eye diseases

Summary

Top Publications

  1. pmc Prevalence of eye diseases in South Korea: data from the Korea National Health and Nutrition Examination Survey 2008-2009
    Kyung Chul Yoon
    Department of Ophthalmology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
    Korean J Ophthalmol 25:421-33. 2011
  2. ncbi Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians
    Raghavan Lavanya
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmic Epidemiol 16:325-36. 2009
  3. ncbi Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES)
    Athena W P Foong
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ophthalmic Epidemiol 14:25-35. 2007
  4. pmc Cyclophosphamide for ocular inflammatory diseases
    Siddharth S Pujari
    The Massachusetts Eye Research and Surgery Institution, Cambridge, Massachusetts, USA
    Ophthalmology 117:356-65. 2010
  5. pmc Obesity and eye diseases
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Surv Ophthalmol 52:180-95. 2007
  6. pmc The prevalence of age-related eye diseases and visual impairment in aging: current estimates
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Invest Ophthalmol Vis Sci 54:ORSF5-ORSF13. 2013
  7. pmc Ocular features of Behcet's disease: an international collaborative study
    Nobuyoshi Kitaichi
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Br J Ophthalmol 91:1579-82. 2007
  8. pmc Structure and biological roles of mucin-type O-glycans at the ocular surface
    Ana Guzman-Aranguez
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Ocul Surf 8:8-17. 2010
  9. pmc Childhood eye diseases in southwestern Nigeria: a tertiary hospital study
    Oluwatoyin Helen Onakpoya
    Ophthalmology Unit, Department of Surgery, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
    Clinics (Sao Paulo) 64:947-52. 2009
  10. ncbi An analysis of effects of San Diego wildfire on ambient air quality
    Shekar Viswanathan
    School of Engineering and Technology, National University, La Jolla, CA 92037, USA
    J Air Waste Manag Assoc 56:56-67. 2006

Research Grants

  1. Recombinant T-cell Receptor Ligands for Treatment of Uveitis
    Grazyna Adamus; Fiscal Year: 2006
  2. Planning a Clinical Trial on Low Vision Rehabilitation
    Cynthia Owsley; Fiscal Year: 2007
  3. Clinical Vision Research Unit at UAB
    Cynthia Owsley; Fiscal Year: 2006
  4. Improving the Quality of Diabetes Eye Care
    Paul Lee; Fiscal Year: 2006
  5. Retinal Microvascular Signs and CVD in Older Persons
    Tien Wong; Fiscal Year: 2005
  6. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
  7. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2008
  8. Gene Therapy of Autosomal Recessive RP
    Simon Petersen Jones; Fiscal Year: 2006
  9. Trends in Use of Eye Care Services for Children
    Michael Ganz; Fiscal Year: 2005
  10. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010

Detail Information

Publications294 found, 100 shown here

  1. pmc Prevalence of eye diseases in South Korea: data from the Korea National Health and Nutrition Examination Survey 2008-2009
    Kyung Chul Yoon
    Department of Ophthalmology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
    Korean J Ophthalmol 25:421-33. 2011
    The aim of this study is to report on preliminary data regarding the prevalence of major eye diseases in Korea.
  2. ncbi Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians
    Raghavan Lavanya
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmic Epidemiol 16:325-36. 2009
    Current knowledge of ethnic variability in the epidemiology of major eye diseases in Asia is limited...
  3. ncbi Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES)
    Athena W P Foong
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ophthalmic Epidemiol 14:25-35. 2007
    ..are approximately 200 million people of Malay ethnicity living in Asia, the burden and risk factors of blinding eye diseases in this ethnic group are unknown...
  4. pmc Cyclophosphamide for ocular inflammatory diseases
    Siddharth S Pujari
    The Massachusetts Eye Research and Surgery Institution, Cambridge, Massachusetts, USA
    Ophthalmology 117:356-65. 2010
    ..To evaluate the outcomes of cyclophosphamide therapy for noninfectious ocular inflammation...
  5. pmc Obesity and eye diseases
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Surv Ophthalmol 52:180-95. 2007
    ..Among different eye diseases, obesity has been linked with age-related cataract, glaucoma, age-related maculopathy, and diabetic retinopathy...
  6. pmc The prevalence of age-related eye diseases and visual impairment in aging: current estimates
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Invest Ophthalmol Vis Sci 54:ORSF5-ORSF13. 2013
    ..To examine prevalence of five age-related eye conditions (age-related cataract, AMD, open-angle glaucoma, diabetic retinopathy [DR], and visual impairment) in the United States...
  7. pmc Ocular features of Behcet's disease: an international collaborative study
    Nobuyoshi Kitaichi
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Br J Ophthalmol 91:1579-82. 2007
    ..To investigate the clinical features of ocular lesions in Behçet's disease in different countries...
  8. pmc Structure and biological roles of mucin-type O-glycans at the ocular surface
    Ana Guzman-Aranguez
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Ocul Surf 8:8-17. 2010
    ..This review summarizes recent advances in understanding the structure, biosynthesis, and function of mucin-type O-glycans at the ocular surface and their alteration in ocular surface disease...
  9. pmc Childhood eye diseases in southwestern Nigeria: a tertiary hospital study
    Oluwatoyin Helen Onakpoya
    Ophthalmology Unit, Department of Surgery, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
    Clinics (Sao Paulo) 64:947-52. 2009
    b>Eye diseases are important cause of medical consultation in children, with the spectrum varying in different localities...
  10. ncbi An analysis of effects of San Diego wildfire on ambient air quality
    Shekar Viswanathan
    School of Engineering and Technology, National University, La Jolla, CA 92037, USA
    J Air Waste Manag Assoc 56:56-67. 2006
    ....
  11. ncbi Development of a Chinese version of the National Eye Institute Visual Function Questionnaire (CHI-VFQ-25) as a tool to study patients with eye diseases in Hong Kong
    C W S Chan
    The Eye Institute, The University of Hong Kong, Room 301, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong
    Br J Ophthalmol 93:1431-6. 2009
    To develop a Chinese version of the National Eye Institute Visual Function Questionnaire (CHI-VFQ-25) and to test its reliability and validity in a group of patients with eye diseases in Hong Kong.
  12. ncbi Mortality and ocular diseases: the Beijing Eye Study
    Liang Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Ophthalmology 116:732-8. 2009
    ..To examine the relationship between mortality and major ocular diseases...
  13. pmc Applying principles of health system strengthening to eye care
    Karl Blanchet
    International Centre for Eye Health, Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Indian J Ophthalmol 60:470-4. 2012
    ..This present paper aims to clarify key concepts in health system strengthening and describe the various components of the framework as applied in eye care interventions...
  14. ncbi Rituximab in refractory ophthalmic Wegener's granulomatosis: PR3 titers may predict relapse, but repeat treatment can be effective
    Lavnish Joshi
    UCL Institute of Ophthalmology, London, United Kingdom
    Ophthalmology 118:2498-503. 2011
    ..To report the long-term outcome of the treatment of refractory ophthalmic Wegener's granulomatosis (WG) with rituximab (RIT), including rates of relapse, predictors of relapse, and results of repeat treatment...
  15. ncbi Vascular endothelial growth factors and angiogenesis in eye disease
    A N Witmer
    Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
    Prog Retin Eye Res 22:1-29. 2003
    ..family of growth factors controls pathological angiogenesis and increased vascular permeability in important eye diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD)...
  16. ncbi Penetration of topical and subconjunctival corticosteroids into human aqueous humour and its therapeutic significance
    M A Awan
    Ophthalmology Department, Tennent Institute of Ophthalmology, Gartnavel General Hospital, 1053 Great Western Rd, Glasgow G12 0YN, UK
    Br J Ophthalmol 93:708-13. 2009
    ..Subconjunctival corticosteroids provide very high concentrations in the aqueous which maintain higher concentrations for longer periods...
  17. ncbi Ocular health status of rural dwellers in south-western Nigeria
    Bernice O Adegbehingbe
    Ophthalmology Unit, Department of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
    Aust J Rural Health 15:269-72. 2007
    ..To determine the prevalence and causes of ocular morbidity, visual impairment and blindness, and suggest strategies for blindness prevention in a rural population...
  18. ncbi Prevalence of vitreoretinal disorders in a rural population of southern India: the Aravind Comprehensive Eye Study
    Praveen K Nirmalan
    Aravind Medical Research Foundation, Aravind Eye Care System, Madurai, India
    Arch Ophthalmol 122:581-6. 2004
    ..To determine the magnitude of vitreoretinal disorders in a rural southern Indian population...
  19. ncbi Prevalence and causes of visual impairment and blindness in an urban Indian population: the Singapore Indian Eye Study
    Yingfeng Zheng
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology 118:1798-804. 2011
    ..To describe the prevalence and causes of visual impairment and blindness in an urban Indian population...
  20. pmc The role of eye-associated lymphoid tissue in corneal immune protection
    Erich Knop
    Research Laboratory of the Eye Clinic CVK, Charite University School of Medicine, Berlin, Germany
    J Anat 206:271-85. 2005
    ..It can detect corneal antigens and prime respective effector cells, or distribute protective factors as secretory IgA...
  21. pmc Prevalence of eye diseases in primary school children in a rural area of Tanzania
    S H Wedner
    Infectious and Tropical Diseases Department, London School of Hygiene and Tropical Medicine, London, UK
    Br J Ophthalmol 84:1291-7. 2000
    The study measured the prevalence of eye diseases in primary school children between 7 and 19 years of age in a rural area of Tanzania, and investigated whether teachers could successfully provide the first component of a school eye ..
  22. ncbi Ocular immune privilege: therapeutic opportunities from an experiment of nature
    J Wayne Streilein
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 3:879-89. 2003
  23. ncbi Vesicular systems in ocular drug delivery: an overview
    Indu P Kaur
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Int J Pharm 269:1-14. 2004
    ....
  24. ncbi Development of the 25-item National Eye Institute Visual Function Questionnaire
    C M Mangione
    Division of General Internal Medicine and Health Services Research, Department of Medicine, UCLA, 911 Broxton Plaza, Box 951736, Los Angeles, CA 90095-1736, USA
    Arch Ophthalmol 119:1050-8. 2001
    ..DESIGN: Prospective observational cohort study of persons with 1 of 5 chronic eye diseases or low vision who were scheduled for nonurgent visits in ophthalmology practices and a reference sample of ..
  25. ncbi Recent perspectives in ocular drug delivery
    Ripal Gaudana
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110 2499, USA
    Pharm Res 26:1197-216. 2009
    ..Current momentum in the invention of new drug delivery systems hold a promise towards much improved therapies for the treatment of vision threatening disorders...
  26. ncbi Tomographic features and surgical outcomes of vitreomacular traction syndrome
    Norihiro Yamada
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Am J Ophthalmol 139:112-7. 2005
    ..To study the relation between preoperative macular changes and surgical outcomes in vitreomacular traction syndrome...
  27. ncbi Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease
    J Sebag
    Clinical Ophthalmology, Doheny Eye Institue, University of Southern California, Los Angeles, CA, USA
    Graefes Arch Clin Exp Ophthalmol 242:690-8. 2004
    ..This would not only facilitate surgery, but if performed early in the natural history of disease, it should prevent progressive disease...
  28. pmc Effects of air pollution and climatic conditions on the frequency of ophthalmological emergency examinations
    T Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France INSERM Unit 444, Saint Antoine Hospital, Paris, France Meteo France, Paris, France
    Br J Ophthalmol 87:809-11. 2003
  29. ncbi Cme review: polymerase chain reaction diagnostics for posterior segment disease
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8096, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Retina 23:445-52. 2003
    ....
  30. ncbi Shared care for chronic eye diseases: perspectives of ophthalmologists, optometrists and patients
    Patricia M O'Connor
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 196:646-50. 2012
    To report the perspectives of optometrists, ophthalmologists and patients on a model of shared care for patients with chronic eye diseases.
  31. ncbi The effects of chronic exposure to traffic derived air pollution on the ocular surface
    Priscila Novaes
    Laboratório de Investigação em Oftalmologia, Faculdade de Medicina, Universidade de Sao Paulo, Av Dr Arnaldo 455, 5th Floor, 01246 903 Sao Paulo, Brazil
    Environ Res 110:372-4. 2010
    ..The purpose of this study was to explore the clinical relevance of chronic exposure to ambient levels of traffic derived air pollution on the ocular surface...
  32. ncbi Applications of liposomes in ophthalmology
    Shehab Ebrahim
    Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Surv Ophthalmol 50:167-82. 2005
    ..Although verteporfin is the only liposomal drug currently approved for use in the eye, the benefits of liposomes will likely be applied widely in all treatment, diagnostic, and research aspects of ophthalmology in the future...
  33. ncbi Mid-level cadre providing eye care in the context of Vision 2020
    Renee du Toit
    The Fred Hollows Foundation New Zealand, Private Bag, Auckland, New Zealand
    N Z Med J 122:77-88. 2009
    ..Establish government recognition, resources, support, and evaluation and feedback systems to ensure that this mid-level cadre can implement their training, and have the opportunity of providing high quality eye care...
  34. ncbi Nanomaterials for ocular drug delivery
    Shengyan Liu
    Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L3G1, Canada
    Macromol Biosci 12:608-20. 2012
    ....
  35. ncbi The Sankara Nethralaya mobile teleophthalmology model for comprehensive eye care delivery in rural India
    Sheila John
    Department of Teleophthalmology, Medical Research Foundation, Sankara Nethralaya, Chennai, India
    Telemed J E Health 18:382-7. 2012
    ..We introduced mobile units for comprehensive eye care delivery and have successfully conducted eye camps over the past 1.5 years...
  36. ncbi Risk of selected eye diseases in people admitted to hospital for hypertension or diabetes mellitus: record linkage studies
    Michael J Goldacre
    Department of Public Health, Unit of Health Care Epidemiology, University of Oxford, Oxford, UK
    Br J Ophthalmol 96:872-6. 2012
    ..Associations among hypertension, diabetes mellitus and some ophthalmic diseases are well established; associations with others are more equivocal. The aim was to quantify associations accurately using large epidemiological datasets...
  37. ncbi Ocular oxyspirurosis of primates in zoos: intermediate host, worm morphology, and probable origin of the infection in the Moscow zoo
    E Ivanova
    Centre of Parasitology of A N Severtsov Institute of Ecology and Evolution, Leninskii pr, 33, 119071 Moscow, Russia
    Parasite 14:287-98. 2007
    ..Consequently the notion of type hosts is artificial and the three agents of oxyspirurosis are provisionally placed in the taxon O. (O.) conjunctivalis...
  38. ncbi Visual impairment, age-related eye diseases, and cognitive function: the Singapore Malay Eye study
    Shin Yeu Ong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Arch Ophthalmol 130:895-900. 2012
    To describe the associations of visual impairment and major age-related eye diseases with cognitive function in an older Asian population.
  39. pmc Perception of blindness and blinding eye conditions in rural communities
    Adeyinka Ashaye
    Department of Ophthalmology, College of Medicine, University of Ibadan, Ibodan, Nigeria
    J Natl Med Assoc 98:887-93. 2006
    ..The purpose of this qualitative study was to explore the causes and management of blindness and blinding eye conditions as perceived by rural dwellers of two Yoruba communities in Oyo State, Nigeria...
  40. pmc Scale for photographic grading of vitreous haze in uveitis
    Janet L Davis
    University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Florida 33136, USA
    Am J Ophthalmol 150:637-641.e1. 2010
    ..To validate a scale for grading vitreous haze in uveitis using digitized photographs and standardized scoring...
  41. ncbi Clinical manifestations of ocular toxoplasmosis
    Emmanuelle Delair
    Universite Paris Descartes, Service d Ophtalmologie, Hopital Cochin, Paris, France
    Ocul Immunol Inflamm 19:91-102. 2011
    ..Acute acquired infections also may be complicated by toxoplasmic retinochoroiditis, with recurrences most common close to the time of acquisition. Suppressive treatment can reduce recurrent disease...
  42. ncbi Alcohol and eye diseases
    Shiqi Wang
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Surv Ophthalmol 53:512-25. 2008
    Alcohol consumption is a modifiable lifestyle factor, but there is uncertainty regarding its association with eye diseases in adults...
  43. ncbi Relationship between vision impairment and eye disease to vision-specific quality of life and function in rural India: the Aravind Comprehensive Eye Survey
    Praveen K Nirmalan
    Aravind Medical Research Foundation, Aravind Eye Care System, Madurai, India
    Invest Ophthalmol Vis Sci 46:2308-12. 2005
    To determine the impact of vision impairment and eye diseases on vision-specific quality of life and visual function in an older population of rural southern India.
  44. ncbi The redox state of human serum albumin in eye diseases with and without complications
    Karl Oettl
    Institute of Physiological Chemistry, Center for Physiological Medicine, Medical University of Graz, Austria
    Acta Ophthalmol 89:e174-9. 2011
    To investigate the redox state of human serum albumin concerning cysteine-34 as a possible systemic redox marker in patients with different eye diseases with and without complications and with consideration of possible effects of age.
  45. ncbi Changing causes of enucleation over the past 60 years
    Vikram J Setlur
    Doheny Eye Institute, University of Southern California, 1450 San Pablo St DVRC 211, Los Angeles, CA 90033, USA
    Graefes Arch Clin Exp Ophthalmol 248:593-7. 2010
    ..The indications for enucleation have changed significantly over the past 60 years. We conducted a clinicopathologic study of enucleated globes to determine how and why the indications for enucleation have changed over time...
  46. ncbi Drug delivery to the posterior segment of the eye
    Thilini Rasika Thrimawithana
    Drug Delivery Research Unit DDRU, School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1010, New Zealand
    Drug Discov Today 16:270-7. 2011
    ..There is an increasing need for managing rapidly progressing posterior eye diseases, such as age-related macular degeneration, diabetic retinopathy and retinitis pigmentosa...
  47. ncbi Reaching rural Africans with eye care services: findings from primary eye care approaches in Rubavu District, Rwanda
    Paul Courtright
    Kilimanjaro Centre for Community Ophthalmology, Good Samaritan Foundation, Moshi, Tanzania
    Trop Med Int Health 15:692-6. 2010
    ..Assessment of a primary eye care programme in rural Rwanda over 2 years, with the aim of providing evidence to guide the development, training, supervision, or monitoring of primary eye care in Africa...
  48. pmc HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Mol Vis 14:550-5. 2008
    ..In this study, we investigated the association between HLA class II antigens in addition to HLA class I antigens and SJS/TEN...
  49. ncbi Retinal vasculitis
    R Christopher Walton
    Department of Ophthalmology, University of Tennessee College of Medicine, Memphis, 38163, USA
    Curr Opin Ophthalmol 14:413-9. 2003
    ..Because retinal vasculitis is an uncommon disease, there are only a limited number of publications over the past year related to this topic...
  50. ncbi A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases
    Yahya E Choonara
    Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, Gauteng, South Africa
    J Pharm Sci 99:2219-39. 2010
    ..technology utilizes engineered materials or devices that could revolutionize the treatment of posterior segment eye diseases by affording localized drug delivery, responding to and interacting with target sites to induce physiological ..
  51. ncbi Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?
    Ilse Krebs
    Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria
    Am J Ophthalmol 144:741-746. 2007
    ..To compare the state of the posterior vitreous in exudative age-related macular degeneration (AMD) with eyes with nonexudative AMD and controls...
  52. ncbi The science behind lutein
    Alexandra Alves-Rodrigues
    Research and Development Department, Kemin Foods Europe, Avenue Visconde Valmor 66, 5 degrees andar, 1050 242 Lisbon, Portugal
    Toxicol Lett 150:57-83. 2004
    ..Evidence suggests that lutein consumption is inversely related to eye diseases such as age-related macular degeneration (AMD) and cataracts...
  53. pmc Utilisation of eye care services in rural south India: the Aravind Comprehensive Eye Survey
    P K Nirmalan
    Lions Aravind Institute of Community Opthalmology, Aravind Eye Care System, Madurai, India
    Br J Ophthalmol 88:1237-41. 2004
    ..To determine utilisation of eye care services in a rural population of southern India aged 40 years or older...
  54. ncbi Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium
    L David Waterbury
    Pacific BioLabs, Hercules, CA 94070, USA
    Curr Med Res Opin 22:1133-40. 2006
    ..To compare the cyclooxygenase (COX) activity and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs (NSAIDs) ketorolac tromethamine (ketorolac) and bromfenac sodium (bromfenac)...
  55. pmc Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Hirokoji, Kawaramachi, Kamigyoku, Kyoto 602 0841, Japan
    Br J Ophthalmol 91:962-5. 2007
    ..The first line of defence against infection is comprised of evolutionarily conserved sets of molecules, the Toll-like receptors (TLRs). TLR3 recognises double-stranded RNA associated with viral infections...
  56. pmc Evaluation of a system for automatic detection of diabetic retinopathy from color fundus photographs in a large population of patients with diabetes
    Michael D Abramoff
    Retina Service, Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Diabetes Care 31:193-8. 2008
    ..To evaluate the performance of a system for automated detection of diabetic retinopathy in digital retinal photographs, built from published algorithms, in a large, representative, screening population...
  57. pmc Understanding and using sensitivity, specificity and predictive values
    Rajul Parikh
    LV Prasad Eye Institute, Banjara Hills, Hyderabad, India
    Indian J Ophthalmol 56:45-50. 2008
    ..We also have illustrated how to calculate sensitivity and specificity while combining two tests and how to use these results for our patients in day-to-day practice...
  58. ncbi Ocular manifestation of storage diseases
    Jyotirmay Biswas
    Department of Ocular Pathology, Medical and Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Curr Opin Ophthalmol 19:507-11. 2008
    ..This is an attempt to provide a brief overview of ocular manifestation of storage diseases (lysosomal storage diseases)...
  59. pmc Ocular morbidity in schoolchildren in Kathmandu
    B P Nepal
    BP Koirala Lions Center for Ophthalmic Studies, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal
    Br J Ophthalmol 87:531-4. 2003
    Any information on eye diseases in schoolchildren in Nepal is rare and sketchy. A programme to provide basic eye screening to schoolchildren with an aim to provide services as well as gather information on ocular morbidity has been started...
  60. ncbi Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study
    Shuang Wang
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Ophthalmology 116:2373-80. 2009
    To assess the relationship of hypertension with major eye diseases and other ocular parameters.
  61. ncbi Free radicals, antioxidants and eye diseases: evidence from epidemiological studies on cataract and age-related macular degeneration
    A E Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Ophthalmic Res 44:191-8. 2010
    ..Most epidemiological studies have been conducted in well-nourished western populations but evidence is now emerging from other populations with different dietary patterns and antioxidant levels...
  62. ncbi PEDF in angiogenic eye diseases
    J Tombran-Tink
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Curr Mol Med 10:267-78. 2010
    ..Its control of a neuroprotective and an antineovascular regulatory axis that determines cell fate, and its possible use in combination therapeutic strategies for ocular neovascular diseases are also reviewed...
  63. ncbi Causes of blindness and visual impairment in a population of older Americans: The Salisbury Eye Evaluation Study
    B Munoz
    Wilmer Eye Institute, The Johns Hopkins University, 600 N Wolfe St, Room 116, Baltimore, MD 21287, USA
    Arch Ophthalmol 118:819-25. 2000
    ..To determine the causes of blindness and visual impairment in a population-based sample of older Americans...
  64. ncbi Prevalence of blindness and low vision in north central, Nigeria
    M Mansur Rabiu
    Community Ophthalmology Department, National Eye Centre, PMB 2267, Kaduna, Nigeria
    West Afr J Med 27:238-44. 2008
    ....
  65. pmc Nutrition and age-related eye diseases: the Alienor (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) Study
    C Delcourt
    INSERM U897, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    J Nutr Health Aging 14:854-61. 2010
    Worldwide, degenerative eye diseases (age-related maculopathy (ARM), cataract, glaucoma) are the main causes of visual impairment and blindness, which contribute to disability in the elderly...
  66. ncbi Clinical and molecular evaluation of probands and family members with familial exudative vitreoretinopathy
    F Nienke Boonstra
    Bartiméus Institute for the Visually Impaired, Zeist, The Netherlands
    Invest Ophthalmol Vis Sci 50:4379-85. 2009
    ..To describe the ophthalmic characteristics and to identify the molecular cause of FEVR in a cohort of Dutch probands and their family members...
  67. ncbi Ocular manifestations and concepts of systemic vasculitides
    Victor L Perez
    Massachusetts Eye and Ear Infirmary, Immunology and Uveitis Service, 243 Charles Street, Boston, MA 02114, USA
    Surv Ophthalmol 49:399-418. 2004
    ..Furthermore, it discusses general concepts in diagnosis and treatment of these diseases in an effort to provide a practical framework for the ophthalmologist evaluating patients with vasculitis...
  68. ncbi Ophthalmologic manifestations of rheumatic diseases
    F Hamideh
    Department of Medicine, University of California, Irvine, Medical Center, Orange, CA, USA
    Semin Arthritis Rheum 30:217-41. 2001
    ..Understanding the varied manifestations of eye disease will permit the rheumatologist to better evaluate the activity of the rheumatic disease...
  69. ncbi Wegener's granulomatosis: the relationship between ocular and systemic disease
    S L Harper
    Department of Ophthalmology, Uveitis and Immunology Service, The Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA
    J Rheumatol 28:1025-32. 2001
    ..CONCLUSION: Ocular inflammation can occur with or without obvious systemic manifestations of WG. It may represent the first sign of WG that enables the knowledgeable physician to diagnose this potentially lethal disease...
  70. pmc Zebrafish: a model system for the study of eye genetics
    James M Fadool
    Department of Biological Science, Graduate Program in Neuroscience, Florida State University, Tallahassee, FL 32312, USA
    Prog Retin Eye Res 27:89-110. 2008
    ..characterization, behavioral approaches and screening strategies, the identification of novel genes or novel gene functions will have important implications for our understanding of human eye diseases, pathogenesis, and treatment.
  71. ncbi Visual acuity, amblyopia, and ocular pathology in 12- to 13-year-old children in Northern Mexico
    Josefin Ohlsson
    Department of Ophthalmology, Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J AAPOS 7:47-53. 2003
    ..The aim of this study was to establish visual acuity (VA) and the prevalence of amblyopia and other ocular disorders in a population of 12- to 13-year-old children in Mexico who have not been vision screened...
  72. ncbi Role of the ubiquitin-proteasome in protein quality control and signaling: implication in the pathogenesis of eye diseases
    Fu Shang
    Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Boston, Massachusetts, USA
    Prog Mol Biol Transl Sci 109:347-96. 2012
    ..of the cytotoxic abnormal proteins in eye tissues is etiologically associated with many age-related eye diseases such as retina degeneration, cataract, and certain types of glaucoma...
  73. pmc Prevalence of eye diseases and causes of visual impairment in school-aged children in Western China
    Lian Hong Pi
    Department of Ophthalmology, Children s Hospital, Chongqing Medical University, People s Republic of China
    J Epidemiol 22:37-44. 2012
    The present study investigated the prevalence of refractive error, visual impairment, and eye diseases in school-aged children in western China.
  74. ncbi Lifestyle strategies for the prevention of vision loss
    Nancy C Sharts-Hopko
    Villanova University, Villanova, PA 19085, USA
    Holist Nurs Pract 24:284-91. 2010
    ..Because vision loss has been shown to be associated with diminished quality of life and increased mortality, lifestyle changes that prevent or moderate the impact of these diseases are an important focus of nursing care...
  75. ncbi Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy
    Prithvi Mruthyunjaya
    Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina 27710, USA
    Ophthalmology 109:1123-9. 2002
    ..To determine the yield of diagnostic pars plana vitrectomy in eyes with suspected posterior segment inflammation or malignancy when clinical examination and systemic laboratory testing did not yield a specific diagnosis...
  76. pmc High-resolution 3D MR microangiography of the rat ocular circulation
    Yen Yu I Shih
    Research Imaging Institute and Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Radiology 264:234-41. 2012
    ..To develop high-spatial-resolution magnetic resonance (MR) microangiography techniques to image the rat ocular circulation...
  77. ncbi Implementation and evaluation of an ophthalmic nurse practitioner emergency eye clinic
    Bradley J Kirkwood
    NH and MRC Centre for Clinical Research Excellence in Ophthalmology Outcomes Research, Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia
    Clin Experiment Ophthalmol 33:593-7. 2005
    ..To describe the implementation and assess the efficacy of an ophthalmic nurse practitioner (ONP) emergency eye clinic...
  78. ncbi Ocular melanosis in the Cairn Terrier: clinical description and investigation of mode of inheritance
    Simon M Petersen-Jones
    Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824 1314, USA
    Vet Ophthalmol 10:63-9. 2007
    ..To describe the clinical features of ocular melanosis in Cairn Terriers...
  79. ncbi Therapeutic potential of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors for the treatment of retinal and eye diseases
    Christian Schmeer
    Department of Neurology, Neuroregeneration Laboratory, University of Jena Medical School, Jena, Germany
    CNS Neurol Disord Drug Targets 6:282-7. 2007
    ..known and putative mechanisms of statin actions underlying neuroprotective effects in relevant retinal and eye diseases. In addition, it presents evidence for the role of heat shock proteins (Hsps) as target of statin-mediated ..
  80. ncbi Prospects for treatment of pediatric vitreoretinal diseases with vascular endothelial growth factor inhibition
    Kristie L Lin
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 24:70-6. 2009
    ..This paper will examine the current evidence for use of anti-VEGF therapy in a number of pediatric vitreoretinal disorders and describe a case of anti-VEGF therapy in retinopathy of incontinentia pigmenti...
  81. ncbi The orbicularis oculi muscle flap: its use for treatment of lagophthalmos and a review of its use for other applications
    F Stagno D'Alcontres
    Plastic Surgery Unit, Messina University, Messina, Italy
    J Plast Reconstr Aesthet Surg 63:416-22. 2010
    ..In this article, the authors describe the treatment of paralytic eye with a static technique using a medially based orbicularis oculi muscle flap (OOMF) from the upper eyelid in patients with lagophthalmos...
  82. ncbi Appropriateness of ophthalmic cases presenting to a Nigerian tertiary health facility: implications for service delivery in a developing country
    A O Mahmoud
    Department of Ophthalmology, University of Ilorin Teaching Hospital, Ilorin, Nigeria
    Niger J Clin Pract 13:280-3. 2010
    ..To assess whether the ophthalmic cases presenting at a Nigerian tertiary eye unit are appropriate for such level of care and also draw necessary implications for service delivery...
  83. ncbi Asteroid hyalosis in a population: the Beaver Dam eye study
    S E Moss
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705-2397, USA
    Am J Ophthalmol 132:70-5. 2001
    ..It does not support previous observations of an association of asteroid hyalosis with diabetes or refractive error. The relevance of the new associations reported (body mass, alcohol) remains to be determined...
  84. ncbi Epidemiology of major eye diseases leading to blindness in Europe: a literature review
    Elena Prokofyeva
    Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    Ophthalmic Res 47:171-88. 2012
    The objective of this work was to study the epidemiology of major eye diseases leading to blindness in Europe through a systematic literature review...
  85. pmc Utilisation of eye care services by urban and rural Australians
    Jill E Keeffe
    Br J Ophthalmol 86:24-7. 2002
    ..To investigate factors related to the use of eye care services in Australia...
  86. ncbi Assessment of human and material resources available for primary eye-care delivery in rural communities of southwestern Nigeria
    O H Onakpoya
    Ophthalmology Unit, Department of Surgery, Obafemi Awolowo University, Ile Ife, Nigeria
    West Indian Med J 58:472-5. 2009
    ..Although procurement of materials and training of health-workers in basic PEC delivery is required, the healthcare facilities and workers currently available are adequate to commence integration of PEC into the PHC system...
  87. ncbi Nurse triage, diagnosis and treatment of eye casualty patients: a study of quality and utility
    John C Buchan
    The London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
    Accid Emerg Nurs 11:226-8. 2003
    ..The incidence of cases of misdiagnosis and inappropriate discharge of patients resulting in a delay in diagnosis and treatment was also assessed...
  88. pmc Ophthalmic admissions in a tertiary hospital in Nigeria
    O H Onakpoya
    Department of Surgery, Obafemi Awolowo University, Ile Ife, Nigeria
    Afr Health Sci 10:54-7. 2010
    ..Hospitalization for eye care is required for different reasons. The pattern of admissions into the ophthalmic wards of a sub-urban tertiary hospital was studied...
  89. ncbi A refillable microfabricated drug delivery device for treatment of ocular diseases
    Ronalee Lo
    Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA
    Lab Chip 8:1027-30. 2008
    ..An implantable manually-actuated microfabricated drug delivery device was demonstrated as a new approach for delivering therapeutic compounds to ocular tissue in acute in vitro, ex vivo, and in vivo studies...
  90. ncbi Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils: consequences for allergic eye diseases
    G Woerly
    Centre d Immunologie et Biologie Parasitaire, Unité INSERM IPL U547, Institut Pasteur, Lille, France
    Allergy 58:397-406. 2003
    ..The aim of this study was to investigate the effects of ketotifen on different parameters of human eosinophil functions, namely chemotaxis, oxidative metabolism and mediator release, induced after activation...
  91. ncbi Clinicopathologic review of pediatric enucleations during the last 50 years
    SUSAN HUANG
    Department of Ophthalmology, Pediatric Ophthalmology and Strabismus, University of California San Francisco, 10 Koret Way, San Francisco, CA 94143, USA
    J AAPOS 14:328-33. 2010
    ..To evaluate diagnoses leading to enucleations in the pediatric age group over time...
  92. ncbi Prevalence of eye disease in early childhood and associated factors: findings from the millennium cohort study
    Phillippa M Cumberland
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London UCL, London, UK
    Ophthalmology 117:2184-90.e1-3. 2010
    ..To report the prevalence and distribution of eye conditions and visual impairment and associations with early social and biological factors using parental report of diagnosed eye conditions and additional chronic illnesses...
  93. pmc Dirofilaria repens in Vietnam: detection of 10 eye and subcutaneous tissue infection cases identified by morphology and molecular methods
    Nguyen Van De
    Department of Parasitology, Hanoi Medical University, Hanoi, Vietnam
    Korean J Parasitol 50:137-41. 2012
    ..repens (Italian origin, GenBank AJ271614; DQ358814). This is the first report of eye dirofilariasis and the second report of subcutaneous tissue dirofilariasis due to D. repens in Vietnam...
  94. ncbi [Ocular complications in patients with human immunodeficiency virus infection]
    Atsuko Uemura
    Department of Ophthalmology, International Medical Center of Japan 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Nihon Ganka Gakkai Zasshi 110:698-702. 2006
    ..To evaluate the recent clinical manifestations of ocular complications in patients with human immunodeficiency virus(HIV) infection...
  95. ncbi Nurse specialist treatment of eye emergencies: five year follow up study of quality and effectiveness
    John Cameron Buchan
    Department of Ophthalmology, St James s University Hospital, Beckett Street, Leeds LS9 7TF, United Kingdom
    Int Emerg Nurs 17:149-54. 2009
    ....
  96. ncbi Ocular melanosis in the Cairn Terrier: histopathological description of the condition, and immunohistological and ultrastructural characterization of the characteristic pigment-laden cells
    Simon M Petersen-Jones
    Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA
    Vet Ophthalmol 11:260-8. 2008
    ..Animals studied Forty-nine globes removed from 45 Cairn Terriers with ocular melanosis and three globes from control dogs were available for microscopic examination...
  97. ncbi [Ocular complications in patients infected with human immunodeficiency virus seen at the Acquired Immunodeficiency Syndrome Clinical Center]
    C Miyamoto
    Department of Ophthalmology, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan
    Nippon Ganka Gakkai Zasshi 105:483-7. 2001
    ..CONCLUSION: Cytomegalovirus retinopathy may occur in patients with a CD 4+ T-lymphocyte count of more than 200/mm3...
  98. ncbi Relationship between visual impairment and eye diseases and visual function in Andhra Pradesh
    Rishita Nutheti
    International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 114:1552-7. 2007
    To determine the impact of visual impairment and eye diseases on visual function in an older population of Andhra Pradesh in southern India.
  99. pmc MRI in ocular drug delivery
    S Kevin Li
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    NMR Biomed 21:941-56. 2008
    ..Different MR contrast agents and MRI techniques for ocular drug-delivery research are compared. Ocular drug-delivery studies using MRI are reviewed...
  100. ncbi The role of carotenoids in human health
    Elizabeth J Johnson
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Clin Care 5:56-65. 2002
    ..Until the efficacy and safety of taking supplements containing these nutrients can be determined, current dietary recommendations of diets high in fruits and vegetables are advised...
  101. ncbi Health effects of dust storms: subjective eye and respiratory system symptoms in inhabitants in Mongolia
    Haosheng Mu
    Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan
    J Environ Health 73:18-20. 2011
    ..The occurrence of lacrimation, an eye symptom, was higher among the desert area participants compared to those residing in the urban area. Results suggest that the occurrence of eye lacrimation is related to dust storms...

Research Grants70

  1. Recombinant T-cell Receptor Ligands for Treatment of Uveitis
    Grazyna Adamus; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Uveitis is a group of inflammatory eye diseases, often associated with an underlying autoimmune disease process...
  2. Planning a Clinical Trial on Low Vision Rehabilitation
    Cynthia Owsley; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Clinical Vision Research Unit at UAB
    Cynthia Owsley; Fiscal Year: 2006
    ..Furthermore, UAB has already established many community relations and research infrastructure contacts with these subpopulations that will immediately facilitate our research efforts. ..
  4. Improving the Quality of Diabetes Eye Care
    Paul Lee; Fiscal Year: 2006
    ..The insights from the study results should be applicable to other areas of diabetes care and health care in general. ..
  5. Retinal Microvascular Signs and CVD in Older Persons
    Tien Wong; Fiscal Year: 2005
    ..This may ultimately lead to improved identification, and preventive and therapeutic strategies for the most common causes of morbidity, disability and mortality affecting elderly people in the United States. ..
  6. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  7. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2008
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  8. Gene Therapy of Autosomal Recessive RP
    Simon Petersen Jones; Fiscal Year: 2006
    ..abstract_text> ..
  9. Trends in Use of Eye Care Services for Children
    Michael Ganz; Fiscal Year: 2005
    ..We will use data from the 1996 through the 2000 Medical Expenditure Panel Surveys (MEPS), supplemented with information from the 1995 though the 1999 National Health Interview Surveys (NHIS), to pursue these goals. ..
  10. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  11. PREVALENCE AND IMPACT OF GLAUCOMA AMONG THE VERY ELDERLY
    David Friedman; Fiscal Year: 2003
    ..Finally, the interactions between comorbidities (including cognitive deficits) and visual field loss will be explored. ..
  12. COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY
    Rohit Varma; Fiscal Year: 2003
    ....
  13. Localized modulation of RPE P-gp/MRP activity for back-of-the-eye drug delivery
    Soumyajit Majumdar; Fiscal Year: 2008
    ..Currently, direct intravitreal administration is the most effective mode of drug delivery for back-of-the-eye diseases. This route of administration, however, is associated with a number of risks such as retinal detachment, ..
  14. INTERVENTIONS FOR VISUAL LOSS IN NURSING HOME RESIDENTS
    Sheila West; Fiscal Year: 2002
    ..This trial will answer timely questions of the impact on the functional status of the most frail elderly of modest, potentially sustainable inputs into improving the appropriate utilization of eye care services. ..
  15. Complement inhibition in experimental autoimmune uveitis
    RUSSELL READ; Fiscal Year: 2006
    ..abstract_text> ..
  16. Development of Acoustic Tweezers
    K Shung; Fiscal Year: 2008
    ..abstract_text> ..
  17. TRIAL OF ANTIBIOTICS TO REDUCE RECURRENT TRICHIASIS
    Sheila West; Fiscal Year: 2005
    ..abstract_text> ..
  18. Symposium on Retinal/ Choroidal Angiogenesis
    John Penn; Fiscal Year: 2004
    ..J. Donald M. Gass, M.D. has agreed to write an introduction. In this application we request funds to support travel and registration costs of 20 young investigators and 2 keynote speakers. ..
  19. INHIBITION OF THE ANGIOGENIC RESPONSE
    Luisa Iruela Arispe; Fiscal Year: 2006
    ..abstract_text> ..
  20. Low-cost, portable, computer assisted imaging for diabe*
    Michael Abramoff; Fiscal Year: 2008
    ..Our overall aim is to validate and optimize a low-cost, high quality, patient friendly imaging system for the early diagnosis of diabetic retinopathy. ..
  21. Dietary Cancer Prevention in DNA Repair Deficient Mice
    Laura Niedernhofer; Fiscal Year: 2007
    ..Finally, these experiments will reveal if ERCC1-XPF hypomorphic mice are a useful model for screening anti-oxidants that may reduce cancer risk. [unreadable] [unreadable] [unreadable]..
  22. MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES
    ROBERT DESNICK; Fiscal Year: 2007
    ..It is anticipated that these trainees will continue the tradition of this program by becoming basic and/or clinical researchers in the field of human genetics and mental retardation. [unreadable] [unreadable]..
  23. CAROTENOIDS & AGE-RELATED EYE DISEASE IN WOMEN'S HEALTH
    Julie Mares; Fiscal Year: 2004
    ..also provide information needed about these relationships to conduct sound clinical trials that evaluate the influence of supplements containing these xanthophylls on shorter term progression of age-related eye diseases.
  24. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  25. QUALITY OF LIFE AND COST EFFECTIVENESS IN CMV RETINITIS
    John Kempen; Fiscal Year: 2002
    ..Subanalyses will assess what factors other than treatment strategy are associated with improved QOL and cost-effectiveness. ..
  26. Regulation of ACAID by lymphocytes with NK markers
    Joan Stein Streilein; Fiscal Year: 2010
    ..The results of these studies will raise the possibility of a cell based therapy to treat immune inflammatory diseases in the eye. ..
  27. In Vitro Method for Gut Absorption and Cytotoxicity
    FRANK BARILE; Fiscal Year: 2003
    ..abstract_text> ..
  28. A Multi-Center Study To Map Genes for Fuchs' Dystrophy
    Sudha Iyengar; Fiscal Year: 2009
    ..We anticipate that this study will lead to novel insights into the etiology of FECD and the biology of the corneal endothelium. ..
  29. TRANSGENIC ANAYLSIS OF RETINAL DEVELOPMENT
    JAMES FADOOL; Fiscal Year: 2003
    ..This feature of the enhancer trap is particularly significant because it should enable a fine-grained analysis of subtle abnormalities in retina that would otherwise escape detection. ..
  30. PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGE
    Harry Quigley; Fiscal Year: 2008
    ..Candidate molecules for genetic susceptibility to glaucoma are likely to be identified. ..
  31. Influence of eye pigmentation and diabetes on retinal drug delivery
    Uday B Kompella; Fiscal Year: 2010
    ..The findings of this study will be useful in developing drugs with enhanced transscleral delivery to the retina in order to treat diabetic retinopathy. ..
  32. Epidemiology of Venous Thromboembolism
    Robert Glynn; Fiscal Year: 2004
    ..The results of this work may lead to new strategies for VTE preventio. ..
  33. CULTURE SPECIFIC, PROBLEM BASED PATIENT SELF MANAGEMENT
    Robert Anderson; Fiscal Year: 2001
    ....
  34. MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGG
    WILLIAM JEFFERY; Fiscal Year: 2002
    ..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
  35. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Anne L Coleman; Fiscal Year: 2008
    ....
  36. Medication Use, Comorbidity and Outcomes in Aging populations
    Robert Glynn; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  37. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. Determinants of Venous Thromboembolism in Older People
    Robert J Glynn; Fiscal Year: 2010
    ..Results will help identify high-risk older people, and potentially modifiable behaviors that influence risk of ..
  39. Medication Use, Cormobidity and Outcomes in Aging Populations
    Robert J Glynn; Fiscal Year: 2010
    ..These studies are intended to advance methodologic strategies for evaluation of drug use and its effects in older people and to lay the foundation for interventions to improve prescribing in this population. ..
  40. PORPHYRIA AND HUMAN HEME BIOSYNTHESIS
    Robert J Desnick; Fiscal Year: 2010
    ..Viable CEP mice should permit studies of the disease pathophysiology and future therapeutic endeavors. ..
  41. Molecular Genetics of X-linked Cataracts
    Kristen Huang; Fiscal Year: 2007
    ..Identifying the XLCD gene would contribute to the our understanding of the molecular events involved in lens development. ..
  42. Spectrum of Autoimmune Gastrointestinal Dysmotility
    Vanda Lennon; Fiscal Year: 2009
    ..l.dysmotilities, and justify early consideration of immunomodulatory therapies. The proposed research also has high clinical relevance to cancer immunity. ..
  43. Yearly Mass Treatment C. Trachomatis: When Can We Stop?
    Sheila West; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  44. MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTURE
    Karina Davidson; Fiscal Year: 2008
    ..The ultimate goal will be to make our findings available to 3 target audiences: 1) the network of investigators at Columbia; 2) the behavioral medicine community; and 3) the general medical community. ..
  45. MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    Alan Verkman; Fiscal Year: 2008
    ..Methods will include fluorescence photobleaching recovery, energy transfer and ratio imaging. Also, specific water/solute transporting properties (Pd, c^)of the mammalian aquaporins will be measured. ..
  46. Tailored messages to increase eye examination behavior
    NANCY ELLISH; Fiscal Year: 2007
    ..This proposal addresses the need for research to assess tailored print communications to increase eye examination behavior in a minority population at increased risk for glaucoma. ..
  47. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  48. PATHOGENESIS OF RETINOPATHY OF PREMATURITY
    Jonathan Holmes; Fiscal Year: 2003
    ....
  49. Bypassing fluidics in proteomic screening
    PASCAL DESCHATELETS; Fiscal Year: 2005
    ..The success of this proposal will generate intelligence on millions of small molecule-protein interactions, generating unprecedented insight in the various gene/protein pathways and their role in disease. ..
  50. Virtual Reality Kinetopsic 3D Recognition in AD & aMCI
    Victoria Pelak; Fiscal Year: 2005
    ..abstract_text> ..
  51. Conditioned Placebo Effects & Treatment of Hypertension
    Thomas Pickering; Fiscal Year: 2005
    ..The demonstration of a conditioned placebo effect that produces a sustained reduction of BP could result in more economical treatment with fewer side effects. ..
  52. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
    ..abstract_text> ..
  53. Anti-angiogenic signaling molecules in retinal cells
    Nader Rahimi; Fiscal Year: 2004
    Angiogenesis, formation of new blood vessels from pre-existing vessels is a hallmark of many eye diseases such as age-related macular degeneration, proliferative diabetic retinopathy, retinopathy of prematurity and vascular glaucoma, ..
  54. Antigen Identification in Occult Chorioretinopathies
    Jeffrey Bennett; Fiscal Year: 2006
    ....
  55. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  56. Identification of Lens Development Genes
    Thomas Vihtelic; Fiscal Year: 2007
    ..The characterization of the molecular phenotype and determination of the underlying arl gene defect will lead to the identification of candidate genes in humans causing anterior segment dysgenesis and cataracts. ..
  57. DNA Interstrand Crosslinks, Cancer and Aging
    Laura Niedernhofer; Fiscal Year: 2007
    ..The technique will be applied to wild type and ICL repair-defective Ercc1-/- cells to determine what proteins assemble specifically at sites of lCL damage and in what chronological order. ..
  58. CLASSIFIERS FOR HIGH SPEED, HIGH-RESOLUTION CELL SORTING
    James Leary; Fiscal Year: 2001
    ..g. tumor) cells. Sort decisions need to make intelligent tradeoffs between yield and purity, and they should include costs of misclassification (Specific Aim 4). ..
  59. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..Information has been collected regarding cataract, other age-related eye diseases, medical conditions, medication usage; blood pressures, height and weight have been measured, as have several ..
  60. ULTRASONIC SCATTERING BY BIOLOGICAL TISSUES
    K Shung; Fiscal Year: 2001
    ..A better understanding of these relationships may lead to methods that can be used to estimate these parameters non-invasively. ..
  61. CLASSIFIERS FOR HIGH SPEED, HIGH-RESOLUTION CELL SORTING
    James Leary; Fiscal Year: 2003
    ..g. tumor) cells. Sort decisions need to make intelligent tradeoffs between yield and purity, and they should include costs of misclassification (Specific Aim 4). ..
  62. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..Specific aim 3: To develop and test gene vectors expressing inhibitors of angiogenesis (angiostatin, endostatin, PEDF) and test their ability to inhibit subretinal neovascularization in the mutant transgenic mouse. ..
  63. Embryonic Stem Cell Model of Polyglutamine Disease
    MATTHEW LORINCZ; Fiscal Year: 2007
    ..Once the pathologic mechanisms of mutant huntingtin are understood it will become possible to design rational therapeutics. ..
  64. A New Method for Retinal Imaging
    Alan Marmorstein; Fiscal Year: 2005
    ..One form of basal deposit, basal linear deposits, are more common in AMD eyes than age-matched controls. A positive outcome to this study would warrant future clinical trials. ..
  65. Bioencapsulated Factor IX for Oral Tolerance in Hemophilia B
    ROLAND HERZOG; Fiscal Year: 2008
    ..In future studies, the oral tolerance protocol will be further optimized and adapted to prevention of inhibitors to factor VIII in treatment of hemophilia A. [unreadable] [unreadable] [unreadable]..
  66. Ultrasound-Enhanced Delivery of Medications to the Eye
    Ronald Silverman; Fiscal Year: 2008
    ..We will visualize the distribution of the molecules within the sclera, choroid and retina to evaluate transport and characterize any tissue damage that might have occurred microscopically and by apoptosis assays. ..
  67. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  68. IMMUNOLOGICAL MECHANISM OF INFLAMMATION IN UVEITIS & EAE
    Grazyna Adamus; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract): Uveitis is a group of inflammatory eye diseases that may result from infections, malignancies, trauma, or incompletely understood processes that are presumably mediated by the body's immune ..