Genomes and Genes
Summary: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
Publications309 found, 100 shown here
- Optical coherence tomography and disease subtype in multiple sclerosisM Pulicken
Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
Neurology 69:2085-92. 2007To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON).
- Optical coherence tomography versus automated perimetry for follow-up of optic neuritisSusana Noval
Department of Ophthalmology, Ramon y Cajal Hospital, Madrid, Spain
Acta Ophthalmol Scand 84:790-4. 2006To evaluate the usefulness of optical coherence tomography (OCT) for follow-up of optic neuritis (ON) compared with subjective visual function tests.
- Improvement in conduction velocity after optic neuritis measured with the multifocal VEPE Bo Yang
Department of Psychology, Columbia University, New York, New York 10027, USA
Invest Ophthalmol Vis Sci 48:692-8. 2007To test the efficacy of the multifocal visual evoked potential (mfVEP) technique after long-term latency changes in optic neuritis (ON)/multiple sclerosis (MS), mfVEPs were recorded in 12 patients with ON/MS.
- Diagnostic accuracy of retinal abnormalities in predicting disease activity in MSJorge Sepulcre
Department of Neurology and Neurosurgery, University of Navarra, Pamplona, Spain
Neurology 68:1488-94. 2007..To assess the association between the thickness of the retinal nerve fiber layer (RNFL), assessed by optical coherence tomography (OCT), retinal periphlebitis (RP), and multiple sclerosis (MS) disease activity...
- Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosisV Pueyo
Isabel la Catolica, Zaragoza, Spain
Mult Scler 14:609-14. 2008To quantify axonal loss in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS), with and without a history of optic neuritis, by means of ocular imaging technologies.
- NMO-IgG predicts the outcome of recurrent optic neuritisM Matiello
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Neurology 70:2197-200. 2008..determine the prognostic value of neuromyelitis optica (NMO)-immunoglobulin G (IgG) in patients with recurrent optic neuritis (ON)...
- An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomographyAndrew P D Henderson
NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
Brain 131:277-87. 2008..Of the patients with secondary progressive MS, 14 had clinical history of optic neuritis (ON) in a single eye; the remaining patients had not had ON...
- Correlation between morphological and functional retinal impairment in multiple sclerosis patientsV Parisi
Cattedra di Clinica Oculistica, Universita di Roma Tor Vergata, Italy
Invest Ophthalmol Vis Sci 40:2520-7. 1999To assess whether a correlation exists between optic nerve fiber layer (NFL) thickness and the retinal or visual pathway function in multiple sclerosis (MS) patients previously affected by optic neuritis.
- Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlationsHanna Zimmermann
NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charité Universitätsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany
Mult Scler 19:443-50. 2013..An influence of optic neuritis is well documented but sparsely investigated...
- Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patientsMarkus Bock
Cecilie Vogt Clinic, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
Clin Neurol Neurosurg 112:647-52. 2010..nerve fiber layer thickness (RNFLT) loss are different in MS compared to other diseases such as glaucoma and data on RNFLT loss in MS patients with or without optic neuritis (ON/NON) have remained inconsistent or even contradictory.
- Correlation between morphological and functional retinal impairment in patients affected by ocular hypertension, glaucoma, demyelinating optic neuritis and Alzheimer's diseaseVincenzo Parisi
Clinica Oculistica Università di Roma Tor Vergata, Italy
Semin Ophthalmol 18:50-7. 2003..ERG recordings) performed in patients affected by ocular hypertension (OHT), glaucoma (OAG), demyelinating optic neuritis (MSON), and Alzheimer's disease (AD) are reported...
- Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritisSven Jarius
Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
J Neurol Sci 298:158-62. 2010....
- Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosisBryn M Burkholder
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Arch Neurol 66:1366-72. 2009..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
- Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritisKevin Rostasy
Division of Pediatric Neurology and Inherited Metabolic Disorders, Department of Pediatrics IV, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Arch Neurol 69:752-6. 2012To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG)in pediatric patients with isolated and recurrent optic neuritis(ON).
- Optic nerve diffusion tensor imaging in optic neuritisS Anand Trip
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 30:498-505. 2006..oblique multislice (ZOOM) echoplanar imaging) was applied to 25 patients with a single unilateral episode of optic neuritis at least one year previously, and 15 controls...
- Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virusKenneth S Shindler
Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA
J Neuropathol Exp Neurol 70:470-80. 2011..A demyelinating MHV strain induces optic neuritis, but whether this is due to the retrograde axonal transport of viral particles to the retina or due to ..
- Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritisEstelle Bettelli
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 197:1073-81. 2003..an autoimmune disease of the central nervous system (CNS) that in many patients first presents clinically as optic neuritis. The relationship of optic neuritis to MS is not well understood...
- Long-term remyelination after optic neuritis: A 2-year visual evoked potential and psychophysical serial studyA Brusa
Department of Clinical Neurophysiology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Brain 124:468-79. 2001..at 3-month intervals for the first year and at 6-month intervals for the second year, after an episode of optic neuritis. The object was to confirm previous evidence for a progressive shortening of visual evoked potential (VEP) ..
- Electrophysiological evidence for heterogeneity of lesions in optic neuritisAlexander Klistorner
Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
Invest Ophthalmol Vis Sci 48:4549-56. 2007To examine the natural history of multifocal visual evoked potentials (mfVEPs) within 12 months of the first episode of optic neuritis (ON) in patients with possible multiple sclerosis (MS).
- Optical coherence tomography: a window into the mechanisms of multiple sclerosisElliot M Frohman
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
Nat Clin Pract Neurol 4:664-75. 2008....
- Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritisScott Kolbe
The Howard Florey Institute, University of Melbourne, Melbourne, Australia
Neuroimage 45:679-86. 2009..b>Optic neuritis, a condition characterised by inflammatory demyelination of the optic nerve, is one of the commonest sites of ..
- Demyelination affects temporal aspects of perception: an optic neuritis studyNoa Raz
The Agnes Ginges Center for Human Neurogenetics, Laboratory for Neuroimmunology, The Department of Neurology, Jerusalem, Israel
Ann Neurol 71:531-8. 2012Visual Evoked Potentials (VEPs) following optic neuritis (ON) remain chronically prolonged, although standard visual tests indicate full recovery...
- Chromatic discrimination losses in multiple sclerosis patients with and without optic neuritis using the Cambridge Colour TestAna Laura de Araújo Moura
Depto Psicologia Experimental, Instituto de Psicologia, Universidade de Sao Paulo, Sao Paulo, Brasil
Vis Neurosci 25:463-8. 2008..chromatic discrimination in multiple sclerosis (MS) patients both with (ON) and without (no ON) a history of optic neuritis using the Cambridge color test (CCT)...
- Clinical application of the multifocal VEPsY Betsuin
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
Curr Eye Res 22:54-63. 2001..CONCLUSIONS: Multifocal VEPs summed within four quadrants can be used for an objective evaluation of the visual fields. The testing can be obtained in 4 min with no pain or discomfort to the patient...
- Recovery from optic neuritis: an ROI-based analysis of LGN and visual cortical areasKirsten Korsholm
Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, 2650 Hvidovre, Denmark
Brain 130:1244-53. 2007b>Optic neuritis (ON) is the first clinical manifestation in approximately 20% of patients with multiple sclerosis (MS)...
- Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virusKenneth S Shindler
FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Virol 82:8882-6. 2008b>Optic neuritis (ON), an inflammatory demyelinating optic nerve disease, occurs in multiple sclerosis (MS). Pathological mechanisms and potential treatments for ON have been studied via experimental autoimmune MS models...
- Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivitiesR T Naismith
Department of Neurology, Washington University, Saint Louis, MO, USA
Neurology 72:589-94. 2009..the potential of directional diffusivities from diffusion tensor imaging (DTI) to predict clinical outcome of optic neuritis (ON), and correlate with vision, optical coherence tomography (OCT), and visual evoked potentials (VEP).
- Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritisStephanie B Syc
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Brain 135:521-33. 2012..in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal layers following acute optic neuritis remains largely unexplored...
- Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetryTheodora A M Siepman
Department of Neurology, MS Centre ErasMS, Erasmus MC, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
J Neurol 257:1654-60. 2010..Twenty-eight patients (43%) had a history of optic neuritis (ON). Adjustments were made for age and disease duration...
- Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosisL K Fisniku
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
Brain 131:808-17. 2008Clinically isolated syndromes (CIS), such as optic neuritis, brainstem or spinal cord syndromes are frequently the first clinical presentations of multiple sclerosis...
- Selective magnetization transfer ratio decrease in the visual cortex following optic neuritisBertrand Audoin
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Brain 129:1031-9. 2006..analysis of GM MTR maps in a group of 80 patients studied within 6 months of presenting with isolated optic neuritis and compared the findings with those seen in 50 age- and sex-matched healthy controls...
- Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study GroupL D Jacobs
Department of Neurology, State University of New York School of Medicine at Buffalo and Buffalo General Hospital, 14203, USA
N Engl J Med 343:898-904. 2000..Treatment with interferon beta has been shown to help patients with established multiple sclerosis, but it is not known whether initiating treatment at the time of a first clinical demyelinating event is of value...
- Evolving management of optic neuritis and multiple sclerosisAnthony C Arnold
Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90095 7005, USA
Am J Ophthalmol 139:1101-8. 2005To review the relation of optic neuritis to multiple sclerosis (MS) and the indications, modalities, and results of therapy for optic neuritis, for both visual and general neurologic function.
- Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritisKenneth S Shindler
Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104 6100, United States
Exp Eye Res 87:208-13. 2008b>Optic neuritis is an inflammatory disease of the optic nerve that often occurs in patients with multiple sclerosis and leads to permanent visual loss mediated by retinal ganglion cell (RGC) damage...
- SIRT1 activation confers neuroprotection in experimental optic neuritisKenneth S Shindler
F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania 19104, USA
Invest Ophthalmol Vis Sci 48:3602-9. 2007..damage and loss of neurons correlate with permanent vision loss and neurologic disability in patients with optic neuritis and multiple sclerosis (MS)...
- Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomographyF Costello
Department of Clinical Neurosciences and Ophthalmology, The University of Calgary and Hotchkiss Brain Institute, Calgary, Alberta, Canada
Mult Scler 14:893-905. 2008b>Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography...
- Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosisJ Toledo
Department of Neurology and Neurosurgery, Clinica Universitaria de Navarra and Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Mult Scler 14:906-12. 2008....
- Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritisSimon J Hickman
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
AJNR Am J Neuroradiol 26:951-6. 2005..DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging.
- Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritisA Petzold
Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
J Neurol Neurosurg Psychiatry 81:109-11. 2010The clinical course of immune mediated optic neuritis (ON) will depend on the specific underlying inflammatory disease. These disorders have traditionally been classified according to clinical and MRI findings...
- Transient raise of endothelin-1 plasma level and reduction of ocular blood flow in a patient with optic neuritisTimo Haufschild
University Eye Clinic, Basel, Switzerland
Ophthalmologica 217:451-3. 2003To analyze how far an ischemic component might have been involved in optic neuritis.
- Fellow eye changes in optic neuritis correlate with the risk of multiple sclerosisA Klistorner
Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
Mult Scler 15:928-32. 2009..The clinically unaffected (fellow) eye of patients with unilateral optic neuritis (ON) may reflect the status of normal-appearing white matter in the CNS, which can be assessed ..
- Distinctive retinal nerve fibre layer and vascular changes in neuromyelitis optica following optic neuritisA J Green
Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
J Neurol Neurosurg Psychiatry 80:1002-5. 2009This is a cross sectional study comparing the retinal features of optic neuritis (ON) between 20 multiple sclerosis (MS) and 16 neuromyelitis optica (NMO) patients with a history of ON (visual acuity at time of attack >20/100) matched ..
- Lyme optic neuritisFrederic Blanc
Department of Neurology, University Hospital of Strasbourg, Strasbourg, France
J Neurol Sci 295:117-9. 2010Lyme optic neuritis (ON) is a rare disease and only a few cases have been reported. We describe two cases of isolated Lyme ON, one with recurrence 9 months after the appearance of initial symptoms...
- An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritisKatharina Hein
Department of Neurology, Georg August University, Gottingen, Germany
Invest Ophthalmol Vis Sci 53:157-63. 2012..was to evaluate the ability and accuracy of spectral domain optical coherence tomography (OCT) for in vivo monitoring of retinal ganglion cell degeneration in a rat model of myelin oligodendrocyte glycoprotein-induced optic neuritis.
- Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritisScott C Kolbe
Department of Physiology, Monash University, Clayton, Vic, 3800, Australia
Invest Ophthalmol Vis Sci 53:825-32. 2012To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON).
- Latency delay of visual evoked potential is a real measurement of demyelination in a rat model of optic neuritisYuyi You
Department of Ophthalmology, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
Invest Ophthalmol Vis Sci 52:6911-8. 2011..To investigate the relationship between size of demyelinated lesion, extent of axonal loss, and degree of latency delay of visual evoked potentials (VEPs) in a rat model of experimental demyelination...
- Clinical practice. Optic neuritisLaura J Balcer
Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
N Engl J Med 354:1273-80. 2006
- Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypesJeffrey M Gelfand
University of California, San Francisco Department of Neurology, Multiple Sclerosis Center, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 7:e36847. 2012....
- Treatment of optic neuritis by plasma exchange (add-on) in neuromyelitis opticaHarold Merle
Service d Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Hopital Pierre Zobda Quitman, Martinique, France
Arch Ophthalmol 130:858-62. 2012To assess the contribution of plasma exchange (PE) in association (add-on) with pulsed intravenous corticosteroids in acute optic neuritis of neuromyelitis optica (NMO) and limited forms of NMO.
- Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysisY Jin
Neuroepidemiology Unit, Karolinska Institute, Huddinge University Hospital, S 141 86, Huddinge, Sweden
J Neurol Sci 181:56-64. 2000To quantify and characterize seasonal variation in monosymptomatic optic neuritis (MON) onsets, multiple sclerosis (MS) onsets and MS exacerbations (MSE), a meta-analysis was performed, using established methods and pooling weighted ..
- Visual resting-state network in relapsing-remitting MS with and without previous optic neuritisAntonio Gallo
Department of Neurological Sciences, Second University of Naples, Naples, Italy
Neurology 79:1458-65. 2012To investigate functional connectivity of the visual resting-state network (V-RSN) in normal-sighted relapsing-remitting multiple sclerosis (RRMS) patients with and without previous optic neuritis (ON).
- Remyelination of optic nerve lesions: spatial and temporal factorsAlexandr Klistorner
Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
Mult Scler 16:786-95. 2010b>Optic neuritis provides an in vivo model to study demyelination. The effects of myelin loss and recovery can be measured by the latency of the multifocal visual evoked potentials...
- Interferon beta-1a for early multiple sclerosis: CHAMPS trial subgroup analysesroy W Beck
CHAMPS Analysis Center, Jaeb Center for Health Research, Tampa, FL 33613, USA
Ann Neurol 51:481-90. 2002..Adjusted rate ratios for the development of clinically definite multiple sclerosis in the optic neuritis, brainstem-cerebellar, and spinal cord syndrome subgroups were 0.58 (p = 0.05), 0.40 (p = 0.03), and 0...
- Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in ratsArabinda Das
Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
J Neurochem 124:133-46. 2013b>Optic neuritis (ON), which is an acute inflammatory autoimmune demyelinating disease of the central nervous system (CNS), often occurs in multiple sclerosis (MS)...
- Optic neuritis and risk of MS: differential diagnosis and managementBenjamin J Osborne
Departments of Neurology and Ophthalmology, Georgetown University Medical Center, Washington, DC, USA
Cleve Clin J Med 76:181-90. 2009b>Optic neuritis, a cause of sudden vision loss, often heralds the onset of multiple sclerosis (MS) within the next few years...
- Dissecting structure-function interactions in acute optic neuritis to investigate neuroplasticityThomas Jenkins
Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, United Kingdom
Hum Brain Mapp 31:276-86. 2010..We combined them to investigate why patients with optic neuritis (ON) exhibit a wide variation in severity of acute visual loss, with the following objectives: (1) To ..
- Cortical neuroplasticity in patients recovering from acute optic neuritisKirsten Korsholm
Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark
Neuroimage 42:836-44. 2008Patients with optic neuritis (ON) undergo cortical and subcortical neuroplasticity as revealed by functional magnetic resonance imaging (fMRI)...
- Systemic lupus erythematosus-associated optic neuritis: clinical experience and literature reviewYen Ching Lin
Department of Ophthalmology, Suao Veterans Hospital, I Lan, Taiwan
Acta Ophthalmol 87:204-10. 2009This study aimed to evaluate the visual outcome of optic neuritis in patients with systemic lupus erythematosus (SLE).
- Normal and abnormal fMRI activation patterns in the visual cortex after recovery from optic neuritisNetta Levin
Department of Neurobiology, Hebrew University, Jerusalem, Israel
Neuroimage 33:1161-8. 2006Recovery to normal or near normal visual acuity after an optic neuritis episode is common, despite frequent persistence of conduction abnormalities, evident in prolonged visual evoked potential (VEP) latencies...
- Using retinal architecture to help characterize multiple sclerosis patientsFiona Costello
Departments of Clinical Neurosciences and Surgery, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta
Can J Ophthalmol 45:520-6. 2010....
- MRI demonstrates restricted diffusion in distal optic nerve in atypical optic neuritisOriel Spierer
Ophthalmology Department, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
J Neuroophthalmol 30:31-3. 2010..The presence of restricted diffusion is helpful in excluding a neoplastic cause of a thickened optic nerve...
- Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritisAmena W Smith
Departments of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Invest Ophthalmol Vis Sci 52:4935-41. 2011b>Optic neuritis (ON), inflammation of the optic nerve, is strongly associated with the pathogenesis of multiple sclerosis (MS) and is initiated by the attack of autoreactive T cells against self-myelin antigens, resulting in demyelination, ..
- Optic neuritisD Pau
Department of Ophthalmology, The Methodist Hospital, Houston, TX 77030, USA
Eye (Lond) 25:833-42. 2011The aim of this study is to provide a clinical update on optic neuritis (ON), its association with multiple sclerosis (MS), and neuromyelitis optica (NMO).
- Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapyXiaoping Qi
Department of Ophthalmology, University of Florida, College of Medicine, Gainesville, FL 32610 0284, USA
Invest Ophthalmol Vis Sci 48:5360-70. 2007To test in mice with experimental autoimmune encephalomyelitis (EAE) a strategy designed to treat patients at risk for axonal degeneration and persistent visual loss from optic neuritis and multiple sclerosis.
- Independent patterns of damage to retinocortical pathways in multiple sclerosis without a previous episode of optic neuritisAldina Reis
Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image IBILI, University of Coimbra, Azinhaga de Santa Comba, Celas, 3000 548 Coimbra, Portugal
J Neurol 258:1695-704. 2011..patterns of subclinical visual impairment in patients with MS with and without clinically associated previous optic neuritis (ON)...
- Magnetisation transfer ratio in optic neuritis is associated with axonal loss, but not with demyelinationA Klistorner
Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
Neuroimage 56:21-6. 2011..mfVEP) (measure of optic nerve conduction) and Retinal Nerve Fiber Layer (RNFL) thickness (measure of axonal damage) we investigated the effect of neurodegeneration and demyelination on MTR after an episode of optic neuritis (ON).
- Comparison of retinal nerve fiber layer and central macular thickness measurements among five different optical coherence tomography instruments in patients with multiple sclerosis and optic neuritisGeorge M Watson
Department of Ophthalmology and Vision Science, University of California Davis Eye Center, Sacramento, California 95817, USA
J Neuroophthalmol 31:110-6. 2011..the mean average optic nerve retinal nerve fiber layer (RNFL) thickness in the eyes of patients with a history of optic neuritis and/or multiple sclerosis (MS) using 5 commercially available optical coherence tomography (OCT) instruments.
- Quantifying axonal loss after optic neuritis with optical coherence tomographyFiona Costello
Division of Neurology, Ottawa, Ontario Canada
Ann Neurol 59:963-9. 2006To determine to what degree changes in retinal nerve fiber layer (RNFL) thickness after optic neuritis (ON) correlate with either visual recovery or impairment.
- Optic neuritis is nothing to sneeze atMichael S Vaphiades
Departments of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Surv Ophthalmol 52:106-10. 2007A 36-year-old man developed acute visual loss, mimicking an optic neuritis in the left eye...
- Sustained motion perception deficit following optic neuritis: Behavioral and cortical evidenceN Raz
Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
Neurology 76:2103-11. 2011To assess the recovery process in patients after an acute optic neuritis (ON) attack, comparing static and dynamic visual functions.
- Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosisHideto Nakajima
Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan
BMC Neurol 10:45. 2010..Central scotoma is recognized as a characteristic visual field defect pattern of optic neuritis (ON), however, the differing pathogenic mechanisms of NMO and MS may result in different patterns of visual ..
- A case of secondary syphilis presenting as optic neuritisMonica Bandettini di Poggio
Department of Neurology, Ophthalmology and Genetics, San Martino Hospital, University of Genoa, Via De Toni 5, 16132, Genoa, Italy
Neurol Sci 31:365-7. 2010..We also support the view that the presence of ocular involvement in syphilitic patients is suggestive of involvement of the CNS and should be considered synonymous with neurosyphilis...
- Management of acute optic neuritisS J Hickman
NMR Research Unit, Institute of Neurology, University College London, London, UK
Lancet 360:1953-62. 2002b>Optic neuritis is a common condition that causes reversible loss of vision. It can be clinically isolated or can arise as one of the manifestations of multiple sclerosis...
- Optical coherence tomography of the retina: applications in neurologyPanitha Jindahra
The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Curr Opin Neurol 23:16-23. 2010..The application of optical coherence tomography imaging of the retina in multiple sclerosis, neuromyelitis optica, Alzheimer disease, and Parkinson disease are reviewed...
- Heterogeneous pattern of retinal nerve fiber layer in multiple sclerosis. High resolution optical coherence tomography: potential and limitationsNermin Serbecic
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
PLoS ONE 5:e13877. 2010..of RNFL be detected in all MS patients, even in early disease courses and in all MS subtypes? (3) Does an optic neuritis (ON) or focal lesions along the visual pathways, which are both very common in MS, limit the predication of ..
- Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2Mandana Zandian
Department of Surgery, Cedars Sinai Burns and Allen Research Institute, Center for Neurobiology and Vaccine Development, Los Angeles, California, USA
Invest Ophthalmol Vis Sci 50:3275-82. 2009..The present study was conducted to determine whether the ocular infection with this recombinant virus induces optic neuritis independent of virus dose, major histocompatibility complex (MHC) background, or sex.
- Multifocal VEP and OCT in optic neuritis: a topographical study of the structure-function relationshipAlexander Klistorner
Department of Ophthalmology, Save Sight Institute, University of Sydney, P O Box 4337, Sydney, NSW 2001, Australia
Doc Ophthalmol 118:129-37. 2009To investigate topographical relationship between amplitude of multifocal visual evoked potentials (mfVEP) and retinal nerve fibre layer (RNFL) thickness following acute optic neuritis (ON).
- Isolated optic neuritis from an identified Gnathostoma spinigerumW Chuenkongkaew
Department of Ophthalmology, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand
Eur J Ophthalmol 17:130-2. 2007To describe a patient with isolated monocular optic neuritis caused by an identified Gnathostoma spinigerum infestation.
- Correlation between optic disc atrophy and aetiology: anterior ischaemic optic neuropathy vs optic neuritisE Z Rath
Department of Ophthalmology, Western Galilee Medical Center, Nahariya, Israel
Eye (Lond) 17:1019-24. 2003The morphologic features of swollen disc in the acute stage of optic neuritis and anterior ischaemic optic neuropathy (AION) have been extensively investigated in contrast to the morphologic features of optic disc atrophy after these ..
- Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57BL/6 mouseHui Shao
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Kentucky 40202, USA
Invest Ophthalmol Vis Sci 45:4060-5. 2004..To determine the relationship between optic neuritis (ON) and EAE, we examined the incidence of ON in C57BL/6 (B6) mice immunized with a myelin oligodendrocyte/..
- Optic disc cupping after optic neuritis evaluated with optic coherence tomographyG Rebolleda
Ophthalmology Department, Glaucoma Unit, Hospital Ramon y Cajal, Madrid, Spain
Eye (Lond) 23:890-4. 2009To determine whether the optic disc experiences cupping after an episode of optic neuritis as assessed by optical coherence tomography (OCT).
- Visual function at baseline and 1 month in acute optic neuritis: predictors of visual outcomeM J Kupersmith
Neuro Ophthalmology, INN at Roosevelt Hospital and Albert Einstein School of Medicine, New York, NY 10019, USA
Neurology 69:508-14. 2007..criteria in a clinical trial to test potential neuroprotection or myelin repair agents in patients with optic neuritis. To determine whether moderate-to-severe dysfunction in one or more visual measures at baseline or 1 month ..
- Optic neuritis in adults and childrenJeffrey A Boomer
Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma School of Medicine, Oklahoma City, OK 73104, USA
Semin Ophthalmol 18:174-80. 2003Most ophthalmologists will encounter optic neuritis in the course of their practice. The disease behaves very differently in children versus adults...
- Adaptive cortical plasticity in higher visual areas after acute optic neuritisAhmed T Toosy
Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
Ann Neurol 57:622-33. 2005..applying visual functional magnetic resonance imaging (fMRI) and optic nerve MRI to 20 patients with acute optic neuritis at baseline, 1, 3, 6, and 12 months...
- The presentation, aetiology, management and outcome of optic neuritis in an Asian populationJ C Wang
Singapore National Eye Centre, Singapore
Clin Experiment Ophthalmol 29:312-5. 2001To analyse the presentation, aetiology, management and outcome of patients with optic neuritis (ON) in Singapore.
- Low conversion rate to multiple sclerosis in idiopathic optic neuritis patients in TaiwanYen Ching Lin
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
Jpn J Ophthalmol 50:170-5. 2006To investigate the clinical characteristics of patients with idiopathic optic neuritis (ON) in Taiwan and to assess the conversion rate to multiple sclerosis (MS) in these patients.
- Axonal loss and myelin in early ON loss in postacute optic neuritisAlexander Klistorner
Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
Ann Neurol 64:325-31. 2008..the relation between retinal nerve fiber layer (RNFL) thickness and latency and amplitude of multifocal visual-evoked potentials (mfVEPs) in the postacute stage of optic neuritis in patients with early or possible multiple sclerosis.
- Acute axonal damage predicts clinical outcome in patients with multiple sclerosisE T Lim
Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Mult Scler 11:532-6. 2005..fluid (CSF) neurofilament heavy chain (NfH(SM134) and NfH(SM135)) levels relate to clinical outcome in optic neuritis (ON) and multiple sclerosis (MS) relapse patients treated with high dose oral methylprednisolone; and (2) to ..
- Differences in retinal nerve fiber layer atrophy between multiple sclerosis subtypesFiona Costello
Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
J Neurol Sci 281:74-9. 2009..To determine whether retinal nerve fiber layer (RNFL) atrophy in the afferent visual pathway may complement existing tools used to describe and characterize differences across MS subtypes...
- Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patientsMichal Laron
University of Houston, College of Optometry, Houston, Texas 77204 2020, USA
Mult Scler 16:412-26. 2010..Multifocal visual evoked potentials (mfVEP) measure local response amplitude and latency in the field of vision...
- Optic radiation changes after optic neuritis detected by tractography-based group mappingOlga Ciccarelli
Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
Hum Brain Mapp 25:308-16. 2005..This study investigated in vivo the optic radiations in patients affected by optic neuritis using fast marching tractography (FMT), a diffusion magnetic resonance imaging (MRI) fiber tracking method, ..
- Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritisMadhan Kolappan
NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
J Neurol 256:305-19. 2009..Retinal nerve fibre layer (RNFL) thickness is usually reduced following an episode of optic neuritis. Techniques such as optical coherence tomography, scanning laser polarimetry, and confocal scanning laser ..
- Plasma exchange for severe optic neuritis: treatment of 10 patientsK Ruprecht
Clinical Research Unit for Multiple Sclerosis and Neuroimmunology, Julius Maximilians University, Josef Schneider Str 11, 97080 Wurzburg, Germany
Neurology 63:1081-3. 2004The authors reviewed a series of 10 consecutive patients treated with plasma exchange (PE) for acute, severe optic neuritis (ON) largely unresponsive to previous high-dose IV glucocorticosteroids...
- Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 miceGrazyna Adamus
Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
Invest Ophthalmol Vis Sci 53:406-12. 2012b>Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal injury in the optic nerve and leads to apoptotic retinal ganglion cell (RGC) death, which contributes to the persistence of visual loss...
- Early factors associated with axonal loss after optic neuritisAndrew P D Henderson
NMR Research Unit, University College London, Institute of Neurology, London, United Kingdom
Ann Neurol 70:955-63. 2011Acute optic neuritis due to an inflammatory demyelinating lesion of the optic nerve is often seen in association with multiple sclerosis...
- Predicting the outcome of optic neuritis: evaluation of risk factors after 30 years of follow-upPetra Nilsson
Department of Neurology, University Hospital, 22185 Lund, Sweden
J Neurol 252:396-402. 2005Multiple sclerosis (MS) is a common disease with considerable risk for disability. Optic neuritis (ON) is a common first symptom of MS but it can also remain an isolated episode...
- Retinal nerve fiber layer thickness and spatial and temporal contrast sensitivity in multiple sclerosisHarold Merle
Service d Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Martinique, France
Eur J Ophthalmol 20:158-66. 2010..To measure peripapillary retinal nerve fiber layer (RNFL) thickness and spatial and temporal contrast sensitivity in multiple sclerosis (MS) taking into account previous history of optic neuropathy (ON)...
- Tracking the recovery of local optic nerve function after optic neuritis: a multifocal VEP studyD C Hood
Department of Psychology, Columbia University, College of Physicians and Surgeons, New York, New York
Invest Ophthalmol Vis Sci 41:4032-8. 2000To explore the multifocal visual evoked potential (mVEP) as a technique for tracking local optic nerve damage after unilateral optic neuritis (ON).
- Bilateral optic neuritis and Guillain-Barré syndrome following an acute Mycoplasma pneumoniae infectionRicardo C Ginestal
J Neurol 251:767-8. 2004
- CNS Demyelinating Autoimmunity Targeting Water Channel ComplexesSEAN JOSEPH PITTOCK; Fiscal Year: 2013..It is characterized by recurrent episodes of optic neuritis and transverse myelitis, resulting in blindness and paraplegia in most patients, and it is frequently ..
- Novel Mitochondrial Targeted Neuroprotectants for GlaucomaLeonard Levin; Fiscal Year: 2009..treatment, including ischemic optic neuropathy (the most common acute optic neuropathy of the elderly), optic neuritis (the most common acute optic neuropathy of the young), and many others...
- Experimental Optic Neuritis: Gene TherapyJohn Guy; Fiscal Year: 2011..Moreover, the mechanisms leading to neurodegeneration in optic neuritis and MS are poorly understood...
- Mechanism of SIRT1 activator mediated neuroprotection of retinal ganglion cellsKenneth S Shindler; Fiscal Year: 2013b>Optic neuritis is an inflammatory demyelinating disease of the optic nerve that occurs in association with the central nervous system (CNS) demyelinating disease multiple sclerosis (MS) and leads to permanent visual loss in up to 40% of ..
- RETINAL GANGLION CELL PLASTICITY IN GLAUCOMAVittorio Porciatti; Fiscal Year: 2013..of glaucoma, the ND4 transgenic mouse of multiple sclerosis, and the MOG-specific TCR transgenic mouse of optic neuritis. Controls will be corresponding non-pathological congenic mice...
- Aquaporin-4 in NMO Optic Neuritis: Pathogenesis and New TherapiesAlan S Verkman; Fiscal Year: 2013..an autoimmune, inflammatory demyelinating disease primarily affecting optic nerve and spinal cord, producing optic neuritis and blindness. A defining feature of NMO is the presence of serum autoantibodies (NMO-IgG) against AQP4...
- Interaction of Isl1 and Pou4f2 in retinal developmentXiuqian Mu; Fiscal Year: 2013..we will also obtain valuable information on why they die under certain disease conditions, such as glaucoma, optic neuritis, and ischemic optic neuropathy, and thus be able to develop novel preventive and therapeutic strategies for ..
- Ocular HSV: Role of virus and IL-2 in Optic neuritisHomayon Ghiasi; Fiscal Year: 2010..3. Determine if a recombinant HSV-1 expressing IL-4 (HSV-IL-4) can protect against HSV-IL-2-induced demyelination, while a similarly made recombinant virus expressing IFN-gamma is not beneficial. ..
- Protein kinase inhibitors that promote RGC survival and functionDonald J Zack; Fiscal Year: 2010..their axons in optic nerves are frequently targeted in a variety of degenerative disorders such as glaucoma, optic neuritis, anterior ischemic optic neuropathy, and traumatic compression of optic nerves...
- Development of visual and neurologic outcome measures in pediatric MSAMY TARA WALDMAN; Fiscal Year: 2013..visual and neurologic function reflect axonal and neuronal loss as captured by OCT, adjusting for a history of optic neuritis. Specific Aim 3 - Validate the presence or absence of axonal loss as measured by OCT using other ..
- Administrative Supplements for Research on Sex/Gender Differences(admin supp)Peter Koulen; Fiscal Year: 2013DESCRIPTION (provided by applicant): Degeneration or damage of the optic nerve and the retina due to optic neuritis is a leading cause of visual loss and blindness in the United States and worldwide associated with multiple sclerosis and ..
- DEVELOPMENTAL CONTROL OF AXON REGENERATION IN RGCsJeffrey L Goldberg; Fiscal Year: 2010..treatments to promote RGC regeneration after injury in ocular diseases including glaucoma, retinal ischemia, optic neuritis and optic neuropathies, and to extend our understanding to more broadly promote CMS regeneration, for example ..
- Multi-Modality, Quantitative MRI to Assess the Human Optic Nerve in vivoSeth A Smith; Fiscal Year: 2013b>Optic Neuritis, marked by idiopathic, sudden inflammation of the optic nerve (ON), is the most commonly presenting symptom of MS...
- 2nd International Pathogenesis of Rare Neuroimmunologic DisordersDouglas Kerr; Fiscal Year: 2006..myelitis, HTLV-1 associated myelopathy, stiff person syndrome[unreadable] (SPS), neuromyelitis optica (NMO), optic neuritis (ON), multiple sclerosis (MS), acute disseminated[unreadable] encephalomyelitis (ADEM), Hashimoto?s ..
- Role of Calpain in the Pathogenesis of Experimental Optic NeuritisAMENA WESTON SMITH; Fiscal Year: 2011b>Optic neuritis (ON), inflammation of the optic nerve, is due to influx of autoreactive T cells and other immune cells...
- OPTIC NERVE MYELINATIONBen A Barres; Fiscal Year: 2012..how myelination is regulated may suggest new ways of enhancing remyelination after injury or diseases such as optic neuritis and Multiple Sclerosis...
- Kruppel-like Transcription Factors in Retinal Ganglion Cell RegenerationJeffrey L Goldberg; Fiscal Year: 2013..treatments to promote RGC regeneration after injury in ocular diseases including glaucoma, retinal ischemia, optic neuritis and optic neuropathies, and to extend our understanding to more broadly promote CNS regeneration, for example ..
- Manipulating retinal progenitor cellsWilliam H Klein; Fiscal Year: 2010..of retinal development as well as establishing new approaches to regenerate damaged retinas and prevent or repair optic nerve degeneration in retinal pathologies such as optic neuritis, ischemic optic neuropathy, and glaucoma.
- Development of the Human Visual Pathways.Brian A Wandell; Fiscal Year: 2012..g. optic neuritis or multiple sclerosis) progression, and for evaluating the efficacy of therapies.
- Functional Restoration of the Optic Nerve After Disease or DamageDong Feng Chen; Fiscal Year: 2010..of optic nerve injury to be repaired is a major feature of several blinding diseases, including glaucoma, optic neuritis, and multiple sclerosis, as well as trauma...
- PHYSIOLOGICAL ANALYSIS OF OPTIC NERVE DISEASEP King Smith; Fiscal Year: 1991..be studies include hereditary optic atrophies, toxic optic neuropathies, optic nerve compression, glaucoma and optic neuritis. The results will be correlated to the pathogenesis of the disease e.g...
- Pathogenesis of Rare Neuroimmunologic DisordersDouglas Kerr; Fiscal Year: 2004..myasthenia gravis, CIDP, transverse myelitis, TSP/HAM, stiff person syndrome, neuromyelitis optica, optic neuritis, ADEM, PANDAS, Hashimoto's encephalitis, Rasmussen's encephalitis, and paraneoplastic encephalomyelitis (PE)...
- OPTIC NEURITIS TREATMENT TRIAL--COORDINATING CENTERPatricia Cleary; Fiscal Year: 1991Following optic neuritis, virtually all patients show some signs of optic nerve damage and most are symptomatic...
- Development of an Orbital Endoscope for NeuroprotectionLouise Mawn; Fiscal Year: 2003..such as meningiomas, local application of immunosuppressive or neuroprotective agents in diseases such as optic neuritis or traumatic optic neuropathy and laser application to open the nerve sheath in pseudotumor cerebri...
- COMPUTER SYSTEM FOR PATIENT DATA-BASE MANAGEMENTAndrew Schachat; Fiscal Year: 1990..have evolved in Wilmer bearing on such eye problems as ocular melanoma, corneal transplantation, glaucoma, optic neuritis, juvenile diabetes, intraocular lens implantation, retinitis pigmentosa, the Marfan syndrome and congenital ..
- PERIMETRIC RESULTS IN THE OPTIC NEURITIS TREATMENT TRIALChris Johnson; Fiscal Year: 1993b>Optic neuritis is a common optic nerve disorder usually affecting individuals between the ages of 15 and 45. The pathogenesis is related to demyelination regardless of whether or not multiple sclerosis is present...
- ONTT COOPERATING CLINICGEORGIA CHROUSOS; Fiscal Year: 1991..for the Georgetown University Center for Sight to become one of the cooperating Clinical Centers in the Optic Neuritis Treatment Trial (ONTT)...
- ONTT COOPERATING CLINICJames Goodwin; Fiscal Year: 1991This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
- ONTT COOPERATING CLINICJonathan Trobe; Fiscal Year: 1991This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
- Novel Factors Promoting Retinal Ganglion Cell GrowthDonald Zack; Fiscal Year: 2007..or restoring vision in patients with blinding optic nerve diseases such as glaucoma, optic nerve stroke, and optic neuritis. Small molecules have potential advantages compared to larger molecules, such as proteins, in that they may be ..
- OPTIC NEURITIS TREATMENT TRIAL VISUAL FIELD READIND CTRJohn Keltner; Fiscal Year: 1992The long term objective of this research project is to serve as the Visual Field Reading Center for the Optic Neuritis Treatment Trial...
- IMMUNOCHEMICAL STUDY OF MYELINATION AND DEMYELINATIONSteven Cohen; Fiscal Year: 1980..In addition, we will determine if these properties change during a demyelinative attack. Optic neuritis patients will be followed for several years to determine if their initial CSF basic protein (30% of optic ..
- PUPILLARY AND VER INDICATORS OF OPTIC NERVE DISEASEH Thompson; Fiscal Year: 1980..Two groups of patients will be examined (a) optic neuritis, and b) ischemic optic neuropathy and the following measurements will be made: 1...
- LONGITUDINAL OPTIC NEURITIS STUDYRobin Gal; Fiscal Year: 2006This proposal is to continue a long-term follow-up study of the cohort of patients who were entered into the Optic Neuritis Treatment Trial (ONTT) between 1988 and 1991 and have been followed as part of the Longitudinal Optic Neuritis ..
- OPTIC NURITIS TREATMENT TRIALSBarrett Katz; Fiscal Year: 1991This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
- ONTT COOPERATING CLINICJOHN MC CRARY; Fiscal Year: 1991
- OPTIC NEURITIS TREATMENT TRIAL COOPERATING CLINICEdward Buckley; Fiscal Year: 1991This is an application to become one of the cooperating clinics in the optic neuritis treatment trial...
- ONTT COOPERATING CLINICWILLIAM SHULTS; Fiscal Year: 1991
- ONTT COOPERATING CLINICMichael Brodsky; Fiscal Year: 1991
- ONTT COOPERATING CLINICMark Kupersmith; Fiscal Year: 1991
- ONTT COOPERATING CLINICDavid Kaufman; Fiscal Year: 1991This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial (ONTT)...
- ONTT COOPERATING CLINICPETER SAVINO; Fiscal Year: 1992
- ONTT COOPERATING CLINICNeil Miller; Fiscal Year: 1992This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial (ONTT)...
- ONTT COOPERATING CLINICH Thompson; Fiscal Year: 1991
- PATTERN VEP--A MULTI-CENTER PILOT STUDYMitchell Brigell; Fiscal Year: 1991..PVEP has been reported to be abnormally prolonged in about 90 percent of patients with a clinical history of optic neuritis, despite a recovery of visual acuity and visual field in most patients...
- ONTT COOPERATING CLINICCraig Smith; Fiscal Year: 1991This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial (ONTT)...
- Intrinsic Molecular Control of Axon Regeneration In RGCsJeffrey Goldberg; Fiscal Year: 2007..axon growth ability, and thereby to develop new treatments to promote RGC regeneration after injury in ocular diseases including glaucoma, retinal ischemia, optic neuritis and optic neuropathies. [unreadable] [unreadable] [unreadable]
- HIGH-PERFORMANCE COILS FOR MRI STUDIES OF THE EYELINCOLN BOURNE; Fiscal Year: 1993..Potential research and clinical applications include studies of cataractogenesis, diagnosis of intraocular and orbital tumors, and high resolution imaging of optic nerve damage in glaucoma and optic neuritis.
- Mechanisms and effects of phytoestrogen treatment in autoimmune optic neuritisMARTHA STOKELY; Fiscal Year: 2008..applicant): Elevated endothelin-1 (ET-1) in the optic nerve may contribute to the pathogenesis of autoimmune optic neuritis, a common early manifestation of multiple sclerosis (MS) that can be modeled in rats with myelin ..
- Prevention of Neuronal Damage in Optic NeuritisKENNETH SHINDLER; Fiscal Year: 2008unreadable] DESCRIPTION (provided by applicant): Optic neuritis is an inflammatory optic neuropathy that occurs in association with Multiple Sclerosis (MS) in about fifty percent of patients...
- Interferon Gamma Polymorphisms and Gender Bias in MSBrian Weinshenker; Fiscal Year: 2004..If successful, this paradigm could be applied to a number of similar genetic association studies. ..
- Visual Dysfunction and Quality of Life in MSLaura Balcer; Fiscal Year: 2003..This proposal will provide a crucial foundation for future studies of vision in MS that will involve longitudinal assessment. ..
- Novel Clinical and Ocular Imaging Outcomes with Long-Term Follow-Up in MSLaura Balcer; Fiscal Year: 2010..that RNFL axonal loss over time is associated with worsening visual function, even in the absence of acute optic neuritis (ON)...
- Longitudinal Assessment of Visual Function in MSLaura Balcer; Fiscal Year: 2007....
- LIFE AND DEATH OF RETINAL GANGLION CELLSVittorio Porciatti; Fiscal Year: 2007..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..