theileriasis

Summary

Summary: Infection of cattle, sheep, or goats with protozoa of the genus THEILERIA. This infection results in an acute or chronic febrile condition.

Top Publications

  1. ncbi Detection of haemoparasites in cattle by reverse line blot hybridisation with a note on the distribution of ticks in Sicily
    K Georges
    Division of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.165, 3508 TD Utrecht, The Netherlands
    Vet Parasitol 99:273-86. 2001
  2. ncbi Reverse line blot hybridization used to identify hemoprotozoa in Minorcan cattle
    Sonia Almeria
    Parasitology, Department of Animal Health, Veterinary School, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Ann N Y Acad Sci 969:78-82. 2002
  3. ncbi Discrimination between Theileria lestoquardi and Theileria annulata in their vectors and hosts by RFLP based on the 18S rRNA gene
    Eva Spitalska
    School of Agriculture, Food and Rural Development, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
    Parasitol Res 94:318-20. 2004
  4. ncbi Epidemiological studies on tick-borne diseases of cattle in Central Equatoria State, Southern Sudan
    D A Salih
    Central Veterinary Research Laboratories, Al Amarat, PO Box 8067, Khartoum, Sudan
    Parasitol Res 101:1035-44. 2007
  5. ncbi Sequence heterogeneity in the 18S rRNA gene within Theileria equi and Babesia caballi from horses in South Africa
    Raksha Bhoora
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    Vet Parasitol 159:112-20. 2009
  6. ncbi Application of a reverse line blot assay to the study of haemoparasites in cattle in Uganda
    C A L Oura
    Department of Microbiology and Parasitology, Faculty of Vet Medicine, Makerere University, Kampala, Uganda
    Int J Parasitol 34:603-13. 2004
  7. ncbi An outbreak of haemolytic anaemia associated with infection of Theileria orientalis in naive cattle
    A M J McFadden
    Investigation and Diagnostic Centre, Wallaceville, Biosecurity New Zealand, Ministry of Agriculture and Forestry, Upper Hutt 5018, New Zealand
    N Z Vet J 59:79-85. 2011
  8. ncbi A longitudinal study of disease incidence and case-fatality risks on small-holder dairy farms in coastal Kenya
    S H Maloo
    Kenya Agricultural Research Institute, P.O. Box 10275, Bamburi (Mombasa, Kenya
    Prev Vet Med 52:17-29. 2001
  9. ncbi Epidemiological analysis of tick-borne diseases in Zambia
    Martin Simuunza
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Vet Parasitol 175:331-42. 2011
  10. ncbi c-Jun NH2-terminal kinase/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria
    Regina Lizundia
    Institut Cochin, Departement de Maladies Infectieuses, Paris, France
    Cancer Res 66:6105-10. 2006

Research Grants

  1. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
  2. EIAV Control by High Avidity Rev-Specific CTL Clones
    ROBERT MEALEY; Fiscal Year: 2005
  3. EIAV Control by DNA Vaccine-Induced CTL
    ROBERT MEALEY; Fiscal Year: 2006
  4. GENETIC DISSECTION OF TOXOPLASMA GONDII
    David Roos; Fiscal Year: 2008

Detail Information

Publications211 found, 100 shown here

  1. ncbi Detection of haemoparasites in cattle by reverse line blot hybridisation with a note on the distribution of ticks in Sicily
    K Georges
    Division of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.165, 3508 TD Utrecht, The Netherlands
    Vet Parasitol 99:273-86. 2001
    ..lusitanicum, Rhipicephalus sanguineus group, R. bursa, Dermacentor marginatus, Haemaphysalis punctata, B. annulatus and I. ricinus...
  2. ncbi Reverse line blot hybridization used to identify hemoprotozoa in Minorcan cattle
    Sonia Almeria
    Parasitology, Department of Animal Health, Veterinary School, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Ann N Y Acad Sci 969:78-82. 2002
    ..annulata. The RLB was highly sensitive and allowed the simultaneous detection and identification of the Theileria and Babesia species in carrier cattle, which cannot be achieved by classical identification methods...
  3. ncbi Discrimination between Theileria lestoquardi and Theileria annulata in their vectors and hosts by RFLP based on the 18S rRNA gene
    Eva Spitalska
    School of Agriculture, Food and Rural Development, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
    Parasitol Res 94:318-20. 2004
    ..However, we developed a species-specific RFLP test based on the MspI restriction enzyme, able to cut amplified products from T. lestoquardi only and to discriminate the two species in both tick and blood samples...
  4. ncbi Epidemiological studies on tick-borne diseases of cattle in Central Equatoria State, Southern Sudan
    D A Salih
    Central Veterinary Research Laboratories, Al Amarat, PO Box 8067, Khartoum, Sudan
    Parasitol Res 101:1035-44. 2007
    ..The highest prevalence of Theileria parva was reported in the rainy season (October). The implications of these results on the epidemiology of tick-borne diseases are discussed with emphasis on East Coast fever...
  5. ncbi Sequence heterogeneity in the 18S rRNA gene within Theileria equi and Babesia caballi from horses in South Africa
    Raksha Bhoora
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    Vet Parasitol 159:112-20. 2009
    ..caballi is required prior to the development of molecular diagnostic tests to detect these parasites in horses. Species-specific probes must be in designed in regions of the gene that are both conserved within and unique to each species...
  6. ncbi Application of a reverse line blot assay to the study of haemoparasites in cattle in Uganda
    C A L Oura
    Department of Microbiology and Parasitology, Faculty of Vet Medicine, Makerere University, Kampala, Uganda
    Int J Parasitol 34:603-13. 2004
    ..mutans and possibly T. taurotragi and T. velifera, may also cause clinical disease. Overall, the results presented here highlight the complexity of tick-borne pathogen infections in cattle in Uganda...
  7. ncbi An outbreak of haemolytic anaemia associated with infection of Theileria orientalis in naive cattle
    A M J McFadden
    Investigation and Diagnostic Centre, Wallaceville, Biosecurity New Zealand, Ministry of Agriculture and Forestry, Upper Hutt 5018, New Zealand
    N Z Vet J 59:79-85. 2011
    ..An outbreak of haemolytic anaemia occurred when 87 cattle were introduced from a presumed non-infected herd from south Otago to a herd in Northland (n=580 cows), New Zealand, where theileriosis is endemic...
  8. ncbi A longitudinal study of disease incidence and case-fatality risks on small-holder dairy farms in coastal Kenya
    S H Maloo
    Kenya Agricultural Research Institute, P.O. Box 10275, Bamburi (Mombasa, Kenya
    Prev Vet Med 52:17-29. 2001
    ..Clinical cases occur the whole year round (especially in young stock)--despite apparent tick control, and in both herded-grazing and stall-feeding system...
  9. ncbi Epidemiological analysis of tick-borne diseases in Zambia
    Martin Simuunza
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Vet Parasitol 175:331-42. 2011
    ..A negative association was observed between the number of co-infecting pathogens and the erythrocyte packed cell volume (PCV) of carrier cattle...
  10. ncbi c-Jun NH2-terminal kinase/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria
    Regina Lizundia
    Institut Cochin, Departement de Maladies Infectieuses, Paris, France
    Cancer Res 66:6105-10. 2006
    ..The similarity between Theileria-transformed B cells with human B lymphomas argues that exploiting the reversible nature of Theileria-induced transformation could throw light on the mechanisms underlying human malignancies...
  11. ncbi Molecular and immunological characterisation of Theileria parva stocks which are components of the 'Muguga cocktail' used for vaccination against East Coast fever in cattle
    R Bishop
    International Livestock Research Institute ILRI, P O Box 30709, Nairobi, Kenya
    Vet Parasitol 94:227-37. 2001
    ..parva Muguga and Serengeti-transformed components in the immunising cocktail. The study demonstrates the value of molecular characterisation data for monitoring of live vaccines...
  12. pmc TGF-b2 induction regulates invasiveness of Theileria-transformed leukocytes and disease susceptibility
    Marie Chaussepied
    Institut Cochin, Universite Paris Descartes, Paris, France
    PLoS Pathog 6:e1001197. 2010
    ..We propose that a TGF-b autocrine loop confers an amoeboid-like motility on Theileria-infected leukocytes, which combines with MMP-dependent motility to drive invasiveness and virulence...
  13. pmc CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity
    Niall D MacHugh
    The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, UK
    Eur J Immunol 39:2459-69. 2009
    ..In conclusion, we have demonstrated a profound immunodominance in the CD8(+) T-cell response to T. parva, which we propose is a major determinant of the parasite strain specificity of the response and hence immune protection...
  14. ncbi Acquisition and transmission of Theileria parva by vector tick, Rhipicephalus appendiculatus
    Satoru Konnai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Acta Trop 99:34-41. 2006
    ..appendiculatus ticks in naturally exposed cattle were relatively high, it would be wise in such a case to consider vector control as well as vaccination against ECF as control measures...
  15. ncbi The incidence, calf morbidity and mortality due to Theileria parva infections in smallholder dairy farms in Murang'a District, Kenya
    G K Gitau
    International Livestock Research Institute, Nairobi, Kenya
    Prev Vet Med 39:65-79. 1999
    ..There are great differences in the epidemiology of ECF within a small area and this implies that there is need to carefully consider different ECF control strategies in different AEZ-grazing strata...
  16. ncbi Genotypic diversity of Theileria orientalis detected from cattle grazing in Kumamoto and Okinawa prefectures of Japan
    Naoaki Yokoyama
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido
    J Vet Med Sci 73:305-12. 2011
    ..orientalis exist in Kumamoto and Okinawa prefectures of Japan and that genotype-specific PCR assays are highly applicable for the quarantine of transported cattle and for epidemiological surveys of bovine theileriosis in Japan...
  17. ncbi In vivo comparison of susceptibility between Bos indicus and Bos taurus cattle types to Theileria parva infection
    S G Ndungu
    Kenya Agricultural Research Institute, National Veterinary Research Centre, P O Box 32, Kikuyu, Kenya
    Onderstepoort J Vet Res 72:13-22. 2005
    ..indicus breds and a B. taurus breed are equally susceptible to T. parva infection. However, Zebus born to dams from an ECF endemic area showed a better ability to control the course of disease than cattle from ECF free areas...
  18. ncbi Failure of the Amblyomma cajennense nymph to become infected by Theileria equi after feeding on acute or chronically infected horses
    Múcio F B Ribeiro
    Departamento de Parasitologia, ICB UFMG, Belo Horizonte, Av Antonio Carlos, 6627 Belo Horizonte, Minas Gerais, Brazil
    Exp Parasitol 128:324-7. 2011
    ..Histopathological analysis failed to detect sporoblast and sporozoites of T. equi in salivary gland acini. This study was not able to observe infection of the A. cajennense by T. equi...
  19. ncbi Enforcing host cell polarity: an apicomplexan parasite strategy towards dissemination
    Martin Baumgartner
    University of Bern, Vetsuisse Faculty, Molecular Pathobiology, Langgassstrasse 122, CH 3012 Bern, Switzerland
    Curr Opin Microbiol 14:436-44. 2011
    ..This parasite strategy highlights mechanisms of motility regulation that are also likely relevant for immune or cancer cell motility...
  20. ncbi The persistence of Theileria parva infection in cattle immunized using two stocks which differ in their ability to induce a carrier state: analysis using a novel blood spot PCR assay
    R A Skilton
    International Livestock Research Institute, Nairobi, Kenya
    Parasitology 124:265-76. 2002
    ..The data suggest that the nature and persistence of the carrier state may differ markedly between different T. parva parasite stocks...
  21. pmc Comparative genomic analysis and phylogenetic position of Theileria equi
    Lowell S Kappmeyer
    Animal Disease Research Unit, Agricultural Research Service, USDA, Pullman, WA 99164 7030, USA
    BMC Genomics 13:603. 2012
    ..equi relative to sequenced apicomplexan parasites...
  22. ncbi Sequence variation identified in the 18S rRNA gene of Theileria mutans and Theileria velifera from the African buffalo (Syncerus caffer)
    Mamohale E Chaisi
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa
    Vet Parasitol 191:132-7. 2013
    ..velifera, with the greatest diversity observed amongst the T. mutans variants. This variation possibly explained why the RLB hybridization assay failed to detect T. mutans and T. velifera in some of the analysed samples...
  23. ncbi Maasai perception of the impact and incidence of malignant catarrhal fever (MCF) in southern Kenya
    Claire Bedelian
    International Livestock Research Institute, Nairobi, Kenya
    Prev Vet Med 78:296-316. 2007
    ..As suggested by pastoralists in this study, the development of compensation schemes or incentives from wildlife would reduce the conflict between livestock keeping and wildlife conservation...
  24. pmc Genotypic diversity, a survival strategy for the apicomplexan parasite Theileria parva
    F Katzer
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    Vet Parasitol 167:236-43. 2010
    ..These markers have also been used to show that passage of mixed parasites through an immunised calf results in the removal of the immunising genotype from the parasite population produced by ticks fed on this animal...
  25. ncbi Identification, genetic diversity and prevalence of Theileria and Babesia species in a sheep population from Northern Spain
    Daniel Nagore
    Department of Animal Health, Instituto Vasco de Investigación y Desarrollo Agrario Berreaga 1, 48160 Derio, Bizkaia, Spain
    Int J Parasitol 34:1059-67. 2004
    ..The widespread distribution of Theileria spp. in the studied sheep population suggests that the parasites involved are of relatively low pathogenicity, in contrast to what has been reported for Theileria sp. China 1 in other countries...
  26. ncbi Prevalence and incidence of tick-borne diseases in smallholder farming systems in the western-Kenya highlands
    O S Okuthe
    National Veterinary Research Centre, Kenya Agricultural Research Institute NVRC KARI, PO Box 32, Kikuyu, Kenya
    Vet Parasitol 141:307-12. 2006
    ..05). The difference in disease frequencies in two areas in close proximity shows the importance of monitoring disease events in order to understand and advice farmers in different production and farming systems appropriately...
  27. ncbi Bovine piroplasms in Minorca (Balearic Islands, Spain): a comparison of PCR-based and light microscopy detection
    S Almeria
    Parasitology, Faculty Veterinary Medicine, Autonomous University of Barcelona, Barcelona, Spain
    Vet Parasitol 99:249-59. 2001
    ..is common and endemic in the island of Minorca and that PCR is the optimal approach for the detection and discrimination of these important parasites...
  28. ncbi Live immunization against East Coast fever--current status
    Giuseppe Di Giulio
    VetAgro Tanzania Ltd, PO Box 13188, Arusha, Tanzania
    Trends Parasitol 25:85-92. 2009
    ..This article outlines the current status of ITM immunization in the field, with associated developments in the molecular epidemiology of T. parva...
  29. ncbi Progress towards understanding the immunobiology of Theileria parasites
    W Ivan Morrison
    The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, UK
    Parasitology 136:1415-26. 2009
    ..This paper summarizes important advances in knowledge of the immunobiology of these parasites over the last 40 years, focusing particularly on areas of relevance to vaccination...
  30. ncbi Ixodes hexagonus is the main candidate as vector of Theileria annae in northwest Spain
    A T Camacho
    Laboratorio Lema and Bandin, C Lepanto, 5 Bajo, 36201 Vigo, Spain
    Vet Parasitol 112:157-63. 2003
    ..In the absence of definitive confirmation of this hypothesis, our observations suggest that I. hexagonus might serve the same role as does Ixodes scapularis (=Ixodes dammini), the vector of B. microti in eastern North America...
  31. ncbi Molecular detection of Theileria and Babesia infections in cattle
    Kursat Altay
    Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119 Elazig, Turkey
    Vet Parasitol 158:295-301. 2008
    ..bigemina was found in three samples (0.77%), B. major in two samples (0.51%) and Babesia sp. in five samples (1.28%). A single animal infected with T. buffeli/orientalis was also infected with B. bigemina...
  32. ncbi Theileriosis in a Missouri beef herd caused by Theileria buffeli: case report, herd investigation, ultrastructure, phylogenetic analysis, and experimental transmission
    S L Stockham
    Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA
    Vet Pathol 37:11-21. 2000
    ..buffeli antigen for an indirect immunofluorescence antibody test. Theilerial isolates from a Missouri white-tailed deer were also sequenced and resembled Theileria sp. types F and G and were not consistent with the bovine organism...
  33. ncbi Infection of calves with Theileria annulata in Tunisia: Economic analysis and evaluation of the potential benefit of vaccination
    Mohamed Gharbi
    Laboratoire de Parasitologie, Ecole Nationale de Medecine Veterinaire, 2020 Sidi Thabet, Tunisia
    Vet Parasitol 137:231-41. 2006
    ..Considering that the vaccine would cost 5 TD (Euro 3.10), the cost-benefit ratio of vaccination is 23.7. Sensitivity analysis of the vaccination costs shows that the indifference decision point is around 118 TD (Euro 73.29)...
  34. ncbi Theileria-induced leukocyte transformation
    Dirk A E Dobbelaere
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, Langgassstrasse 122, CH 3012 Bern, Switzerland
    Curr Opin Microbiol 6:377-82. 2003
    ..The PtdIns-3K/Akt/PKB pathway is also constitutively activated in a parasite-dependent manner, but contrary to IKK, activation is probably not triggered by direct association with the parasite...
  35. ncbi A PKA survival pathway inhibited by DPT-PKI, a new specific cell permeable PKA inhibitor, is induced by T. annulata in parasitized B-lymphocytes
    Julien Guergnon
    Unité de Chimie Organique Equipe Phosphatase et Laboratoire de signalisation Immunoparasitaire, URA CNRS 2581, 75015 Paris, France
    Apoptosis 11:1263-73. 2006
    ..annulata-infected B cells from apoptosis. These results also indicate that DPT-PKI could be a powerful tool to inhibit PKA pathways in other cell types...
  36. ncbi Hemoprotozoa of domestic animals in France: prevalence and molecular characterization
    A Criado-Fornelio
    Parasitology Laboratory, Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Alcala, 28871 Alcala de Henares, Spain
    Vet Parasitol 159:73-6. 2009
    ..in 2 sheep, Theileria buffeli in 5 cows and B. major in 1 cow. Evidence presented in this contribution indicates that haematic protozoa are not widely distributed in domestic mammal populations of France...
  37. ncbi Epidemiological survey of Theileria orientalis infection in grazing cattle in the eastern part of Hokkaido, Japan
    Naomi Ota
    Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    J Vet Med Sci 71:937-44. 2009
    ..The present survey indicated that there were at least five types of T. orientalis classified by their MPSP genes in Hokkaido, Japan, and that T. orientalis infection rates are still high in this region...
  38. ncbi Bos taurus and Bos indicus (Sahiwal) calves respond differently to infection with Theileria annulata and produce markedly different levels of acute phase proteins
    Elizabeth J Glass
    Department of Genetics and Genomics, Roslin Institute, Roslin, Midlothian EH25 9PS, UK
    Int J Parasitol 35:337-47. 2005
    ..In contrast, Sahiwals appear able to overcome infection with T. annulata as well as limit pathology by preventing the over-stimulation of pathways involving these cytokines...
  39. ncbi Immunization against diseases caused by Theileria parva: a review
    G Uilenberg
    A Surgente, Cargèse, Corsica, France
    Trop Med Int Health 4:A12-20. 1999
    ....
  40. ncbi Quantitative analysis of pro-inflammatory cytokine mRNA expression in Theileria annulata-infected cell lines derived from resistant and susceptible cattle
    Kirsty McGuire
    Department of Genomics and Bioinformatics, Roslin Institute, Roslin, Midlothian, Edinburgh EH25 9PS, UK kirsty mcguirebbsrc ac uk
    Vet Immunol Immunopathol 99:87-98. 2004
    ..annulata infection. Other, currently unknown mechanisms may be of greater importance...
  41. ncbi Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)
    R A Skilton
    International Livestock Research Institute ILRI, Nairobi, Kenya
    Parasitology 117:321-30. 1998
    ..Immunoblotting showed that p150 is also expressed by the schizont stage, but at much lower levels compared to the sporozoite. These results suggest a major role for p150 in the early events of host-sporozoite interaction...
  42. ncbi Linkage disequilibrium between alleles at highly polymorphic mini- and micro-satellite loci of Theileria parva isolated from cattle in three regions of Kenya
    D O Odongo
    International Livestock Research Institute, P O Box 30709, Nairobi 00100, Kenya
    Int J Parasitol 36:937-46. 2006
    ..parva populations. A novel observation was that disequilibrium was also detected between alleles at three individual pairs of VNTR loci when isolates from the three regional meta-populations were pooled for analysis...
  43. ncbi Evaluation of cytochrome b as a sensitive target for PCR based detection of T. annulata carrier animals
    Huseyin B Bilgic
    Faculty of Veterinary Medicine, Department of Parasitology, Adnan Menderes University, Işikli Mevki, 09016 Aydin, Turkey huseyin
    Vet Parasitol 174:341-7. 2010
    ..The use of this assay will increase the accuracy of epidemiological studies aimed at improving disease control in endemically unstable regions...
  44. ncbi Differences in the transcriptional responses induced by Theileria annulata infection in bovine monocytes derived from resistant and susceptible cattle breeds
    Kirsty Jensen
    Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian, Edinburgh EH25 9PS, UK
    Int J Parasitol 38:313-25. 2008
    ..annulata infection...
  45. ncbi Theileria orientalis MPSP types in Australian cattle herds associated with outbreaks of clinical disease and their association with clinical pathology findings
    Graeme J Eamens
    NSW Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Camden, New South Wales 2568, Australia
    Vet Parasitol 191:209-17. 2013
    ..In New South Wales, 11 of 14 regulatory districts yielded Ikeda positive samples, with five (Mid-Coast, Cumberland, Central North, Hume and Lachlan) containing 234/307 (76%) of the Ikeda positive samples...
  46. ncbi Living with the enemy or uninvited guests: functional genomics approaches to investigating host resistance or tolerance traits to a protozoan parasite, Theileria annulata, in cattle
    Elizabeth J Glass
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    Vet Immunol Immunopathol 148:178-89. 2012
    ..Next generation sequencing and RNAi methodologies for livestock species will bring new opportunities to link diversity at the genome level to functional differences in health traits in livestock species...
  47. ncbi Molecular diagnosis of theileriosis and heartwater in bovines in Africa
    Nicola E Collins
    Onderstepoort Veterinary Institute, Private Bag X5, Ondesterpoort 0110, South Africa
    Trans R Soc Trop Med Hyg 96:S217-24. 2002
    ..Routine application of these tests has led to the discovery of new genotypes that are probably not E. ruminantium but are probably new species of Ehrlichia...
  48. pmc Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva
    P Toye
    International Laboratory for Research on Animal Diseases, Nairobi, Kenya
    Infect Immun 64:1832-8. 1996
    ..The latter sera did not, however, neutralize sporozoite infectivity in vitro. These results will be useful in exploiting the strain identification, diagnostic, and immunizing potentials of this family of antigens...
  49. pmc Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency
    Robert H Mealey
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    Clin Vaccine Immunol 19:100-4. 2012
    ..equi merozoite stabilate, delayed time to peak parasitemia occurred. Protective effects were associated with a predominance of passively transferred merozoite-specific IgG3...
  50. ncbi Molecular epidemiological survey of Theileria orientalis in Thua Thien Hue Province, Vietnam
    Altangerel Khukhuu
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    J Vet Med Sci 73:701-5. 2011
    ..6%), 1 sheep (4.8%) and 9 ticks (10.6%). Phylogenetic analysis using MPSP gene sequences showed the presence of seven genotypes, four previously categorized genotypes (Types 1, 3, 5 and 7) and three new genotypes (Types N-1, N-2 and N-3)...
  51. ncbi Cytoplasmic sequestration of p53 promotes survival in leukocytes transformed by Theileria
    D Haller
    Division of Veterinary Infection Biology and Immunology, Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    Oncogene 29:3079-86. 2010
    ....
  52. ncbi Detection of Theileria and Babesia in brown brocket deer (Mazama gouazoubira) and marsh deer (Blastocerus dichotomus) in the State of Minas Gerais, Brazil
    Júlia A G da Silveira
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Vet Parasitol 177:61-6. 2011
    ..14.3%), Babesia bovis (4.8%) and Babesia bigemina (4.8%). However, only one of the infected wild cervids exhibited accentuated anaemia (PCV=17%). This is first report concerning the occurrence of Theileria spp. in Brazilian cervids...
  53. ncbi Identification of Theileria parva and Theileria sp. (buffalo) 18S rRNA gene sequence variants in the African Buffalo (Syncerus caffer) in southern Africa
    Mamohale E Chaisi
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa
    Vet Parasitol 182:150-62. 2011
    ..parva variants and, although amplicons were obtained from Theileria sp. (buffalo) DNA, none of the Theileria sp. (buffalo) 18S rRNA sequence variants were detected by the T. parva-specific hybridization probes...
  54. ncbi Molecular prevalence of different genotypes of Theileria orientalis detected from cattle and water buffaloes in Thailand
    Khukhuu Altangerel
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    J Parasitol 97:1075-9. 2011
    ..orientalis in Thailand. In conclusion, T. orientalis parasites circulating in Thailand are more diverse in their genetic characters than previously anticipated...
  55. ncbi A panel of microsatellite and minisatellite markers for the characterisation of field isolates of Theileria parva
    C A L Oura
    Department of Microbiology and Parasitology, Veterinary Faculty, University of Makerere, P O Box 7062, Kampala, Uganda
    Int J Parasitol 33:1641-53. 2003
    ..parva. Cluster analysis of multilocus genotypes from the 14 isolates (using a neighbour joining algorithm) revealed that genetic similarity between isolates was not obviously related to their geographical origin...
  56. ncbi Diagnostic real-time PCR assay for the quantitative detection of Theileria equi from equine blood samples
    Chul Min Kim
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 151:158-63. 2008
    ..equi in the remaining 19 negative blood samples. This quantitative real-time PCR assay provides a valuable tool for fast laboratory diagnostic assessment of T. equi infection in horses...
  57. ncbi Study of Theileria annulata population structure during bovine infection and following transmission to ticks
    M J Gubbels
    Department of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Parasitology 123:553-61. 2001
    ..Although only a limited number of ticks were studied, these preliminary data suggest that specific parasite genotypes may be selected during tick transmission from a carrier animal...
  58. ncbi Financial analysis of East Coast fever control strategies in traditionally managed Sanga cattle in Central Province of Zambia
    B Minjauw
    ILRI Kenya, Nairobi, Kenya
    Prev Vet Med 38:35-45. 1999
    ..For herds under intensive tick control, immunisation was of no financial benefit. The results demonstrate the value of immunisation, and indicate the importance of its combination with seasonal tick-control measures...
  59. ncbi Epidemiology of Mediterranean theileriosis in Extremadura region, Spain
    M Habela
    Department of Parasitology and Parasitic Diseases, School of Veterinary Medicine, University of Extremadura, Caceres, Spain
    Parassitologia 41:47-51. 1999
    ..The disease is unstable in semi-extensive systems (dairy cows) and tends to stabilisation on extensive farms for meat and fighting bulls...
  60. ncbi Organisation and informational content of the Theileria parva genome
    V Nene
    International Livestock Research Institute, Nairobi, Kenya
    Mol Biochem Parasitol 95:1-8. 1998
    ..The parasite mitochondrial DNA is linear in structure, has a limited protein coding capacity and fragmented rRNA genes and its telomeres contain inverted repeat sequences...
  61. ncbi Nested polymerase chain reaction for detection of Theileria annulata and comparison with conventional diagnostic techniques: its use in epidemiology studies
    J Martin-Sanchez
    Departamento de Produccion Animal, CIFA, Granada, Spain
    Parasitol Res 85:243-5. 1999
    ..3%) and that obtained using all three diagnostic techniques together (80.4%) did not significantly differ verifies the utility of this technique in epidemiology studies...
  62. ncbi Development and evaluation of a real-time polymerase chain reaction test for the detection of Theileria parva infections in Cape buffalo (Syncerus caffer) and cattle
    Kgomotso P Sibeko
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    Vet Parasitol 155:37-48. 2008
    ..parva diagnostics and can reliably detect the parasite in carrier animals with a piroplasm parasitaemia as low as 8.79 x 10(-4)%...
  63. ncbi Assessing the impact of East Coast Fever immunisation by the infection and treatment method in Tanzanian pastoralist systems
    S Babo Martins
    The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Prev Vet Med 97:175-82. 2010
    ..Furthermore, the economic analysis showed that ITM generated a profit estimated to be 7250 TZS (1 USD=1300 TZS) per vaccinated calf, and demonstrated that it was a better control measure than natural infection and subsequent treatment...
  64. ncbi Detection of Theileria annulata in cattle and vector ticks by PCR using the Tams1 gene sequences
    E Kirvar
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Midlothian, UK
    Parasitology 120:245-54. 2000
    ..annulata to the same sensitivity and specificity in saponin-extracted DNA samples stored for long periods at -20 degrees C...
  65. ncbi Escape from CD8+ T cell response by natural variants of an immunodominant epitope from Theileria parva is predominantly due to loss of TCR recognition
    Timothy K Connelley
    The Roslin Institute and The Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, Scotland, United Kingdom
    J Immunol 187:5910-20. 2011
    ..The levels of heterozygosity in individual Tp2(49-59) residues correlated closely with loss of immune recognition, suggesting that immune selection has contributed to epitope polymorphism...
  66. ncbi Equine babesiosis: seroprevalence, risk factors and comparison of different diagnostic methods in Jordan
    S M Abutarbush
    Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan
    Transbound Emerg Dis 59:72-8. 2012
    ..Competitive enzyme-linked immunosorbent assay (cELISA) test appears to be more reliable than microscopic examination and PCR in estimating the seroprevalence of the disease as well as identifying carrier horses to babesiosis...
  67. ncbi Mediterranean theileriosis and other tick transmitted piroplasmoses in cattle in Minorca (Balearic Islands, Spain): the effect of tick control on prevalence levels analyzed by reverse line blot (RLB) macroarrays
    Sonia Almeria
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA and Departament de Sanitat i Anatomia Animals, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Parasitol 95:598-603. 2009
    ..Adequate control measures and vaccination approaches are required to improve the situation of Mediterranean theileriosis on the island...
  68. ncbi [Prevalence of tropical theileriosis in cattle in the Aydin Region and determination of efficacy of attenuated Theileria annulata vaccine]
    Nuran Aysul
    Adnan Menderes Universitesi Veteriner Fakultesi, Parazitoloji Anabilim Dali, Aydin, Turkey
    Turkiye Parazitol Derg 32:322-7. 2008
    ..Results indicated that the incidence of the disease varied among the regions. Clinical theileriosis was found in a total of 22 cattle (10 vaccinated, 12 unvaccinated) during the disease season...
  69. ncbi Prevalence and distribution of tropical theileriosis in eastern Turkey
    N Dumanli
    Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119 Elazig, Turkey
    Vet Parasitol 127:9-15. 2005
    ..A total of 179 ticks (136 female; 43 male) belonging to Hyalomma spp. were collected from cattle from three towns. Ticks were identified to be Hyalomma anatolicum anatolicum on the basis of morphological features...
  70. pmc Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
    Roger Pelle
    International Livestock Research Institute, Nairobi, Kenya
    PLoS ONE 6:e19015. 2011
    ..This study set out to determine the nature and extent of polymorphism in two of these antigens, Tp1 and Tp2, which contain defined CD8(+) T-cell epitopes, and to analyse the sequences for evidence of selection...
  71. ncbi Molecular phylogenetic studies on Theileria parasites based on small subunit ribosomal RNA gene sequences
    K Chansiri
    Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand
    Vet Parasitol 83:99-105. 1999
    ..However, more basic information such as life cycle differences, vectors, modes of transmission, virulent and genetic/sexual compatability is essential for clearer taxonomic definition of the benign Theileria parasites...
  72. ncbi An outbreak of East Coast Fever on the Comoros: a consequence of the import of immunised cattle from Tanzania?
    R De Deken
    Institute of Tropical Medicine Antwerp, Nationalestraat 155, B 2000 Antwerp, Belgium
    Vet Parasitol 143:245-53. 2007
    ....
  73. ncbi Cattle infestation by Hyalomma ticks and prevalence of Theileria in Hyalomma species in the east of Turkey
    M Aktas
    Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119 Elazig, Turkey
    Vet Parasitol 119:1-8. 2004
    ..detritum, respectively. In H.a. anatolicum collected from shelters, the above rates were 11.8 and 17.6 in male and female ticks, respectively. The prevalence and intensity of Theileria infection was greater in female ticks than in males...
  74. ncbi Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
    Lavoisier Akoolo
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 121:216-21. 2008
    ..Immunoscreening of the T. parva genome with these CTL lines should identify novel antigens that will constitute valuable additions to the vaccine candidates currently being evaluated...
  75. ncbi Impact of field vaccination with a Theileria annulata schizont cell culture vaccine on the epidemiology of tropical theileriosis
    S Singh
    Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary Sciences, Chaudhary Charan Singh Haryana Agricultural University, Hisar 125004, India
    Vet Parasitol 101:91-100. 2001
    ..Clinical cases of theileriosis were recorded only in the non-vaccinated group suggesting that vaccinated animals were sufficiently immune to withstand field tick challenge for at least 14 months...
  76. ncbi A molecular phylogeny of the benign Theileria parasites based on major piroplasm surface protein (MPSP) gene sequences
    W Jeong
    Division of Veterinary Biotechnology, National Veterinary Research and Quarantine Service, 480, Anyang 6 dong, Anyang, Gyeonggido, 430 824 South Korea
    Parasitology 137:241-9. 2010
    ..Our sequence data showed no geographical influence on worldwide Theileria parasite distribution...
  77. ncbi A molecular survey of bovine Theileria parasites among apparently healthy cattle and with a note on the distribution of ticks in eastern Turkey
    Munir Aktas
    Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119 Elazig, Turkey
    Vet Parasitol 138:179-85. 2006
    ..R. sanguineus was the minor species and represented 8% (59/724) of the tick population...
  78. ncbi Transformation of leukocytes by Theileria parva and T. annulata
    D Dobbelaere
    Department of Molecular Pathology, University of Berne, Switzerland
    Annu Rev Microbiol 53:1-42. 1999
    ..This, in turn, leads to the activation of transcription factors, including nuclear factor-kappa B, which appear to be essential for the survival of Theileria-transformed T cells...
  79. ncbi Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes
    Brian Shiels
    Division of Veterinary Infection and Immunity, Parasitology Group, Institute of Comparative Medicine, Faculty of Veterinary Medicine, Bearsden Rd, Glasgow G61 1QH, UK
    Int J Parasitol 36:9-21. 2006
    ..This review summarizes current knowledge of the mechanisms used by Theileria parasites to transform the host cell, and highlights recent work that has mined the Theileria genomes to identify candidate manipulators of host cell phenotype...
  80. ncbi Incidence and prevalence of tick-borne haemoparasites in domestic ruminants in Ghana
    L Bell-Sakyi
    Accra Veterinary Laboratory, Veterinary Services Department, Ministry of Food and Agriculture, PO Box M161, Accra, Ghana
    Vet Parasitol 124:25-42. 2004
    ....
  81. ncbi Population genetic analysis and sub-structuring of Theileria parva in Uganda
    C A L Oura
    Department of Microbiology and Parasitology, Faculty of Vet Medecine, University of Makerere, P O Box 7062, Kampala, Uganda
    Mol Biochem Parasitol 140:229-39. 2005
    ..The population from Kayunga was in linkage disequilibrium. Genetic distances and Wrights fixation index (F(ST)) indicate that there is evidence for geographical sub-structuring between the Lira and the Kayunga populations...
  82. ncbi Repeated high dose imidocarb dipropionate treatment did not eliminate Babesia caballi from naturally infected horses as determined by PCR-reverse line blot hybridization
    C M Butler
    Department of Equine Sciences, Medicine Section, Utrecht University, PO Box 80 153, 3508 TD Utrecht, The Netherlands
    Vet Parasitol 151:320-2. 2008
    ..These results confirm that the CFT is not a suitable test for pre-import testing and that even high dose treatment with imidocarb may not be capable of eliminating B. caballi and T. equi infections from healthy carriers...
  83. ncbi Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres
    R Bishop
    International Livestock Research Institute ILRI, Nairobi, Kenya
    Mol Biochem Parasitol 110:359-71. 2000
    ..T. parva is unusual, among organisms so far studied, in the high density of potential coding sequences located directly adjacent to telomeres and the apparent absence of extensive tracts of repeated sequences within the TA DNA...
  84. ncbi Development and evaluation of real-time PCR assays for the quantitative detection of Babesia caballi and Theileria equi infections in horses from South Africa
    Raksha Bhoora
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, South Africa
    Vet Parasitol 168:201-11. 2010
    ..equi-specific qPCR assay could positively detect T. equi DNA in 80% of the samples. These results suggest that the qPCR assays are more sensitive than the RLB assay for the detection of T. equi and B. caballi infections in field samples...
  85. ncbi Bovine immunity - a driver for diversity in Theileria parasites?
    Declan J McKeever
    Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
    Trends Parasitol 25:269-76. 2009
    ..This review considers whether bovine immunity acts as a driver for diversity in T. parva and T. annulata and explores other factors that might underlie genetic variation in these parasites...
  86. ncbi Proinflammatory cytokine expression by Theileria annulata infected cell lines correlates with the pathology they cause in vivo
    S P Graham
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin EH25 9RG, UK
    Vaccine 19:2932-44. 2001
    ....
  87. ncbi Identification of a piroplasm protein of Theileria orientalis that binds to bovine erythrocyte band 3
    Jung Yeon Kim
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Mol Biochem Parasitol 137:193-200. 2004
    ....
  88. pmc Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
    Simon P Graham
    International Livestock Research Institute, Nairobi, Kenya
    Proc Natl Acad Sci U S A 103:3286-91. 2006
    ..These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites...
  89. ncbi Haemolytic anaemia in cattle in NSW associated with Theileria infections
    M M Izzo
    Livestock Veterinary Teaching and Research Unit, University of Sydney, 410 Werombi Rd, Camden, New South Wales 2570, Australia
    Aust Vet J 88:45-51. 2010
    ..Treatments included both registered and non-registered products. There is a possibility of a new strain of Theileria sp. in Australia and the possible vectors encountered in NSW are discussed...
  90. ncbi Theileria buffeli infection of a Michigan cow confirmed by small subunit ribosomal RNA gene analysis
    Raquel Cossio-Bayugar
    Department of Veterinary Pathobiology, The Texas Veterinary Medical Center, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Parasitol 105:105-10. 2002
    ..buffeli. The parasite was confirmed to be T. buffeli by SSU rRNA gene sequence analysis (SSU rRNA sequence, Type A). This represents the first report of this parasite in an animal in Michigan...
  91. ncbi Studies on the epidemiology of tropical theileriosis (Theileria annulata infection) in cattle in Central Anatolia, Turkey
    F Sayin
    Department of Protozoology and Medical Entomology, Faculty of Veterinary Medicine, University of Ankara, 06110 Ankara, Turkey
    Trop Anim Health Prod 35:521-39. 2003
    ..The two different management systems encountered in the study were considered to have influenced the tick infestation levels...
  92. ncbi Infectivity and cross-immunity studies of Theileria lestoquardi and Theileria annulata in sheep and cattle: I. In vivo responses
    I Leemans
    Department of Parasitology, Swedish University of Agricultural Sciences and National Veterinary Institute, Uppsala
    Vet Parasitol 82:179-92. 1999
    ..lestoquardi, resulting in the establishment of schizonts and their subsequent development into piroplasms, although it protected against the major clinical effects of T. lestoquardi infection...
  93. ncbi Reduction in tick numbers (Haemaphysalis longicornis), mortality and incidence of Theileria sergenti infection in field-grazed calves treated with flumethrin pour-on
    S Shimizu
    National Institute of Animal Health, 305 0856, Tsukuba, Japan
    Vet Parasitol 92:129-38. 2000
    ..These results indicated that multiple-year seasonal application of flumethrin pour-on to grazing cattle effectively decreased the number of ticks and decreased both mortality and incidence of T. sergenti...
  94. ncbi The biological and practical significance of antigenic variability in protective T cell responses against Theileria parva
    W I Morrison
    Division of Veterinary Clinical Sciences, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK
    Vet Parasitol 148:21-30. 2007
    ....
  95. ncbi Tropical theileriosis: cytotoxic T lymphocyte response to vaccination
    Ulrike Seitzer
    Veterinary Infection Biology and Immunology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Vaccine 26:G24-8. 2008
    ..Any strain-specificity induced by immunisation is likely to be manifested by CTL. Besides CTLs, CD4+ T-cells also play an important role in protective immunity to T. annulata infection...
  96. pmc Influence of host immunity on parasite diversity in Theileria parva
    Frank Katzer
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, United Kingdom
    Infect Immun 75:4909-16. 2007
    ..These observations suggest that immunity does not prevent transmission of challenge parasites and that its impact on the parasite at a population level is influenced by herd MHC diversity...
  97. pmc A rapid and sensitive intracellular flow cytometric assay to identify Theileria parva infection within target cells
    M S Rocchi
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland
    Parasitology 135:195-201. 2008
    ..Analysis of infected cells between 48 and 72 h post-infection clearly defines the potential transforming capability of different stabilates...
  98. ncbi Dissection of the clonal composition of bovine alphabeta T cell responses using T cell receptor Vbeta subfamily-specific PCR and heteroduplex analysis
    T Connelley
    Division of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, UK
    J Immunol Methods 335:28-40. 2008
    ..The development and validation of these methods provides for the first time a generic set of molecular tools that can be used to perform detailed analysis of the TCR diversity and clonal composition of bovine T cell responses...
  99. ncbi Epidemiological studies on Theileriosis and the dynamics of Theileria parva infections in Rwanda
    T Bazarusanga
    National Veterinary Laboratory of Rwanda, BP 804 Kigali, Rwanda
    Vet Parasitol 143:214-21. 2007
    ..Another important finding was the fact that young animals are infected early in life in all regions except in the high land zone indicating the existence of a particular epidemiological situation in this part of the country...
  100. pmc Theileria parva and the bovine CTL response: down but not out?
    D J McKeever
    Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    Parasite Immunol 28:339-45. 2006
    ..This review discusses the issue of how CTL immunity is likely to impact on parasite population structure in the light of available information on diversity of the parasite and its ability to recombine...
  101. ncbi Resistance and susceptibility to a protozoan parasite of cattle--gene expression differences in macrophages from different breeds of cattle
    Elizabeth J Glass
    Department of Genetics and Genomics, Roslin Institute, Roslin, Midlothian EH25 9PS, UK
    Vet Immunol Immunopathol 120:20-30. 2007
    ..annulata. Our results indicate that there are fundamental differences in gene expression in mphi from both breeds in the way they respond to infection, and even in their pre-infection resting state...

Research Grants4

  1. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    ....
  2. EIAV Control by High Avidity Rev-Specific CTL Clones
    ROBERT MEALEY; Fiscal Year: 2005
    ..The information obtained from the proposed studies should have implications for HIV-1 immunotherapy and vaccine design, where experiments of this type may be more difficult. ..
  3. EIAV Control by DNA Vaccine-Induced CTL
    ROBERT MEALEY; Fiscal Year: 2006
    ..The information obtained from the proposed studies should have implications for HIV-1 vaccine design, where experiments of this type may be more difficult. [unreadable] [unreadable]..
  4. GENETIC DISSECTION OF TOXOPLASMA GONDII
    David Roos; Fiscal Year: 2008
    ..In addition to their value for the analysis of folate metabolism and drug resistance, these tools should be broadly applicable to other studies on the biology and biochemistry of Toxoplasma. ..