optic neuritis

Summary

Summary: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).

Top Publications

  1. ncbi Optical coherence tomography and disease subtype in multiple sclerosis
    M Pulicken
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurology 69:2085-92. 2007
  2. ncbi Optical coherence tomography versus automated perimetry for follow-up of optic neuritis
    Susana Noval
    Department of Ophthalmology, Ramon y Cajal Hospital, Madrid, Spain
    Acta Ophthalmol Scand 84:790-4. 2006
  3. ncbi Improvement in conduction velocity after optic neuritis measured with the multifocal VEP
    E Bo Yang
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 48:692-8. 2007
  4. ncbi Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS
    Jorge Sepulcre
    Department of Neurology and Neurosurgery, University of Navarra, Pamplona, Spain
    Neurology 68:1488-94. 2007
  5. ncbi Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis
    V Pueyo
    Isabel la Catolica, Zaragoza, Spain
    Mult Scler 14:609-14. 2008
  6. ncbi NMO-IgG predicts the outcome of recurrent optic neuritis
    M Matiello
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Neurology 70:2197-200. 2008
  7. ncbi An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
  8. ncbi Correlation between morphological and functional retinal impairment in multiple sclerosis patients
    V Parisi
    Cattedra di Clinica Oculistica, Universita di Roma Tor Vergata, Italy
    Invest Ophthalmol Vis Sci 40:2520-7. 1999
  9. ncbi Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations
    Hanna Zimmermann
    NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charité Universitätsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany
    Mult Scler 19:443-50. 2013
  10. ncbi Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients
    Markus Bock
    Cecilie Vogt Clinic, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Clin Neurol Neurosurg 112:647-52. 2010

Detail Information

Publications309 found, 100 shown here

  1. ncbi Optical coherence tomography and disease subtype in multiple sclerosis
    M Pulicken
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurology 69:2085-92. 2007
    To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON).
  2. ncbi Optical coherence tomography versus automated perimetry for follow-up of optic neuritis
    Susana Noval
    Department of Ophthalmology, Ramon y Cajal Hospital, Madrid, Spain
    Acta Ophthalmol Scand 84:790-4. 2006
    To evaluate the usefulness of optical coherence tomography (OCT) for follow-up of optic neuritis (ON) compared with subjective visual function tests.
  3. ncbi Improvement in conduction velocity after optic neuritis measured with the multifocal VEP
    E Bo Yang
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 48:692-8. 2007
    To test the efficacy of the multifocal visual evoked potential (mfVEP) technique after long-term latency changes in optic neuritis (ON)/multiple sclerosis (MS), mfVEPs were recorded in 12 patients with ON/MS.
  4. ncbi Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS
    Jorge Sepulcre
    Department of Neurology and Neurosurgery, University of Navarra, Pamplona, Spain
    Neurology 68:1488-94. 2007
    ..To assess the association between the thickness of the retinal nerve fiber layer (RNFL), assessed by optical coherence tomography (OCT), retinal periphlebitis (RP), and multiple sclerosis (MS) disease activity...
  5. ncbi Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis
    V Pueyo
    Isabel la Catolica, Zaragoza, Spain
    Mult Scler 14:609-14. 2008
    To quantify axonal loss in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS), with and without a history of optic neuritis, by means of ocular imaging technologies.
  6. ncbi NMO-IgG predicts the outcome of recurrent optic neuritis
    M Matiello
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Neurology 70:2197-200. 2008
    ..determine the prognostic value of neuromyelitis optica (NMO)-immunoglobulin G (IgG) in patients with recurrent optic neuritis (ON)...
  7. ncbi An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
    ..Of the patients with secondary progressive MS, 14 had clinical history of optic neuritis (ON) in a single eye; the remaining patients had not had ON...
  8. ncbi Correlation between morphological and functional retinal impairment in multiple sclerosis patients
    V Parisi
    Cattedra di Clinica Oculistica, Universita di Roma Tor Vergata, Italy
    Invest Ophthalmol Vis Sci 40:2520-7. 1999
    To assess whether a correlation exists between optic nerve fiber layer (NFL) thickness and the retinal or visual pathway function in multiple sclerosis (MS) patients previously affected by optic neuritis.
  9. ncbi Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations
    Hanna Zimmermann
    NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charité Universitätsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany
    Mult Scler 19:443-50. 2013
    ..An influence of optic neuritis is well documented but sparsely investigated...
  10. ncbi Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients
    Markus Bock
    Cecilie Vogt Clinic, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Clin Neurol Neurosurg 112:647-52. 2010
    ..nerve fiber layer thickness (RNFLT) loss are different in MS compared to other diseases such as glaucoma and data on RNFLT loss in MS patients with or without optic neuritis (ON/NON) have remained inconsistent or even contradictory.
  11. ncbi Correlation between morphological and functional retinal impairment in patients affected by ocular hypertension, glaucoma, demyelinating optic neuritis and Alzheimer's disease
    Vincenzo Parisi
    Clinica Oculistica Università di Roma Tor Vergata, Italy
    Semin Ophthalmol 18:50-7. 2003
    ..ERG recordings) performed in patients affected by ocular hypertension (OHT), glaucoma (OAG), demyelinating optic neuritis (MSON), and Alzheimer's disease (AD) are reported...
  12. ncbi Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis
    Sven Jarius
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    J Neurol Sci 298:158-62. 2010
    ....
  13. ncbi Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
    ..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
  14. ncbi Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis
    Kevin Rostasy
    Division of Pediatric Neurology and Inherited Metabolic Disorders, Department of Pediatrics IV, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Neurol 69:752-6. 2012
    To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG)in pediatric patients with isolated and recurrent optic neuritis(ON).
  15. ncbi Optic nerve diffusion tensor imaging in optic neuritis
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 30:498-505. 2006
    ..oblique multislice (ZOOM) echoplanar imaging) was applied to 25 patients with a single unilateral episode of optic neuritis at least one year previously, and 15 controls...
  16. pmc Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus
    Kenneth S Shindler
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA
    J Neuropathol Exp Neurol 70:470-80. 2011
    ..A demyelinating MHV strain induces optic neuritis, but whether this is due to the retrograde axonal transport of viral particles to the retina or due to ..
  17. pmc Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    Estelle Bettelli
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 197:1073-81. 2003
    ..an autoimmune disease of the central nervous system (CNS) that in many patients first presents clinically as optic neuritis. The relationship of optic neuritis to MS is not well understood...
  18. ncbi Long-term remyelination after optic neuritis: A 2-year visual evoked potential and psychophysical serial study
    A Brusa
    Department of Clinical Neurophysiology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 124:468-79. 2001
    ..at 3-month intervals for the first year and at 6-month intervals for the second year, after an episode of optic neuritis. The object was to confirm previous evidence for a progressive shortening of visual evoked potential (VEP) ..
  19. ncbi Electrophysiological evidence for heterogeneity of lesions in optic neuritis
    Alexander Klistorner
    Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
    Invest Ophthalmol Vis Sci 48:4549-56. 2007
    To examine the natural history of multifocal visual evoked potentials (mfVEPs) within 12 months of the first episode of optic neuritis (ON) in patients with possible multiple sclerosis (MS).
  20. pmc Optical coherence tomography: a window into the mechanisms of multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Nat Clin Pract Neurol 4:664-75. 2008
    ....
  21. ncbi Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis
    Scott Kolbe
    The Howard Florey Institute, University of Melbourne, Melbourne, Australia
    Neuroimage 45:679-86. 2009
    ..b>Optic neuritis, a condition characterised by inflammatory demyelination of the optic nerve, is one of the commonest sites of ..
  22. ncbi Demyelination affects temporal aspects of perception: an optic neuritis study
    Noa Raz
    The Agnes Ginges Center for Human Neurogenetics, Laboratory for Neuroimmunology, The Department of Neurology, Jerusalem, Israel
    Ann Neurol 71:531-8. 2012
    Visual Evoked Potentials (VEPs) following optic neuritis (ON) remain chronically prolonged, although standard visual tests indicate full recovery...
  23. ncbi Chromatic discrimination losses in multiple sclerosis patients with and without optic neuritis using the Cambridge Colour Test
    Ana Laura de Araújo Moura
    Depto Psicologia Experimental, Instituto de Psicologia, Universidade de Sao Paulo, Sao Paulo, Brasil
    Vis Neurosci 25:463-8. 2008
    ..chromatic discrimination in multiple sclerosis (MS) patients both with (ON) and without (no ON) a history of optic neuritis using the Cambridge color test (CCT)...
  24. ncbi Clinical application of the multifocal VEPs
    Y Betsuin
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Curr Eye Res 22:54-63. 2001
    ..CONCLUSIONS: Multifocal VEPs summed within four quadrants can be used for an objective evaluation of the visual fields. The testing can be obtained in 4 min with no pain or discomfort to the patient...
  25. ncbi Recovery from optic neuritis: an ROI-based analysis of LGN and visual cortical areas
    Kirsten Korsholm
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, 2650 Hvidovre, Denmark
    Brain 130:1244-53. 2007
    b>Optic neuritis (ON) is the first clinical manifestation in approximately 20% of patients with multiple sclerosis (MS)...
  26. pmc Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus
    Kenneth S Shindler
    FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 82:8882-6. 2008
    b>Optic neuritis (ON), an inflammatory demyelinating optic nerve disease, occurs in multiple sclerosis (MS). Pathological mechanisms and potential treatments for ON have been studied via experimental autoimmune MS models...
  27. pmc Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivities
    R T Naismith
    Department of Neurology, Washington University, Saint Louis, MO, USA
    Neurology 72:589-94. 2009
    ..the potential of directional diffusivities from diffusion tensor imaging (DTI) to predict clinical outcome of optic neuritis (ON), and correlate with vision, optical coherence tomography (OCT), and visual evoked potentials (VEP).
  28. pmc Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis
    Stephanie B Syc
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain 135:521-33. 2012
    ..in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal layers following acute optic neuritis remains largely unexplored...
  29. pmc Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry
    Theodora A M Siepman
    Department of Neurology, MS Centre ErasMS, Erasmus MC, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    J Neurol 257:1654-60. 2010
    ..Twenty-eight patients (43%) had a history of optic neuritis (ON). Adjustments were made for age and disease duration...
  30. ncbi Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis
    L K Fisniku
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Brain 131:808-17. 2008
    Clinically isolated syndromes (CIS), such as optic neuritis, brainstem or spinal cord syndromes are frequently the first clinical presentations of multiple sclerosis...
  31. ncbi Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis
    Bertrand Audoin
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Brain 129:1031-9. 2006
    ..analysis of GM MTR maps in a group of 80 patients studied within 6 months of presenting with isolated optic neuritis and compared the findings with those seen in 50 age- and sex-matched healthy controls...
  32. ncbi Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group
    L D Jacobs
    Department of Neurology, State University of New York School of Medicine at Buffalo and Buffalo General Hospital, 14203, USA
    N Engl J Med 343:898-904. 2000
    ..Treatment with interferon beta has been shown to help patients with established multiple sclerosis, but it is not known whether initiating treatment at the time of a first clinical demyelinating event is of value...
  33. ncbi Evolving management of optic neuritis and multiple sclerosis
    Anthony C Arnold
    Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90095 7005, USA
    Am J Ophthalmol 139:1101-8. 2005
    To review the relation of optic neuritis to multiple sclerosis (MS) and the indications, modalities, and results of therapy for optic neuritis, for both visual and general neurologic function.
  34. pmc Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis
    Kenneth S Shindler
    Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104 6100, United States
    Exp Eye Res 87:208-13. 2008
    b>Optic neuritis is an inflammatory disease of the optic nerve that often occurs in patients with multiple sclerosis and leads to permanent visual loss mediated by retinal ganglion cell (RGC) damage...
  35. pmc SIRT1 activation confers neuroprotection in experimental optic neuritis
    Kenneth S Shindler
    F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 48:3602-9. 2007
    ..damage and loss of neurons correlate with permanent vision loss and neurologic disability in patients with optic neuritis and multiple sclerosis (MS)...
  36. ncbi Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography
    F Costello
    Department of Clinical Neurosciences and Ophthalmology, The University of Calgary and Hotchkiss Brain Institute, Calgary, Alberta, Canada
    Mult Scler 14:893-905. 2008
    b>Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography...
  37. ncbi Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis
    J Toledo
    Department of Neurology and Neurosurgery, Clinica Universitaria de Navarra and Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Mult Scler 14:906-12. 2008
    ....
  38. ncbi Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis
    Simon J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    AJNR Am J Neuroradiol 26:951-6. 2005
    ..DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging.
  39. ncbi Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis
    A Petzold
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:109-11. 2010
    The clinical course of immune mediated optic neuritis (ON) will depend on the specific underlying inflammatory disease. These disorders have traditionally been classified according to clinical and MRI findings...
  40. ncbi Transient raise of endothelin-1 plasma level and reduction of ocular blood flow in a patient with optic neuritis
    Timo Haufschild
    University Eye Clinic, Basel, Switzerland
    Ophthalmologica 217:451-3. 2003
    To analyze how far an ischemic component might have been involved in optic neuritis.
  41. ncbi Fellow eye changes in optic neuritis correlate with the risk of multiple sclerosis
    A Klistorner
    Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
    Mult Scler 15:928-32. 2009
    ..The clinically unaffected (fellow) eye of patients with unilateral optic neuritis (ON) may reflect the status of normal-appearing white matter in the CNS, which can be assessed ..
  42. ncbi Distinctive retinal nerve fibre layer and vascular changes in neuromyelitis optica following optic neuritis
    A J Green
    Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
    J Neurol Neurosurg Psychiatry 80:1002-5. 2009
    This is a cross sectional study comparing the retinal features of optic neuritis (ON) between 20 multiple sclerosis (MS) and 16 neuromyelitis optica (NMO) patients with a history of ON (visual acuity at time of attack >20/100) matched ..
  43. ncbi Lyme optic neuritis
    Frederic Blanc
    Department of Neurology, University Hospital of Strasbourg, Strasbourg, France
    J Neurol Sci 295:117-9. 2010
    Lyme optic neuritis (ON) is a rare disease and only a few cases have been reported. We describe two cases of isolated Lyme ON, one with recurrence 9 months after the appearance of initial symptoms...
  44. ncbi An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis
    Katharina Hein
    Department of Neurology, Georg August University, Gottingen, Germany
    Invest Ophthalmol Vis Sci 53:157-63. 2012
    ..was to evaluate the ability and accuracy of spectral domain optical coherence tomography (OCT) for in vivo monitoring of retinal ganglion cell degeneration in a rat model of myelin oligodendrocyte glycoprotein-induced optic neuritis.
  45. ncbi Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis
    Scott C Kolbe
    Department of Physiology, Monash University, Clayton, Vic, 3800, Australia
    Invest Ophthalmol Vis Sci 53:825-32. 2012
    To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON).
  46. ncbi Latency delay of visual evoked potential is a real measurement of demyelination in a rat model of optic neuritis
    Yuyi You
    Department of Ophthalmology, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
    Invest Ophthalmol Vis Sci 52:6911-8. 2011
    ..To investigate the relationship between size of demyelinated lesion, extent of axonal loss, and degree of latency delay of visual evoked potentials (VEPs) in a rat model of experimental demyelination...
  47. ncbi Clinical practice. Optic neuritis
    Laura J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 354:1273-80. 2006
  48. pmc Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes
    Jeffrey M Gelfand
    University of California, San Francisco Department of Neurology, Multiple Sclerosis Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e36847. 2012
    ....
  49. ncbi Treatment of optic neuritis by plasma exchange (add-on) in neuromyelitis optica
    Harold Merle
    Service d Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Hopital Pierre Zobda Quitman, Martinique, France
    Arch Ophthalmol 130:858-62. 2012
    To assess the contribution of plasma exchange (PE) in association (add-on) with pulsed intravenous corticosteroids in acute optic neuritis of neuromyelitis optica (NMO) and limited forms of NMO.
  50. ncbi Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysis
    Y Jin
    Neuroepidemiology Unit, Karolinska Institute, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    J Neurol Sci 181:56-64. 2000
    To quantify and characterize seasonal variation in monosymptomatic optic neuritis (MON) onsets, multiple sclerosis (MS) onsets and MS exacerbations (MSE), a meta-analysis was performed, using established methods and pooling weighted ..
  51. ncbi Visual resting-state network in relapsing-remitting MS with and without previous optic neuritis
    Antonio Gallo
    Department of Neurological Sciences, Second University of Naples, Naples, Italy
    Neurology 79:1458-65. 2012
    To investigate functional connectivity of the visual resting-state network (V-RSN) in normal-sighted relapsing-remitting multiple sclerosis (RRMS) patients with and without previous optic neuritis (ON).
  52. ncbi Remyelination of optic nerve lesions: spatial and temporal factors
    Alexandr Klistorner
    Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
    Mult Scler 16:786-95. 2010
    b>Optic neuritis provides an in vivo model to study demyelination. The effects of myelin loss and recovery can be measured by the latency of the multifocal visual evoked potentials...
  53. ncbi Interferon beta-1a for early multiple sclerosis: CHAMPS trial subgroup analyses
    roy W Beck
    CHAMPS Analysis Center, Jaeb Center for Health Research, Tampa, FL 33613, USA
    Ann Neurol 51:481-90. 2002
    ..Adjusted rate ratios for the development of clinically definite multiple sclerosis in the optic neuritis, brainstem-cerebellar, and spinal cord syndrome subgroups were 0.58 (p = 0.05), 0.40 (p = 0.03), and 0...
  54. pmc Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats
    Arabinda Das
    Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Neurochem 124:133-46. 2013
    b>Optic neuritis (ON), which is an acute inflammatory autoimmune demyelinating disease of the central nervous system (CNS), often occurs in multiple sclerosis (MS)...
  55. ncbi Optic neuritis and risk of MS: differential diagnosis and management
    Benjamin J Osborne
    Departments of Neurology and Ophthalmology, Georgetown University Medical Center, Washington, DC, USA
    Cleve Clin J Med 76:181-90. 2009
    b>Optic neuritis, a cause of sudden vision loss, often heralds the onset of multiple sclerosis (MS) within the next few years...
  56. ncbi Dissecting structure-function interactions in acute optic neuritis to investigate neuroplasticity
    Thomas Jenkins
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Hum Brain Mapp 31:276-86. 2010
    ..We combined them to investigate why patients with optic neuritis (ON) exhibit a wide variation in severity of acute visual loss, with the following objectives: (1) To ..
  57. ncbi Cortical neuroplasticity in patients recovering from acute optic neuritis
    Kirsten Korsholm
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark
    Neuroimage 42:836-44. 2008
    Patients with optic neuritis (ON) undergo cortical and subcortical neuroplasticity as revealed by functional magnetic resonance imaging (fMRI)...
  58. ncbi Systemic lupus erythematosus-associated optic neuritis: clinical experience and literature review
    Yen Ching Lin
    Department of Ophthalmology, Suao Veterans Hospital, I Lan, Taiwan
    Acta Ophthalmol 87:204-10. 2009
    This study aimed to evaluate the visual outcome of optic neuritis in patients with systemic lupus erythematosus (SLE).
  59. ncbi Normal and abnormal fMRI activation patterns in the visual cortex after recovery from optic neuritis
    Netta Levin
    Department of Neurobiology, Hebrew University, Jerusalem, Israel
    Neuroimage 33:1161-8. 2006
    Recovery to normal or near normal visual acuity after an optic neuritis episode is common, despite frequent persistence of conduction abnormalities, evident in prolonged visual evoked potential (VEP) latencies...
  60. ncbi Using retinal architecture to help characterize multiple sclerosis patients
    Fiona Costello
    Departments of Clinical Neurosciences and Surgery, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta
    Can J Ophthalmol 45:520-6. 2010
    ....
  61. ncbi MRI demonstrates restricted diffusion in distal optic nerve in atypical optic neuritis
    Oriel Spierer
    Ophthalmology Department, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    J Neuroophthalmol 30:31-3. 2010
    ..The presence of restricted diffusion is helpful in excluding a neoplastic cause of a thickened optic nerve...
  62. pmc Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis
    Amena W Smith
    Departments of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 52:4935-41. 2011
    b>Optic neuritis (ON), inflammation of the optic nerve, is strongly associated with the pathogenesis of multiple sclerosis (MS) and is initiated by the attack of autoreactive T cells against self-myelin antigens, resulting in demyelination, ..
  63. pmc Optic neuritis
    D Pau
    Department of Ophthalmology, The Methodist Hospital, Houston, TX 77030, USA
    Eye (Lond) 25:833-42. 2011
    The aim of this study is to provide a clinical update on optic neuritis (ON), its association with multiple sclerosis (MS), and neuromyelitis optica (NMO).
  64. ncbi Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy
    Xiaoping Qi
    Department of Ophthalmology, University of Florida, College of Medicine, Gainesville, FL 32610 0284, USA
    Invest Ophthalmol Vis Sci 48:5360-70. 2007
    To test in mice with experimental autoimmune encephalomyelitis (EAE) a strategy designed to treat patients at risk for axonal degeneration and persistent visual loss from optic neuritis and multiple sclerosis.
  65. ncbi Independent patterns of damage to retinocortical pathways in multiple sclerosis without a previous episode of optic neuritis
    Aldina Reis
    Faculty of Medicine, Visual Neuroscience Laboratory, Institute of Biomedical Research on Light and Image IBILI, University of Coimbra, Azinhaga de Santa Comba, Celas, 3000 548 Coimbra, Portugal
    J Neurol 258:1695-704. 2011
    ..patterns of subclinical visual impairment in patients with MS with and without clinically associated previous optic neuritis (ON)...
  66. ncbi Magnetisation transfer ratio in optic neuritis is associated with axonal loss, but not with demyelination
    A Klistorner
    Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
    Neuroimage 56:21-6. 2011
    ..mfVEP) (measure of optic nerve conduction) and Retinal Nerve Fiber Layer (RNFL) thickness (measure of axonal damage) we investigated the effect of neurodegeneration and demyelination on MTR after an episode of optic neuritis (ON).
  67. ncbi Comparison of retinal nerve fiber layer and central macular thickness measurements among five different optical coherence tomography instruments in patients with multiple sclerosis and optic neuritis
    George M Watson
    Department of Ophthalmology and Vision Science, University of California Davis Eye Center, Sacramento, California 95817, USA
    J Neuroophthalmol 31:110-6. 2011
    ..the mean average optic nerve retinal nerve fiber layer (RNFL) thickness in the eyes of patients with a history of optic neuritis and/or multiple sclerosis (MS) using 5 commercially available optical coherence tomography (OCT) instruments.
  68. ncbi Quantifying axonal loss after optic neuritis with optical coherence tomography
    Fiona Costello
    Division of Neurology, Ottawa, Ontario Canada
    Ann Neurol 59:963-9. 2006
    To determine to what degree changes in retinal nerve fiber layer (RNFL) thickness after optic neuritis (ON) correlate with either visual recovery or impairment.
  69. ncbi Optic neuritis is nothing to sneeze at
    Michael S Vaphiades
    Departments of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Surv Ophthalmol 52:106-10. 2007
    A 36-year-old man developed acute visual loss, mimicking an optic neuritis in the left eye...
  70. ncbi Sustained motion perception deficit following optic neuritis: Behavioral and cortical evidence
    N Raz
    Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Neurology 76:2103-11. 2011
    To assess the recovery process in patients after an acute optic neuritis (ON) attack, comparing static and dynamic visual functions.
  71. pmc Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis
    Hideto Nakajima
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan
    BMC Neurol 10:45. 2010
    ..Central scotoma is recognized as a characteristic visual field defect pattern of optic neuritis (ON), however, the differing pathogenic mechanisms of NMO and MS may result in different patterns of visual ..
  72. ncbi A case of secondary syphilis presenting as optic neuritis
    Monica Bandettini di Poggio
    Department of Neurology, Ophthalmology and Genetics, San Martino Hospital, University of Genoa, Via De Toni 5, 16132, Genoa, Italy
    Neurol Sci 31:365-7. 2010
    ..We also support the view that the presence of ocular involvement in syphilitic patients is suggestive of involvement of the CNS and should be considered synonymous with neurosyphilis...
  73. ncbi Management of acute optic neuritis
    S J Hickman
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    Lancet 360:1953-62. 2002
    b>Optic neuritis is a common condition that causes reversible loss of vision. It can be clinically isolated or can arise as one of the manifestations of multiple sclerosis...
  74. ncbi Optical coherence tomography of the retina: applications in neurology
    Panitha Jindahra
    The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Curr Opin Neurol 23:16-23. 2010
    ..The application of optical coherence tomography imaging of the retina in multiple sclerosis, neuromyelitis optica, Alzheimer disease, and Parkinson disease are reviewed...
  75. pmc Heterogeneous pattern of retinal nerve fiber layer in multiple sclerosis. High resolution optical coherence tomography: potential and limitations
    Nermin Serbecic
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    PLoS ONE 5:e13877. 2010
    ..of RNFL be detected in all MS patients, even in early disease courses and in all MS subtypes? (3) Does an optic neuritis (ON) or focal lesions along the visual pathways, which are both very common in MS, limit the predication of ..
  76. ncbi Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2
    Mandana Zandian
    Department of Surgery, Cedars Sinai Burns and Allen Research Institute, Center for Neurobiology and Vaccine Development, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 50:3275-82. 2009
    ..The present study was conducted to determine whether the ocular infection with this recombinant virus induces optic neuritis independent of virus dose, major histocompatibility complex (MHC) background, or sex.
  77. ncbi Multifocal VEP and OCT in optic neuritis: a topographical study of the structure-function relationship
    Alexander Klistorner
    Department of Ophthalmology, Save Sight Institute, University of Sydney, P O Box 4337, Sydney, NSW 2001, Australia
    Doc Ophthalmol 118:129-37. 2009
    To investigate topographical relationship between amplitude of multifocal visual evoked potentials (mfVEP) and retinal nerve fibre layer (RNFL) thickness following acute optic neuritis (ON).
  78. ncbi Isolated optic neuritis from an identified Gnathostoma spinigerum
    W Chuenkongkaew
    Department of Ophthalmology, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand
    Eur J Ophthalmol 17:130-2. 2007
    To describe a patient with isolated monocular optic neuritis caused by an identified Gnathostoma spinigerum infestation.
  79. ncbi Correlation between optic disc atrophy and aetiology: anterior ischaemic optic neuropathy vs optic neuritis
    E Z Rath
    Department of Ophthalmology, Western Galilee Medical Center, Nahariya, Israel
    Eye (Lond) 17:1019-24. 2003
    The morphologic features of swollen disc in the acute stage of optic neuritis and anterior ischaemic optic neuropathy (AION) have been extensively investigated in contrast to the morphologic features of optic disc atrophy after these ..
  80. ncbi Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57BL/6 mouse
    Hui Shao
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 45:4060-5. 2004
    ..To determine the relationship between optic neuritis (ON) and EAE, we examined the incidence of ON in C57BL/6 (B6) mice immunized with a myelin oligodendrocyte/..
  81. ncbi Optic disc cupping after optic neuritis evaluated with optic coherence tomography
    G Rebolleda
    Ophthalmology Department, Glaucoma Unit, Hospital Ramon y Cajal, Madrid, Spain
    Eye (Lond) 23:890-4. 2009
    To determine whether the optic disc experiences cupping after an episode of optic neuritis as assessed by optical coherence tomography (OCT).
  82. ncbi Visual function at baseline and 1 month in acute optic neuritis: predictors of visual outcome
    M J Kupersmith
    Neuro Ophthalmology, INN at Roosevelt Hospital and Albert Einstein School of Medicine, New York, NY 10019, USA
    Neurology 69:508-14. 2007
    ..criteria in a clinical trial to test potential neuroprotection or myelin repair agents in patients with optic neuritis. To determine whether moderate-to-severe dysfunction in one or more visual measures at baseline or 1 month ..
  83. ncbi Optic neuritis in adults and children
    Jeffrey A Boomer
    Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma School of Medicine, Oklahoma City, OK 73104, USA
    Semin Ophthalmol 18:174-80. 2003
    Most ophthalmologists will encounter optic neuritis in the course of their practice. The disease behaves very differently in children versus adults...
  84. ncbi Adaptive cortical plasticity in higher visual areas after acute optic neuritis
    Ahmed T Toosy
    Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 57:622-33. 2005
    ..applying visual functional magnetic resonance imaging (fMRI) and optic nerve MRI to 20 patients with acute optic neuritis at baseline, 1, 3, 6, and 12 months...
  85. ncbi The presentation, aetiology, management and outcome of optic neuritis in an Asian population
    J C Wang
    Singapore National Eye Centre, Singapore
    Clin Experiment Ophthalmol 29:312-5. 2001
    To analyse the presentation, aetiology, management and outcome of patients with optic neuritis (ON) in Singapore.
  86. ncbi Low conversion rate to multiple sclerosis in idiopathic optic neuritis patients in Taiwan
    Yen Ching Lin
    Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    Jpn J Ophthalmol 50:170-5. 2006
    To investigate the clinical characteristics of patients with idiopathic optic neuritis (ON) in Taiwan and to assess the conversion rate to multiple sclerosis (MS) in these patients.
  87. ncbi Axonal loss and myelin in early ON loss in postacute optic neuritis
    Alexander Klistorner
    Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia
    Ann Neurol 64:325-31. 2008
    ..the relation between retinal nerve fiber layer (RNFL) thickness and latency and amplitude of multifocal visual-evoked potentials (mfVEPs) in the postacute stage of optic neuritis in patients with early or possible multiple sclerosis.
  88. ncbi Acute axonal damage predicts clinical outcome in patients with multiple sclerosis
    E T Lim
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Mult Scler 11:532-6. 2005
    ..fluid (CSF) neurofilament heavy chain (NfH(SM134) and NfH(SM135)) levels relate to clinical outcome in optic neuritis (ON) and multiple sclerosis (MS) relapse patients treated with high dose oral methylprednisolone; and (2) to ..
  89. ncbi Differences in retinal nerve fiber layer atrophy between multiple sclerosis subtypes
    Fiona Costello
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    J Neurol Sci 281:74-9. 2009
    ..To determine whether retinal nerve fiber layer (RNFL) atrophy in the afferent visual pathway may complement existing tools used to describe and characterize differences across MS subtypes...
  90. pmc Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patients
    Michal Laron
    University of Houston, College of Optometry, Houston, Texas 77204 2020, USA
    Mult Scler 16:412-26. 2010
    ..Multifocal visual evoked potentials (mfVEP) measure local response amplitude and latency in the field of vision...
  91. ncbi Optic radiation changes after optic neuritis detected by tractography-based group mapping
    Olga Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Hum Brain Mapp 25:308-16. 2005
    ..This study investigated in vivo the optic radiations in patients affected by optic neuritis using fast marching tractography (FMT), a diffusion magnetic resonance imaging (MRI) fiber tracking method, ..
  92. ncbi Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis
    Madhan Kolappan
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    J Neurol 256:305-19. 2009
    ..Retinal nerve fibre layer (RNFL) thickness is usually reduced following an episode of optic neuritis. Techniques such as optical coherence tomography, scanning laser polarimetry, and confocal scanning laser ..
  93. ncbi Plasma exchange for severe optic neuritis: treatment of 10 patients
    K Ruprecht
    Clinical Research Unit for Multiple Sclerosis and Neuroimmunology, Julius Maximilians University, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neurology 63:1081-3. 2004
    The authors reviewed a series of 10 consecutive patients treated with plasma exchange (PE) for acute, severe optic neuritis (ON) largely unresponsive to previous high-dose IV glucocorticosteroids...
  94. pmc Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice
    Grazyna Adamus
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 53:406-12. 2012
    b>Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal injury in the optic nerve and leads to apoptotic retinal ganglion cell (RGC) death, which contributes to the persistence of visual loss...
  95. ncbi Early factors associated with axonal loss after optic neuritis
    Andrew P D Henderson
    NMR Research Unit, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 70:955-63. 2011
    Acute optic neuritis due to an inflammatory demyelinating lesion of the optic nerve is often seen in association with multiple sclerosis...
  96. ncbi Predicting the outcome of optic neuritis: evaluation of risk factors after 30 years of follow-up
    Petra Nilsson
    Department of Neurology, University Hospital, 22185 Lund, Sweden
    J Neurol 252:396-402. 2005
    Multiple sclerosis (MS) is a common disease with considerable risk for disability. Optic neuritis (ON) is a common first symptom of MS but it can also remain an isolated episode...
  97. ncbi Retinal nerve fiber layer thickness and spatial and temporal contrast sensitivity in multiple sclerosis
    Harold Merle
    Service d Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Martinique, France
    Eur J Ophthalmol 20:158-66. 2010
    ..To measure peripapillary retinal nerve fiber layer (RNFL) thickness and spatial and temporal contrast sensitivity in multiple sclerosis (MS) taking into account previous history of optic neuropathy (ON)...
  98. ncbi Tracking the recovery of local optic nerve function after optic neuritis: a multifocal VEP study
    D C Hood
    Department of Psychology, Columbia University, College of Physicians and Surgeons, New York, New York
    Invest Ophthalmol Vis Sci 41:4032-8. 2000
    To explore the multifocal visual evoked potential (mVEP) as a technique for tracking local optic nerve damage after unilateral optic neuritis (ON).
  99. ncbi Bilateral optic neuritis and Guillain-Barré syndrome following an acute Mycoplasma pneumoniae infection
    Ricardo C Ginestal
    J Neurol 251:767-8. 2004

Research Grants62

  1. CNS Demyelinating Autoimmunity Targeting Water Channel Complexes
    SEAN JOSEPH PITTOCK; Fiscal Year: 2013
    ..It is characterized by recurrent episodes of optic neuritis and transverse myelitis, resulting in blindness and paraplegia in most patients, and it is frequently ..
  2. Novel Mitochondrial Targeted Neuroprotectants for Glaucoma
    Leonard Levin; Fiscal Year: 2009
    ..treatment, including ischemic optic neuropathy (the most common acute optic neuropathy of the elderly), optic neuritis (the most common acute optic neuropathy of the young), and many others...
  3. Experimental Optic Neuritis: Gene Therapy
    John Guy; Fiscal Year: 2011
    ..Moreover, the mechanisms leading to neurodegeneration in optic neuritis and MS are poorly understood...
  4. Mechanism of SIRT1 activator mediated neuroprotection of retinal ganglion cells
    Kenneth S Shindler; Fiscal Year: 2013
    b>Optic neuritis is an inflammatory demyelinating disease of the optic nerve that occurs in association with the central nervous system (CNS) demyelinating disease multiple sclerosis (MS) and leads to permanent visual loss in up to 40% of ..
  5. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2013
    ..of glaucoma, the ND4 transgenic mouse of multiple sclerosis, and the MOG-specific TCR transgenic mouse of optic neuritis. Controls will be corresponding non-pathological congenic mice...
  6. Aquaporin-4 in NMO Optic Neuritis: Pathogenesis and New Therapies
    Alan S Verkman; Fiscal Year: 2013
    ..an autoimmune, inflammatory demyelinating disease primarily affecting optic nerve and spinal cord, producing optic neuritis and blindness. A defining feature of NMO is the presence of serum autoantibodies (NMO-IgG) against AQP4...
  7. Interaction of Isl1 and Pou4f2 in retinal development
    Xiuqian Mu; Fiscal Year: 2013
    ..we will also obtain valuable information on why they die under certain disease conditions, such as glaucoma, optic neuritis, and ischemic optic neuropathy, and thus be able to develop novel preventive and therapeutic strategies for ..
  8. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2010
    ..3. Determine if a recombinant HSV-1 expressing IL-4 (HSV-IL-4) can protect against HSV-IL-2-induced demyelination, while a similarly made recombinant virus expressing IFN-gamma is not beneficial. ..
  9. Protein kinase inhibitors that promote RGC survival and function
    Donald J Zack; Fiscal Year: 2010
    ..their axons in optic nerves are frequently targeted in a variety of degenerative disorders such as glaucoma, optic neuritis, anterior ischemic optic neuropathy, and traumatic compression of optic nerves...
  10. Development of visual and neurologic outcome measures in pediatric MS
    AMY TARA WALDMAN; Fiscal Year: 2013
    ..visual and neurologic function reflect axonal and neuronal loss as captured by OCT, adjusting for a history of optic neuritis. Specific Aim 3 - Validate the presence or absence of axonal loss as measured by OCT using other ..
  11. Administrative Supplements for Research on Sex/Gender Differences(admin supp)
    Peter Koulen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Degeneration or damage of the optic nerve and the retina due to optic neuritis is a leading cause of visual loss and blindness in the United States and worldwide associated with multiple sclerosis and ..
  12. DEVELOPMENTAL CONTROL OF AXON REGENERATION IN RGCs
    Jeffrey L Goldberg; Fiscal Year: 2010
    ..treatments to promote RGC regeneration after injury in ocular diseases including glaucoma, retinal ischemia, optic neuritis and optic neuropathies, and to extend our understanding to more broadly promote CMS regeneration, for example ..
  13. Multi-Modality, Quantitative MRI to Assess the Human Optic Nerve in vivo
    Seth A Smith; Fiscal Year: 2013
    b>Optic Neuritis, marked by idiopathic, sudden inflammation of the optic nerve (ON), is the most commonly presenting symptom of MS...
  14. 2nd International Pathogenesis of Rare Neuroimmunologic Disorders
    Douglas Kerr; Fiscal Year: 2006
    ..myelitis, HTLV-1 associated myelopathy, stiff person syndrome[unreadable] (SPS), neuromyelitis optica (NMO), optic neuritis (ON), multiple sclerosis (MS), acute disseminated[unreadable] encephalomyelitis (ADEM), Hashimoto?s ..
  15. Role of Calpain in the Pathogenesis of Experimental Optic Neuritis
    AMENA WESTON SMITH; Fiscal Year: 2011
    b>Optic neuritis (ON), inflammation of the optic nerve, is due to influx of autoreactive T cells and other immune cells...
  16. OPTIC NERVE MYELINATION
    Ben A Barres; Fiscal Year: 2012
    ..how myelination is regulated may suggest new ways of enhancing remyelination after injury or diseases such as optic neuritis and Multiple Sclerosis...
  17. Kruppel-like Transcription Factors in Retinal Ganglion Cell Regeneration
    Jeffrey L Goldberg; Fiscal Year: 2013
    ..treatments to promote RGC regeneration after injury in ocular diseases including glaucoma, retinal ischemia, optic neuritis and optic neuropathies, and to extend our understanding to more broadly promote CNS regeneration, for example ..
  18. Manipulating retinal progenitor cells
    William H Klein; Fiscal Year: 2010
    ..of retinal development as well as establishing new approaches to regenerate damaged retinas and prevent or repair optic nerve degeneration in retinal pathologies such as optic neuritis, ischemic optic neuropathy, and glaucoma.
  19. Development of the Human Visual Pathways.
    Brian A Wandell; Fiscal Year: 2012
    ..g. optic neuritis or multiple sclerosis) progression, and for evaluating the efficacy of therapies.
  20. Functional Restoration of the Optic Nerve After Disease or Damage
    Dong Feng Chen; Fiscal Year: 2010
    ..of optic nerve injury to be repaired is a major feature of several blinding diseases, including glaucoma, optic neuritis, and multiple sclerosis, as well as trauma...
  21. PHYSIOLOGICAL ANALYSIS OF OPTIC NERVE DISEASE
    P King Smith; Fiscal Year: 1991
    ..be studies include hereditary optic atrophies, toxic optic neuropathies, optic nerve compression, glaucoma and optic neuritis. The results will be correlated to the pathogenesis of the disease e.g...
  22. Pathogenesis of Rare Neuroimmunologic Disorders
    Douglas Kerr; Fiscal Year: 2004
    ..myasthenia gravis, CIDP, transverse myelitis, TSP/HAM, stiff person syndrome, neuromyelitis optica, optic neuritis, ADEM, PANDAS, Hashimoto's encephalitis, Rasmussen's encephalitis, and paraneoplastic encephalomyelitis (PE)...
  23. OPTIC NEURITIS TREATMENT TRIAL--COORDINATING CENTER
    Patricia Cleary; Fiscal Year: 1991
    Following optic neuritis, virtually all patients show some signs of optic nerve damage and most are symptomatic...
  24. Development of an Orbital Endoscope for Neuroprotection
    Louise Mawn; Fiscal Year: 2003
    ..such as meningiomas, local application of immunosuppressive or neuroprotective agents in diseases such as optic neuritis or traumatic optic neuropathy and laser application to open the nerve sheath in pseudotumor cerebri...
  25. COMPUTER SYSTEM FOR PATIENT DATA-BASE MANAGEMENT
    Andrew Schachat; Fiscal Year: 1990
    ..have evolved in Wilmer bearing on such eye problems as ocular melanoma, corneal transplantation, glaucoma, optic neuritis, juvenile diabetes, intraocular lens implantation, retinitis pigmentosa, the Marfan syndrome and congenital ..
  26. PERIMETRIC RESULTS IN THE OPTIC NEURITIS TREATMENT TRIAL
    Chris Johnson; Fiscal Year: 1993
    b>Optic neuritis is a common optic nerve disorder usually affecting individuals between the ages of 15 and 45. The pathogenesis is related to demyelination regardless of whether or not multiple sclerosis is present...
  27. ONTT COOPERATING CLINIC
    GEORGIA CHROUSOS; Fiscal Year: 1991
    ..for the Georgetown University Center for Sight to become one of the cooperating Clinical Centers in the Optic Neuritis Treatment Trial (ONTT)...
  28. ONTT COOPERATING CLINIC
    James Goodwin; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  29. ONTT COOPERATING CLINIC
    Jonathan Trobe; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  30. Novel Factors Promoting Retinal Ganglion Cell Growth
    Donald Zack; Fiscal Year: 2007
    ..or restoring vision in patients with blinding optic nerve diseases such as glaucoma, optic nerve stroke, and optic neuritis. Small molecules have potential advantages compared to larger molecules, such as proteins, in that they may be ..
  31. OPTIC NEURITIS TREATMENT TRIAL VISUAL FIELD READIND CTR
    John Keltner; Fiscal Year: 1992
    The long term objective of this research project is to serve as the Visual Field Reading Center for the Optic Neuritis Treatment Trial...
  32. IMMUNOCHEMICAL STUDY OF MYELINATION AND DEMYELINATION
    Steven Cohen; Fiscal Year: 1980
    ..In addition, we will determine if these properties change during a demyelinative attack. Optic neuritis patients will be followed for several years to determine if their initial CSF basic protein (30% of optic ..
  33. PUPILLARY AND VER INDICATORS OF OPTIC NERVE DISEASE
    H Thompson; Fiscal Year: 1980
    ..Two groups of patients will be examined (a) optic neuritis, and b) ischemic optic neuropathy and the following measurements will be made: 1...
  34. LONGITUDINAL OPTIC NEURITIS STUDY
    Robin Gal; Fiscal Year: 2006
    This proposal is to continue a long-term follow-up study of the cohort of patients who were entered into the Optic Neuritis Treatment Trial (ONTT) between 1988 and 1991 and have been followed as part of the Longitudinal Optic Neuritis ..
  35. OPTIC NURITIS TREATMENT TRIALS
    Barrett Katz; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  36. ONTT COOPERATING CLINIC
    JOHN MC CRARY; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  37. OPTIC NEURITIS TREATMENT TRIAL COOPERATING CLINIC
    Edward Buckley; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the optic neuritis treatment trial...
  38. ONTT COOPERATING CLINIC
    WILLIAM SHULTS; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  39. ONTT COOPERATING CLINIC
    Michael Brodsky; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  40. ONTT COOPERATING CLINIC
    Mark Kupersmith; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  41. ONTT COOPERATING CLINIC
    David Kaufman; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial (ONTT)...
  42. ONTT COOPERATING CLINIC
    PETER SAVINO; Fiscal Year: 1992
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  43. ONTT COOPERATING CLINIC
    Neil Miller; Fiscal Year: 1992
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial (ONTT)...
  44. ONTT COOPERATING CLINIC
    H Thompson; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial...
  45. PATTERN VEP--A MULTI-CENTER PILOT STUDY
    Mitchell Brigell; Fiscal Year: 1991
    ..PVEP has been reported to be abnormally prolonged in about 90 percent of patients with a clinical history of optic neuritis, despite a recovery of visual acuity and visual field in most patients...
  46. ONTT COOPERATING CLINIC
    Craig Smith; Fiscal Year: 1991
    This is an application to become one of the cooperating clinics in the Optic Neuritis Treatment Trial (ONTT)...
  47. Intrinsic Molecular Control of Axon Regeneration In RGCs
    Jeffrey Goldberg; Fiscal Year: 2007
    ..axon growth ability, and thereby to develop new treatments to promote RGC regeneration after injury in ocular diseases including glaucoma, retinal ischemia, optic neuritis and optic neuropathies. [unreadable] [unreadable] [unreadable]
  48. HIGH-PERFORMANCE COILS FOR MRI STUDIES OF THE EYE
    LINCOLN BOURNE; Fiscal Year: 1993
    ..Potential research and clinical applications include studies of cataractogenesis, diagnosis of intraocular and orbital tumors, and high resolution imaging of optic nerve damage in glaucoma and optic neuritis.
  49. Mechanisms and effects of phytoestrogen treatment in autoimmune optic neuritis
    MARTHA STOKELY; Fiscal Year: 2008
    ..applicant): Elevated endothelin-1 (ET-1) in the optic nerve may contribute to the pathogenesis of autoimmune optic neuritis, a common early manifestation of multiple sclerosis (MS) that can be modeled in rats with myelin ..
  50. Prevention of Neuronal Damage in Optic Neuritis
    KENNETH SHINDLER; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Optic neuritis is an inflammatory optic neuropathy that occurs in association with Multiple Sclerosis (MS) in about fifty percent of patients...
  51. Interferon Gamma Polymorphisms and Gender Bias in MS
    Brian Weinshenker; Fiscal Year: 2004
    ..If successful, this paradigm could be applied to a number of similar genetic association studies. ..
  52. Visual Dysfunction and Quality of Life in MS
    Laura Balcer; Fiscal Year: 2003
    ..This proposal will provide a crucial foundation for future studies of vision in MS that will involve longitudinal assessment. ..
  53. Novel Clinical and Ocular Imaging Outcomes with Long-Term Follow-Up in MS
    Laura Balcer; Fiscal Year: 2010
    ..that RNFL axonal loss over time is associated with worsening visual function, even in the absence of acute optic neuritis (ON)...
  54. Longitudinal Assessment of Visual Function in MS
    Laura Balcer; Fiscal Year: 2007
    ....
  55. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
    ..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..