effectively counteract the hyperhomocysteinemic effect of GAA.
  76. ncbi Hyperhomocysteinemia among Omani autistic children: a case-control study
    Amanat Ali
    Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Oman
    Acta Biochim Pol 58:547-51. 2011
    ..The results suggest that high fasting serum homocysteine and low folate and vitamin B(12) levels could be used as clinical biomarkers for an early diagnosis and management of ASD...
  77. ncbi Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia
    Francesca Pizzolo
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    J Am Coll Nutr 30:11-8. 2011
    ..The purpose of this study was to investigate the effects of FA supplementation on AdoMet, AdoHcy, and genomic DNA methylation in hyperhomocysteinemic subjects without end-stage renal disease...
  78. pmc Restoration of contractility in hyperhomocysteinemia by cardiac-specific deletion of NMDA-R1
    Karni S Moshal
    Dept of Physiology and Biophysics, 500 S Preston St, HSC Bldg A 1115, Univ of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 296:H887-92. 2009
    ..However, the role of cardiomyocyte NMDA-receptor 1 (R1) activation in hyperhomocysteinemia (HHCY) leading to myocyte dysfunction was not well understood...
  79. pmc Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan
    Mohsin Yakub
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    PLoS ONE 5:e11706. 2010
    High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population...
  80. ncbi Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals
    Alberto Battezzati
    Nutrition Section, Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, International Center for the Assessment of Body Composition, Universita degli Studi di Milano, Milano, Italy
    Nutr Metab Cardiovasc Dis 17:525-34. 2007
    ..It has been hypothesized that fat-free mass is an independent determinant of the circulating homocysteine and methionine concentrations...
  81. ncbi Mild hyperhomocysteinemia is an independent risk factor of arterial vascular disease
    G H Boers
    Department of General Internal Medicine, University Hospital Nijmegen, The Netherlands
    Semin Thromb Hemost 26:291-5. 2000
    Evidence of a positive association between mild hyperhomocysteinemia and arterial vascular disease has been accumulating in the last decade...
  82. doi Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hyperhomocysteinemia in rats
    Xian Yu
    Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
    Cardiovasc Drugs Ther 23:121-7. 2009
    We investigated the possible protective effect of poly (ADP-ribose) polymerase (PARP) inhibition in preventing endothelial dysfunction induced by hyperhomocysteinemia (Hhcy).
  83. pmc Homocysteine to hydrogen sulfide or hypertension
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Cell Biochem Biophys 57:49-58. 2010
    b>Hyperhomocysteinemia, an increased level of plasma homocysteine, is an independent risk factor for the development of premature arterial fibrosis with peripheral and cerebro-vascular, neurogenic and hypertensive heart disease, coronary ..
  84. pmc Mechanisms of cardiovascular remodeling in hyperhomocysteinemia
    Mesia M Steed
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Antioxid Redox Signal 15:1927-43. 2011
    ..Similar results are seen with an elevated level of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), which increases vascular thickness, elastin fragmentation, and arterial blood pressure...
  85. pmc Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions
    Richard S Beard
    Department of Biological Sciences, Idaho State University, Pocatello, ID 83209 8007, USA
    Blood 118:2007-14. 2011
    b>Hyperhomocysteinemia (HHcy) increases permeability of the blood-brain barrier, but the mechanisms are undetermined. Homocysteine (Hcy) is an agonist of the neuronal N-methyl-D-aspartate receptor (NMDAr)...
  86. ncbi Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis
    Jing Dai
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University, Beijing 100083, People s Republic of China
    Free Radic Biol Med 41:1566-77. 2006
    b>Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis...
  87. doi Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia
    M Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan
    Osteoporos Int 21:655-66. 2010
    ..cross-links and an increase in the nonenzymatic cross-link, pentosidine (Pen), in rabbits with methionine (Met)-induced hyperhomocysteinemia. Such detrimental cross-link formation in bone was ameliorated by raloxifene (RLX) treatment.
  88. ncbi Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure
    David O McGregor
    Department of Nephrology, Christchurch Hospital and School of Medicine, Private Bag 4710, Christchurch, New Zealand
    Kidney Int 61:1040-6. 2002
    Fasting and post-methionine load hyperhomocysteinemia are independent risk factors for vascular disease that are common in chronic renal failure...
  89. ncbi Subclinical protein malnutrition is a determinant of hyperhomocysteinemia
    Yves Ingenbleek
    Laboratories of Nutrition Faculty of Pharmacy, University Louis Pasteur Strasbourg, Illkirch, France
    Nutrition 18:40-6. 2002
    b>Hyperhomocysteinemia is regarded as a public health problem of increasing importance likely to contribute to vascular disorders and premature mortality...
  90. doi Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats
    Lamia Raaf
    Univ Paris Diderot CNRS EAC 4413, unité de Biologie Fonctionnelle et Adaptative, Case 7104, 75205, Paris Cedex 13, France
    Mol Cell Biochem 347:63-70. 2011
    b>Hyperhomocysteinemia, characterized by an elevated plasma homocysteine concentration, leads to several clinical manifestations and particularly cardiovascular diseases...
  91. ncbi ADMA and hyperhomocysteinemia
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Vasc Med 10:S27-33. 2005
    b>Hyperhomocysteinemia is a risk factor for cardiovascular disease and stroke...
  92. pmc Cardiac specific deletion of N-methyl-d-aspartate receptor 1 ameliorates mtMMP-9 mediated autophagy/mitophagy in hyperhomocysteinemia
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    J Recept Signal Transduct Res 30:78-87. 2010
    ..This led to mitophagy, in part, by activating NMDA-R1. The findings of this study will lead to therapeutic ramifications for mitigating cardiovascular diseases by inhibiting the mitochondrial mitophagy and NMDA-R1 receptor...
  93. ncbi [Steatosis, chronic hepatitis virus C infection and homocysteine]
    Xavier Roblin
    Département d Hépato Gastroentérologie, CHU Michallon, Grenoble, France
    Gastroenterol Clin Biol 31:415-20. 2007
    ..b>Hyperhomocysteinemia is frequent in the Caucasian population (more than 15%) and its role in vascular pathology has been clearly ..
  94. ncbi Cardiovascular pathogenesis in hyperhomocysteinemia
    Tao Huang
    Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Rd, Hangzhou, Zhejiang, 310029, P R China
    Asia Pac J Clin Nutr 17:8-16. 2008
    ..diseases and the molecular mechanisms and pathophysiology involved in the deleterious manifestations of hyperhomocysteinemia. We have collected data from MEDLINE, Current Contents and scientific journals, which included 112 ..
  95. ncbi Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats
    Vathsala E R Edirimanne
    Department of Animal Science, University of Manitoba, Canadian Centre for Agri Food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 85:1236-47. 2007
    Elevation of blood homocysteine (Hcy) levels (hyperhomocysteinemia) is a risk factor for cardiovascular disorders. We previously reported that oxidative stress contributed to Hcy-induced inflammatory response in vascular cells...
  96. ncbi Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats
    Saleh C El-Saleh
    Department of Medical Microbiology, College of Sciences, King Saud University, P O Box 237, Buraidah 81999, Saudi Arabia
    Int J Cardiol 93:19-23. 2004
    Although the state of hyperhomocysteinemia (HHcy) appears to be associated with higher risks of coronary, cerebral and peripheral vascular disease as well as with a number of other clinical conditions, the underlying molecular mechanisms ..
  97. ncbi Methionine metabolism in liver diseases
    James D Finkelstein
    Am J Clin Nutr 77:1094-5. 2003
  98. ncbi Role of aminothiols as a component of the plasma antioxidant system and relevance to homocysteine-mediated vascular disease
    S J Moat
    University Division of Child Health, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, UK
    Clin Sci (Lond) 100:73-9. 2001
    ..Thus hyperhomocysteinaemia may pose an oxidative stress not only through the direct cytotoxicity of homocysteine, but also from an associated fall in plasma cysteine...
  99. pmc Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91phox gene
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Free Radic Biol Med 48:1109-17. 2010
    In this study, mice lacking the gp91(phox) gene were used to address the role of NADPH oxidase in hyperhomocysteinemia-induced podocyte injury...
  100. pmc Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine
    Richard S Beard
    Department of Biological Sciences, Idaho State University, Pocatello, ID 83209 8007, United States
    Vascul Pharmacol 56:159-67. 2012
    ..These studies dissect a pharmacological opportunity for developing new therapeutic strategies in HHcy...
  101. ncbi Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular disease
    Dan Liao
    Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    Clin Chem Lab Med 45:1652-9. 2007
    b>Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is unclear...

Research Grants66

  1. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..MEGC-PEG-rMETase as a therapeutic to target end-stage renal disease patients and other patients with hyperhomocysteinemia that do not sufficiently responded to vitamin therapy...
  2. Effect of HIV protease inhibitor on alcohol induced ER stress and liver injury.
    Cheng Ji; Fiscal Year: 2013
    ..which is a well-recognized co-factor in susceptibility to the infection and progression of HIV, induced hyperhomocysteinemia and ER stress response in the liver...
  3. Homocysteine and Angiotensin II in Renovascular Remodeling
    Utpal Sen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although it is not clear whether hyperhomocysteinemia (HHcy), an elevated plasma homocysteine (Hcy) level, causes hypertension, recent clinical data suggest an association between systolic hypertension ..
  4. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..Elevated blood concentration of homocysteine (hyperhomocysteinemia;HHcy) is a risk factor for several cardiovascular diseases...
  5. METABOLIC REGULATION IN THE ACUTE PHASE
    HYUNG D RYOO; Fiscal Year: 2010
    ..in diseases and pathological states associated with ER stress such as diabetes mellitus, ischemia and hyperhomocysteinemia. Tools to manipulate cells'secretory capacity may be used to enhance production of recombinant ..
  6. Role of homocysteine in retinal disease
    Sylvia B Smith; Fiscal Year: 2013
    ..by applicant): The goal of this project is to determine how elevated levels of homocysteine (Hcy) (hyperhomocysteinemia, HHcy)) contribute to retinal neurovascular disease...
  7. Redox Triggering of Glomerular NALP3 Inflammasomes in Hyperhomocysteinemia
    Justine M Abais; Fiscal Year: 2013
    ..is to clarify the mechanisms underlying end-stage renal disease that occurs as a result from aging and hyperhomocysteinemia (hHcys)...
  8. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    Steven R Lentz; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hyperhomocysteinemia and hypercholesterolemia are common cardiovascular risk factors that often occur together in patients with vascular thrombotic events...
  9. Homocysteine, Adiponectin, and Alcoholic Liver Disease
    Zhenyuan Song; Fiscal Year: 2013
    ..Abnormal hepatic methionine/homocysteine metabolism and hyperhomocysteinemia induced by prolonged alcohol exposure has been reported both in clinical and experimental studies, however, ..
  10. Exercise and H2S mitigate homocysteine-mediated beta2-adrenergic receptor dysfunc
    Paras Kumar Mishra; Fiscal Year: 2013
    ..Elevated level of homocysteine (Hcy) called hyperhomocysteinemia (HHcy, a co-morbid condition) is associated with heart failure in diabetes...
  11. Hyperhomocysteinemia, S-adenosylhomocysteine Accumulation, and Epigenetics
    Warren D Kruger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Elevated levels of plasma total homocysteine (tHcy), termed hyperhomocysteinemia (HHcy), are associated prospectively with increased incidence and mortality of many human diseases including coronary ..
  12. Homocysteine: Vascular Biochemistry and Metabolism
    DONALD WELDON JACOBSEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hyperhomocysteinemia is a modifiable, independent risk factor for cardiovascular disease, cognitive dysfunction, complications of pregnancy, and osteoporosis...
  13. Atherogenic Mechanisms Associated with Hyperhomocysteinemia
    Hong Wang; Fiscal Year: 2013
    ..objective of this competitive renewal application is to determine the molecular mechanisms responsible for Hyperhomocysteinemia (HHcy)-accelerated atherosclerosis...
  14. Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate
    MARY VELESCA GAMBLE; Fiscal Year: 2013
    ..Our 2nd aim will examine whether polymorphisms in one-carbon metabolism candidate genes are associated with hyperhomocysteinemia (which is very common in this population, and is associated with reduced capacity to methylate As to DMA), ..
  15. Hyperhomocysteinemia and HDL Metabolism
    Hong Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hyperhomocysteinemia (HHcy) is an important non-lipid risk factor for cardiovascular disease (CVD)...
  16. Homocysteine, ER Stress and Alcoholic Liver Injury.
    Neil Kaplowitz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have demonstrated that the intragastric alcohol fed mouse develops hyperhomocysteinemia, ER stress and steatohepatitis. Feeding betaine prevents all of these effects of alcohol...
  17. Stable isotope evaluation of the methionine cycle in undernourished pregnancy
    Peter W Nathanielsz; Fiscal Year: 2013
    ..In MNR, fetal vitamin B12 is decreased 22% while folate is unchanged. Rat studies show hyperhomocysteinemia is associated with increases in both plasma HCYS inflow and outflow...
  18. Studies on Serial Phlebotomy in Voluntary Blood Donors
    Stuart D Katz; Fiscal Year: 2013
    ..a non-invasive measure of vascular endothelial function) in the basal state and in response to transient hyperhomocysteinemia, serum and urinary measures of iron stores and oxidative stress, red cell and plasma volume, regional ..
  19. HHcy-induced Bax upregulation, Treg apoptosis and vascular disease
    Xiao Feng Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Elevated level of plasma homocysteine (Hcy), termed hyperhomocysteinemia (HHcy), is an independent risk factor for human coronary heart disease (CHD) and stroke...
  20. Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque Formation
    Suresh C Tyagi; Fiscal Year: 2013
    ..Although a strong association between Ab, fibrinogen (Fg), and elevated level of homocysteine (Hcy), i.e. hyperhomocysteinemia (HHcy) during AD is well- documented, the mechanism of amyloid plaque formation is unclear...
  21. Carbon monoxide and vascular cell function
    William Durante; Fiscal Year: 2013
    ..role in promoting EC growth following arterial injury and that CO reverses endothelial dysfunction in hyperhomocysteinemia and diabetes. We further propose that CO mediates these effects via the activation of eNOS...
  22. Cerebral Vascular Biology Program Project Grant
    Frank M Faraci; Fiscal Year: 2012
    ..Modern molecular and mechanistic approaches will be used to examine effects of aging, hypertension, and hyperhomocysteinemia on cerebral blood vessels...
  23. 5Lipoxygenase-mediated vasculopathy in HHcy
    Domenico Pratico; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Elevated levels of total plasma homocysteine (Hcy), termed hyperhomocysteinemia (HHcy), are associated with increased incidence and mortality of chronic vascular diseases including coronary heart ..
  24. Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arenic
    MARY VELESCA GAMBLE; Fiscal Year: 2013
    ..The results indicate that folate deficiency and hyperhomocysteinemia (HHcys) are associated with a reduced capacity to methylate As and are risk factors for As-induced skin ..
  25. Folic Acid Vitamin B12 and One Carbon Metabolism
    CHARLES HOPKINSON HALSTED; Fiscal Year: 2010
    ..folate and vitamin B12 transport, fetal development and birth defects, one- carbon metabolism and cancer, hyperhomocysteinemia and mechanisms of disease, one carbon metabolism and cognitive disorders, folate and physiologic distress, ..
  26. Role of HHcy in diabetic vascular disease
    Hong Wang; Fiscal Year: 2010
    ..b>Hyperhomocysteinemia (hHcy), elevated plasma concentrations of Hcy, has been established as an independent and significant risk ..
  27. Hypertension and Glomerular Injury in Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Over the last four years, we have demonstrated that hyperhomocysteinemia (hHcys) contributes to the development of glomerular sclerosis associated with hypertension...
  28. NADHP Oxidase-mediated MC differentiation &Endothelial Dysfunction in HHcy
    Hong Wang; Fiscal Year: 2013
    ..objective of new application is to determine the role and mechanism of NADPH-related oxidative stress in Hyperhomocysteinemia (HHcy)-caused monocyte differentiation and endothelial dysfunction...
  29. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..reductase (MTRR) 66A yields G polymorphism, betaine-homocysteine methyltransferase (BHMT) mutation and hyperhomocysteinemia. We will also test for acquired (and perhaps transitory) coagulation abnormalities such as lupus ..
  30. Homocysteine's role in the causation of presbyopia
    CHARLES PRINCE; Fiscal Year: 2002
    ..It is clear from the set of pathologies that occurs in this disorder that severe hyperhomocysteinemia has significant detrimental effects on connective tissues- the most commonly observed pathological changes ..
  31. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..Relative vitamin deficiencies, especially that of B6, B12 and folate, also occur. Hyperhomocysteinemia (hyperHcy), a novel cardio-vascular and thrombotic risk factor, is at least partly correctable with folate ..
  32. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..many patients have elevations in homocysteine levels only after a methionine load, and both fasting and PML hyperhomocysteinemia may be associated with dementia, we will determine whether fasting hyperhomocysteinemia, PML ..
  33. ALTERED METHIONINE METABOLISM IN ALCOHOLIC LIVER INJURY
    Shelly Lu; Fiscal Year: 2005
    DESCRIPTION: (Adapted from the Applicant's Abstract): Altered hepatic methionine metabolism and hyperhomocysteinemia are well recognized in alcoholic liver disease but the exact mechanisms and pathogenetic consequences are not well ..
  34. ADVANCED EPR STUDIES OF B12 DEPENDENT ENZYMES
    GARY GERFEN; Fiscal Year: 2005
    ..from abstract): Diseases in humans that are caused by deficiencies or malabsorption of vitamin B12 include hyperhomocysteinemia, megaloblastic anemia, pernicious anemia and methylmalonic acidemia...
  35. Selenium, Glutathione Peroxidase-1, and Homocysteine-induced Cardiac Remodeling
    Jacob Joseph; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hyperhomocysteinemia (Hhe) is an independent risk factor for both systolic and diastolic heart failure...
  36. The assessment of hydrogen sulfide in vascular biology
    David Kraus; Fiscal Year: 2006
    ..The vascular dysfunction in hyperhomocysteinemia may be a result of decreased H2S levels...
  37. HOMOCYSTEINE MODIFIES BONE MATRIX AND MINERALIZATION
    CHARLES PRINCE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): We hypothesized several years ago that moderate levels of hyperhomocysteinemia may have a causal role in a number of connective tissue pathologies typically thought of as normal ..
  38. GENETIC HETEROGENEITY IN HOMOCYSTEINE REMETHYLATION
    Barry Shane; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract) Chronic mild hyperhomocysteinemia has been implicated as a risk factor for occlusive vascular disease and genetic variation in folate metabolism has been implicated in the development of ..
  39. HYPERHOMOCYSTEINEMIA IN PREGNANCY AND PREECLAMPSIA
    James Roberts; Fiscal Year: 2001
    ..b>Hyperhomocysteinemia is a risk factor for atherosclerosis and recent data also indicate increased prevalence of ..
  40. GENETIC RISK FACTORS FOR HYPERHOMOCYSTEINEMIA
    ROY GRAVEL; Fiscal Year: 2006
    ..In summary, our study will give a biochemical and physiological face to the impact of 122M on enzyme function, development and disease. ..
  41. ARGINASE AND ARTERIAL INJURY
    William Durante; Fiscal Year: 2009
    ..In aim 3, the regulation and role of arginase I in hyperhomocysteinemia will be investigated using cultured SMC and genetic and dietary animal models of hyperhomocysteinemia...
  42. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2005
    ..We propose that the H475Y allele reduces folate absorption resulting in lower folate levels and hyperhomocysteinemia, while both H475Y and GCP-18 variants modulate the expression of GCPII in the intestine...
  43. R-HOMOCYSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 1999
    ..PROPOSED COMMERCIAL APPLICATIONS: Hyperhomocysteinemia and hyperhomocysteinuria are strong risk factors for cardiovascular disease...
  44. HOMOCYSTEINE, BETA-OXIDATION AND RISK OF PREECLAMPSIA
    Robert Powers; Fiscal Year: 2002
    ..We hypothesize that: 1) Hyperhomocysteinemia predisposes toward decreased beta-oxidation, and this effect will be exacerbated in pregnancy and 2) ..
  45. Renal Transplantation, Homocysteine Lowering & Cognition
    Irwin Rosenberg; Fiscal Year: 2007
    ..b>Hyperhomocysteinemia is a pervasive feature of chronic renal insufficiency, even after a successful transplant; however, unlike ..
  46. Epidemiology of Venous Thromboembolism
    Robert Glynn; Fiscal Year: 2004
    ..and genetic markers of risk including factor V Leiden, the G20210A mutation in the prothrombin gene, hyperhomocysteinemia, and anticardiolipin antibodies...
  47. FOLIC ACID AND HOMOCYSTEINE: MECHANISMS OF HEART DEFECTS
    Thomas Rosenquist; Fiscal Year: 2005
    ..objective of this program is to determine the biological mechanisms whereby folic acid insufficiency and hyperhomocysteinemia may contribute to abnormal development of the heart...
  48. NUTRIENT REGULATION OF BHMT EXPRESSION
    Timothy Garrow; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Hyperhomocysteinemia is reportedly a prevalent, independent and graded risk factor for all major forms of vascular disease and thrombosis, and more recently it has been associated with neural tube ..
  49. GENETIC CONTROL OF HOMOCYSTEINE METABOLISM IN MICE
    Joseph Nadeau; Fiscal Year: 2000
    ..The PI has requested 3 years of support to investigate the genetic basis of hyperhomocysteinemia and its relationship to vascular pathology in several inbred strains of mice...
  50. MOLECULAR STUDIES OF FOLATE HOMEOSTASIS
    Charles Halsted; Fiscal Year: 2000
    ..Folate deficiency results in anemia, functional abnormalities of the small intestine, and hyperhomocysteinemia with increased risk of vascular disease...
  51. FASEB Summer Conference: Folate, B12 and 1C Metabolism
    PATRICK STOVER; Fiscal Year: 2004
    ..from clinical trials, (2) The clinical utility of holoTC as an early marker of vitamin B12 deficiency, (3) Hyperhomocysteinemia and cognitive dysfunction and (4) Pharmacogenomics...
  52. CORONARY CALCIFICATIONS IN RENAL TRANSPLANT RECIPIENTS
    Sylvia Rosas; Fiscal Year: 2003
    ..to date exhibit a high prevalence of adverse lipid profiles, elevated levels of lipoprotein (a) (Lp(a)) and hyperhomocysteinemia. However, long observation periods are required to assess the effect of this risk factors in RTR...
  53. Magnetic Resonance Microimaging System
    Joel Morrisett; Fiscal Year: 2005
    ..2) Dynamic measurement of mouse heart structure and function, 3) Atherogenic mechanisms associated with hyperhomocysteinemia, 4) Murine skeletal, cardiac, and smooth muscle differentiation, 5) Role of acetyI-CoA carboxylases in fat ..
  54. DNA Hypomethylation in Athersclerosis in PTS with ESRD
    Josephine Chiu; Fiscal Year: 2003
    ..Vitamin B deficiency and resistant hyperhomocysteinemia may contribute to the increase in cardiovascular disease mortality, as well as the reduction of patients' ..
  55. HEAT SHOCK IN VASCULAR SMOOTH MUSCLE CELLS
    ARNOLD BAAS; Fiscal Year: 2003
    ..factors for atherosclerosis such as hyperlipidemia, diabetes mellitus, cigarette smoking, hypertension, and hyperhomocysteinemia cause oxidative stress and have been demonstrated to change vessel redox state...
  56. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Elevated levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy) are associated with cardiac arrhythmia and sudden cardiac death (SCO)...
  57. Mechanism of Vascular Remodeling in Hyperhomocysteinemia
    Suresh C Tyagi; Fiscal Year: 2010
    Elevated plasma levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy) cause vascular disease. The long-term objective of this project is to understand the mechanism of vascular remodeling in HHcy...
  58. Folate, DNA Methylation and Breast Tumorigenesis
    Joshua Miller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  59. B12 Absorption, Kinetics and Transcobalamin Genotype
    Joshua Miller; Fiscal Year: 2004
    ..This novel method would ultimately replace the Schilling test, the current gold standard, but flawed and cumbersome method for clinical assessment of B 12 absorptive capacity. ..
  60. B12 Nutrition in the Aged
    Sally Stabler; Fiscal Year: 2007
    b>Hyperhomocysteinemia (high serum total homocysteine) remains a problem for seniors even in this era of highly folate-fortified food in the United States...
  61. Homocysteine and Alcoholic Liver Disease
    DONALD WELDON JACOBSEN; Fiscal Year: 2010
    ..Elevated blood homocysteine (hyperhomocysteinemia) is strongly associated with chronic alcoholism...
  62. Role of 10-formyldihydrofolate in purine biosynthesis
    Tsunenobu Tamura; Fiscal Year: 2004
    ..If this pathway is proven, derivatives of 10-HCO-H2folate could be used to inhibit de novo purine biosynthesis for developing new anticancer drugs. ..
  63. Vitamin B12 Status of Elderly Americans
    MARTHA MORRIS; Fiscal Year: 2003
    ..The third aim is to evaluate the usefulness of a serum vitamin B12 cut-off point of 258 pmol/L, either as the sole indicator of vitamin B12 deficiency in the elderly, or in conjunction with anemia or an elevated metabolite level. ..
  64. Effect of Statins on Pathobiology of Alzheimer's Disease
    Cynthia Carlsson; Fiscal Year: 2008
    ..Cognitive testing will also be repeated at the 3-month follow-up. Outcome measures at 9 months will be compared to baseline. Results will be analyzed by apolipoprotein E4 status. ..
  65. Flavocoxid: A Medical Food Therapy for Osteoarthritis
    Sarah Morgan; Fiscal Year: 2004
    ..This innovative compound has commercial potential with its expected efficacy comparable to or exceeding the currently marketed COX inhibitors but with fewer side effects and at a significantly lower cost. ..
  66. Vascular Biochemistry of Vitamin B12
    DONALD JACOBSEN; Fiscal Year: 2006
    ..b>Hyperhomocysteinemia is a major independent risk factor for cardiovascular disease and is also associated with other devastating ..