disseminated intravascular coagulation

Summary

Summary: A disorder characterized by reduction in the elements involved in blood coagulation due to their utilization in widespread blood clotting within the vessels. The activation of the clotting mechanism may arise from any of a number of disorders. In the late stages, it is marked by profuse hemorrhaging. (Dorland, 27th ed)

Top Publications

  1. ncbi [Hypereosinophilic syndrome complicated by disseminated intravascular coagulation (DIC), deep venous thrombosis and pulmonary embolism]
    Junko Miyagi
    Division of Internal Medicine, Tokushima Red Cross Hospital, Tokushima
    Nihon Naika Gakkai Zasshi 93:364-6. 2004
  2. ncbi Sepsis and disseminated intravascular coagulation
    Marcel Levi
    Department of Internal Medicine Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Thrombolysis 16:43-7. 2003
  3. ncbi Infection and inflammation and the coagulation system
    Marcel Levi
    Department of Vascular Medicine and Internal Medicine F 4, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Cardiovasc Res 60:26-39. 2003
  4. ncbi Oxidative stress in septic shock and disseminated intravascular coagulation
    Daniela Salvemini
    MetaPhore Pharmaceuticals, St Louis, MO 63114, USA
    Free Radic Biol Med 33:1173-85. 2002
  5. ncbi A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Crit Care Med 34:625-31. 2006
  6. ncbi Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology
    M Levi
    Department of Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 145:24-33. 2009
  7. pmc Evidence of disseminated intravascular coagulation in a hemorrhagic fever with renal syndrome-scoring models and severe illness
    Erik Sundberg
    Department of Clinical Microbiology Infectious Diseases, Umea University, Umea, Sweden
    PLoS ONE 6:e21134. 2011
  8. ncbi Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial
    H Saito
    JR Tokai General Hospital, Nagoya, Japan
    J Thromb Haemost 5:31-41. 2007
  9. ncbi Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation
    J F Dhainaut
    Service de Reanimation Medicale, Center Hospitalo Universitaire Cochin Port Royal, AP HP, Paris V University, Paris, France
    J Thromb Haemost 2:1924-33. 2004
  10. pmc Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation
    Renee R Hukkanen
    University of Washington, Department of Comparative Medicine, Seattle, Washington 98195 7190, USA
    Toxicol Pathol 37:799-804. 2009

Research Grants

  1. MOLECULAR MECHANISMS OF SEPTIC SHOCK
    JACK HAWIGER; Fiscal Year: 2003
  2. Superantigen-Induced Vascular Injury and DIC
    JACK J HAWIGER; Fiscal Year: 2011
  3. Factor XI in Thrombosis
    David Gailani; Fiscal Year: 2013
  4. Rapid Label-Free Detection of Acute Promyelocytic Leukemia
    Lydia L Sohn; Fiscal Year: 2012
  5. Therapeutic factor XI blockade for sepsis
    ERIK IAN contact TUCKER; Fiscal Year: 2010
  6. Therapeutic factor XI blockade for sepsis
    ERIK IAN TUCKER; Fiscal Year: 2013
  7. The Thrombin-Thrombomodulin Interaction
    Elizabeth A Komives; Fiscal Year: 2012
  8. Tissue Factor Antagonists for ALI/ARDS
    Hing C Wong; Fiscal Year: 2013
  9. Circulating Tissue Factor: Characterization and Interactions with Factor IX
    LISA DIANE WILSBACHER; Fiscal Year: 2010
  10. Association of tissue factor pathway inhibitor with endothelium
    Alan E Mast; Fiscal Year: 2012

Detail Information

Publications317 found, 100 shown here

  1. ncbi [Hypereosinophilic syndrome complicated by disseminated intravascular coagulation (DIC), deep venous thrombosis and pulmonary embolism]
    Junko Miyagi
    Division of Internal Medicine, Tokushima Red Cross Hospital, Tokushima
    Nihon Naika Gakkai Zasshi 93:364-6. 2004
  2. ncbi Sepsis and disseminated intravascular coagulation
    Marcel Levi
    Department of Internal Medicine Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Thrombolysis 16:43-7. 2003
    ..leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation (DIC)...
  3. ncbi Infection and inflammation and the coagulation system
    Marcel Levi
    Department of Vascular Medicine and Internal Medicine F 4, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Cardiovasc Res 60:26-39. 2003
    ..lead to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation (DIC)...
  4. ncbi Oxidative stress in septic shock and disseminated intravascular coagulation
    Daniela Salvemini
    MetaPhore Pharmaceuticals, St Louis, MO 63114, USA
    Free Radic Biol Med 33:1173-85. 2002
    ..evidence suggests that oxidant stress plays a major role in several aspects of septic shock and disseminated intravascular coagulation (DIC), and it is the subject of this review...
  5. ncbi A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Crit Care Med 34:625-31. 2006
    ..scoring algorithm criteria established by the Japanese Association for Acute Medicine (JAAM) for disseminated intravascular coagulation (DIC) and to evaluate its diagnostic property by comparing the two leading scoring systems for DIC,..
  6. ncbi Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology
    M Levi
    Department of Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 145:24-33. 2009
    The diagnosis of disseminated intravascular coagulation (DIC) should encompass both clinical and laboratory information...
  7. pmc Evidence of disseminated intravascular coagulation in a hemorrhagic fever with renal syndrome-scoring models and severe illness
    Erik Sundberg
    Department of Clinical Microbiology Infectious Diseases, Umea University, Umea, Sweden
    PLoS ONE 6:e21134. 2011
    ..The general hypothesis is that disseminated intravascular coagulation (DIC) is an important part of the pathogenesis...
  8. ncbi Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial
    H Saito
    JR Tokai General Hospital, Nagoya, Japan
    J Thromb Haemost 5:31-41. 2007
    ..Soluble thrombomodulin is a promising therapeutic natural anticoagulant that is comparable to antithrombin, tissue factor pathway inhibitor and activated protein C...
  9. ncbi Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation
    J F Dhainaut
    Service de Reanimation Medicale, Center Hospitalo Universitaire Cochin Port Royal, AP HP, Paris V University, Paris, France
    J Thromb Haemost 2:1924-33. 2004
    b>Disseminated intravascular coagulation (DIC) is a serious condition associated with sepsis. Clinical management of DIC is hampered by lack of clear diagnostic criteria...
  10. pmc Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation
    Renee R Hukkanen
    University of Washington, Department of Comparative Medicine, Seattle, Washington 98195 7190, USA
    Toxicol Pathol 37:799-804. 2009
    ..mediators induces endothelial damage and microvascular thrombosis, potentially culminating in disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and multiple organ dysfunction (MOD) or failure ..
  11. ncbi Expert consensus for the treatment of disseminated intravascular coagulation in Japan
    Hideo Wada
    Department of Molecular and Laboratory Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie ken 514 8507, Japan
    Thromb Res 125:6-11. 2010
    ..Japanese Society of Thrombosis and Hemostasis provides an expert consensus for the treatment of disseminated intravascular coagulation (DIC) in Japan...
  12. ncbi Recombinant human soluble thrombomodulin improves mortality and respiratory dysfunction in patients with severe sepsis
    Yoshihito Ogawa
    Department of Emergency and Critical Care, Osaka General Medical Center, Osaka, Japan
    J Trauma Acute Care Surg 72:1150-7. 2012
    ..the efficacy of recombinant human soluble thrombomodulin (rhTM), a novel anticoagulant agent, for treating patients with sepsis-induced disseminated intravascular coagulation (DIC) in terms of mortality and respiratory dysfunction.
  13. pmc Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study
    Kazuma Yamakawa
    Department of Emergency and Critical Care, Osaka General Medical Center, 3 1 56 Bandai Higashi, Sumiyoshi ku, Osaka, Japan
    Crit Care 15:R123. 2011
    ..The purpose of this study was to examine the efficacy of rhTM for treating patients with sepsis-induced disseminated intravascular coagulation (DIC).
  14. ncbi Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
    Shock 33:14-8. 2010
    ..plays an important role in the development of acute respiratory distress syndrome (ARDS) and disseminated intravascular coagulation (DIC) in sepsis. Sivelestat is a selective neutrophil elastase inhibitor...
  15. ncbi The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients
    Karen M Hook
    Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 5:85-92. 2012
    b>Disseminated intravascular coagulation (DIC) profoundly increases the morbidity and mortality of patients who have sepsis. Both laboratory and clinical research advanced the understanding of the biology and pathophysiology of DIC...
  16. ncbi Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults
    Yara A Park
    Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA
    Am J Clin Pathol 133:460-5. 2010
    Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) and disseminated intravascular coagulation (DIC) may have identical manifestations in adults...
  17. ncbi The dynamics of angiogenic factors and their soluble receptors in relation to organ dysfunction in disseminated intravascular coagulation associated with sepsis
    Subrina Jesmin
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15W7, Kita ku, Sapporo, 060 8638, Japan
    Inflammation 36:186-96. 2013
    ..between angiogenic factors, their soluble receptors and organ dysfunction and (2) the effects of disseminated intravascular coagulation (DIC)-induced platelet consumption, thrombin generation, and tissue hypoxia on the expression of ..
  18. ncbi Disseminated intravascular coagulation in acute leukemia
    T Barbui
    Hematology Department, Ospedali Riuniti, Bergamo, Italy
    Semin Thromb Hemost 27:593-604. 2001
    ..may range from localized thrombosis to bleeding of varying degrees of severity because of disseminated intravascular coagulation (DIC)...
  19. ncbi Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Haemost 91:812-8. 2004
    ..The present data on the distribution of values may provide a basis for the selection of appropriate cutoff points for assigning 2, and 3 points in the score...
  20. ncbi Snakebite doesn't cause disseminated intravascular coagulation: coagulopathy and thrombotic microangiopathy in snake envenoming
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, and Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah NSW, Australia
    Semin Thromb Hemost 36:444-51. 2010
    ..VICC has often been likened to disseminated intravascular coagulation (DIC) because of the elevated D-dimer, prolonged prothrombin time, and low fibrinogen...
  21. ncbi Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, College of Sciences, George Mason University, 10900 University Boulevard, Manassas, VA 20110, USA
    J Biol Chem 283:9531-42. 2008
    ..with hemostatic imbalances manifested by thrombocytopenia, transient leucopenia, and aggressive disseminated intravascular coagulation. In this study we hypothesized that anthrax infection modulates the activity of von Willebrand ..
  22. ncbi Enhanced thrombin formation and fibrinolysis during acute Puumala hantavirus infection
    Outi Laine
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Thromb Res 126:154-8. 2010
    ..Nephropathia epidemica (NE) is a viral hemorrhagic fever with renal syndrome associated with thrombocytopenia and mild bleeding. We assessed activation of coagulation and fibrinolysis during the acute phase of NE...
  23. ncbi Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis
    Karim Brohi
    Department of Surgery, The Royal London Hospital, London, United Kingdom
    J Trauma 64:1211-7; discussion 1217. 2008
    ..The coagulopathy has recently been associated with systemic activation of the protein C pathway. This study was designed to characterize the thrombotic, coagulant and fibrinolytic derangements of trauma-induced shock...
  24. ncbi Fatal inhalational anthrax with unknown source of exposure in a 61-year-old woman in New York City
    Bushra Mina
    Section of Critical Care Medicine, Department of Medicine, Lenox Hill Hospital, 100 E 77th St, New York, NY 10021, USA
    JAMA 287:858-62. 2002
    ..The cause of death was inhalational anthrax. Despite epidemiologic investigation, including environmental samples from the patient's residence and workplace, no mechanism for anthrax exposure has been identified...
  25. ncbi Exogenous normal lymph alleviating kidney injury by improving coagulation function in disseminated intravascular coagulation rats
    Zi gang Zhao
    Institute of Microcirculation, Hebei North University, Hebei Zhangjiakou, PR China
    Ren Fail 34:221-6. 2012
    To investigate the effect of exogenous normal lymph on kidney injury in disseminated intravascular coagulation (DIC) rats and to probe its mechanism.
  26. ncbi Pathogenesis and treatment of disseminated intravascular coagulation in the septic patient
    M Levi
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Crit Care 16:167-77. 2001
    ..b>Disseminated intravascular coagulation (DIC), a syndrome that occurs frequently in septic patients, is associated with increased ..
  27. ncbi Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coagulation: subanalysis from the phase 3 trial
    Naoki Aikawa
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan
    Shock 35:349-54. 2011
    To investigate treatment effects of thrombomodulin alfa (TM-α) in patients with disseminated intravascular coagulation (DIC) having infection as the underlying disease, retrospective subanalysis of a double-blind, randomized controlled ..
  28. ncbi Disseminated intravascular coagulation: a review for the internist
    Marcel Levi
    Department of Medicine, University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Intern Emerg Med 8:23-32. 2013
    b>Disseminated intravascular coagulation (DIC) is a syndrome characterized by systemic intravascular activation of coagulation, leading to widespread deposition of fibrin in the circulation...
  29. pmc Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC)
    Liang Cai Wu
    Department of Dermatology, Huangpu Hospital of the First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Acta Pharmacol Sin 33:1254-9. 2012
    To evaluate the effects of tanshinone IIA (Tan IIA), a lipophilic diterpene from the Chinese herb Salvia miltiorrhiza, on lipopolysaccharide (LPS)-induced disseminated intravascular coagulation (DIC) in rabbits.
  30. ncbi Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange
    Timothy B Niewold
    Department of Rheumatology, Hospital for Special Surgery, New York, New York 10021, USA
    Am J Hematol 81:454-7. 2006
    We report the case of an immunocompetent woman who developed disseminated intravascular coagulation (DIC) due to acute cytomegalovirus (CMV) infection and was successfully treated with plasma exchange...
  31. ncbi Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation
    Sjoukje H Slofstra
    Center for Experimental and Molecular Medicine, G2 132, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Am J Respir Crit Care Med 176:602-9. 2007
    ..inflammatory response to systemic infection or severe trauma is characterized by the activation of a diversity of pathways, ultimately resulting in the development of disseminated intravascular coagulation (DIC) and multiorgan failure.
  32. ncbi Clinical course and outcome of disseminated intravascular coagulation diagnosed by Japanese Association for Acute Medicine criteria. Comparison between sepsis and trauma
    Shigeki Kushimoto
    Department of Emergency and Critical Care Medicine, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8603, Japan
    Thromb Haemost 100:1099-105. 2008
    The Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) study group recently announced new diagnostic criteria for DIC...
  33. ncbi Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury
    Oliver Grottke
    Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany
    Blood 118:1943-51. 2011
    ..Thromboembolism was found in all animals treated with 50 IU/kg PCC; 44% also showed signs of disseminated intravascular coagulation. Liver injury was similar in all animals...
  34. ncbi Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation
    Jungwon Hyun
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Thromb Res 124:75-9. 2009
    In disseminated intravascular coagulation (DIC), widespread activation of intravascular coagulation accompanied with florid endothelial activation results in release of unusually large von Willebrand factor (ULvWF) from endothelium...
  35. ncbi Trauma, shock, and disseminated intravascular coagulation: lessons from the classical literature
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Ann Surg 254:10-9. 2011
    ..Traumatic coagulopathy is multifactorial but disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype is the predominant and initiative pathogenesis of ..
  36. ncbi Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: results of a multicenter, prospective survey
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17 W5, Kita ku, Sapporo 060 8638 Japan
    Crit Care Med 36:145-50. 2008
    To survey the natural history of disseminated intravascular coagulation (DIC) in patients diagnosed according to the Japanese Association for Acute Medicine (JAAM) DIC scoring system in a critical care setting.
  37. ncbi Safety profile of recombinant factor VIIa
    Harold R Roberts
    Division of Hematology, Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, USA
    Semin Hematol 41:101-8. 2004
    ..Finally, those situations in which rFVIIa therapy may not be safe, such as disseminated intravascular coagulation (DIC) and sepsis, will also be discussed.
  38. ncbi The tissue factor pathway in disseminated intravascular coagulation
    B Østerud
    Department of Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Semin Thromb Hemost 27:605-17. 2001
    ..tissue factor (TF) exposed to the circulation is the sole culprit underlying the initiation of disseminated intravascular coagulation (DIC), although notable exceptions because of a more direct activation of the coagulation system, ..
  39. pmc Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 15:R272. 2011
    It is debated whether early trauma-induced coagulopathy (TIC) in severely injured patients reflects disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype, acute coagulopathy of trauma shock (ACoTS) or yet other ..
  40. ncbi Challenging problems in advanced malignancy: Case 2. Disseminated intravascular coagulation in metastatic hormone-refractory prostate cancer
    Lewis J Kampel
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 21:3170-1. 2003
  41. ncbi Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation
    M Levi
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 29:S90-4. 2001
    OBJECTIVE: In the pathogenesis of disseminated intravascular coagulation, dysfunctional natural anticoagulant pathways appear to play a pivotal role...
  42. ncbi Diagnosis and prognosis of overt disseminated intravascular coagulation in a general hospital -- meaning of the ISTH score system, fibrin monomers, and lipoprotein-C-reactive protein complex formation
    Ph Cauchie
    Clinical Laboratory, CHU Charleroi, A Vésale Hospital, Universite Libre de Bruxelles, Belgium
    Am J Hematol 81:414-9. 2006
    ..and the prognostic significance of the International Society of Thrombosis and Hemostasis overt disseminated intravascular coagulation (DIC) score and other parameters of coagulation activation including soluble fibrin monomer ..
  43. ncbi The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview
    C H Toh
    The Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Liverpool, UK
    J Thromb Haemost 5:604-6. 2007
  44. pmc Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin
    Leah N Cueni
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Blood 116:4376-84. 2010
    ..podoplanin-Fc-although produced specifically in the skin-entered the blood circulation and induced disseminated intravascular coagulation, characterized by microthrombi in most organs and by thrombocytopenia, occasionally leading to ..
  45. ncbi Evaluation of modified non-overt DIC criteria on the prediction of poor outcome in patients with sepsis
    D Oh
    Department of Internal Medicine, College of Medicine, Pochon CHA University, Sungnam, Korea
    Thromb Res 126:18-23. 2010
    The diagnostic performance of modified criteria for non-overt disseminated intravascular coagulation (DIC) with the addition of antithrombin (AT) levels, protein C (PC) levels, and organ system failure scoring (OSF) to the International ..
  46. ncbi Disseminated intravascular coagulation
    Marcel Levi
    Department of Vascular Medicine and Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care Med 35:2191-5. 2007
    To review the current knowledge on the clinical manifestation, pathogenesis, diagnosis, and management of disseminated intravascular coagulation (DIC).
  47. ncbi DIC: which laboratory tests are most useful
    Marcel Levi
    Department of Vascular Medicine and Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood Rev 25:33-7. 2011
    In patients with disseminated intravascular coagulation (DIC) a variety of altered coagulation parameters may be detectable, such as thrombocytopenia, prolonged global coagulation times, reduced levels of coagulation inhibitors, or high ..
  48. ncbi Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure
    Tomoko Ono
    Research Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical School, 3311 1 Yakushiji, Tochigi Ken 329 0498, Japan
    Blood 107:528-34. 2006
    ..In addition to TTP, ADAMTS13 levels were severely decreased in patients with sepsis-induced disseminated intravascular coagulation (DIC)...
  49. pmc Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation
    Kazue Takahashi
    Developmental Immunology Program, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunobiology 216:96-102. 2011
    ..Staphylococcus aureus infected MBL null mice developed disseminated intravascular coagulation (DIC), which was associated with elevated blood IL-6 levels (but not TNF-α and multi-organ ..
  50. ncbi Disseminated intravascular coagulation in infectious disease
    Marcel Levi
    Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Thromb Hemost 36:367-77. 2010
    ..lead to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. Systemic inflammation as a result of severe infection leads to activation of coagulation, due to ..
  51. ncbi Does disseminated intravascular coagulation lead to multiple organ failure?
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, Brussels 1070, Belgium
    Crit Care Clin 21:469-77. 2005
    ..This article discusses the evidence for and against a key role for disseminated intravascular coagulation in the pathogenesis of multiple organ failure.
  52. ncbi Increased soluble fibrin in plasma of patients with disseminated intravascular coagulation
    Hideo Wada
    Department of Laboratory Medicine, Mie University School of Medicine, Tsu City, Mie Ken, Japan
    Clin Appl Thromb Hemost 9:233-40. 2003
    Plasma levels of soluble fibrin (SF) were measured in 1184 patients with disseminated intravascular coagulation (DIC) according to Japanese Ministry of Health and Welfare (JMHW) criteria...
  53. ncbi International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients
    Claudia Voves
    Divison of Hematology and Central Hematology Laboratory, Kantonsspital Lucerne, Switzerland
    Blood Coagul Fibrinolysis 17:445-51. 2006
    We evaluated the score for disseminated intravascular coagulation (DIC) recently published by the International Society for Thrombosis and Haemostasis (ISTH) in a well-defined series of sepsis patients...
  54. pmc Disseminated intravascular coagulation as the presenting sign of metastatic prostate cancer
    Ignacio Duran
    Department of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada
    J Gen Intern Med 21:C6-8. 2006
    b>Disseminated intravascular coagulation (DIC) is an acquired coagulation disorder that may occur in a wide variety of clinical conditions...
  55. ncbi Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulation
    B Wiinberg
    Department of Small Animal Clinical Sciences, Faculty of Life Sciences, Small Animal Hospital, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 22:357-65. 2008
    There is considerable variation in the coagulation profile of dogs with disseminated intravascular coagulation (DIC), making it difficult to assess overall hemostatic function.
  56. ncbi Patient with disseminated intravascular coagulation as the first manifestation of adenocarcinoma of the prostate. Risks of prostatic biopsy
    M Navarro
    Oncology Department, Clinico Hospital, Salamanca, Spain
    Prostate Cancer Prostatic Dis 9:190-1. 2006
    b>Disseminated intravascular coagulation (DIC) can be a rare initial manifestation of adenocarcinoma of the prostate. We present a case in which DIC was the symptom leading to the suspicion of a prostatic tumour...
  57. ncbi Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality
    Atsushi Sawamura
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Japan
    Thromb Res 124:608-13. 2009
    b>Disseminated intravascular coagulation (DIC) with an antifibrinolytic phenotype is characterized by microvascular thrombosis leading to poor outcome at the late-stage of trauma...
  58. ncbi The coagulopathy of trauma versus disseminated intravascular coagulation
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, 21201, USA
    J Trauma 60:S12-9. 2006
    ..associated with serious injury, hypothermia, acidosis, hemodilution, and occasionally with classic disseminated intravascular coagulation (DIC)...
  59. ncbi Disseminated intravascular coagulation complicated by peripheral gangrene in a rhesus macaque (Macaca mulatta) experimentally infected with Plasmodium coatneyi
    Alberto Moreno
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 76:648-54. 2007
    We report the first case of disseminated intravascular coagulation (DIC) complicated by peripheral gangrene induced by Plasmodium coatneyi in rhesus monkeys...
  60. ncbi Diagnostic criteria and laboratory tests for disseminated intravascular coagulation
    Toshihiro Kaneko
    Department of Patient Safety and Infectinon Control, Mie University Graduate School of Medicine, Tsu, Japan
    J Clin Exp Hematop 51:67-76. 2011
    b>Disseminated intravascular coagulation (DIC) is associated with organ failure and it is often fatal condition. The main underlying diseases are infection, hematological malignancy and solid cancer...
  61. ncbi Higher prognostic value of soluble fibrin complexes than D-dimer and fibrin degradation product for disseminated intravascular coagulation in patients with liver cirrhosis
    Seon Young Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 24:150-6. 2013
    Fibrin-related markers may help differentiate disseminated intravascular coagulation (DIC) from liver cirrhosis-associated dysfunctional coagulation...
  62. ncbi Clinical use of D-dimer measurement for the diagnosis of disseminated intravascular coagulation in dogs
    Tatsuhiko Machida
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    J Vet Med Sci 72:1301-6. 2010
    ..results, we were able to divide the animals into four groups: control (healthy dogs, n=18), pre-disseminated intravascular coagulation (preDIC) (n=20), disseminated intravascular coagulation (DIC) (n=21), and other (n=146)...
  63. ncbi [Disseminated intravascular coagulation, perimyocarditis and bilateral pleural empyema in adult Still's disease]
    S Krzossok
    V Medizinische Klinik Nephrologie Endokrinologie Rheumatologie, Universitatsklinikum Mannheim, Germany
    Dtsch Med Wochenschr 129:2535-7. 2004
    ..A 21-year-old man was admitted to the hospital because of high fever, arthralgias and myalgias. One week before he was treated with penicillin G orally because of cough and sore throat...
  64. ncbi [Protein C deficiency in patient with sepsis-associated disseminated intravascular coagulation and deep vein thrombosis]
    Mauro Tassin
    Terapia Intensiva Pediatrica, Hospital Provincial de Neuquén Dr Eduardo Castro Rendón
    Arch Argent Pediatr 111:e28-30. 2013
    ..We report a patient with sepsis associated-DIC and concurrent deep venous thrombosis. The diagnostic evaluation allowed to discover inherited thrombophilia associated to protein C deficiency...
  65. pmc Bacillus anthracis cell wall peptidoglycan but not lethal or edema toxins produces changes consistent with disseminated intravascular coagulation in a rat model
    Ping Qiu
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 208:978-89. 2013
    b>Disseminated intravascular coagulation (DIC) appears to be important in the pathogenesis of Bacillus anthracis infection, but its causes are unclear. Although lethal toxin (LT) and edema toxin (ET) could contribute, B...
  66. ncbi Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS)
    S Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Thromb Haemost 11:826-35. 2013
    Two concepts have been proposed for the hemostatic changes occurring early after trauma. Disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype is characterized by activation of the coagulation pathways, insufficient ..
  67. ncbi Elevated levels of free tissue factor pathway inhibitor antigen in cases of disseminated intravascular coagulation caused by various underlying diseases
    H Asakura
    Department of Internal Medicine III, Kanazawa University School of Medicine, Japan
    Blood Coagul Fibrinolysis 12:1-8. 2001
    ..the concentration of free form TFPI was measured in the plasma of 114 patients suffering from disseminated intravascular coagulation (DIC), as the result of several underlying diseases...
  68. ncbi A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 41:2069-79. 2013
    To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation.
  69. ncbi Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation
    Soie Chung
    Department of Laboratory Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 125:e285-93. 2010
    ..We hypothesized that a hypercoagulable condition, such as disseminated intravascular coagulation (DIC), may increase circulating HGF through active cleavage by coagulation serine proteases.
  70. ncbi The diagnosis of disseminated intravascular coagulation
    Marcel Levi
    Department of Vascular Medicine and Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood Rev 16:217-23. 2002
    b>Disseminated intravascular coagulation (DIC) is a syndrome characterized by systemic intravascular activation of coagulation, leading to widespread deposition of fibrin in the circulation...
  71. ncbi Disseminated intravascular coagulation following transrectal ultrasound guided prostate biopsy
    M F Al-Otaibi
    Department of Urology, McGill University Health Centre, Montreal, Quebec, Canada
    J Urol 171:346. 2004
  72. ncbi Disseminated intravascular coagulation: What's new?
    Marcel Levi
    Department of Vascular and Internal Medicine F 4, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care Clin 21:449-67. 2005
    b>Disseminated intravascular coagulation (DIC) is a syndrome characterized by a systemic activation of coagulation leading to the intravascular deposition of fibrin in the (micro) vasculature and the simultaneous consumption of coagulation ..
  73. ncbi Sepsis-induced disseminated intravascular coagulation with features of thrombotic thrombocytopenic purpura: a fatal fulminant syndrome
    Zhaoyue Wang
    Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China
    Clin Appl Thromb Hemost 17:251-3. 2011
    b>Disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura (TTP) are different disease states, while ADAMTS13 deficiency could occur in sepsis-induced DIC...
  74. ncbi HIV infection presenting as severe autoimmune hemolytic anemia with disseminated intravascular coagulation in an infant
    Susan R Rheingold
    Divisions of Oncology, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Pediatr Hematol Oncol 26:9-12. 2004
    ..The authors describe a 5-month-old infant who presented with severe autoimmune hemolytic anemia and disseminated intravascular coagulation as his initial manifestation of HIV infection.
  75. pmc Thromboelastometry (TEM) findings in disseminated intravascular coagulation in a pig model of endotoxinemia
    Herbert Schöchl
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Mol Med 17:266-72. 2011
    Standard coagulation tests have a low specificity and sensitivity for diagnosing disseminated intravascular coagulation. The aim of this study was to determine whether whole blood thromboelastometry (TEM) detects lipopolysaccharide (LPS)-..
  76. ncbi Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation
    Seiji Madoiwa
    Research Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
    Thromb Res 127:349-55. 2011
    ..product by leukocyte elastase (e-XDP) were significantly increased in patients with sepsis induced disseminated intravascular coagulation (DIC) compared with healthy subjects (18.6±19.9 vs 0.58±0.47U/mL, p<0.001)...
  77. ncbi Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation
    Jeffrey G Gaca
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 73:1717-23. 2002
    Profound coagulopathy has been proposed as a barrier to xenotransplantation. Disseminated intravascular coagulation (DIC) has been observed with the rejection of renal and bone marrow xenografts but has not yet been described in pulmonary ..
  78. ncbi Early prediction of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6, and RANTES in preterm infants
    Pak C Ng
    Department of Pediatrics, Center of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
    Clin Chem 52:1181-9. 2006
    The progression to disseminated intravascular coagulation (DIC) in infected very low birth weight (VLBW; <1500 g) infants is difficult to predict with precision at the onset of sepsis...
  79. ncbi Thromboelastometry in patients with severe sepsis and disseminated intravascular coagulation
    Mirka Sivula
    Intensive Care Units, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Blood Coagul Fibrinolysis 20:419-26. 2009
    Severe sepsis induces coagulopathy, which may lead to disseminated intravascular coagulation (DIC). Thromboelastometry is a point-of-care whole blood coagulation monitor, which has been validated in human endotoxemia model...
  80. ncbi Disseminated intravascular coagulation in cancer patients
    Marcel Levi
    Department of Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Best Pract Res Clin Haematol 22:129-36. 2009
    b>Disseminated intravascular coagulation (DIC) is a syndrome that may complicate a variety of diseases, including malignant disease...
  81. ncbi Disseminated intravascular coagulation as an unusual presentation of Kala-azar: report of two cases
    Pravas Mishra
    Department of Haematology, All India Institute of Medical Sciences, New Delhi, India
    Scand J Infect Dis 36:519-21. 2004
    ..Bleeding is an uncommon manifestation of kala-azar. We report 2 cases, in which disseminated intravascular coagulation was an unusual complication.
  82. ncbi Encephalopathy, disseminated intravascular coagulation, and hemolytic-uremic syndrome after infection with enterohemorrhagic Escherichia coli O111
    Sadaya Matano
    Infection Control Unit, Tonami General Hospital, Tonami, Toyama, 939 1395, Japan
    J Infect Chemother 18:558-64. 2012
    ..Some patients, including adults, showed complications such as encephalopathy, disseminated intravascular coagulation, and hemolytic-uremic syndrome, and the disease course was extremely aggressive...
  83. ncbi Application of the Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria for patients at an early phase of trauma
    Atsushi Sawamura
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17W5, Kita ku, Sapporo, 060 8638 Japan
    Thromb Res 124:706-10. 2009
    To validate the diagnostic criteria for disseminated intravascular coagulation (DIC) established by the Japanese Association for Acute Medicine (JAAM) at an early stage of trauma and to evaluate the hypothesis that the JAAM criteria can ..
  84. ncbi Disseminated intravascular coagulation in hematologic malignancies
    Massimo Franchini
    Department of Pathology and Laboratory Medicine, Immunohematology and Transfusion Center, University Hospital, Parma, Italy
    Semin Thromb Hemost 36:388-403. 2010
    b>Disseminated intravascular coagulation (DIC) significantly contributes to the bleeding and thrombotic complications in patients with hematologic malignancies...
  85. ncbi Gastric cancer presenting with acute disseminated intravascular coagulation
    Aparna A Deshpande
    Department of Surgery, Seth G S Medical College and K E M Hospital, Mumbai
    Indian J Gastroenterol 21:164-5. 2002
    Patients presenting with acute disseminated intravascular coagulation (DIC) as the first symptom of malignancy are rare. A 68-year-old man presented with DIC. On evaluation, he was found to have adenocarcinoma of the stomach...
  86. ncbi Evaluation of new Japanese diagnostic criteria for disseminated intravascular coagulation in critically ill patients
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University, Graduate School of Medicine, Sapporo City, Japan
    Clin Appl Thromb Hemost 11:71-6. 2005
    New Japanese diagnostic criteria were prepared for disseminated intravascular coagulation (DIC) in critically ill patients and their usefulness was compared with the criteria of the International Society of Thrombosis and Haemostasis (..
  87. ncbi Neutrophil and monocyte activation markers have prognostic impact in disseminated intravascular coagulation: in vitro effect of thrombin on monocyte CD163 shedding
    Soie Chung
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Thromb Res 127:450-6. 2011
    Monocyte and neutrophil activation occur during microvascular disturbance of disseminated intravascular coagulation (DIC)...
  88. ncbi Effect of posttraumatic donor's disseminated intravascular coagulation in intrathoracic organ donation and transplantation
    M Valdivia
    Department of Intensive Care, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Transplant Proc 39:2427-8. 2007
    Our aim was to evaluate the influence on yield and function of intrathoracic organs from donors after severe cranial trauma complicated by disseminated intravascular coagulation (DIC).
  89. ncbi The diagnosis and management of disseminated intravascular coagulation
    Fletcher B Taylor
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Curr Hematol Rep 1:34-40. 2002
    This review describes disseminated intravascular coagulation (DIC) as a syndrome in which hemostatic factors are activated...
  90. ncbi The activation of neutrophil elastase-mediated fibrinolysis is not sufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation associated with systemic inflammation
    Satoshi Gando
    Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N17 W5, Kita ku, Sapporo 060 Japan
    Thromb Res 121:67-73. 2007
    ..test the hypothesis that the activation of neutrophil elastase-mediated fibrinolysis is insufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation (DIC) in patients associated with systemic inflammation.
  91. ncbi [Acute intermediate-risk pulmonary embolism with right-sided free-floating intracardiac thrombus, systemic inflammatory reaction syndrome, multiple organ dysfunction syndrome, disseminated intravascular coagulation and acute ischaemia of a limb]
    Paweł Grzelakowski
    Klinika Kardiologii i Kardiochirurgii, 10 Wojskowy Szpital Kliniczny z Polikliniką, Bydgoszcz
    Kardiol Pol 68:1140-4. 2010
    ..heart thrombi, systemic inflammatory reaction syndrome, multiple organ dysfunction syndrome, disseminated intravascular coagulation and acute ischaemia of the right lower limb...
  92. ncbi Anti-heparin/PF4 complexes by ELISA in patients with disseminated intravascular coagulation
    Takefumi Matsuo
    Hyogo Prefectural Awaji Hospital, Sumoto, Japan
    Pathophysiol Haemost Thromb 36:305-10. 2007
    Heparin-induced thrombocytopenia (HIT) is known to complicate disseminated intravascular coagulation (DIC), but rarely to be complicated by DIC...
  93. ncbi [A case of septic shock and disseminated intravascular coagulation following transrectal prostatic biopsy]
    K Kato
    Department of Urology, Red Cross Nagoya First Hospital
    Nippon Hinyokika Gakkai Zasshi 92:706-9. 2001
    ..B immobilized fiber column (PMX), was useful to recover the patient from septic shock and disseminated intravascular coagulation. As the number of systematic prostatic biopsy is increasing rapidly in Japan, more attention must ..
  94. ncbi [Disseminated intravascular coagulation in eperythrozoonosis of swine]
    G Plank
    II Medizinischen Tierklinik der Universität München
    Berl Munch Tierarztl Wochenschr 103:13-8. 1990
    ..Anti-rickettsial therapy led to quick normalization of haemostasis. Various aspects of the cause and the consequences of the haemostatic defect are discussed with special regard to the underlying disease...
  95. ncbi Disseminated intravascular coagulation with excessive fibrinolysis in prostate cancer: a case series and review of the literature
    David M Hyman
    Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Oncology 81:119-25. 2011
    To describe the clinical characteristics, diagnostic features, prognosis, and outcome of patients with prostate cancer and disseminated intravascular coagulation with excessive fibrinolysis (DIC XFL).
  96. ncbi Trombocytopenia: one of the markers of disseminated intravascular coagulation
    Hugo ten Cate
    Department of Internal medicine and Laboratory for Clinical Thrombosis and Hemostasis, Academic Hospital Maastricht and Cardiovascular Research Institute Maastricht, The Netherlands
    Pathophysiol Haemost Thromb 33:413-6. 2003
    b>Disseminated intravascular coagulation (DIC) is a complication of a variety of severe underlying diseases and a contributing factor in multi-organ failure and death...
  97. ncbi A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis
    Christian J Wiedermann
    Division of Internal Medicine II, Department of Medicine, Central Hospital of Bolzano, Bolzano Bozen, Italy
    Blood Coagul Fibrinolysis 17:521-6. 2006
    The objective was to estimate the effect of antithrombin therapy on mortality in disseminated intravascular coagulation (DIC) of severe sepsis and septic shock...
  98. ncbi Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation
    Satoshi Gando
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita ku, Sapporo 060 Japan
    Thromb Res 116:91-100. 2005
    ..activation markers as well as to investigate the correlationship among the inflammation markers, disseminated intravascular coagulation (DIC), and multiple organ dysfunction syndrome (MODS) in patients with sepsis, we made this ..
  99. ncbi Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase
    Mineji Hayakawa
    Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Surgery 149:221-30. 2011
    The aims of the present study were to confirm the consumption coagulopathy of disseminated intravascular coagulation with the fibrinolytic phenotype at an early phase of trauma and to test the hypothesis that thrombin-activatable ..
  100. ncbi Current understanding of disseminated intravascular coagulation
    Marcel Levi
    Department of Vascular Medicine and Internal Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Haematol 124:567-76. 2004
  101. ncbi Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review
    Massimo Franchini
    Immunohematology and Transfusion Center, City Hospital of Verona, Italy
    Blood Coagul Fibrinolysis 18:589-93. 2007
    ..of this hemostatic agent in severe bleeding, unresponsive to standard treatment, associated with disseminated intravascular coagulation. A total of 99 disseminated intravascular coagulation-associated bleeding episodes treated with ..

Research Grants61

  1. MOLECULAR MECHANISMS OF SEPTIC SHOCK
    JACK HAWIGER; Fiscal Year: 2003
    The focus of this application is molecular mechanisms of septic shock with attendant Disseminated Intravascular Coagulation (DIC) affecting annually 400,000 hospitalized patients in the US...
  2. Superantigen-Induced Vascular Injury and DIC
    JACK J HAWIGER; Fiscal Year: 2011
    ..pneumonia often complicated by Acute Respiratory Distress Syndrome (ARDS), Toxic Shock, and Disseminated Intravascular Coagulation (DIC)...
  3. Factor XI in Thrombosis
    David Gailani; Fiscal Year: 2013
    ..In Aim 3 we will compare the effects of fXI deficiency on survival, disseminated intravascular coagulation, and inflammation to those of deficiencies of fXII, HK, and PK in a model of polymicrobial sepsis ..
  4. Rapid Label-Free Detection of Acute Promyelocytic Leukemia
    Lydia L Sohn; Fiscal Year: 2012
    ..7% of newly- diagnosed APL patients in the United States die within the first 48 hours, often of disseminated intravascular coagulation (DIC)...
  5. Therapeutic factor XI blockade for sepsis
    ERIK IAN contact TUCKER; Fiscal Year: 2010
    ..Ischemia contributes to the pathogenesis of sepsis-associated disseminated intravascular coagulation (DIC) and systemic inflammatory response syndrome (SIRS)...
  6. Therapeutic factor XI blockade for sepsis
    ERIK IAN TUCKER; Fiscal Year: 2013
    ..Sepsis-associated disseminated intravascular coagulation (DIC) contributes to organ perfusion deficits, ischemia, and a systemic inflammatory response ..
  7. The Thrombin-Thrombomodulin Interaction
    Elizabeth A Komives; Fiscal Year: 2012
    ..of better anticoagulants and for understanding the potential of TM fragments in the treatment of disseminated intravascular coagulation. To gain information on the dynamic allostery in the thrombin-TM interaction, we will obtain ..
  8. Tissue Factor Antagonists for ALI/ARDS
    Hing C Wong; Fiscal Year: 2013
    ..plasma TF levels correlated with increased mortality, fewer ventilator-free days, the presence of disseminated intravascular coagulation and the progression to sepsis in patients with ALI/ARDS, suggesting that systemic activation of ..
  9. Circulating Tissue Factor: Characterization and Interactions with Factor IX
    LISA DIANE WILSBACHER; Fiscal Year: 2010
    ..Data using such mice suggest that endothelial and hematopoietic Tf is necessary for disseminated intravascular coagulation in mouse models of endotoxemia...
  10. Association of tissue factor pathway inhibitor with endothelium
    Alan E Mast; Fiscal Year: 2012
    ..the Tissue Factor-factor VIIa (TF-fVIIa) catalytic complex preventing intravascular thrombosis, disseminated intravascular coagulation, tumor metastasis and other pathologies associated with production of TF within the vasculature...
  11. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    ..minimal localized proinflammatory cytokine expression), or its progression to septic shock with disseminated intravascular coagulation (DIG) and multiple organ failure (MOF)...
  12. PRIMATE MODEL AND PATHOGENESIS OF ANTHRAX SEPSIS
    Shinichiro Kurosawa; Fiscal Year: 2009
    ..anthrax developed a severe coagulopathy and experienced organ failure and other complications from disseminated intravascular coagulation. These responses are similar to the uncompensated inflammatory responses which contribute directly ..
  13. HEPARIN INDUCED THROMBOCYTOPENIA/THROMBOSIS
    GIAN VISENTIN; Fiscal Year: 2000
    ..basis for thrombocytopenia and the mechanism(s) responsible for the associated thrombosis and disseminated intravascular coagulation (DIC) are poorly understood...
  14. Novel Recombinant Anticoagulant Proteins
    TZE CHEIN WUN; Fiscal Year: 2005
    ..angina, acute myocardial infarction, ischemic stroke, deep vein thrombosis, pulmonary embolism, disseminated intravascular coagulation, and peripheral vascular disease...
  15. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2000
    ..toxic shock syndrome-like manifestations, adult respiratory distress syndrome, meningitis, and disseminated intravascular coagulation in immunocompetent patients, overwhelming opportunistic infection in immunocompromised patients, ..
  16. Mechanisms of MDMA-induced hyperthermia
    Edward Mills; Fiscal Year: 2009
    ..including skeletal muscle breakdown, cardiovascular collapse, multi-organ failure, and disseminated intravascular coagulation. In animals, hyperthermia also strongly potentiates long term neurotoxicity...
  17. INTERACTION OF LIPOPOLYSACCHARIDES WITH SERUM PROTEINS
    STANLEY VUKAJLOVICH; Fiscal Year: 1991
    ..released from the bacterium following serum bacteriolysis, which include shock, hypotension and disseminated intravascular coagulation. In spite of the numerous serum factors reported to detoxify the endotoxic activities of LPS both ..
  18. Extracorporeal Blood Purification For Sepsis Therapy
    Susan Szathmary; Fiscal Year: 2006
    ..benefit early in the development of the disease to decrease the inflammation, vascular damage and disseminated intravascular coagulation, as well as later where they experience immuno-paralysis due to an exhausted immune system...
  19. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2009
    ..and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated intravascular coagulation (DIG) and microvascular thrombosis...
  20. ANALYSIS OF FACTOR VIII COAGULANT ANTIGEN
    Mark Weinstein; Fiscal Year: 1990
    ..such as vWF disease and hemophilia A but in acquired disorders including renal dysfunction, disseminated intravascular coagulation, heart disease, and pregnancy...
  21. INHIBITORS OF THE EXTRINSIC BLOOD COAGULATION PATHWAY
    TERENCE BRUNCK; Fiscal Year: 1991
    b>Disseminated intravascular coagulation (DIC) is a disease process associated with septicemia cancer, and viremia that kills over 107,000 individuals each year in the U.S...
  22. PLATELET-ENDOTHELIAL DYSFUNCTION BY FIBRINOGEN PEPTIDE
    Charles Chen; Fiscal Year: 1992
    ..FDPs/fdps are generated in conditions such as disseminated intravascular coagulation (DIC) and during thrombolytic therapy...
  23. REGULATORY ROLES OF LACTOFERRIN IN HEMOSTASIS
    Haifeng Wu; Fiscal Year: 2003
    ..can contribute significantly to the development of prothrombotic sequelae as seen in the disseminated intravascular coagulation (DIC) associated with bacterial infections; and (iii) the structural determinant(s) of lactoferrin ..
  24. IMMUNOCHEMISTRY OF ENDOTOXIN UNRESPONSIVE C3H/HEJ MICE
    David Morrison; Fiscal Year: 1999
    Bacterial endotoxic lipopolysaccharides (LPS) can initiate fever, profound hypotension (shock), disseminated intravascular coagulation, multisystem organ failure and death...
  25. BIOCHEMICAL PARAMETERS OF LPS-INITIATED HOST RESPONSE
    David Morrison; Fiscal Year: 1990
    ..mediation systems will provide fundamental information on the contribution of these biologically active macromolecules to the hypotension and disseminated intravascular coagulation characteristic of patients with gram negative sepsis.
  26. Adenovirus vectors and complement system
    Andrea Amalfitano; Fiscal Year: 2007
    ..anaphylactoid reactions, ARDS (adult respiratory distress syndrome), hypotensive shock, DIC (disseminated intravascular coagulation), cytokine release and systemic inflammatory response syndromes...
  27. PROTEIN C STRUCTURE/FUNCTION & RISK OF THROMBOSIS
    JOSEPH MILETICH; Fiscal Year: 1993
    ..Protein C in inherited and acquired disorders that are characterized by venous thrombosis and/or disseminated intravascular coagulation. Protein C circulates in plasma as a distribution of different molecular species, all potentially ..
  28. MOLECULAR MECHANISMS FOR VASCULAR CELL DEACTIVATION
    Warren Johnson; Fiscal Year: 2000
    ..diseases of overt vascular cell activation accounting for a major proportion of acute and chronic illness of American including sepsis, ARDS, disseminated intravascular coagulation, atherosclerosis, autoimmune disease and HIV/AIDS.
  29. A CHEMICALLY SYNTHETIC ANTI-TOXIC VACCINE AGAINST MALARI
    Louis Schofield; Fiscal Year: 2002
    ..The toxin initiates a systemic inflammatory cascade involving cytokine excess, which may result in disseminated intravascular coagulation, hepatic dysfunction, acute renal failure, multi-organ inflammation, hypoglycemia, lactic acidosis ..
  30. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  31. Procoagulants in Aging CARDIA Participants
    David Green; Fiscal Year: 2009
    ....
  32. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..
  33. Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic Cells
    Kazue Takahashi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Gammacell-220 Excel Refurbished Research Irradiator
    David Walker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  35. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  36. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2004
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
  37. Pathophysiologies Involving Hemostasis-related Genes
    Francis Castellino; Fiscal Year: 2008
    ..is the definition of the in vivo roles of hemostasis-related genes in: the relationships between disseminated intravascular coagulation, systemic inflammation, and organ damage during the progression of sepsis (Project by Castellino); ..
  38. TB/HIV RISK REDUCTION WITH HOMELESS AND DRUG ADDICTED
    Adeline Nyamathi; Fiscal Year: 2002
    ....
  39. PAR SIGNALING AND PROTECTIVE PATHWAYS IN INFLAMMATION AND SEPSIS
    Wolfram Ruf; Fiscal Year: 2010
    ..3. ..
  40. Community-Based Approach to Designing an AIDS Program for HIV+ Mothers in India
    Adeline Nyamathi; Fiscal Year: 2008
    ..These findings will lead to future funding to actually develop and test a newly designed program. [unreadable] [unreadable] [unreadable]..
  41. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  42. CELL MEDIATED HEMOSTASIS
    Harold Roberts; Fiscal Year: 2004
    ....
  43. Oral Epithelial Cells: Innate Immune "Gatekeeper" of HIV
    MARK HERZBERG; Fiscal Year: 2006
    ..Innate immune factor-related genes may prove to be novel targets to prevent mucosal HIV. ..
  44. FUNCTIONAL ANALYSIS OF VASCULAR NTPDASES
    Simon Robson; Fiscal Year: 2007
    ..Information gleaned from these studies may direct new therapeutic strategies for inflammatory vascular disorders, including atherosclerotic cardiovascular disease. ..
  45. Purinergic Thromboregulation
    Simon C Robson; Fiscal Year: 2010
    ..d) Study thrombus formation in hyperlipidemic Cd39 mutant mice. This work will provide insights into the central thromboregulatory mechanisms impacting platelet activation and vascular injury in vivo. ..
  46. TARGETING SIGNALING OF THE TISSUE FACTOR PATHWAY
    Wolfram Ruf; Fiscal Year: 2007
    ..abstract_text> ..
  47. NUCLEOTIDE DONORS AFFECTING GLYCOSYLATION PATHWAYS
    Ajit Varki; Fiscal Year: 2003
    ....
  48. SELENOPROTEINS, NF-KB, AND HIV DISEASE IN IV DRUG USERS
    ETHAN TAYLOR; Fiscal Year: 2003
    ..The long- term goal is to establish a molecular basis for the use of Se supplements as a chemoprotectant in HIV+ drug users. ..
  49. S. sanguis Adhesion: Molecular Basis of Specificity
    MARK HERZBERG; Fiscal Year: 2009
    ..abstract_text> ..
  50. VASCULAR NTPDASES AND TRANSPLANTATION
    Simon Robson; Fiscal Year: 2004
    ..These experiments should delineate involvement of NTPDases and P2signaling in inflammation associated with arterial/venous injury and also culminating in allograft failure. ..
  51. EFFECTS OF TF/FVIIa INHIBITION IN CRP TRANSGENIC MICE
    Christopher Arnold; Fiscal Year: 2004
    ..Together, these models will help determine the in vivo anti-inflammatory and antithrombotic properties of BCX-3607, a potential agent for the treatment of acute coronary syndromes. ..
  52. Alcohol Use Reduction in Methadone Individuals with HCV
    Adeline Nyamathi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. Proteomic studies of pathogenic Leptospira
    Jarlath Nally; Fiscal Year: 2004
    ....
  54. VEE PATHOGENESIS AND VACCINE DEVELOPMENT
    Slobodan Paessler; Fiscal Year: 2007
    ..By dissecting the nonstructural proteins of VEEV from the structural proteins, the role of replieative machinery (nonstructural proteins) in the pathogenesis will be elucidated. ..
  55. INNATE INTRAEPITHELIAL DEFENSE AGAINST ORAL INFECTION
    MARK HERZBERG; Fiscal Year: 2006
    ..abstract_text> ..
  56. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  57. THE CELLULAR STRESS RESPONSE IN VIRAL ENCEPHALITIS
    Michael Oglesbee; Fiscal Year: 2008
    ..The experimental system uses measles virus, but the work has potential broad relevance to other viruses that infect brain. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Platelet Receptor Mediated Factor X Activation
    Peter Walsh; Fiscal Year: 2005
    ..We will determine the platelet agonists, receptors, signal transduction and effector mechanisms required for binding the components of the FX-activating complex. ..
  59. Quantitative multimodal analyses in pediatric epilepsy surgery
    Eishi Asano; Fiscal Year: 2008
    ..If funded, the applicant will achieve the necessary training in an excellent environment to develop into an independent investigator. [unreadable] [unreadable]..
  60. EARLY DETERMINATION OF STROKE SUBTYPE: CT ANGIOGRAPHY
    Scott Kasner; Fiscal Year: 2003
    ..This approach will, for the first time, formally evaluate CTA as a tool for early stroke diagnosis and selection of patients with specific stroke mechanisms for specific mechanism-directed stroke therapies. ..