hidradenitis suppurativa

Summary

Summary: A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident. Hormonal mechanisms are expected in its pathogenesis.

Top Publications

  1. ncbi Superior and inferior gluteal artery perforator flaps in reconstruction of gluteal and perianal/perineal hidradenitis suppurativa lesions
    Cigdem Unal
    Plastic Reconstructive and Aesthetic Surgery Department, Kocaeli University Medical Faculty, Umuttepe, Izmit, Turkey
    Microsurgery 31:539-44. 2011
  2. ncbi Psychosocial impact of hidradenitis suppurativa: a qualitative study
    Solveig Esmann
    Department of Dermatology, Roskilde Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Acta Derm Venereol 91:328-32. 2011
  3. ncbi Hidradenitis suppurativa: successful treatment using carbon dioxide laser excision and marsupialization
    Paul G Hazen
    Department of Dermatology, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Dermatol Surg 36:208-13. 2010
  4. ncbi Hidradenitis suppurativa: a comprehensive review
    Ali Alikhan
    University of California Davis School of Medicine, Sacramento, California 95816, USA
    J Am Acad Dermatol 60:539-61; quiz 562-3. 2009
  5. ncbi Surgical treatment of hidradenitis suppurativa: experiences and recommendations
    Andrzej Bieniek
    Department of Dermatology, Medical University, Wrocław, Poland
    Dermatol Surg 36:1998-2004. 2010
  6. ncbi Treatment of axillary hidradenitis with transposition flaps: a 6-year experience
    George Varkarakis
    Division of Plastic Surgery, University of Mississippi Medical Center, Jackson, MS, USA
    Ann Plast Surg 64:592-4. 2010
  7. ncbi Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, D 10117 Berlin, Germany
    J Immunol 186:1228-39. 2011
  8. ncbi Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β
    H H van der Zee
    Department of Dermatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Br J Dermatol 164:1292-8. 2011
  9. ncbi Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity
    Florence Canoui-Poitrine
    Laboratoire d Investigation Clinique EA4393, Universite Paris 12, Creteil, France
    J Am Acad Dermatol 61:51-7. 2009
  10. ncbi A systematic review of treatments for hidradenitis suppurativa
    Pranita V Rambhatla
    Follicular Disorders Clinic, Department of Dermatology, Henry Ford Hospital, 3031 W Grand Blvd, Detroit, MI 48202, USA
    Arch Dermatol 148:439-46. 2012

Research Grants

Detail Information

Publications235 found, 100 shown here

  1. ncbi Superior and inferior gluteal artery perforator flaps in reconstruction of gluteal and perianal/perineal hidradenitis suppurativa lesions
    Cigdem Unal
    Plastic Reconstructive and Aesthetic Surgery Department, Kocaeli University Medical Faculty, Umuttepe, Izmit, Turkey
    Microsurgery 31:539-44. 2011
    b>Hidradenitis suppurativa is a debilitating disease with a tendency to form abscesses, sinus tracts, and scar formation...
  2. ncbi Psychosocial impact of hidradenitis suppurativa: a qualitative study
    Solveig Esmann
    Department of Dermatology, Roskilde Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Acta Derm Venereol 91:328-32. 2011
    b>Hidradenitis suppurativa influences patients' lives in many ways. It is therefore necessary to focus on the effects of the disease on daily life in order better to define patient-related outcomes in hidradenitis suppurativa studies...
  3. ncbi Hidradenitis suppurativa: successful treatment using carbon dioxide laser excision and marsupialization
    Paul G Hazen
    Department of Dermatology, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Dermatol Surg 36:208-13. 2010
    b>Hidradenitis suppurativa (HS) is a disease associated with significant patient morbidity and less-than-ideal therapies.
  4. ncbi Hidradenitis suppurativa: a comprehensive review
    Ali Alikhan
    University of California Davis School of Medicine, Sacramento, California 95816, USA
    J Am Acad Dermatol 60:539-61; quiz 562-3. 2009
    b>Hidradenitis suppurativa, also known as acne inversa, is a chronic, often debilitating disease primarily affecting the axillae, perineum, and inframammary regions. Prevalence rates of up to 4% have been estimated...
  5. ncbi Surgical treatment of hidradenitis suppurativa: experiences and recommendations
    Andrzej Bieniek
    Department of Dermatology, Medical University, Wrocław, Poland
    Dermatol Surg 36:1998-2004. 2010
    To describe our own surgical techniques of wound closure in pubic and armpit areas in the treatment of hidradenitis suppurativa (HS) and to analyze surgical procedures performed with regard to complications, tolerance, and factors ..
  6. ncbi Treatment of axillary hidradenitis with transposition flaps: a 6-year experience
    George Varkarakis
    Division of Plastic Surgery, University of Mississippi Medical Center, Jackson, MS, USA
    Ann Plast Surg 64:592-4. 2010
    ..Twenty flaps (95%) healed without axillary contracture. One failed flap required skin graft coverage. Transposition flap coverage in these patients was a reliable, single-stage reconstruction allowing prompt arm movement...
  7. ncbi Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, D 10117 Berlin, Germany
    J Immunol 186:1228-39. 2011
    ..As demonstrated in this study, acne inversa (AI; also designated as Hidradenitis suppurativa) lesions show a relative deficiency of IL-22 and IL-20, but not of IL-17A, IL-26, IFN-γ, IL-24, or IL-1β..
  8. ncbi Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β
    H H van der Zee
    Department of Dermatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Br J Dermatol 164:1292-8. 2011
    The pathogenesis of hidradenitis suppurativa (HS) is largely unknown and the disease is difficult to treat. Patients are in high need of an effective treatment...
  9. ncbi Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity
    Florence Canoui-Poitrine
    Laboratoire d Investigation Clinique EA4393, Universite Paris 12, Creteil, France
    J Am Acad Dermatol 61:51-7. 2009
    Factors associated with the severity of hidradenitis suppurativa (HS) are not known.
  10. ncbi A systematic review of treatments for hidradenitis suppurativa
    Pranita V Rambhatla
    Follicular Disorders Clinic, Department of Dermatology, Henry Ford Hospital, 3031 W Grand Blvd, Detroit, MI 48202, USA
    Arch Dermatol 148:439-46. 2012
    To conduct a systematic review of the effectiveness of various modalities to treat hidradenitis suppurativa (HS) and to establish recommendations on its appropriate management.
  11. pmc A prospective clinical trial of open-label etanercept for the treatment of hidradenitis suppurativa
    Robert A Lee
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Acad Dermatol 60:565-73. 2009
    Medical therapies for hidradenitis suppurativa (HS) are often ineffective. Tumor necrosis factor-alpha inhibitors may be a potential treatment for patients with moderate to severe HS.
  12. ncbi Hidradenitis suppurativa and concomitant pyoderma gangrenosum: a case series and literature review
    Jennifer L Hsiao
    Department of Dermatology, University of California at San Francisco, CA, USA
    Arch Dermatol 146:1265-70. 2010
    b>Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are both rare inflammatory skin conditions that are associated with systemic inflammatory diseases...
  13. ncbi The thoracodorsal artery perforator flap in the treatment of axillary hidradenitis suppurativa: effect on preservation of arm abduction
    Fabio F Busnardo
    Division of Plastic Surgery, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Plast Reconstr Surg 128:949-53. 2011
    b>Hidradenitis suppurativa is a chronic, recurrent inflammatory disease of the skin characterized by abscesses and scars. The axillary region is predominantly affected, leading to limited mobility of the arm due to scar retraction...
  14. ncbi Pathogenesis and pharmacotherapy of Hidradenitis suppurativa
    Maiwand Nazary
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, P O Box 80 082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 672:1-8. 2011
    The focus of this review is to discuss the pathogenesis and the pharmacotherapy of Hidradenitis suppurativa (HS)...
  15. ncbi Dapsone therapy for hidradenitis suppurativa: a series of 24 patients
    Shiva Yazdanyar
    Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Roskilde, Denmark
    Dermatology 222:342-6. 2011
    b>Hidradenitis suppurativa (HS) is an inflammatory skin disease with a chronic intermittent course. HS is difficult to treat, and the evidence for the effect of most treatments consists of smaller open studies...
  16. ncbi Hidradenitis suppurativa resulting in systemic amyloid A amyloidosis: a case report and review of the literature
    Sasha D Girouard
    Harvard Medical School, Boston, Massachusetts, USA
    Dermatol Online J 18:2. 2012
    b>Hidradenitis suppurativa is a chronic, inflammatory disease of the follicular epithelium that presents as tender, subcutaneous nodules in an intertriginous distribution with sinus tract formation...
  17. ncbi Surgical treatment of hidradenitis suppurativa with gentamicin sulfate: a prospective randomized study
    Mathijs G Buimer
    Rijnstate Hospital, Arnhem, The Netherlands
    Dermatol Surg 34:224-7. 2008
    ..and discusses a prospective randomized study with gentamicin sulfate in the surgical treatment of hidradenitis suppurativa. The purpose of the study was to investigate whether enclosure of antibiotics after primary excision and ..
  18. ncbi Hidradenitis suppurativa: the role of deficient cutaneous innate immunity
    Brigitte Dreno
    Institut National de la Santéet de la Recherche Médicale INSERM, U892, Centre de Recherche en Cancérologie Nantes Angers, France
    Arch Dermatol 148:182-6. 2012
    To evaluate the expression of innate immunity markers at the site of nodules caused by hidradenitis suppurativa (HS).
  19. ncbi Prospective controlled clinical and histopathologic study of hidradenitis suppurativa treated with the long-pulsed neodymium:yttrium-aluminium-garnet laser
    Bassel H Mahmoud
    Mulitcultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA
    J Am Acad Dermatol 62:637-45. 2010
    b>Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving the intertriginous areas.
  20. ncbi Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial
    Annika Grant
    Florida Academic Dermatology Centers, Miami, Florida 33136, USA
    J Am Acad Dermatol 62:205-17. 2010
    Biologic therapies with anti-tumor necrosis factor agents are promising treatments for hidradenitis suppurativa (HS).
  21. ncbi Hidradenitis suppurativa: a review of cause and treatment
    Shiva Yazdanyar
    Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Infect Dis 24:118-23. 2011
    b>Hidradenitis suppurativa is a chronic or relapsing inflammatory cutaneous disorder manifested by recurrent formation of abscesses, fistulating sinus and scarring in the apocrine-gland-bearing skin...
  22. ncbi Thoracodorsal artery perforator (TAP) type I V-Y advancement flap in axillary hidradenitis suppurativa
    Nabiha Rehman
    Castle Hill Hospital, Hull HU16 5JQ, UK
    Br J Plast Surg 58:441-4. 2005
    b>Hidradenitis suppurativa is a chronic debilitating disease. Surgical removal of all apocrine glands in the affected region is the definitive treatment. The resulting wound may either be left to heal secondarily or closed primarily...
  23. ncbi What causes hidradenitis suppurativa?
    H Kurzen
    Exp Dermatol 17:455-6; discussion 457-72. 2008
    b>Hidradenitis suppurativa (HS)--a rather common, very chronic and debilitating inflammatory skin appendage disorder with a notoriously underestimated burden of disease--has long been a playground for the high priests of nomenclature: Ask a ..
  24. ncbi Hidradenitis suppurativa/acne inversa: bilocated epithelial hyperplasia with very different sequelae
    M von Laffert
    Department of Dermatology and Venereology, Martin Luther University Halle Wittenberg, Ernst Kromayer Strasse 5, D 06097 Halle Saale, Germany
    Br J Dermatol 164:367-71. 2011
    b>Hidradenitis suppurativa/acne inversa is a chronic, inflammatory, scarring disease in the terminal hair follicle and apocrine gland-bearing areas (skin folds)...
  25. ncbi Hidradenitis suppurativa of the groin treated by radical excision and defect closure by medial thigh lift: aesthetic surgery meets reconstructive surgery
    Ulrich M Rieger
    Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    J Plast Reconstr Aesthet Surg 62:1355-60. 2009
    b>Hidradenitis suppurativa of the groin is a chronic, relapsing inflammatory disease of the skin and subcutaneous tissues. Radical surgical excision is the treatment of choice...
  26. ncbi Hidradenitis suppurativa in 64 female patients: retrospective study comparing oral antibiotics and antiandrogen therapy
    John N Kraft
    Division of Dermatology, University of Toronto, Toronto, ON, Canada
    J Cutan Med Surg 11:125-31. 2007
    b>Hidradenitis suppurativa (HS) is a recurrent disease confined to apocrine gland-bearing areas causing painful, deep-seated lesions and draining sinus tracts. Uniformly effective therapy is lacking...
  27. pmc Surgical management of hidradenitis suppurativa
    Adnan Menderes
    Plastic Rec and Aesthetic Surgery, Medical Faculty, Dokuz Eylul University, Inciralti Izmir, Turkey
    Int J Med Sci 7:240-7. 2010
    b>Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory disease of skin, characterized by recurrent draining sinuses and abscesses, predominantly in skin folds carrying terminal hairs and apocrine glands.
  28. ncbi Long-term successful adalimumab therapy in severe hidradenitis suppurativa
    Ricardo Blanco
    Servicio de Reumatologia, Hospital Universitario Marques de Valdecilla, Avda Valdecilla s n, ES 39008, Santander, Spain
    Arch Dermatol 145:580-4. 2009
    Several studies report the use of tumor necrosis factor alpha (TNF-alpha) inhibitors in refractory hidradenitis suppurativa (HS), particularly infliximab and etanercept...
  29. ncbi Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity
    K Sartorius
    Section of Dermatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Br J Dermatol 161:831-9. 2009
    b>Hidradenitis suppurativa (HS) is a long-standing disease with abscess and often fistula formation, predominantly in the axillae and groins. The disease is difficult to treat and has a severe impact on quality of life...
  30. ncbi Psychophysical aspects of hidradenitis suppurativa
    Lukasz Matusiak
    Department of Dermatology, Venereology and Allergology, Medical University, 50 368 Wroclaw, Poland
    Acta Derm Venereol 90:264-8. 2010
    b>Hidradenitis suppurativa is a recurrent, debilitating suppurative skin disease. The symptoms are much more than just physical, but studies of its impact on patients' psychological state and related quality of life are very limited...
  31. ncbi Surgical approach to extensive hidradenitis suppurativa in the perineal/perianal and gluteal regions
    Emre Balik
    Department of General Surgery, University of Istanbul, Istanbul Faculty of Medicine, Istanbul, Turkey
    World J Surg 33:481-7. 2009
    Verneuil's disease, or hidradenitis suppurativa, is a chronic suppurative disease with a tendency to sinus formation, fibrosis, and sclerosis...
  32. ncbi Gluteal and perianal hidradenitis suppurativa: surgical treatment by wide excision
    Sylvio F Bocchini
    Division of Colorectal Surgery, University of Sao Paulo, Brazil
    Dis Colon Rectum 46:944-9. 2003
    b>Hidradenitis suppurativa is a chronic inflammatory disease of the skin and subcutaneous tissue. Extensive gluteal and perianal disease represents a challenge presentation...
  33. ncbi Painful hidradenitis suppurativa
    Howard S Smith
    Department of Anesthesiology, Academic Director of Pain Management, Albany Medical College, Albany, NY 12208, USA
    Clin J Pain 26:435-44. 2010
    b>Hidradenitis suppurativa (HS) is a chronically relapsing skin disorder characterized by recurring inflammatory lesion in hair and apocrine gland-bearing skin creases in the axilla; groin or perineum, buttocks, and/or breast...
  34. ncbi Current understanding and management of hidradenitis suppurativa
    Amanda C Krbec
    United States Air Force Academy, Colorado Springs, Colorado 80840, USA
    J Am Acad Nurse Pract 19:228-34. 2007
    To review the diagnosis and treatment of hidradenitis suppurativa (HS) in primary care.
  35. ncbi Islanded perforator flaps in the reconstruction of hidradenitis suppurativa defects
    Onur Egemen
    Okmeydani Education and Research Hospital, Plastic and Reconstructive Surgery Clinic, Istanbul, Turkey
    J Reconstr Microsurg 29:297-302. 2013
    b>Hidradenitis suppurativa is a recurrent, chronic, and suppurative cutaneous disease of unknown etiology...
  36. ncbi Questionnaire-based diagnosis of hidradenitis suppurativa: specificity, sensitivity and positive predictive value of specific diagnostic questions
    S Esmann
    Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, DK 4000 Roskilde, Denmark
    Br J Dermatol 163:102-6. 2010
    Estimates of the prevalence of hidradenitis suppurativa (HS) range from 0.33% to 4%. Further epidemiological data are therefore needed...
  37. ncbi Vulvar lymphangioma circumscriptum: a report of 3 cases, 2 associated with vulvar carcinoma and 1 with hidradenitis suppurativa
    Shireen Madani Sims
    Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Low Genit Tract Dis 14:234-7. 2010
    ..Treatment options include observation, surgical excision, laser ablation, or sclerosing therapy. We report 3 cases, 2 associated with vulvar squamous cell carcinoma and 1 with hidradenitis suppurativa.
  38. ncbi Combination therapy with clindamycin and rifampicin for hidradenitis suppurativa: a series of 116 consecutive patients
    G Gener
    Service de Dermatologie, Groupe Henri Mondor Albert Chenevier, AP HP, Creteil, France
    Dermatology 219:148-54. 2009
    Antibiotics are frequently used to treat hidradenitis suppurativa (HS); however, few data on their efficacy are available.
  39. ncbi What causes acne inversa (or hidradenitis suppurativa)?--the debate continues
    Klaus Sellheyer
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Cutan Pathol 35:701-3. 2008
  40. ncbi Hidradenitis suppurativa: a treatment challenge
    Nipa Shah
    Department of Family Medicine, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Am Fam Physician 72:1547-52. 2005
    b>Hidradenitis suppurativa is a chronic, recurrent, debilitating disease that presents with painful, inflamed lesions in the apocrine-gland-bearing areas of the body, most commonly the axillary, inguinal, and anogenital areas...
  41. ncbi Hidradenitis suppurativa complicated by squamous cell carcinoma
    Constantinos Constantinou
    Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Am Surg 74:1177-81. 2008
    b>Hidradenitis suppurativa (HS) is a chronic inflammatory condition affecting the apocrine glands of the axilla, groin, and perianal region. Although it is a common condition, it is rarely associated with squamous cell carcinoma (SCC)...
  42. doi Bilateral Candida chorioretinitis following etanercept treatment for hidradenitis suppurativa
    P Arriola-Villalobos
    Eye (Lond) 22:599-600. 2008
  43. ncbi Hidradenitis suppurativa and inflammatory bowel disease: are they associated? Results of a pilot study
    H H van der Zee
    Department of Dermatology and Immunology, Erasmus MC, University Medical Centre, 3015 GE Rotterdam, The Netherlands
    Br J Dermatol 162:195-7. 2010
    Background The co-occurrence of hidradenitis suppurativa (HS) and Crohn disease (CD) published in a few case reports resulted in the wide acceptance of an association between these two diseases...
  44. ncbi Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies
    Jean E Revuz
    AP HP, Groupe Henri Mondor Albert Chenevier, Service de Dermatologie, Creteil, France, Universite Paris 12, Faculte de Medecine, Creteil, France
    J Am Acad Dermatol 59:596-601. 2008
    Conflicting opinions have been reported regarding the epidemiology of hidradenitis suppurativa.
  45. ncbi Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa
    C Lavogiez
    Université de Lille 2 et Clinique de Dermatologie, CHRU de Lille, Lille, France
    Dermatology 220:147-53. 2010
    To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases.
  46. ncbi An open-label phase II study of the safety and efficacy of etanercept for the therapy of hidradenitis suppurativa
    E J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, University General Hospital Attikon, 1 Rimini Str, 124 64 Athens, Greece
    Br J Dermatol 158:567-72. 2008
    To evaluate the safety and efficacy of etanercept for the management of hidradenitis suppurativa.
  47. ncbi Long-term efficacy of a single course of infliximab in hidradenitis suppurativa
    J R Mekkes
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Dermatol 158:370-4. 2008
    b>Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by abscess formation, predominantly in the axillae and groins. The disease is difficult to treat and has a severe impact on quality of life...
  48. ncbi Quality of life impairment in hidradenitis suppurativa: a study of 61 cases
    Pierre Wolkenstein
    Department of Dermatology, Hopital Henri Mondor, AP HP, Paris XII University, Creteil, France
    J Am Acad Dermatol 56:621-3. 2007
    We sought to determine quality of life impairment in hidradenitis suppurativa.
  49. ncbi Impact of Toll-like receptor-4 and tumour necrosis factor gene polymorphisms in patients with hidradenitis suppurativa
    A Savva
    Fourth Department of Internal Medicine, Attikon University Hospital, 1, Rimini str, P C 12462, Athens, Greece
    Br J Dermatol 168:311-7. 2013
    Recent evidence has suggested that deranged immune responses play a role in the pathogenesis of hidradenitis suppurativa (HS).
  50. ncbi Chronic hidradenitis suppurativa in the inguinal, perineal and scrotal regions. A case report and review of the literature
    Daniele Pironi
    Department of Surgical Sciences, Sapienza University of Rome, Roma, Italy
    Ann Ital Chir 81:465-70. 2010
    b>Hidradenitis suppurativa is a chronic, recurrent, debilitating disease that presents with inflamed lesions in the apocrine glands of the body. The most common locations are the axillary, inguinal and anogenital areas...
  51. ncbi Surgical approach to extensive hidradenitis suppurativa
    Oktay Buyukasik
    Department of General Surgery, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey
    Dermatol Surg 37:835-42. 2011
    b>Hidradenitis suppurativa (HS) is a chronic suppurative disease of skin with high recurrence.
  52. ncbi Hidradenitis suppurativa and Crohn's disease: response to treatment with infliximab
    F Martinez
    Department of Gastroenterology and Hepatology, Hospital La Fe, Valencia, Spain
    Inflamm Bowel Dis 7:323-6. 2001
    Cutaneous manifestations occur frequently in inflammatory bowel disease. The association between hidradenitis suppurativa (HS) and Crohn's disease (CD) has been reported. We present a new case supporting this association...
  53. ncbi No human leukocyte antigen-A, -B or -DR association in Swedish patients with hidradenitis suppurativa
    J Lapins
    Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden
    Acta Derm Venereol 81:28-30. 2001
    b>Hidradenitis suppurativa (HS) is a cicatrizing, inflammatory and recurrent disease restricted to inverse skin, such as that of the axilla and groin of younger adults...
  54. ncbi Mild to moderate hidradenitis suppurativa treated with local excision and primary closure
    D C van Rappard
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Eur Acad Dermatol Venereol 26:898-902. 2012
    b>Hidradenitis suppurativa (HS) is a chronic skin disease with a great impact on quality of life. Treatment with antibiotics or anti-inflammatory drugs, such as prednisone or TNF-alpha-inhibitors usually achieves only temporary improvement...
  55. ncbi Mooren's-type ulceration associated with severe hidradenitis suppurativa: a case report and literature review
    Seth W Meskin
    Eye Physicians and Surgeons PC, 202 Cherry Street, Milford, CT 06460, USA
    Ocul Immunol Inflamm 19:340-2. 2011
    To report a case of bilateral Mooren's-type corneal ulcers associated with severe hidradenitis suppurativa.
  56. ncbi Depression in patients with hidradenitis suppurativa
    A J Onderdijk
    Department of Dermatology, Deventer Hospital, Rotterdam, Netherlands
    J Eur Acad Dermatol Venereol 27:473-8. 2013
    b>Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory skin disease with abscess formation and scarring predominantly in the inverse areas...
  57. ncbi Effective long-term control of refractory hidradenitis suppurativa with adalimumab after failure of conventional therapy
    Monika Arenbergerova
    Department of Dermatovenereology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Int J Dermatol 49:1445-9. 2010
    b>Hidradenitis suppurativa is a chronic suppurative condition featuring inflammatory nodules, fistulas and scars. It occurs predominantly in the axillae and groin...
  58. ncbi Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa
    Christoph Schlapbach
    Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland
    J Am Acad Dermatol 65:790-8. 2011
    b>Hidradenitis suppurativa is a debilitating chronic disease primarily affecting intertriginous skin of the axillae, perineum, and inframammary regions. The pathogenesis of this inflammatory disease is still poorly understood...
  59. ncbi Long-term efficacy of infliximab in hidradenitis suppurativa
    Sabela Paradela
    Department of Dermatology, University Hospital of La Coruña, La Coruna, Spain
    J Dermatolog Treat 23:278-83. 2012
    b>Hidradenitis suppurativa (HS) is a chronic disease with painful, inflamed lesions in the apocrine gland-bearing areas of the body and unsatisfactory treatment...
  60. pmc Risk factors for hidradenitis suppurativa: a pilot study
    Juliano Vilaverde Schmitt
    Hospital Universitário Evangélico de Curitiba Faculdade Evangélica do Paraná HUEC FEPAR Curitiba PR, Brazil
    An Bras Dermatol 87:936-8. 2012
    The hidradenitis suppurativa is a chronic debilitating inflammatory disease whose etiology is not fully understood...
  61. ncbi Systemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review
    J L Blok
    Department of Dermatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Br J Dermatol 168:243-52. 2013
    b>Hidradenitis suppurativa (HS) is a difficult disease to treat...
  62. ncbi Treatment of hidradenitis suppurativa by photodynamic therapy with aminolevulinic acid: preliminary results
    Eric S Schweiger
    Department of Dermatology, Mount Sinai Medical Center, New York, NY
    J Drugs Dermatol 10:381-6. 2011
    The current standard of care for hidradenitis suppurativa (HS) includes antibiotics (oral/topical), retinoids (oral/topical) and intralesional steroids and is unsatisfactory...
  63. ncbi Management of severe anogenital acne inversa (hidradenitis suppurativa)
    Uwe Wollina
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden Friedrichstadt, Dresden, Germany
    Dermatol Surg 38:110-7. 2012
    ..Severe anogenital acne inversa (AI) is a debilitating chronic inflammatory disease with a major negative effect on quality of life...
  64. ncbi Adalimumab (antitumour necrosis factor-α) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study
    H H van der Zee
    Departments of Dermatology Immunology, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Br J Dermatol 166:298-305. 2012
    b>Hidradenitis suppurativa (HS) is a difficult-to-manage disease. Randomized controlled trials with antitumour necrosis factor (TNF)-α biologics have been conducted and in most studies disease activity was reduced...
  65. ncbi Histopathologic study of hidradenitis suppurativa following long-pulsed 1064-nm Nd:YAG laser treatment
    Lisa Y Xu
    Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA
    Arch Dermatol 147:21-8. 2011
    To assess clinical and histopathologic changes occurring after long-pulsed 1064-nm Nd:YAG laser treatment of hidradenitis suppurativa (HS).
  66. ncbi Outcomes of treatment of nine cases of recalcitrant severe hidradenitis suppurativa with carbon dioxide laser
    V Madan
    Laser Division, The Dermatology Centre, Salford Royal Hospital NHS Foundation Trust, Stott Lane, Salford, Manchester M6 8HD, UK
    Br J Dermatol 159:1309-14. 2008
    b>Hidradenitis suppurativa (HS) is a chronic and often a recalcitrant inflammatory skin condition.
  67. ncbi Suggestions for uniform outcome variables when reporting treatment effects in hidradenitis suppurativa
    K Sartorius
    Br J Dermatol 149:211-3. 2003
  68. ncbi Increased serum tumour necrosis factor-alpha in hidradenitis suppurativa patients: is there a basis for treatment with anti-tumour necrosis factor-alpha agents?
    Lukasz Matusiak
    Department of Dermatology, Venereology and Allergology, Medical University, Wrocław, Poland
    Acta Derm Venereol 89:601-3. 2009
    b>Hidradenitis suppurativa (HS) is a recurrent, debilitating suppurative skin disease. Nowadays the major challenge is the choice of optimal treatment...
  69. ncbi Hidradenitis suppurativa
    Jean Revuz
    Presse Med 39:1254-64. 2010
    b>Hidradenitis suppurativa, or Verneuil's disease, is somewhat common, especially in women, but it often unrecognized...
  70. ncbi Reactive arthritis associated with hidradenitis suppurativa
    April L Marquardt
    The Ohio State University Division of Immunology Rheumatology, William Davis Medical Research Center, Columbus, Ohio 43210 1228, USA
    J Natl Med Assoc 101:367-9. 2009
    This is a case report of a man with chronic hidradenitis suppurativa who developed reactive arthritis. He presented with swelling and pain in his larger joints, along with conjunctivitis involving his right eye...
  71. ncbi Efficacy of rifampin-moxifloxacin-metronidazole combination therapy in hidradenitis suppurativa
    Olivier Join-Lambert
    Universite Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France
    Dermatology 222:49-58. 2011
    Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments.
  72. ncbi Hidradenitis suppurativa
    Karen M Mitchell
    Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Surg Clin North Am 82:1187-97. 2002
    b>Hidradenitis suppurativa is a chronic, debilitating disease of apocrine gland-bearing skin. Its management must be individualized according to the site and extent of the disease...
  73. ncbi Hidradenitis suppurativa: a disease of the absent sebaceous gland? Sebaceous gland number and volume are significantly reduced in uninvolved hair follicles from patients with hidradenitis suppurativa
    S Kamp
    Department of Dermatology, Roskilde Hospital, 4000 Roskilde, Denmark
    Br J Dermatol 164:1017-22. 2011
    The pathogenesis of hidradenitis suppurativa (HS) is not clearly understood...
  74. ncbi Negative-pressure dressings in the treatment of hidradenitis suppurativa
    E T Elwood
    Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA
    Ann Plast Surg 46:49-51. 2001
    ..b>Hidradenitis suppurativa (HS) is a chronic infection of the apocrine sweat glands...
  75. ncbi [Lymphedema as a complication of hidradenitis suppurativa in three patients]
    O Faye
    Service de Dermatologie, Hopital Henri Mondor, Creteil
    Ann Dermatol Venereol 134:567-9. 2007
    We report three patients (respectively 36, 52 and 52 years old) with a long history of hidradenitis suppurativa associated with pubic lymph oedema.
  76. ncbi Deroofing: a tissue-saving surgical technique for the treatment of mild to moderate hidradenitis suppurativa lesions
    Hessel H van der Zee
    Departments of Dermatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Am Acad Dermatol 63:475-80. 2010
    b>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease, often refractory to treatment. Patients with HS and dermatologists are in need of an effective, fast surgical intervention technique...
  77. ncbi Scanner-assisted carbon dioxide laser surgery: a retrospective follow-up study of patients with hidradenitis suppurativa
    Jan Lapins
    Karolinska Institutet, Department of Medicine, Section of Dermatology and Venereology, Huddinge University Hospital, Stockholm, Sweden
    J Am Acad Dermatol 47:280-5. 2002
    The chronic fistulating lesions of hidradenitis suppurativa spread by contiguous growth, and all affected tissue needs to be surgically removed.
  78. ncbi Experience with ustekinumab for the treatment of moderate to severe hidradenitis suppurativa
    W P Gulliver
    Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland NewLab Life Sciences, Incorporated, St John s, NL, Canada
    J Eur Acad Dermatol Venereol 26:911-4. 2012
    b>Hidradenitis suppurativa (HS) is a severe chronic inflammatory follicular disease characterized by nodules and abscesses affecting apocrine gland-bearing regions...
  79. ncbi Treatment of severe recalcitrant hidradenitis suppurativa with adalimumab
    Viola Harde
    Department of Dermatology, Allergy and Venereology, University Clinic Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 7, Kiel, Germany
    J Dtsch Dermatol Ges 7:139-41. 2009
    b>Hidradenitis suppurativa is a chronic inflammatory skin disease featuring inflammatory nodules, fistulas and discharge of secretions in the intertriginous regions. Without therapy the disease is chronic and progressive...
  80. ncbi Hidradenitis suppurativa: an update
    Robert A Lee
    Hospital of the University of Pennsylvania, Department of Dermatology, 3600 Spruce St, 2 Maloney, Philadelphia, PA 19104, USA
    Adv Dermatol 23:289-306. 2007
    ..Often a multidisciplinary approach involving dermatology, plastic surgery, gynecology, and urology may be necessary to diagnose and treat the disease. Both medical and surgical options should be explored before embarking on therapy...
  81. ncbi Inversa acne (hidradenitis suppurativa): a case report and identification of the locus at chromosome 1p21.1-1q25.3
    Min Gao
    Institute of Dermatology and Department of Dermatology at No 1 Hospital, Anhui, Medical University, Hefei, Anhui, China
    J Invest Dermatol 126:1302-6. 2006
    Acne inversa (hidradenitis suppurativa) is a chronic relapsing inflammatory skin disease characterized by recurrent draining sinuses and abscesses, predominantly in skin folds that carry terminal hairs and apocrine glands...
  82. ncbi Hidradenitis suppurativa
    F William Danby
    Dartmouth Medical School, Hanover, NH, USA
    Dermatol Clin 28:779-93. 2010
    b>Hidradenitis suppurativa (HS) is a chronic, inflammatory, scarring condition involving the intertriginous skin of the axillary, inguinal, inframammary, genital, and perineal areas of the body...
  83. ncbi New-onset polyarthritis during successful treatment of hidradenitis suppurativa with infliximab
    D C van Rappard
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Dermatol 165:194-8. 2011
    b>Hidradenitis suppurativa (HS) can be associated with several forms of arthritis, usually considered as reactive arthritis...
  84. ncbi Hidradenitis suppurativa managed with adalimumab
    Paul S Yamauchi
    Dermatology Institute and Skin Care Center, Santa Monica, CA 90404, USA
    J Drugs Dermatol 8:181-3. 2009
    b>Hidradenitis suppurativa (HS), a chronic, inflammatory, relapsing disease of the apocrine glands in the skin, commonly occurs in women aged 20 to 40 years...
  85. ncbi Pedicled gracilis myocutaneous flap for treatment of recalcitrant hidradenitis suppurativa of the groin and perineum
    N S Solanki
    Clinical School of Medicine, Cambridge University, Cambridge, UK
    J Wound Care 18:111-2. 2009
    ..Use of this flap achieved immediate closure of a complex groin wound following a radical excision. The patient recovered quickly and was pleased with the aesthetic results, while there was no sign of recurrence at three-month follow-up...
  86. ncbi Expression of innate defense antimicrobial peptides in hidradenitis suppurativa
    Silke C Hofmann
    Department of Dermatology, University Freiburg Medical Center, Freiburg, Germany
    J Am Acad Dermatol 66:966-74. 2012
    b>Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of apocrine gland-bearing skin. It is associated with alterations in innate immunity and frequent bacterial infections.
  87. ncbi Efficacy of infliximab for hidradenitis suppurativa: assessment of clinical and biological inflammatory markers
    Maïa Delage
    Department of Dermatology, University Francois Rabelais Tours CHRU Tours, Tours, France
    Acta Derm Venereol 91:169-71. 2011
    Treatment of hidradenitis suppurativa (HS) is often unsatisfactory. The efficacy of infliximab for treatment of the disease has been suggested...
  88. ncbi A double-blind placebo-controlled randomized trial of adalimumab in the treatment of hidradenitis suppurativa
    I Miller
    Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Roskilde 4000, Denmark
    Br J Dermatol 165:391-8. 2011
    b>Hidradenitis suppurativa (HS) has an impact on patients' quality of life. Treatment of HS is generally unsatisfactory, thus new treatments are needed.
  89. ncbi Treatment of hidradenitis suppurativa with intense pulsed light: a prospective study
    Lyndsey Highton
    Department of Plastic Surgery, Lancashire Teaching Hospitals NHS Foundation Trust, Royal Preston Hospital, Fulwood, Preston, United Kingdom
    Plast Reconstr Surg 128:459-65. 2011
    b>Hidradenitis suppurativa is a chronic skin condition characterized by recurrent inflammation and infection of skin in intertriginous areas containing apocrine glands. Intense pulsed light uses high-energy broad-spectrum light...
  90. ncbi Interobserver variability of clinical scores in hidradenitis suppurativa is low
    K Sartorius
    Section of Dermatology, Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, SE 118 83 Stockholm, Sweden
    Br J Dermatol 162:1261-8. 2010
    b>Hidradenitis suppurativa (HS) is a chronic recurrent disease with scars and sinus tract formation that causes substantial impact on quality of life...
  91. ncbi Bacteriology of hidradenitis suppurativa exacerbations and deep tissue cultures obtained during carbon dioxide laser treatment
    K Sartorius
    Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, SE 118 83 Stockholm, Sweden
    Br J Dermatol 166:879-83. 2012
    Previous studies have shown different bacteria in hidradenitis suppurativa (HS) lesions, but the literature regarding bacteria in acute exacerbation of HS is sparse.
  92. ncbi Alterations in leucocyte subsets and histomorphology in normal-appearing perilesional skin and early and chronic hidradenitis suppurativa lesions
    H H van der Zee
    Departments of Dermatology Immunology Pathology, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Br J Dermatol 166:98-106. 2012
    Current insight into the histopathological course of events during disease progression in hidradenitis suppurativa (HS) is fragmentary.
  93. ncbi Familial acne inversa with acne conglobata in three generations
    P V S Prasad
    Indian J Dermatol Venereol Leprol 74:283-5. 2008
  94. ncbi Long-term results of acitretin therapy for hidradenitis suppurativa. Is acne inversa also a misnomer?
    J Boer
    Department of Dermatology, Deventer Hospital, N Bolkesteinlaan 75, 7416 SE Deventer, The Netherlands
    Br J Dermatol 164:170-5. 2011
    b>Hidradenitis suppurativa (HS) is a distressing chronic inflammatory skin disorder which affects predominantly the groins and axillae...
  95. ncbi Hidradenitis suppurativa and squamous cell carcinoma
    Ilknur Kivanc Altunay
    Dermatology Clinic, Sisli Etfal Research and Teaching Hospital, Istanbul, Turkey
    Dermatol Surg 28:88-90. 2002
    b>Hidradenitis suppurativa is a recurrent, chronic inflammatory disease with complications such as abscesses and sinus tract formations, fistulization, and scarring. Squamous cell carcinoma is rare, and is the most serious complication.
  96. ncbi Hidradenitis suppurativa
    Gregor B E Jemec
    Division of Dermatology, Department of Medicine, Roskilde Hospital, Roskilde, Denmark
    J Cutan Med Surg 7:47-56. 2003
    b>Hidradenitis suppurativa is a clinically defined disease that causes considerable morbidity for patients. The results of recent studies, which have increased the understanding of this disease, are reviewed.
  97. ncbi Incidence of cancer among patients with hidradenitis suppurativa
    J Lapins
    Department of Medicine, Section of Dermatology and Venereology, I43, Karolinska Institutet at Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Arch Dermatol 137:730-4. 2001
    On the basis of some case reports, a relationship has been suggested between hidradenitis suppurativa (HS) and the development of nonmelanoma skin cancer.
  98. ncbi [Fatal epidermoid carcinoma in hidradenitis suppurativa following treatment with infliximab]
    E Maalouf
    Service de Dermatologie, Hopital Henri Mondor, Creteil
    Ann Dermatol Venereol 133:473-4. 2006
  99. ncbi Split-thickness skin grafts and negative-pressure dressings in the treatment of axillary hidradenitis suppurativa
    P J Hynes
    Department of Plastic and Reconstructive Surgery, Mater Misericordiae Hospital, Dublin, Ireland
    Br J Plast Surg 55:507-9. 2002
    ..with negative-pressure dressings for the management of defects following wide surgical excision of severe hidradenitis suppurativa. This technique ensures complete skin-graft take whilst allowing full shoulder mobility, thereby ..
  100. ncbi Etanercept: effective in the management of hidradenitis suppurativa
    C Cusack
    Dermatology Department, Waterford Regional Hospital, Waterford, Ireland
    Br J Dermatol 154:726-9. 2006
    b>Hidradenitis suppurativa (HS) is a chronic suppurative condition which is poorly responsive to treatment and is characterized by significant morbidity...
  101. ncbi Surgical treatment of hidradenitis suppurativa: a 10-year experience
    Richard J Kagan
    Department of Surgery, University of Cincinnati College of Medicine, Ohio, USA
    Surgery 138:734-40; discussion 740-1. 2005
    b>Hidradenitis suppurativa (HS) is a disease of the apocrine sweat glands resulting in chronic wounds with abscesses, sinuses, and fibrosis...

Research Grants2

  1. The Role of Presenilin in Hidradenitis Suppurativa
    Airong Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hidradenitis suppurativa (HS) is a chronic skin disease and severe form of acne (acne inversa). HS affects the apocrine sweat glands that often results in chronically draining sinus tracks and wounds...
  2. Second International Hidradenitis Suppurativa Research Symposium
    Michelle Barlow; Fiscal Year: 2009
    ..and underrepresented minorities will be actively encouraged, and the editor of the home journal of the Hidradenitis Suppurativa Foundation Inc...