experimental leukemia

Summary

Summary: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.

Top Publications

  1. pmc Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors
    W Chen
    Division of Oncology, Department of Medicine, University of Washington, Seattle 98195, USA
    J Virol 70:7773-82. 1996
  2. pmc Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia
    Pavinder Kaur
    Section of Molecular Carcinogenesis, Division of Hematology Oncology, Saban Research Institute, Childrens Hospital Los Angeles and the Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Cancer 6:67. 2007
  3. ncbi The roles of FLT3 in hematopoiesis and leukemia
    D Gary Gilliland
    Brigham and Women s Hospital, Howard Hughes Medical Institute, Boston, MA, USA
    Blood 100:1532-42. 2002
  4. pmc Generation of novel syncytium-inducing and host range variants of ecotropic moloney murine leukemia virus in Mus spicilegus
    Yong Tae Jung
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 77:5065-72. 2003
  5. pmc Infection of central nervous system cells by ecotropic murine leukemia virus in C58 and AKR mice and in in utero-infected CE/J mice predisposes mice to paralytic infection by lactate dehydrogenase-elevating virus
    G W Anderson
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455 0312
    J Virol 69:308-19. 1995
  6. pmc Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells
    M Iwashiro
    Institute for Immunology, Faculty of Medicine, Kyoto University, Japan
    J Virol 67:4533-42. 1993
  7. ncbi STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model
    Lei Gao
    Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Chin Med J (Engl) 119:911-8. 2006
  8. ncbi A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl
    S Mishra
    Division of Hematology Oncology, Section of Molecular Carcinogenesis, Childrens Hospital of Los Angeles Research Institute, Los Angeles, CA 90027, USA
    Leukemia 18:23-8. 2004
  9. ncbi A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus
    Polyxeni Gourzi
    Laboratory of Lymphocyte Biology, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Immunity 24:779-86. 2006
  10. pmc Major histocompatibility complex class II-regulated immunity to murine leukemia virus protects against early T- but not late B-cell lymphomas
    W L Vasmel
    Division of Immunology, The Netherlands Cancer Institute, Amsterdam
    J Virol 62:3156-66. 1988

Research Grants

  1. LIPOPHILIC PROBES FOR TUMOR CELL SURFACES
    Fritz Sieber; Fiscal Year: 1990
  2. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
  3. Selective in vivo Ablation of Leukemia Stem Cells
    Craig Jordan; Fiscal Year: 2009
  4. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2005
  5. Cellular and Molecular Studies of Leukemic Stem Cellss
    Craig Jordan; Fiscal Year: 2006
  6. Amnis ImageStream Flow Cytometer
    Craig Jordan; Fiscal Year: 2007
  7. Search for the Molecular Targets of Phenols
    CYNTHIA SELASSIE; Fiscal Year: 2006
  8. mTOR Signaling In Chronic Myelogenous Leukemia
    Hung Fan; Fiscal Year: 2009
  9. Screen for Mycobacterium Tuberculosis (RMI)
    E White; Fiscal Year: 2005
  10. ISOLATION OF THE NEUROBLASTOMA PREDISPOSITION GENE
    John Maris; Fiscal Year: 2006

Detail Information

Publications206 found, 100 shown here

  1. pmc Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors
    W Chen
    Division of Oncology, Department of Medicine, University of Washington, Seattle 98195, USA
    J Virol 70:7773-82. 1996
    ..Thus, the CTL epitope of FBL-3 is localized to the transmembrane anchor domain of the nonstructural Gag polyprotein and is shared by leukemia/lymphoma cell lines induced by Friend, Moloney, and Rauscher MuLV...
  2. pmc Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia
    Pavinder Kaur
    Section of Molecular Carcinogenesis, Division of Hematology Oncology, Saban Research Institute, Childrens Hospital Los Angeles and the Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Cancer 6:67. 2007
    ..Because Ph-positive acute lymphoblastic leukemia only responds transiently to imatinib therapy, we have used mouse models to test the efficacy of nilotinib against lymphoblastic leukemia caused by the P190 form of Bcr/Abl...
  3. ncbi The roles of FLT3 in hematopoiesis and leukemia
    D Gary Gilliland
    Brigham and Women s Hospital, Howard Hughes Medical Institute, Boston, MA, USA
    Blood 100:1532-42. 2002
    ..Taken together, these results suggest that FLT3 is an attractive therapeutic target for kinase inhibitors or other approaches for patients with mutations of this gene...
  4. pmc Generation of novel syncytium-inducing and host range variants of ecotropic moloney murine leukemia virus in Mus spicilegus
    Yong Tae Jung
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 77:5065-72. 2003
    ..dunni...
  5. pmc Infection of central nervous system cells by ecotropic murine leukemia virus in C58 and AKR mice and in in utero-infected CE/J mice predisposes mice to paralytic infection by lactate dehydrogenase-elevating virus
    G W Anderson
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455 0312
    J Virol 69:308-19. 1995
    ....
  6. pmc Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells
    M Iwashiro
    Institute for Immunology, Faculty of Medicine, Kyoto University, Japan
    J Virol 67:4533-42. 1993
    ..In addition, a possible third epitope was located in the N-terminal half of the gp70 sequence and differed from the first epitope in that it was not cross-reactive with the Moloney MuLV envelope protein...
  7. ncbi STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model
    Lei Gao
    Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Chin Med J (Engl) 119:911-8. 2006
    ..Since STI571 may reverse multidrug-resistance of K562/MDR cells in vitro, we studied the effect of STI571 on multidrug-resistant K562 cells in vivo...
  8. ncbi A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl
    S Mishra
    Division of Hematology Oncology, Section of Molecular Carcinogenesis, Childrens Hospital of Los Angeles Research Institute, Los Angeles, CA 90027, USA
    Leukemia 18:23-8. 2004
    ..We conclude that SCH66336, on its own, is remarkably effective in eradicating large numbers of lymphoblastic lymphoma cells and causing visible reduction in tumor size, with minimal toxicity...
  9. ncbi A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus
    Polyxeni Gourzi
    Laboratory of Lymphocyte Biology, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Immunity 24:779-86. 2006
    ..Hence, in addition to its known function in immunoglobulin diversification, AID is active in innate defense against a transforming retrovirus...
  10. pmc Major histocompatibility complex class II-regulated immunity to murine leukemia virus protects against early T- but not late B-cell lymphomas
    W L Vasmel
    Division of Immunology, The Netherlands Cancer Institute, Amsterdam
    J Virol 62:3156-66. 1988
    ..We conclude that the pleiotropic effects of MCF 1233 infection in H-2-congenic mice result from MHC class II I-A-determined T-cell response differences...
  11. pmc The effect of class II gene transfection on the tumourigenicity of the H-2K-negative mouse leukaemia cell line K36.16
    R F James
    Department of Surgery, Leicester University
    Immunology 72:213-8. 1991
    ..This suggests that the induction of class II antigen expression on tumour cells may provide an effective way of enhancing tumour-specific immune responses in vivo...
  12. pmc Low-frequency loss of heterozygosity in Moloney murine leukemia virus-induced tumors in BRAKF1/J mice
    J K Lander
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717, USA
    J Virol 71:3940-52. 1997
    ..These results suggested that tumor suppressor inactivation is generally infrequent in M-MuLV-induced tumors but that a subset of these tumors may have lost a tumor suppressor gene on chromosome 4...
  13. pmc LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor
    E Koustova
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases/NIH, Bethesda, Maryland 20892-0008, USA
    J Clin Invest 107:737-44. 2001
    ..These Ab's may alter neuronal signaling and contribute to the neurodegeneration observed in these mice, actions that may be curtailed by the use of AMPA-receptor antagonists...
  14. pmc Role of natural killer cells in resistance against friend retrovirus-induced leukemia
    N Iwanami
    Department of Immunology, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan
    J Virol 75:3152-63. 2001
    ....
  15. pmc Novel role of CD8(+) T cells and major histocompatibility complex class I genes in the generation of protective CD4(+) Th1 responses during retrovirus infection in mice
    Karin E Peterson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 76:7942-8. 2002
    ..The ability of MHC class I genes to facilitate CD4(+) Th1 development could also be considerable evolutionary advantage by allowing a wider variety of MHC genotypes to generate protective immune responses against intracellular pathogens...
  16. ncbi Role of lymphoid cells in age-related change of susceptibility to Friend leukemia virus-induced leukemia
    S Yamaguchi
    Department of Pathology and Immunology, Aging and Developmental Sciences, Faculty of Medicine, Tokyo Medical and Dental University, Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    Mech Ageing Dev 122:219-32. 2001
    ..Discussion was made on the possible implication of these findings on the role of T cells in age-related change of resistance to FLV-induced leukemogenesis...
  17. ncbi Decreased IL-2, IFN-gamma, and IL-10 production by aged mice during the acute phase of E55+ retrovirus infection
    Mohamed Elrefaei
    Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Virology 299:8-19. 2002
    ..i. in young, but primarily by CD8(+) T cells, in aged mice. Therefore, delayed virus clearance is associated with age-related decreases in type 1 and type 2 cytokines and a shift in the primary source of at least one cytokine...
  18. pmc Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus
    Shelly J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Virol 82:408-18. 2008
    ..Coinfection of mice with LDV and FV provides a well-defined, natural host model for such studies...
  19. ncbi Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic mice
    D Louz
    Institute of Hematology, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    Leukemia 14:1876-84. 2000
    ..Taken together, our results present the first evidence of Evi1 disturbing normal erythropoiesis in vivo and provides evidence for cooperative potential of Evi1 in tumor progression...
  20. ncbi F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4
    J Kone
    Department of Pathology, Yale University, New Haven, CT, USA
    Leukemia 16:1827-34. 2002
    ..Study of this locus may provide insight into genes involved in AML-associated 7q32 deletions in humans...
  21. pmc Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice
    H J Super
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 72:9400-3. 1998
    ..These studies revealed the first evidence for a functional T-cell response following FV infection in these low-recovery mice and showed that CD4(+) T-helper cells are required for the Rfv-3-controlled FV antibody response...
  22. pmc Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing
    Catherine Denicourt
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    J Virol 77:37-44. 2003
    ..1-kb transcript from the cyclin D2 gene that encodes a truncated cyclin D2 of 17 kDa. The expression of this 1.1-kb transcript is specific to tumors in which Gris1 is rearranged but is also detected at low levels in normal tissue...
  23. pmc Friend leukemia virus infection enhances DNA damage-induced apoptosis of hematopoietic cells, causing lethal anemia in C3H hosts
    Masanobu Kitagawa
    Department of Pathology and Immunology, Aging and Developmental Sciences, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Virol 76:7790-8. 2002
    ....
  24. ncbi Effects of chronic methamphetamine exposure on heart function in uninfected and retrovirus-infected mice
    Qianli Yu
    College of Public Health, School of Medicine, Health Promotion Science Division, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Life Sci 71:953-65. 2002
    ..These data suggest that MA induced myocardial cellular changes compensate for retrovirus induced DCM...
  25. ncbi Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10
    R Koller
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Virology 224:224-34. 1996
    ..It is anticipated that future experiments will determine whether Mml1 integration prevents down regulation of c-myb expression or activates another gene on chromosome 10...
  26. ncbi Operating under a Gag order: a block against incoming virus by the Fv1 gene
    S P Goff
    HHMI and Depts of Microbiology and Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 86:691-3. 1996
  27. ncbi Modulation of fas/fasL in a murine retroviral infection by AZT and methionine enkephalin
    R Bowden
    University of South Florida College of Medicine, Department of Medical Microbiology and Immunology, Tampa 33612, USA
    Adv Exp Med Biol 493:143-52. 2001
  28. pmc Analysis of the disease potential of a recombinant retrovirus containing Friend murine leukemia virus sequences and a unique long terminal repeat from feline leukemia virus
    Kazuo Nishigaki
    Basic Research Laboratory, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    J Virol 76:1527-32. 2002
    ....
  29. ncbi Positional cloning of the mouse retrovirus restriction gene Fv1
    S Best
    Division of Virology, National Institute for Medical Research, London, UK
    Nature 382:826-9. 1996
    ....
  30. ncbi Anti-inflammatory effects of theophylline: modulation of immune functions during murine leukemia virus infection
    B Liang
    College of Public Health and School of Medicine, University of Arizona, Tucson 85724, USA
    Immunopharmacol Immunotoxicol 23:307-19. 2001
    ..These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment...
  31. ncbi A gene therapy model for retrovirus-induced disease with a viral env gene: expression-dependent resistance in immunosuppressed hosts
    M Kitagawa
    Department of Pathology and Immunology, Aging and Developmental Sciences, Tokyo Medical and Dental University, Graduate School, Japan
    Leukemia 15:1779-84. 2001
    ..These chimeras also resisted FLV-induced leukemogenesis, indicating that receptor interference-based gene therapy could become a therapeutic basis for immunodeficiency virus-induced diseases in vivo...
  32. ncbi A novel glycosylated Cu/Zn-containing superoxide dismutase: production and potential therapeutic effect
    M Angelova
    Institute of Microbiology, Bulgarian Academy of Sciences, 26 Academician G. Bonchev, 1113 Sofia, Bulgaria
    Microbiology 147:1641-50. 2001
    ....
  33. pmc Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein F as a candidate
    Tiyun Wu
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Building 4, Room 329, 4 Center Drive, Bethesda, MD 20892 0460, USA
    J Virol 76:2279-86. 2002
    ....
  34. ncbi Prolonged E55+ retrovirus expression in aged mice is associated with a decline in the anti-virus immune response
    M Elrefaei
    Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Virology 290:281-9. 2001
    ..04 and P < 0.02, respectively). These results demonstrate that the observed delay in E55+ MuLV clearance by aged mice is associated with an age-related decrease in the immune response to the virus...
  35. pmc Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice
    Ingunn M Stromnes
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases NIH, Hamilton, Montana 59840, USA
    J Virol 76:2225-32. 2002
    ..Eventually, all of the IFN-gamma-deficient mice failed to keep persistent virus in check and developed fatal FV-induced erythroleukemia...
  36. pmc Preinfection treatment of resistant mice with CpG oligodeoxynucleotides renders them susceptible to friend retrovirus-induced leukemia
    Anke R M Olbrich
    Institut für Virologie der Universität Würzburg, 97078 Wurzburg, Germany
    J Virol 77:10658-62. 2003
    ....
  37. pmc Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line
    Janet W Hartley
    Laboratory of Immunopathology, NIAID, NIH, Bethesda, MD 20892, USA
    Retrovirology 5:1. 2008
    ....
  38. ncbi Kinetics of CD8+ effector T cell responses and induced CD4+ regulatory T cell responses during Friend retrovirus infection
    Gennadiy Zelinskyy
    Institut fuer Virologie des Universitaetsklinikums Essen, Essen, Germany
    Eur J Immunol 36:2658-70. 2006
    ..Transfer as well as depletion experiments indicated that regulatory CD4+ cells developed during the second week of FV infection and subsequently suppressed CD8+ T cell functions, which was associated with impaired virus clearance...
  39. pmc Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892 0460, USA
    Retrovirology 5:2. 2008
    ..Because M. dunni cells carry a variant CAT-1 cell surface virus receptor (dCAT-1), we examined the role of this receptor variant in cytopathicity and host range...
  40. pmc Activation of an oncogenic microRNA cistron by provirus integration
    Clifford L Wang
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:18680-4. 2006
    ..Our results demonstrate that retroviral mutagenesis can be a potent tool for miRNA discovery...
  41. ncbi Immune control and prevention of chronic Friend retrovirus infection
    Kim J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Front Biosci 12:1544-51. 2007
    ..Also summarized are findings from vaccine studies demonstrating the immunological requirements for the prevention of chronic retroviral infection. The implications of these findings for chronic infections in humans are discussed...
  42. ncbi CpG oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection
    Anke R M Kraft
    Institute for Virology, University of Duisburg Essen, Essen, Germany
    Blood 109:2982-4. 2007
    ..Thus, the transferred T cells were able to reduce chronic viral loads when combined with CpG-ODNs. This strategy provides a new approach for developing successful adoptive T-cell therapy against chronic infections...
  43. ncbi Enhancer mutations of Akv murine leukemia virus inhibit the induction of mature B-cell lymphomas and shift disease specificity towards the more differentiated plasma cell stage
    Karina Dalsgaard Sørensen
    Department of Molecular Biology, University of Aarhus, C F Møllers Alle, Bldg 130, DK 8000 Aarhus C, Denmark
    Virology 362:179-91. 2007
    ..Our results indicate that enhancer mutations weaken the ability of Akv to induce mature B-cell lymphomas prior to the plasma cell stage, whereas development of plasma cell proliferations is less dependent of viral enhancer strength...
  44. pmc A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection
    Shuang Ni
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802 3500, USA
    Mol Cell Biol 27:3708-15. 2007
    ....
  45. ncbi Cross-species infectivity and pathogenesis of the Friend murine leukemia virus complex in Syrian hamsters
    Xiaobei Chen
    Department of Microbiology, Pathology, Harbin Medical University, Bio Pharmacological Key Laboratory, Heilongjiang Province 150086, China
    Virus Res 130:281-4. 2007
    ..These findings suggest the potential danger of the interspecies transmission and pathogenesis of heterologous retroviruses in humans...
  46. pmc Friend virus utilizes the BMP4-dependent stress erythropoiesis pathway to induce erythroleukemia
    Aparna Subramanian
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Virol 82:382-93. 2008
    ..These observations suggest a novel mechanism by which a virus induces a stress response pathway that amplifies target cells for the virus, leading to acute expansion of infected cells...
  47. pmc Importance of receptor usage, Fli1 activation, and mouse strain for the stem cell specificity of 10A1 murine leukemia virus leukemogenicity
    Michaela Rodenburg
    Heinrich Pette Institut, Hamburg, Germany
    J Virol 81:732-42. 2007
    ..In summary, we validate the significance of the env gene in leukemia specificity and underline the importance of a complex interplay of cooperating oncogenes and/or tumor suppressors in determining the pathogenicity of MuLV variants...
  48. pmc Effects of type I interferons on Friend retrovirus infection
    Nicole Gerlach
    Institut für Virologie des Universitätsklinikum Essen, Universitat Duisburg Essen, 45122 Essen, Germany
    J Virol 80:3438-44. 2006
    ..These findings indicate that type I IFN plays an important role in the immediate antiviral defense against Friend retrovirus infection...
  49. pmc Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo
    Eri Takeda
    Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 82:10998-1008. 2008
    ..These results indicate, for the first time, that mouse APOBEC3 is a physiologically functioning restriction factor to mouse gammaretroviruses...
  50. ncbi Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility
    Aparna Subramanian
    Graduate Program in Biochemistry, Microbiology and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Leuk Res 30:1141-9. 2006
    ..Our data show that Lyn signals are not required for susceptibility to Friend erythroleukemia, but Lyn plays a role in later events, the terminal differentiation of infected cells and the expansion of transformed cells...
  51. ncbi Cuttine edge: T cells from aged mice are resistant to depletion early during virus infection
    Jiu Jiang
    Departments of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, PA 19129, USA
    J Immunol 171:3353-7. 2003
    ..These results indicate that both environmental and intrinsic cellular properties limit depletion of T cells of aged mice and suggest a novel explanation for the decreased T cell response associated with aging...
  52. ncbi Ecotropic murine leukemia viruses and exogenous mouse mammary tumor viruses are not essential for pristane-induced lupus
    Jun Akaogi
    University of Florida, Gainesville, FL, USA
    Arthritis Rheum 48:2990-2. 2003
  53. ncbi Genetic control of myeloproliferation in BXH-2 mice
    Karine Turcotte
    Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6
    Blood 103:2343-50. 2004
    ..Our results suggest a model in which Myls-dependent myeloproliferation in BXH-2 acts as a predisposing factor for the subsequent development of virally induced myeloid leukemia characteristic of this strain...
  54. ncbi Effects of tacrolimus on infection of Friend murine leukemia virus to Fv-4 gene heterozygous mice
    Feng Min Zhang
    Department of Microbiology, Harbin Medical University, Harbin 150086, China
    Acta Pharmacol Sin 25:208-12. 2004
    ..To investigate the effect of tacrolimus (FK506) on the infection of Friend murine leukemia virus (Friend MuLV) in vivo...
  55. pmc Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection
    Ronald J Messer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:12260-5. 2004
    ..These results emphasize the importance of inducing both T cell responses and virus-neutralizing antibody responses for effective retroviral vaccine protection...
  56. ncbi Cytological basis for enhancement of radiation-induced mortality by Friend leukaemia virus infection
    K Tanaka
    Radiation Hazards Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage, Chiba 263 8555, Japan
    Int J Radiat Biol 80:673-81. 2004
    ..To analyse the cytological basis for enhancement of radiation-induced mortality by Friend leukaemia virus infection...
  57. ncbi Direct transcriptional regulation of MDM2 by Fli-1
    Amandine H L Truong
    Department of Medical Biophysics, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada M4N 3M5
    Oncogene 24:962-9. 2005
    ..These observations depict a significant function of Fli-1 overexpression in the indirect control of p53, evidently capable of leading to an increasingly aggressive erythroleukemic clone in vivo...
  58. pmc A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus
    Sys Zoffmann Glud
    Department of Molecular Biology, University of Aarhus, Denmark
    Blood 106:3546-52. 2005
    ..These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3...
  59. pmc Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105 2794, USA
    Blood 107:73-8. 2006
    ..These results suggest that Friend virus activates both sf-STK and the EPOR to cause deregulated erythroid proliferation and differentiation...
  60. ncbi Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease
    Hiroyuki Kawabata
    Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Int Immunol 18:183-98. 2006
    ....
  61. ncbi [Oncogenes and leukemia: history and perspectives]
    Sylvie Gisselbrecht
    Département d Hématologie de l Institut Cochin, INSERM U 567, CNRS UMR 8104, bâtiment Gustave Roussy, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Med Sci (Paris) 19:201-10. 2003
    ..Treatment of leukemia could therefore benefit from new therapeutic approaches targeting the function of specific oncogene products as already demonstrated for CML and acute promyelocytic leukemia...
  62. pmc A non-coding cationic lipid DNA complex produces lasting anti-leukemic effects
    Nikki Keasey
    Penn State College of Medicine, Hershey, PA, USA
    Cancer Biol Ther 10:625-31. 2010
    ..This work demonstrates the effectiveness of CLDC in multiple experimental leukemias and is consistent with a stimulation of a lasting TH(1) anti-leukemic immune response...
  63. ncbi Assessing the potential leukemogenic effects of 50 Hz magnetic fields and their harmonics using an animal leukemia model
    Natacha Bernard
    Laboratoire d hématologie cellulaire et moléculaire, UFR des Sciences Pharmaceutiques et Biologiques, Paris, France
    J Radiat Res 49:565-77. 2008
    ..Our results do not support the hypothesis that ELF-MFs, with or without harmonics, affect the development of B acute lymphoblastic leukemia in children...
  64. ncbi A new zebrafish model for experimental leukemia therapy
    Igor V Mizgirev
    Feinberg School of Medicine, Northwestern University, Chicago, IL, USA N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cancer Biol Ther 9:895-902. 2010
    ..Therefore, this model can be utilized as a cost effective system for experimental tumor therapy and large-scale screening of anticancer compounds...
  65. pmc Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species
    Philip G Penketh
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Leuk Res 32:1546-53. 2008
    ..The numbers of cross-links produced in three experimental leukemia lines (L1210, U937 and HL-60) were fewer than 10 per genome at their respective LC50 concentrations...
  66. ncbi HTLV-1 cell lines differ in constitutively activated signaling pathways that can be altered by cytokine exposure
    W Liang
    Molecular and Cellular Immunogenetics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 290:91-8. 2001
    ..between one, RH/K30, that mediates asymptomatic infection and another, RH/K34, that causes lethal experimental leukemia. Both lines are IL-2 independent; RH/K30 produces IL-4 while RH/K34 produces IL-10...
  67. ncbi Squalenoyl nanomedicines as potential therapeutics
    Patrick Couvreur
    Univ Paris Sud XI, Faculte de Pharmacie, UMR CNRS 8612, IFR 141, 92296 Chatenay Malabry Cedex, France
    Nano Lett 6:2544-8. 2006
    ..activity in vitro in human cancer cells and gemcitabine-resistant murine leukemia cells, and in vivo in experimental leukemia both after intravenous and oral administration...
  68. ncbi Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice
    L Harivardhan Reddy
    Faculte de Pharmacie, Unité Mixte de Recherche Centre National de la Recherche Scientifique 8612, Institut Fédératif de Recherche 141, Universite Paris XI, Chatenay Malabry Cedex, France
    Drug Metab Dispos 36:1570-7. 2008
    ..Herein, this paper brings comprehensive pharmacokinetic and biodistribution insights that may explain the previously observed greater efficacy of SQdFdC nanoassemblies against experimental leukemia.
  69. ncbi Cytogenetic studies on abelson-virus-induced mouse leukemias
    G Klein
    Department of Tumor Biology, Karolinska Institutet, S 104 01 Stockholm 60, Sweden
    Int J Cancer 25:805-11. 1980
    ....
  70. ncbi Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y)
    K R Johnson
    Program in Genetics and Cell Biology, Washington State University, Pullman 99164
    J Biol Chem 263:18338-42. 1988
    ....
  71. ncbi SUSCEPTIBILITY AND RESISTANCE TO VIRAL LEUKEMOGENESIS IN THE MOUSE. I. BIOLOGIC DEFINITION OF THE VIRUS
    J R TENNANT
    J Natl Cancer Inst 34:625-32. 1965
  72. ncbi Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man
    Shimon Slavin
    The Danny Cunniff Leukemia Research Laboratory, Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital, Jerusalem 91120, Israel
    Crit Rev Oncol Hematol 46:139-63. 2003
    ....
  73. ncbi [Effects of NKG2D and its ligands RAE-1 and H60 on graft-versus-tumor response]
    Xiao Feng Li
    Department of Oncology, Quanzhou Hospital for Traditional Chinese Medicine, Quanzhou 362000, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:160-4. 2007
    ..It is concluded that NKG2D and its ligands RAE-1 and H60 may play important roles in GVT response...
  74. ncbi Adrenocortical lipid depletion and leukemia in mice
    K Arnesen
    Acta Pathol Microbiol Scand Suppl . 1974
  75. pmc Both the changes of six amino acids and the C-terminal truncation caused by a one-base insertion in the defective env gene of Friend spleen focus-forming virus significantly affect the pathogenic activity of the encoded leukemogenic membrane glycoprotein
    N Watanabe
    Laboratory of Gene Technology and Safety, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    J Virol 69:7606-11. 1995
    ..Analyses of the cellular processing of these mutant gp55s supported a correlation between the pathogenic activity of gp55 and its efficiency in overall cellular processing...
  76. pmc Isolation of new oncogenic forms of the murine c-fms gene
    N de Parseval
    Hopital Cochin, Institut Cochin de Genetique Moleculaire, U 363 Institut National de la Santé et de la Recherche Médicale, Universite Paris V, France
    J Virol 69:3597-604. 1995
    ..Donner, L. A. Fedele, C. F. Garon, S. J. Anderson, and C. J. Sherr, J. Virol. 41:489-500, 1982). The high rate of c-fms rearrangement and its relevance in the occurrence of hematopoietic tumors are discussed...
  77. ncbi BCL-2 expression and mitochondrial activity in leukemic cells with different sensitivity to glucocorticoid-induced apoptosis
    L A Smets
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
    Blood 84:1613-9. 1994
    ..Increased mitochondrial activity and (overexpressed) BCL-2 appeared closely related properties of glucocorticoid-resistant cells, sharing common cellular targets in hormone-induced apoptosis...
  78. pmc A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid progenitor cells
    G D Longmore
    Department of Medicine, Washington University, St Louis, Missouri 63110
    Mol Cell Biol 14:2266-77. 1994
    ..The sites of proviral integration in clonal cell lines are distinct from those in SFFV-derived lines...
  79. ncbi Genetic mapping of Pim-1 putative oncogene to mouse chromosome 17
    J Hilkens
    Somat Cell Mol Genet 12:81-8. 1986
    ..The Pim-1 gene was localized on chromosome 17, a chromosome frequently aberrant in T-cell lymphomas. Two chromosomal regions, containing sequences homologous to regions within the Pim-1 locus, were localized on chromosome 6 and 16...
  80. pmc B lymphocyte activation by coinfection prevents immune control of friend virus infection
    Rute Marques
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, London, United Kingdom
    J Immunol 181:3432-40. 2008
    ..Thus, immune activation by coinfecting pathogens or their products can contribute to the pathogenicity of retroviral infection...
  81. ncbi 5-aminolevulinic acid-based photodynamic therapy in leukemia cell HL60
    Su Juan Zhang
    Institute of Biomedical Engineering, School of Life Science and Technology, Xi an Jiaotong University, Xi an, China
    Photochem Photobiol 79:545-50. 2004
    ..Therefore a hypothetical idea can be brought forward that ALA-based PDT can be used for inactivation of leukemia cell HL60 and these optimal parameters may be useful for clinical application...
  82. ncbi Inhibitory effect of fulvic acid extracted from Canadian sphagnum peat on chemical mediator release by RBL-2H3 and KU812 cells
    Parida Yamada
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Biosci Biotechnol Biochem 71:1294-305. 2007
    ..Our results show that CP-FA may be useful for the treatment or prevention of allergic diseases...
  83. ncbi Monophosphoric acid diesters of 7 beta-hydroxycholesterol and of pyrimidine nucleosides as potential antitumor agents: synthesis and preliminary evaluation of antitumor activity
    Y H Ji
    Laboratoire de Chimie Organique des Substances Naturelles, URA CNRS No 31, Strasbourg, France
    J Med Chem 33:2264-70. 1990
    ..These compounds were screened for their antiproliferative activity toward EL-4 murine leukemia cells in vitro and for their antitumor activity against the mice bearing Krebs II ascitic carcinoma in vivo...
  84. pmc Structural analysis of TL genes of the mouse
    Y Obata
    Proc Natl Acad Sci U S A 82:5475-9. 1985
    ..1 has been deduced from the structure of pTL1+ cDNA clones and from the known organization of H-2 genes. The major structural differences between TL and H-2 genes are in exons coding for the cytoplasmic domain...
  85. ncbi Significant differences in therapeutic responses to a human interferon-alpha B/D hybrid in Rauscher or Friend murine leukemia virus infections
    J D Gangemi
    Research Laboratories, Pharmaceuticals Division, Ciba Geigy Ltd, Basel, Switzerland
    J Interferon Res 9:275-83. 1989
    ....
  86. ncbi Murine models for antiretroviral therapy
    R M Ruprecht
    Dana Farber Cancer Institute, Boston, Mass 02115
    Intervirology 30:2-11. 1989
    ..This model can also be used to study therapeutic approaches to retroviral infections acquired at midgestation or during the neonatal period...
  87. pmc SV7, a molecular clone of Moloney murine sarcoma virus 349, transforms vascular endothelial cells
    P H Yuen
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957
    Am J Pathol 139:1449-61. 1991
    ..The latter manifested a more advanced myeloid metaplasia, characterized by aggregates of myelomonocytic blast cells in the spleen...
  88. ncbi Naturally occurring leukaemia viruses in wild mice: how good a model for humans?
    M B Gardner
    Department of Medical Pathology, University of California, Davis 95616
    Cancer Surv 6:55-71. 1987
    ..These results illustrate the importance of studying natural history in the 'real world' and the limitations of laboratory artefacts such as those created by inbreeding of laboratory mice...
  89. ncbi Host genetic factors that control immune responses to retrovirus infections
    Masaaki Miyazawa
    Department of Immunology, Kinki University School of Medicine, Osaka 589 0023, Japan
    Vaccine 26:2981-96. 2008
    ..Recent genetic analyses have indicated that a large proportion of such exposed but uninfected individuals may share a common genetic background...
  90. ncbi The antitumour effect of lipophilic derivatives of 5-fluoro-2'-deoxyuridine incorporated into liposomes
    A Supersaxo
    Department of Physical Pharmacy, Swiss Federal Institute of Technology,
    J Microencapsul 5:1-11. 1988
    ..A further increase of the antitumour activity may be obtained by the attachment of tumour-specific antibodies to the surface of such prodrug-containing liposomes...
  91. ncbi Commitment to erythroid differentiation in mouse erythroleukemia cells is controlled by alterations in topoisomerase II alpha phosphorylation
    A I Constantinou
    University of Illinois at Chicago, College of Medicine, Department of Surgical Oncology 60612, USA
    Cancer Res 56:4192-9. 1996
    ..Structural changes in chromatin became evident in sensitive cells 24 h after HMBA treatment, suggesting that alterations in topo II alpha phosphorylation may control cell differentiation by altering nuclear architecture...
  92. ncbi Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life span
    N L Currier
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    J Altern Complement Med 7:241-51. 2001
    ..The profoundly positive effects of this herb in disease abatement observed in this study suggest the therapeutic potential of E. purpurea, at least with respect to leukemia, if not other tumors as well...
  93. pmc Murine Ly-6 multigene family is located on chromosome 15
    K P LeClair
    Proc Natl Acad Sci U S A 84:1638-42. 1987
    ..The possible involvement of the Ly-6 lymphocyte activation and differentiation antigen genes in chromosome 15-related lymphoid malignancies is discussed...
  94. ncbi IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1
    J Lee
    Department of Molecular Biology, Genentech Inc, San Francisco, California 94080, USA
    J Biol Chem 276:1660-4. 2001
    ..IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8...
  95. pmc Critical role for CD4(+) T cells in controlling retrovirus replication and spread in persistently infected mice
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 72:6559-64. 1998
    ....
  96. pmc Both the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus induce constitutive activation of the Raf-1/mitogen-activated protein kinase signal transduction pathway
    K W Muszynski
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    J Virol 72:919-25. 1998
    ....
  97. ncbi Leukemic predisposition of pSca-1/Cb2 transgenic mice
    Marieke Joosten
    The Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Exp Hematol 30:142-9. 2002
    ..To determine the effect of Cb2 overexpression on hematopoietic development in vivo, Cb2 transgenic mice were generated...
  98. pmc Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection
    U Dittmer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 75:654-60. 2001
    ..The results indicate that IFN-gamma plays an important role during primary immune responses against Friend virus but is dispensable during vaccine-primed secondary responses...
  99. ncbi Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue
    S Avraham
    Department of Medicine, Harvard Medical School, Boston, Massachusetts
    J Biol Chem 263:7292-6. 1988
    ..Analysis of 10 different mouse/hamster somatic cell hybrid lines with a SspI----3' fragment of the rat L2 cell cDNA revealed that, as in the human, the gene that encodes the mouse analogue of this peptide core resides on chromosome 10...
  100. ncbi Induction of leukemia in mice using a radiation leukemia virus-induced cell line: a model system for studying oncogenic progression
    E S Ho
    Molecular Immunology Laboratory, John Curtin School of Medical Research, Canberra, ACT, Australia
    Leuk Res 19:83-93. 1995
    ..This new model for oncogenic progression should be more amenable to analysis of early genetic changes occurring during replication of leukemia in the thymus...
  101. ncbi Extension of the H-2 TLb molecular map. Isolation and characterization of T13, T14, and T15 from the C57BL/6 mouse
    G D Brown
    Department of Pathology, New York University Medical Center, NY 10016
    Immunogenetics 27:239-51. 1988
    ..The diversity seen in the T13-T15 region may provide insights into the phenotypic expression or regulatory mechanisms of TL expression in these two haplotypes...

Research Grants31

  1. LIPOPHILIC PROBES FOR TUMOR CELL SURFACES
    Fritz Sieber; Fiscal Year: 1990
    ..Although MC 540-mediated photosensitization reduces the concentration of experimental leukemia cells greater than 100,000-fold without excessive damage to the pluripotent stem cell compartment, it may ..
  2. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
    ..The results of these studies will enhance our understanding of the role of apoptosis in the development of neoplastic disease. ..
  3. Selective in vivo Ablation of Leukemia Stem Cells
    Craig Jordan; Fiscal Year: 2009
    ..Collectively, the proposed studies will provide a detailed evaluation of how therapeutic agents impact the growth and survival of LSC in vivo. ..
  4. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2005
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  5. Cellular and Molecular Studies of Leukemic Stem Cellss
    Craig Jordan; Fiscal Year: 2006
    ..Collectively, these efforts will advance our understanding of basic mechanisms that underlie leukemic transformation and will improve strategies for the preferential ablation of LSCs. ..
  6. Amnis ImageStream Flow Cytometer
    Craig Jordan; Fiscal Year: 2007
    ..Taken together, the unique capabilities of the ImageStream system will therefore serve to strongly benefit a wide range of research activities. [unreadable] [unreadable] [unreadable]..
  7. Search for the Molecular Targets of Phenols
    CYNTHIA SELASSIE; Fiscal Year: 2006
    ..It is envisioned that the combined experimental-computational approach to phenol toxicity will provide guidance for the inclusion or exclusion of the OH group from new drug entities. [unreadable] [unreadable]..
  8. mTOR Signaling In Chronic Myelogenous Leukemia
    Hung Fan; Fiscal Year: 2009
    ..abstract_text> ..
  9. Screen for Mycobacterium Tuberculosis (RMI)
    E White; Fiscal Year: 2005
    ..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
  10. ISOLATION OF THE NEUROBLASTOMA PREDISPOSITION GENE
    John Maris; Fiscal Year: 2006
    ..Ultimately, these experiments should lead to the identification of a common pathway to neuroblastoma tumorigenesis that will be an outstanding target for rationally designed therapeutics. ..
  11. Mechanisms of IL-18 Mediated Regulation of GVHD and GVL
    Pavan Reddy; Fiscal Year: 2006
    ..The applicant's sponsor guarantees that 80% of Dr. Reddy's effort will be devoted to his research during this award. ..
  12. Significance of Genetic Alterations in Neuroblastoma
    John Maris; Fiscal Year: 2006
    ..It is expected that these will be of prognostic importance and serve as specific targets for developmental therapeutics. ..
  13. Gene Delivery into Human Hematopoietic Cells
    Arthur Bank; Fiscal Year: 2008
    ..The gene delivery technology should also be applicable for use in treating other human diseases as well. ..
  14. Murine models of activated FLT3 receptor tyrosine kinase
    Benjamin Lee; Fiscal Year: 2007
    ....
  15. Mechanisms of Leukocyte Recruitment During IPS After BMT
    Kenneth Cooke; Fiscal Year: 2007
    ..lymphocytes --> days 7-21 SA2: CXCR3 / IP-10 (CXCL10) and Mig (CXCL9) SA3: CCR2: / MCP-1 (CCL2) --> monocytes/macrophages --> days 14-28 SA4:CXCR2 / KC and MIP-2 (CXCL1) --> neutrophils --> days 21 to 42 ..
  16. Role of the STK Receptor in Erythropoiesis
    Pamela Hankey; Fiscal Year: 2009
    ....
  17. CHEMOPROT OF HEMATOPOIETIC CELLS BY MDR GENE TRANSFER
    Arthur Bank; Fiscal Year: 2001
    ..These studies could lead to conditions for permitting higher doses of chemotherapy to be administered to advanced cancer patients with less hematologic toxicity, longer remissions or potential cure of these patients. ..
  18. MURINE STK RECEPTOR AND MACROPHAGE ACTIVATION
    PAMELA CORRELL; Fiscal Year: 2002
    ..By understanding, in more detail, the regulation of macrophage activation, the PI hopes to begin to identify targets for suppression of the tissue-damaging effects of inflammation without compromising the host immune response. ..
  19. Novel Immune Modulation in AIDS and AIDS Malignancy
    Michael Caligiuri; Fiscal Year: 2002
    ..The overall objective of this application is to characterize the immunologic consequences of this innate immune modulation to better understand how to compensate for antigen-specific immune deficiency. ..
  20. CHEMOPREVENTION OF MAMMARY TUMORS BY TAMOXIFEN AND SOY
    Andreas Constantinou; Fiscal Year: 2002
    ..2) Identify the mechanism of the anticipated additive/synergistic chemopreventive effect between tamoxifen and the active soy component. ..
  21. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2002
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
  22. HUMAN GLOBIN GENE TRANSFER AND EXPRESSION
    Arthur Bank; Fiscal Year: 2002
    ....
  23. MOLECULAR BIOLOGY OF JAAGSIEKTE SHEEP RETROVIRUS
    Hung Fan; Fiscal Year: 2003
    ..These experiments will provide insight into JSRV-induced lung cancer in sheep, and possibly into human BAC. ..
  24. Mechanism(s)of antitumor action of tamoxifen and soy
    Andreas Constantinou; Fiscal Year: 2003
    ..This study will systematically explore their interactions to determine their safety and efficacy. ..
  25. REGULATION OF HUMAN GLOBIN GENE EXPRESSION
    Arthur Bank; Fiscal Year: 2004
    ..abstract_text> ..
  26. EXPRESSION AND PATHOGENESIS OF MURINE LEUKEMIA VIRUS
    Hung Fan; Fiscal Year: 2005
    ..low expression. Together, these experiments will provide new and important insights into leukemogenesis by MuLVs. ..
  27. MISSING DATA, MEASUREMENT ERROR AND APPLICATIONS
    Ching Yun Wang; Fiscal Year: 2002
    ..The investigator states that the proposed methods will also accommodate two-stage designs which are becoming popular in epidemiologic research and particular in genetic epidemiology. ..
  28. Transduction of Tumor Suppressor Proteins into Gliomas
    STEVEN DOWDY; Fiscal Year: 2005
    ..TAT-TK activity will also be monitored in vivo by microPET imaging using '8F-fluoroganciclovir as a positron emitter. ..