Summary: A paraneoplastic syndrome marked by degeneration of neurons in the medial temporal lobe. Clinical features include behavioral changes, HALLUCINATIONS, loss of short term memory, anosmia, AGEUSIA, and DEMENTIA. Circulating anti-neuronal antibodies (anti-Hu; also called ANNA 1) and small cell lung carcinomas are frequently associated with this condition. (From Pathologe 1997 Sep;18(5):406-10; J Int Neuropsychol Soc 1996 Sep;2(5):460-6; Brain 1997 Jun;120(Pt 6):923-8)
Publications231 found, 100 shown here
- Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlatesBeau M Ances
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Brain 128:1764-77. 2005We report seven patients, six from a single institution, who developed subacute limbic encephalitis initially considered of uncertain aetiology. Four patients presented with symptoms of hippocampal dysfunction (i.e...
- Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotoniaSarosh R Irani
Neurosciences Group, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
Brain 133:2734-48. 2010..from mammalian brain tissue have been identified in patients with neuromyotonia, Morvan's syndrome, limbic encephalitis and a few cases of adult-onset epilepsy...
- Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitisAngela Vincent
Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
Brain 127:701-12. 2004..Amongst the differential diagnoses, herpes simplex encephalitis, Korsakoff's syndrome and limbic encephalitis should be considered...
- Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case seriesMeizan Lai
Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Lancet Neurol 9:776-85. 2010Voltage-gated potassium channels are thought to be the target of antibodies associated with limbic encephalitis. However, antibody testing using cells expressing voltage-gated potassium channels is negative; hence, we aimed to identify ..
- AMPA receptor antibodies in limbic encephalitis alter synaptic receptor locationMeizan Lai
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Neurol 65:424-34. 2009To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures.
- GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disordersA Boronat
Servei de Neurologia, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
Neurology 76:795-800. 2011Aminobutyric acid-B receptor antibodies (GABA(B)R-ab) were recently described in 15 patients with limbic encephalitis (LE), associated with small-cell lung cancer (SCLC) or with concurrent glutamic acid decarboxylase (GAD) antibodies...
- Limbic encephalitis - a reviewN E Anderson
Neurology Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand
J Clin Neurosci 15:961-71. 2008The clinical features of limbic encephalitis are diverse and early diagnosis of the disorder is frequently difficult. Four patients with limbic encephalitis are described...
- Antibodies to glutamic acid decarboxylase define a form of limbic encephalitisMichael P Malter
Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
Ann Neurol 67:470-8. 2010..decarboxylase (GAD) have been described in a few patients with temporal lobe epilepsies consistent with limbic encephalitis (LE)...
- Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitisSarosh R Irani
Department of Clinical Neurology, Oxford University, Oxford, UK
Ann Neurol 69:892-900. 2011To describe a distinctive seizure semiology that closely associates with voltage-gated potassium channel (VGKC)-complex/Lgi1 antibodies and commonly precedes the onset of limbic encephalitis (LE).
- Binding deficits in memory following medial temporal lobe damage in patients with voltage-gated potassium channel complex antibody-associated limbic encephalitisYoni Pertzov
Institute of Neurology, University College London, London, UK
Brain 136:2474-85. 2013..Voltage-gated potassium channel complex antibody-associated limbic encephalitis has recently been recognized as a form of treatable autoimmune encephalitis, frequently associated with ..
- Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigenEric Lancaster
Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Lancet Neurol 9:67-76. 2010..Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved...
- Limbic encephalitis in children and adolescentsE Haberlandt
Medical University of Innsbruck, Clinical Department of Pediatrics IV, Division of Neuropediatrics and Inherited Metabolic Diseases, Innsbruck, Austria
Arch Dis Child 96:186-91. 2011b>Limbic encephalitis is rare in people <18 years of age and rarely given a formal diagnosis.
- Clinical, magnetic resonance imaging, and electroencephalographic findings in paraneoplastic limbic encephalitisNicholas D Lawn
Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 78:1363-8. 2003To analyze clinical presentation of and paraclinical test abnormalities in patients with paraneoplastic limbic encephalitis (PLE).
- Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitisTakashi Ichiyama
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
Cytokine 44:149-53. 2008Recently, non-herpetic acute limbic encephalitis (NHALE) was identified as a new subgroup of limbic encephalitis. The immunological pathophysiology of NHALE is still unclear.
- Balloon cells in the dentate gyrus in hippocampal sclerosis associated with non-herpetic acute limbic encephalitisHiroaki Miyahara
Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata 951 8585, Japan
Seizure 20:87-9. 2011..a 32-year-old woman with mesial temporal lobe epilepsy and a precipitating history of non-herpetic acute limbic encephalitis. Histologically, the resected specimen showed features of hippocampal sclerosis with granule cell ..
- Paraneoplastic neurological syndromes: unusual presentations of cancer. A practical reviewTareq Braik
Department of Medicine, John H Stroger, Jr Hospital of Cook County, Chicago, IL, USA
Am J Med Sci 340:301-8. 2010..Paraneoplastic neurological syndromes (PNS) are uncommon and imperfectly understood and, therefore, are frequently underdiagnosed...
- Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodiesH Kawano
Department of Anesthesiology and Clinical Research, National Hospital Organization Zentsuji Hospital, Zentsuji, Japan
Anaesthesia 66:515-8. 2011Paraneoplastic limbic encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-d-aspartate receptor and exhibits various manifestations including ..
- Human limbic encephalitis serum enhances hippocampal mossy fiber-CA3 pyramidal cell synaptic transmissionTatjana Lalic
MRC Anatomical Neuropharmacology Unit, Oxford, UK
Epilepsia 52:121-31. 2011b>Limbic encephalitis (LE) is a central nervous system (CNS) disease characterized by subacute onset of memory loss and epileptic seizures...
- Clinical analysis of anti-Ma2-associated encephalitisJosep Dalmau
Department of Neurology, 3 W Gates, Division of Neuro Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Brain 127:1831-44. 2004..Only 26% had classical limbic encephalitis. Excessive daytime sleepiness affected 32% of the patients, sometimes with narcolepsy-cataplexy and low CSF ..
- Antibodies to CRMP3-4 associated with limbic encephalitis and thymomaA Knudsen
Department of Neurology, Haukeland University Hospital, Bergen, Norway
Clin Exp Immunol 149:16-22. 2007We present a case with subacute limbic encephalitis (LE) and thymoma...
- Limbic encephalitis: a cause of temporal lobe epilepsy with onset in adult lifeChristian G Bien
Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Epilepsy Behav 10:529-38. 2007b>Limbic encephalitis (LE) was described in the 1960s as a clinical-pathological syndrome in adults. Initially, the paraneoplastic form was the center of interest...
- The diagnosis and treatment of limbic encephalitisF Asztely
Section of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
Acta Neurol Scand 126:365-75. 2012The term limbic encephalitis (LE) was first introduced in 1968...
- Anti-N-methyl-D-aspartate receptor antibody limbic encephalitisG M Khadem
Department of Medicine and Psychiatry, Taranaki Base Hospital, New Plymouth, New Zealand
Intern Med J 39:54-6. 2009..Most patients improve with immunosuppressive treatment. Raising awareness of this rare but increasingly reported condition is important, as it is responsive to treatment and potentially reversible...
- Temporal lobectomy for refractory status epilepticus in a case of limbic encephalitisTracy Weimer
Department of Neurology, West Virginia University Hospital, Morgantown, West Virginia 26506 9180, USA
J Neurosurg 109:742-5. 2008The authors report a case of status epilepticus secondary to limbic encephalitis that was successfully treated with temporal lobectomy...
- An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitisS H Wong
Department of Neurology, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK
J Neurol Neurosurg Psychiatry 81:1167-9. 2010Voltage-gated potassium channel antibody-positive limbic encephalitis (VGKC+LE) frequently improves with immunotherapy, although the optimum regimen is unknown...
- Paraneoplastic limbic encephalitisJ M S Pearce
Emeritus Consultant Neurologist, Department of Neurology, Hull Royal Infirmary, Hull, UK
Eur Neurol 53:106-8. 2005
- Limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies mimicking Creutzfeldt-Jakob diseaseJi Yeoun Yoo
Yale Comprehensive Epilepsy Center, New Haven, Connecticut2Department of Neurology, Mount Sinai Hospital, New York, New York
JAMA Neurol 71:79-82. 2014b>Limbic encephalitis that is associated with anti-voltage-gated potassium channel complex (VGKCC) antibodies (VGKCC syndrome) is an autoimmune, usually nonparaneoplastic form of encephalitis that is responsive to immunotherapy...
- Disgust and fear recognition in paraneoplastic limbic encephalitisReiner Sprengelmeyer
School of Psychology, University of St Andrews, Scotland, UK
Cortex 46:650-7. 2010Paraneoplastic limbic encephalitis (PNLE) affects limbic portions of the brain associated with recognition of social signals of emotions. Yet it is not known whether this perceptual ability is impaired in individuals with PNLE...
- Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibodyRamon F Barajas
Department of Radiology, Neuroradiology Section, University of California, San Francisco, California 94143 1207, USA
Epilepsia 51:473-7. 2010..Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay...
- FDG-PET and MRI in potassium channel antibody-associated non-paraneoplastic limbic encephalitis: correlation with clinical course and neuropsychologyS Fauser
Epilepsy Center, University of Freiburg, Freiburg, Germany
Acta Neurol Scand 111:338-43. 2005We report a patient with potassium channel antibody-associated non-paraneoplastic limbic encephalitis (NPLE) in whom repeated fluorodeoxyglucose-positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) are correlated ..
- Anti-Ri antibodies and limbic encephalitis in a patient with carcinoid tumour of the lungAndreas Harloff
J Neurol 252:1404-5. 2005
- Improvement of non-paraneoplastic voltage-gated potassium channel antibody-associated limbic encephalitis without immunosuppressive therapyHeidemarie Gast
Department of Neurology, Inselspital, Bern University Hospital, University Bern, Switzerland
Epilepsy Behav 17:555-7. 2010We describe a 61-year-old patient with clinical evidence of limbic encephalitis who improved with anticonvulsant treatment only, that is, without the use of immunosuppressive agents...
- Limbic encephalitis: an expanding conceptFrancesc Graus
Neurology 70:500-1. 2008
- Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptorsToshika Ohkawa
Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences NIPS, Okazaki 444 8787, Japan Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, Okazaki 444 8787, Japan Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima 890 8544, Japan and Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Chiyoda ku, Tokyo 102 0075, Japan
J Neurosci 33:18161-74. 2013..Here, we focused on a mode of action of LGI1 autoantibodies associated with limbic encephalitis (LE), which is one of acquired epileptic disorders characterized by subacute onset of amnesia and seizures...
- A case of smoldering anti-leucine-rich glioma-inactivated 1 (LGI1) antibody-associated limbic encephalitis with faciobrachial dystonic seizureYuriko Nakaoku
Department of Neurology, Kyoto University Graduate School of Medicine
Rinsho Shinkeigaku 53:706-11. 2013..59-year-old right-handed woman with smoldering leucine-rich glioma-inactivated 1 (LGI1) antibody-associated limbic encephalitis (LE) following faciobrachial dystonic seizures...
- Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis: correlation with autoantibody typesAnnette Baumgartner
Department of Neurology, Albert Ludwigs University Freiburg, Breisacher Str 64, 79106, Freiburg, Germany
J Neurol 260:2744-53. 2013In parallel to the detection of new neuronal autoantibodies, the diagnosis of non-infectious limbic encephalitis has risen...
- Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsyC G Bien
Departments of Epileptology, University of Bonn, Germany
Neurology 55:1823-8. 2000To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm.
- Neuropsychological course of voltage-gated potassium channel and glutamic acid decarboxylase antibody related limbic encephalitisC Frisch
Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
Eur J Neurol 20:1297-304. 2013Autoantibodies (abs) to glutamic acid decarboxylase (GAD) and to voltage-gated potassium channels (VGKC) induce distinct courses of limbic encephalitis, related to MRI findings, seizure outcome and cognition.
- 18F-FDG PET/CT findings in voltage-gated potassium channel limbic encephalitisKoramadai Karuppuswamy Kamaleshwaran
Kovai Medical Centre and Hospital, Coimbatore, India
Clin Nucl Med 38:392-4. 2013b>Limbic encephalitis (LE) can be associated with cancer, viral infection, or be idiopathic. One such rare but treatable form is associated with voltage-gated potassium channel (VGKC) antibodies...
- What should you know about limbic encephalitis?Sara Machado
Neurology Department, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal
Arq Neuropsiquiatr 70:817-22. 2012..Hence, early recognition and prompt initiation of immunotherapies are of great importance...
- Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsyC G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Neurology 69:1236-44. 2007..There have been few studies of adult-onset disease. We recognized that some adult individuals have evidence of limbic encephalitis (LE), an autoimmune condition of adult life, which we proposed might lead directly to this syndrome.
- Autoimmune-mediated encephalitisPhilippe Demaerel
Department of Radiology, University Hospitals K U Leuven, Herestraat 49, 3000 Leuven, Belgium
Neuroradiology 53:837-51. 2011..This report is based on a review of the literature (except the literature in Japanese) and own findings in patients with autoimmune-mediated encephalitis...
- Acute nonparaneoplastic limbic encephalitis in childhood: a case series in JapanHiroshi Sakuma
Department of Child Neurology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
Pediatr Neurol 43:167-72. 2010b>Limbic encephalitis not associated with malignancy was investigated in Japanese children, with particular focus on clinical features distinct from adult cases...
- [Antibodies to glutamate receptor in limbic encephalitis]Yukitoshi Takahashi
National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi ku, Shizuoka, Japan
Brain Nerve 62:827-37. 2010..In non-paraneoplastic, non-herpetic acute limbic encephalitis (NHALE), serum antibodies to GluRepsilon2 (NR2B) were detected in approximately 60% of the patients from ..
- Limbic encephalitis presenting with seizures, anterograde amnesia, and psychosis in a patient seven weeks status post immature ovarian teratoma removalBrian Kleyensteuber
Department of Mental Health, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA
Mil Med 175:616-8. 2010..Based on the clinical picture, the working diagnosis was changed to delirium due to paraneoplastic limbic encephalitis. A course of intravenous immunoglobins (IVIg), and high dose steroids was administered...
- A case of voltage-gated potassium channel antibody-related limbic encephalitisTim Harrower
Addenbrooke s Hospital, Cambridge, UK
Nat Clin Pract Neurol 2:339-43; quiz following 343. 2006..He had become apathetic and uninterested in his family. He had no relevant past medical or family history. General and physical neurological examinations were unremarkable, as was bedside cognitive testing...
- Non-paraneoplastic limbic encephalitis associated with anti-glutamic acid decarboxylase antibodiesSabrina Matà
Department of Neurological and Psychiatric Sciences, University of Firenze, Italy
J Neuroimmunol 199:155-9. 2008b>Limbic encephalitis (LE) is a neurological syndrome that may present in association with cancer, infection, or as an isolate clinical condition often accompanying autoimmune disorders...
- Reversible paraneoplastic limbic encephalitis associated with antibodies to the AMPA receptorL Bataller
Service of Neurology, Hospital Universitari La Fe, Avenida de Campanar 21, 46009 Valencia, Spain
Neurology 74:265-7. 2010
- Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6W W Seeley
Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
Neurology 69:156-65. 2007Acute limbic encephalitis has been reported in the setting of treatment-related immunosuppression and attributed to human herpesvirus-6 (HHV6) infection...
- [Non-herpetic acute limbic encephalitis-like manifestation in a case of Hashimoto's encephalopathy with positive autoantibodies against ionotropic glutamate receptor epsilon2]Akihiro Shindo
Department of Neurology, Mie University Graduate School of Medicine
Rinsho Shinkeigaku 47:629-34. 2007..The tentative clinical diagnosis was non-herpetic acute limbic encephalitis (NHALE), and administration of methylprednisolone improved her conditions...
- Paraneoplastic limbic encephalitis attributable to thymomaMohammed S Chaudhry
Department of Oncology, Addenbrookes Hospital, Cambridge, United Kingdom
J Thorac Oncol 2:879-80. 2007
- Spontaneously resolving seronegative autoimmune limbic encephalitisSouhel Najjar
Departments of Neurology, Pathology Division of Neuropathology, Neurosurgery and Psychiatry, NYU Comprehensive Epilepsy Center, New York University School of Medicine, New York, NY, USA
Cogn Behav Neurol 24:99-105. 2011We describe a patient with seronegative autoimmune limbic encephalitis (SNALE) masquerading as glioma. Brain magnetic resonance imaging (MRI) abnormalities, distinctive pathological findings, and spontaneous remission are highlighted.
- Serial MRI of limbic encephalitisHorst Urbach
Department of Radiology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
Neuroradiology 48:380-6. 2006The aim of the study was to analyze serial magnetic resonance imaging (MRI) scans in patients with various forms of limbic encephalitis (LE) in order to evaluate whether, and at what time point, MRI findings support the diagnosis of LE.
- Plasma exchange for anti GAD associated non paraneoplastic limbic encephalitisGustavo Mazzi
Servizio di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliera Santa Maria degli Angeli Via Montereale 24, 33170 Pordenone, Italy
Transfus Apher Sci 39:229-33. 2008b>Limbic encephalitis (LE) is a neurological syndrome usually presenting in a paraneoplastic form...
- Limbic encephalitis associated with anti-GAD antibody and common variable immune deficiencyCigdem I Akman
Comprehensive Epilepsy Center, Department of Neurology, Division of Pediatric Neurology and Epilepsy, Columbia University College of Physicians and Surgeons, New York, NY, USA
Dev Med Child Neurol 51:563-7. 2009A variety of autoantibodies have been identified with complex neurological disorders including limbic encephalitis. The underlying trigger for the immune-mediated process and the role of autoantibodies in the pathogenesis of limbic ..
- Paraneoplastic limbic encephalitis: case reportS Cakirer
Department of Radiology, Neuroradiology Section, Istanbul Sisli Etfal Hospital, 80220 Istanbul, Turkey
Comput Med Imaging Graph 26:55-8. 2002Paraneoplastic limbic encephalitis, which is also known as the remote neurological effect of cancer, is a rare neurological paraneoplastic disorder that usually presents with changes in mental status and behavioral abnormalities...
- Successful treatment of acute autoimmune limbic encephalitis with negative VGKC and NMDAR antibodiesAnna Modoni
Department of Neuroscience, Catholic University of Sacred Heart, Rome, Italy
Cogn Behav Neurol 22:63-6. 2009To describe a case of acute nonherpetic limbic encephalitis (LE) with negative testing for antibodies directed against onconeuronal and cell membrane antigens, including voltage-gated potassium channels and N-methyl-D-aspartate receptor, ..
- Nonparaneoplastic limbic encephalitis with relapsing polychondritisYasuyuki Ohta
Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
J Neurol Sci 220:85-8. 2004..This is thought to be the first case of RP presenting amnesic syndrome and mental disorder associated with nonparaneoplastic limbic encephalitis involving bilateral hippocampi and amygdaloidal bodies detected by MRI.
- Focal paraneoplastic limbic encephalitis presenting as orgasmic epilepsyC E Fadul
Department of Medicine Sections of Hematology Oncology and Neurology, Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA
J Neurooncol 72:195-8. 2005To report orgasmic epilepsy as a manifestation of paraneoplastic limbic encephalitis in a patient with small cell lung cancer.
- Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature reviewJ M Reid
Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
Scott Med J 54:27-31. 2009The syndrome of limbic encephalitis (LE) associated with antibodies against voltage-gated potassium channels (VGKC-LE) has recently been described. The number of published cases is however small...
- Unusual amnesia in a patient with VGKC-Ab limbic encephalitis: a case studyLuke D Kartsounis
Essex Neurosciences Centre, Queen s Hospital, Romford, Essex, UK
Cortex 47:451-9. 2011..We argue that the reported case broadens the phenomenology of VGKC-Ab limbic encephalitis and raises important theoretical questions about the aetiology of this patient's most unusual memory ..
- Navigation around London by a taxi driver with bilateral hippocampal lesionsEleanor A Maguire
Wellcome Department of Imaging Neuroscience, Institute of Neurology University College London, London, UK
Brain 129:2894-907. 2006....
- Limbic encephalitis and variants: classification, diagnosis and treatmentErdem Tuzun
Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Neurologist 13:261-71. 2007Recent studies suggest that a substantial number of patients with autoimmune limbic encephalitis may improve if properly diagnosed and treated...
- Hypothermia in VGKC antibody-associated limbic encephalitisS Jacob
Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
J Neurol Neurosurg Psychiatry 79:202-4. 2008Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy-responsive central nervous system disorders...
- Asymmetric cerebellar ataxia and limbic encephalitis as a presenting feature of primary Sjögren's syndromeKiren Collison
J Neurol 254:1609-11. 2007
- Reversible limbic encephalitis with antibodies against the membranes of neurones of the hippocampusH Shimazaki
J Neurol Neurosurg Psychiatry 78:324-5. 2007
- Autoimmune limbic encephalitis in 39 patients: immunophenotypes and outcomesL Bataller
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Neurol Neurosurg Psychiatry 78:381-5. 2007About 40% of patients with limbic encephalitis do not have detectable CNS antibodies. Some of these patients have immune-mediated limbic encephalitis, but their frequency is unknown.
- Paraneoplastic limbic encephalitis associated with potassium channel antibodies: value of anti-glial nuclear antibodies in identifying the tumourLuigi Zuliani
J Neurol Neurosurg Psychiatry 78:204-5. 2007
- Electroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitisAndrew Lee
Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA, USA
J ECT 22:267-70. 2006Paraneoplastic limbic encephalitis is a rare disorder that can cause memory loss, confusion, personality change, cognitive dysfunction, and psychosis...
- Course and outcome of acute limbic encephalitis with negative voltage-gated potassium channel antibodiesS R Samarasekera
Royal Victoria Infirmary, Newcastle upon Tyne, UK
J Neurol Neurosurg Psychiatry 78:391-4. 2007b>Limbic encephalitis is a potentially treatable immunological condition...
- Non-herpetic acute limbic encephalitis: cerebrospinal fluid cytokines and magnetic resonance imaging findingsKyoko Asaoka
First Department of Internal Medicine, Kurume University School of Medicine, Kurume
Intern Med 43:42-8. 2004Non-herpetic acute limbic encephalitis (non-herpetic ALE) is regarded as a new subgroup of limbic encephalitis...
- Voltage-gated potassium channel antibodies in limbic encephalitisPatricia Pozo-Rosich
Neurosciences Group, Weatherall Insitute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Ann Neurol 54:530-3. 2003We found voltage-gated potassium channel (VGKC) antibodies in 4 of 15 patients with limbic encephalitis (LE)...
- EBV limbic encephalitis after allogenic hematopoietic stem cell transplantationStephane Kremer
UMR 7191 LINC, Service de Radiologie 2, Hopital Hautepierre, Universite de Strasbourg, CHU de Strasbourg, Strasbourg, France
J Neuroradiol 37:189-91. 2010..We report here a case of post-transplant acute limbic encephalitis (PALE) syndrome that was possibly related to EBV infection...
- Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitisAlex Iranzo
Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer, C Villaroel 170, 08036 Barcelona, Spain
Ann Neurol 59:178-81. 2006Of six patients registered in our center with nonparaneoplastic limbic encephalitis associated with antibodies to voltage-gated potassium channels, the five men had rapid eye movement sleep behavior disorder (RBD) coincident with voltage-..
- Autoantibodies to neuronal surface antigens in thyroid antibody-positive and -negative limbic encephalitisErdem Tuzun
Department of Neurology, Istanbul University, Istanbul Faculty of Medicine, Turkey, Turkey
Neurol India 59:47-50. 2011..However, the presence of Thy-Abs in a cohort of limbic encephalitis (LE) patients and their association with anti-neuronal autoimmunity has not been explored.
- CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravisS E Monstad
Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway
J Neurol Neurosurg Psychiatry 80:241-2. 2009..antibodies are often associated with thymoma or small cell lung cancer and paraneoplastic syndromes such as limbic encephalitis (LE)...
- Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestationsKleopas A Kleopa
Department of Clinical Neurosciences, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, PA, USA
Brain 129:1570-84. 2006..is called Morvan's syndrome (MoS); and CNS manifestations without peripheral involvement is called limbic encephalitis (LE)...
- CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitisS Jarius
Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom
J Neurol Sci 268:74-7. 2008Recently, a new subtype of limbic encephalitis (LE) has been described, serologically characterized by the presence of antibodies against voltage gated potassium channels (VGKC, to be called VGKC-LE)...
- [A child with non-herpetic acute limbic encephalitis]H Yoshikawa
No To Hattatsu 35:429-31. 2003
- Acute limbic encephalitis: a new entity?Yoko Mochizuki
Department of Pathology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
Neurosci Lett 394:5-8. 2006..Recently, these cases have been named "non-herpetic acute limbic encephalitis"...
- Treatment-responsive subacute limbic encephalitis and NMDA receptor antibodies in a manMaria Elena Novillo-López
Department of Neurology, Hospital Ramon y Cajal, Madrid, Spain
Neurology 70:728-9. 2008
- Pitfalls in diagnosing limbic encephalitis - a case reportF Kerling
Epilepsy Center ZEE, Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
Acta Neurol Scand 118:339-42. 2008The syndrome of limbic encephalitis (LE) is characterized by subacute onset of temporal lobe epilepsy, loss of short-term memory, cognitive confusion and psychiatric symptoms.
- Long-term cognitive and MRI findings in a patient with paraneoplastic limbic encephalitisT Benke
Clinic of Neurology, University of Innsbruck, Austria
J Neurooncol 66:217-24. 2004..This case of paraneoplastic encephalitis suggests that the related atrophy may present as a chronic, progressive, multifocal encephalopathy and that the associated cognitive impairments may include several cognitive domains...
- MRI and diffusion MRI in nonparaneoplastic limbic encephalitisR N Sener
Department of Radiology, Ege University Hospital, 35100 Bornova, Izmir, Turkey
Comput Med Imaging Graph 26:339-42. 2002This paper reports an 65-year-old woman with nonparaneoplastic limbic encephalitis. On MRI and diffusion MRI, diffuse and symmetrical, bilateral high-signal lesions were evident in the medial temporal lobes...
- Adenylate kinase 5 autoimmunity in treatment refractory limbic encephalitisErdem Tuzun
Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
J Neuroimmunol 186:177-80. 2007We report two men with limbic encephalitis (LE) refractory to corticosteroids, IVIg and plasma exchange. Both patients had serum/CSF antibodies that reacted with the cytoplasm of neurons...
- Paraneoplastic limbic encephalitis masquerading as chronic behavioural disturbance in an adolescent girlA C W Lee
Departments of Paediatrics, Tuen Mun Hospital, New Territories, Hong Kong, China
Acta Paediatr 92:506-9. 2003..To describe an unusual but treatable cause of behavioural disturbance in adolescence...
- Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibodyM J Thieben
Department of Neurology, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Neurology 62:1177-82. 2004....
- [Limbic encephalitis: a probably under-recognized syndrome]F Graus
Servicio de Neurologia, Hospital Clinic, Barcelona
Neurologia 20:24-30. 2005b>Limbic encephalitis was identified as a clinicopathological entity in 1968. Up to a few years ago, 200 cases were described, most associated with lung cancer and more infrequently with other tumors...
- Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associationsF Graus
Servei de Neurologia, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
Neurology 71:930-6. 2008To report the frequency and type of antibodies against neuronal surface antigens (NSA-ab) in limbic encephalitis (LE).
- Case records of the Massachusetts General Hospital. Case 26-2008. A 26-year-old woman with headache and behavioral changesThomas D Sabin
Department of Neurology, Tufts Medical Center, Boston, USA
N Engl J Med 359:842-53. 2008
- [Paraneoplastic limbic encephalitis and epidermoid carcinoma of the pyriform]M A Sobas
Servicios de Medicina Interna, Hospital de Conxo, Complejo Hospitalario Universitario, Santiago de Compostela CHUS
An Med Interna 23:331-4. 2006Paraneoplastic limbic encephalitis is a syndrome characterised by behaviour changes, short-term memory loss and seizures...
- [Limbic encephalitis--a diagnostic challenge]Anette Storstein
Nevrologisk avdeling, Haukeland Universitetssjukehus, 5021 Bergen
Tidsskr Nor Laegeforen 127:3077-80. 2007The etiology of limbic encephalitis (LE) is often autoimmune. Autoimmune LE is often paraneoplastic and should be suspected in patients with subacute confusional states...
- Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnosesR Scheid
J Neurol 252:1129-32. 2005
- Potassium channel antibodies in two patients with reversible limbic encephalitisC Buckley
Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Ann Neurol 50:73-8. 2001b>Limbic encephalitis (LE) is often associated with lung, thymic, or testicular tumours and antibodies to Hu, CV2, or Ma2 (Ta) antigens. In these cases, it generally has a poor prognosis...
- Paraneoplastic limbic encephalitis in a teenage girl with an immature ovarian teratomaRebecca Stein-Wexler
Department of Radiology, University of California, Davis Medical Center and U C Davis Children s Hospital, Sacramento, CA 95817, USA
Pediatr Radiol 35:694-7. 2005Paraneoplastic limbic encephalitis (PLE) is an unusual disorder that is characterized by the association of clinical limbic system abnormalities with neoplasia, usually malignancy...
- Human herpesvirus 6 limbic encephalitis after stem cell transplantationM S Wainwright
Division of Pediatric Neurology, Children's Memorial Hospital, Northwestern University Medical School, Chicago, IL, USA
Ann Neurol 50:612-9. 2001..Because of its subtle clinical presentation, this syndrome may be underrecognized, but can be diagnosed with appropriate magnetic resonance imaging techniques, EEG monitoring, and cerebrospinal fluid viral studies...
- A new anti-neuronal antibody in a case of paraneoplastic limbic encephalitis associated with breast cancerR Scheid
Day Clinic of Cognitive Neurology, University of Leipzig, and Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
J Neurol Neurosurg Psychiatry 75:338-40. 2004Paraneoplastic neurological syndromes are rare remote effects of different types of cancer. Paraneoplastic limbic encephalitis is a specific syndrome, most often associated with small cell lung carcinoma...
- Paraneoplastic limbic encephalitis--case report and review of literatureSunil K Munshi
Department of Cerebrovascular Medicine and Medicine for the Elderly, Leicester General Hospital, University Hospital of Leicester, Gwendolen Road, Leicester LE5 4PW, UK
Age Ageing 34:190-3. 2005..for his illness could be detected in his lifetime, but at post mortem he was found to have paraneoplastic limbic encephalitis and a bronchogenic tumour...
- Memory lost, memory regained: neuropsychological findings and neuroimaging in two cases of paraneoplastic limbic encephalitis with radically different outcomesT H Bak
MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
J Neurol Neurosurg Psychiatry 71:40-7. 2001OBJECTIVE: To report two cases of paraneoplastic limbic encephalitis (PNLE) with similar clinical presentation, but dramatically different outcome and to highlight the role of neuropsychological and radiological evaluation in PNLE...
- [Recent topics on paraneoplastic neurological syndromes: anti-glycolipid antibodies]Tatsuro Muto
Nihon Naika Gakkai Zasshi 97:1844-50. 2008
- Complicated paraneoplastic neurological syndromes: a report of two patients with small cell or non-small cell lung cancerYukiko Hiasa
First Department of Internal Medicine, University of Tokushima School of Medicine, 3 Kuramoto cho, Tokushima City, Tokushima 770 8503, Japan
Clin Neurol Neurosurg 106:47-9. 2003..Patient 1 showed paraneoplastic limbic encephalitis (PLE), paraneoplastic sensory neuropathy (PSN) and Lambert-Eaton myasthenic syndrome (LEMS) associated with ..
- Paraneoplastic Disorders of CNS: Autoantigen ProfilingJosep Dalmau; Fiscal Year: 2007..identification of autoantigens specific for the three most common PNDs of the CNS: cortical and limbic encephalitis, cerebellar degeneration, and brainstem encephalitis...
- Immune evasion in a humanized mouse model of HHV-6 infectionAmy W Hudson; Fiscal Year: 2013..HHV-6 also reactivates in hematopoietic cell transplant recipients, resulting in poor neurocognitive outcome and can result in acute limbic encephalitis (3,4).
- Experimental Dysautonomia: Pathogenesis and TreatmentSteven Vernino; Fiscal Year: 2006..unreadable] [unreadable]..
- FMRI/Pathology/Anterior Cingulate/Frontoinsular CortexWILLIAM SEELEY; Fiscal Year: 2007..The proposed research seeks to benefit the public health by clarifying the biological basis of dementia, ultimately promoting earlier diagnosis and better treatments for dementia patients. ..
- Immunity to brain Ma proteins: A remote effect of cancerJosep Dalmau; Fiscal Year: 2007..We initially identified this disorder in men with testicular tumors and brainstem and limbic encephalitis (LE: memory deficits, seizures, sleep disorders) who developed antibodies to neuronal proteins expressed by ..