ischemic optic neuropathy

Summary

Summary: Ischemic injury to the optic nerve which usually affects the optic disk (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)

Top Publications

  1. ncbi Treatment of ischemic optic neuropathy
    Anthony C Arnold
    Jules Stein Eye Institue, Department of Ophthalmology, University of California, 100 Stein Plaza, Los Angeles, CA 90095 7005, USA
    Semin Ophthalmol 17:39-46. 2002
  2. ncbi Bilateral, nearly simultaneous anterior ischemic optic neuropathy complicated by diabetes and bilateral, small, crowded optic discs
    Junko Shibayama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan
    Jpn J Ophthalmol 49:235-8. 2005
  3. ncbi Non-arteritic anterior ischemic optic neuropathy (NA-AION) after intravitreal injection of bevacizumab (Avastin) for treatment of angoid streaks in pseudoxanthoma elasticum
    Martin Ganssauge
    Center of Ophthalmology, University of Tubingen, Schleichstrasse 12, 72076 Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1707-10. 2009
  4. ncbi Visual field abnormalities in nonarteritic anterior ischemic optic neuropathy: their pattern and prevalence at initial examination
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, The University of Iowa, Iowa City, USA
    Arch Ophthalmol 123:1554-62. 2005
  5. ncbi Ischemic optic neuropathy
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 1091, USA
    Prog Retin Eye Res 28:34-62. 2009
  6. pmc Progressive damage along the optic nerve following induction of crush injury or rodent anterior ischemic optic neuropathy in transgenic mice
    O Dratviman-Storobinsky
    The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Tel Aviv University, Petah Tiqwa, Israel
    Mol Vis 14:2171-9. 2008
  7. ncbi Optic disc evaluation by optical coherence tomography in nonarteritic anterior ischemic optic neuropathy
    Ines Contreras
    Ramon y Cajal Hospital, Madrid, Spain
    Invest Ophthalmol Vis Sci 48:4087-92. 2007
  8. ncbi Glucose-6-phosphate dehydrogenase (G6PD) deficiency in nonarteritic anterior ischemic optic neuropathy in a Sardinian population, Italy
    Antonio Pinna
    Institute of Ophthalmology, University of Sassari, Sassari, Italy
    Invest Ophthalmol Vis Sci 49:1328-32. 2008
  9. ncbi Anterior ischemic optic neuropathy in eyes with optic disc drusen
    Valerie Purvin
    Midwest Eye Institute, Indianapolis, IN 46280, USA
    Arch Ophthalmol 122:48-53. 2004
  10. ncbi Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation
    Charles J Glueck
    Cholesterol Center, Cincinnati, OH 45229, USA
    J Lab Clin Med 143:184-92. 2004

Detail Information

Publications217 found, 100 shown here

  1. ncbi Treatment of ischemic optic neuropathy
    Anthony C Arnold
    Jules Stein Eye Institue, Department of Ophthalmology, University of California, 100 Stein Plaza, Los Angeles, CA 90095 7005, USA
    Semin Ophthalmol 17:39-46. 2002
    ..Neuroprotective strategies are under intense investigation for optic neuropathies including NAION, and clinical trials in humans are in progress. Optic nerve regeneration studies are ongoing in animals. Prophylaxis in NAION is unproven...
  2. ncbi Bilateral, nearly simultaneous anterior ischemic optic neuropathy complicated by diabetes and bilateral, small, crowded optic discs
    Junko Shibayama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan
    Jpn J Ophthalmol 49:235-8. 2005
    Bilateral simultaneous anterior ischemic optic neuropathy (AION) is uncommon. We report a case of bilateral and nearly simultaneously occurring AION.
  3. ncbi Non-arteritic anterior ischemic optic neuropathy (NA-AION) after intravitreal injection of bevacizumab (Avastin) for treatment of angoid streaks in pseudoxanthoma elasticum
    Martin Ganssauge
    Center of Ophthalmology, University of Tubingen, Schleichstrasse 12, 72076 Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1707-10. 2009
    To report a case of nonarteritic anterior ischemic optic neuropathy (NA-AION) following intravitreal injection of bevacizumab (Avastin).
  4. ncbi Visual field abnormalities in nonarteritic anterior ischemic optic neuropathy: their pattern and prevalence at initial examination
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, The University of Iowa, Iowa City, USA
    Arch Ophthalmol 123:1554-62. 2005
    To evaluate the pattern of various types of visual field defects and their prevalence at initial examination of nonarteritic anterior ischemic optic neuropathy (NA-AION).
  5. ncbi Ischemic optic neuropathy
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 1091, USA
    Prog Retin Eye Res 28:34-62. 2009
    b>Ischemic optic neuropathy is one of the major causes of blindness or seriously impaired vision, yet there is disagreement as to its pathogenesis, clinical features and especially its management...
  6. pmc Progressive damage along the optic nerve following induction of crush injury or rodent anterior ischemic optic neuropathy in transgenic mice
    O Dratviman-Storobinsky
    The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Tel Aviv University, Petah Tiqwa, Israel
    Mol Vis 14:2171-9. 2008
    ..To characterize the histological changes that occur in response to induction of ischemic or mechanical optic nerve damage in transgenic mice...
  7. ncbi Optic disc evaluation by optical coherence tomography in nonarteritic anterior ischemic optic neuropathy
    Ines Contreras
    Ramon y Cajal Hospital, Madrid, Spain
    Invest Ophthalmol Vis Sci 48:4087-92. 2007
    To describe the characteristics of the optic nerve head (ONH) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and compare them with control subjects by using optical coherence tomography (OCT).
  8. ncbi Glucose-6-phosphate dehydrogenase (G6PD) deficiency in nonarteritic anterior ischemic optic neuropathy in a Sardinian population, Italy
    Antonio Pinna
    Institute of Ophthalmology, University of Sassari, Sassari, Italy
    Invest Ophthalmol Vis Sci 49:1328-32. 2008
    ..The purpose of this study was to assess the frequency of G6PD deficiency in Sardinian patients with nonarteritic anterior ischemic optic neuropathy (NAION) and ascertain whether G6PD deficiency may offer protection against NAION.
  9. ncbi Anterior ischemic optic neuropathy in eyes with optic disc drusen
    Valerie Purvin
    Midwest Eye Institute, Indianapolis, IN 46280, USA
    Arch Ophthalmol 122:48-53. 2004
    There have been anecdotal reports of anterior ischemic optic neuropathy (AION) occurring in eyes with optic disc drusen (ODD), but the clinical features of this condition have not been well characterized.
  10. ncbi Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation
    Charles J Glueck
    Cholesterol Center, Cincinnati, OH 45229, USA
    J Lab Clin Med 143:184-92. 2004
    The association between nonarteritic anterior ischemic optic neuropathy (NAION) and coagulation disorders was prospectively assessed at least 3 months after the occurrence of ocular vascular events in 12 white patients in an outpatient ..
  11. ncbi Evaluation of traditional and emerging cardiovascular risk factors in patients with non-arteritic anterior ischemic optic neuropathy: a case-control study
    Barbara Giambene
    Eye Clinic, University of Florence, Viale Morgagni, 85 50134, Florence, Italy
    Graefes Arch Clin Exp Ophthalmol 247:693-7. 2009
    Non-arteritic anterior ischemic optic neuropathy (NAION) is a multifactorial disease that is caused by an infarction of the vessels that supply the optic nerve head...
  12. ncbi Nonarteritic anterior ischemic optic neuropathy: refractive error and its relationship to cup/disc ratio
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Ophthalmology 115:2275-81. 2008
    To investigate refractive error in eyes with nonarteritic anterior ischemic optic neuropathy (NA-AION) and its relationship to cup/disc (C/D) ratio.
  13. ncbi Indocyanine green and fluorescein angiography in nonarteritic anterior ischemic optic neuropathy
    Sibel Oto
    Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
    Retina 22:187-91. 2002
    To assess the value of indocyanine green angiography (ICGA) for demonstrating choroidal vascular abnormalities in patients with nonarteritic anterior ischemic optic neuropathy (NAION).
  14. ncbi Incidence of nonarteritic anterior ischemic optic neuropathy in adult Chinese: the Beijing Eye Study
    L Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Eur J Ophthalmol 17:459-60. 2007
    To determine the incidence of optic nerve damage due to nonarteritic anterior ischemic optic neuropathy (NAION) in the adult Chinese population.
  15. ncbi Postoperative ischemic optic neuropathy
    Lorri A Lee
    Departmentof Anesthesiology and Pain Medicine, University of Washington, Box 356540BB, 1469 Health Sciences Building, 1959 N E Pacific Street, Seattle, WA 98195 6540, USA
    Spine (Phila Pa 1976) 35:S105-16. 2010
    ..Systematic literature review...
  16. ncbi Treatment of nonarteritic anterior ischemic optic neuropathy with intravitreal bevacizumab
    Jeffrey L Bennett
    J Neuroophthalmol 27:238-40. 2007
  17. ncbi Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion
    P Pianka
    Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Ophthalmology 107:1588-92. 2000
    This study aimed to determine the prevalence of hyperhomocystinemia among patients with nonarteritic anterior ischemic optic neuropathy (NAION), central retinal artery occlusion (CRAO), or central retinal vein occlusion (CRVO).
  18. ncbi Bilateral posterior ischemic optic neuropathy after lumbar spine surgery
    Marjorie A Murphy
    Department of Ophthalmology, APC 7, Rhode Island Hospital, Brown Medical School, 593 Eddy Street, Providence, RI 02903, USA
    Ophthalmology 110:1454-7. 2003
    To report a case of bilateral posterior ischemic optic neuropathy (PION) in a healthy young patient after lumbar spine surgery which was initially diagnosed as functional visual loss.
  19. ncbi Efficacy and tolerability of 0.2% brimonidine tartrate for the treatment of acute non-arteritic anterior ischemic optic neuropathy (NAION): a 3-month, double-masked, randomised, placebo-controlled trial
    Barbara Wilhelm
    Steinbeis Transfer Centre for Biomedical Optics and Function Testing Tübingen, Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 244:551-8. 2006
    ..2% brimonidine tartrate could improve the outcome of patients with non-arteritic anterior ischemic optic neuropathy (NAION)...
  20. ncbi Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography
    Ines Contreras
    Ophthalmology Department, Ramon y Cajal Hospital, Madrid, Spain
    Ophthalmology 114:2338-44. 2007
    To study the characteristics of nonarteritic anterior ischemic optic neuropathy (NAION) as measured with optical coherence tomography (OCT) at diagnosis and during the first year after the episode.
  21. ncbi Use of magnetic resonance imaging to differentiate optic neuritis and nonarteritic anterior ischemic optic neuropathy
    Joseph F Rizzo
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 109:1679-84. 2002
    To determine if magnetic resonance imaging (MRI) of the optic nerves obtained during the acute phase can distinguish patients with optic neuritis (ON) from those with nonarteritic anterior ischemic optic neuropathy (NAION).
  22. ncbi Intraorbital optic nerve signal hyperintensity on magnetic resonance imaging sequences in perioperative hypotensive ischemic optic neuropathy
    Valerie Purvin
    Neuro ophthalmology Section, Midwest Eye Institute and the Department of Ophthalmology, Indiana University Medical Center, Indianapolis, Indiana 46280, USA
    J Neuroophthalmol 25:202-4. 2005
    A 61-year-old man experienced severe bilateral posterior ischemic optic neuropathy after cardiac bypass surgery...
  23. ncbi Bilateral anterior ischemic optic neuropathy after liposuction
    Rod Foroozan
    Neuro Ophthalmology Service RF, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin NC 205, Houston, TX 77030, USA
    J Neuroophthalmol 24:211-3. 2004
    A 30-year-old woman had bilateral anterior ischemic optic neuropathy after undergoing large-volume liposuction...
  24. ncbi Perioperative risk factors for posterior ischemic optic neuropathy
    Stephan Dunker
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    J Am Coll Surg 194:705-10. 2002
    Infarction of the optic nerve posterior to the lamina cribrosa, called posterior ischemic optic neuropathy (PION), is a condition that can result in profound bilateral blindness...
  25. ncbi Nonarteritic anterior ischemic optic neuropathy in patients with sleep apnea while being treated with continuous positive airway pressure
    Raed Behbehani
    Neuroophthalmology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Ophthalmol 139:518-21. 2005
    To report three cases of nonarteritic anterior ischemic optic neuropathy (NAION) that occurred in patients with sleep apnea syndrome (SAS) while being treated with continuous positive airway pressure (CPAP).
  26. ncbi Recurrent visual field defect and ischemic optic neuropathy associated with tadalafil rechallenge
    Kathryn Bollinger
    Cole Eye Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Arch Ophthalmol 123:400-1. 2005
  27. ncbi Ipsilateral recurrence of nonarteritic anterior ischemic optic neuropathy
    S S Hayreh
    Department of Ophthalmology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Ophthalmol 132:734-42. 2001
    To report the prevalence of recurrence of nonarteritic anterior ischemic optic neuropathy (NA-AION) in the same eye and possible contributing risk factors.
  28. pmc Does topical brimonidine tartrate help NAION?
    H E Fazzone
    Br J Ophthalmol 87:1193-4. 2003
  29. ncbi Optic nerve head circulation in nonarteritic anterior ischemic optic neuropathy and optic neuritis
    Nathalie J Collignon-Robe
    Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 111:1663-72. 2004
    To quantify optic nerve head circulatory abnormalities in patients with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) or optic neuritis (ON), and to assess the potential of such measurements to differentiate NAION ..
  30. ncbi Posner-Schlossman syndrome and nonarteritic anterior ischemic optic neuropathy
    Inci Irak
    Department of Ophthalmology and Visual Sciences and the John A Moran Eye Center, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    J Neuroophthalmol 23:264-7. 2003
    ..represents a concurrence of glaucomatocyclitic crisis (Posner-Schlossman syndrome, PSS) and nonarteritic ischemic optic neuropathy (NAION)...
  31. ncbi Chlamydia pneumoniae seropositivity and the risk of nonarteritic ischemic optic neuropathy
    Martin Weger
    Department of Ophthalmology, Karl Franzens University, Auenbruggerplatz 4, 8036 Graz, Austria
    Ophthalmology 109:749-52. 2002
    To determine whether IgG antibodies to Chlamydia pneumoniae are associated with nonarteritic ischemic optic neuropathy (NAION).
  32. ncbi Nonarteritic anterior ischemic optic neuropathy associated with acute glaucoma secondary to Posner-Schlossman syndrome
    Rubin Kim
    Kresge Eye Institute, 4717 St Antoine, Detroit, MI 48201, USA
    Arch Ophthalmol 121:127-8. 2003
  33. ncbi Posterior ischemic optic neuropathy after minimally invasive prostatectomy
    Eric D Weber
    Ophthalmology Service, Walter Reed Army Medical Center, Washington, DC, USA
    J Neuroophthalmol 27:285-7. 2007
    Two patients developed postoperative ischemic optic neuropathy (ION) after laparoscopic radical prostatectomy. One operation was robotically assisted; the other was performed with the conventional laparoscopic technique...
  34. ncbi Levodopa may improve vision loss in recent-onset, nonarteritic anterior ischemic optic neuropathy
    L N Johnson
    Neuro Ophthalmology Unit, Mason Eye Institute, University of Missouri Columbia, 65212, USA
    Ophthalmology 107:521-6. 2000
    To study the effect of levodopa in improving visual function in patients treated within 45 days of onset of nonarteritic anterior ischemic optic neuropathy (NAION).
  35. ncbi [Arterial hypotension-risk factor in nonarteritic anterior ischemic optic neuropathy]
    Adriana Bulboaca
    Spitalul Clinic de Recuperare Cabinet Oftalmologie, U M F Cluj
    Oftalmologia 53:52-5. 2002
    To determine whether a decrease a arterial blood pressure may be a risk factor in occurrence of non-arteritic anterior ischemic optic neuropathy (NAION).
  36. ncbi Subretinal fluid from anterior ischemic optic neuropathy demonstrated by optical coherence tomography
    Thomas R Hedges
    New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Arch Ophthalmol 126:812-5. 2008
    To demonstrate the development of subfoveal fluid associated with optic disc swelling from nonarteritic anterior ischemic optic neuropathy.
  37. ncbi Ischemic optic neuropathy associated with internal carotid artery dissection
    V Biousse
    Department of Neurology, Hopital Lariboisiere, Paris, France
    Arch Neurol 55:715-9. 1998
    b>Ischemic optic neuropathy (ION) is an infarction of the anterior or, less frequently, posterior part of the optic nerve, usually due to a disease of small arteries supplying the optic nerve...
  38. pmc Recurrent herpes labialis as a potential risk factor for nonarteritic anterior ischemic optic neuropathy
    L N Johnson
    Neuro Ophthalmology Unit, Mason Institute of Ophthalmology, University of Missouri Columbia 65212, USA
    J Natl Med Assoc 88:369-73. 1996
    ..recurrent herpes labialis posed an independent risk factor for the development of nonarteritic anterior ischemic optic neuropathy among individuals with small optic nerve cup:disk ratio...
  39. ncbi Optic disc and peripapillary morphology in unilateral nonarteritic anterior ischemic optic neuropathy and age- and refraction-matched normals
    Hitomi Saito
    Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Ophthalmology 115:1585-90. 2008
    ..fiber layer (RNFL) thickness between the unaffected eyes of patients with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and their affected eyes and the eyes of age- and refraction-matched normal control subjects.
  40. pmc Rodent anterior ischemic optic neuropathy (rAION) induces regional retinal ganglion cell apoptosis with a unique temporal pattern
    Bernard J Slater
    Department of Ophthalmology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 49:3671-6. 2008
    Nonarteritic anterior ischemic optic neuropathy (NAION) results in optic nerve damage with retinal ganglion cell (RGC) loss...
  41. ncbi Vitrectomy and release of presumed epipapillary vitreous traction for treatment of nonarteritic anterior ischemic optic neuropathy associated with partial posterior vitreous detachment
    Mehdi Modarres
    Department of Ophthalmology, Rasool Akram Medical Center, Tehran, Iran
    Ophthalmology 114:340-4. 2007
    To study the results of vitrectomy and release of epipapillary vitreous adhesions for the treatment of nonarteritic anterior ischemic optic neuropathy (NAION) associated with partial posterior vitreous detachment (PVD).
  42. pmc Optic nerve infarction and post-ischemic inflammation in the rodent model of anterior ischemic optic neuropathy (rAION)
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Brain Res 1264:67-75. 2009
    Nonarteritic anterior ischemic optic neuropathy (NAION) results from isolated anterior optic nerve (ON)-axonal ischemia near the retina-optic nerve junction...
  43. ncbi Interaction of heritable and estrogen-induced thrombophilia: possible etiologies for ischemic optic neuropathy and ischemic stroke
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Thromb Haemost 85:256-9. 2001
    ..how thrombophilic exogenous estrogens interacted with heritable thrombophilias leading to non-arteritic ischemic optic neuropathy (NAION) and ischemic stroke...
  44. ncbi Anterior ischemic optic neuropathy associated with Vogt-Koyanagi-Harada disease
    Kumiko Nakao
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Graefes Arch Clin Exp Ophthalmol 247:1417-25. 2009
    ..This reports report presents recent findings regarding unusual patients with visual field defects from optic disc involvement, thus suggesting the presence of anterior ischemic optic neuropathy (AION) in the acute phase of VKH.
  45. ncbi Suspected simultaneous bilateral anterior ischemic optic neuropathy in a patient with Behçet's disease
    Yasuyuki Yamauchi
    Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
    Ocul Immunol Inflamm 13:317-25. 2005
    To report a 47-year-old Japanese woman with a one-year history of Behçet's disease who complained of sudden bilateral visual loss with concurrent anterior ischemic optic neuropathy (AION).
  46. ncbi Giant cell (Temporal) arteritis with anterior ischemic optic neuropathy: a biopsy-proven case in Taiwan
    Cheng Kuo Cheng
    Department of Ophthalmology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 109:550-4. 2010
    Giant cell arteritis with arteritic anterior ischemic optic neuropathy has rarely been diagnosed in Taiwan...
  47. doi Endothelin-1 in ischemic optic neuropathy
    Tsutomu Sakai
    Ophthalmology 115:1262. 2008
  48. ncbi The morphology of an infarct in nonarteritic anterior ischemic optic neuropathy
    Rachel A Tesser
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Ophthalmology 110:2031-5. 2003
    The mechanism by which nonarteritic anterior ischemic optic neuropathy (NAION) causes an infarct in the optic nerve is controversial...
  49. ncbi LDL-apheresis accelerates the recovery of nonarteritic acute anterior ischemic optic neuropathy
    Alfonso Ramunni
    Division of Nephrology, Department of Internal and Public Medicine, Universit of Bari, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Ther Apher Dial 9:53-8. 2005
    Nonarteritic acute anterior ischemic optic neuropathy (NAION) is a disabling disease which impairs visual function...
  50. ncbi Comparison of optic nerve head topography findings in eyes with non-arteritic anterior ischemic optic neuropathy and eyes with glaucoma
    Josepha Horowitz
    Department of Ophthalmology, Carmel Medical Center, affiliated to the Bruce Rappaport Medical School, The Technion, Michal 7 St, Haifa, Israel
    Graefes Arch Clin Exp Ophthalmol 248:845-51. 2010
    To compare the peripapillary retinal nerve fiber layer (RNFL) thickness in eyes affected by non-arteritic ischemic optic neuropathy (NAION) or glaucoma as determined by optical coherence tomography (OCT).
  51. ncbi Interferon-alpha-associated bilateral simultaneous ischemic optic neuropathy
    Yoav Vardizer
    Department of Ophthalmology, Tel Aviv Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    J Neuroophthalmol 23:256-9. 2003
    ..thrombocytosis and one with chronic hepatitis C infection who developed bilateral simultaneous anterior ischemic optic neuropathy within 3 months of starting treatment with interferon-alpha...
  52. ncbi An occult case of giant cell arteritis presenting with combined anterior ischemic optic neuropathy and cilioretinal artery occlusion
    John M Galasso
    Department of Ophthalmology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Semin Ophthalmol 19:75-7. 2004
    ..Arteritic anterior ischemic optic neuropathy typically results from thrombotic occlusion of the short posterior ciliary arteries...
  53. ncbi LDL-apheresis in acute anterior ischemic optic neuropathy
    A Ramunni
    Division of Nephrology, Department of Internal and Public Medicine, University of Bari, Bari, Italy
    Int J Artif Organs 27:337-41. 2004
    Acute anterior ischemic optic neuropathy (AION) is a disabling disease which impairs visual function. Standard treatment is unable to affect the outcome and the visual damage persists...
  54. ncbi Posterior ischemic optic neuropathy after hemodialysis
    Lawrence M Buono
    Neuro Ophthalmology Service, Wills Eye Hospital, Thomas Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Ophthalmology 110:1216-8. 2003
    To report a case of visual loss from posterior ischemic optic neuropathy (PION) after hemodialysis.
  55. ncbi Increased plasma and optic nerve levels of IL-6, TNF-alpha, and MIP-2 following induction of ischemic optic neuropathy in mice
    Bat Chen R Avraham
    The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Petach Tikva, Israel
    Curr Eye Res 33:395-401. 2008
    To investigate levels of proinflammatory cytokines in a mouse model of anterior ischemic optic neuropathy (rAION).
  56. ncbi Intravitreal triamcinolone or bevacizumab for nonarteritic anterior ischemic optic neuropathy: do they merit further study?
    Shalom E Kelman
    J Neuroophthalmol 27:161-3. 2007
  57. ncbi Sudden visual loss due to posterior ischemic optic neuropathy following craniotomy for a ruptured intracranial aneurysm
    Kishor A Choudhari
    Department of Neurosurgery, Royal Victoria Hospital, Regional Neurosciences Unit, Belfast BT12 6BA, United Kingdom
    Neurol India 55:163-5. 2007
    ..Posterior ischemic optic neuropathy caused by external pressure on the ipsilateral eye, its differentials and subsequent medico-legal ..
  58. ncbi Is the efficacy of LDL apheresis in ischemic optic neuropathy linked to a reduction in endothelial activation markers?
    A Ramunni
    Division of Nephrology, Department of Internal and Public Medicine, University of Bari, Bari, Italy
    Blood Purif 24:405-12. 2006
    ..of the optic microcirculation is considered to be the main pathogenetic mechanism in nonarteritic ischemic optic neuropathy. The aim of the present work was to assess whether a clinical improvement is correlated with a reduction ..
  59. ncbi Selective thrombophilia screening of patients with nonarteritic anterior ischemic optic neuropathy
    Claudia Kuhli-Hattenbach
    Klinik fur Augenheilkunde, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Graefes Arch Clin Exp Ophthalmol 247:485-90. 2009
    ..whether there is a relationship between thrombophilic disorders and the development of nonarteritic ischemic optic neuropathy (NAION) remains controversial...
  60. ncbi Anterior ischemic optic neuropathy after emergency caesarean section under epidural anesthesia
    M Gupta
    Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, England
    Acta Anaesthesiol Scand 46:751-2. 2002
    We report a case of non arteritic anterior ischemic optic neuropathy following caesarean delivery in a patient who had epidural analgesia. There was doubt as to whether it was subdural...
  61. pmc Ischemic optic neuropathy following spine surgery
    Vivien T G Ho
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosurg Anesthesiol 17:38-44. 2005
    ..The most common cause of POVL is ischemic optic neuropathy (ION)...
  62. pmc Sildenafil citrate use and the incidence of nonarteritic anterior ischemic optic neuropathy
    L Gorkin
    World Wide Outcomes Research, Global Epidemiology, US Medical Research, Pfizer Inc, NY, USA
    Int J Clin Pract 60:500-3. 2006
    Nonarteritic anterior ischemic optic neuropathy (NAION) has been reported rarely in men after taking sildenafil or other phosphodiesterase 5 inhibitors for erectile dysfunction (ED)...
  63. ncbi Sequential anterior ischemic optic neuropathy and central retinal artery and vein occlusion after ranibizumab for diabetic macular edema
    Maurizio Battaglia Parodi
    Department of Ophthalmology, University Vita Salute, Scientific Institute San Raffaele, Via Olgettina 60, Milan, Italy
    Eur J Ophthalmol 20:1076-8. 2010
    To describe a rare adverse event characterized by anterior ischemic optic neuropathy (AION) associated with central retinal artery occlusion (CRAO) followed by central retinal vein occlusion (CRVO) secondary to treatment with ..
  64. ncbi Thrombophilic risk factors in the pathogenesis of non-arteritic anterior ischemic optic neuropathy patients
    Taxiarchis Felekis
    University Eye Clinic of Ioannina, Kosti Palama 1, Anatoli, Ioannina, 45500, Greece
    Graefes Arch Clin Exp Ophthalmol 248:877-84. 2010
    Non-arteritic anterior ischemic optic neuropathy (N-AION) is caused by acute ischemic infarction of the optic nerve head, supplied by the posterior ciliary arteries...
  65. ncbi Clinical profile of patients with nonarteritic anterior ischemic optic neuropathy presented to a referral center from 2003 to 2008
    Khalil Ghasemi Falavarjani
    Eye Research Center and Eye Department, Rassoul e Akram Hospital, Iran University of Medical Sciences, Tehran 14455 364, Iran
    Arch Iran Med 12:472-7. 2009
    We conducted this study to report the demographics and clinical profile of patients with nonarteritic anterior ischemic optic neuropathy referred to a referral neuro-ophthalmology center in Iran.
  66. doi Intravitreal triamcinolone for nonarteritic anterior ischemic optic neuropathy
    Sohan Singh Hayreh
    J Neuroophthalmol 28:77-8; author reply 78-9. 2008
  67. ncbi Erectile dysfunction drugs and nonarteritic anterior ischemic optic neuropathy
    Andrew G Lee
    Am J Ophthalmol 140:707-8. 2005
  68. pmc Computerized expert system for evaluation of automated visual fields from the Ischemic Optic Neuropathy Decompression Trial: methods, baseline fields, and six-month longitudinal follow-up
    Steven E Feldon
    Department of Ophthalmology, Center for Visual Science and the Eye Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Trans Am Ophthalmol Soc 102:269-303. 2004
    To validate a computerized expert system evaluating visual fields in a prospective clinical trial, the Ischemic Optic Neuropathy Decompression Trial (IONDT)...
  69. ncbi Visual function in anterior ischemic optic neuropathy: effect of Vision Restoration Therapy--a pilot study
    Cecilia S Jung
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA
    J Neurol Sci 268:145-9. 2008
    To evaluate the effects of Vision Restoration Therapy (VRT) on the visual function of patients with anterior ischemic optic neuropathy.
  70. ncbi Familial non-arteritic anterior ischemic optic neuropathy
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1091, USA
    Graefes Arch Clin Exp Ophthalmol 246:1295-305. 2008
    Primary objective was to investigate clinical characteristics of nonarteritic anterior ischemic optic neuropathy (NA-AION) in three families; secondarily, to test these families for a previously detected mitochondrial mutation in a ..
  71. ncbi Optic disc morphology after arteritic anterior ischemic optic neuropathy
    S S Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Ophthalmology 108:1586-94. 2001
    ..the appearance of the nerve head in patients after giant cell arteritis-induced arteritic anterior ischemic optic neuropathy (A-AION). DESIGN: Noncomparative clinical case series...
  72. ncbi The fellow eye in NAION: report from the ischemic optic neuropathy decompression trial follow-up study
    Nancy J Newman
    Department of Ophthalmology, Neurology, and Neurological Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Ophthalmol 134:317-28. 2002
    To examine the prevalence and incidence of second eye nonarteritic anterior ischemic optic neuropathy (NAION) and associated patient characteristics in patients enrolled in the Ischemic Optic Neuropathy Decompression Trial (IONDT) Follow-..
  73. ncbi Retinal nerve fiber layer thickness in nonarteritic anterior ischemic optic neuropathy: OCT characterization of the acute and resolving phases
    Costantino Bellusci
    Centro Salus, via Saffi 4 H, 40131, Bologna, Italy
    Graefes Arch Clin Exp Ophthalmol 246:641-7. 2008
    To evaluate longitudinal changes in retinal nerve fiber layer (RNFL) thickness in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography (OCT).
  74. ncbi Effect of transcorneal electrical stimulation in patients with nonarteritic ischemic optic neuropathy or traumatic optic neuropathy
    Takashi Fujikado
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Jpn J Ophthalmol 50:266-73. 2006
    To determine whether transcorneal electrical stimulation (TES) can improve the visual function of patients with nonarteritic ischemic optic neuropathy (NAION) or traumatic optic neuropathy (TON).
  75. ncbi Anterior ischemic optic neuropathy in patients younger than 50 years
    Pisit Preechawat
    Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand
    Am J Ophthalmol 144:953-60. 2007
    To characterize anterior ischemic optic neuropathy (AION) in patients younger than 50 years.
  76. ncbi Optic disc topography and peripapillary retinal nerve fiber layer thickness in nonarteritic ischemic optic neuropathy and open-angle glaucoma
    Hitomi Saito
    Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Ophthalmology 113:1340-4. 2006
    ..results of scanning laser tomography and scanning laser polarimetry (SLP) and the correlations with visual field damage (VFD) in eyes with nonarteritic ischemic optic neuropathy (n-AION) compared with eyes with open-angle glaucoma (OAG).
  77. ncbi Diffusion MR imaging in a case of acute ischemic optic neuropathy
    L S Al-Shafai
    Department of Radiology, National Guard Hospital, Al Ahsa, Saudi Arabia
    AJNR Am J Neuroradiol 27:255-7. 2006
    ..is to show the diagnostic potential of diffusion-weighted MR imaging in establishing the presence of ischemic optic neuropathy (ION)...
  78. pmc Anterior ischaemic optic neuropathy after rotator cuff surgery
    M E Gilbert
    Br J Ophthalmol 90:248-9. 2006
  79. ncbi Anterior ischemic optic neuropathy associated with rickettsia conorii infection
    Moncef Khairallah
    Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia
    J Neuroophthalmol 25:212-4. 2005
    A 43-year-old man with fever, headache, and skin rash developed unilateral acute anterior ischemic optic neuropathy. The indirect immunofluorescence test was positive for Rickettsia conorii...
  80. ncbi Nonarteritic ischemic optic neuropathy developing soon after use of sildenafil (viagra): a report of seven new cases
    Howard D Pomeranz
    Department of Ophthalmology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neuroophthalmol 25:9-13. 2005
    Seven patients, aged between 50 and 69 years, had typical features of nonarteritic anterior ischemic optic neuropathy (NAION) within 36 hours after ingestion of sildenafil citrate (Viagra) for erectile dysfunction...
  81. ncbi Optic disc edema in non-arteritic anterior ischemic optic neuropathy
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, IA 52242 1091, USA
    Graefes Arch Clin Exp Ophthalmol 245:1107-21. 2007
    ..factors that influence it, and evolutionary pattern of optic disc edema (ODE) in non-arteritic anterior ischemic optic neuropathy (NA-AION)...
  82. doi Bilateral posterior ischemic optic neuropathy associated with use of sildenafil
    Daniel Hsien Wen Su
    J Neuroophthalmol 28:75. 2008
  83. ncbi The prevalence of cupping in end-stage arteritic and nonarteritic anterior ischemic optic neuropathy
    H V Danesh-Meyer
    Discipline of Ophthalmology, University of Auckland, Auckland, New Zealand
    Ophthalmology 108:593-8. 2001
    OBJECTIVE: To evaluate the prevalence of cupping in arteritic anterior ischemic optic neuropathy (AAION) and nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN: Retrospective, observational case series...
  84. ncbi Nonarteritic anterior ischemic optic neuropathy: clinical characteristics in diabetic patients versus nondiabetic patients
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Ophthalmology 115:1818-25. 2008
    To investigate various aspects of nonarteritic anterior ischemic optic neuropathy (NA-AION) in patients with diabetes mellitus and to compare them with those in patients without diabetes mellitus.
  85. ncbi Non-arteritic anterior ischemic optic neuropathy, PDE-5 inhibitors, and amiodarone: may there be a sex hormone effect for the eye?
    A Verit
    Med Hypotheses 69:470-1. 2007
  86. ncbi Trombophilic screening for nonarteritic anterior ischemic optic neuropathy
    Valeria Nagy
    Department of Ophthalmology, University of Debrecen, Medical and Health Science Center, 4012 Debrecen, Hungary
    Graefes Arch Clin Exp Ophthalmol 244:3-8. 2006
    Nonarteritic anterior ischemic optic neuropathy (NAION) is an ischemic infarction of the optic nerve head, frequently leading to sudden, mostly irreversible loss of vision...
  87. ncbi Reversal of nonarteritic anterior ischemic optic neuropathy associated with coexisting primary antiphospholipid syndrome and Factor V Leiden mutation
    S Srinivasan
    Department of Ophthalmology, Monklands Hospital, Lanarkshire Acute Hospitals NHS Trust, Airdrie, Scotland, UK
    Am J Ophthalmol 131:671-3. 2001
    To report nonarteric anterior ischemic optic neuropathy (NAION) as an ocular manifestation in a woman with combined primary antiphospholipid syndrome and Factor V Leiden (FVL) mutation.
  88. ncbi Functional and cellular responses in a novel rodent model of anterior ischemic optic neuropathy
    Steven L Bernstein
    Department of Ophthalmology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Invest Ophthalmol Vis Sci 44:4153-62. 2003
    Anterior ischemic optic neuropathy (AION) is caused by sudden loss of vascular supply to retinal ganglion cell (RGC) axons in the anterior portion of the optic nerve and is a major cause of optic nerve dysfunction...
  89. ncbi Clinical spectrum of posterior ischemic optic neuropathy
    S R Sadda
    Neuro-Ophthalmology Unit, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Ophthalmol 132:743-50. 2001
    PURPOSE: To describe the systemic and visual characteristics and prognosis in patients with posterior ischemic optic neuropathy (PION). DESIGN: Observational case series. METHODS: Retrospective chart review in a multicenter setting...
  90. ncbi Ophthalmic complications after spinal surgery
    W R Stevens
    Department of Orthopaedic Surgery, University of California at San Francisco, USA
    Spine (Phila Pa 1976) 22:1319-24. 1997
    ..Because ophthalmic complications in spinal surgery may be reversed with prompt recognition and intervention, it is important for clinicians to be aware of their possible occurrence...
  91. ncbi Anterior ischemic optic neuropathy associated with viagra
    A V Cunningham
    Department of Surgery, Scott and White Memorial Hospital, Temple, Texas, USA
    J Neuroophthalmol 21:22-5. 2001
    ..1 cup-to-disc ratio and a prominent disc hemorrhage. Anterior ischemic optic neuropathy (AION) is associated with acute episodes of hypotension in patients with structurally crowded discs...
  92. ncbi Visual field defects in optic neuritis and anterior ischemic optic neuropathy: distinctive features
    J Gerling
    Abteilung Neuroophthalmologie und Schielbehandlung, Universitats Augenklinik, Freiburg, Germany
    Graefes Arch Clin Exp Ophthalmol 236:188-92. 1998
    We analyzed the value of visual-field defects in the differential diagnosis of optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (AION).
  93. ncbi Nonarteritic anterior ischemic optic neuropathy: time of onset of visual loss
    S S Hayreh
    Department of Ophthalmology, College of Medicine, University of Iowa, Iowa City 52242 1091, USA
    Am J Ophthalmol 124:641-7. 1997
    To study time of day and seasonal variation of onset of visual loss in nonarteritic anterior ischemic optic neuropathy (AION).
  94. pmc Treatment of nonarteritic anterior ischemic optic neuropathy
    Edward J Atkins
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA
    Surv Ophthalmol 55:47-63. 2010
    Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common clinical presentation of acute ischemic damage to the optic nerve...
  95. ncbi Sildenafil-associated nonarteritic anterior ischemic optic neuropathy
    Howard D Pomeranz
    Department of Ophthalmology, University of Minnesota Medical School, MMC 493, 420 Delaware Street SE, Minneapolis, MN 55455 0501, USA
    Ophthalmology 109:584-7. 2002
    To describe the clinical features of five patients who developed nonarteritic anterior ischemic optic neuropathy (NAION) after ingestion of sildenafil citrate (Viagra; Pfizer Pharmaceuticals, New York, NY).
  96. ncbi Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy
    Tsutomu Sakai
    Department of Ophthalmology, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo, 105 8461, Japan
    Graefes Arch Clin Exp Ophthalmol 245:288-92. 2007
    To examine the association between the polymorphisms of the endothelial nitric oxide synthase (eNOS) gene and the occurrence of non-arteritic anterior ischemic optic neuropathy (NAION).
  97. ncbi [Blindness caused by an ischemic optic neuropathy by spontaneous carotid dissection. Report of a case]
    Marcelo Miranda
    Departamento de Neurologia, Hospital Clinico de la Universidad de Chile, Santiago, Chile
    Rev Med Chil 131:1042-4. 2003
    ..Fundoscopy showed papilledema and a peripapillar hemorrhage, compatible with an ischemic optic neuropathy. A magnetic resonance angiography confirmed a left carotid dissection.
  98. pmc Correlations between retinal nerve fiber layer and visual field in eyes with nonarteritic anterior ischemic optic neuropathy
    Julio Deleon-Ortega
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Am J Ophthalmol 143:288-294. 2007
    To evaluate correlations between retinal nerve fiber layer (RNFL) thickness with visual field (VF) sensitivities in eyes with nonartertic anterior ischemic optic neuropathy (NAION).
  99. ncbi Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene
    Ophira Salomon
    Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ophthalmology 111:184-8. 2004
    To evaluate the association between platelet glycoprotein polymorphisms and the risks of single and second eye involvement with nonarteritic anterior ischemic optic neuropathy (NAION).
  100. pmc Nonarteritic anterior ischemic optic neuropathy: natural history of visual outcome
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine University of Iowa, Iowa City, Iowa, USA
    Ophthalmology 115:298-305.e2. 2008
    To investigate systematically the natural history of visual outcome in nonarteritic anterior ischemic optic neuropathy (NAION).
  101. ncbi Nonarteritic anterior ischemic optic neuropathy with PDE-5 inhibitors for erectile dysfunction
    M J Thurtell
    Department of Neurology, Division of Neuro ophthalmology, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Int J Impot Res 20:537-43. 2008
    ..developing, within hours of PDE-5 inhibitor use, permanent visual loss due to nonarteritic anterior ischemic optic neuropathy (NAION), a common optic neuropathy that results from ischemia of the optic nerve head...

Research Grants57

  1. IONDT FOLLOW-UP STUDY
    Kay Dickersin; Fiscal Year: 2002
    The Ischemic Optic Neuropathy Decompression Trial (IONDT), the first multicenter, prospective randomized controlled trial of newly diagnosed patients with non-artertic anterior ischemic optic neuropathy (NAION), found the optic nerve ..
  2. Novel Mitochondrial Targeted Neuroprotectants for Glaucoma
    Leonard Levin; Fiscal Year: 2009
    ..Virtually all other optic neuropathies have no effective treatment, including ischemic optic neuropathy (the most common acute optic neuropathy of the elderly), optic neuritis (the most common acute optic ..
  3. Establishing a neuroprotection model in the nonhuman primate to support translati
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2013
    ..One such condition is non-arteritic ischemic optic neuropathy (NAION), the most common cause of acute optic nerve related vision loss, for which there are limited ..
  4. Interaction of Isl1 and Pou4f2 in retinal development
    Xiuqian Mu; Fiscal Year: 2013
    ..information on why they die under certain disease conditions, such as glaucoma, optic neuritis, and ischemic optic neuropathy, and thus be able to develop novel preventive and therapeutic strategies for these diseases...
  5. Protein kinase inhibitors that promote RGC survival and function
    Donald J Zack; Fiscal Year: 2010
    ..frequently targeted in a variety of degenerative disorders such as glaucoma, optic neuritis, anterior ischemic optic neuropathy, and traumatic compression of optic nerves...
  6. Mechanisms of optic nerve stroke neuroprotection
    Steven L Bernstein; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Non-arteritic ischemic optic neuropathy (NAION), an optic nerve stroke, is the most common cause of sudden optic nerve (ON)-related vision loss, affecting 5700 Americans every year...
  7. Triazine-based compounds to promote regeneration in optic neuropathies
    Vance P Lemmon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of optic nerve-related acute loss of vision in the US;there is no effective treatment...
  8. Role of toll-like receptor signaling in retinal ischemia
    Dmitry V Ivanov; Fiscal Year: 2013
    ..large array of pathological conditions in the retina including glaucoma, diabetic retinopathy, anterior ischemic optic neuropathy and traumatic optic neuropathy...
  9. LIPOPROTEIN (A) IN VASCULAR DISEASES OF THE EYE
    Michaela K Mathews; Fiscal Year: 2013
    ..Dr. Bernstein is a renowned leader in the research of nonarteritic anterior ischemic optic neuropathy (NAION), and has developed a unique rodent photoembolic stroke model (rAION). Dr...
  10. Preclinical analysis of ischemic optic nerve treatment
    Steven L Bernstein; Fiscal Year: 2013
    Nonarteritic anterior ischemic optic neuropathy (NAION) is an optic nerve (ON) stroke and the most common cause of sudden optic nerve-related vision loss...
  11. Signaling Scaffolds and Survival in Stroke
    MICHAEL SETH KAPILOFF; Fiscal Year: 2013
    ..Thus, for example, ischemic optic neuropathy leads to retinal ganglion cell (RGC, a type of CNS neuron) dysfunction and death, and permanent loss of ..
  12. Manipulating retinal progenitor cells
    William H Klein; Fiscal Year: 2010
    ..of retinal development as well as establishing new approaches to regenerate damaged retinas and prevent or repair optic nerve degeneration in retinal pathologies such as optic neuritis, ischemic optic neuropathy, and glaucoma.
  13. Plasticity of the Visual Cortex
    Stelios Smirnakis; Fiscal Year: 2006
    ..Specific aim four will map reorganization in the visual cortex of adult humans with ischemic optic neuropathy or branch retinal artery occlusion...
  14. IONDT FOLLOW-UP STUDY
    Shalom Kelman; Fiscal Year: 2001
    The Ischemic Optic Neuropathy Decompression Trial (IONDT), the first multicenter, prospective randomized controlled trial of newly diagnosed patients with non-artertic anterior ischemic optic neuropathy (NAION), found that optic nerve ..
  15. DEVELOPMENT OF NEUROPROTECTIVE DRUGS FOR RETINAL DISEASE
    Scott Eliasof; Fiscal Year: 2000
    ..alleviation of neuronal cell death in the retina in response to a wide range of conditions including: diabetic retinopathy, glaucoma, venous and arterial occlusions of the retina, and anterior ischemic optic neuropathy.
  16. PUPILLARY AND VER INDICATORS OF OPTIC NERVE DISEASE
    H Thompson; Fiscal Year: 1980
    ..Two groups of patients will be examined (a) optic neuritis, and b) ischemic optic neuropathy and the following measurements will be made: 1. Relative Afferent Pupillary Defect...
  17. ISCHEMIC OPTIC NEUROPATHY DECOMPRESSION TRIAL
    Edward Cohn; Fiscal Year: 1992
    The Ischemic Optic Neuropathy Decompression Trial (IONDT) is a five year study designed to assess the safety and efficacy of optic nerve sheath decompression surgery (ONDS) for non-arteritic ischemic optic neuropathy, diagnosed within ..
  18. ISCHEMIC OPTIC NEUROPATHY DECOMPRESSION TRIAL
    MARK MALTON; Fiscal Year: 1992
    DESCRIPTION (Investigator's Abstract) "The Ischemic Optic Neuropathy Decompression Trial (IONDT) is a five year study designed to assess the safety and efficacy of optic nerve sheath decompression surgery (ONDS) for non-arteritic ..
  19. ISCHEMIC OPTIC NEUROPATHY DECOMPRESSION TRIAL
    James Goodwin; Fiscal Year: 1992
    The Ischemic Optic Neuropathy Decompression Trial (IONDT) is a five year study designed to assess the safety and efficacy of optic nerve sheath decompression surgery (ONDS) for non-arteritic ischemic optic neuropathy, diagnosed within ..
  20. ISCHEMIC OPTIC NEUROPATHY DECOMPRESSION TRIAL
    Anthony Arnold; Fiscal Year: 1999
    The Ischemic Optic Neuropathy Decompression Trial (IONDT) is a five year study designed to assess the safety and efficacy of optic nerve sheath decompression surgery (ONDS) for non-arteritic ischemic optic neuropathy, diagnosed within ..
  21. ISCHEMIC OPTIC NEUROPATHY DECOMPRESSION TRIAL
    Jonathan Horton; Fiscal Year: 1999
    The Ischemic Optic Neuropathy Decompression Trial (IONDT) is a five year study designed to assess the safety and efficacy of optic nerve sheath decompression surgery (ONDS) for non-arteritic ischemic optic neuropathy, diagnosed within ..
  22. ISCHEMIC OPTIC NEUROPATHY DECOMPRESSION TRIAL
    Robert Baker; Fiscal Year: 1999
    The Ischemic Optic Neuropathy Decompression Trial (IONDT) is a three year study designed to assess the safety and efficacy of optic nerve sheath decompression surgery (ONDS) for non-arteritic ischemic optic neuropathy, diagnosed within ..
  23. ISCHEMIC OPTIC NEUROPATHY DECOMPRESSION TRIAL
    Steven Newman; Fiscal Year: 1999
    The Ischemic Optic Neuropathy Decompression Trial (IONDT) is a five year study designed to assess the safety and efficacy of optic nerve sheath decompression surgery (ONDS) for non-arteritic ischemic optic neuropathy, diagnosed within ..
  24. Novel Clinical and Ocular Imaging Outcomes with Long-Term Follow-Up in MS
    Laura Balcer; Fiscal Year: 2010
    ..Aim 3: Determine how low-contrast letter acuity, RNFL thickness, and total macular volume impact vision specific and overall health-related quality of life (HRQOL) in longitudinal studies of MS and ON. ..
  25. CD8 T Cells in Rheumatoid Arthritis
    Cornelia M Weyand; Fiscal Year: 2010
    ..The goal of this proposal is to understand how such anti-inflammatory lymphocytes function and how they can be harnessed as novel therapeutic reagents in RA. ..
  26. Gene Expression in Acute and Chronic Neurologic Disease
    Donald Gilden; Fiscal Year: 2008
    ..This concerted effort is focused on prospective studies to delineate the cause, pathogenesis and eventual prevention of viral and demyelinating diseases of the human nervous system. ..
  27. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    George Cioffi; Fiscal Year: 2008
    ....
  28. UVEAL VASCULATURE: OPTIC NERVE MICROCIRCULATION
    George Cioffi; Fiscal Year: 2003
    ..The model will also allow the assessment of the combined effects of optic nerve ischemia and elevated 10P. Finally, possible pharmacologic blockers of decreased optic nerve blood flow and ischemia can be evaluated. ..
  29. Visual Dysfunction and Quality of Life in MS
    Laura Balcer; Fiscal Year: 2003
    ..This proposal will provide a crucial foundation for future studies of vision in MS that will involve longitudinal assessment. ..
  30. EXCITATORY AMINO ACIDS IN GLAUCOMA
    Alan Laties; Fiscal Year: 2004
    ..These experiments will help test the central hypothesis--for if one can block the effects of IOP elevation with glutamate antagonists, then elevated 10P may toxic glutamate levels ganglion cell loss. ..
  31. Hereditary Benign Intraepithelial Dyskeratosis
    Wendi Lambert; Fiscal Year: 2005
    ..A limited number of extremely promising candidate genes will be transfected into an established cell culture system to test candidate genes on their ability form foci, which is consistent with the HBID phenotype. ..
  32. IMMUNOPATHWAYS IN ACUTE CORONARY SYNDROMES
    Cornelia Weyand; Fiscal Year: 2005
    ..abstract_text> ..
  33. A novel in vitro model of thyroid ophthalmopathy
    Steven Feldon; Fiscal Year: 2005
    ..abstract_text> ..
  34. CLINICAL CHARACTERIZATION&GENETICS OF OPTIC NERVE DRUSEN
    Bradley Katz; Fiscal Year: 2005
    ..OND probably renders the optic nerve susceptible to other diseases of the optic nerve, such as ischemic optic neuropathy and glaucoma. It is hypothesized that OND is a significant source of visual disability in the U.S...
  35. GENE EXPRESSION IN AXOTOMIZED RETINAL GANGLION CELLS
    Leonard Levin; Fiscal Year: 2004
    ..As many of these diseases (e.g., normal-tension glaucoma and ischemic optic neuropathy) are not easily treatable, determination of the regulation of cell destructive and protective mechanisms ..
  36. Training for US Cochrane Contributors and Others
    Kay Dickersin; Fiscal Year: 2006
    ..The applicant will collaborate and partner with investigators associated with the EPCs in all stages of the project. [unreadable] [unreadable]..
  37. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
    ..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..
  38. Longitudinal Assessment of Visual Function in MS
    Laura Balcer; Fiscal Year: 2007
    ....
  39. Translating Evidence to Quality Care: Getting the Message to Your Constituency
    Kay Dickersin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..