anaplasmosis

Summary

Summary: A disease of cattle caused by parasitization of the red blood cells by bacteria of the genus ANAPLASMA.

Top Publications

  1. ncbi Nosocomial transmission of human granulocytic anaplasmosis in China
    Lijuan Zhang
    National Institute of Communicable Disease Control and Prevention, China, CDC, Beijing, China, PO Box 5, Changping, Beijing, China 102206
    JAMA 300:2263-70. 2008
  2. ncbi Borrelia miyamotoi infection presenting as human granulocytic anaplasmosis: a case report
    Hanumara Ram Chowdri
    Hawthorn Medical Associates and St Luke s Hospital, New Bedford, Massachusetts, USA
    Ann Intern Med 159:21-7. 2013
  3. ncbi The natural history of Anaplasma marginale
    Katherine M Kocan
    Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK 74078 2007, USA
    Vet Parasitol 167:95-107. 2010
  4. ncbi Human anaplasmosis in Belgium: a 10-year seroepidemiological study
    Christel Cochez
    Research Laboratory and Reference Laboratory for Vector borne Diseases, Queen Astrid Military Hospital, B 1120 Brussels, Belgium
    Ticks Tick Borne Dis 2:156-9. 2011
  5. pmc Human ehrlichiosis and anaplasmosis
    Nahed Ismail
    Department of Pathology, Meharry Medical College, Nashville, TN 37208, USA
    Clin Lab Med 30:261-92. 2010
  6. ncbi Anaplasmosis in dogs: the relation of haematological, biochemical and clinical alterations to antibody titre and PCR confirmed infection
    Urska Ravnik
    Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Cesta v Mestni log 47, SI 1000 Ljubljana, Slovenia
    Vet Microbiol 149:172-6. 2011
  7. ncbi Ehrlichiosis and anaplasmosis in dogs and cats
    Susan E Little
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078 2007, USA
    Vet Clin North Am Small Anim Pract 40:1121-40. 2010
  8. pmc Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies
    Patrick J Kelly
    Ross University School of Veterinary Medicine, St Kitts, West Indies
    PLoS ONE 8:e53450. 2013
  9. ncbi Emerging perspectives in the research of bovine babesiosis and anaplasmosis
    Carlos E Suarez
    Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture, Pullman, WA 99164 6630, USA
    Vet Parasitol 180:109-25. 2011
  10. ncbi Anaplasma phagocytophilum in ruminants in Europe
    Zerai Woldehiwet
    Veterinary Teaching Hospital, Leahurst, Neston, South Wirral, UK
    Ann N Y Acad Sci 1078:446-60. 2006

Detail Information

Publications237 found, 100 shown here

  1. ncbi Nosocomial transmission of human granulocytic anaplasmosis in China
    Lijuan Zhang
    National Institute of Communicable Disease Control and Prevention, China, CDC, Beijing, China, PO Box 5, Changping, Beijing, China 102206
    JAMA 300:2263-70. 2008
    Human granulocytic anaplasmosis (HGA) is an emerging tick-borne disease in China...
  2. ncbi Borrelia miyamotoi infection presenting as human granulocytic anaplasmosis: a case report
    Hanumara Ram Chowdri
    Hawthorn Medical Associates and St Luke s Hospital, New Bedford, Massachusetts, USA
    Ann Intern Med 159:21-7. 2013
    ..diseases, patients presenting with acute febrile illness with myalgia, headache, neutropenia, thrombocytopenia, and elevated hepatic aminotransferase levels are presumptively diagnosed as having human granulocytic anaplasmosis (HGA).
  3. ncbi The natural history of Anaplasma marginale
    Katherine M Kocan
    Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK 74078 2007, USA
    Vet Parasitol 167:95-107. 2010
    ..Infection of cattle with A. marginale causes bovine anaplasmosis, a mild to severe hemolytic disease that results in considerable economic loss to both dairy and beef ..
  4. ncbi Human anaplasmosis in Belgium: a 10-year seroepidemiological study
    Christel Cochez
    Research Laboratory and Reference Laboratory for Vector borne Diseases, Queen Astrid Military Hospital, B 1120 Brussels, Belgium
    Ticks Tick Borne Dis 2:156-9. 2011
    Human granulocytic anaplasmosis (HGA) is a tick-borne rickettsial infection of neutrophils caused by Anaplasma phagocytophilum...
  5. pmc Human ehrlichiosis and anaplasmosis
    Nahed Ismail
    Department of Pathology, Meharry Medical College, Nashville, TN 37208, USA
    Clin Lab Med 30:261-92. 2010
    Human ehrlichiosis and anaplasmosis are acute febrile tick-borne diseases caused by various members of the genera Ehrlichia and Anaplasma (Anaplasmataceae)...
  6. ncbi Anaplasmosis in dogs: the relation of haematological, biochemical and clinical alterations to antibody titre and PCR confirmed infection
    Urska Ravnik
    Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Cesta v Mestni log 47, SI 1000 Ljubljana, Slovenia
    Vet Microbiol 149:172-6. 2011
    ..phagocytophilum in a particular patient...
  7. ncbi Ehrlichiosis and anaplasmosis in dogs and cats
    Susan E Little
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078 2007, USA
    Vet Clin North Am Small Anim Pract 40:1121-40. 2010
    ..been made in our understanding of the diversity of the rickettsial organisms responsible for ehrlichiosis and anaplasmosis in dogs and, occasionally, cats, the vectors capable of transmitting these agents, and the role these organisms ..
  8. pmc Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies
    Patrick J Kelly
    Ross University School of Veterinary Medicine, St Kitts, West Indies
    PLoS ONE 8:e53450. 2013
    ..Although tick-borne diseases are important causes of morbidity and mortality in dogs in tropical areas, there is little information on the agents causing these infections in the Caribbean...
  9. ncbi Emerging perspectives in the research of bovine babesiosis and anaplasmosis
    Carlos E Suarez
    Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture, Pullman, WA 99164 6630, USA
    Vet Parasitol 180:109-25. 2011
    ..In addition, acute babesiosis and anaplasmosis can be prevented quite effectively by combining tick control and vaccination with living attenuated organisms...
  10. ncbi Anaplasma phagocytophilum in ruminants in Europe
    Zerai Woldehiwet
    Veterinary Teaching Hospital, Leahurst, Neston, South Wirral, UK
    Ann N Y Acad Sci 1078:446-60. 2006
    ..More recently, a few cases of human granulocytic anaplasmosis (HGA) have been reported in some European countries, but it remains to be established whether the variants ..
  11. ncbi Epidemiology and control of human granulocytic anaplasmosis: a systematic review
    Hongtao Jin
    Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, Jilin Province, People s Republic of China
    Vector Borne Zoonotic Dis 12:269-74. 2012
    Granulocytic anaplasmosis caused by Anaplasma phagocytophilum is an emerging tick-borne zoonosis worldwide...
  12. ncbi Comparative strain analysis of Anaplasma phagocytophilum infection and clinical outcomes in a canine model of granulocytic anaplasmosis
    Diana G Scorpio
    Department of Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Vector Borne Zoonotic Dis 11:223-9. 2011
    ..clinical disease in experimentally inoculated dogs similar to dogs with naturally acquired granulocytic anaplasmosis. Six hounds were inoculated intravenously with one human and two canine strains of A...
  13. pmc Functional epitope core motif of the Anaplasma marginale major surface protein 1a and its incorporation onto bioelectrodes for antibody detection
    Paula S Santos
    Laboratório de Nanobiotecnologia, Instituto de Genética e Bioquímica, Universidade Federal de Uberlandia, Uberlandia, Brazil
    PLoS ONE 7:e33045. 2012
    b>Anaplasmosis, a persistent intraerythrocytic infection of cattle by Anaplasma marginale, causes severe anemia and a higher rate of abortion, resulting in significant loss to both dairy and beef industries...
  14. ncbi Epidemiological analysis of tick-borne diseases in Zambia
    Martin Simuunza
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Vet Parasitol 175:331-42. 2011
    ..bovis), anaplasmosis (caused by Anaplasma marginale) and heartwater (caused by Ehrlichia ruminantium)...
  15. ncbi Application of a reverse line blot assay to the study of haemoparasites in cattle in Uganda
    C A L Oura
    Department of Microbiology and Parasitology, Faculty of Vet Medicine, Makerere University, Kampala, Uganda
    Int J Parasitol 34:603-13. 2004
    ..mutans and possibly T. taurotragi and T. velifera, may also cause clinical disease. Overall, the results presented here highlight the complexity of tick-borne pathogen infections in cattle in Uganda...
  16. ncbi Detection of haemoparasites in cattle by reverse line blot hybridisation with a note on the distribution of ticks in Sicily
    K Georges
    Division of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.165, 3508 TD Utrecht, The Netherlands
    Vet Parasitol 99:273-86. 2001
    ..lusitanicum, Rhipicephalus sanguineus group, R. bursa, Dermacentor marginatus, Haemaphysalis punctata, B. annulatus and I. ricinus...
  17. ncbi Epidemiological, clinical and laboratory characteristics of patients with human granulocytic anaplasmosis in Slovenia
    Stanka Lotric-Furlan
    Department of Infectious Diseases, University Medical Center Ljubljana, University of Ljubljana, Slovenia
    Wien Klin Wochenschr 118:708-13. 2006
    Human granulocytic anaplasmosis (HGA) has been recently recognized as an emerging tick-borne disease. Several reports indicate the presence of infection with Anaplasma phagocytophilum in Europe...
  18. pmc Competitive exclusion between piroplasmosis and anaplasmosis agents within cattle
    Loubna Dib
    Institut Vétérinaire, Centre Universitaire El Tarf, Route de Matroha, El Tarf, Algeria
    PLoS Pathog 4:e7. 2008
  19. ncbi Canine granulocytic anaplasmosis: a review
    D D Carrade
    Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Vet Intern Med 23:1129-41. 2009
    ..phagocytophilum occurs after natural infection requires additional study, with most reports suggesting that anaplasmosis is a self-limiting disease in dogs that responds well to a 2-week course of doxycycline therapy.
  20. ncbi Relative efficiency of biological transmission of Anaplasma marginale (Rickettsiales: Anaplasmataceae) by Dermacentor andersoni (Acari: Ixodidae) compared with mechanical transmission by Stomoxys calcitrans (Diptera: Muscidae)
    Glen A Scoles
    USDA ARS, Animal Disease Research Unit, Washington State University, Pullman, WA 99164, USA
    J Med Entomol 42:668-75. 2005
    ....
  21. ncbi Anaplasma phagocytophilum - the most widespread tick-borne infection in animals in Europe
    S Stuen
    Department of Production Animal Clinical Sciences, Norwegian School of Veterinary Science, Sandnes, Norway
    Vet Res Commun 31:79-84. 2007
    ..Based on the 16S rRNA gene sequences several variants exist. Different variants may exist within the same herd and even simultaneously in the same animal. Variants may behave differently and interact in the mammalian host...
  22. pmc CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis
    Diana G Scorpio
    Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 11:963-8. 2004
    ..phagocytophilum is an obligate intracellular bacterium that infects neutrophils and causes human granulocytic anaplasmosis. Infection induces neutrophil secretion of interleukin-8 or murine homologs and perpetuates infection by ..
  23. ncbi Epidemiology of human ehrlichiosis and anaplasmosis in the United States, 2001-2002
    Linda J Demma
    Viral and Rickettsial Zoonoses Branch and Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 73:400-9. 2005
    ..through 2002, 1,176 cases of the tick-borne diseases human monocytic ehrlichiosis (HME) and human granulocytic anaplasmosis (HGA) were reported to the Centers for Disease Control and Prevention (CDC) by 32 states through the National ..
  24. ncbi Temporal patterns of tick-borne granulocytic anaplasmosis in California
    Daniel Rejmanek
    School of Veterinary Medicine, Dept of Medicine and Epidemiology, University of California, Davis, CA 95616, USA
    Ticks Tick Borne Dis 2:81-7. 2011
    Granulocytic anaplasmosis (GA) is a tick-borne emerging infectious disease caused by the bacterium Anaplasma phagocytophilum. From fall 2005 to spring 2007, A...
  25. ncbi Epidemiology of bovine tick-borne diseases in southern Italy
    Giuseppe Cringoli
    Dipartimento di Patologia e Sanita Animale, Universita degli Studi di Napoli Federico II, Italy
    Vet Res 33:421-8. 2002
    ..6) and Haemaphysalis punctata (8.4). The results showed that B. bigemina, A. marginale and their potential vectors are common in the area examined and indicated that there is a risk for animals imported from tick-borne disease-free areas...
  26. ncbi Induced immune response of DNA vaccine encoding an association MSP1a, MSP1b, and MSP5 antigens of Anaplasma marginale
    Flora S Kano
    Protozoology Laboratory, Departamento de Medicina Veterinaria Preventiva, CCA, Universidade de Londrina UEL, Londrina, Parana state, Brazil
    Vaccine 26:3522-7. 2008
    ..proteins of Anaplasma marginale have been the focus of research to obtain an improved vaccine against bovine anaplasmosis. We evaluated the capacity of the recombinant plasmids pcDNA-msp1alpha, pcDNA-msp1beta, and pcDNA-mp5 to ..
  27. ncbi Investigation of anaplasmosis in Yiyuan County, Shandong Province, China
    Lijuan Zhang
    Department of Rickettsiology and Anaplasmosis, National Institute of Communicable Disease Control and Prevention, China CDC, Beijing 102206, China
    Asian Pac J Trop Med 4:568-72. 2011
    To investigate the situation of anaplasmosis in Yiyuan county, Shandong Province.
  28. ncbi Fatal bovine anaplasmosis in a herd with new genotypes of Anaplasma marginale, Anaplasma ovis and concurrent haemoplasmosis
    S Hornok
    Department of Parasitology and Zoology, Szent Istvan University, Budapest, Hungary
    Res Vet Sci 92:30-5. 2012
    Haematological and molecular analysis of blood samples was carried out during an outbreak of bovine anaplasmosis in Hungary. Acute disease was observed in five animals, two of which died...
  29. ncbi Etiological [corrected] agents of rickettsiosis and anaplasmosis in ticks collected in Emilia-Romagna region (Italy) during 2008 and 2009
    Giulia Maioli
    Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna, Sezione di Reggio Emilia, via Pitagora n 2, 42100 Reggio Emilia, Italy
    Exp Appl Acarol 57:199-208. 2012
    ..5 and 1.5%, respectively). Our results highlight that that ticks present in wild areas, widely exploited for recreation and hunting in Emilia-Romagna, represent a risk for the transmission of spotted fevers and anaplasmosis to humans.
  30. pmc First case of Anaplasma platys infection in a dog from Croatia
    Viktor Dyachenko
    Institute for Infectious Diseases and Zoonoses, Department for Veterinary Sciences, Faculty for Veterinary Medicine, LMU Munich, Veterinarstrasse 13, 80539 Munich, Germany
    Parasit Vectors 5:49. 2012
    ..Diagnostic tests were performed to identify infections caused by Anaplasma spp., Ehrlichia spp., Hepatozoon canis, Babesia spp., Leishmania spp., Borrelia burgdorferi and/or Dirofilaria immitis...
  31. ncbi Anaplasmosis in two dogs in France and molecular and phylogenetic characterization of Anaplasma phagocytophilum
    Margarida Canelas Domingos
    Laboratoire Vebiotel, Arcueil, France
    Vet Clin Pathol 40:215-21. 2011
    ..phagocytophilum infecting people and animals. Three isolates of A. phagocytophilum, 1 from Spain (cow) and 2 from Norway (sheep and deer), were external to the European and American clades...
  32. pmc Experimental infection of white-tailed deer with Anaplasma phagocytophilum, etiologic agent of human granulocytic anaplasmosis
    Cynthia M Tate
    Southeastern Cooperative Wildlife Disease Study, Wildlife Health Building, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7393
    J Clin Microbiol 43:3595-601. 2005
    ..However, the susceptibility and immunologic response of WTD to A. phagocytophilum render them suitable candidates as natural sentinels for this zoonotic tick-borne organism...
  33. ncbi Characterization of the functional domain of major surface protein 1a involved in adhesion of the rickettsia Anaplasma marginale to host cells
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, 74078 2007, Stillwater, OK, USA
    Vet Microbiol 91:265-83. 2003
    ..These studies demonstrated that the tandemly repeated region of the protein mediates the adhesive function of MSP1a...
  34. ncbi Epidemiology of bovine anaplasmosis in dairy herds from Costa Rica
    J B Oliveira
    Catedra de Parasitologia, Departamento de Biologia, Universidade Federal Rural de Pernambuco UFRPE, Dom Manoel de Medeiros SN, Recife, CEP 52171 900, Pernambuco, Brazil
    Vet Parasitol 177:359-65. 2011
    Bovine anaplasmosis is endemic and occurs in almost all areas of livestock production of Costa Rica...
  35. pmc Antibody against an Anaplasma marginale MSP5 epitope common to tick and erythrocyte stages identifies persistently infected cattle
    D Knowles
    Animal Disease Research Unit, USDA Agricultural Research Service, Pullman, Washington, USA
    J Clin Microbiol 34:2225-30. 1996
    ..was established by using 261 serum samples from cattle in the regions of Hawaii and Northern Ontario where anaplasmosis is not endemic and from cattle proven by splenectomy or subinoculation of whole blood into susceptible ..
  36. ncbi Anaplasmosis control and diagnosis in South Africa
    D T De Wall
    Parasitology Division, Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort 0110, South Africa
    Ann N Y Acad Sci 916:474-83. 2000
    b>Anaplasmosis is widespread in South Africa with more than 99% of the total cattle population at risk. Five tick species have been experimentally shown to be capable of transmitting Anaplasma in South Africa...
  37. ncbi Ehrlichia platys (Anaplasma platys) in dogs from Maracaibo, Venezuela: an ultrastructural study of experimental and natural infections
    C Arraga-Alvarado
    Unidad de Investigacioned Clínicas Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela
    Vet Pathol 40:149-56. 2003
    ..Our results indicate that distinct ultrastructural characteristics are associated with different stages of A. platys development and may differ among A. platys strains...
  38. pmc Genetic variants of Anaplasma phagocytophilum from 14 equine granulocytic anaplasmosis cases
    Cornelia Silaghi
    Comparative Tropical Medicine and Parasitology, Faculty of Veterinary Medicine, Ludwig Maximilians Universitat, Leopoldstr, 5, 80802 Munich, Germany
    Parasit Vectors 4:161. 2011
    Equine Granulocytic Anaplasmosis (EGA) is caused by Anaplasma phagocytophilum, a tick-transmitted, obligate intracellular bacterium. In Europe, it is transmitted by Ixodes ricinus. A large number of genetic variants of A...
  39. pmc Agents of human anaplasmosis and Lyme disease at Camp Ripley, Minnesota
    RUSSELL C JOHNSON
    University of Minnesota, Department of Microbiology, Minneapolis, Minnesota 55455, USA
    Vector Borne Zoonotic Dis 11:1529-34. 2011
    ..Antibodies to Bb were detected in >80% of the deer, but Bb DNA was only detected in 1.5% of blood specimens...
  40. ncbi Molecular epidemiology of human and bovine anaplasmosis in southern Europe
    Victoria Naranjo
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Ann N Y Acad Sci 1078:95-9. 2006
    ..The presence of concurrent infections in cattle and deer suggests that these pathogens may multiply in the same reservoir host and illustrates the complexity of the epidemiology of bovine and human anaplasmosis in this region.
  41. ncbi The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
    Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases ..
  42. ncbi Development of enzyme-linked immunosorbent assays based on recombinant MSP1a and MSP2 of Anaplasma marginale
    Flábio R Araújo
    Embrapa Gado de Corte, Rodovia BR 262, 79002 970 Campo Grande, MS, Brazil
    Mem Inst Oswaldo Cruz 100:765-9. 2005
    ..89. The similar performances of the ELISAs suggest that both tests can be used in epidemiological surveys for detection of antibodies to A. marginale in cattle...
  43. ncbi Immunity following use of Australian tick fever vaccine: a review of the evidence
    R E Bock
    Tick Fever Research Centre, Animal and Plant Health Service, Queensland Department of Primary Industries, Wacol
    Aust Vet J 79:832-9. 2001
    ..To review the evidence available on the degree and duration of immunity provided by Australian tick fever vaccines against Babesia bovis, B. bigemina and Anaplasma marginale infections in Australia and overseas...
  44. pmc Immunogenicity of Anaplasma marginale type IV secretion system proteins in a protective outer membrane vaccine
    Job E Lopez
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 75:2333-42. 2007
    ..marginale and related pathogens...
  45. ncbi Anaplasmosis control. Past, present, and future
    K M Kocan
    Department of Anatomy, Pathology and Pharmacology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Ann N Y Acad Sci 916:501-9. 2000
    Control methods for anaplasmosis have not changed markedly during the past 50 years and include arthropod control, chemoprophylaxsis, vaccination, and maintenance of an Anaplasma-free herd...
  46. ncbi Possible differential host tropism in Anaplasma phagocytophilum strains in the Western United States
    Janet Foley
    School of Veterinary Medicine, Department of Medicine and Epidemiology, University of California, Davis, Davis California, USA
    Ann N Y Acad Sci 1149:94-7. 2008
    ..phagocytophilum strains and further research to understand the host-pathogen interactions that result in differential outcomes in infection...
  47. pmc Diagnosis of canine vector-borne diseases in young dogs: a longitudinal study
    Domenico Otranto
    Department of Veterinary Public Health and Animal Sciences, Faculty of Veterinary Medicine, Valenzano, Bari, Italy
    J Clin Microbiol 48:3316-24. 2010
    ....
  48. ncbi Differential adhesion of major surface proteins 1a and 1b of the ehrlichial cattle pathogen Anaplasma marginale to bovine erythrocytes and tick cells
    J de la Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    Int J Parasitol 31:145-53. 2001
    ..marginale adhesin for both bovine erythrocytes and tick cells while MSP1b is an adhesin only for bovine erythrocytes. The role of the MSP1 complex, therefore, appears to vary among vertebrate and invertebrate hosts...
  49. ncbi Detection of Anaplasma platys and Babesia canis vogeli and their impact on platelet numbers in free-roaming dogs associated with remote Aboriginal communities in Australia
    G K Brown
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan NSW 2308, Australia
    Aust Vet J 84:321-5. 2006
    ....
  50. ncbi ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4783-91. 2007
    ..phagocytophilum. Taken together, our data demonstrate that ASC and caspase-1 are critical for IFN-gamma-mediated control of A. phagocytophilum infection...
  51. ncbi Molecular evidence for persistence of Anaplasma phagocytophilum in the absence of clinical abnormalities in horses after recovery from acute experimental infection
    P Franzen
    Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Vet Intern Med 23:636-42. 2009
    ..Anaplasma phagocytophilum infects several mammalian species, and can persist in sheep, dogs, and calves. However, whether this organism persists in horses or induces long-term clinical abnormalities is not known...
  52. pmc Identification of Anaplasma marginale outer membrane protein antigens conserved between A. marginale sensu stricto strains and the live A. marginale subsp. centrale vaccine
    Joseph T Agnes
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 79:1311-8. 2011
    ..marginale and provides clear direction for development of a safer, more effective vaccine...
  53. pmc Expression of Anaplasma marginale major surface protein 2 operon-associated proteins during mammalian and arthropod infection
    CHRISTIANE V LOHR
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Infect Immun 70:6005-12. 2002
    ....
  54. ncbi Clinical diagnosis and treatment of human granulocytotropic anaplasmosis
    Johan S Bakken
    St Luke s Infectious Disease Associates, 1001 East First Street, Suite L201, Duluth, Minnesota 55802, USA
    Ann N Y Acad Sci 1078:236-47. 2006
    ..of humans previously known as human granulocytotropic ehrlichiosis (HGE) and now called human granulocytotropic anaplasmosis (HGA)...
  55. ncbi A sero-epidemiological survey of blood parasites in cattle in the north-eastern Free State, South Africa
    M S Mtshali
    Parasitology Research Programme, Qwa Qwa Campus, University of the Free State, Private Bag X 13, Phuthaditjhaba, 9866 South Africa
    Onderstepoort J Vet Res 71:67-75. 2004
    ..The presence of R. evertsi evertsi throughout the year without any or with small fluctuations in winter months was observed, with a peak from February to May...
  56. pmc CD4(+) T-lymphocyte and immunoglobulin G2 responses in calves immunized with Anaplasma marginale outer membranes and protected against homologous challenge
    W C Brown
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 66:5406-13. 1998
    ....
  57. ncbi Detection and quantification of Anaplasma marginale DNA in blood samples of cattle by real-time PCR
    G Carelli
    Department of Animal Health and Well Being, Faculty of Veterinary Medicine of Bari, Strada per Casamassima Km 3, 70010 Valenzano, Bari, Italy
    Vet Microbiol 124:107-14. 2007
    ..marginale DNA in bovine blood, that is essential to support the clinical diagnosis, to assess the carrier status of the animals and to evaluate the efficacy of vaccines and antirickettsial drugs...
  58. ncbi Serologic and molecular characterization of Anaplasma species infection in farm animals and ticks from Sicily
    Jose De La Fuente
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 250 McElory Hall, Stillwater, OK 74078, USA
    Vet Parasitol 133:357-62. 2005
    ..Definition of the diversity of Anaplasma spp. in Sicily reported, herein is fundamental to development of control strategies for A. marginale, A. ovis and A. phagocytophilum in Sicily...
  59. ncbi First serological and molecular evidence on the endemicity of Anaplasma ovis and A. marginale in Hungary
    Sándor Hornok
    Department of Parasitology and Zoology, Faculty of Veterinary Science, Szent Istvan University, Istvan u 2, Budapest, Hungary
    Vet Microbiol 122:316-22. 2007
    ..Haemoglobinuria, an unusual clinical sign for anaplasmosis might have been a consequence of transient intravascular haemolysis facilitated by selenium deficiency in ..
  60. ncbi A review of bovine anaplasmosis
    P Aubry
    Canadian Food Inspection Agency, Ottawa, ON, Canada
    Transbound Emerg Dis 58:1-30. 2011
    Bovine anaplasmosis, caused by Anaplasma marginale, is an infectious but non-contagious disease...
  61. ncbi Conservation of a gene conversion mechanism in two distantly related paralogues of Anaplasma marginale
    Patrick F M Meeus
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32611 0880, USA
    Mol Microbiol 47:633-43. 2003
    Anaplasmataceae, the causative agents of anaplasmosis and ehrlichiosis, persist in the bloodstream of their mammalian hosts, allowing acquisition and transmission by tick vectors...
  62. ncbi First report of bovine anaplasmosis caused by Anaplasma centrale in Europe
    Grazia Carelli
    Department of Animal Health and Well Being, Faculty of Veterinary Medicine of Bari, Valenzano Bari, Italy
    Ann N Y Acad Sci 1149:107-10. 2008
    ..Herein we report a clinical case of bovine anaplasmosis associated with A...
  63. ncbi Molecular detection of Anaplasma platys in dogs using polymerase chain reaction and reverse line blot hybridization
    Olivier A E Sparagano
    School of Agriculture, Food and Rural Development, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    J Vet Diagn Invest 15:527-34. 2003
    ..platys. Sequences obtained from some samples and compared with those within the GenBank also confirmed the presence of A. platys...
  64. pmc Concurrent infections with vector-borne pathogens associated with fatal hemolytic anemia in a cattle herd in Switzerland
    Regina Hofmann-Lehmann
    Clinical Laboratory, University of Zurich, Switzerland
    J Clin Microbiol 42:3775-80. 2004
    Bovine anaplasmosis is a vector-borne disease that results in substantial economic losses in other parts of the world but so far not in northern Europe...
  65. pmc Differences and similarities between culture-confirmed human granulocytic anaplasmosis and early lyme disease
    Gary P Wormser
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA
    J Clin Microbiol 51:954-8. 2013
    ..of certain Ixodes ticks, which can also transmit Anaplasma phagocytophilum, the cause of human granulocytic anaplasmosis (HGA). Although culture can be used to identify patients infected with A...
  66. ncbi Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia
    Y M'Ghirbi
    Service d Entomologie Médicale, Institut Pasteur de Tunis, 1002 Tunis, Tunisia
    Parasitol Res 104:767-74. 2009
    ..phagocytophilum and Ehrlichia sp. RLB findings were confirmed by sequencing; BLAST search against GenBank revealed high similarity of the sequence of Ehrlichia sp. PCR/RLB amplicons with Anaplasma platys 16S rRNA partial sequence...
  67. ncbi Human granulocytic anaplasmosis and macrophage activation
    J Stephen Dumler
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Clin Infect Dis 45:199-204. 2007
    Patients with human granulocytic anaplasmosis present with fever, thrombocytopenia, leukopenia, and an elevated aspartate transaminase level. Clinical and histopathologic features of severe disease suggest macrophage activation...
  68. pmc Multitarget test for emerging Lyme disease and anaplasmosis in a serosurvey of dogs, Maine, USA
    Peter W Rand
    Maine Medical Center Research Institute, South Portland, Maine 04106, USA
    Emerg Infect Dis 17:899-902. 2011
    ..An extension of exposure to Borrelia burgdorferi to the northern border and local transmission of Anaplasma phagocytophilum throughout southern areas was found...
  69. ncbi Genetic characterization of Anaplasma (Ehrlichia) platys in dogs in Spain
    E Aguirre
    Departamento de Medicina y Cirugia Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Vet Med B Infect Dis Vet Public Health 53:197-200. 2006
    ..These data confirm the presence of A. platys in a dog showing clinical signs compatible with ehrlichiosis in Spain...
  70. ncbi First case of human granulocytic anaplasmosis from Slovakia
    Maria Novakova
    Parasitological Institute of the Slovak Academy of Sciences, Kosice, Slovakia
    Ann Agric Environ Med 17:173-5. 2010
    In order to evaluate the potential risks of human granulocytic anaplasmosis in Slovakia, blood and serum samples of hunters and foresters from the northern parth of Slovakia were tested...
  71. ncbi Anaplasmosis: focusing on host-vector-pathogen interactions for vaccine development
    Jose De La Fuente
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Ann N Y Acad Sci 1078:416-23. 2006
    Anaplasma marginale and A. phagocytophylum are intracellular rickettsiae that cause bovine anaplasmosis and human granulocytic anaplasmosis, respectively...
  72. pmc An assessment of whole blood and fractions by nested PCR as a DNA source for diagnosing canine ehrlichiosis and anaplasmosis
    Tereza Emmanuelle de Farias Rotondano
    Departamento de Ciencias Biologicas, Universidade Federal de Pernambuco, Avenue Professor Moraes Rego, S N, Cidade Universitaria, 50 670 901 Recife, PE, Brazil
    ScientificWorldJournal 2012:605743. 2012
    Ehrlichiosis and anaplasmosis are tick-borne diseases. Ehrlichia canis and Anaplasma platys infect mainly white cells and platelets, respectively...
  73. ncbi Diagnostic accuracy of methods for detecting Anaplasma marginale infection in lactating dairy cattle of Puerto Rico
    Geoffrey T Fosgate
    Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, 0110, South Africa
    J Vet Diagn Invest 22:192-9. 2010
    Bovine anaplasmosis (BA) is a hemoparasitic disease of great importance in cattle within the tropical and subtropical regions of the world...
  74. ncbi [Ehrlichiosis and human anaplasmosis]
    Jose Antonio Oteo
    Area de Enfermedades Infecciosas, Complejo Hospitalario San Millán San Pedro de La Rioja, Logrono, Espana
    Enferm Infecc Microbiol Clin 23:375-80. 2005
    Human ehrlichiosis and anaplasmosis are acute febrile tick-borne diseases caused by various species of the genera Ehrlichia and Anaplasma (Anaplasmataceae)...
  75. ncbi Prevalence of Anaplasma marginale in different tick species from Ngorongoro Crater, Tanzania
    Robert D Fyumagwa
    Tanzania Wildlife Research Institute TAWIRI Wildlife Veterinary Programme, P O Box 661, Arusha, Tanzania
    Vet Parasitol 161:154-7. 2009
    ..decoloratus have previously not been described to transmit A. marginale. High diversity of tick species detected with A. marginale in Ngorongoro Crater is likely to increase a risk to susceptible animals of contracting the infection...
  76. ncbi In vivo endothelial cell infection by Anaplasma marginale
    A D Carreño
    Department of Pathobiology, Auburn University, AL 36849 5519, USA
    Vet Pathol 44:116-8. 2007
    ..The results indicate that A marginale infection includes endothelial cells and has implications for both pathogenesis and immune mechanisms...
  77. pmc Clinical findings and diagnosis in human granulocytic anaplasmosis: a case series from Massachusetts
    Ana A Weil
    Department of Medicine, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Mayo Clin Proc 87:233-9. 2012
    To describe clinical findings and the use of a tick-associated pathogen panel in a series of patients with human granulocytic anaplasmosis (HGA) at a suburban Boston hospital.
  78. ncbi Adaptations of the tick-borne pathogen, Anaplasma marginale, for survival in cattle and ticks
    Katherine M Kocan
    Department of Veterinary Pathobiology, 250 McElroy Hall, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078 2007, USA
    Exp Appl Acarol 28:9-25. 2002
    ..Infection and development of A. marginale in cattle and tick cells appears to differ and to be mediated by several surface proteins encoded from the small genome...
  79. ncbi Anaplasma phagocytophilum in Ixodes ricinus ticks and human granulocytic anaplasmosis seroprevalence among forestry rangers in Białystok region
    A Grzeszczuk
    Department of Infectious Diseases, Medical University of Białystok, Poland
    Adv Med Sci 51:283-6. 2006
    Human granulocytic anaplasmosis, former ehrlichiosis, is a tick-borne zoonosis of increasing recognition...
  80. ncbi Structural basis for segmental gene conversion in generation of Anaplasma marginale outer membrane protein variants
    James E Futse
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Mol Microbiol 57:212-21. 2005
    ..Importantly, the anchoring model, which can account for more variants than a strict segmental sequence identity mechanism, is consistent with the number of msp2 variants predicted and empirically identified during persistent infection...
  81. ncbi Failure to demonstrate Babesia, Anaplasma or Ehrlichia in thrombocytopenic dogs from St Kitts
    Patrick J Kelly
    Ross University School of Veterinary Medicine, PO Box 334, Basseterre, St Kitts, West Indies
    J Infect Dev Ctries 3:561-3. 2009
    ..Thrombocytopenia is common in dogs on St Kitts but there is no data on the possible etiological role played by infections with Anaplasma, Babesia and Ehrlichia, other than E. canis, which are known to occur in the Caribbean...
  82. ncbi Human anaplasmosis: the first Spanish case confirmed by PCR
    J C Garcia
    Servicio de Medicina Interna, F P Hospital Do Salnés, C Estromil Ande Rubians, 36600 Vilagarcía de Arousa Pontevedra, Spain
    Ann N Y Acad Sci 1078:545-7. 2006
    We report a case of human anaplasmosis (HA) fulfilling the confirmation criteria: epidemiologic data and clinical picture compatible with HA; presence of a morulae within polymorphonuclear leukocyte; and positive PCR assay for Anaplasma ..
  83. ncbi Serologic evidence of equine granulocytic anaplasmosis in horses from central West Brazil
    Carlos Augusto Salvagni
    Departamento de Patologia Veterinária, FCAV UNESP, Universidade Estadual Paulista UNESP
    Rev Bras Parasitol Vet 19:135-40. 2010
    ..Equine Granulocytic Anaplasmosis - EGA (formerly Equine Granulocytic Ehrlichiosis, EGE) is a seasonal disease, normally self-limited in horses...
  84. ncbi Occurrence of concurrent trypanosomosis, theileriosis, anaplasmosis and helminthosis in Friesian, Zebu and Sahiwal cattle in Uganda
    J W Magona
    Livestock Health Research Institute, Tororo, Uganda
    Onderstepoort J Vet Res 69:133-40. 2002
    ..Persistent mortality of cattle on these farms could have been due to either single or mixed parasitic infections probably exacerbated by malnutrition...
  85. pmc The immunization-induced antibody response to the Anaplasma marginale major surface protein 2 and its association with protective immunity
    Susan M Noh
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, WA 99164 7030, USA
    Vaccine 28:3741-7. 2010
    ....
  86. ncbi Immune response of BALB/c mouse immunized with recombinant MSPs proteins of Anaplasma marginale binding to immunostimulant complex (ISCOM)
    Paula M Kawasaki
    Universidade Estadual de Londrina, Departamento Medicina Veterinária Preventiva, CCA, Campus Universitario, Caixa Postal 6001, 86051 970 Londrina, PR, Brazil
    Res Vet Sci 83:347-54. 2007
    b>Anaplasmosis, caused by Anaplasma marginale, results in significant economic losses of cattle in tropical and subtropical regions worldwide...
  87. ncbi Tick- and flea-borne rickettsial emerging zoonoses
    Philippe Parola
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 5, France
    Vet Res 36:469-92. 2005
    ..Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis, Anaplasma phagocytophilum, the agent of human anaplasmosis (formerly known as "human granulocytic ehrlichiosis agent", E. equi and E...
  88. ncbi Amplification of 16S rRNA genes of Anaplasma species in China for phylogenetic analysis
    Zhijie Liu
    Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 11, Lanzhou, Gansu 730 046, China
    Vet Microbiol 107:145-8. 2005
    ..ovis cluster, while the A. marginale in China was separated into an A. marginale cluster (see Fig. 1). This analysis demonstrated that there are at least two different Anaplasma species widespread among ruminants in North China...
  89. ncbi Genetic diversity of major surface protein 1a of Anaplasma marginale in beef cattle
    T Molad
    Division of Parasitology, Kimron Veterinary Institute, Bet Dagan 50250, Israel
    Vet Microbiol 136:54-60. 2009
    ..study was aimed to demonstrate genotypic diversity of Anaplama marginale in infected beef herds grazing within anaplasmosis endemic regions...
  90. ncbi [Anaplasmosis in a Swiss dairy farm: an epidemiological outbreak investigation]
    F Brulisauer
    Bundesamt für Veterinärwesen, Bern
    Schweiz Arch Tierheilkd 146:451-9. 2004
    In summer of 2002, a case of severe clinical bovine anaplasmosis caused great losses in a dairy farm of an animal trader in Grisons...
  91. ncbi Anaplasma marginale Yucatan (Mexico) Strain. Assessment of low virulence and potential use as a live vaccine
    Sergio D Rodríguez Camarillo
    Centro de Investigaciones Disciplinarias, en Parasitología Veterinaria, Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias, Secretaría de Agricultura, Ganaderia, Desarrollo Rural, Pesca y Alimentació, Jiutepec, Morelos, Mexcio
    Ann N Y Acad Sci 1149:98-102. 2008
    ..The A. marginale vaccine strains used for the immunization studies had MSP1a variable regions that were different from those used for the challenge exposure...
  92. ncbi Concomitant infection of cattle with the vaccine strain Anaplasma marginale ss centrale and field strains of A. marginale
    Varda Shkap
    Division of Parasitology, Kimron Veterinary Institute, Bet Dagan, Israel
    Vet Microbiol 130:277-84. 2008
    Bovine anaplasmosis, caused by Anaplasma marginale, the intraerythrocytic rickettsia, is controlled by vaccination with live Anaplasma marginale ss centrale (A. centrale), a subspecies of relatively low pathogenicity...
  93. ncbi Molecular epidemiology of bovine anaplasmosis with a particular focus in Mexico
    Sergio D Rodríguez
    Departamento de Infectómica y Patogénesis Molecular, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico DF 07360, Mexico
    Infect Genet Evol 9:1092-101. 2009
    Bovine anaplasmosis, caused by the rickettsia Anaplasma marginale, has a worldwide distribution and is the cause of great economic losses in developing countries where it is highly endemic...
  94. pmc Composition of the surface proteome of Anaplasma marginale and its role in protective immunity induced by outer membrane immunization
    Susan M Noh
    Animal Disease Research Unit, Agriculture Research Service, U S Department of Agriculture, Pullman, WA 99164 7030, USA
    Infect Immun 76:2219-26. 2008
    ..Furthermore, the data support that remodeling of the surface proteome accompanies the transition between mammalian and arthropod hosts and identify novel targets for blocking transmission...
  95. ncbi Potential vertebrate reservoir hosts and invertebrate vectors of Anaplasma marginale and A. phagocytophilum in central Spain
    Jose De La Fuente
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ciudad Real, Spain
    Vector Borne Zoonotic Dis 5:390-401. 2005
    ..The type species, A. marginale, causes bovine anaplasmosis and only infects ticks and ruminants. A...
  96. ncbi Molecular detection of Anaplasma platys and Ehrlichia canis in dogs from the North of Portugal
    Luis Cardoso
    Department of Veterinary Sciences and CECAV, University of Tras os Montes e Alto Douro, P O Box 1013, 5001 801 Vila Real, Portugal
    Vet J 183:232-3. 2010
    ..One of these latter animals was co-infected with Babesia canis subspecies vogeli. This is the first report of the genetic characterisation of both A. platys and E. canis in naturally infected dogs from the North of Portugal...
  97. ncbi Molecular characterization of Thai Ehrlichia canis and Anaplasma platys strains detected in dogs
    Danai Pinyoowong
    Department of Genetics, Faculty of Science, Kasetsart University, Thailand
    Infect Genet Evol 8:433-8. 2008
    ..platys from Thailand. To our knowledge this report represents the first molecular characterization of the nearly complete 16S rRNA gene from E. canis in dogs from Thailand...
  98. ncbi Studies on correlations among parasitaemia and some hemolytic indices in two tropical diseases (theileriosis and anaplasmosis) in Fars province of Iran
    S Nazifi
    Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, P O Box 1731, Shiraz 71345, Iran
    Trop Anim Health Prod 40:47-53. 2008
    ..increased the anaemia, MCF and LDH activity increased and SOD activity decreased at any parasitaemia, but in anaplasmosis the anaemia, MCF and LDH activity increased at any parasitaemia but SOD activity decreased only in early but ..
  99. pmc Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals
    Guy H Palmer
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 75:1502-6. 2007
    ..However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission...
  100. ncbi Reduced weight gain due to subclinical Anaplasma phagocytophilum (formerly Ehrlichia phagocytophila) infection
    Snorre Stuen
    Norwegian School of Veterinary Science, Department of Sheep and Goat Research, Kyrkjevegen 332 334, N 4325 Sandnes, Norway
    Exp Appl Acarol 28:209-15. 2002
    ..8 kg compared with the uninfected lambs. The present study indicates that A. phagocytophilum infection may be widespread and contribute to considerable productivity losses even on pastures with no apparent tick infestation...
  101. ncbi Human anaplasmosis presenting as atypical pneumonitis in France
    V Remy
    Service de Maladies Infectieuses et Pathologies Tropicales, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    Clin Infect Dis 37:846-8. 2003
    Human anaplasmosis is a febrile illness caused by Anaplasma phagocytophilum, an intracellular bacterium transmitted by Ixodes ticks in the United States and Europe...

Research Grants54

  1. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    ..conori causing Boutenneuse fever;Francisella tularensis causing tularemia in humans;and pathogens causing anaplasmosis, babesioses, and theileriosis in animals. These species also transmit several viruses that cause human diseases...
  2. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human granulocytic anaplasmosis (HGA) is a severe illness with a fatality rate of <5% that, like spotted fever, is caused by tick-borne intracellular bacteria, presenting a highly relevant, ..
  3. Symbiotic Rickettsia Species as a Model System for the Study of Folate Biosynthes
    Jianmin Zhong; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Lyme borreliosis and anaplasmosis are the most common tick-borne diseases in the United States, and prevention of these diseases has become the ..
  4. Tick feeding regulation by orthologous tick saliva serine protease inhibitors
    Albert Mulenga; Fiscal Year: 2013
    ..in the emergence of major human tick borne diseases (TBD) in the United States, Lyme disease, human anaplasmosis, babesiosis and ehrlichiosis and the southern tick-associated rash illness (STARI) has been recognized...
  5. TYPE IV SECRETION &SIGNAL TRANSDUCTION IN EHRLICHIOSIS
    Yasuko Rikihisa; Fiscal Year: 2013
    ..and Ehrlichia chaffeensis cause emerging potentially fatal infectious diseases human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME), respectively...
  6. Identification of bacterial genes required for transmission of tick-borne pathoge
    Susan M Noh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Tick-borne diseases, including anaplasmosis, ehrlichiosis, and several rickettsial diseases, remain poorly controlled amid increasing incidence...
  7. Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis
    Erol Fikrig; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human granulocytic anaplasmosis is the second most common tick-borne disease in the United States...
  8. Anaplasma regulation of host granulocyte function
    John Stephen Dumler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human granulocytic anaplasmosis (HGA) is an emerging tick-borne disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils. A...
  9. Human pathogenic bacterium induces actin phosphorylation to selectively regulate
    Hameeda Sultana; Fiscal Year: 2012
    ..Using Ixodes scapularis ticks and Anaplasma phagocytophilum (the agent of human granulocytic anaplasmosis) as an infection model, I provide evidence for the first time to show how an obligate intracellular bacterium ..
  10. Overwintering mortality of nymphal Ixodes scapularis, Lyme disease vector, in a c
    RICHARD S contact OSTFELD; Fiscal Year: 2010
    ..vectors the agents of three emerging infectious diseases in North America: Lyme disease, human granulocytic anaplasmosis, and babesiosis...
  11. Characterization of an Anaplasma phagocytophilum protein interfering with eukaryo
    Sukanya Narasimhan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Anaplasma phagocytophilum, the causative agent of human Anaplasmosis, is a tick-borne pathogen with an unusual tropism for the front-line immune defense cells (neutrophils)...
  12. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2013
    ..phagocytophilum is a tick-borne obligate intracellular bacterial pathogen and the agent of granulocytic anaplasmosis in humans and animals. A...
  13. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2011
    ..phagocytophilum is a tick-borne obligate intracellular bacterial pathogen and the agent of granulocytic anaplasmosis in humans and animals. A...
  14. Vector and Host Contributions to the Regulation of E. chaffeensis Gene Expression
    Roman R Ganta; Fiscal Year: 2012
    ..These illnesses include human monocytic ehrlichiosis, human granulocytic ehrlichiosis and human granulocytic anaplasmosis which are caused by Ehrlichia chaffeensis, E. ewingii and Anaplasma phagocytophilum, respectively...
  15. LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALE
    Reginald Valdez; Fiscal Year: 1999
    ..There was some uncertainty as to the extent of the problem of acute anaplasmosis infection in cattle and how the research findings might impact the field. Since Dr...
  16. Keys to prevent cholesterol robbery and infection by intracellular bacteria
    Yasuko Rikihisa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human granulocytic anaplasmosis (HGA) is an emerging zoonosis, and one of the most prevalent life- threatening tick-borneillnesses in North America...
  17. 13th International Conference on Lyme Borreliosis and Other Tick-borne Diseases
    Linden T Hu; Fiscal Year: 2013
    ..The diseases included in this conference are Lyme borreliosis, babesiosis, human granulocytic anaplasmosis (ehrlichiosis) and tick-borne encephalitis...
  18. Anaplasma phagocytophilum induce Ixodes scapularis antifreeze glycoprotein gene e
    Girish Neelakanta; Fiscal Year: 2012
    ..the Northeast and Upper Midwest parts of United States, and transmit various human pathogens that include human anaplasmosis agent Anaplasma phagocytophilum. My preliminary data show that the presence of A...
  19. The roles of Anaplasma phagocytophilum surface proteins in cellular invasion
    Jason A Carlyon; Fiscal Year: 2013
    ..neutrophils and endothelial cells to cause the emerging and potentially fatal infection, human granulocytic anaplasmosis (HGA). A...
  20. The roles of Anaplasma phagocytophilum surface proteins in cellular invasion
    Jason A Carlyon; Fiscal Year: 2012
    ..neutrophils and endothelial cells to cause the emerging and potentially fatal infection, human granulocytic anaplasmosis (HGA). A...
  21. Ehrlichiacidal Mechanism in Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2011
    Human granulocytic anaplasmosis (HGA) is one of most prevalent life-threatening tick-borne zoonoses in North America. This disease is caused by Anaplasma phagocytophilum, a Gram-negative obligatory intracellular bacterium. A...
  22. A. phagocytophilum and NF-kB signaling
    John Stephen Dumler; Fiscal Year: 2010
    Human granulocytic anaplasmosis (HGA) is tick-borne disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils. A...
  23. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2006
    ..diseases are human monocytotropic ehrlichiosis (HME), caused by Ehrlichia chaffeensis; and human granulocytic anaplasmosis (HGA) caused by Anaplasma phagocytophilum...
  24. Anaplasma - B. burgorferi/endothelijm interactions
    DENNIS GRAB; Fiscal Year: 2006
    ..Human granulocytic anaplasmosis (HGA) is caused by Anaplasma phagocytophilum, a rickettsia of neutrophils that is also transmitted by the deer ..
  25. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2007
    ..of the mechanisms of pathogenesis of tick- borne rickettsial pathogens that cause ehrlichiosis and anaplasmosis of humans and animals. These pathogens efficiently utilize a small genome (<1...
  26. A Rickettsial Symbiont Model for the Control of Tick-borne Diseases
    Jianmin Zhong; Fiscal Year: 2009
    ..Lyme borreliosis and human granulocytic anaplasmosis are severe bacterial diseases that, in California, are vectored primarily by Ixodes pacificus ticks...
  27. Immunity directed against MSP 2 during anaplasmosis
    Jeffrey Abbott; Fiscal Year: 2004
    ..Levels of rickettsemia during persistent anaplasmosis are approximately two orders of magnitude less than rickettsemia levels during acute infection and do not ..
  28. Anaplasma marginale genes determining tick transmission
    MICHAEL DARK; Fiscal Year: 2007
    ..The genera Anaplasma and Ehriichia, including the organisms responsible for human anaplasmosis and human ehrlichiosis, require an ixodid tick vector for transmission from a mammalian reservoir to a ..
  29. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2007
    ABSTRACT Human granulocytic anaplasmosis (HGA) is a tick-borne infection caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils...
  30. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2005
    ..This information will provide the framework for rational design of new therapies aimed at modulating immune mechanisms and design of preventative measures aimed at immunization. ..
  31. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..These efforts are expected to reveal an important role for the p44-multigene family in strategies of adaptive surface variation and avoidance of host immune responses. ..
  32. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    ..The results may point to a potential target for new treatment and prevention of HME and HGE. ..
  33. ROLES OF EHRLICHIAL OUTER MEMBRANE PROTEIN IN PARASITISM
    Yasuko Rikihisa; Fiscal Year: 2001
    ..Aim 5 addresses hypothesis 3 by examining the effects of immunization with the ehrlichial OMP in a mouse model of human ehrlichiosis. ..
  34. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    ..chaffeensis virulence determinants and their pathogenic mechanisms. The results may point to potential chemotherapy, chemopreventive and/or vaccine candidates for treatment and prevention of human ehrlichiosis. ..
  35. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..and animal diseases including human granulocytic ehrlichiosis (HGE), equine ehrlichiosis, and bovine and ovine anaplasmosis. These pathogens are small, Gram-negative, obligately intracellular bacteria that require ixodid ticks for ..
  36. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2008
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
  37. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. Immunopathogenesis of Human Granulocytic Anaplasmosis
    Erol Fikrig; Fiscal Year: 2008
    Summary/Abstract Human granulocytic anaplasmosis is the second most common tick-borne disease in the United States...
  39. Granulocytic Ehrlichiosis: Cell-Pathogen Interactions
    Dori Borjesson; Fiscal Year: 2005
    ..Currently, the candidate is a junior faculty member at a strong research institution with a clear mandate and desire to pursue an independent research program. ..
  40. PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSIS
    Ulrike Munderloh; Fiscal Year: 2001
    ....
  41. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2002
    ..chaffeensis and other closely related organisms. ..
  42. Antigenic variation of Anaplasma marginale
    PATRICK MEEUS; Fiscal Year: 2003
    ..Investigations of bovine anaplasmosis offer a unique opportunity to study the mechanisms of antigenic variation in a natural animal model under ..
  43. LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 2008
    ..Development of this risk model, which culminates over 2 decades of intensive study, should contribute significantly to our knowledge of the landscape ecology and epidemiology of LD in this region. ..
  44. Symposium on the Landscape Ecology of Infectious Disease
    MICHAEL WIMBERLY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. Identifying human genes required by tick-borne pathogens
    Ulrike Munderloh; Fiscal Year: 2007
    ..We anticipate that the interaction of the human host cells with these highly specialized intracellular pathogens will shed light,on the nature of some unidentified human genes. [unreadable] [unreadable] [unreadable]..
  46. Diagnosis and Pathogenesis of Early Lyme Disease
    Allen Steere; Fiscal Year: 2007
    ..In addition, greater knowledge of spirochetal virulence and host factors associated with severe disease may allow the development of laboratory markers for patients who would benefit from more intensive treatment. ..
  47. American Society for Rickettsiology conference
    ROMAN GANTA; Fiscal Year: 2005
    ..abstract_text> ..
  48. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..
  49. Gammacell-220 Excel Refurbished Research Irradiator
    David Walker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  50. Identification of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Human granulocytic anaplasmosis (HGA; formerly human granulocytic ehrlichiosis) is an emerging and potentially deadly disease...
  51. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen C Steere; Fiscal Year: 2010
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  52. Regulation of gp91phox by Anaplasma phagocytophila
    Venetta Thomas; Fiscal Year: 2007
    ..Aim 2. To define the effect of A. phagocytophila infection on the activity of the activator proteins and their binding capacity of the gp91phox promoter. ..
  53. Natural History of Borrelia lonestari
    Susan Little; Fiscal Year: 2006
    ..S., enhancing public health efforts in those areas where people are risk of infection; reduction in human disease from these pathogens should result. [unreadable] [unreadable] [unreadable] [unreadable]..
  54. American Society for Rickettsiology Conference 2006
    ROMAN GANTA; Fiscal Year: 2006
    ..abstract_text> ..