neurocytoma

Summary

Summary: A benign brain tumor composed of neural elements which most often arise from the SEPTUM PELLUCIDUM and the walls of the lateral ventricles. Immunohistochemistry and electron microscopy evaluations may reveal expression of neuron specific enolase and synaptophysin and cells containing microtubuli, neurosecretory granules, and presynaptic vesicles. (From Acta Med Port 1994 Feb;7(2):113-9)

Top Publications

  1. ncbi Extraventricular neurocytoma: morphological and immunohistochemical considerations on differential diagnosis
    Anna Maria Buccoliero
    Dipartimento di Patologia Umana e Oncologia, Universita degli Studi di Firenze, Italy
    Pathol Res Pract 198:627-33; discussion 635-8. 2002
  2. ncbi Pathologic quiz case. Intraventricular mass in a 31-year-old man
    George M Corcoran
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Arch Pathol Lab Med 126:497-8. 2002
  3. ncbi Fourth ventricle neurocytoma with lipomatous and ependymal differentiation
    Anne Jouvet
    Hopital Neurologique, BP Lyon Montchat, 69394, Lyon Cedex 03, France
    Acta Neuropathol 109:346-51. 2005
  4. ncbi Central neurocytoma in the vermis of the cerebellum
    Neelkamal Kapoor
    Department of Pathology, Gandhi Medical College, Bhopal 462 001, India
    Indian J Pathol Microbiol 52:108-9. 2009
  5. pmc Primary culture of central neurocytoma: a case report
    Sun Ha Paek
    Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University, Seoul, Korea
    J Korean Med Sci 25:798-803. 2010
  6. ncbi Central neurocytoma: an immunohistochemical, ultrastructural and cell culture study
    S Ishiuchi
    Department of Pathology, Gunma University School of Medicine, Japan
    Acta Neuropathol 94:425-35. 1997
  7. ncbi Central neurocytoma presenting with intratumoral hemorrhage
    J Jamshidi
    Department of Neurosurgery, Yukokai General Hospital, Ibaraki, Osaka, Japan
    Neurosurg Rev 24:48-52. 2001
  8. ncbi A neurocytoma and an associated lenticulostriate artery aneurysm presenting with intraventricular hemorrhage: case report
    G E Vates
    Department of Neurological Surgery, University at San Francisco, University of California, 94143, USA
    Neurosurgery 49:721-5. 2001
  9. ncbi Treatment options for central neurocytoma
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neurology 59:1268-70. 2002
  10. ncbi Treatment of atypical neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 100:814-7. 2004

Research Grants

Detail Information

Publications187 found, 100 shown here

  1. ncbi Extraventricular neurocytoma: morphological and immunohistochemical considerations on differential diagnosis
    Anna Maria Buccoliero
    Dipartimento di Patologia Umana e Oncologia, Universita degli Studi di Firenze, Italy
    Pathol Res Pract 198:627-33; discussion 635-8. 2002
    b>Neurocytoma is an unusual neuronal tumor especially affecting young people. It commonly arises in the ventricles and has a benign outcome...
  2. ncbi Pathologic quiz case. Intraventricular mass in a 31-year-old man
    George M Corcoran
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Arch Pathol Lab Med 126:497-8. 2002
  3. ncbi Fourth ventricle neurocytoma with lipomatous and ependymal differentiation
    Anne Jouvet
    Hopital Neurologique, BP Lyon Montchat, 69394, Lyon Cedex 03, France
    Acta Neuropathol 109:346-51. 2005
    ..The immunophenotype of our case, with glial, ependymal, and neuronal or neuroendocrine markers, suggest a neurocytoma with lipomatous and ependymal differentiation. This tumor resembled those derived from circumventricular organs...
  4. ncbi Central neurocytoma in the vermis of the cerebellum
    Neelkamal Kapoor
    Department of Pathology, Gandhi Medical College, Bhopal 462 001, India
    Indian J Pathol Microbiol 52:108-9. 2009
    ..A case of central neurocytoma of the vermis of the cerebellum is being reported in this article...
  5. pmc Primary culture of central neurocytoma: a case report
    Sun Ha Paek
    Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University, Seoul, Korea
    J Korean Med Sci 25:798-803. 2010
    ..The tumour was removed and confirmed as a central neurocytoma (CN)...
  6. ncbi Central neurocytoma: an immunohistochemical, ultrastructural and cell culture study
    S Ishiuchi
    Department of Pathology, Gunma University School of Medicine, Japan
    Acta Neuropathol 94:425-35. 1997
    To clarify the histogenesis and differentiation potential of central neurocytoma, a pathological investigation of seven tumors from three patients was conducted using immunohistochemistry and ultrastructural analysis in addition to ..
  7. ncbi Central neurocytoma presenting with intratumoral hemorrhage
    J Jamshidi
    Department of Neurosurgery, Yukokai General Hospital, Ibaraki, Osaka, Japan
    Neurosurg Rev 24:48-52. 2001
    ..Sudden hemorrhages within the tumor were considered to cause the acute onset of symptoms. Although central neurocytoma is not commonly known as a tumor-producing intracranial hemorrhage or to cause abrupt clinical deterioration, ..
  8. ncbi A neurocytoma and an associated lenticulostriate artery aneurysm presenting with intraventricular hemorrhage: case report
    G E Vates
    Department of Neurological Surgery, University at San Francisco, University of California, 94143, USA
    Neurosurgery 49:721-5. 2001
    OBJECTIVE AND IMPORTANCE: Hemorrhage associated with central neurocytoma has been described previously, but never in association with an aneurysm originating from a feeding artery...
  9. ncbi Treatment options for central neurocytoma
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neurology 59:1268-70. 2002
    ..authors, this retrospective analysis compares four different therapeutic approaches in the treatment of central neurocytoma: complete resection (n = 108), complete resection plus radiotherapy (n = 30), incomplete resection (n = 74), ..
  10. ncbi Treatment of atypical neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 100:814-7. 2004
    ..The objective of this analysis was to define the optimal treatment for patients with these atypical tumors...
  11. ncbi Pigmented central neurocytoma
    Tim Rasmus Kiehl
    Department of Pathology, WRN2, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Acta Neuropathol 107:571-4. 2004
    Central neurocytoma is a low-grade neuronal neoplasm that occurs most often within the lateral ventricles. We report the case of a 60-year-old woman who presented with gait problems, headache and memory loss...
  12. ncbi Central neurocytoma: a review
    Meic H Schmidt
    Department of Neurological Surgery, University of Utah, Salt Lake City, UT 84132, USA
    J Neurooncol 66:377-84. 2004
    ..Overall, this paper reviews the findings of the larger studies and highlights some of the important case reports that contribute to the current management of central neurocytomas...
  13. ncbi Cytodiagnosis of central neurocytoma in intraoperative preparations
    Yasuo Sugita
    Department of Pathology, Saga Medical School, Nabeshima 5 1 1, Saga 849 8501, Japan
    Acta Cytol 48:194-8. 2004
    ..To assess the cytologic features in smear preparations of 3 central neurocytomas...
  14. ncbi Atypical extraventricular neurocytoma with oligodendroglioma-like spread and an unusual pattern of chromosome 1p and 19q loss
    Robert E Mrak
    Department of Pathology, University of Arkansas for Medical Sciences, Littlle Rock, AR 72205, USA
    Hum Pathol 35:1156-9. 2004
    ..This tumor, best classified as an atypical neurocytoma with oligodendroglia-like spread, supports suggestions of a close histogenic relationship between ..
  15. ncbi Fourth ventricular neurocytoma: case report and review of the literature
    Douglas J Cook
    University of Toronto, Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada
    Can J Neurol Sci 31:558-64. 2004
    Central neurocytoma is a tumour that typically occurs in young adults in close association with the lateral and third ventricles of the cerebrum.
  16. pmc Well-differentiated neurocytoma: what is the best available treatment?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neuro Oncol 7:77-83. 2005
    ..Furthermore, all published well-differentiated neurocytoma cases were reviewed for surgery, radiotherapy, and prognosis...
  17. ncbi Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma
    Heon You
    Neuro Oncology Clinic, Center for Specific Organ Center, National Cancer, Seoul, Korea
    J Neurooncol 74:1-8. 2005
    ..But CNs might be originated from rather neuronally committed stem cells and SEs from rather glially committed stem cells...
  18. ncbi Challenging diagnosis: oligodendroglioma versus extraventricular neurocytoma
    M Mut
    Department of Neurosurgery, Hacettepe University Institute of Neurological and Psychiatric Sciences, Hacettepe University, Sihhiye Ankara, Turkey
    Clin Neuropathol 24:225-9. 2005
    ..was whether the recurrent tumor was an oligodendroglioma with neuronal differentiation or an extraventricular neurocytoma initially misdiagnosed as oligodendroglioma...
  19. ncbi Neurocytoma manifesting as intraventricular hemorrhage--case report
    Hiroki Nishibayashi
    Department of Neurological Surgery, Wakayama Medical University, Japan
    Neurol Med Chir (Tokyo) 46:41-5. 2006
    A 43-year-old man presented with a neurocytoma manifesting as severe headache and disturbance of consciousness...
  20. ncbi Treatment recommendations for the various subgroups of neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurooncol 77:305-9. 2006
    ..The data of all neurocytoma patients reported since 1982, when this entity were reviewed for age, gender, extent of resection, MIB-1 ..
  21. ncbi Central neurocytoma: a novel appraisal of a polymorphic pathology. Our experience and a review of the literature
    Jacopo Lenzi
    Department of Neurosurgery, University of Rome La Sapienza, Rome, Italy
    Neurosurg Rev 29:286-92; discussion 292. 2006
    Central neurocytoma should be considered in the differential diagnosis of intraventricular tumours...
  22. ncbi Neurocytoma: a comprehensive review
    Mehar Chand Sharma
    Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Neurosurg Rev 29:270-85; discussion 285. 2006
    ..role of adjuvant radiotherapy apparently seems to benefit patients with incomplete resection and in atypical neurocytoma. Utility of other therapeutic regimen, however, remains shrouded in controversy...
  23. ncbi Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor
    Addisalem T Makuria
    Department of Pathology, Georgetown University Hospital, 3900 Reservoir Road, N W, Washington, DC 20007, USA
    J Neurooncol 82:199-205. 2007
    Differentiating oligodendroglioma from extraventricular neurocytoma by conventional light microscopy alone can present a diagnostic challenge...
  24. ncbi Neurocytoma is a tumor of adult neuronal progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 26:12544-55. 2006
    Central neurocytoma (CN) is a rare periventricular tumor, whose derivation, lineage potential, and molecular regulation have been mostly unexplored...
  25. ncbi Central neurocytoma: management recommendations based on a 35-year experience
    James L Leenstra
    Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 67:1145-54. 2007
    ..METHODS AND MATErials: The data from 45 patients with central neurocytomas diagnosed between 1971 and 2003 were retrospectively evaluated. Various combinations of surgery, radiotherapy (RT), and chemotherapy had been used for treatment...
  26. ncbi Central neurocytoma: typical magnetic resonance spectroscopy findings and atypical ventricular dissemination
    Ing Berne Yeh
    Department of Diagnostic Imaging, National University Hospital, Singapore 119074, Singapore
    Magn Reson Imaging 26:59-64. 2008
    ..Although it may be difficult to distinguish CNC on conventional neuroimaging, typical MR spectroscopy (MRS) features have been reported. We describe the MRI and MRS features of CNC...
  27. pmc Central neurocytoma: a clinical, radiological and pathological study of nine cases
    Chun Lin Chen
    Department of Neurosurgery, Taichung Veterans General Hospital, 160, Sec 3, Taichung Harbor Road, Taichung 40705, Taiwan, ROC
    Clin Neurol Neurosurg 110:129-36. 2008
    Central neurocytoma is a rare intraventricular brain tumor that affects young adults and presents with increased intracranial pressure secondary to obstructive hydrocephalus...
  28. doi Central neurocytoma responsive to topotecan, ifosfamide, carboplatin
    Elham Amini
    Department of Pediatrics, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Pediatr Blood Cancer 51:137-40. 2008
    A 5-year-old male presented with spinal cord drop metastasis from a recurrent neurocytoma. Topotecan (0...
  29. doi Long-term outcome of conventional radiation therapy for central neurocytoma
    Sun Ha Paek
    Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
    J Neurooncol 90:25-30. 2008
    The authors report the long-term outcome of conventional radiation therapy (RT) in six cases of central neurocytoma (CN)...
  30. pmc Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma
    Fausto J Rodriguez
    Department of Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Brain Pathol 19:623-9. 2009
    ..5 to 5.5 years after first resection. These results suggest that 1p19q loss and t(1;19) occur in a subset of EVN, and may be associated with aggressive histology in these tumors...
  31. doi Immunohistochemical study concerning the origin of neurocytoma--a case report
    Hirohito Yano
    Department of Neurosurgery, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Pathol Oncol Res 15:301-5. 2009
    ..Histological diagnosis was atypical neurocytoma. Immunohistochemical analyses revealed that the tumor was strongly positive for not only neural markers but ..
  32. doi Imaging findings of extraventricular neurocytoma: report of 3 cases and review of the literature
    G F Yang
    Department of Nuclear Medicine, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu, China
    AJNR Am J Neuroradiol 30:581-5. 2009
    Extraventricular neurocytoma (EVN) is rare entity with similar biologic behavior and histopathologic characteristics to neurocytomas that occur in the lateral ventricles, according to the 2007 World Health Organization classification...
  33. doi Neurocytoma of the spinal cord: report of three cases and review of the literature
    Filippo Maria Polli
    Neurosurgery, Department of Neurosciences, Sapienza University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161 Roma, Italy
    Acta Neurochir (Wien) 151:569-74; discussion 574. 2009
    ..Composed of small round cells with neuronal differentiation, neurocytoma has a particularly favourable prognosis...
  34. ncbi Central neurocytoma presenting with massive hemorrhage leading to coma--case report
    Yuzo Terakawa
    Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka
    Neurol Med Chir (Tokyo) 50:139-43. 2010
    A 21-year-old man presented with a hemorrhagic central neurocytoma manifesting as acute onset of disturbance of consciousness and right hemiparesis...
  35. ncbi Cytologic diagnosis of central neurocytoma in intraoperative squash preparations: a report of 2 cases
    Tadao K Kobayashi
    Department of Laboratory Medicine, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc, Ritto, Shiga, Japan
    Acta Cytol 54:209-13. 2010
    Central neurocytoma is a rare central nervous system tumor typically found in the lateral ventricles and at the spectrum pellucidum...
  36. doi Extraventricular neurocytoma with atypical features and ganglionic differentiation
    Shaun Chou
    Department of Tissue Pathology, ICPMR, Westmead Hospital, Westmead, New South Wales, Australia
    J Clin Neurosci 17:920-2. 2010
    Extraventricular neurocytoma (EVN) is an unusual variant of central neurocytoma located outside the ventricular system...
  37. doi A clinicopathological, immunohistochemical and neuroradiological study of eight patients with central neurocytoma
    Sushila Jaiswal
    Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India
    J Clin Neurosci 18:334-9. 2011
    ..1 years) with neurocytoma. Raised intracranial pressure was the most common presenting feature...
  38. ncbi Emotion and cognitive function assessment of patients with central neurocytoma resection through transcortical frontal approach: a 5-year postoperative follow-up study
    Zhi feng Shi
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China
    Chin Med J (Engl) 124:2593-8. 2011
    Central neurocytoma accounts for 0.1% of primary brain tumor that often occurs in young adults. Surgery is the main treatment for central neurocytoma and the rate of 5-year survival reaches up to over 90%...
  39. doi Central neurocytoma: long-term outcomes of multimodal treatments and management strategies based on 30 years' experience in a single institute
    Jin Wook Kim
    Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
    Neurosurgery 72:407-13; discussion 413-4. 2013
    A thorough investigation of the long-term outcomes of central neurocytoma (CN) after different treatments is required to establish optimal management strategies.
  40. ncbi Ultrastructural characterization of central neurocytomas using collagen gel culture
    T Tsuchida
    Department of Neurosurgery, Kansai Medical School, Osaka, Japan
    Ultrastruct Pathol 22:233-8. 1998
    Central neurocytoma is a rare brain tumor with neuronal differentiation. Cultured central neurocytoma cells are poorly described because of the tumor's scarcity...
  41. ncbi Long-term outcome in patients with central neurocytoma following stereotactic biopsy and radiation therapy
    V Kulkarni
    Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India
    Br J Neurosurg 16:126-32. 2002
    ..Long-term outcome was studied in patients with central neurocytoma who were treated with radiation therapy...
  42. ncbi Genetic differences between neurocytoma and dysembryoplastic neuroepithelial tumor and oligodendroglial tumors
    Hironori Fujisawa
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Neurosurg 97:1350-5. 2002
    Because of their histological similarities, it is occasionally difficult to differentiate neurocytoma and dysembryoplastic neuroepithelial tumor (DNT) from oligodendroglial tumors...
  43. ncbi Melanoma metastatic to central neurocytoma: a novel case of tumor-to-tumor metastasis
    Heather M Brown
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Neurooncol 61:209-14. 2003
    ..At autopsy, the second lesion was found to be a central neurocytoma harboring metastatic melanoma...
  44. ncbi The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literature
    Cornelia S von Koch
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Surg Neurol 60:560-5. 2003
    ..However, more aggressive variants have been described requiring additional surgical resection, radiation, or chemotherapy. Chemotherapy has rarely been used as an adjuvant therapy for central neurocytomas...
  45. ncbi Peritoneal dissemination from central neurocytoma: case report
    Mauricio Coelho Neto
    Neurosurgical Department, Instituto de Neurologia de Curitiba, Curitiba, PR, Brazil
    Arq Neuropsiquiatr 61:1030-4. 2003
    Central neurocytoma is a low grade tumor of neuroglial origin and a relatively new histological entity. Only a few cases have been reported and its biological behavior is still uncertain...
  46. ncbi Forskolin promotes astroglial differentiation of human central neurocytoma cells
    Bum Jun Kim
    Department of Anatomy, School of Medicine, Ajou University, Suwon 442 749, Korea
    Exp Mol Med 36:52-6. 2004
    Human central neurocytoma is a kind of the brain tumors that are usually found in anterior part of the lateral ventricles...
  47. ncbi Defining the best available treatment for neurocytomas in children
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 101:2629-32. 2004
    ..Since this entity was introduced in 1982, approximately 60 cases have been reported among patients age </= =18 years of age. The current analysis was performed to define the best available neurocytoma therapy in children.
  48. ncbi Central neurocytomas with MIB-1 labeling index over 10% showing rapid tumor growth and dissemination
    Yoshikazu Ogawa
    Department of Neurosurgery, Iwate Prefectural Central Hospital, Morioka, Japan
    J Neurooncol 79:211-6. 2006
    Central neurocytoma is recognized as a indolent intraventricular tumor arising from the ependyma around the foramen of Monro and anterior part of the lateral ventricles, and well demarcated from the brain parenchyma...
  49. ncbi Pontine atypical neurocytoma: case report
    Bradley M Swinson
    Department of Neurosurgery, University of Florida, Gainesville 32610, USA
    Neurosurgery 58:E990; discussion E990. 2006
    ..Extraventricular neurocytomas are very rare, and this is only the second reported case of a pontine neurocytoma. We discuss the clinical presentation, histology, and treatment of these rare tumors.
  50. ncbi Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma. Case report
    Masayuki Kanamori
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Neurosurg 107:185-9. 2007
    ..astrocytoma and anaplastic oligodendroglioma that developed 6 years after subtotal resection of a central neurocytoma in his right lateral ventricle...
  51. doi Extraventricular neurocytoma of the spinal cord in a dog
    M Huisinga
    Institut für Veterinär Pathologie, Universitat Giessen, Germany
    Vet Pathol 45:63-6. 2008
    Central neurocytoma is a rare, prognostically favorable neuronal tumor of the human central nervous system, typically located intraventricularly near the foramen of Monro...
  52. doi Recently established entities of central nervous system tumors: review of radiological findings
    Shiori Amemiya
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Comput Assist Tomogr 32:279-85. 2008
    ..reports, we describe 4 neuronal and mixed neuronal-glial tumors (papillary glioneuronal tumor, extraventricular neurocytoma, rosette-forming glioneuronal tumor of the fourth ventricle, and glioneuronal tumor with neuropil-like islands),..
  53. doi Intraoperative imprint cytology of central neurocytoma: The great oligodendroglioma mimicker
    Michal Klysik
    Department of Radiology, University of Colorado at Denver, Aurora, Colorado, USA
    Diagn Cytopathol 38:202-7. 2010
    ..Central neurocytoma is a intraventricular neoplasm, typically located in the region of the foramen of Monro, affecting mostly young ..
  54. ncbi Ganglioneurocytoma mimicking a malignant tumor: case report with a literature review of the MRI appearance of neurocytomas and gangliogliomas
    A Chan
    Department of Pediatrics (Neurology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, 40 E. Laurel Rd, Suite 100, Stratford, NJ 08084, USA
    J Neuroimaging 11:47-50. 2001
    ..Contrast enhancement was extensive and heterogeneous, mimicking a malignant tumor. Neuropathology revealed a ganglioneurocytoma...
  55. ncbi Ultrastructural characteristics of central neurocytoma in cell culture
    M C Lee
    Department of Pathology, Chonnam National University Medical School, Kwangju, Korea
    Ultrastruct Pathol 21:393-404. 1997
    The study was performed to determine the ultrastructural characteristics of central neurocytoma and its features in primary cell culture...
  56. ncbi Proton magnetic resonance spectroscopy of neurocytoma outside the ventricular region--case report and review of the literature
    W Moller-Hartmann
    Department of Neuroradiology, University Hospital, University of Technology, Aachen, Germany
    Neuroradiology 44:230-4. 2002
    Central neurocytoma is classically considered as an intraventricular benign tumour, largely based on data from small retrospective series and single case reports...
  57. ncbi An intraventricular brain tumour in a young woman. Part 1. Central neurocytoma
    Hwei Yee Lee
    Department of Pathology, Singapore General Hospital
    Pathology 34:185-8. 2002
  58. ncbi Fourth ventricle central neurocytoma: case report
    Peng Wei Hsu
    First Division of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China
    Neurosurgery 50:1365-7. 2002
    ..Central neurocytomas (CNs) are typically located in the lateral ventricle. Primary origins in the fourth ventricle are very rare. We discuss the clinical symptoms, imaging findings, and microscopic features of these rare tumors...
  59. ncbi Identification of gliomas by morphological and immunocytochemical analysis in cell cultures
    Ilona Fazekas
    National Institute of Neurosurgery, Budapest
    Ideggyogy Sz 55:173-9. 2002
    ..In this study analyses of 124 glioma cases are presented...
  60. ncbi Central neurocytoma: a case study
    Jean Ruppert
    Wallace Kettering Neuroscience Institute, 3533 Southern Boulevard, Suite 5200, Kettering, OH 45429, USA
    J Neurosci Nurs 34:201-4. 2002
    Central neurocytoma (CN) is a rare intraventricular brain tumor that affects young adults. Just over 100 cases of CN have been reported since it was first described in 1982...
  61. ncbi Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implications
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Neuropathol Exp Neurol 61:947-55. 2002
    ..In any case, their occurrence suggests a histogenetic overlap between oligodendroglioma and extraventricular neurocytoma not previously recognized.
  62. ncbi Ventricular diverticula in obstructive hydrocephalus secondary to tumor growth
    Masamitsu Abe
    Department of Neurosurgery, Saga Medical School, Saga, Japan
    Neurosurgery 52:65-70; discussion 70-1. 2003
    ..The association of ventricular diverticula with intra- and paraventricular tumors causing obstructive hydrocephalus has rarely been reported...
  63. ncbi Two cases of atypical central neurocytomas
    Hideo Kuchiki
    Department of Neurosurgery, Yamagata University, School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Brain Tumor Pathol 19:105-10. 2002
    ..a MIB-1 labeling index (LI) greater than 2% and/or vascular proliferation be defined as atypical central neurocytoma (ACN). Two cases of ACN are reported here. Case 1 was a 13-year-old male who complained of headache...
  64. ncbi Linear accelerator radiosurgery for central neurocytoma: a case report
    Chae Yong Kim
    Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    J Neurooncol 61:249-54. 2003
    This study presents a case of central neurocytoma successfully treated with linear accelerator (LINAC)stereotactic radiosurgery...
  65. ncbi Central neurocytoma with craniospinal dissemination
    Hidemasa Takao
    Department of Radiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Neurooncol 61:255-9. 2003
    Central neurocytoma was first described by Hassoun et al. in 1982. The tumor is a rare benign tumor of the central nervous system, usually located in the lateral ventricles. Most reported cases are histologically and clinically benign...
  66. ncbi Dysembryoplastic neuroepithelial tumor or dysembryoplastic cortical neurocytoma?
    J Vaquero
    J Neurooncol 62:359-60; author reply 360. 2003
  67. pmc Angiographic characteristics of central neurocytoma suggest the origin of tumor
    Sun Ha Paek
    Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute Seoul National University Hospital, Seoul, Korea
    J Korean Med Sci 18:573-80. 2003
    The authors retrospectively analyzed the angiographic findings performed in 17 cases with central neurocytoma to document the angiographic characteristics and suggested the origin of tumor based on the angiographic findings...
  68. ncbi [Central neurocytoma: case report]
    P Lehmann
    Service de Radiologie A, CHU Amiens Nord
    J Radiol 84:855-6. 2003
    ..The tumor was initially misdiagnosed as an oligodendroglioma but later proved to be a central neurocytoma. The imaging and histopathological features are reviewed...
  69. ncbi Neuronal nuclear antigen (NeuN): a new tool in the diagnosis of central neurocytoma
    Figen Soylemezoglu
    Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pathol Res Pract 199:463-8. 2003
    ..As the diagnostic criteria for central neurocytoma include immunohistochemical and/or ultrastructural evidence for neuronal differentiation, NeuN as a sensitive ..
  70. ncbi Problematic differential diagnosis between cerebellar liponeurocytoma and anaplastic oligodendroglioma
    C A Valery
    Services de Neurochirurgie, Hopital de la Pitie Salpetriere, Paris, France
    Br J Neurosurg 18:300-3. 2004
    ..The second histological study revealed a liponeurocytoma, a benign tumour not requiring adjuvant therapy. This case emphasizes the importance of considering this diagnosis to prevent unnecessary irradiation of such rumours...
  71. ncbi 201Tl-SPECT and 1H-MRS study of benign lateral ventricle tumors: differential diagnosis of subependymoma
    Tomohiro Kawaguchi
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurosurg Rev 28:96-103. 2005
    ..Our study includes nine cases of benign lateral ventricle tumors including two cases of central neurocytoma, two of subependymal giant cell astrocytoma, two of pilocytic astrocytoma and three of subependymoma treated ..
  72. ncbi Central neurocytoma
    Serguei Bannykh
    Department of Pathology, Yale University School of Medicine, USA
    J Neurooncol 71:31. 2005
  73. ncbi Cerebellar liponeurocytoma
    Brian K Owler
    Department of Neurosurgery and Neurology, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney
    J Clin Neurosci 12:326-9. 2005
    ..The differences in behaviour and prognosis between medulloblastoma and cerebellar liponeurocytoma are presented with the corresponding implications for management...
  74. ncbi Extraventricular neurocytoma presenting with intratumoral hemorrhage
    R Ritz
    Department of Neurosurgery, University Hospital, Eberhard, Germany
    Clin Neuropathol 24:101-5. 2005
    A case of extraventricular neurocytoma with spontaneous intratumoral hemorrhage is reported. A 47-year-old man presented with sudden left-sided hemiparesis...
  75. ncbi [Cerebellar liponeurocytoma. Case report]
    Houda Megdiche Bazarbacha
    Service de Neuroradiologie Institut National de Neurologie, Tunis
    Tunis Med 83:120-2. 2005
    ..The patient has been operated. The histopathological and immunohistochemical studies concluded to a cerebellar liponeurocytoma...
  76. ncbi Haemorrhagic central neurocytoma of the fourth ventricle
    P Gallina
    Department of Neurosurgery, University of Florence, Italy
    Acta Neurochir (Wien) 147:1193-4; discussion 1194. 2005
  77. ncbi [Central neurocytoma: a study of five cases]
    Ayadi Lobna
    Laboratoire d anatolie et de cytologie pathologiques CHU Habib Bourguiba Sfax
    Tunis Med 83:484-7. 2005
    Central neurocytoma is a very rare brain tumour recently described. The diagnosis rests on the data provided by anatomopathological examination and immunohistochemestry...
  78. ncbi Central neurocytoma of the fourth ventricle. Case history
    F Cultrera
    Division of Neurosurgery, M Bufalini Hospital, Cesena, Italy
    J Neurosurg Sci 49:125-8. 2005
    ..We report a rare case of central neurocytoma at the fourth ventricle level...
  79. ncbi Papillary glioneuronal tumor
    Istvan Vajtai
    Department of Clinical Pathology, University of Berne, Switzerland
    Pathol Res Pract 202:107-12. 2006
    ..We perceive PGNT as a clinically and morphologically well-delineated subgroup of extraventricular neurocytic neoplasia, whose paradigmatic presentation may allow for consideration as an entity...
  80. ncbi Central neurocytoma presenting with intraventricular hemorrhage: case report and review of literature
    K Smets
    Department of Neurology, Sint Vincentius Hospital, Antwerp, Belgium
    Acta Neurol Belg 105:218-25. 2005
    ..Anatomopathological analysis revealed a central neurocytoma. Central neurocytoma seldom present with hemorrhage. We review 16 cases of neurocytoma with hemorrhage...
  81. ncbi Comparative analysis of NeuN immunoreactivity in primary brain tumours: conclusions for rational use in diagnostic histopathology
    M Preusser
    Institute of Neurology, Core Unit for Medical Statistics and Informatics, Medical University Vienna, Vienna, Austria
    Histopathology 48:438-44. 2006
    ..Our aim was to perform, for the first time, a systematic and comparative analysis of NeuN expression in all major brain tumour subtypes to provide guidance for the rational use of NeuN immunohistochemistry in diagnostic histopathology...
  82. ncbi Liponeurocytoma of the left lateral ventricle--case report and review of the literature
    K Kuchelmeister
    Institute of Neuropathology, University Hospital Giessen, Germany
    Clin Neuropathol 25:86-94. 2006
    ..Future WHO tumor classification should consider that liponeurocytomas are not restricted to the cerebellum. Reports on cerebellar liponeurocytomas with a less favorable clinical course suggest a WHO grade II for liponeurocytomas...
  83. ncbi Less common indications for stereotactic radiosurgery or fractionated radiotherapy for patients with benign brain tumors
    Jonathan P S Knisely
    Department of Therapeutic Radiology, Yale University School of Medicine, Hunter Radiation Therapy Center, PO Box 208040, New Haven, CT 06520 8040, USA
    Neurosurg Clin N Am 17:149-67, vii. 2006
    ..Patients need to be apprised of all therapeutic options and to make their decisions with all information required to evaluate the risks and benefits. For benign brain tumors, these decisions may have consequences that last for decades...
  84. ncbi Central neurocytoma with unusually high MIB-1 index
    M Ide
    Department of Neurosurgery, Tokyo Women s Medical University Medical Centre East, Tokyo, Japan
    Acta Neurochir (Wien) 148:1217-8. 2006
  85. ncbi Central neurocytoma: a clinico-pathological study of eight cases
    L S Rajesh
    Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012
    Indian J Pathol Microbiol 49:543-5. 2006
    ..The present series highlights the characteristic clinical and pathological findings of this rare brain tumour. Immunostaining for neuronal markers are essential for distinguishing them from other small round cell tumours of the brain...
  86. ncbi OLIG2 is a useful immunohistochemical marker in differential diagnosis of clear cell primary CNS neoplasms
    M Preusser
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Histopathology 50:365-70. 2007
    ..To analyse OLIG2 expression in clear cell primary central nervous system (CNS) tumours to clarify the diagnostic usefulness of OLIG2 immunohistochemistry in this subset of brain tumours...
  87. ncbi [Central neurocytoma: three case reports]
    I Mnif
    Service de Radiologie, EPS Habib Bourguiba, 3029 Sfax, Tunisia
    J Neuroradiol 35:56-9. 2008
    Central neurocytoma is classically recognized as an intraventricular benign brain tumour. Extraventricular localisation is rarer. We report two intraventricular neurocytoma and another bulbar extraventricular neurocytoma...
  88. ncbi Discrepancy between the dynamic computed tomography and T2 magnetic resonance perfusion imaging in brain tumors: a report of 2 cases
    Yao Dong Li
    Department of Radiology, Huashan Hospital, Fudan University School of Medicine, Shanghai, People s Republic of China
    J Comput Assist Tomogr 31:896-900. 2007
    ..resonance perfusion imaging on 2 cases of brain tumors (one was a glioblastoma, and the other was a central neurocytoma)...
  89. doi Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas?
    Tanja Kuhlmann
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Am J Surg Pathol 32:1444-53. 2008
    ..They also support the hypothesis that GBM may be a heterogeneous group of tumors derived from different progenitor cells...
  90. ncbi Correlation of amino-acid uptake using methionine PET and histological classifications in various gliomas
    Kenji Torii
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abenoku, Osaka 545 8585, Japan
    Ann Nucl Med 19:677-83. 2005
    ..If the degree of malignancy of brain tumors can be evaluated by MET-PET, the usefulness of MET-PET as a means of diagnosing brain tumors will increase...
  91. pmc Expression of the splicing regulator polypyrimidine tract-binding protein in normal and neoplastic brain
    Ian E McCutcheon
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neuro Oncol 6:9-14. 2004
    ..astrocytoma, n = 2; anaplastic astrocytoma, n = 2; glioblastoma, n = 4; medulloblastoma, n = 4; central neurocytoma, n = 2; dysplastic gangliocytoma, n = 1; ganglioglioma, n = 1; paraganglioma, n = 1)...
  92. ncbi Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 98:2232-44. 2003
    ..Histologically, it may mimic oligodendroglioma, central neurocytoma, hemangioblastoma, and renal cell carcinoma.
  93. ncbi Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma
    B Quinn
    Department of Pathology, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
    Am J Surg Pathol 22:550-6. 1998
    ..Neuronal differentiation increasingly is recognized in pleomorphic xanthoastrocytoma, intraventricular neurocytoma, and subependymal giant cell astrocytoma...
  94. ncbi [Neuroradiological findings of relatively rare tumors of the brain]
    Noriaki Tomura
    Department of Radiology, Akita University School of Medicine
    Nihon Igaku Hoshasen Gakkai Zasshi 62:463-70. 2002
    ..PXA, subependymoma, gangliocytoma, dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease), DIG, central neurocytoma (CN), neuroblastoma, desmoplastic medulloblastoma, atypical teratoid/rhabdoid tumor (ATRT), glossopharyngeal ..
  95. ncbi Papillary glioneuronal tumor--a new variant of benign mixed brain neoplasm
    Radzisław Kordek
    Department of Pathology, Chair of Oncology, Medical University, Lodz
    Pol J Pathol 54:75-8. 2003
    ..as a contrast enhancing mass with small central hypodense area and consisted of areas similar to central neurocytoma intermixed with vessels surrounded with glial cells...
  96. ncbi [Supratentorial tumors]
    I Grunwald
    Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitatsklinikum des Saarlandes, Homburg
    Radiologe 47:471-85. 2007
    ..tumors include astrocytoma, differentiated by their circumscribed and diffuse growth, ganglioglioma, ependyoma, neurocytoma, primitive neuroectodermal tumors (PNET), oligodendroglioma, dysem-bryoplastic neuroepithelial tumors (DNET), ..
  97. ncbi Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors. Applications in diagnostic neuro-oncology
    T W Smith
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655
    Clin Neuropathol 12:335-42. 1993
    ..and synaptophysin was observed in tumors containing well-differentiated neurons (gangliocytoma, ganglioglioma, neurocytoma)...
  98. ncbi [Revised WHO classification of brain tumours]
    Yoichi Nakazato
    Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Brain Nerve 60:59-77. 2008
    ..Newly codified entities include atypical choroid plexus papilloma, angiocentric glioma, extraventricular neurocytoma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour ..
  99. doi Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report
    Oguz Cataltepe
    Division of Neurosurgery, Department of Surgery, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    J Neurosurg Pediatr 3:456-60. 2009
    ..pathological characteristics of the lesion and reiterate the difficulty in differentiating the histological characteristics of central neurocytoma and DNET in extracortical locations and its significance for further management planning.
  100. doi Clinicopathological analysis of central and extraventricular neurocytoma: a report of 17 cases
    Pengcheng Zhu
    Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 30:746-50. 2010
    b>Neurocytoma, a rare brain tumor, is characterized by a mass located mainly in cerebral ventricles. It is prone to be misdiagnosed as oligodendroglioma or ependymoma due to their similar histopathological features in clinical practice...
  101. doi Leptomeningeal dissemination of a pediatric neoplasm with 1p19q deletion showing mixed immunohistochemical features of an oligodendroglioma and neurocytoma
    Richard B Rhiew
    Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Acta Neurochir (Wien) 152:1425-9. 2010
    ..a 1p19q deletion in a disseminated tumor with mixed immunohistochemical features of oligodendroglioma and neurocytoma was encountered and treated...

Research Grants4

  1. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
  2. Comparative DNA Microarray Analysis of Brain Tumors
    Daniel Brat; Fiscal Year: 2006
    ....
  3. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
    ..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
  4. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..