- Anthracycline cardiotoxicity: from bench to bedside
Division of Medical Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Instituto Nazionale Tumori, Milan, Italy
J Clin Oncol 26:3777-84. 2008
..Here, we incorporate these discussions into the framework of a broader review of preclinical and clinical issues...
- Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
M E R O'Brien
Kent Cancer Center, Maidstone, UK
Ann Oncol 15:440-9. 2004
- Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
G d Annunzio University School of Medicine, Centro Studi Sull Invecchiamento, Room 412, Via dei Vestini, 66013 Chieti, Italy
Pharmacol Rev 56:185-229. 2004
..An overview of these issues confirms that anthracyclines remain "evergreen" drugs with broad clinical indications but have still an improvable therapeutic index...
- Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
Manuel D Cerqueira
American Society of Nuclear Cardiology, USA
Circulation 105:539-42. 2002
- Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
J Cardiovasc Magn Reson 14:64. 2012
..We hypothesized that quantitative assessment of myocardial ECV would be clinically useful for detecting both focal and diffuse myocardial abnormalities in a variety of common and uncommon heart diseases.
- Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Circulation 117:e25-146. 2008
- Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries
Sarah C Darby
Clinical Trial Service Unit, University of Oxford, Oxford, UK
Lancet Oncol 6:557-65. 2005
..This study aimed to assess the hazards in the general US population from routine cancer-registry and death-certificate data...
- Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery
Jose A Suaya
Schneider Institutes for Health Policy, Heller School MS 035, Brandeis University, Waltham, MA 02454 9110, USA
Circulation 116:1653-62. 2007
..Cardiac rehabilitation (CR) is effective in prolonging survival and reducing disability in patients with coronary heart disease. However, national use patterns and predictors of CR use have not been evaluated thoroughly...
- Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
Erik B Schelbert
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Cardiovasc Magn Reson 13:16. 2011
..Assuming equivalence between techniques, we further hypothesized that Ve measures would be reproducible across scans...
- Cardiac cell repair therapy: a clinical perspective
Bernard J Gersh
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
Mayo Clin Proc 84:876-92. 2009
..An interdisciplinary effort across the scientific and clinical community within academia, biotechnology, and government will drive the successful realization of this next generation of therapeutic agents for the "broken" heart...
- The role of cardiovascular magnetic resonance imaging in heart failure
Theodoros D Karamitsos
University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Am Coll Cardiol 54:1407-24. 2009
..Evidence on the prognostic value of CMR-derived parameters in heart failure is rapidly emerging. This review summarizes the advantages of CMR for patients with heart failure and its important role in key areas...
- Intracellular pH regulation in heart
Richard D Vaughan-Jones
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, Parks Road, OX1 3PT, UK
J Mol Cell Cardiol 46:318-31. 2009
..Such multiple effects emphasise the fundamental role that pHi regulation plays in the heart...
- Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
Martine J Piccart-Gebhart
Medicine Department, Jules Bordet Institute, Blvd de Waterloo 125, 1000 Brussels, Belgium
N Engl J Med 353:1659-72. 2005
..We investigated its efficacy and safety after excision of early-stage breast cancer and completion of chemotherapy...
- Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
D J Slamon
Division of Hematology and Oncology, UCLA School of Medicine, Los Angeles, Calif 90095 1678, USA
N Engl J Med 344:783-92. 2001
..The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30 percent of breast cancers, increasing the aggressiveness of the tumor...
- Endoplasmic reticulum stress as a novel therapeutic target in heart diseases
Boston Biomedical Research Institute, Watertown, MA, USA
Cardiovasc Hematol Disord Drug Targets 7:205-18. 2007
..Importantly, suppression of Puma activity prevented both ER stress and ischemia/reperfusion-induced cardiomyocyte loss, highlighting the ER stress pathways as potential therapeutic targets in cardiovascular diseases...
- Crosstalk between autophagy and apoptosis in heart disease
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Osaka, Japan
Circ Res 103:343-51. 2008
..This review summarizes the evidence for crosstalk between autophagy and apoptosis...
- Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic
Pharmacol Rep 61:154-71. 2009
- Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Su
Charles E Canter
St Louis Children s Hospital, USA
Circulation 115:658-76. 2007
..These events justify a reevaluation of the indications for heart transplantation in congenital heart disease and other causes of pediatric heart failure...
- Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia
Steven E Lipshultz
Department of Pediatrics D820, Miller School of Medicine at the University of Miami, Miami, FL 33101, USA
J Clin Oncol 23:2629-36. 2005
..Cross-sectional studies show that cardiac abnormalities are common in long-term survivors of doxorubicin-treated childhood malignancies. Longitudinal data, however, are rare...
- Drosophila, an emerging model for cardiac disease
Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Gene 342:1-11. 2004
- Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort
Daniel A Mulrooney
University of Minnesota Medical School and Masonic Cancer Center, Minneapolis, MN 55455, USA
BMJ 339:b4606. 2009
..To assess the incidence of and risks for congestive heart failure, myocardial infarction, pericardial disease, and valvular abnormalities among adult survivors of childhood and adolescent cancers...
- Effectiveness of late gadolinium enhancement to improve outcomes prediction in patients referred for cardiovascular magnetic resonance after echocardiography
Timothy C Wong
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Cardiovasc Magn Reson 15:6. 2013
..We assessed whether CMR improves outcomes prediction after contemporaneous echo, which may have implications for efforts to optimize processes of care, assess effectiveness, and allocate limited health care resources...
- Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Munich, Germany
Radiother Oncol 100:160-6. 2011
- Surgical treatment of cardiac hydatid disease in 13 patients
Department of Cardiovascular Surgery, Kosuyolu Heart and Research Hospital, 34846 Kartal, Istanbul, Turkey
Tex Heart Inst J 37:189-93. 2010
..One patient experienced a recurrence 1 year postoperatively. We discuss our surgical approaches, the outcomes in our patients, and diagnostic and therapeutic recommendations...
- Prospective population-based study of RSV-related intermediate care and intensive care unit admissions in Switzerland over a 4-year period (2001-2005)
T M Berger
Children s Hospital of Lucerne, Spitalstrasse, Switzerland
Infection 37:109-16. 2009
..This article reports on all children aged < 3 years who required admission to IMC and/or ICU between October 1, 2001 and September 30, 2005 in Switzerland...
- Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age
Pyotr G Platonov
Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden
J Am Coll Cardiol 58:2225-32. 2011
..The purpose of this study was to assess the association between structural changes in human atria, age, and history of atrial fibrillation (AF)...
- Adult stem cells for cardiac tissue engineering
Eliana C Martinez
Department of Surgery, National University of Singapore, Singapore, Singapore
J Mol Cell Cardiol 50:312-9. 2011
..This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited"...
- Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues
Yosef A Asiri
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
Oxid Med Cell Longev 3:308-16. 2010
- MicroRNAs in cardiac remodeling and disease
Zhan Peng Huang
Cardiovascular Research Division, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA
J Cardiovasc Transl Res 3:212-8. 2010
..In this review, we focus on the recent progress in the understanding of the function of miRNAs in cardiac remodeling and disease. We will also discuss the diagnostic and therapeutic potential of miRNAs in heart disease...
- Liposome-encapsulated doxorubicin in combination with cyclophosphamide, vincristine, prednisone and rituximab in patients with lymphoma and concurrent cardiac diseases or pre-treated with anthracyclines
Department of Hematology, Careggi Hospital and University of Florence, Italy
Hematol Oncol 25:198-203. 2007
- Preventing heart disease by controlling hypertension: impact of hypertensive subtype, stage, age, and sex
Nathan D Wong
Heart Disease Prevention Program, University of California, Irvine, Calif 92697, USA
Am Heart J 145:888-95. 2003
..Hypertension is related to significant morbidity and mortality rates from coronary heart disease (CHD). This report examines the relative and absolute impact on risk for CHD by controlling hypertension to high normal and optimal levels...
- Cardiac rehabilitation in Europe: results from the European Cardiac Rehabilitation Inventory Survey
Institute for Cardiology and Sports Medicine, German Sport University Cologne, Germany
Eur J Cardiovasc Prev Rehabil 17:410-8. 2010
..Information on CR service delivery in Europe is sketchy...
- Program participation and physical activity maintenance after cardiac rehabilitation
Beth C Bock
Miriam Hospital, Center for Behavioral and Preventive Medicine, Brown University School of Medicine, USA
Behav Modif 27:37-53. 2003
..05). Results suggest that Phase III maintenance programs and longer Phase II participation improved exercise maintenance following rehabilitation...
- Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma
Dawn L Hershman
Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Clin Oncol 26:3159-65. 2008
..We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL)...
- Cardiac magnetic resonance imaging in systemic sclerosis: a cross-sectional observational study of 52 patients
A L Hachulla
Department of Cardiovascular Radiology, Regional University Hospital, Lille 2 University, Lille, France
Ann Rheum Dis 68:1878-84. 2009
..To assess the prevalence and patterns of cardiac abnormalities as detected by cardiac magnetic resonance imaging (MRI) in systemic sclerosis (SSc)...
- Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane
Yi Lisa Lyu
Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
Cancer Res 67:8839-46. 2007
- Relationship between retinal arteriolar narrowing and myocardial perfusion: multi-ethnic study of atherosclerosis
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Hypertension 51:119-26. 2008
..This finding suggests that retinal arteriolar narrowing may serve as a marker of coronary microvascular disease...
- Giving learners the best of both worlds: do clinical teachers need to guard against teaching pattern recognition to novices?
Tavinder K Ark
Program for Educational Research and Development, MDCL 3522, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5
Acad Med 81:405-9. 2006
..The purpose of this study was to compare the diagnostic accuracy achieved upon receiving instruction to use each strategy in isolation to that of a combined approach...
- Radiation dose-volume effects in the heart
Department of Medical Physics, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
Int J Radiat Oncol Biol Phys 76:S77-85. 2010
..The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury...
- Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary
Angiogenesis Research Center, BIDMC, Harvard Medical School, Boston, MA, USA
Circulation 102:E73-86. 2000
- Remodelling of gap junctions and connexin expression in diseased myocardium
Nicholas J Severs
National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
Cardiovasc Res 80:9-19. 2008
- Logistic risk model for prolonged ventilation after adult cardiac surgery
Shekar L C Reddy
Department of Cardiothoracic Surgery, The Cardiothoracic Centre Liverpool, Liverpool, United Kingdom
Ann Thorac Surg 84:528-36. 2007
..The aim of this study was to develop a multivariate risk prediction model for prolonged ventilation after adult cardiac surgery...
- Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 296:H1466-83. 2009
..Thus, peroxynitrite is a major trigger of DOX-induced cell death both in vivo and in vivo, and the modulation of the pathways leading to its generation or its effective neutralization can be of significant therapeutic benefit...
- Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
Edward H Romond
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
N Engl J Med 353:1673-84. 2005
..We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer...
- MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
Eva van Rooij
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
J Clin Invest 117:2369-76. 2007
- Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway
Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202 5225, USA
Circulation 119:99-106. 2009
..The cardiotoxic effects of doxorubicin are cumulative, which limits its chemotherapeutic dose. Free radical generation and p53-dependent apoptosis are thought to contribute to doxorubicin-induced cardiotoxicity...
- Clinical trials for stem cell therapies
California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 9107, USA
BMC Med 9:52. 2011
..At the same time, the first three trials using cells derived from pluripotent cells have begun...
- Extension of murine life span by overexpression of catalase targeted to mitochondria
Samuel E Schriner
Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA
Science 308:1909-11. 2005
..These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals...
- Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice
Institute of Pathophysiology, Dept of Medicine, Semmelweis Univ, Budapest, 1089 Nagyvárad tér 4, Hungary
Am J Physiol Heart Circ Physiol 299:H386-95. 2010
..These findings may provide a mechanism explaining accelerated atherosclerosis in patients with elevated plasma TGFbeta(1)...
- Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial
Pharmacology Department, Pitie Salpetriere Hospital, Paris, France
Circulation 103:1428-33. 2001
..beta-Blockade-induced benefit in heart failure (HF) could be related to baseline heart rate and treatment-induced heart rate reduction, but no such relationships have been demonstrated...
- Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
N Engl J Med 354:809-20. 2006
..We compared docetaxel with vinorelbine for the adjuvant treatment of early breast cancer. Women with tumors that overexpressed HER2/neu were also assigned to receive concomitant treatment with trastuzumab or no such treatment...
- Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy
Department of Cardiology and Pneumology, Charité Universitä tsmedizinBerlin, Campus Benjamin Franklin, Berlin, Germany
Diabetes 58:1373-81. 2009
..The underlying pathology of this disease is still under discussion. We studied the role of the kinin B1 receptor on the development of experimental diabetic cardiomyopathy...
- S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products
John H Boyd
Critical Care Research Laboratories, St Paul Hospital, University of British Columbia, Vancouver, Canada
Circ Res 102:1239-46. 2008
..This finding provides a novel mechanistic link between circulating pathogen-associated molecular products and subsequent cardiac dysfunction...
- Autophagy in load-induced heart disease
Beverly A Rothermel
Departments of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
Circ Res 103:1363-9. 2008
..Here, we review recent studies of cardiomyocyte autophagy in load-induced disease and address molecular mechanisms and unanswered questions...
- Molecular and cellular mechanisms of anthracycline cardiotoxicity
Department of Molecular Medicine, Boston University, Boston, TN, USA
Cardiovasc Toxicol 7:114-21. 2007
- NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity
Department of Pharmacology, University Mainz, D 55101 Mainz, Germany
Circulation 112:3754-62. 2005
..There are no data on pharmacogenomic predictors of ACT...
- Evaluation of right ventricular volume and function by 2D and 3D echocardiography compared to MRI
Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark
Eur J Echocardiogr 7:430-8. 2006
- Predicting sudden death in the population: the Paris Prospective Study I
Service de cardiologie, Hopital Boucicaut, Paris, France
Circulation 99:1978-83. 1999
..Therefore, we assessed risk factors, including parental sudden death, associated with the occurrence of sudden death in a long-term cohort study...
- Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure
University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
Circulation 98:2709-15. 1998
..Local handgrip exercise has previously been shown to enhance endothelium-dependent vasodilation in conduit and resistance vessels in CHF...
- The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries
Ravi G Assomull
Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London SW3 6NP, UK
Eur Heart J 28:1242-9. 2007
..However, some patients have no coronary obstruction on angiography, leading to diagnostic uncertainty. We evaluated the incremental diagnostic value of cardiovascular magnetic resonance (CMR) in these patients...
- Endogenous cardiac stem cells
Department of Experimental Medicine, Cenci Bolognetti Foundation, Pasteur Institute, University La Sapienza, Rome, Italy
Prog Cardiovasc Dis 50:31-48. 2007
- Caveolins and heart diseases
Department of Anesthesiology, University of California, San Diego, CA, USA
Adv Exp Med Biol 729:145-56. 2012
..Furthering our understanding of the role for caveolins in cardiovascular pathophysiology has the potential to lead to the manipulation of caveolins as novel therapeutic targets...
- Gap junction alterations in human cardiac disease
Nicholas J Severs
Cardiac Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
Cardiovasc Res 62:368-77. 2004
- Stem cell therapy in heart diseases: a review of selected new perspectives, practical considerations and clinical applications
CBRC, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
Curr Cardiol Rev 7:201-12. 2011
..We also discuss how research with stem cell transplantation could translate to improvement of cardiac function...
- Quantification of myocardial extracellular volume fraction in systemic AL amyloidosis: an equilibrium contrast cardiovascular magnetic resonance study
Sanjay M Banypersad
The Heart Hospital, London, UK
Circ Cardiovasc Imaging 6:34-9. 2013
..We used equilibrium contrast cardiovascular magnetic resonance (EQ-CMR) to quantify the cardiac interstitial compartment, measured as myocardial extracellular volume (ECV) fraction, hypothesizing it would reflect amyloid burden...
- C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women
Paul M Ridker
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Mass 02215, USA
Circulation 107:391-7. 2003
..All of these attributes, however, are associated with increased levels of C-reactive protein (CRP)...
- The roles of microRNAs in heart diseases: a novel important regulator
Department of Pharmacology, Harbin Medical University, Baojian Road 157, Nangang District, Harbin, Heilongjiang Province 150081, PR China
Curr Med Chem 17:407-11. 2010
..These exciting findings not only improve our understanding of the molecular mechanisms of heart diseases, but also provide a new class of potential molecular targets...
- Cardiac rehabilitation uptake and its determinants in the Netherlands
Mariëtte van Engen-Verheul
University of Amsterdam, Amsterdam, The Netherlands
Eur J Prev Cardiol 20:349-56. 2013
..The aims of the present study were to assess CR uptake rates in the Netherlands, and to identify factors that determine uptake...
- Spectrum of heart disease associated with murine and human GATA4 mutation
Satish K Rajagopal
Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
J Mol Cell Cardiol 43:677-85. 2007
..Additional studies will be required to determine the degree to which GATA4 mutation contributes to human CHD characterized by ECD or RV hypoplasia...
- Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?
Douglas B Sawyer
Department of Medicine, Vanderbilt University, Nashville, TN, USA
Prog Cardiovasc Dis 53:105-13. 2010
..Moreover, assessing an individual's risk for anthracycline injury may be improved by having some measure of endogenous activity of this and other myocardial protective signals...
- Participating or not in a cardiac rehabilitation programme: factors influencing a patient's decision
Cedric De Vos
Deloitte Life Sciences and Healthcare, Brussels, Belgium
Eur J Prev Cardiol 20:341-8. 2013
..The objective of this study was to investigate patient compliance with cardiac rehabilitation and the reasons of refusing or abandoning the programme...
- Late valvular and other cardiac diseases after different doses of mediastinal radiotherapy for Hodgkin disease in children and adolescents: report from the longitudinal GPOH follow-up project of the German-Austrian DAL-HD studies
Department of Pediatric Hematology and Oncology, University Hospital Munster, Munster, Germany
Pediatr Blood Cancer 55:1145-52. 2010
..To analyze the impact of mediastinal irradiation on the incidence of cardiac late effects in long-term survivors of pediatric Hodgkin disease (HD)...
- Quantitative evaluation of regional left ventricular function using three-dimensional speckle tracking echocardiography in patients with and without heart disease
University of Chicago, Chicago, Illinois, USA
Am J Cardiol 104:1755-62. 2009
..In conclusion, this is the first study to evaluate the new 3D-STE technique for measurement of regional wall motion indexes. Our findings have demonstrated its superiority over 2D-STE...
- [Retinal vascular signs: a window to the heart?]
Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
Rev Esp Cardiol 64:515-21. 2011
..Retinal photography provides long-lasting records that enable monitoring of longitudinal changes in these retinal signs and vascular health. Full English text available fromwww.revespcardiol.org...
- Opposing cardiac effects of autoantibody activation of β-adrenergic and M2 muscarinic receptors in cardiac-related diseases
Cardiology and the Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma 73104, USA
Int J Cardiol 148:331-6. 2011
..However, the interactions and relative effects of AAβ1AR, AAβ2AR and AAM2R on contractile function have not been characterized...
- 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial
Royal Marsden Hospital, London, UK
Lancet 369:29-36. 2007
..We investigated the drug's effect on overall survival after a median follow-up of 2 years in the Herceptin Adjuvant (HERA) study...
- Standing at the crossroads between new and historically prevalent heart disease: effects of migration and socio-economic factors in the Heart of Soweto cohort study
Preventative Cardiology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Eur Heart J 32:492-9. 2011
..Migration, urbanization, and change in socio-economic factors have potentially profound effects on heart disease in low-to-middle income countries...
- Recombinant human acid alpha-glucosidase enzyme therapy for infantile glycogen storage disease type II: results of a phase I/II clinical trial
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Genet Med 3:132-8. 2001
..Further study will be needed to assess the overall potential of this therapy...
- Accuracy of computerized outpatient diagnoses in a Veterans Affairs general medicine clinic
Herbert C Szeto
Department of Veterans Affairs, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
Am J Manag Care 8:37-43. 2002
- ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline
Andrew E Epstein
Circulation 117:e350-408. 2008
- Health-related quality of life and exercise tolerance in recipients of heart transplants and left ventricular assist devices: a prospective, comparative study
Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
J Heart Lung Transplant 30:204-10. 2011
..The aim of this study was to evaluate and compare health-related quality of life (HRQoL) and physical exercise tolerance in patients after heart transplantation (HTx) or implantation of a left ventricular assist device (LVAD)...
- Cardiotoxicity of cancer therapy
Justin D Floyd
University of Missouri Columbia, Ellis Fischel Cancer Center, 115 Business Loop 70 W, Columbia, MO 65203, USA
J Clin Oncol 23:7685-96. 2005
..We review herein the various syndromes of cardiac toxicity that are reported to be associated with antineoplastic agents and discuss their putative mechanisms and treatment...
- Outcome of listing for cardiac transplantation for failed Fontan: a multi-institutional study
Division of Pediatric Cardiology, Stanford University, 750 Welch Rd, Suite 305, Palo Alto, California 94304, USA
Circulation 114:273-80. 2006
..The purpose of this study was to determine risk factors for death awaiting transplantation and to examine results after transplantation in Fontan patients...
- The impact of intra-operative transoesophageal echocardiography on cardiac surgical practice
A A Klein
Department of Anaesthesia and Critical Care, Papworth Hospital, Cambridge, UK
Anaesthesia 64:947-52. 2009
..025). In these cases, intra-operative echocardiography was specifically requested by the surgeon to help determine the operative intervention. This has implications for consent and operative risk, which have yet to be fully determined...
- Autophagy in disease: a double-edged sword with therapeutic potential
Division of Pharmacology, University of Antwerp, B 2610 Antwerp, Belgium
Clin Sci (Lond) 116:697-712. 2009
..Recently, it has been shown that autophagy can be intensified by specific drugs. The pharmacological modulation of the autophagic pathway represents a major challenge for clinicians to treat human disease...
- Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease
Development and Aging Program, Del E Webb Neuroscience, Aging and Stem Cell Research Center NASCR, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:19833-8. 2008
..These findings suggest that the fly heart might serve as an identifier of candidate genes involved in human heart disease...
- Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
Jane W Newburger
Pediatrics 114:1708-33. 2004
..Coronary artery aneurysms or ectasia develop in approximately 15% to 25% of untreated children and may lead to ischemic heart disease or sudden death...
- Biomarkers in acute cardiac disease: the present and the future
Allan S Jaffe
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic and Medical School, Rochester, Minnesota 55905, USA
J Am Coll Cardiol 48:1-11. 2006
..Finally, it reflects on some of the large number of markers that are still in development...
- Partial loss of GATA factor Pannier impairs adult heart function in Drosophila
NASCR Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Hum Mol Genet 18:3153-63. 2009
- Myofilament dysfunction in cardiac disease from mice to men
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
J Muscle Res Cell Motil 29:189-201. 2008
- The MacNew heart disease health-related quality of life instrument: reference data for users
National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT
Qual Life Res 11:173-83. 2002
..To report reference data for the heart-specific MacNew Heart Disease Health-Related Quality of Life instrument...
- Cardiac regeneration
Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
J Am Coll Cardiol 47:1769-76. 2006
..These cell classes hold promise for the treatment of heart failure in humans...
- Predictors of severe stroke: influence of preexisting dementia and cardiac disorders
Department of Neurology, Orebro University Hospital, Orebro, Sweden
Stroke 33:2357-62. 2002
..We included prestroke dementia, along with other risk factors, to determine independent predictors of stroke severity and early death in a community-based stroke study...
- Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease
Department of Cardiology, Pneumology and Angiology, Heinrich Heine University, Dusseldorf, Germany
Hypertension 36:220-5. 2000
..These findings indicate the beneficial reparative effects of ACE inhibition on coronary microcirculation in hypertensive heart disease...
- Stem cell therapy for heart diseases
Abdul M Mozid
Department of Cardiology, The London Chest Hospital, UK
Br Med Bull 98:143-59. 2011
..Left ventricular systolic dysfunction, a major determinant of prognosis, is associated with significant loss of cardiomyocytes which was previously thought to be irreversible as the heart was considered a post-mitotic organ...
- A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, China
Microvasc Res 80:158-65. 2010
..PKC-beta inhibitor RBX prevented chronic cardiac microvascular barrier dysfunction and improved endothelial cell-cell junctional function in high glucose states...
- Left ventricular torsion: an expanding role in the analysis of myocardial dysfunction
Iris K Rüssel
Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
JACC Cardiovasc Imaging 2:648-55. 2009
..The results obtained over the years are helpful for developing a standardized method to quantify LV torsion and have facilitated the interpretation and value of LV torsion before it can be used as a clinical tool...
- Energy metabolism in the normal and in the diabetic heart
Department of Cardiology, University of Genova, Genova, Italy
Curr Pharm Des 15:836-40. 2009
..In diabetic patients with ischemic heart disease, the effects of modulation of FFA metabolism could even give greater benefit than in nondiabetic patients...
- The developmental genetics of congenital heart disease
Benoit G Bruneau
Gladstone Institute of Cardiovascular Disease, and Department of Pediatrics, University of California San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
Nature 451:943-8. 2008
..Recent studies have uncovered the genetic basis for some common forms of the disease and provide new insight into how the heart develops and how dysregulation of heart development leads to disease...
- Guidelines on the diagnosis and management of pericardial diseases executive summary; The Task force on the diagnosis and management of pericardial diseases of the European society of cardiology
Department of Internal Medicine Cardiology, Philipps University, Marburg, Germany
Eur Heart J 25:587-610. 2004
- Cardiac hydatid disease: CT and MRI findings
Department of Radiology, Istanbul University, Istanbul Faculty of Medicine, Millet Caddesi, Capa, Istanbul, 34390 Turkey
AJR Am J Roentgenol 190:226-32. 2008
..The purpose of this article is to review the CT and MRI findings of cardiac hydatid disease...