Genomes and Genes
Summary: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications388 found, 100 shown here
- Prognostic effect of re-excision in adult soft tissue sarcoma of the extremityMarco Fiore
Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian, 1, Milan, 20133, Italy
Ann Surg Oncol 13:110-7. 2006We explored the outcome of patients with primary adult soft tissue sarcoma (STS) of the extremities undergoing re-excision after previous unplanned surgery.
- Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapyJordi Barretina
Department of Medical Oncology, Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 42:715-21. 2010..Our study yields a detailed map of molecular alterations across diverse sarcoma subtypes and suggests potential subtype-specific targets for therapy.
- Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcomaBirgit Lohberger
Department of Orthopaedic Surgery, Medical University of Graz, Graz, Austria
PLoS ONE 7:e43664. 2012..assay and fluorescence-activated cell sorting (FACS) analysis to isolate ALDH1(high) cells from five human sarcoma cell lines and one primary chordoma cell line. ALDH1(high) cells range from 0.3% (MUG-Chor1) to 4...
- Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trialWinette T A van der Graaf
Radboud University Medical Centre, Department of Medical Oncology, Nijmegen, Netherlands
Lancet 379:1879-86. 2012..tyrosine kinase inhibitor, has single-agent activity in patients with advanced non-adipocytic soft-tissue sarcoma. We investigated the effect of pazopanib on progression-free survival in patients with metastatic non-adipocytic ..
- Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002 [corrected]Robert G Maki
Department of Medicine, Memorial Sloan Kettering Cancer Center New York, NY 10021, USA
J Clin Oncol 25:2755-63. 2007..agent and the combination of gemcitabine and docetaxel have activity in patients with metastatic soft tissue sarcoma. To determine if the addition of docetaxel to gemcitabine improved clinical outcome of patients with metastatic ..
- Diagnosis of gastrointestinal stromal tumors: A consensus approachChristopher D M Fletcher
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
Hum Pathol 33:459-65. 2002....
- High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25ASapna Vijayakumar
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
Cancer Cell 19:601-12. 2011..We show here that 50% of human sarcomas (n = 45) and 65% of sarcoma cell lines (n = 23) of diverse histological subtypes exhibit upregulated autocrine canonical Wnt signaling...
- Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumorsRichard Quek
Center for Sarcoma and Bone Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Clin Cancer Res 17:871-9. 2011..Pharmacokinetics and preliminary antitumor effects of the combination were evaluated...
- Soft-tissue sarcomas in adultsMatthew A Clark
Sarcoma Unit, the Royal Marsden Hospital National Health Service Foundation Trust, London
N Engl J Med 353:701-11. 2005
- The insulin-like growth factor system and sarcomasBart Rikhof
Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, The Netherlands
J Pathol 217:469-82. 2009..growth factor (IGF) signalling system in the cellular transformation and progression of several types of sarcoma, including rhabdomyosarcoma, synovial sarcoma, leiomyosarcoma, Ewing's sarcoma and osteosarcoma...
- Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcomaJan Ahlén
Department of Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
Clin Cancer Res 11:206-16. 2005..To evaluate known and suggested prognostic markers, especially insulin-like growth factor type 1 receptor (IGF-1R), in highly malignant soft tissue sarcomas (STS)...
- Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testingFrançoise Ducimetière
Universite de Lyon, Cancer Centre Léon Bérard, EA 4129, Lyon, France
PLoS ONE 6:e20294. 2011The exact overall incidence of sarcoma and sarcoma subtypes is not known...
- Cutaneous soft tissue sarcoma incidence patterns in the U.S. : an analysis of 12,114 casesPanta Rouhani
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7231, USA
Cancer 113:616-27. 2008..Cutaneous soft tissue sarcomas (CSTS) are a heterogeneous group of mesenchymal neoplasms. To the authors' knowledge, no prior large, population-based study has focused on CSTS...
- NVP-BEZ235 as a new therapeutic option for sarcomasMaria C Manara
Laboratorio di Ricerca Oncologica, Istituto Ortopedico Rizzoli, Bologna, Italy
Clin Cancer Res 16:530-40. 2010To evaluate the in vitro and in vivo effects of NVP-BEZ235, a dual pan-phosphoinositide 3-kinase-mammalian target of rapamycin inhibitor in the three most common musculoskeletal tumors (osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma).
- CCNU for the treatment of dogs with histiocytic sarcomaKatherine A Skorupski
Departments of Clinical Studies, Matthew J Ryan Veterinary Hospital, University of Pennsylvania Philadelphia, USA
J Vet Intern Med 21:121-6. 2007Histiocytic sarcoma is an aggressive neoplasm of dendritic cells that carries a grave prognosis. The efficacy of chemotherapy against this disease is unknown...
- Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosisMarianne Kraus
Department of Medicine II, University of Tubingen, Tubingen, Germany
Mol Cancer Ther 7:1940-8. 2008..Most solid malignancies such as sarcoma, by contrast, are poorly bortezomib sensitive and display low levels of ER stress...
- MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st CenturyIgor Matushansky
Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
Expert Rev Anticancer Ther 9:1135-44. 2009..Originally characterized as a morphologically unique soft-tissue sarcoma subtype of unclear etiology in 1963, with a following 15 years of research only to conclude that "the issue of ..
- Activity of eribulin mesylate in patients with soft-tissue sarcoma: a phase 2 study in four independent histological subtypesPatrick Schoffski
University Hospitals Leuven, Catholic University Leuven, Department of General Medical Oncology, Leuven Cancer Institute, Leuven, Belgium
Lancet Oncol 12:1045-52. 2011..We assessed the activity and safety of eribulin in four strata of patients with different types of soft-tissue sarcoma.
- Testing new regimens in patients with advanced soft tissue sarcoma: analysis of publications from the last 10 yearsN Penel
European Organisation for Research and Treatment of Cancer Headquarters, EORTC, Brussels, Belgium
Ann Oncol 22:1266-72. 2011The prognosis of advanced soft tissue sarcoma remains poor. Many phase II trials investigating new regimens have been published in the last 10 years.
- Langerhans cell sarcoma arising from Langerhans cell histiocytosis: a case reportJong Sil Lee
Department of Pathology, College of Medicine, Gyeongsang National University, Jinju, Korea
J Korean Med Sci 21:577-80. 2006Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells that have overtly malignant cytologic features...
- p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasionGustavo Baldassarre
Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy
Cancer Cell 7:51-63. 2005..This study provides a functional link between proliferation and invasion of tumor cells based on diverse activities of p27(kip1) in different subcellular compartments...
- Uterine sarcomas: a reviewEmanuela D'Angelo
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Sant Antoni M Claret, 167, 08025 Barcelona, Spain
Gynecol Oncol 116:131-9. 2010..Currently, there is no consensus on risk factors for adverse outcome. This review summarizes the available clinicopathological data on uterine sarcomas classified by the WHO diagnostic criteria...
- Sarcoma as a second malignancy after treatment for breast cancerJohnny Yap
Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI, USA
Int J Radiat Oncol Biol Phys 52:1231-7. 2002..neoplasms in breast cancer patients have been limited by the numbers of patients and relatively low incidence of sarcoma. Using data from the Surveillance, Epidemiology and End Results registries, we evaluated the influence of ..
- Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 620Stefan Sleijfer
Dept of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
J Clin Oncol 27:3126-32. 2009PURPOSE Given the importance of angiogenesis in soft tissue sarcoma (STS), pazopanib, an oral angiogenesis inhibitor that targets vascular endothelial growth factor receptor and platelet-derived growth factor receptor, was explored in ..
- Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasmsD Malkin
Division of Molecular Genetics, Massachusetts General Hospital Cancer Center, Charlestown 02129
Science 250:1233-8. 1990..The frequency of germ line p53 mutations can now be examined in additional families with LFS, and in other cancer patients and families with clinical features that might be attributed to the mutation...
- Opportunities for improving the therapeutic ratio for patients with sarcomaJay S Wunder
University Musculoskeletal Oncology Unit and Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
Lancet Oncol 8:513-24. 2007..Limb-sparing surgery delivered at specialised sarcoma centres as part of a multidisciplinary approach has become the standard treatment for most patients and usually ..
- Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort studyDavid Olmos
The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, Surrey, UK
Lancet Oncol 11:129-35. 2010..Preclinical data suggest a dependence on insulin-like growth-factor signalling for sarcoma subtypes, including Ewing's sarcoma, and early reports show antitumour activity of IGF-1R-targeting drugs in ..
- MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cellsJenny M Kreahling
Experimental Therapeutics Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Mol Cancer Ther 11:174-82. 2012..Here, we studied the cytotoxic effect of MK1775 in various sarcoma cell lines and patient-derived tumor explants ex vivo...
- Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trialA Le Cesne
Department of Medicine, Institut Gustave Roussy, 94805 Villejuif Cedex, France
J Clin Oncol 23:576-84. 2005..5 mg/m(2) as a 24-hour continuous infusion every 3 weeks in patients with pretreated advanced soft tissue sarcoma.
- Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistanceMary A Zimmerman
Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
Cancer Res 72:4724-32. 2012..Using a murine model of soft tissue sarcoma (STS), we show that disruption of the IFN effector molecule IRF8 decreases pSTAT1 and increases uSTAT1 in STS ..
- Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcomaJason L Hornick
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 33:542-50. 2009..Immunostaining for INI1 can be used to confirm the diagnosis of ES in the appropriate context. Loss of INI1 expression may also be helpful to distinguish epithelioid MPNST from metastatic melanoma in a subset of cases...
- High metastatic efficiency of human sarcoma cells in Rag2/gammac double knockout mice provides a powerful test system for antimetastatic targeted therapyPatrizia Nanni
Cancer Research Section, Department of Experimental Pathology, Viale Filopanti 22, University of Bologna, 40126 Bologna, Italy
Eur J Cancer 46:659-68. 2010..Metastatic spread of a panel of human sarcoma cell lines was studied in double knockout Rag2(-/-);gammac(-/-) mice in comparison with NK-depleted nude mice...
- The biology behind mTOR inhibition in sarcomaXiaolin Wan
Molecular Oncology Section, Pediatric Oncology Branch, Building 10, Room CRC 1W 3816, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1928, USA
Oncologist 12:1007-18. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- Therapeutic vulnerability of an in vivo model of alveolar soft part sarcoma (ASPS) to antiangiogenic therapyDavid T Vistica
Screening Technologies Branch, Developmental Therapeutics Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA
J Pediatr Hematol Oncol 31:561-70. 2009In vivo growth of alveolar soft part sarcoma (ASPS) was achieved using subcutaneous xenografts in sex-matched nonobese diabetic severe combined immunodeficiency mice...
- Biological rationale and current clinical experience with anti-insulin-like growth factor 1 receptor monoclonal antibodies in treating sarcoma: twenty years from the bench to the bedsideDavid Olmos
Sarcoma Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
Cancer J 16:183-94. 2010..Two decades have elapsed since insulin-like growth factor-1 receptor (IGF-1R) signaling was initially implicated in sarcoma biology to the first clinical experience of IGF-1R blockade in sarcoma...
- The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcomaRaushan T Kurmasheva
Departments of Molecular Pharmacology, Biostatistics, and Pathology, St Jude Children s Research Hospital, Memphis, TN38105, USA
Cancer Res 69:7662-71. 2009..CP-751,871, a human antibody that blocks IGF-1R ligand binding, alone and in combination with rapamycin against sarcoma cell lines in vitro and xenograft models in vivo...
- Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children's Cancer Group (CCG) experiencePatrick Van Winkle
Childrens Hospital of Los Angeles, Los Angeles, California, USA
Pediatr Blood Cancer 44:338-47. 2005..We determined the overall response rate (ORR) and overall survival (OS) of children with recurrent/refractory sarcomas who were given ifosfamide, carboplatin, and etoposide (ICE) in three Children's Cancer Group (CCG) phase I/II trials...
- Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkersAndrew H Beck
Pathology Department, Stanford University Medical Center, Stanford, CA 94305, USA
Virchows Arch 456:141-51. 2010..In the past decade, gene expression profiling has been applied to sarcomas to facilitate understanding of sarcoma pathogenesis and to identify diagnostic, prognostic, and predictive markers...
- Ether à go-go potassium channel expression in soft tissue sarcoma patientsFernanda Mello de Queiroz
Divisão de Farmacologia, Coordenação de Pesquisa, Instituto Nacional do Cancer, Rio de Janeiro, Brazil
Mol Cancer 5:42. 2006..Our purpose was to determine the frequency of expression of Eag1 in soft tissue sarcoma and its potential clinical implications.
- Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremitiesMargaret M Roebuck
Department of Musculoskeletal Science, University of Liverpool, Liverpool, England
Am J Clin Pathol 123:405-14. 2005..The activation of endothelial MMP-2 linked to widespread MMP-14 expression provides a mechanism for sarcomas to modulate their matrix and facilitate angiogenesis...
- Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trialJaap Verweij
Department of Medical Oncology, Erasmus University Medical Centre, Groene Hilledijk 301, 3075 EA Rotterdam, Netherlands
Lancet 364:1127-34. 2004..Imatinib is approved worldwide for use in gastrointestinal stromal tumours (GIST). We aimed to assess dose dependency of response and progression-free survival with imatinib for metastatic GIST...
- Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patientsA Yovine
Hopital St Louis, Unité d Oncologie Médicale, 1 av Claude Vellefaux, 75010 Paris, France
J Clin Oncol 22:890-9. 2004A multicenter phase II study evaluating efficacy, safety, and pharmacokinetics of ecteinascidin-743 (ET-743) in pretreated advanced soft tissue sarcoma patients.
- Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney triadJ Aidan Carney
Department of Laboratory Medicine and Pathology Emeritus member, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Am J Med Genet 108:132-9. 2002..with an average age of 23 years from five unrelated families that manifested paraganglioma and gastric stromal sarcoma; the tumors were inherited in an apparent autosomal dominant manner, with incomplete penetrance...
- Localized extremity soft tissue sarcoma: improved knowledge with unchanged survival over timeJurgen Weitz
Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
J Clin Oncol 21:2719-25. 2003The objective of this study was to define whether survival of patients with extremity soft tissue sarcoma (STS), stratified for known risk factors, has improved over the last 20 years.
- MicroRNA expression signature of human sarcomasS Subramanian
Department of Pathology, Stanford University, Stanford, CA 94305, USA
Oncogene 27:2015-26. 2008..Our data show that different histological types of sarcoma have distinct miRNA expression patterns, reflecting the apparent lineage and differentiation status of the tumors...
- Phenoxy herbicides and chlorophenols: a case control study on soft tissue sarcoma and malignant lymphomaJ G Smith
Statistical Centre, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
Br J Cancer 65:442-8. 1992A case control study on patients with soft tissue sarcoma and malignant lymphoma was undertaken to test whether there was any association between these diseases and past exposure to chlorinated phenoxy acid herbicides or chlorophenols...
- Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcomaD M Brizel
Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, North Carolina, 27710, USA
Cancer Res 56:941-3. 1996..was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmestastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and ..
- Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberansRobert G Maki
Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 6007, USA
Int J Cancer 100:623-6. 2002Dermatofibrosarcoma protuberans (DFSP) is a rare superficial sarcoma usually affecting the trunk, with significant risk of local recurrence...
- Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcomaBrian P Rubin
Department of Anatomic Pathology, Taussig Cancer Center and Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Cancer Cell 19:177-91. 2011..prenatal or postnatal myogenic cell of origin, we demonstrate that eRMS and undifferentiated pleomorphic sarcoma (UPS) lie in a continuum, with satellite cells predisposed to giving rise to UPS...
- Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcomaIvaylo Gentschev
Genelux Corporation, San Diego Science Center, San Diego, California, United States of America
PLoS ONE 7:e37239. 2012..In this study we describe the establishment of an in vivo model of canine soft tissue sarcoma (CSTS) using the new isolated cell line STSA-1 and the analysis of the virus-mediated oncolytic and immunological ..
- Adaptive immunity maintains occult cancer in an equilibrium stateCatherine M Koebel
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 450:903-7. 2007..These results reveal that, in addition to destroying tumour cells and sculpting tumour immunogenicity, the immune system of a naive mouse can also restrain cancer growth for extended time periods...
- A spatially and temporally restricted mouse model of soft tissue sarcomaDavid G Kirsch
Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Med 13:992-7. 2007..To explore mechanisms of sarcoma pathogenesis, we have generated a mouse model of soft tissue sarcoma...
- Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapyO Hans Iwenofu
Department of Pathology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, PA, USA
Mod Pathol 21:231-7. 2008..The level of phosphorylated S6 ribosomal protein expression was predictive of early tumor response to the mTOR inhibitor, suggesting that this is a promising new predictive sarcoma marker for targeted mTOR inhibitor therapy.
- Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and TrStefan Sleijfer
Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands
Eur J Cancer 46:72-83. 2010..As ifosfamide is frequently applied in first line systemic therapy, we aimed to establish prognostic and predictive factors for outcome to ifosfamide-based therapy...
- Ecteinascidin-743: a marine-derived compound in advanced, pretreated sarcoma patients--preliminary evidence of activityS Delaloge
, Villejuif, France
J Clin Oncol 19:1248-55. 2001PURPOSE: To report the activity of the chemotherapeutic agent ecteinascidin-743 (ET-743) in advanced pretreated sarcoma patients observed during a phase I study and a named-patient basis, compassionate use program...
- Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomasZ A Khatib
Department of Experimental Oncology and Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
Cancer Res 53:5535-41. 1993..which are frequently amplified in human sarcomas, we analyzed CDK4 copy number and expression in a panel of sarcoma cell lines...
- Prognostic significance of Wilms tumor gene (WT1) mRNA expression in soft tissue sarcomaTsukasa Sotobori
Department of Orthopedics, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
Cancer 106:2233-40. 2006..The objective of the current study was to evaluate the prognostic significance of WT1 mRNA expression in patients with soft tissue sarcoma.
- Mechanisms of sarcoma developmentLee J Helman
Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 13N240, MSC 1928, Bethesda, Maryland 20892 1928, USA
Nat Rev Cancer 3:685-94. 2003..It is likely that this approach will lead to continued refinements in classification and treatment of these tumours...
- Prospective study of thrombospondin-1 mimetic peptides, ABT-510 and ABT-898, in dogs with soft tissue sarcomaA I Sahora
The Oncology Service, LLC, Washington, DC, USA
J Vet Intern Med 26:1169-76. 2012..Exposure to anti-angiogenic thrombospondin-1 (TSP-1) mimetic peptides (MPs) has resulted in sporadic anti-tumor activity in humans and dogs...
- A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusionGaelle Pierron
Institut Curie, Unité de Génétique Somatique Centre Hospitalier, Paris, France
Nat Genet 44:461-6. 2012The identification of subtype-specific translocations has revolutionized the diagnostics of sarcoma and has provided new insight into oncogenesis...
- Spatial heterogeneity in sarcoma 18F-FDG uptake as a predictor of patient outcomeJanet F Eary
Division of Nuclear Medicine, Departments of Radiology and Orthopedic Surgery, University of Washington, Seattle, Washington, USA
J Nucl Med 49:1973-9. 2008..This study presents data to support the hypothesis that a new heterogeneity-analysis algorithm applied to (18)F-FDG PET images of tumors in patients is predictive of patient outcome...
- Validation of the prognostic relevance of plasma C-reactive protein levels in soft-tissue sarcoma patientsJ Szkandera
Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
Br J Cancer 109:2316-22. 2013..The aim of the present study was to validate the prognostic value of pre-operative plasma CRP levels on clinical outcome in a large cohort of soft-tissue sarcoma (STS) patients.
- Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcomaAndrew D Kelly
Division of Hematology Oncology, Sarcoma Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e25357. 2011..Our study supports the notion that reliable and broadly informative metabolomic data may be acquired from FFPE soft tissue sarcoma specimens, a finding that is likely to be extended to other malignancies.
- Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507Emmy D G Fleuren
Departments of Medical Oncology and Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Cancer Res 17:7693-703. 2011....
- Lymphadenectomy for isolated lymph node metastasis from extremity soft-tissue sarcomasWaddah B Al-Refaie
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77203 1402, USA
Cancer 112:1821-6. 2008..This study was performed to determine the outcomes of patients who underwent aggressive therapy, including lymphadenectomy in patients with LN metastasis from ESTS...
- Epithelioid sarcoma: Still an only surgically curable diseaseSebastiaan A H J de Visscher
Department of Surgical Oncology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
Cancer 107:606-12. 2006Epithelioid sarcoma is a rare soft tissue sarcoma with a known high propensity for locoregional recurrence and distant metastases...
- Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosisFrank Bartel
Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
Int J Cancer 117:469-75. 2005..In summary, our data indicate that both the overexpression of the HDMX-S transcript as well as HDMX gene amplification are important prognostic markers for STS...
- Use of 18F-fluorodeoxyglucose positron emission tomography for diagnosis of uterine sarcomasAkira Nagamatsu
Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama 641 8509, Japan
Oncol Rep 23:1069-76. 2010..In conclusion, FDG-PET is useful for diagnosing uterine sarcomas, while FDG-PET combined with serum LDH is useful for diagnosing LMS. Immunohistochemical examination of GLUT-1 confirmed the high FDG uptake in LMS patients...
- A synthetic cantharidin analog for the enhancement of doxorubicin suppression of stem cell-derived aggressive sarcomaChao Zhang
Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, 30 Gaotanyan Road, Chongqing 400038, China
Biomaterials 31:9535-43. 2010..PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention of ..
- Molecular genetics of sarcomas: applications to diagnoses and therapyJunya Toguchida
Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University
Cancer Sci 100:1573-80. 2009....
- Detection and grading of soft tissue sarcomas of the extremities with (18)F-3'-fluoro-3'-deoxy-L-thymidineDavid C P Cobben
Department of Surgical Oncology, Groningen University Hospital, Groningen, The Netherlands
Clin Cancer Res 10:1685-90. 2004The aim of the study was to investigate the feasibility of (18)F-3'-fluoro-3'-deoxy-L-thymidine positron emission tomography (FLT-PET) for the detection and grading of soft tissue sarcoma (STS).
- Prognosis of lymph node metastasis in soft tissue sarcomaKasim A Behranwala
Sarcoma and Melanoma Unit, Royal Marsden NHS Trust, 203 Fulham Road, London SW3 6JJ, UK
Ann Surg Oncol 11:714-9. 2004We defined the tumor characteristics and prognosis of patients with regional lymph node metastasis (RLNM) from soft tissue sarcoma.
- Fascaplysin exert anti-tumor effects through apoptotic and anti-angiogenesis pathways in sarcoma mice modelXiaojun Yan
Ningbo University, Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo, Zhejiang 315211, China
Eur J Pharm Sci 43:251-9. 2011..In order to verify these two effects in animal model and to identify action mechanisms, we established a sarcoma mice model, and treated mice with fascaplysin for 10 days...
- Appraising the current role of chemotherapy for the treatment of sarcomaDavid R D'Adamo
Sarcoma and Bone Cancer Treatment Center, Dana Farber Cancer Institute, Boston, MA 02215, USA
Semin Oncol 38:S19-29. 2011..They can be grouped into two general categories: soft tissue sarcoma (STS) and primary bone sarcoma, which are treated differently...
- The significance of a marginal excision after preoperative radiation therapy for soft tissue sarcoma of the extremityRoi Dagan
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA
Cancer 118:3199-207. 2012Marginal excision of soft tissue sarcoma (STS), defined as resection through the tumor pseudocapsule or surrounding reactive tissue, increases the likelihood of local recurrence and necessitates re-excision or postoperative radiation...
- A novel combined radiological method for evaluation of the response to chemotherapy for primary bone sarcomaShinji Miwa
Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan
J Surg Oncol 106:273-9. 2012In the treatment of bone sarcoma, evaluation of chemotherapeutic effects is extremely important...
- Long-term results of tumor necrosis factor alpha- and melphalan-based isolated limb perfusion in locally advanced extremity soft tissue sarcomasJan P Deroose
Daniel den Hoed Cancer Center, Erasmus MC, Rotterdam, The Netherlands
J Clin Oncol 29:4036-44. 2011..This study reports the long-term results of 231 TM-ILPs for locally advanced extremity STS...
- Systemic therapy for advanced soft tissue sarcomas: highlighting novel therapies and treatment approachesRichard F Riedel
Division of Medical Oncology, Duke University Medical Center, Durham, North Carolina, USA
Cancer 118:1474-85. 2012..This article provides an overview of current systemic therapies for patients with advanced STS and discusses ongoing efforts designed to improve patient outcomes through the use of novel therapeutic agents and treatment strategies...
- Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomasJohn T Mullen
Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Cancer 118:3758-65. 2012..We report the long-term follow-up data on 48 patients treated with this regimen compared to an historical matched-control patient population...
- Outcomes after surgical resection of cardiac sarcoma in the multimodality treatment eraFaisal G Bakaeen
Department of Cardiothoracic Surgery, Baylor College of Medicine, Houston, Tex 77030, USA
J Thorac Cardiovasc Surg 137:1454-60. 2009..Primary cardiac sarcomas are rare tumors carrying poor prognosis. Resection remains the primary therapy. Especially in recent years, chemotherapy and radiation have been used adjunctively...
- Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapyR Garcia-Carbonero
Center for Sarcoma and Bone Oncology, Dana Farber Cancer Institute, Harvard Medical School, Shields Warren Bldg, Room G530, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 22:1480-90. 2004....
- Preclinical xenograft models of human sarcoma show nonrandom loss of aberrationsStine H Kresse
Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Cancer 118:558-70. 2012..Human tumors transplanted into immunodeficient mice (xenografts) are good preclinical models, and it is important to identify possible systematic changes during establishment and passaging in mice...
- Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology GroupJoseph G Pressey
Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Pediatr Blood Cancer 57:930-8. 2011..A previous report utilizing in situ hybridization has provided initial evidence for the expression of Hh targets GLI1 and PTCH in RMS tumors...
- Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survivalAlessandro Gronchi
Department of Surgery, Istituto Nazionale Tumori, Milan, Italy
Ann Surg 251:506-11. 2010..To improve understanding of what is adequate in local treatment of extremity soft tissue sarcomas (ESTS), to maximize the ratio between local control, limb preservation and prognosis...
- Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomasAlexander Stojadinovic
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Ann Surg 235:424-34. 2002To define the significance of positive microscopic resection margins in a large cohort treated for soft tissue sarcoma.
- Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell linesHiromasa Fujii
Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634 8521, Japan
Int J Oncol 34:1381-6. 2009..The aim of the current study was to demonstrate whether the human sarcoma cell lines, osteosarcoma MG63, Ewing's sarcoma HTB166, fibrosarcoma HT1080, possess the stem-like properties ..
- Diagnosis and management of primary breast sarcomaSammy Al-Benna
Operative Reference Centre for Soft Tissue Sarcoma, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Nordrhein Westfalen, Germany
Breast Cancer Res Treat 122:619-26. 2010Primary sarcoma of the breast is an extremely rare and heterogeneous disease. The rarity of this tumour limits most studies to small retrospective case reviews and case reports and has made clinicopathological study difficult...
- Immune selection and emergence of aggressive tumor variants as negative consequences of Fas-mediated cytotoxicity and altered IFN-gamma-regulated gene expressionKebin Liu
Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1402, USA
Cancer Res 65:4376-88. 2005..Thus, in this model, Fas-mediated cytotoxicity, in concert with IFN-gamma-regulated gene expression, mechanistically constituted significant determinants of immune selection of ATV in vivo...
- Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex geneticsGaëlle Pérot
Institut Curie, Genetics and Biology of Cancers, Paris, France
Am J Pathol 177:2080-90. 2010..we could not detect p14 protein suggests that other p14 functions, independent of p53, could be implicated in sarcoma oncogenesis...
- Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas?Rebecca A Gladdy
Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Howard 1209, New York, NY 10065, USA
J Clin Oncol 28:2064-9. 2010..DSS in patients with primary RAS is significantly worse compared with sporadic STS independent of sarcoma histologic type.
- Histology-driven chemotherapy in soft tissue sarcomasMichelle Scurr
Sarcoma Unit, Royal Marsden Hospital, London, UK
Curr Treat Options Oncol 12:32-45. 2011..and ifosfamide are the two chemotherapy drugs that have consistently demonstrated activity in "soft tissue sarcoma" (STS)...
- Combined vascular endothelial growth factor receptor/epidermal growth factor receptor blockade with chemotherapy for treatment of local, uterine, and metastatic soft tissue sarcomaWenhong Ren
Department of Surgical Oncology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 14:5466-75. 2008Soft tissue sarcoma (STS) is a rare heterogeneous malignancy. Overall survival has been stagnant for decades, primarily because systemic therapies are ineffective versus metastases, the leading cause of STS lethality...
- Trends in survival for patients with metastatic soft-tissue sarcomaAntoine Italiano
Department of Medical Oncology, Bergonie Institute, Bordeaux, France
Cancer 117:1049-54. 2011The objective of this study was to determine whether the overall survival of patients with metastatic soft tissue sarcoma (STS) has improved over the last 20 years.
- Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer modelsRachel M Squillace
ARIAD Pharmaceuticals, Inc, 26 Landsdowne Street, Cambridge, MA 02139, USA
Mol Cancer Ther 10:1959-68. 2011..rapamycin analogue that potently inhibits mTOR and has shown significant activity in patients with metastatic sarcoma and endometrial cancer, two diseases where high unmet need remains...
- Time dependence of prognostic factors for patients with soft tissue sarcoma: a Scandinavian Sarcoma Group Study of 338 malignant fibrous histiocytomasJacob Engellau
Department of Oncology, The Jubileum Institute, Lund University, Lund, Sweden
Cancer 100:2233-9. 2004Prognostic factors for metastasis in soft tissue sarcoma govern decisions regarding adjuvant treatment. However, the significance of initial tumor-related prognostic factors over time is largely unknown.
- The outcomes and prognostic factors of patients with soft-tissue sarcomaP Kiatisevi
Institute of Orthopaedic, Lerdsin General Hospital
J Med Assoc Thai 89:334-42. 2006..Occurrence of distant metastasis is associated with older age (> or = 60 years) and decreases disease-specific survival of the patients...
- Molecular classification of soft tissue sarcomas and its clinical applicationsShilpa Jain
Department of Pathology, New York University School of Medicine, New York, NY, USA
Int J Clin Exp Pathol 3:416-28. 2010..Molecular genetics analyses have not only assisted in understanding the molecular mechanism in sarcoma pathogenesis but also demonstrated new relationships within different types of sarcomas leading to a more proper ..
- The clinical relevance of molecular genetics in soft tissue sarcomasJosé Luis Ordóñez
Centro de Investigación del Cáncer IBMCC, Universidad de Salamanca CSIC, Spain
Adv Anat Pathol 17:162-81. 2010..showing relatively simple karyotypes and translocations, which originate gene fusions (eg, EWS-FLI1 in Ewing sarcoma) or point mutations (eg, c-kit in the gastrointestinal tumors) and (b) sarcomas showing unspecific gene ..
- Prognostic factors for disease-specific survival after first relapse of soft-tissue sarcoma: analysis of 402 patients with disease relapse after initial conservative surgery and radiotherapyGunar K Zagars
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 57:739-47. 2003To document the prognostic factors for survival of patients with soft-tissue sarcoma sustaining a first relapse after definitive treatment.
- Co-detection of members of the urokinase plasminogen activator system in tumour tissue and serum correlates with a poor prognosis for soft-tissue sarcoma patientsH Taubert
Department of Oral and Maxillofacial Plastic Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
Br J Cancer 102:731-7. 2010..However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level in both tumour tissue and serum have not been investigated yet.
- Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1Arvind Ravi
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cancer Cell 21:848-55. 2012..Furthermore, Dicer1 null cells from a sarcoma cell line, though depleted of miRNAs, are competent for tumor formation...
- ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESISEnrique A Mesri; Fiscal Year: 2013DESCRIPTION (provided by applicant): Kaposi's sarcoma (KS), caused by the Kaposi's sarcoma-associated herpes virus (KSHV), is a major cancer associated with AIDS and a global health challenge...
- N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus InfectiAquilur Rahman; Fiscal Year: 2010..compound have shown the following promising characteristics: 1) It inhibits HSV-1, HSV-2, HSV-8 (Kaposi's Sarcoma Virus), as well as Vaccinia and Cowpox viruses 2) It is cytotoxic only in virus-infected cells 3) It is active ..
- N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus InfectiAquilur Rahman; Fiscal Year: 2013..manifested as oral HSV-1 and HSV-2 infections, genital HSV-2 infection and HSV-8 infection in Kaposi's sarcoma, which are prevalent in sexually transmitted diseases and immunosuppressed patients...
- Regulation of EBV Latency by EBNA1Paul M Lieberman; Fiscal Year: 2013..protein, our studies will provide novel insight into the genome maintenance mechanisms shared by Kaposi's Sarcoma-Associated Herpesvirus (KSHV) LANA and human papillomavirus (HPV) E2 family members, as well as by cellular ..
- Regulation of KSHV LatencyPaul M Lieberman; Fiscal Year: 2013DESCRIPTION (provided by applicant): KSHV is the causative agent of Kaposi's sarcoma (KS) that occurs most frequently and severely in HIV-AIDS...
- ALS therapies and genomics for mutant TDP-43 and TLS/FUSDon W Cleveland; Fiscal Year: 2010..that mutations in two strikingly similar DNA/RNA binding proteins, TAR DNA-binding protein (TDP-43) and Fused in sarcoma (FUS/TLS), are also primary causes of ALS...
- Herpesvirus protein kinases: Substrate recognition and pathway targeting.S Diane Hayward; Fiscal Year: 2013..Epstein Barr Virus (EBV) and Kaposi's sarcoma associated herpesvirus (KSHV) are associated with AIDS related cancers and human cytomegalovirus (HCMV) with ..
- INTERNATIONAL HERPESVIRUS WORKSHOPJay A Nelson; Fiscal Year: 2012..The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons and in other groups...
- Development of quantitative multiplex RNA in situ hybridizationThomas Tuschl; Fiscal Year: 2013..As a proof of principle, we will apply the approach to improve sarcoma diagnosis through more accurate classification of small blue round cell tumors (SBRCTs) and spindle cell tumors (..
- Role of FUS in ALSHaining Zhu; Fiscal Year: 2013..their mutation can lead to familial ALS, including two genes encoding RNA processing proteins TDP-43 and fused in sarcoma/translocated in liposarcoma (FUS/TLS). FUS is a ubiquitously expressed multi-domain RNA-binding protein...
- INTERNATIONAL HERPESVIRUS WORKSHOPJay A Nelson; Fiscal Year: 2011..The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosupressed persons and in other groups...
- The role of cMET in satellite cells during muscle regenerationMICAH TAUBE WEBSTER; Fiscal Year: 2013DESCRIPTION (provided by applicant): Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma that occurs in children...
- Targeting Kinases that Phosphorylate the KSHV LANA Chromatin Binding DomainS Diane Hayward; Fiscal Year: 2013DESCRIPTION (provided by applicant): KSHV is associated with the endothelial malignancy Kaposi sarcoma (KS) and the B cell cancers primary effusion lymphoma (PEL) and multicentric Castleman disease...
- Novel Compounds to Inactivate Oncogenic Fusion ProteinsJeffrey A Toretsky; Fiscal Year: 2013..The Ewing's Sarcoma Family of Tumors (ESFT) contains a characteristic translocation, t(11:22), which leads to the oncogenic, fusion-..
- Epigenetic regulation of viral infection and replication by periodontal bacteriaFengchun Ye; Fiscal Year: 2013..frequent infections by herpesviruses such as herpes simplex virus (HSV), Epstein Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (KSHV). The oral cavity is also a potential reservoir for latent HIV infection...
- STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXESEdward H Egelman; Fiscal Year: 2012..HSV-1) ICP8, but will then be extended to related viral proteins, such as from Epstein Barr Virus and Kaposi Sarcoma Herpes Virus. III) Structural studies of F-pili, needed for bacterial conjugation, and filamentous bacteriophage...
- LANA and Cellular Gene ExpressionROLF F RENNE; Fiscal Year: 2013DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpesvirus (KSHV), also called Human herpesvirus type 8, is associated with Kaposi's sarcoma (KS) and two lymphoproliferative diseases: primary effusion ..
- INTERNATIONAL HERPESVIRUS WORKSHOPJay A Nelson; Fiscal Year: 2013..The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons and in other groups...
- Assay Development for Inhibitors of KSHVPaul M Lieberman; Fiscal Year: 2010..is to develop a robust high-throughput screen for identification of small molecule inhibitors of Kaposi's Sarcoma Associated Herpes virus (KSHV) and associated diseases...
- Modulation of histone deacetylase activity by a gammaherpesviral kinaseBryan C Mounce; Fiscal Year: 2013..The human gammaherpesviruses Epstein-Barr Virus (EBV) and Kaposi's Sarcoma Associated Herpesvirus (KSHV) are associated with diverse diseases, including several cancers...
- Development of a novel vaccine for protection against gammaherpesvirus infectionBlossom A Damania; Fiscal Year: 2010..Infection with HIV causes a depletion of CD4+ T cells, which leads to immune suppression. Kaposi's sarcoma (KS), induced by KSHV, is the most common neoplasm seen among HIV infected individuals...
- Generation and Evaluation of KSHV VLPs as VaccinesGARY S contact HAYWARD; Fiscal Year: 2010..Kaposi's sarcoma (KS) was one of the original defining opportunistic infections in the AIDS epidemic, when these highly angiogenic ..
- INTERNATIONAL HERPESVIRUS WORKSHOPJay A Nelson; Fiscal Year: 2010..The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosupressed persons and in other groups...
- Beta-catenin is a molecular target of the Fanconi anemia core complexKim Hien T Dao; Fiscal Year: 2013..research experience began with her PhD training in the area of cancer biology and RAS signaling in human fibro sarcoma cell lines...
- Lysophosphatidic Acid in OncogenesisXianjun Fang; Fiscal Year: 2010..The tumors include malignant lymphoma, lung adenocarcinoma, high-grade sarcoma, leiomyosarcoma, plasmacytoma and pilomatrixoma...
- Walleye Dermal Sarcooma Virus Accessory Protein FunctionSandra L Quackenbush; Fiscal Year: 2012..Walleye dermal sarcomas (WDS) are etiologically associated with the complex retrovirus, walleye dermal sarcoma virus (WDSV)...
- KSHV Lytic DNA Replication and its Control MechanismSubhash C Verma; Fiscal Year: 2013..gap in the understanding of molecular mechanism involved in regulating lytic DNA replication of Kaposi's sarcoma associated herpesvirus (KSHV) also known as Human Herpesvirus 8 (HHV8)...
- Impact of Vaccination against GM2, GD2 and GD3 on Disease Free Survival in ResectWolfgang W Scholz; Fiscal Year: 2012..by applicant): This SBIR grant application for the clinical development of a novel vaccine to treat patients with sarcoma is based on a foundation of 30 years of studies at Memorial Sloan Kettering Cancer Center (MSKCC)...
- Conference Support for International Congress on Oncogenic HerpesvirusesPaul M Lieberman; Fiscal Year: 2012..and innovative in that it will serve as the first combined meeting of the International Workshop on Kaposi's Sarcoma-Associated Herpesvirus (KSHV) and Related Agents (15th Annual Meeting) and the International Symposium on Epstein-..
- Rapamycin-induced Selective Apoptosis in Malignant CellsPeter J Houghton; Fiscal Year: 2012..This approach appears to be highly effective against IGF-1-driven osteosarcoma and Ewing sarcoma xenograft models in vivo when rapamycin is combined with an antibody that blocks IGF-1 binding to the receptor...
- MOUSE MODELS FOR UNDERSTANDING HOST RESPONES TO INTRACELLULAR PATHOGENSEllen A Robey; Fiscal Year: 2010..Murine &Human cytomegalovirus, Murine herpes virus 68, Moloney Murine Leukemia Virus, Kaposi's Sarcoma Herpes Virus, Mouse Hepatitis Virus, Mouse Adeno Virus, Polyomavirus)...
- Ewing's Sarcoma Resistance to Immunity and RadiationJoyce C Solheim; Fiscal Year: 2013DESCRIPTION (provided by applicant): Ewing's sarcoma is a very painful cancer of the bone (and, more rarely, soft tissue) that strikes children and adolescents...
- ASSEMBLY OF THE HERPES SIMPLEX VIRUS CAPSIDJay C Brown; Fiscal Year: 2012..effective against other herpesviruses including human cytomegalovirus, Epstein- Barr virus and Kaposi's sarcoma-associated herpesvirus...
- Cardiac Sparing Whole Lung IMRT in Children and Young Adults with Lung MetastasesJOHN ANDREW KALAPURAKAL; Fiscal Year: 2012..technique) is considered the standard of care for most patients with lung metastases from Wilms tumor, Ewing Sarcoma and rhabdomyosarcoma. Several studies have shown increased cardiac complications after WLI and chemotherapy...
- KSHV genome modification in KS tissueErle S Robertson; Fiscal Year: 2013..In the HIV positive immunocompromised patients, pleural effusion lymphoma (PELs), Kaposi's sarcoma (KS) and Multicentric Castleman's Disease (MCD) are common...
- Engineered imaging nanoparticles for real-time detection of cancer in the tumor bW David Lee; Fiscal Year: 2013..These imaging agents are based upon the design of our lead candidate for sarcoma and breast cancer indications, LUM015, which has been approved by the FDA to start first-in-human clinical trials ..
- ZNF-Mediated Resistance to Imatinib Mesylate in Gastrointestinal Stromal TumorLori Rink; Fiscal Year: 2013..I will be mentored by Drs. Margaret von Mehren (Professor &Director, Sarcoma Program), Andrew K...
- In vivo model of hypoxia in Ewing SarcomaJoanna B Kitlinska; Fiscal Year: 2013DESCRIPTION (provided by applicant): Ewing's sarcoma family of tumors (ESFT) is a group of highly aggressive malignancies, the treatment of which remains an unsolved clinical problem...
- Human Herpesvirus-8 Replication and Kaposi Sarcoma Response to TreatmentWarren Phipps; Fiscal Year: 2013..training program which will allow him to develop a career as an independent investigator in the field of Kaposi sarcoma (KS) and HIV-associated malignancies...
- Targeting EWS/FLI1-driven pathways to improve therapeutic gains in Ewing's SarcomVicente Notario; Fiscal Year: 2012DESCRIPTION (provided by applicant): Tumors of the Ewing's sarcoma family (ESFT) are solid, highly malignant neoplasms of the bone and soft tissues that most often affect children and adolescents, being the second most common bone ..
- Exploring Sarcoma Metastatic PotentialKURT RICHARD WEISS; Fiscal Year: 2013..He has worked with sarcoma research experts at the MD Anderson Cancer Center and the National Cancer Institute as well as the Universities ..
- K-Rta as a Novel SUMO and Epigenetic RegulatorYoshihiro Izumiya; Fiscal Year: 2013..mechanisms, involving post-translation modification of chromatin proteins, in the life cycle of Kaposi's sarcoma herpesvirus (KSHV), which is an etiological agent of Kaposi's sarcoma (KS), an AIDS-associated malignancy...
- Pathogenic mechanisms of alveolar rhabdomyosarcomaMARGARET MARY CHOU; Fiscal Year: 2013..Rhabdomyosarcoma is the most common pediatric soft tissue sarcoma;of the various subtypes, ARMS carries the worst prognosis...
- Roles for TDP-43 and FUS in ALS Using Motor Neurons from Embryonic Stem CellsDara Ditsworth; Fiscal Year: 2012..Mutations in two DNA/RNA binding proteins, TAR DNA-binding protein (TDP-43) and Fused in Sarcoma (FUS) have recently been identified as primary causes of inherited ALS and have led to what is likely to be a ..
- Nuclear Export of Retroviral RNPs: Cytoplasmic fates determined in the nucleusREBECCA J KADDIS; Fiscal Year: 2013DESCRIPTION (provided by applicant): Rous sarcoma virus (RSV), the first tumor virus identified, has been the genesis for seminal discoveries in cancer biology and retrovirology, including oncogenes, reverse transcription, and ..
- Mechanisms of Tyrosine Kinase Inhibitor Resistance in GI Stromal TumorsMichael Heinrich; Fiscal Year: 2012..provided by applicant): Gastrointestinal stromal tumors (GISTs), the most common type of adult soft tissue sarcoma, are diagnosed in approximately 5,000-10,000 Americans each year...
- Molecular library screen for suppressors of FUS proteinopathyFrank P Shewmaker; Fiscal Year: 2013..Recently, the DNA/RNA-binding proteins FUS (Fused in Sarcoma) and TDP-43 (TAR DNA-binding protein) were implicated in these diseases...
- Transcriptional control mechanisms by ETS factorsBarbara J Graves; Fiscal Year: 2013..These regulatory proteins play central roles in a variety of human cancers, including prostate cancer, Ewings sarcoma and various leukemias...
- Cellular Protein Involved in Trafficking of HIV-1Carol A Carter; Fiscal Year: 2013..Gag proteins with domains derived from HIV- 1 Gag, whose budding is dependent on the calcium machinery and avian sarcoma virus Gag, whose release is not, will be used to identify the key determinants...
- MANIPULATION OF KINASE ACTIVITY BY KSHV LANAS Diane Hayward; Fiscal Year: 2010DESCRIPTION (provided by applicant): Kaposi's sarcoma associated herpesvirus (KSHV) is associated with the endothelial lesion Kaposi's sarcoma and the B cell malignancies primary effusion lymphoma and multicentric Castleman&..
- Understanding the mechanism of KSHV latent DNA replicationSubhash C Verma; Fiscal Year: 2011..Kaposi's sarcoma associated Herpesvirus (KSHV) predominantly infects B cells and endothelial cells and persists indefinitely with ..
- Phase I Study of IMC-A12 in Combination with TemsirolimusAung Naing; Fiscal Year: 2010..The drug combination tested in this protocol has the promise of providing broad applicability for tumor types such as breast, sarcoma and pancreas in subsequent phase II trials.
- KSHV-Ori-Lyt-Dependent DNA ReplicationYan Yuan; Fiscal Year: 2012DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8 (HHV-8), is a human pathogen responsible for several AIDS associated malignancies including Kaposi's ..
- Developing in vivo and in vitro Models for ALS Caused by Mutant FUSXugang Xia; Fiscal Year: 2011..A recent advance in ALS research is the discovery of pathogenic mutations in the Fused in Sarcoma (FUS) gene in ALS. FUS is a highly conserved ribonucleoprotein encoded by the FUS gene of 15 exons...
- Transport and Insertion of Outer Membrane ProteinsSangita Sinha; Fiscal Year: 2009..virus which causes infectious mononucleosis and malignant tumors of lymphoid and epithelial tissues and Kaposi Sarcoma virus, which causes Kaposi sarcoma tumors, especially among immunocompromised individuals such as AIDS patients ..
- Dissecting sarcoma complexity via innovative microRNA and informatics approachesDimitrios Spentzos; Fiscal Year: 2012..in cancer genomics, and recently assumed an independent translational appointment with a clinical focus in sarcoma. Sarcoma is a disease with a substantial clinical and biologic complexity and high incidence in younger ..
- Anti-viral IL6 approach to mitigate KSHV-related diseaseScott W Wong; Fiscal Year: 2012..RRV, like Kaposi's sarcoma-associated herpesvirus (KSHV), encodes an interleukin-6 (IL-6) homologue, which is thought to be a necessary ..
- The role of cell surface heat shock protein 90 in KSHV pathogenesisMICHAEL ROBERT DEFEE; Fiscal Year: 2013DESCRIPTION (provided by applicant): Kaposi sarcoma (KS) is the most common cancer arising in HIV- infected individuals with as many as 60% of cases involving the oral cavity...
- Rhesus HHV-8 homologue in AIDS-related malignanciesScott W Wong; Fiscal Year: 2013..recently identified to be associated with cancer in humans in 1995 is human herpesvirus 8 (HHV8)/Kaposi's sarcoma-associated herpesvirus (KSHV)...
- Genome Persistence of KSHVErle S Robertson; Fiscal Year: 2013DESCRIPTION (provided by applicant): Kaposi's sarcoma associated herpes virus (KSHV/HHV-8) is the second identified gammaherpesvirus associated with at least 3 major proliferative diseases...
- DNA sensors and associated signaling pathways in the innate immune responseKatherine A Fitzgerald; Fiscal Year: 2013..evidence also indicates that IFI16 can form an inflammasome in responses to nuclear sensing of Kaposi's Sarcoma Herpes Virus infection...
- An Animal Model for Kaposi's SarcomaChristopher Parsons; Fiscal Year: 2009DESCRIPTION (provided by applicant): Kaposi's sarcoma (KS) is a multicellular, angiogenic tumor arising in the setting of immunosuppression, including AIDS and solid organ transplantation...
- VEGFs in Artery-Vein Imbalance in AIDS-Kaposi SarcomaParkash Gill; Fiscal Year: 2009Kaposi's sarcoma (KS) develops as a vascular proliferate process in response to infection of endothelial cells or their precursors with HHV-8...
- Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in AfricaJeffrey Martin; Fiscal Year: 2009..In sub-Saharan Africa, the intersection between the HIV epidemic and the endemic nature of Kaposi's sarcoma-associated herpesvirus (KSHV) infection has caused Kaposi's sarcoma (KS) to become the most common ..
- Randomized Phase II Study of QS-DG +/- Trivalent Ganglioside Vaccine in Stage IV Richard Carvajal; Fiscal Year: 2009Despite potentially curative therapies, the majority of patients with treated metastatic sarcoma die as a result of subsequent disease relapse...
- PF-8 AND POL-8 OF KSHV AS TARGETS OF VIRAL DNA SYNTHESISRobert Ricciardi; Fiscal Year: 2001DESCRIPTION: (Adapted from Applicant's Abstract) Kaposi's sarcoma-associated herpesvirus (KSHV) is the apparent etiological cause of Kaposi's sarcoma, a neoplasm of frequent occurrence in HIV infected individuals...
- Engineered imaging nanoparticle for realtime detection of cancer in the tumor bedW David Lee; Fiscal Year: 2011..agent and detection system for labeling and real- time detection of residual cancer in the tumor bed during sarcoma resection surgery that will be quickly adopted by surgeons/hospitals because it can eliminate or significantly ..
- KSHV TRANSFORMATION AND ANGIOGENESIS IN KAPOSIS SARCOMAEthel Cesarman; Fiscal Year: 2001Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV 8), is invariably present in Kaposi's sarcoma (KS) lesions where it has been localized in the endothelial cells as well as in the spindle cells, which are ..
- YK-4-279 specifically targets ETS family fusion-protein cancers in clinical trialJeffrey A Toretsky; Fiscal Year: 2010..over the past eight years supporting direct targeting of an ideal cancer target in the very rare Ewing's Sarcoma. This ideal cancer target originates from a tumor-specific chromosomal translocation only present in the tumor ..
- KAPOSIS SARCOMA ASSOCIATED VIRUS IN AIDS/LYMPHOMASEthel Cesarman; Fiscal Year: 1999The principal objective of the studies proposed here is to determine the role of the recently identified Kaposi's sarcoma-associated herpesvirus (KSHV) in the pathogenesis of AIDS-associated body cavity based lymphomas (AIDS-BCBLs)...
- BIOLOGICAL STUDIES IN KAPOSI'S SARCOMAPHILIP BROWNING; Fiscal Year: 2000..abstract) Since early in the AIDS epidemic, HIV-infected individuals have higher incidence rates of Kaposi's sarcoma (ICS) than HIV-1 infected age-matched controls...
- CHEMO/IMMUNOTHERAPY FOR HIGH RISK EWINGS SARCOMAEugenie Kleinerman; Fiscal Year: 2001DESCRIPTION: (adapted verbatim from the investigator's abstract) Patients with Ewing's sarcoma family of tumors who are at high-risk for relapse are those with metastic disease at diagnosis, with a primary tumor of the humerus, femur or ..