newcastle disease

Summary

Summary: An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.

Top Publications

  1. ncbi Genetic diversity of avian paramyxovirus type 1: proposal for a unified nomenclature and classification system of Newcastle disease virus genotypes
    Diego G Diel
    Southeast Poultry Research Laboratory, United States Department of Agriculture, Agricultural Research Services, 934 College Station Rd, Athens, GA 30605, United States
    Infect Genet Evol 12:1770-9. 2012
  2. ncbi Newcastle disease: evolution of genotypes and the related diagnostic challenges
    Patti J Miller
    Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, GA 30052, USA
    Infect Genet Evol 10:26-35. 2010
  3. ncbi Newcastle disease and other avian paramyxoviruses
    D J Alexander
    Central Veterinary Laboratory, Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    Rev Sci Tech 19:443-62. 2000
  4. ncbi Role of fusion protein cleavage site in the virulence of Newcastle disease virus
    Aruna Panda
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Microb Pathog 36:1-10. 2004
  5. ncbi Virulence of Newcastle disease virus is determined by the cleavage site of the fusion protein and by both the stem region and globular head of the haemagglutinin-neuraminidase protein
    Olav S de Leeuw
    Wageningen University and Research Centre, Animal Sciences Group, Division of Infectious Diseases, 8200 AB Lelystad, The Netherlands
    J Gen Virol 86:1759-69. 2005
  6. pmc Virulence of Newcastle disease virus: what is known so far?
    Jos C F M Dortmans
    Central Veterinary Institute of Wageningen UR, PO Box 65, 8200 AB Lelystad, The Netherlands
    Vet Res 42:122. 2011
  7. ncbi Newcastle disease virus outbreaks: vaccine mismatch or inadequate application?
    Jos C F M Dortmans
    Central Veterinary Institute of Wageningen UR, 8200 AB Lelystad, The Netherlands
    Vet Microbiol 160:17-22. 2012
  8. ncbi Gordon Memorial Lecture. Newcastle disease
    D J Alexander
    Br Poult Sci 42:5-22. 2001
  9. ncbi Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications
    Alíz Czeglédi
    Veterinary Medical Research Institute of the Hungarian Academy of Sciences, PO Box 18, Budapest 1581, Hungary
    Virus Res 120:36-48. 2006
  10. ncbi A molecular epidemiological study of avian paramyxovirus type 1 (Newcastle disease virus) isolates by phylogenetic analysis of a partial nucleotide sequence of the fusion protein gene
    E W Aldous
    Virology Department Veterinary Laboratories Agency Weybridge New Haw, Addlestone KT15 3NB Surrey, UK
    Avian Pathol 32:239-56. 2003

Detail Information

Publications306 found, 100 shown here

  1. ncbi Genetic diversity of avian paramyxovirus type 1: proposal for a unified nomenclature and classification system of Newcastle disease virus genotypes
    Diego G Diel
    Southeast Poultry Research Laboratory, United States Department of Agriculture, Agricultural Research Services, 934 College Station Rd, Athens, GA 30605, United States
    Infect Genet Evol 12:1770-9. 2012
    The avian paramyxovirus type 1 (APMV-1), or Newcastle disease virus (NDV), comprise a diverse group of viruses with a single-stranded, negative-sense RNA genome...
  2. ncbi Newcastle disease: evolution of genotypes and the related diagnostic challenges
    Patti J Miller
    Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, GA 30052, USA
    Infect Genet Evol 10:26-35. 2010
    Since the discovery of Newcastle disease virus (NDV) in 1926, nine genotypes of class I viruses and ten of class II have been identified, representing a diverse and continually evolving group of viruses...
  3. ncbi Newcastle disease and other avian paramyxoviruses
    D J Alexander
    Central Veterinary Laboratory, Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    Rev Sci Tech 19:443-62. 2000
    b>Newcastle disease (ND), caused by avian paramyxovirus serotype 1 (APMV-1) viruses, is included in List A of the Office International des Epizooties...
  4. ncbi Role of fusion protein cleavage site in the virulence of Newcastle disease virus
    Aruna Panda
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Microb Pathog 36:1-10. 2004
    b>Newcastle disease virus (NDV) causes a highly contagious and economically important disease in poultry. Viral determinants of NDV virulence are not completely understood...
  5. ncbi Virulence of Newcastle disease virus is determined by the cleavage site of the fusion protein and by both the stem region and globular head of the haemagglutinin-neuraminidase protein
    Olav S de Leeuw
    Wageningen University and Research Centre, Animal Sciences Group, Division of Infectious Diseases, 8200 AB Lelystad, The Netherlands
    J Gen Virol 86:1759-69. 2005
    Virulence of Newcastle disease virus (NDV) is mainly determined by the amino acid sequence surrounding the fusion (F) protein cleavage site, since host proteases that cleave the F protein of virulent strains are present in more tissues ..
  6. pmc Virulence of Newcastle disease virus: what is known so far?
    Jos C F M Dortmans
    Central Veterinary Institute of Wageningen UR, PO Box 65, 8200 AB Lelystad, The Netherlands
    Vet Res 42:122. 2011
    In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV)...
  7. ncbi Newcastle disease virus outbreaks: vaccine mismatch or inadequate application?
    Jos C F M Dortmans
    Central Veterinary Institute of Wageningen UR, 8200 AB Lelystad, The Netherlands
    Vet Microbiol 160:17-22. 2012
    b>Newcastle disease (ND) is one of the most important diseases of poultry, and may cause devastating losses in the poultry industry worldwide. Its causative agent is Newcastle disease virus (NDV), also known as avian paramyxovirus type 1...
  8. ncbi Gordon Memorial Lecture. Newcastle disease
    D J Alexander
    Br Poult Sci 42:5-22. 2001
    1. In this paper several historical and contemporary aspects of Newcastle disease (ND) are reviewed, with particular reference to the greater understanding which modern techniques have allowed. 2...
  9. ncbi Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications
    Alíz Czeglédi
    Veterinary Medical Research Institute of the Hungarian Academy of Sciences, PO Box 18, Budapest 1581, Hungary
    Virus Res 120:36-48. 2006
    ..Therefore the complete genome sequence of two distinct apathogenic Newcastle disease virus (NDV) strains was determined and a third genome size category, containing 15,198 nucleotides, was ..
  10. ncbi A molecular epidemiological study of avian paramyxovirus type 1 (Newcastle disease virus) isolates by phylogenetic analysis of a partial nucleotide sequence of the fusion protein gene
    E W Aldous
    Virology Department Veterinary Laboratories Agency Weybridge New Haw, Addlestone KT15 3NB Surrey, UK
    Avian Pathol 32:239-56. 2003
    ..cleavage activation site and signal peptide of the fusion protein gene, was determined for 174 isolates of Newcastle disease virus (avian paramyxovirus type 1)...
  11. pmc Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines
    Sateesh Krishnamurthy
    Department of Infectious Diseases, Mail Stop 330, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Virol 80:5145-55. 2006
    b>Newcastle disease virus (NDV) is a negative-strand RNA virus with oncolytic activity against human tumors. Its effectiveness against tumors and safety in normal tissue have been demonstrated in several clinical studies...
  12. ncbi Newcastle disease in the European Union 2000 to 2009
    Dennis J Alexander
    Virology Department, Animal Health and Veterinary Laboratories Agency Weybridge, Addlestone, Surrey, UK
    Avian Pathol 40:547-58. 2011
    b>Newcastle disease (ND) is a devastating disease of poultry that has to some extent been neglected by those working in the field in the past 10 to 15 years while attention has been focused on the emergence and spread of highly pathogenic ..
  13. ncbi Protection of chickens against overt clinical disease and determination of viral shedding following vaccination with commercially available Newcastle disease virus vaccines upon challenge with highly virulent virus from the California 2002 exotic Newcastl
    Darrell R Kapczynski
    Southeast Poultry Research Laboratory, Agricultural Research Service, USDA, 934 College Station Road, Athens, GA 30605, USA
    Vaccine 23:3424-33. 2005
    During 2002-2003, exotic Newcastle disease (END) virus caused a major outbreak among commercial and backyard poultry in southern California and adjacent states...
  14. ncbi Comparison of viral shedding following vaccination with inactivated and live Newcastle disease vaccines formulated with wild-type and recombinant viruses
    Patti J Miller
    Southeast Poultry Research Laboratory, USDA ARS, 934 College Station Road, Athens, GA 30605, USA
    Avian Dis 53:39-49. 2009
    Virulent Newcastle disease virus isolates from the 1971 and 2002 U.S. outbreaks are of the same serotype but a different genotype than current vaccine strains...
  15. pmc Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia
    Sa Xiao
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:5969-70. 2012
    Eight highly virulent Newcastle disease virus (NDV) strains were isolated from vaccinated commercial chickens in Indonesia during outbreaks in 2009 and 2010...
  16. pmc Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza
    Jutta Veits
    Institute of Molecular Biology, Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Boddenblick 5a, D 17493 Greifswald Insel Riems, Germany
    Proc Natl Acad Sci U S A 103:8197-202. 2006
    b>Newcastle disease virus (NDV)-expressing avian influenza virus (AIV) hemagglutinin (HA) of subtype H5 was constructed by reverse genetics...
  17. ncbi Velogenic newcastle disease virus as an oncolytic virotherapeutics: in vitro characterization
    Rajiv Kumar
    Molecular Biology Laboratory, Department of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar 243122, UP, India
    Appl Biochem Biotechnol 167:2005-22. 2012
    ..Oncolytic virotherapy seems to be a promising nonconventional way to treat cancers. Newcastle disease virus (NDV), a poultry virus, is nonpathogenic to human and domestic animals and has a long history of being ..
  18. pmc Complete genome sequence of a novel Newcastle disease virus strain isolated from a chicken in West Africa
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:11394-5. 2012
    The complete genome sequence of an African Newcastle disease virus (NDV) strain isolated from a chicken in Togo in 2009 was determined...
  19. ncbi Prevalence of infectious bronchitis and Newcastle disease virus among domestic and wild birds in H5N1 outbreaks areas
    Zekiba Tarnagda
    Institut de recherche en sciences de la sante, Bobo Dioulasso, Burkina Faso
    J Infect Dev Ctries 5:565-70. 2011
    ..This study aimed to determine the prevalence of avian influenza virus, infectious bronchitis virus, and Newcastle disease virus among domestic and wild birds in highly pathogenic avian influenza (HPAI) H5N1 outbreaks areas.
  20. pmc Phylogenetic and biological characterization of Newcastle disease virus isolates from Pakistan
    Taseer Ahmed Khan
    USDA ARS, Southeast Poultry Research Laboratory, 934 College Station Rd, Athens, GA 30605, USA
    J Clin Microbiol 48:1892-4. 2010
    Eight Newcastle disease virus isolates from Pakistan were sequenced and characterized. A PCR matrix gene assay, designed to detect all avian paramyxovirus 1, did not detect four of the isolates...
  21. pmc Evaluation of the Newcastle disease virus F and HN proteins in protective immunity by using a recombinant avian paramyxovirus type 3 vector in chickens
    Sachin Kumar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 85:6521-34. 2011
    b>Newcastle disease virus (NDV) belongs to serotype 1 of the avian paramyxoviruses (APMV-1) and causes severe disease in chickens. Current live attenuated NDV vaccines are not fully satisfactory...
  22. pmc Experimental infection of mice with avian paramyxovirus serotypes 1 to 9
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 6:e16776. 2011
    ..APMV-1, also called Newcastle disease virus, was shown to be attenuated in non-avian species and is being developed as a potential vector for ..
  23. pmc Immunization of cattle with recombinant Newcastle disease virus expressing bovine herpesvirus-1 (BHV-1) glycoprotein D induces mucosal and serum antibody responses and provides partial protection against BHV-1
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Vaccine 28:3159-70. 2010
    ..Thus, there is a need for alternative strategies. We generated two recombinant Newcastle disease viruses (NDVs) expressing the glycoprotein D (gD) of BHV-1 from an added gene...
  24. pmc A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 83:7779-82. 2009
    The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is a multifunctional protein that plays a crucial role in virus infectivity...
  25. ncbi Evaluation of Newcastle disease virus chimeras expressing the Hemagglutinin-Neuraminidase protein of velogenic strains in the context of a mesogenic recombinant virus backbone
    Carlos Estevez
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA
    Virus Res 129:182-90. 2007
    A major factor in the pathogenicity of Newcastle disease virus (NDV) is the amino acid sequence of the fusion protein cleavage site, but the role of other viral genes that contribute to virulence and different clinical forms of the ..
  26. pmc Newcastle disease virus in Madagascar: identification of an original genotype possibly deriving from a died out ancestor of genotype IV
    Olivier F Maminiaina
    FOFIFA DRZV, Antananarivo, Madagascar
    PLoS ONE 5:e13987. 2010
    In Madagascar, Newcastle disease (ND) has become enzootic after the first documented epizootics in 1946, with recurrent annual outbreaks causing mortality up to 40%...
  27. pmc Pathotypical characterization and molecular epidemiology of Newcastle disease virus isolates from different hosts in China from 1996 to 2005
    Zhuo ming Qin
    Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China
    J Clin Microbiol 46:601-11. 2008
    Thirty Newcastle disease virus (NDV) strains isolated from outbreaks in China during 1996 to 2005 were characterized pathotypically and genotypically. All strains except one were velogenic...
  28. ncbi Phylogenetic characterization of Newcastle disease virus isolated in the mainland of China during 2001-2009
    Zhang Rui
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    Vet Microbiol 141:246-57. 2010
    Twenty Newcastle disease virus (NDV) isolates from infected chicken flocks during 2001 to 2009 in China were biologically and genetically characterized...
  29. pmc Phylogenetic analysis of Newcastle disease virus genotypes isolated in Japan
    Masaji Mase
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Clin Microbiol 40:3826-30. 2002
    We genetically analyzed field isolates of the Newcastle disease (ND) virus isolated in Japan from 1930 to 2001. The coding region of the fusion protein was amplified by reverse transcriptase PCR and directly sequenced...
  30. ncbi Emergence of a new genetic lineage of Newcastle disease virus in West and Central Africa--implications for diagnosis and control
    G Cattoli
    OIE FAO Reference Laboratory for avian influenza and Newcastle disease, Istituto Zooprofilattico Sperimentale delle Venezie, Virology Department, Legnaro PD, Italy
    Vet Microbiol 142:168-76. 2010
    b>Newcastle disease (ND) is an OIE listed disease caused by virulent avian paramyxovirus type 1 (APMV-1) strains, which affect many species of birds and may cause severe economic losses in the poultry sector...
  31. ncbi A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Gen Virol 92:2333-8. 2011
    A key determinant of Newcastle disease virus (NDV) virulence is the amino acid sequence at the fusion (F) protein cleavage site...
  32. ncbi Experimental pathogenesis for chickens, turkeys, and pigeons of exotic Newcastle disease virus from an outbreak in California during 2002-2003
    N Wakamatsu
    Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D W Brooks Drive, Athens, GA 30602 7388, USA
    Vet Pathol 43:925-33. 2006
    Exotic Newcastle disease virus (NDV) isolated from chickens during the 2002-2003 California outbreak (CA exotic Newcastle disease [END] virus) was inoculated into 4-week-old specific-pathogen-free (SPF) White Leghorn chickens, 3-week-old ..
  33. ncbi Rapid detection of Newcastle disease virus replication in embryonated chicken eggs using quantitative real time polymerase chain reaction
    V P Gopinath
    Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, India
    J Virol Methods 171:98-101. 2011
    b>Newcastle disease virus (NDV), an avian paramyxovirus, is an economically important disease of poultry globally. Rapid methods to detect and differentiate the virus are important to curtail the spread of this virus...
  34. ncbi Genetic characterization and evolutionary analysis of 4 Newcastle disease virus isolate full genomes from waterbirds in South China during 2003-2007
    Shaoxin Cai
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China
    Vet Microbiol 152:46-54. 2011
    Complete genomes of four Newcastle disease virus (NDV) strains, isolated from ducks and wild birds in Guangdong province of China from 2003 to 2007, were sequenced and analyzed in this study...
  35. ncbi Sensitive, semi-nested RT-PCR amplification of fusion gene sequences for the rapid detection and differentiation of Newcastle disease virus
    Lei Zhang
    Jiangsu Key Laboratory of Zoonosis, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China
    Res Vet Sci 89:282-9. 2010
    ..and specific semi-nested RT-PCR was developed to detect and differentiate virulent and avirulent strains of Newcastle disease virus (NDV)...
  36. ncbi Selective isolation of Avian influenza virus (AIV) from cloacal samples containing AIV and Newcastle disease virus
    Mohamed E El Zowalaty
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
    J Vet Diagn Invest 23:330-2. 2011
    ..In addition to AIV, waterfowl are often coinfected with other viruses, such as the paramyxoviruses, of which Newcastle disease virus (NDV) is of particular importance because of the highly virulent nature of certain strains of this ..
  37. ncbi A vaccine candidate of attenuated genotype VII Newcastle disease virus generated by reverse genetics
    Shunlin Hu
    Animal Infectious Disease Laboratory, Yangzhou University, Yangzhou, Jiangsu 225009, China
    Vaccine 27:904-10. 2009
    Genotype VII Newcastle disease virus (NDV) has been documented as the predominant epidemic genotype in China and some other Asian countries since 1990s...
  38. ncbi Generation of a recombinant chimeric Newcastle disease virus vaccine that allows serological differentiation between vaccinated and infected animals
    B P Peeters
    Department of Avian Virology, Institute for Animal Science and Health ID Lelystad, P O Box 65, 8200 AB, Lelystad, The Netherlands
    Vaccine 19:1616-27. 2001
    Using a recently developed reverse genetics system, we have generated a recombinant Newcastle disease virus (NDV) vaccine in which the gene encoding the hemagglutinin-neuraminidase (HN) has been replaced by a hybrid HN gene consisting of ..
  39. pmc Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia
    Scott J Goebel
    Divisions of Infectious Disease and Molecular Medicine, David Axelrod Institute, Wadsworth Center, NYSDOH, Albany, NY 12201 2002, USA
    J Virol 81:12709-14. 2007
    ..method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections...
  40. ncbi Protective dose of a recombinant Newcastle disease LaSota-avian influenza virus H5 vaccine against H5N2 highly pathogenic avian influenza virus and velogenic viscerotropic Newcastle disease virus in broilers with high maternal antibody levels
    David Sarfati-Mizrahi
    Laboratorio Avi Mex, SA de CV, Bartolache 1862, Colonia del Valle, 01900, Mexico, D F Mexico
    Avian Dis 54:239-41. 2010
    The protective dose of a live recombinant LaSota Newcastle disease virus (NDV)-avian influenza H5 vaccine (rNDV-LS/AI-H5) was determined in broiler chickens with high levels of maternal antibodies against NDV and avian influenza virus (..
  41. ncbi Virulent Newcastle disease virus elicits a strong innate immune response in chickens
    Cary A Rue
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    J Gen Virol 92:931-9. 2011
    b>Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry worldwide...
  42. ncbi Control of Newcastle disease by vaccination
    D A Senne
    U S Department of Agriculture, Animal and Plant Health Inspection Service, National Veterinary Services Laboratories, Ames, Iowa 50010, USA
    Dev Biol (Basel) 119:165-70. 2004
    Vaccination for Newcastle disease (ND) is routinely practised in countries where virulent strains of the Newcastle disease virus (NDV) are endemic and in countries where virulent strains do not exist but ill-timed infection by a low ..
  43. ncbi Effects of Newcastle disease virus vaccine antibodies on the shedding and transmission of challenge viruses
    Patti J Miller
    Exotic and Emerging Avian Disease Research Unit, Southeast Poultry Research Laboratory, Agricultural Research Service, USDA, 934 College Station Road, Athens, GA, United States Electronic address
    Dev Comp Immunol 41:505-13. 2013
    ..Traditionally, Newcastle disease virus (NDV) is recognized as having two major divisions represented by classes I and II, with class II being ..
  44. ncbi Complete genome characterisation of a Newcastle disease virus isolated during an outbreak in Sweden in 1997
    Anna Malin Linde
    Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, Swedish University of Agricultural Sciences SLU, Ulls Väg 2B, Uppsala, Sweden
    Virus Genes 41:165-73. 2010
    The complete genome sequence of a Newcastle disease virus (NDV) isolated from a chicken in Sweden was determined and compared with other NDV sequences...
  45. ncbi Rapid detection and differentiation of Newcastle disease virus by real-time PCR with melting-curve analysis
    H M Pham
    Department of Disease Control, Laboratory of Infectious Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Arch Virol 150:2429-38. 2005
    In order to rapidly detect and differentiate Newcastle disease virus (NDV) isolates, a method based on real-time PCR SYBR Green I melting-curve analysis of the fusion (F) protein gene was developed...
  46. ncbi Pathologic and immunohistochemical studies of Newcastle disease (ND) in broiler chickens vaccinated with ND: severe nonpurulent encephalitis and necrotizing pancreatitis
    K Nakamura
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Vet Pathol 45:928-33. 2008
    Twenty-five 22- to 46-day-old broilers with Newcastle disease (ND) were investigated pathologically and immunohistochemically in order to evaluate the mechanism of ND outbreak in vaccinated broilers...
  47. ncbi Goose RIG-I functions in innate immunity against Newcastle disease virus infections
    Yingjie Sun
    Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, PR China
    Mol Immunol 53:321-7. 2013
    ..retinoic acid-inducible gene I (RIG-I) is a chief antiviral gene sensing viral RNA molecules including Newcastle disease virus (NDV). In this study, goose RIG-I gene (gRIG-I) was identified...
  48. pmc Characterization of newly emerging Newcastle disease virus isolates from the People's Republic of China and Taiwan
    L Yu
    Animal Health Biotechnology Laboratory, Institute of Molecular Agrobiology, National University of Singapore, Singapore 117604
    J Clin Microbiol 39:3512-9. 2001
    Seven Newcastle disease (ND) virus (NDV) isolates which were recovered from ND outbreaks in chicken and pigeon flocks in China and Taiwan between 1996 and 2000 were genotypically and pathotypically characterized...
  49. ncbi Systematic selection of housekeeping genes for gene expression normalization in chicken embryo fibroblasts infected with Newcastle disease virus
    Renfu Yin
    Department of Veterinary Preventive Medicine, College of Animal Science and Veterinary Medicine, Jilin University, Xi an Road 5333, Changchun, Jilin 130062, China
    Biochem Biophys Res Commun 413:537-40. 2011
    ..Our study emphasizes that even the most popular HKGs like 18S RNA and GAPDH can lead to divergent and inaccurate data interpretation of significant magnitude if not carefully analyzed for stability before...
  50. pmc Avian paramyxovirus serotypes 2-9 (APMV-2-9) vary in the ability to induce protective immunity in chickens against challenge with virulent Newcastle disease virus (APMV-1)
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Vaccine 30:2220-7. 2012
    ..b>Newcastle disease virus (NDV), which constitutes serotype 1 (APMV-1), is an important pathogen of poultry, but the pathogenic ..
  51. pmc Preparation and efficacy of a live newcastle disease virus vaccine encapsulated in chitosan nanoparticles
    Kai Zhao
    Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin, China
    PLoS ONE 7:e53314. 2012
    b>Newcastle disease (ND) is a highly contagious viral disease of poultry caused by pathogenic strains of the Newcastle disease virus (NDV). Live NDV vaccines are administered by drinking water, eyedrops or coarse aerosol spray...
  52. pmc Characterization of a recombinant Newcastle disease virus vaccine strain
    Sun Hee Cho
    Zoonotic Disease Institute, Seoul National University, San 56 1, Shillim Dong, Gwanak Gu, Seoul, Korea
    Clin Vaccine Immunol 15:1572-9. 2008
    ..Therefore, KBNP-C4152R2L is a promising vaccine strain and viral vector in terms of antigenicity, productivity, safety, and pathogenic stability...
  53. pmc Biological and phylogenetic characterization of a genotype VII Newcastle disease virus from Venezuela: efficacy of field vaccination
    Francisco Perozo
    College of Veterinary Medicine, University of Zulia, Maracaibo, Venezuela
    J Clin Microbiol 50:1204-8. 2012
    Here we report the biological and molecular characterization of a virulent genotype VII Newcastle disease virus (NDV) circulating in Venezuela and the assessment of the vaccination efficacy under field conditions compared to controlled ..
  54. pmc Phylogenetic and pathotypical analysis of two virulent Newcastle disease viruses isolated from domestic ducks in China
    Shouping Zhang
    Key Laboratory of Animal Epidemiology and Zoonosis, College of Veterinary Medicine, Ministry of Agriculture, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 6:e25000. 2011
    Two velogenic Newcastle disease viruses (NDV) obtained from outbreaks in domestic ducks in China were characterized in this study...
  55. ncbi Pathogenicity and immunogenicity of different recombinant Newcastle disease virus clone 30 variants after in ovo vaccination
    Kristina Ramp
    Institute of Molecular Biology, Südufer 10, D 17493 Greifswald Insel Riems, Germany
    Avian Dis 56:208-17. 2012
    Even though Newcastle disease virus (NDV) live vaccine strains can be applied to 1-day-old chickens, they are pathogenic to chicken embryos when given in ovo 3 days before hatch...
  56. pmc Genomic and biological characterization of a velogenic Newcastle disease virus isolated from a healthy backyard poultry flock in 2010
    Muhammad Munir
    Division of Virology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, SLU, Ulls Väg 2B, 751 89 Uppsala, Sweden
    Virol J 9:46. 2012
    b>Newcastle disease virus (NDV) causes severe and economically important disease in poultry around the globe. None of NDV strains in Pakistan have been completely characterized and the role of rural poultry in harbouring NDV is unclear...
  57. pmc Evaluating viral interference between Influenza virus and Newcastle disease virus using real-time reverse transcription-polymerase chain reaction in chicken eggs
    Shengqiang Ge
    Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
    Virol J 9:128. 2012
    ..allantoic cavity inoculations of Specific-pathogen-free (SPF) chicken eggs with Influenza virus (AIV) and Newcastle disease virus (NDV) demonstrated that the interaction of AIV and NDV during co-infection was variable...
  58. ncbi Characteristics of pigeon paramyxovirus serotype-1 isolates (PPMV-1) from the Russian Federation from 2001 to 2009
    I P Pchelkina
    Federal Governmental Institution, Federal Centre for Animal Health, FGI ARRIAH, Vladimir 600901, Russia
    Avian Dis 57:2-7. 2013
    ..It was determined that most of these Newcastle disease virus isolates (70/77) recovered from the pigeons belonged to a relatively poorly studied sublineage VIb/2...
  59. pmc A majority of infectious Newcastle disease virus particles contain a single genome, while a minority contain multiple genomes
    Peter H Goff
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    J Virol 86:10852-6. 2012
    ..A quantitative approach to paramyxovirus packaging revealed a majority of infectious Newcastle disease viruses contain one functional genome...
  60. pmc High genetic diversity of Newcastle disease virus in poultry in West and Central Africa: cocirculation of genotype XIV and newly defined genotypes XVII and XVIII
    Chantal J Snoeck
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Luxembourg
    J Clin Microbiol 51:2250-60. 2013
    Despite rampant Newcastle disease virus (NDV) outbreaks in Africa for decades, the information about the genetic characteristics of the virulent strains circulating in West and Central Africa is still scarce...
  61. ncbi Newcastle disease: a review of field recognition and current methods of laboratory detection
    Giovanni Cattoli
    Istituto Zooprofilattico Sperimentale delle Venezie, Research and Development Department, Viale dell Università10 35020 Legnaro PD, Italy
    J Vet Diagn Invest 23:637-56. 2011
    b>Newcastle disease (ND) remains a constant threat to the poultry industry and is a limiting disease for poultry producers worldwide...
  62. pmc Complete genome and clinicopathological characterization of a virulent Newcastle disease virus isolate from South America
    Diego G Diel
    USDA, ARS, Southeast Poultry Research Laboratory, Athens, Georgia, USA
    J Clin Microbiol 50:378-87. 2012
    b>Newcastle disease (ND) is one of the most important diseases of poultry, negatively affecting poultry production worldwide...
  63. pmc Entire genome sequence analysis of genotype IX Newcastle disease viruses reveals their early-genotype phylogenetic position and recent-genotype genome size
    Xusheng Qiu
    Key Laboratory of Animal Infectious Diseases, Yangzhou University, Yangzhou 225009, PR China
    Virol J 8:117. 2011
    ..However, F48-like NDVs from China, identified a 6-nt insert in the NP gene, have been previously classified into genotype III or genotype IX...
  64. pmc Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutininneuraminidase proteins
    Youn Jeong Lee
    National Veterinary Research and Quarantine Service, Anyang 430 824, Korea
    J Vet Sci 9:301-8. 2008
    ..the fusion (F) and hemagglutinin-neuraminidase (HN) glycoprotein gene of the viscerotropic velogenic (vv) Newcastle disease virus (NDV) isolate, Kr-005/00, and a lentogenic La Sota strain of the NDV were constructed in an attempt to ..
  65. ncbi Whole genome sequencing and characterization of a virulent Newcastle disease virus isolated from an outbreak in Sweden
    Muhammad Munir
    The Department of Biomedical Sciences and Veterinary Public Health, Division of Virology and Parasitology and Joint Research and Development, National Veterinary Institute SVA, Uppsala, Sweden
    Virus Genes 43:261-71. 2011
    In this study, the complete genome sequence of a Newcastle disease virus (NDV) isolate collected from an outbreak in 1995 in chickens was fully characterized and compared with other NDV sequences...
  66. ncbi Newcastle disease in geese: natural occurrence and experimental infection
    Hongquan Wan
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Jiangsu, China
    Avian Pathol 33:216-21. 2004
    ..Velogenic Newcastle disease (ND) viruses were isolated from visceral organs and cloacal swabs of diseased birds in the field...
  67. ncbi Sulfated modification can enhance the adjuvanticity of lentinan and improve the immune effect of ND vaccine
    Zhenhuan Guo
    Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China
    Vaccine 27:660-5. 2009
    The purpose of this research is to study the effect of sulfated lentinan (sLNT) on immune effect of Newcastle disease (ND) vaccine...
  68. ncbi Adjuvant effects of chicken interleukin-18 in avian Newcastle disease vaccine
    Li Hsiang Hung
    Department of Veterinary Medicine, National Pingtung University of Science and Technology, 1, Hseuh Fu Road, Neipu, Pingtung 912, Taiwan, ROC
    Vaccine 28:1148-55. 2010
    ..Vaccination with cell-cultured Newcastle disease vaccine (NDTC) co-administrated with pCHIL18-F, pCHIL18-M or euCHIL18 resulted in significant increments of ..
  69. pmc Protective efficacy of commercial inactivated Newcastle disease virus vaccines in chickens against a recent Korean epizootic strain
    Woo Jin Jeon
    Avian Disease Division, National Veterinary Research Institute, National Veterinary Research and Quarantine Service, Anyang 430 824, Korea
    J Vet Sci 9:295-300. 2008
    Despite the intensive vaccination policy that has been put in place to control Newcastle disease virus (NDV), the recent emergence of NDV genotype VII strains in Korea has led to significant economic losses in the poultry industry...
  70. ncbi Complete genome analysis of an avian paramyxovirus type 1 strain isolated in 1994 from an asymptomatic black-headed gull (Larus ridibundus) in southern Sweden
    Muhammad Munir
    Joint Research and Development Unit for Virology, Immunobiology and Parasitology of the National Veterinary Institute SVA and Swedish University of Agricultural Sciences SLU, Department of Biomedical Sciences and Veterinary Public Health, Division of Microbiology and Food Safety, Ulls Väg 2B, SE 751 89 Uppsala, Sweden
    Avian Dis 54:923-30. 2010
    ..Waterfowl have been considered to act as a reservoir for APMV-1 and, therefore, it is important to broaden the knowledge of viruses circulating within this population...
  71. ncbi Clinicopathological characterization in poultry of three strains of Newcastle disease virus isolated from recent outbreaks
    L Susta
    Department of Veterinary Pathology, CVM, UGA, Athens, GA 30602 7388, USA
    Vet Pathol 48:349-60. 2011
    b>Newcastle disease is a severe threat to the poultry industry and is caused by Newcastle disease virus, a member of the genus Avulavirus, family Paramyxoviridae...
  72. ncbi Pathogenesis of six pigeon-origin isolates of Newcastle disease virus for domestic chickens
    G D Kommers
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602 7388, USA
    Vet Pathol 39:353-62. 2002
    The pathogenesis of six pigeon-origin isolates of Newcastle disease virus (NDV) was investigated in chickens...
  73. ncbi Effect of probe-site mismatches on detection of virulent Newcastle disease viruses using a fusion-gene real-time reverse transcription polymerase chain reaction test
    L Mia Kim
    USDA, Agricultural Research Service, Southeast Poultry Research Laboratory, Athens GA 30605, USA
    J Vet Diagn Invest 18:519-28. 2006
    Virulent forms of Newcastle disease virus (NDV) are a major concern for poultry producers around the world and the rapid diagnosis of an outbreak is crucial to any control program...
  74. ncbi Aflatoxicosis, infectious bursal disease and immune response to Newcastle disease vaccination in rural chickens
    Maxwell O Otim
    Livestock Health Research Institute, LIRI, P O Box 96, Tororo, Uganda
    Avian Pathol 34:319-23. 2005
    ..effects of infectious bursal disease virus (IBDV) and aflatoxin in indigenous chickens of Uganda, Newcastle disease (ND) seronegative chicks were randomly allocated to two treatment groups...
  75. ncbi Pathogenesis of chicken-passaged Newcastle disease viruses isolated from chickens and wild and exotic birds
    Glaucia D Kommers
    Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D W Brooks Drive, Athens, GA 30602 7388, USA
    Avian Dis 47:319-29. 2003
    The pathogenesis of six Newcastle disease virus (NDV) isolates recovered from chickens (Ckn-LBM and Ckn-Australia) and wild (Anhinga) and exotic (YN parrot, pheasant, and dove) birds was examined after the isolates had been passaged four ..
  76. pmc The viral replication complex is associated with the virulence of Newcastle disease virus
    J C F M Dortmans
    Central Veterinary Institute of Wageningen UR, Lelystad, Netherlands
    J Virol 84:10113-20. 2010
    Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the ..
  77. ncbi The pathogenesis of Newcastle disease: a comparison of selected Newcastle disease virus wild-type strains and their infectious clones
    Nobuko Wakamatsu
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, GA 30605, USA
    Virology 353:333-43. 2006
    The effect of mutations of Newcastle disease virus (NDV) fusion (F) gene, hemagglutinin-neuraminidase (HN) gene, and phosphoprotein (P) gene and HN chimeras between the virulent Beaudette C and low virulence LaSota strains on ..
  78. ncbi Genotyping of Newcastle disease viruses isolated from 2001 to 2007 in Japan
    Masaji Mase
    National Institute of Animal Health, Ibaraki, Japan
    J Vet Med Sci 71:1101-4. 2009
    Seventeen isolates of Newcastle disease virus (NDV) were obtained from various prefectures in Japan during the years 2001-2007 and were genotypically analyzed by the reverse transcriptase-polymerase chain reaction (RT-PCR) method coupled ..
  79. ncbi Virulence of pigeon-origin Newcastle disease virus isolates for domestic chickens
    G D Kommers
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602-7388, USA
    Avian Dis 45:906-21. 2001
    The virulence of six pigeon-origin isolates of Newcastle disease virus (NDV) was evaluated before and after passage in white leghorn chickens...
  80. ncbi Ultrastructural changes of the tracheal epithelium after vaccination of day-old chickens with the La Sota strain of Newcastle disease virus
    J Mast
    Veterinary and Agrochemical Research Center, Brussels, Belgium
    Vet Pathol 42:559-65. 2005
    ..tracheal lesions induced by vaccination of day-old specific pathogen-free chicks with the La Sota strain of Newcastle disease virus (NDV) was examined by relating surface changes as observed by scanning electron microscopy with ..
  81. ncbi Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence
    J C F M Dortmans
    Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    J Gen Virol 92:336-45. 2011
    Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals...
  82. pmc Characterization of class I Newcastle disease virus isolates from Hong Kong live bird markets and detection using real-time reverse transcription-PCR
    L Mia Kim
    Southeast Poultry Research Laboratory, USDA ARS, 934 College Station Rd, Athens, GA 30605, USA
    J Clin Microbiol 45:1310-4. 2007
    b>Newcastle disease viruses isolated from Hong Kong live bird markets (LBMs) were not detected by a USDA-validated matrix gene real-time reverse transcription-PCR (RT-PCR) assay...
  83. ncbi Identification of a variable epitope on the Newcastle disease virus hemagglutinin-neuraminidase protein
    Shunlin Hu
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, 48 East Wenhui Road, Yangzhou 225009, China
    Vet Microbiol 140:92-7. 2010
    Fifteen virulent Newcastle disease viruses (NDVs) were isolated from diseased birds in Eastern China in 2005...
  84. pmc Loop-mediated isothermal amplification for rapid detection of Newcastle disease virus
    Hang Minh Pham
    Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Clin Microbiol 43:1646-50. 2005
    ..on the loop-mediated isothermal amplification (LAMP) assay for the rapid, simple, and sensitive detection of Newcastle disease virus (NDV) directly from culture isolates as well as clinical samples...
  85. ncbi Simultaneous detection and differentiation of Newcastle disease and avian influenza viruses using oligonucleotide microarrays
    Lih Chiann Wang
    Graduate Institute of Veterinary Medicine, National Taiwan University, 1 Sec 4, Roosevelt Road, Taipei 106, Taiwan
    Vet Microbiol 127:217-26. 2008
    b>Newcastle disease (ND) and avian influenza (AI) are two of the most important zoonotic viral diseases of birds throughout the world. These two viruses often have a great impact upon the poultry industry...
  86. ncbi Genetic parameters for body weights, egg traits and antibody response against Newcastle Disease Virus (NDV) vaccine among two Tanzania chicken ecotypes
    J Lwelamira
    Institute of Rural Development Planning, P O Box 138, Dodoma, Tanzania
    Trop Anim Health Prod 41:51-9. 2009
    ..The magnitudes of heritability estimates obtained in this study indicate good prospects of improving these traits in both ecotypes through selection...
  87. ncbi Pathotypical and genotypical characterization of strains of Newcastle disease virus isolated from outbreaks in chicken and goose flocks in some regions of China during 1985-2001
    X F Liu
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China
    Arch Virol 148:1387-403. 2003
    Twenty-nine strains of Newcastle disease virus (NDV) isolated from outbreaks in chicken and goose flocks in several regions of China during 1985-2001 were characterized pathotypically and genotypically...
  88. ncbi Surveillance for avirulent Newcastle disease viruses in domestic ducks (Anas platyrhynchos and Cairina moschata) at live bird markets in Eastern China and characterization of the viruses isolated
    Xiaowen Liu
    Key Laboratory of Animal Infectious Diseases of Ministry of Agriculture, School of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China
    Avian Pathol 38:377-91. 2009
    We isolated and identified 201 Newcastle disease viruses (NDVs) from domestic ducks in a 5-year surveillance study at live bird markets in Eastern China. Seventy-three of these isolates were characterized biologically and genetically...
  89. ncbi High-level expression of a foreign gene from the most 3'-proximal locus of a recombinant Newcastle disease virus
    Z Huang
    Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Gen Virol 82:1729-36. 2001
    ..chloramphenicol acetyltransferase (CAT) between the HN and L genes of the full-length cDNA of a virulent Newcastle disease virus (NDV) yielded virus with growth retardation and attenuation...
  90. ncbi Newcastle disease virus in West Africa: new virulent strains identified in non-commercial farms
    Chantal J Snoeck
    National Public Health Laboratory, Institute of Immunology, 20A rue Auguste Lumière, 1950, Luxembourg, Luxembourg
    Arch Virol 154:47-54. 2009
    Forty-four Newcastle disease virus (NDV) strains, obtained between 2002 and 2007 from different poultry species in Nigeria, Niger, Burkina Faso and Cameroon, were phylogenetically analysed based on partial F sequences...
  91. ncbi Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens
    Yu Shengqing
    Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, 680 8553, Japan
    Virology 301:206-11. 2002
    A benign Newcastle disease virus (NDV) recently became highly virulent during replication in domestic chickens...
  92. ncbi Newcastle disease virus-induced cytopathic effect in infected cells is caused by apoptosis
    P V Ravindra
    Molecular Biology Laboratory, Division of Animal Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122 UP, India
    Virus Res 141:13-20. 2009
    The velogenic Newcastle disease virus (NDV) causes highly infectious and economically significant Newcastle disease (ND) in birds of various species...
  93. ncbi Avian influenza and Newcastle disease viruses from northern pintail in Japan: isolation, characterization and inter-annual comparisons during 2006-2008
    Alam Jahangir
    Laboratory of Zoonoses, School of Veterinary Medicine, Kitasato University, 35 1 Higasi, 23 Bancho, Towadashi, Aomori, 034 8628, Japan
    Virus Res 143:44-52. 2009
    ..We also provide evidence that this host carries APMV-1: Newcastle disease virus (NDV) and other haemagglutinating viruses...
  94. pmc Engineered viral vaccine constructs with dual specificity: avian influenza and Newcastle disease
    Man Seong Park
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:8203-8. 2006
    Avian influenza viruses of the H5 and H7 hemagglutinin subtypes, and Newcastle disease virus (NDV), are important pathogens in poultry worldwide...
  95. pmc The hemagglutinin-neuraminidase protein of Newcastle disease virus determines tropism and virulence
    Zhuhui Huang
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 78:4176-84. 2004
    The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) plays a crucial role in the process of infection. However, the exact contribution of the HN gene to NDV pathogenesis is not known...
  96. ncbi Genomic sequences of low-virulence avian paramyxovirus-1 (Newcastle disease virus) isolates obtained from live-bird markets in North America not related to commonly utilized commercial vaccine strains
    Bruce S Seal
    Southeast Poultry Research Laboratory, U S Department of Agriculture, Agricultural Research Service, 934 College Station Road, Athens, GA 360605, USA
    Vet Microbiol 106:7-16. 2005
    Avian paramyxovirus 1 (APMV-1), also referred to as Newcastle disease virus (NDV), variants of low virulence were isolated from chickens, ducks and other unidentified species found in live-bird markets of the northeastern United States...
  97. pmc Phylogenetic diversity among low-virulence newcastle disease viruses from waterfowl and shorebirds and comparison of genotype distributions to those of poultry-origin isolates
    L Mia Kim
    USDA ARS SouthEast Poultry Research Laboratory, Athens, GA 30605, USA
    J Virol 81:12641-53. 2007
    Low-virulence Newcastle disease viruses (loNDV) are frequently recovered from wild bird species, but little is known about their distribution, genetic diversity, or potential to cause disease in poultry...
  98. pmc A combination in-ovo vaccine for avian influenza virus and Newcastle disease virus
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Vaccine 26:522-31. 2008
    The protection of poultry from H5N1 highly pathogenic avian influenza A (HPAI) and Newcastle disease virus (NDV) can be achieved through vaccination, as part of a broader disease control strategy...
  99. ncbi Virulence of pigeon paramyxovirus type 1 does not always correlate with the cleavability of its fusion protein
    J C F M Dortmans
    Central Veterinary Institute CVI of Wageningen UR, Lelystad, The Netherlands
    J Gen Virol 90:2746-50. 2009
    ..By using reverse genetics, we exchanged the F genes of AV324 and a virulent Newcastle disease virus (NDV) strain (Herts) and evaluated the recovered chimeric viruses for their pathogenicity in 1-day-old ..
  100. ncbi Complete genome sequence of a virulent Newcastle disease virus isolated from an outbreak in chickens in Egypt
    Mahmoud H A Mohamed
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Genes 39:234-7. 2009
    The complete genome sequence of a virulent Newcastle disease virus (NDV) isolated from chickens in Egypt was determined and compared to the sequence of NDV strains isolated from different parts of the world...
  101. ncbi Molecular characterization and phylogenetic analysis of new Newcastle disease virus isolates from the mainland of China
    Hualei Liu
    National Reference Laboratory for Newcastle Disease, China Animal Health and Epidemiology Center, Qingdao 266032, China
    Res Vet Sci 85:612-6. 2008
    Seventy-nine velogenic Newcastle disease virus (NDV) isolates were obtained from infected chicken flocks during the outbreaks of Newcastle disease (ND) in various regions of the mainland of China in 2006...

Research Grants26

  1. STRUCTURE AND EXPRESSION OF THE PARAMYXOVIRUS SV5 GENOME
    Robert A Lamb; Fiscal Year: 2010
    ..virus type 1 (hPIV1), type 2, type 3, type 5 (also know as simian virus 5 [SV5]), Sendai virus, Newcastle disease virus, measles virus, canine distemper virus, rinderpest virus, respiratory syncytial virus, human ..
  2. Newcastle Disease Virus Vectored Vaccines for Norovirus Infection
    Siba K Samal; Fiscal Year: 2013
    ..To overcome these obstacles, live vectored vaccine can be an attractive approach. Newcastle disease virus (NDV), an avian paramyxovirus, vectored vaccines have shown encouraging results for vaccinations ..
  3. MODULATION OF INNATE AND ADAPTIVE IMMUNITY BY DENGUE VIRUS
    Ana Fernandez-Sesma; Fiscal Year: 2012
    ..We will generate recombinant Newcastle disease virus (NDV) expressing individual DenV proteins and will infect DCs and other blood APCs...
  4. Phase I Clinical Translation Trial of Oncolytic rVSV-F Virotherapy for HCC
    Savio L Woo; Fiscal Year: 2010
    ..constructed a recombinant VSV that expresses a genetically modified fusogenic membrane glycoprotein of the Newcastle disease virus (rVSV-F) and showed that through hepatic artery infusion, it infected and replicated extensively in ..
  5. NDV-vectored Lyme disease vaccines
    Siba K Samal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We propose to evaluate the use of the Newcastle disease virus (NDV) as a delivery vector for host immunization with borrelial antigens as vaccine targets...
  6. Newcastle disease virus vectored HIV vaccines
    Siba K Samal; Fiscal Year: 2013
    ..We have chosen to use APMV-1, also known as Newcastle disease virus (NDV), because this is the most studied member among APMVs...
  7. A Novel Approach to RSV Vaccination
    Joan E Durbin; Fiscal Year: 2013
    ..In a new approach to RSV vaccine design we made use of a viral vector derived from an avian paramyxovirus, Newcastle disease virus (NDV), chosen because it is known to be a very strong trigger for IFN-α/βproduction ..
  8. RSV Upper Airway Infection and Otitis Media
    JOAN E contact DURBIN; Fiscal Year: 2010
    ..models of RSV upper airway infection, and have used these to test a new RSV vaccine candidate: a recombinant Newcastle disease virus vector expressing the RSV F protein...
  9. Activation and Inhibition of Apoptotic Pathways by SV5
    Biao He; Fiscal Year: 2007
    ..important human and animal pathogens such as respiratory syncytial virus, measles virus, imumps virus and Newcastle disease virus...
  10. MOLECULAR BIOLOGY OF NDV MEMBRANE PROTEINS
    RONALD IORIO; Fiscal Year: 1993
    b>Newcastle disease virus (NDV) is the model for important, but difficult to study paramyxoviruses like measles, mumps, and respiratory syncytial viruses...
  11. CYTOKINE GENE EXPRESSION BY VIRUS IN GLIAL CELLS
    MOON SHIN; Fiscal Year: 2000
    ..We will use Newcastle Disease virus (NDV) and measles virus (MV)...
  12. Prime/Boost Immunization against HIV-1 by Viral Vectors
    Matthias Schnell; Fiscal Year: 2003
    ..attenuated, replication-competent rabies virus (RV), influenza A virus (FluA), and replication-deficient Newcastle disease virus (NDV)...
  13. MOLECULAR GENETICS OF INTESTINAL DEVELOPMENT
    Jeffrey Gordon; Fiscal Year: 1999
    ..by expressing (i) influenza C virus 9-0-acetyl-5-N-acetyl-neuraminic acid-specific esterase, the Newcastle Disease virus N-acetyl-neuraminidase (sialidase) a human alpha1,2 specific fucosyltransferase, and a human alpha1,3/..
  14. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2005
    ..The goal of our studies is to understand the molecular mechanisms of paramyxovirus membrane fusion using Newcastle disease virus as a prototype. As in most paramyxovirus systems, membrane fusion requires both HN and F proteins...
  15. Paramyxovirus Entry
    TRUDY MORRISON; Fiscal Year: 2001
    The goal of our studies is to understand the molecular mechanisms of paramyxovirus membrane fusion using Newcastle disease virus as a prototype. As in most paramyxovirus systems, membrane fusion requires both HN and F proteins...
  16. NDV INFECTION: ANALYSIS AT THE SUBCELLULAR LEVEL
    Lawrence Hightower; Fiscal Year: 1980
    ..cultivated chicken embryo cells by temperature-sensitive and noncytopathic mutants of a virulent strain of Newcastle disease virus...
  17. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    ADAM VIGIL; Fiscal Year: 2006
    In this proposal, the outlined experiments aim at providing an integrated view of the oncolytic potential of Newcastle Disease Virus and the elicited host immune response as an important player in tumor therapy...
  18. NEUTRALIZATION OF NDV BY MONOCLONAL ANTIBODIES
    RONALD IORIO; Fiscal Year: 1991
    Previous work suggests that neutralization of Newcastle disease virus (NDV) by a panel of monoclonal antibodies (MAbs) specific for its HN glycoprotein requires the addition of MAbs to four sites having different functional inhibition ..
  19. TLRs in Innate Immunity to Viral Infection
    Robert Finberg; Fiscal Year: 2006
    ..we will define the pathophysiology of the innate immune response to RSV and other viral pathogens, including Newcastle disease virus and polyoma virus...
  20. TARGETING ANGIOGENESIS WITH PROTEASE ACTIVATABLE VECTORS
    Stephen Russell; Fiscal Year: 2002
    ..abstract_text> ..
  21. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  22. Protease Activation of Newcastle Disease Virus for Oncolytic viral therapy
    ELANKUMARAN SUBBIAH; Fiscal Year: 2008
    ..therapeutic strategies in vogue largely rely upon the natural tumor selectivity of certain viruses, such as Newcastle disease virus (NDV), and Vesicular stomatitis virus (VSV)...
  23. HTS for Small Molecule Modulators of EB Virus Protein-Protein Interactions
    Theodore Jardetzky; Fiscal Year: 2007
    ..The proposed research will allow for the identification of inhibitors of the virus entry into cells, potentially opening up new therapeutic routes to preventing EBV infection and transformation of susceptible human cells. [unreadable]..
  24. Nipah Virus Marker Vaccine and Companion Diagnostic Test
    James Roth; Fiscal Year: 2005
    ..abstract_text> ..
  25. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..