Genomes and Genes
carotid artery diseases
Summary: Diseases of the common, internal, and external carotid arteries. ATHEROSCLEROSIS and trauma are relatively frequent causes of carotid artery pathology.
Publications283 found, 100 shown here
- The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional studyHiroyuki Ito
Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan
Cardiovasc Diabetol 9:18. 2010....
- Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysisMatthias W Lorenz
Johann Wolfgang Goethe University, Department for Neurology, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
Circulation 115:459-67. 2007..Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association...
- Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006P J Touboul
Cerebrovasc Dis 23:75-80. 2007..This will help to improve the power of randomized clinical trials incorporating IMT measurements and to facilitate the merging of large databases for meta-analyses...
- Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver diseaseGiovanni Targher
Division of Internal Medicine and Diabetes Unit, Ospedale Sacro Cuore Don Calabria, Via Sempreboni 5, 37024 Negrar Vr, Italy
Diabetes Care 29:1325-30. 2006....
- Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS)Matthias W Lorenz
Department of Neurology, Johann Wofgang Goethe University, Frankfurt am Main, Germany
Stroke 37:87-92. 2006..Carotid intima-media thickness (IMT) is an independent predictor of vascular events in age groups >45 years. However, there is little information about the predictive value of IMT in younger individuals...
- Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritisCarlos Gonzalez-Juanatey
Division of Cardiology, Hospital Xeral Calde, Lugo, Spain
Semin Arthritis Rheum 38:366-71. 2009..To establish whether carotid intima-media wall thickness (IMT) may be a good predictor for the development of cardiovascular (CV) events in patients with rheumatoid arthritis (RA)...
- Association between arterial stiffness and atherosclerosis: the Rotterdam StudyN M van Popele
Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam (Netherlands
Stroke 32:454-60. 2001..CONCLUSIONS: This population-based study shows that arterial stiffness is strongly associated with atherosclerosis at various sites in the vascular tree...
- Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysisPierre Amarenco
Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, 46 rue Henri Huchard, 75018 Paris, France
Stroke 35:2902-9. 2004..Statin trials have now included >90,000 patients. We have determined the effect of statins and LDL-C reduction on stroke prevention...
- Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imagingJian Ming Cai
Department of Radiology, University of Washington, Seattle, Wash 98195 7115, USA
Circulation 106:1368-73. 2002..The purpose of this study was to determine whether in vivo high-resolution multicontrast MRI could accurately classify human carotid atherosclerotic plaque according to the American Heart Association classification...
- Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)Moise Desvarieux
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn, USA
Circulation 111:576-82. 2005..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and subclinical atherosclerosis...
- Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetesHye Jin Yoo
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Cardiovasc Diabetol 10:103. 2011..Omentin-1 is a recently discovered novel adipokine, so data about the relationship of this adipokine to vascular health in type 2 diabetes is limited...
- In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaquesC Yuan
Department of Radiology, University of Washington, Seattle, WA 98195, USA
Circulation 104:2051-6. 2001..The purpose of this study was to evaluate differential contrast-weighted images, specifically a multispectral MR technique, to improve the accuracy of identifying the lipid-rich necrotic core and acute intraplaque hemorrhage in vivo...
- Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population studyS Kiechl
Departments of Neurology, University Clinic Innsbruck, Innsbruck, Austria
Circulation 103:1064-70. 2001..CONCLUSIONS: The present study provides solid evidence for a role of common chronic infections in human atherogenesis. Induction of systemic inflammation and autoimmunity may be potential pathophysiological links...
- Segment-specific associations of carotid intima-media thickness with cardiovascular risk factors: the Coronary Artery Risk Development in Young Adults (CARDIA) studyJoseph F Polak
Department of Radiology, 299, Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA
Stroke 41:9-15. 2010....
- Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control studyAngel Brea
Lipid Clinic, Internal Medicine Service, Hospital San Millán San Pedro, Logrono, Spain
Arterioscler Thromb Vasc Biol 25:1045-50. 2005..Nonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia. We examined whether NAFLD was associated with atherosclerosis, as measured by ultrasound in the carotid arteries...
- Fatty liver index, gamma-glutamyltransferase, and early carotid plaquesMichaela Kozakova
Department of Internal Medicine, University of Pisa, Pisa, Italy
Hepatology 55:1406-15. 2012..g., body mass index, waist circumference, plasma triglycerides, and GGT), the independent determinants of plaque presence were age (P < 0.001), GGT (P = 0.001), and current smoking (P < 0.05)...
- Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 SurveyTeemu Koivistoinen
Department of Clinical Physiology, University of Tampere and Tampere University Hospital, FI 33521, Tampere, Finland
Atherosclerosis 220:387-93. 2012....
- High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritisMiguel A Gonzalez-Gay
Divisions of Rheumatology and Cardiology, Hospital Xeral Calde, Lugo, Spain
J Rheumatol 32:1219-23. 2005..We examined the relationship between carotid IMT to C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which are the most commonly assessed markers of inflammatory response in patients with RA...
- Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individualsNobukazu Ishizaka
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Arterioscler Thromb Vasc Biol 25:1038-44. 2005....
- Dietary intervention to reverse carotid atherosclerosisIris Shai
Department of Epidemiology and Health Systems Evaluation, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
Circulation 121:1200-8. 2010..It is currently unknown whether dietary weight loss interventions can induce regression of carotid atherosclerosis...
- Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosisINMACULADA DEL RINCON
University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Arthritis Rheum 52:3413-23. 2005..To estimate the contribution of cardiovascular (CV) risk factors and rheumatoid arthritis (RA) disease manifestations to atherosclerosis in RA...
- Prevalence of the metabolic syndrome in Latin America and its association with sub-clinical carotid atherosclerosis: the CARMELA cross sectional studyJorge Escobedo
Medical Research Unit on Clinical Epidemiology, Mexican Social Security Institute, Mexico City, Mexico
Cardiovasc Diabetol 8:52. 2009..Limited information on its prevalence in Latin America is available. The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study included assessment of metabolic syndrome in 7 urban Latin American populations...
- Association of vitamin D insufficiency with carotid intima-media thickness in HIV-infected personsAndy I Choi
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Clin Infect Dis 52:941-4. 2011..If confirmed, these findings support a clinical trial of vitamin D supplementation to reduce cardiovascular events in HIV-infected persons...
- An experimental study on the ultimate strength of the adventitia and media of human atherosclerotic carotid arteries in circumferential and axial directionsZhongzhao Teng
Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
J Biomech 42:2535-9. 2009..50+/-0.22). These measurements of the material strength limits for human atherosclerotic carotid arteries could be useful in improving computational models that assess plaque vulnerability...
- The carotid artery atherosclerosis burden and its relation to cardiovascular risk factors in black and white Africans with established rheumatoid arthritis: a cross-sectional studyAhmed Solomon
Department of Rheumatology, Charlotte Maxeke Johannesburg Academic Hospital, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, PO Box 1012, Melville 2109, Johannesburg, South Africa
J Rheumatol 39:1798-806. 2012..We compared the carotid atherosclerosis burden and its relationships with cardiovascular (CV) risk factors between Africans with RA from a developing black and developed CV population...
- Vascular biomarkers in the prediction of clinical cardiovascular disease: the Strong Heart StudyMary J Roman
Division of Cardiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10021, USA
Hypertension 59:29-35. 2012..These findings support the utility of separate assessment of focal atherosclerosis and intimal-medial thickness in epidemiological studies, trials, and risk stratification protocols...
- Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failureMinoru Yambe
Second Department of Internal Medicine, Tokyo Medical University, Japan
Hypertens Res 27:625-31. 2004..Therefore, increased arterial stiffness is a possible simultaneous risk for atherosclerotic cardiovascular disease and diastolic heart failure in patients with hypertension...
- Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging studyNorihide Takaya
Department of Radiology, University of Washington, Seattle, USA
Circulation 111:2768-75. 2005..We have shown that MRI can accurately identify carotid intraplaque hemorrhage and precisely measure plaque volume. We tested the hypothesis that hemorrhage into carotid atheroma stimulates plaque progression...
- Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Tromsø StudyStein Harald Johnsen
Department of Neurology, University Hospital North Norway, N 9038 Tromsø, Norway
Stroke 38:2873-80. 2007..In this prospective, population-based study, we measured carotid IMT, total plaque area, and plaque echogenicity as predictors for first-ever myocardial infarction (MI)...
- Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patientsFelix Gutierrez
Infectious Diseases Unit, Hospital General Universitario de Elche, Alicante, Spain
AIDS 22:1369-71. 2008..Ankle-brachial index was associated with carotid intima-media thickness. Patients with low ankle-brachial index, but not those with high ankle-brachial index, had high carotid intima-media thickness...
- Validation of 3D ultrasound vessel wall volume: an imaging phenotype of carotid atherosclerosisMicaela Egger
Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
Ultrasound Med Biol 33:905-14. 2007..7% ICC = 0.85, rescan COV = 21.1% ICC = 0.88 and interscan variability, COV = 31.1%, ICC = 0.83), although absolute variances for both phenotypes were very similar (VWV = 90 mm3, TPV = 80 mm3)...
- Carotid atherosclerosis and chronic hepatitis C: a prospective study of risk associationsSalvatore Petta
Sezione di Gastroenterologia, Di Bi M I S, Universita di Palermo, Italia
Hepatology 55:1317-23. 2012..3%) with F3-F4 fibrosis (P = 0.008). By contrast, in patients >55 years the prevalence of carotid plaques was similar in those with or without severe fibrosis (25/43, 58.1% versus 22/43, 51.1%; P = 0.51)...
- Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without history of coronary artery diseaseYoko Irie
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
Atherosclerosis 221:438-44. 2012..However, it is unknown whether ultrasonic assessment of carotid atherosclerosis, including CIMT, improves the prediction ability for CAD over and above conventional coronary risk factors in the diabetic patients...
- A candidate gene study revealed sex-specific association between the OLR1 gene and carotid plaqueLiyong Wang
Dr John T Macdonald Foundation, Department of Human Genetics, Miller School of Medicine, University of Miami, Clinical Research Building, Suite CRB 13, 1120 NW 14th Street, Miami, FL 33136, USA
Stroke 42:588-92. 2011..We sought to examine the sex-dependent associations between genes involved in lipid metabolism and carotid atherosclerotic plaque, a subclinical precursor of stroke...
- Impaired insulin sensitivity is an independent predictor of common carotid intima-media thickness in a population sample of elderly menM Wohlin
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Atherosclerosis 170:181-5. 2003..In conclusion, this study is the first to establish impaired insulin sensitivity, measured by the euglycemic hyperinsulinemic clamp test, as an independent predictor of CCA-IMT in a population-based sample of elderly men...
- Longitudinal predictors of progression of carotid atherosclerosis in rheumatoid arthritisJon T Giles
Columbia University, New York, New York, USA
Arthritis Rheum 63:3216-25. 2011..To explore predictors of change in measures of carotid atherosclerosis among rheumatoid arthritis (RA) patients without known cardiovascular disease (CVD) at baseline...
- Atherosclerotic plaque disruption induced by stress and lipopolysaccharide in apolipoprotein E knockout miceMei Ni
Shandong Univ Qilu Hospital, No 107, Wen Hua Xi Road, Jinan, Shandong 250012, P R China
Am J Physiol Heart Circ Physiol 296:H1598-606. 2009..Plasma fibrinogen levels were remarkably elevated in the stress and stress+LPS groups. In conclusion, stress- and LPS-costimulated apoE(-/-) mice provide a useful model for studies of plaque vulnerability and interventions...
- Sex differences in early carotid atherosclerosis (from the community-based Gutenberg-Heart Study)Christoph Sinning
Department of Medicine 2, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
Am J Cardiol 107:1841-7. 2011..In young subjects without cardiovascular risk factors, normal values for IMT were lower in women compared with men. In contrast, in older subjects, gender differences in IMT became nonsignificant...
- Clinical implication of plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations in patients with advanced carotid atherosclerosisConstantinos Giaginis
Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
Clin Chem Lab Med 48:1035-41. 2010..Recent evidence further suggests that NGAL may play a crucial role in vascular remodeling and plaque instability during the development of atherosclerosis...
- Evidence-based treatment of carotid artery stenosisKate C Young
Department of Neurology, University of Rochester Medical Center, Rochester, New York 14620, USA
Neurosurg Focus 30:E2. 2011..Finally, the choice of revascularization technique is discussed with respect to symptom status. Based on current evidence, CAS should remain limited to specific indications...
- The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø studyMarit Herder
Department of Community Medicine, University of Tromsø, Tromsø, Norway
Cardiovasc Diabetol 11:77. 2012..The metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. In this study, we examine if metabolic syndrome predicts progression of atherosclerosis over 13 years...
- Myeloid-related protein-8/14 is critical for the biological response to vascular injuryKevin Croce
Director, Case Cardiovascular Center, Herman K Hellerstein Professor of Cardiovascular Research, Case Western Reserve University School of Medicine, Division of Cardiovascular Medicine, 11100 Euclid Ave, LKS 3001, Cleveland, OH 44106 5038, USA
Circulation 120:427-36. 2009..Beyond its serving as a risk marker, whether MRP-8/14 participates directly in vascular inflammation and disease remains unclear...
- Ultrasonic echolucent carotid plaques predict future strokesM L Grønholdt
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
Circulation 104:68-73. 2001..We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients...
- Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?Michiel L Bots
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands, and Hopital Broussais Assistance Publique Hopitaux de Paris Faculte de Medecine Rene Descartes, France
Eur Heart J 28:398-406. 2007....
- Carotid plaque area: a tool for targeting and evaluating vascular preventive therapyJ David Spence
Robarts Research Institute and University of Western Ontario, London
Stroke 33:2916-22. 2002..Carotid plaque area measured by ultrasound (cross-sectional area of longitudinal views of all plaques seen) was studied as a way of identifying patients at increased risk of stroke, myocardial infarction, and vascular death...
- Carotid atherosclerosis predicts incident acute coronary syndromes in rheumatoid arthritisMatthew R Evans
Brooke Army Medical Center, Fort Sam Houston, Texas, USA
Arthritis Rheum 63:1211-20. 2011..We undertook this study to determine the extent to which ACS are associated with carotid atherosclerosis in RA...
- Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetesGian Paolo Fadini
Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
Circ Res 108:1112-21. 2011..Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes...
- Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetesQin Li
Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China
Cardiovasc Diabetol 10:72. 2011..We aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes...
- Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction studyDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
Stroke 40:3258-63. 2009..To test that hypothesis, 3D fluid-structure interaction models were constructed based on in vivo MRI data of human atherosclerotic carotid plaques to assess structural stress behaviors of plaques with and without rupture...
- Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderlyP Monica Lind
Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
Atherosclerosis 218:207-13. 2011..Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study...
- Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosisF J Nieto
Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205
Circulation 94:922-7. 1996..Animal studies as well as clinical and cross-sectional epidemiological studies in humans have suggested a possible role of cytomegalovirus (CMV) and other herpesvirus infections in the development of cardiovascular disease...
- The effect of cardiovascular risk factors on the longitudinal evolution of the carotid intima medial thickness in children with type 1 diabetes mellitusRobert Dalla Pozza
Department of Pediatric Cardiology, Ludwig Maximilians University, Marchioninistr, 15, D 81377 Munich, Germany
Cardiovasc Diabetol 10:53. 2011..The aim of this prospective longitudinal study was to evaluate changes in carotid intima media thickness (cIMT) in children and adolescents with type 1 diabetes mellitus (T1DM) using standardized methods...
- Should we consider gestational diabetes a vascular risk factor?S Bo
Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, Italy
Atherosclerosis 194:e72-9. 2007..Post-GDM women, despite being currently free from metabolic abnormalities, showed higher values of markers of endothelial dysfunction and IMT than controls, consistent with an increased future cardiovascular risk...
- Tumor necrosis factor receptor levels are associated with carotid atherosclerosisMitchell S Elkind
Department of Neurology, College of Physicians and Surgeons, Columbia University, and the Columbia Presbyterian Medical Center of New York Presbyterian Hospital, New York, NY, USA
Stroke 33:31-7. 2002..We sought to determine whether tumor necrosis factor-alpha (TNF-alpha) and TNF receptor levels are associated with carotid plaque thickness...
- Metabolic syndrome and carotid intima media thickness in the Health 2000 SurveyKalle Sipilä
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
Atherosclerosis 204:276-81. 2009..The objective of this study was to examine metabolic syndrome as a determinant of CIMT in men and women and to compare the Framingham risk score (FRS) and metabolic syndrome as risk factors for increased carotid atherosclerosis...
- Increased intima-media thickness of the carotid artery wall, normal blood pressure profile and normal left ventricular mass in subjects with primary hyperparathyroidismV Nuzzo
Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
Eur J Endocrinol 147:453-9. 2002..Given the multiple influence of PHPT on the cardiovascular system, this study aimed to assess the effects of PHPT on blood pressure profile, and on features of the heart and arterial vessels in normotensive symptomless patients...
- Carotid artery plaque thickness is associated with increased serum calcium levels: the Northern Manhattan studyMishaela R Rubin
Department of Medicine, Columbia University College of Physicians and Surgeons, PH8W 864, 630 W 168th St, New York, NY 10032, USA
Atherosclerosis 194:426-32. 2007..We investigated the association between serum calcium and carotid plaque thickness, a powerful early predictor of clinical coronary and cerebrovascular events...
- Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inJoost P G Sluijter
Experimental Cardiology Laboratory, University Medical Center, Utrecht, The Netherlands
Stroke 37:235-9. 2006..We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics...
- Incremental predictive value of carotid ultrasonography in the assessment of coronary risk in a cohort of asymptomatic type 2 diabetic subjectsSophie Bernard
Department of Endocrinology, Diabetes, and Nutrition, Unité 11, 28 Ave Doyen Lépine, Hopital Cardiovasculaire Louis Pradel, 69003 Lyon Montchat, France
Diabetes Care 28:1158-62. 2005....
- Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted ratsC Indolfi
Division of Cardiology, University Federico II, and the National Cancer Institute, Naples, Italy
Circulation 103:2980-6. 2001..The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown...
- Combined effects of hemoglobin A1c and C-reactive protein on the progression of subclinical carotid atherosclerosis: the INVADE studyDirk Sander
Department of Neurology, Technical University of Munich, Munich, Germany
Stroke 37:351-7. 2006..We investigated the joint effects of both parameters on early carotid atherosclerosis progression and major vascular events in diabetic and nondiabetic subjects...
- Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and menRobert C Kaplan
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
AIDS 22:1615-24. 2008..To assess the association of HIV infection, HIV disease parameters (including CD4+ T-cell counts, HIV viral load, and AIDS) and antiretroviral medication use with subclinical carotid artery atherosclerosis...
- Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns StudyMarkus Juonala
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Circulation 112:1486-93. 2005..Exposure to risk factors in childhood may have long-term influences on vascular function. We examined the relationship between risk factors identified in childhood and arterial elasticity assessed in adulthood...
- Regression of target organ damage in children and adolescents with primary hypertensionMieczyslaw Litwin
Department of Research, The Children s Memorial Health Institute, Warsaw, 04 730, Poland
Pediatr Nephrol 25:2489-99. 2010..137, β = 0.412, p = 0.03). Standard antihypertensive treatment lowered BP and led to regression of TOD in hypertensive children. Lean body mass increase and decrease in abdominal obesity correlated with TOD regression...
- Prognostic impact of fibrinogen in carotid atherosclerosis: nonspecific indicator of inflammation or independent predictor of disease progression?Schila Sabeti
Department of Angiology, Medical University of Vienna, Austria
Stroke 36:1400-4. 2005..We investigated whether fibrinogen predicts future progression of carotid atherosclerosis, analyzing whether fibrinogen levels add to the prognostic information of other inflammatory parameters...
- Evaluation of postpartum carbohydrate intolerance and cardiovascular risk factors in women with gestational diabetesBaris Akinci
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey
Gynecol Endocrinol 27:361-7. 2011..Antepartum prediction of high risk subjects for the subsequent development of postpartum carbohydrate intolerance and metabolic syndrome seems to be vital to prevent cardiovascular outcomes...
- The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery diseaseSammy Y Chan
Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
J Am Coll Cardiol 42:1037-43. 2003..The goal of this study was to determine the relative prognostic importance of noninvasive measures of endothelial function and atheroma burden in patients with coronary artery disease (CAD)...
- Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteriesStephane S Silvera
Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Atherosclerosis 207:139-43. 2009....
- Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged menT Skoog
The Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
Eur Heart J 23:376-83. 2002....
- Under-representation of women and ethnic minorities in vascular surgery randomized controlled trialsAndrew W Hoel
Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Vasc Surg 50:349-54. 2009..This study describes the reporting of gender and ethnicity data in vascular surgery RCTs and analyzes whether these studies adequately represent our diverse patient population...
- Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosusMary J Roman
Division of Cardiology, Weill Medical College of Cornell University, The Hospital for Special Surgery, New York, NY 10021, USA
N Engl J Med 349:2399-406. 2003....
- A negative correlation between human carotid atherosclerotic plaque progression and plaque wall stress: in vivo MRI-based 2D/3D FSI modelsDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
J Biomech 41:727-36. 2008..637). These pilot studies suggest that both lower PWS and lower FSS may contribute to continued plaque progression and should be taken into consideration in future investigations of diseases related to atherosclerosis...
- Evaluation of metabolic syndrome frequency and carotid artery intima-media thickness as risk factors for atherosclerosis in patients with nonalcoholic fatty liver diseaseCem Aygun
Department of Internal Medicine and Gastroenterology, Kocaeli University, F Kerim Gokay Cad, Erenkoy, Istanbul, Turkey
Dig Dis Sci 53:1352-7. 2008..The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery intima-media thickness (IMT) as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease...
- Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient studyDalin Tang
Worcester Polytechnic Institute, Mathematical Sciences Department 100 Institute Road, Worcester, MA, USA
Biomed Eng Online 8:15. 2009..However, large-scale studies based on in vivo patient data combining mechanical stress analysis, plaque morphology and composition for carotid plaque vulnerability assessment are lacking in the current literature...
- Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitusDavid M Nathan
DCCT EDIC Research Group at Box NDIC DCCT, Bethesda, MD 20892, USA
N Engl J Med 348:2294-303. 2003..We examined the progression of carotid intima-media thickness, a measure of atherosclerosis, in a population with type 1 diabetes...
- Oxidized haemoglobin as antigenic target of cell-mediated immune reactions in patients with carotid atherosclerosisElisabetta Profumo
Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
Autoimmun Rev 8:558-62. 2009..Our findings implicate oxidized Hb as a possible antigenic target of cell-mediated immune responses contributing to inflammation in the pathogenesis of carotid atherosclerosis...
- Determinants of carotid intima-medial thickness in an urban Australian Aboriginal populationPamela J Bradshaw
School of Population Health University of Western Australia, Nedlands, WA 6009, Australia
Atherosclerosis 192:218-23. 2007..We studied the determinants of carotid atherosclerosis in urban-dwelling Australian Aboriginals at high risk of atherosclerotic mortality and morbidity...
- Risk factors for subclinical carotid atherosclerosis among current smokersHeather M Johnson
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Prev Cardiol 13:166-71. 2010..001) were independently associated with carotid plaque presence (model χ(2) =210.7, P<.001). The association between pack-years and carotid plaque was stronger in women (OR, 1.09 per 10 pack-years, P(interaction) =.018)...
- Three-dimensional ultrasound of carotid atherosclerosis: semiautomated segmentation using a level set-based methodE Ukwatta
Biomedical Engineering Graduate Program and Robarts Research Institute, The University of Western Ontario, London, Ontario N6A 3K7, Canada
Med Phys 38:2479-93. 2011..The main purpose of this work was to develop and evaluate a semiautomated segmentation algorithm for delineating the MAB and LIB of the carotid artery from 3D US images...
- Predictors of carotid intima-media thickness progression in young adults: the Bogalusa Heart StudyHeather M Johnson
Division of Cardiovascular Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
Stroke 38:900-5. 2007..Although risk factors for the progression of atherosclerosis in middle-aged and elderly adults are well known, they are less well understood in young adults. CIMT is a validated measure of subclinical atherosclerosis...
- Multi-sequence in vivo MRI can quantify fibrous cap and lipid core components in human carotid atherosclerotic plaquesR A Trivedi
University Department of Radiology, Addenbrooke s Hospital, Cambridge, UK
Eur J Vasc Endovasc Surg 28:207-13. 2004..Risk of thrombo-embolic stroke is thought to be better reflected by carotid plaque composition than by luminal stenosis. We set out to determine whether high resolution MRI was a valid method of quantifying plaque components in vivo...
- Measurement of intima-media thickness vs. carotid plaque: uses in patient care, genetic research and evaluation of new therapiesJ David Spence
Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, ON, Canada N6G 2V2
Int J Stroke 1:216-21. 2006..IMT should not be called 'atherosclerosis': the phenotype being assessed should be specified...
- Early carotid atherosclerosis and cardiac diastolic abnormalities in hypertensive subjectsG Parrinello
Department of Internal Medicine, University of Palermo, Italy
J Hum Hypertens 18:201-5. 2004..This approach might improve the prognostic stratification of hypertensive subjects and it might be suitable to recognize the subset of patients at a higher risk of cardiovascular disease or events early...
- Carotid atherosclerosis and the risk factors in early postmenopausal Chinese womenRuby H Y Yu
Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong
Maturitas 63:233-9. 2009..To describe the distribution of intima-media thickness (IMT) and the prevalence of plaque by carotid segments, walls and sides, and to examine their associated risk factors in asymptomatic, early postmenopausal Chinese women in Hong Kong...
- Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE studyDamiano Baldassarre
Department of Pharmacological Sciences, University of Milan, Italy
Eur Heart J 31:614-22. 2010..This paper reports the results of the baseline analyses aimed at identifying the major determinants of increased carotid IMT (C-IMT)...
- Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient miceQiongzhen Li
Department of Radiology and the Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Stroke 39:166-73. 2008..Quantitative trait locus analysis was performed on an intercross between B6.apoE(-/-) and C3H.apoE(-/-) mice to determine genetic factors contributing to variation in the phenotype...
- Early signs of atherosclerosis are associated with insulin resistance in non-obese adolescent and young adults with type 1 diabetesBjörn Rathsman
Karolinska Institutet, Department of Clinical Science and Education, Sachs Childrens Hospital, Södersjukhuset AB, Stockholm, SE 118 83, Sweden
Cardiovasc Diabetol 11:145. 2012..We aimed to explore the role of insulin sensitivity (Si) as an early factor of atherosclerosis in young type 1 diabetes vs. non-diabetic subjects...
- Trends, complications, and mortality in peripheral vascular surgeryRoman Nowygrod
Columbia Weill Cornell Division of Vascular Surgery, Columbia University, New York, NY, USA
J Vasc Surg 43:205-16. 2006....
- Elevated high-density lipoprotein cholesterol levels are protective against plaque progression: a follow-up study of 1952 persons with carotid atherosclerosis the Tromsø studyStein Harald Johnsen
Institute of Community Medicine, University of Tromsø, N 9037 Tromsø, Norway
Circulation 112:498-504. 2005..In this prospective, population-based ultrasound study, we investigated how HDL cholesterol relates to carotid plaque progression...
- Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathologyAloke V Finn
CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
Arterioscler Thromb Vasc Biol 30:177-81. 2010..Moreover, in most cases measures of plaque area or volume are generally considered better predictors of an inflammatory process consistent with atherosclerotic disease rather than intimal medial thickness...
- Association of elevated fibrinogen and C-reactive protein levels with carotid lesions in patients with newly diagnosed hypertension or type II diabetesEgle Corrado
Department of Internal Medicine, Cardiovascular and Nephro Urological Diseases, University of Palermo, Palermo, Italy
Arch Med Res 37:1004-9. 2006..Inflammation may be important for accelerated progression of atherosclerosis in patients with hypertension or diabetes, but few studies included subjects with early stages of atherosclerosis such as those with asymptomatic carotid lesions...
- Subclinic atherosclerosis and cardiovascular risk factors in HIV-infected children: PERI studyIsabela de C B Giuliano
Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil
Coron Artery Dis 19:167-72. 2008....
- Genetic and nongenetic sources of variation in phospholipid transfer protein activityGail P Jarvik
Department of Medicine Division of Medical Genetics, University of Washington, Seattle, WA, USA
J Lipid Res 51:983-90. 2010..These results demonstrate that PLTP activity is strongly influenced by PLTP region polymorphisms and metabolic factors...
- Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosisSelma M Soyal
Department of Laboratory Medicine, Paracelsus Medical University, Mullner Hauptstr 48, 5020 Salzburg, Austria
Atherosclerosis 216:374-80. 2011..We studied associations of CETP-Taq1B and -514C>T-LIPC polymorphisms with hepatic mRNA levels, and their combined effects on plasma lipids and carotid atherosclerosis...
- Hepatic steatosis is associated with an increased risk of carotid atherosclerosisHenry Volzke
Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Walther Rathenau Str 48, D 17487 Greifswald, Germany
World J Gastroenterol 11:1848-53. 2005..The aim of the present study has been to investigate those relationships...
- Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic strokeJaywant P Parmar
Department of Radiology, University of Virginia Health System, Charlottesville, USA
Circulation 122:2031-8. 2010..Although generally accepted, the relationship between cerebral thromboembolism and in situ atherosclerotic plaque morphology has never been directly observed noninvasively in the acute setting...
- The phosphodiesterase inhibitor cilostazol induces regression of carotid atherosclerosis in subjects with type 2 diabetes mellitus: principal results of the Diabetic Atherosclerosis Prevention by Cilostazol (DAPC) study: a randomized trialNaoto Katakami
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
Circulation 121:2584-91. 2010..However, the efficacy and usefulness of 2 different antiplatelet drugs, aspirin and cilostazol, in the progression of carotid intima-media thickening are unknown...
- Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndromeHyeon Chang Kim
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea
Atherosclerosis 204:521-5. 2009..We examined the association between NAFLD and carotid intima-media thickness (IMT) according to the presence of metabolic syndrome (MetS)...
- Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart StudyTuhina Neogi
Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite X 200, Boston, MA 02118, USA
J Rheumatol 36:378-84. 2009....
- Elevation of serum aminotransferase activity increases risk of carotid atherosclerosis in patients with non-alcoholic fatty liver diseaseChia Chi Wang
Department of Hepatology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan
J Gastroenterol Hepatol 24:1411-6. 2009..The aim of the present study was to investigate whether NAFLD patients with ALT elevation had a higher risk of carotid atherosclerosis...
- Histopathology of carotid atherosclerotic diseaseRenu Virmani
International Registry of Pathology, Inc, Gaithersburg, Maryland, USA
Neurosurgery 59:S219-27; discussion S3-13. 2006....
- Structure-Function Assessment of Carotid Disease by MRFelix Wehrli; Fiscal Year: 2004....
- Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical SequelaeChun Yuan; Fiscal Year: 2013..Moreover, the identification of increased neurological ischemia (silent or overt) despite aggressive medical therapy may substantially alter the management in patients with IPH across all levels of stenosis. ..
- Assessing Microstructure of Carotid Disease with MRI/MRSRonald Wolf; Fiscal Year: 2006..Plaque lipid profile and calcium content will be studied as a means to characterize the lesion and evaluate the association between plaque characteristics and patients' symptomatology. ..
- Assessing the Impact of Rare Polymorphism at CRP on CRP Levels & AtherosclerosisChristopher S Carlson; Fiscal Year: 2010....
- GENCAC - North Carolina Field CenterLynne Wagenknecht; Fiscal Year: 2004..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
- GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASISLynne Wagenknecht; Fiscal Year: 2009..abstract_text> ..
- Epidemiology of Carotid Intima-Medial Thickness (IMT) in AtherosclerosisJoseph Polak; Fiscal Year: 2007..unreadable] [unreadable]..
- BIOBEHAVIORAL FACTORS IN ATHEROSCLEROTIC PROGRESSIONThomas Kamarck; Fiscal Year: 2006..unreadable] [unreadable]..
- 3T Atherosclerotic MRI and Carotid Artery Scoring SystemChun Yuan; Fiscal Year: 2009....
- Progression of sub-clinical AtherosclerosisJoseph Polak; Fiscal Year: 2009..This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers. ..
- Inflammation and Infection as Risk Factors in StrokeMitchell Elkind; Fiscal Year: 2006..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
- Inflammatory Genomics in Human Carotid Artery DiseaseGAIL JARVIK; Fiscal Year: 2006..Genes that are implicated in disease may eventually allow targeted therapy. ..
- Carotid Artery Disease Following Neck Irradiation in Ch*Kathleen Meeske; Fiscal Year: 2006..abstract_text> ..
- Epidemiology of IGF and Cardiovascular EventsRobert Kaplan; Fiscal Year: 2005....
- Procoagulants in Aging CARDIA ParticipantsDavid Green; Fiscal Year: 2009....
- Levels of Inflammatory Markers in Treatment of StrokeMitchell Elkind; Fiscal Year: 2008..abstract_text> ..
- Inflammatory and Infectious Burden and Risk of StrokeMitchell Elkind; Fiscal Year: 2008..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
- Advanced NeuroImaging for Acute Stroke TreatmentMax Wintermark; Fiscal Year: 2007..Invited junior scientists, for whom funding is requested, were selected based on merit. [unreadable] [unreadable] [unreadable]..
- Prediction and Progression of Carotid Artery DiseaseGAIL JARVIK; Fiscal Year: 2009..Aim 3: Pathway evaluation of oxidative loci and phenotypes in prediction of CAAD. ..
- Mechanisms of Atherosclerosis and CVD in HIV+ WomenRobert Kaplan; Fiscal Year: 2009..This investigation will have major implications for the development of strategies to predict, prevent, or reverse atherosclerosis in HIV- infected women. ..
- Genetic Determinants of Subclinical Carotid DiseaseTatjana Rundek; Fiscal Year: 2008..3. To explore a newly developed statistical method to evaluate the overall genetic effects from all candidate genes to obtain "whole-pathway" effects. ..
- Pittsburgh Mind-Body Center-IIKaren Matthews; Fiscal Year: 2008..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..
- Nanoparticles for Molecular MRI of AtherosclerosisZahi Fayad; Fiscal Year: 2008..These studies will provide the basis for future advances in experimental studies of atherosclerogenesis and new clinical applications of non-invasive, in vivo MR imaging of atherosclerotic lesions. [unreadable] [unreadable] [unreadable]..
- CELL SURFACE METABOLISM OF MACROPHAGE DERIVED APO ETheodore Mazzone; Fiscal Year: 2001..In this Specific Aim we will more thoroughly examine the metabolism of LDL and ALDL as it is influenced by the cell surface pool of macrophage derived apo E. ..
- Contraceptive in Women with Prior Gestational DiabetesAnny Xiang; Fiscal Year: 2005..The observational results will also be important to the design of future direct comparisons of different forms of contraception in this high-risk population. ..
- PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMESMary McDermott; Fiscal Year: 2001..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
- MICROSPECT IN TUMOR IMAGINGHARRY STRAUSS; Fiscal Year: 2003..At SKI, an ideal setting for such an instrument, the microSPECT will be an invaluable adjunct to the rapidly expanding small-animal imaging program. ..
- Photothrombotic Brain Infarction and EpileptogenesisKevin Kelly; Fiscal Year: 2005..abstract_text> ..
- ER beta selective agonist coronary protection-menopauseR Hermsmeyer; Fiscal Year: 2005..The new ERbetaA is to be contrasted with PremPro(r) (oral conjugated equine estrogens plus medroxyprogesterone acetate) which failed to provide cardiovascular protection in the Women's Health Initiative. ..
- Lipoprotein Metabolism 2008 Gordon Research ConferenceRobert Hegele; Fiscal Year: 2008..End of Abstract) [unreadable] [unreadable] [unreadable]..
- PROGRESSION OF AORTIC ATHEROMA IN STROKE/TIA PATIENTSSouvik Sen; Fiscal Year: 2004..Designing of future placebo controlled prospective studies aimed at investigating measures that may be used to treat AA in stroke/TIA patients. ..
- Obesity subtypes, adiponectin and incident stroke among postmenopausal womenRachel Wildman; Fiscal Year: 2008..Therefore, this application could have a significant impact on stroke prevention as it relates to appropriate treatment indications for obesity. ..
- Middle Cerebral and Common Artery Occlusion and Poststroke EpilepsyKevin Kelly; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- COGNITIVE AND CEREBROVASCULAR SEQUELAE OF HYPERTENSIONJ Jennings; Fiscal Year: 2004..Successful completion will clarify a) how one major disease of aging reduces intellectual functioning and b) permit a rational choice of clinical regimen to treat this disease while minimizing neuropsychological side effects. ..
- Epidemiology of Subclinical Atherosclerosis in SLELisabeth Scalzi; Fiscal Year: 2008..SLE, an inflammatory and immune-dysregulated disease, may provide an ideal model of CVD. ..
- Study of Carotid Occlusion and Neurocognition (RECON)RANDOLPH MARSHALL; Fiscal Year: 2009....
- Molecular genetics of glucose homeostasis and fatDonald Bowden; Fiscal Year: 2009..g. create an "ultra high density" SNP map of the associated chromosomal region. These new SNPs will be genotyped on the IRASFS DNAs to identify the trait defining alleles. ..
- REFLEXES IN LEFT VENTRICULAR DYSFUNCTIONCHULANI KAPPAGODA; Fiscal Year: 2003....
- PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSIONPATRIC STANTON; Fiscal Year: 2008..The long-term regulation of transmitter release has far-reaching importance to normal synaptic processing dynamics, and controlling pathologic glutamate release during injury or disease. ..
- Macrophage Cholesterol Metabolism and ApoE SynthesisTheodore Mazzone; Fiscal Year: 2007..abstract_text> ..
- Identification of diabetes genes on human chromosome 20Donald Bowden; Fiscal Year: 2009..g. insulin resistance, (3-cell function, etc.). Confirmation of association in multiple populations will justify a more detailed molecular genetic analysis similar to that being proposed for PTPN1. ..
- THE EFFECT OF HMG COA REDUCTASE INHIBITORS ON CBFCOLIN DERDEYN; Fiscal Year: 2002..Positive results from these experiments would support further investigation of a potentially important mechanism of stroke protection applicable to all patients with atherosclerotic coronary and cerebrovascular disease. ..
- CCR2 in Atherosclerosis and Monocyte TraffickingIsrael F Charo; Fiscal Year: 2010..Completion of these studies will deepen our understanding of the role of chemokines in monocyte homeostasis and the importance of macrophage activation in atherosclerotic plaque instability. ..
- 2005 Atherosclerosis Gordon ConferenceIsrael Charo; Fiscal Year: 2005..abstract_text> ..
- Iron and AtherosclerosisSubha Raman; Fiscal Year: 2006..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
- RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROMEEvelyn Talbott; Fiscal Year: 2005..The investigators state that this study has the potential to identify the determinants of early SCA in this high-risk group of women and has important implications for primary as well as secondary prevention. ..
- Atheroclerosis in rheumatoid arthritis cohortINMACULADA DEL RINCON; Fiscal Year: 2005..This would ultimately lengthen life expectancy and improve the quality of life of people with inflammatory diseases. ..
- MOEMS device for fluorescence spectroscopy of tissues and cellsLaura Marcu; Fiscal Year: 2006..The device will widely be applied to various biomedical instruments that require wavelength differentiation and selection. ..
- Non-viral controllable gene delivery for neuroprotectionJAMES HECKER; Fiscal Year: 2007..Neuroprotection strategies designed for pre-operative use will also have significant application for attenuation of secondary injury following stroke, brain or spinal cord trauma, or neurodegenerative diseases. ..
- Vascular Protection in Acute Ischemic StrokeSusan Fagan; Fiscal Year: 2005..Collectively, the successful completion of the research summarized in this proposal can be expected to contribute to the development of methods to make reperfusion safer, and therefore more accessible, to human stroke patients. ..
- Improving Functioning in Peripheral Arterial DiseaseMary McDermott; Fiscal Year: 2007..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
- 2007 Vascular Cell Biology Gordon Research ConferenceBradford Berk; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Biochemical Heterogeneity in Morbidly Obese Women in the WHI Observational StudyRachel Mackey; Fiscal Year: 2008..This will be the first epidemiology study to specifically focus on morbidy obesity Class III unselected for weight reduction, i.e. bariatric surgery, in black and white women. ..
- Fish Oil Intake, Biomarkers and Change in Lung FunctionR Barr; Fiscal Year: 2008..Use of this existing cohort with previously collected blood samples will provide relatively cost-effective results about this potentially promising and safe therapy for COPD. ..
- Protein Kinase C in Macrophage ActivationMICHELLE LENNARTZ; Fiscal Year: 2006..Defining the mechanisms by which PKC transduces the phagocytic signal is critical to our understanding of host defense and the defects that result in autoimmune diseases. ..
- Trends in blood pressure in relation to obesityRebecca Din Dzietham; Fiscal Year: 2005..Research findings would lead to more refined mechanistic studies for ultimately better tailored interventions. ..
- In vivo multichannel fluorescent imagingUmar Mahmood; Fiscal Year: 2007....
- Spatial epidemiology of diabetes in the SEARCH for Diabetes in Youth StudyANGELA LIESE; Fiscal Year: 2009..This effort may provide novel leads for subsequent etiologic studies of pediatric diabetes and will assist health care planners in identifying geographic areas in particular need of health services resources. ..
- Carotid Atherosclerosis (MRI) Progression Study (CAMP)JOHN CROUSE; Fiscal Year: 2008..abstract_text> ..
- STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONRalph Sacco; Fiscal Year: 2007..abstract_text> ..
- MR Spectroscopy of SIV Brain InjuryRamon Gonzalez; Fiscal Year: 2009..Specific Aim 2. Determine the severity of CNS injury by in vivo &ex vivo MRS and immunohistochemistry in different brain regions, and determine the levels of perivascular MPs in those regions. ..
- Inflammatory markers in CVD and OP in SLE womenELISA RHEW; Fiscal Year: 2006..The project outlined in this proposal will provide a strong foundation for achieving my ultimate goal of becoming an independent clinical investigator. [unreadable] [unreadable]..
- In Vivo Assessment of AAA Biomechanics with Dynamic Wall PropertiesENDER FINOL; Fiscal Year: 2008..This methodology is expected to greatly enhance the presurgical planning capabilities of vascular surgeries and endovascular therapies in the future management of cardiovascular diseases. [unreadable] [unreadable] [unreadable]..
- FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTIONCarl Grunfeld; Fiscal Year: 2006..The results will provide essential information on the risk of atherosclerosis and its contributors to aid in patient care, policy and future research. [unreadable] [unreadable] [unreadable]..
- PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRSRamon Gonzalez; Fiscal Year: 2002..abstract_text> ..