viral cell transformation

Summary

Summary: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.

Top Publications

  1. ncbi cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells
    A C Vertegaal
    Laboratory for Molecular Carcinogenesis, MGC Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    FEBS Lett 487:151-5. 2000
  2. ncbi EBV Immortalization of human B lymphocytes separated from small volumes of cryo-preserved whole blood
    M M Amoli
    Centre for Integrated Genomic Medical Research, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Int J Epidemiol 37:i41-5. 2008
  3. pmc Loss of robustness and addiction to IGF1 during early keratinocyte transformation by human Papilloma virus 16
    Tamar Geiger
    Unit of Cellular Signaling, Department of Biological Chemistry, Alexander Silverman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 2:e605. 2007
  4. ncbi [Establishment of immortalized B-lymphoblastoid cell lines of keloid pedigree and its karyotype analysis]
    Mei Song
    Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1760-2. 2006
  5. ncbi HTLV-1 Tax and adult T-cell leukemia
    Chou Zen Giam
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Front Biosci 12:1496-507. 2007
  6. ncbi Association of human papillomavirus types 16 and 18 E6 proteins with p53
    B A Werness
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892
    Science 248:76-9. 1990
  7. ncbi Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling
    Christopher W Dawson
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    J Biol Chem 278:3694-704. 2003
  8. pmc Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins
    Shan Lu Liu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 77:2850-8. 2003
  9. ncbi The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature
    Salvador Harguindey
    Centro Médico La Salud, Independencia, 13 01004 Vitoria, Spain
    Biochim Biophys Acta 1756:1-24. 2005
  10. ncbi Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability
    Stefan Duensing
    Department of Pathology, Harvard Medical School, Armenise Research Building, D2 537, 200 Longwood Avenue, Boston, Massachusetts, MA 02115, USA
    Oncogene 21:6241-8. 2002

Research Grants

  1. RESEARCH TRAINING FOR VETERINARY STUDENTS
    Michael Lairmore; Fiscal Year: 2005
  2. MOLECULAR AND ONCOLOGIC VIROLOGY TRAINING PROGRAM
    Daniel DiMaio; Fiscal Year: 2005
  3. ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAIN
    Daniel DiMaio; Fiscal Year: 2004
  4. Mechanism of p12I and p30II in HTLV1 Infection
    Michael Lairmore; Fiscal Year: 2003
  5. Role of HPV16 E7/E2F6 interaction in viral oncogenesis
    Margaret McLaughlin Drubin; Fiscal Year: 2006
  6. The Role of HIV-1 Vpu in the Regulation of CD40
    Ashlee Moses; Fiscal Year: 2009
  7. Identifying cellular genes as anti-HIV drug targets
    Ashlee Moses; Fiscal Year: 2003
  8. ANIMAL MODELS OF MOLECULAR PATHOGENSIS OF HTLV-1
    Michael Lairmore; Fiscal Year: 2003
  9. HIV INFECTED ENDOTHELIUM AND NONHODGKINS LYMPHOMA
    Ashlee Moses; Fiscal Year: 2002
  10. Role of Epstein-Barr virus LMP1 in lymphoma
    KENNETH IZUMI; Fiscal Year: 2009

Detail Information

Publications209 found, 100 shown here

  1. ncbi cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells
    A C Vertegaal
    Laboratory for Molecular Carcinogenesis, MGC Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    FEBS Lett 487:151-5. 2000
    ..This cellular gene was found to be the gene encoding follistatin-related protein, a TGF-beta inducible gene. Consistently, a constitutive factor binding to Smad binding elements was found in adenovirus type 12-transformed cells...
  2. ncbi EBV Immortalization of human B lymphocytes separated from small volumes of cryo-preserved whole blood
    M M Amoli
    Centre for Integrated Genomic Medical Research, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Int J Epidemiol 37:i41-5. 2008
    ..5 ml cryo-preserved whole blood samples. These were EBV transformed in microtitre plates and subsequently expanded in culture. A pilot study within UK Biobank was performed, which confirmed its potential usefulness for this study...
  3. pmc Loss of robustness and addiction to IGF1 during early keratinocyte transformation by human Papilloma virus 16
    Tamar Geiger
    Unit of Cellular Signaling, Department of Biological Chemistry, Alexander Silverman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 2:e605. 2007
    ..We conclude that transformation in this model induces higher susceptibility of cells to stress due to reduced anti-apoptotic signaling and hyper-activation of p53 upon stress...
  4. ncbi [Establishment of immortalized B-lymphoblastoid cell lines of keloid pedigree and its karyotype analysis]
    Mei Song
    Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1760-2. 2006
    ..To establish immortalized B-lymphoblastoid cell lines of keloid pedigree transformed with Epstein-Barr (EB) virus and conduct karyotype analysis of the cells...
  5. ncbi HTLV-1 Tax and adult T-cell leukemia
    Chou Zen Giam
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Front Biosci 12:1496-507. 2007
    ....
  6. ncbi Association of human papillomavirus types 16 and 18 E6 proteins with p53
    B A Werness
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892
    Science 248:76-9. 1990
    ....
  7. ncbi Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling
    Christopher W Dawson
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    J Biol Chem 278:3694-704. 2003
    ....
  8. pmc Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins
    Shan Lu Liu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 77:2850-8. 2003
    ....
  9. ncbi The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature
    Salvador Harguindey
    Centro Médico La Salud, Independencia, 13 01004 Vitoria, Spain
    Biochim Biophys Acta 1756:1-24. 2005
    ....
  10. ncbi Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability
    Stefan Duensing
    Department of Pathology, Harvard Medical School, Armenise Research Building, D2 537, 200 Longwood Avenue, Boston, Massachusetts, MA 02115, USA
    Oncogene 21:6241-8. 2002
    ..These findings suggest that HPV oncoprotein-induced chromosomal instability increases the risk for genetic changes that may ultimately facilitate carcinogenic progression...
  11. ncbi Transformation of normal human cells in the absence of telomerase activation
    Yvette R Seger
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cancer Cell 2:401-13. 2002
    ..Notably, transformation did not require telomerase activation. Therefore, we provide evidence that activation of telomere maintenance strategies is not an obligate characteristic of tumorigenic human cells...
  12. pmc Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines
    Jason S Knight
    Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia 19104, USA
    J Virol 77:4261-72. 2003
    ..Clearly, EBNA3C functions as a component of a number of dynamic complexes which function in repression and activation of transcription...
  13. pmc Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus
    Alla Danilkovitch-Miagkova
    Laboratory of Immunobiology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 100:4580-5. 2003
    ..We find activated RON in a subset of human bronchioloalveolar carcinoma tumors, suggesting RON involvement in this type of human lung cancer...
  14. pmc microRNAs in viral oncogenesis
    Vinod Scaria
    Retrovirology 4:82. 2007
    ..The host-virus crosstalk mediated by microRNAs, messenger RNAs and proteins, is complex and involves the different cellular regulatory layers. In this commentary, we describe models of microRNA mediated viral oncogenesis...
  15. ncbi E2F: a link between the Rb tumor suppressor protein and viral oncoproteins
    J R Nevins
    Howard Hughes Medical Institute, Section of Genetics, Duke University Medical Center, Durham, NC 27710
    Science 258:424-9. 1992
    ....
  16. ncbi Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma
    Hui Zheng
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    Cell Mol Immunol 4:185-96. 2007
    ..Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC...
  17. pmc Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase
    Laurent Lefebvre
    Faculty of Agronomy, Gembloux, Belgium
    J Virol 76:1400-14. 2002
    ..Identification of FPPS as a molecular partner for p13(II) and G4 accessory proteins opens new prospects for treatment of retrovirus-induced leukemia...
  18. pmc Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation
    S K Rai
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 98:4443-8. 2001
    ..The finding that JSRV env is oncogenic and the identification of HYAL2 as the JSRV receptor provide tools for further investigation of the mechanism of JSRV oncogenesis and its relationship to human bronchiolo-alveolar carcinoma...
  19. pmc Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence
    Yu Liang Kuo
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    EMBO J 25:1741-52. 2006
    ..Finally, activation of APC ahead of schedule may be exploited to arrest cancer cell growth...
  20. ncbi Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
    Masao Matsuoka
    Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Japan
    Nat Rev Cancer 7:270-80. 2007
    ..We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia...
  21. pmc Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation
    Michael D Lairmore
    Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210 1093, USA
    Oncogene 24:6005-15. 2005
    ..Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma...
  22. ncbi PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line
    Akira Hirata
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Virology 318:327-36. 2004
    ....
  23. ncbi Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1
    Hyeon Ung Park
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 23:4966-74. 2004
    ..The G(2) arrest did not require Chk2 or p53. These studies provide the first example of a viral transforming protein targeting Chk1 and provide important insights into checkpoint pathway regulation...
  24. pmc Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication
    Blanca Lupiani
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 101:11815-20. 2004
    ..A revertant virus that restored the expression of the meq gene, showed properties similar to those of the parental virus, confirming that Meq is involved in transformation but not in lytic replication in chickens...
  25. pmc Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Virol 81:11900-7. 2007
    ....
  26. pmc Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation
    Joshua Arnold
    Center for Retrovirus Research, Department of Veterinary Biosciences and Molecular Virology Immunology, The Ohio State University, Columbus, OH 43210, USA
    Blood 112:3788-97. 2008
    ..Our data indicate that Hbz expression enhances the proliferative capacity of HTLV-1-infected T cells, playing a critical role in cell survival and ultimately HTLV-1 tumorigenesis in the infected host...
  27. ncbi Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells
    Kathryn S Jones
    Basic Research Program, Science Applications International Corporation Frederick, Frederick, Maryland 21702, USA
    Nat Med 14:429-36. 2008
    ..In addition to altering the current paradigm concerning how HTLV-1 transmission occurs, these studies suggest that impairment of DC function after HTLV-1 infection plays a part in pathogenesis...
  28. pmc Recombinant Marek's disease virus (MDV)-derived lymphoblastoid cell lines: regulation of a marker gene within the context of the MDV genome
    M S Parcells
    Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    J Virol 73:1362-73. 1999
    ..Our results indicate that regulation of the lacZ marker gene can serve as sensitive measure of virus lytic-phase induction and the reactivation from latency...
  29. pmc Centrosome and retroviruses: the dangerous liaisons
    Philippe V Afonso
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Departement de Virologie, Institut Pasteur, Paris, France
    Retrovirology 4:27. 2007
    ..Enthrallingly, HTLV-1 Tax expression also targets the functions of the centrosome, and this event is correlated with centrosome amplification, aneuploidy and transformation...
  30. pmc Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax
    Keiichi Endo
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Virol 76:2648-53. 2002
    ..Our results showed that Tax2 has a lower transforming activity than Tax1 and suggest that the high transforming activity of Tax1 is involved in the leukemogenic property of HTLV-1...
  31. ncbi Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style
    J L Liu
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    Virus Genes 21:51-64. 2000
    ..In this review, we will attempt to summarize the past research progress on MDV meq, with a focused on the similarities and differences between MEQ and cellular proteins, and between MEQ and other viral oncoproteins...
  32. ncbi GITR overexpression on CD4+CD25+ HTLV-1 transformed cells: detection by massively parallel signature sequencing
    Harshawardhan P Bal
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    Biochem Biophys Res Commun 332:569-84. 2005
    ....
  33. pmc Epstein-Barr virus with the latent infection nuclear antigen 3B completely deleted is still competent for B-cell growth transformation in vitro
    Adrienne Chen
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 79:4506-9. 2005
    ..Deletion of the entire EBNA-3B open reading frame from the EBV BAC had no adverse impact on growth of EBV-immortalized B cells, providing formal proof that EBNA-3B is not essential for EBV-mediated B-cell growth transformation in vitro...
  34. ncbi Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus
    Masanobu Sugimoto
    GeneCare Research Institute, Kanagawa, Japan
    Cancer Res 64:3361-4. 2004
    ..The new concept as reviewed here is essential for the future study of tumorigenesis by EBV...
  35. ncbi Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 281:8927-38. 2006
    ..Tax is shown to activate activator protein-1 through the phosphatidylinositol 3-kinase/Akt pathway...
  36. pmc Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus
    Andrew C Brown
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    Proc Natl Acad Sci U S A 103:1687-92. 2006
    ..Engineering MDV with precisely defined attenuating mutations, therefore, represents an effective strategy for generating new vaccines against this major poultry disease...
  37. pmc HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro
    Jianxin Ye
    The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
    Blood 102:3963-9. 2003
    ..However, Rex is critical for efficient infection of cells and persistence in vivo...
  38. ncbi Differential cytotoxicity of anticancer agents in pre- and post-immortal lymphoblastoid cell lines
    Kaori Sawada
    GeneCare Research Institute, Kanagawa, Japan
    Biol Pharm Bull 28:1202-7. 2005
    ..Based on these results, we propose that pre-N0005 and post-N0005 cell lines be used as a new method to assess and screen anticancer agents...
  39. pmc Methylation status of the Epstein-Barr virus (EBV) BamHI W latent cycle promoter and promoter activity: analysis with novel EBV-positive Burkitt and lymphoblastoid cell lines
    Isabel A Hutchings
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Virol 80:10700-11. 2006
    ..Thus, studies of B cells with atypical patterns of Wp usage emphasize the strong correlation between the presence of unmethylated Wp sequences and promoter activity...
  40. ncbi Accelerated G(1) phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoprotein
    F J Lemoine
    Interdepartmental Program of Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:31851-7. 2001
    ..Tax-associated acceleration of cell cycle progression may play a role in the ability of this viral oncoprotein to mediate cellular transformation and promote the development of human T cell leukemia virus type I-associated diseases...
  41. pmc A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis
    Sascha Trapp
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    J Exp Med 203:1307-17. 2006
    ..We concluded that vTR plays a critical role in MDV-induced T cell lymphomagenesis. Furthermore, our results provide the first description of tumor-promoting effects of TR in a natural virus-host infection model...
  42. ncbi Oncogenic gamma-herpesviruses: comparison of viral proteins involved in tumorigenesis
    Blossom Damania
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nat Rev Microbiol 2:656-68. 2004
  43. ncbi Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cells
    Hongyi Pan
    Tumor Virology Program, Children Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, 78229, USA
    Cancer Res 64:4064-8. 2004
    ..Our results indicate that KSHV infection could predispose cells to malignant transformation through induction of genomic instability and contributes to the development of KS...
  44. ncbi NFkappaB signaling is induced by the oncoprotein Tio through direct interaction with TRAF6
    Stefanie Heinemann
    Institut fur Klinische und Molekulare Virologie, Friedrich Alexander Universitat Erlangen Nurnberg, Schlossgarten 4, 91054 Erlangen, Germany
    J Biol Chem 281:8565-72. 2006
    ..Furthermore, we provide evidence that TRAF6 directly binds to the Tio oncoprotein. Identification of TRAF6 as the direct target of Tio describes a novel mechanism for the constitutive activation of NFkappaB through an oncoprotein...
  45. pmc Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein
    Kojiro Ishioka
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Retrovirology 3:71. 2006
    ..The interaction of human T-cell leukemia virus type 1 (HTLV-1) Tax1 protein with the tumor suppressor Dlg1 is correlated with cellular transformation...
  46. ncbi Proliferation and differentiation in isogenic populations of peripheral B cells activated by Epstein-Barr virus or T cell-derived mitogens
    Jenny O'Nions
    Department of Virology and Ludwig Institute for Cancer Research, Wright Fleming Institute, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK
    J Gen Virol 85:881-95. 2004
    ..The study has also identified a window of opportunity during which a comparison of isogenic populations of EBV- and mitogen-driven B blasts can be made...
  47. ncbi Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3
    Minako Ohashi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Virology 320:52-62. 2004
    ..Our results suggest that the interaction of Tax1 and MAGI-3 alters their respective biological activities, which may play a role in transformation by Tax1 as well as in the pathogenesis of HTLV-1-associated diseases...
  48. ncbi Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis
    Renee M Overmeer
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Pathol 219:327-36. 2009
    ..Hence, MAL promoter methylation and/or mRNA expression analysis on cervical scrapings may provide a valuable diagnostic tool to improve the detection of CIN3, SCC, and AdCA...
  49. ncbi B cells under influence: transformation of B cells by Epstein-Barr virus
    Ralf Kuppers
    Institute for Genetics, Department of Internal Medicine I, University of Cologne, 50931 Cologne, Germany
    Nat Rev Immunol 3:801-12. 2003
    ....
  50. ncbi Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells
    Takayuki Nitta
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Cancer Sci 97:836-41. 2006
    ..These findings suggest that Tax deregulates CDK activity and induces centrosome amplification, which might be associated with cellular transformation by HTLV-1 and chromosomal instability in HTLV-1-infected human T cells...
  51. ncbi Signal transduction pathways utilized by enzootic nasal tumor virus (ENTV-1) envelope protein in transformation of rat epithelial cells resemble those used by jaagsiekte sheep retrovirus
    Naoyoshi Maeda
    Cancer Research Institute, University of California, Irvine, Sprague Hall, Irvine, CA 92697 3900, USA
    Virus Genes 36:147-55. 2008
    ..These results indicate that the signaling pathways for ENTV and JSRV transformation are quite similar, consistent with the notion that these proteins do not determine the tissue-specificity of the tumors for these viruses...
  52. pmc PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo
    Li Xie
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
    Blood 107:1980-8. 2006
    ....
  53. pmc In vivo tumorigenesis by Jaagsiekte sheep retrovirus (JSRV) requires Y590 in Env TM, but not full-length orfX open reading frame
    Chris Cousens
    Moredun Research Institute, Pentlands Science Park, Penicuik, Edinburgh, UK
    Virology 367:413-21. 2007
    ..In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV(21)...
  54. pmc Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2
    A Dusty Miller
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    BMC Cancer 4:64. 2004
    ..When Env was expressed it bound to Hyal2 causing its degradation, release of RON activity from Hyal2 suppression, and activation of pathways resulting in cell transformation...
  55. ncbi Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells
    J F Charlot
    Universite de Franche Comte, UFR Médecine et Pharmacie, EA 3181, IFR 133 19 rue Ambroise Paré, 25000 Besancon, France
    Apoptosis 11:813-27. 2006
    ..Moreover, Pifithrin-alpha could be used in combination with ST and PRIMA-1 to prevent side effects of anti-tumor therapies in cells expressing mutant P53...
  56. ncbi HBZ, a new important player in the mystery of adult T-cell leukemia
    Jean Michel Mesnard
    Laboratoire Infections Retrovirales et Signalisation Cellulaire, Centre National de la Recherche Scientifique CNRS Unité mixte de recherche UMR 5121 UM1, Montpellier, France
    Blood 108:3979-82. 2006
    ..One report suggests that the HBZ gene might have a bimodal function (at the mRNA and protein levels), which could represent an uncharacterized strategy to regulate viral replication and proliferation of infected T cells...
  57. pmc In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma
    Agata D Agostino Mutlu
    Laboratory of Viral Oncogenesis, Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cancer Cell 11:245-58. 2007
    ..These results show that KSHV malignancy is in vivo growth restricted and reversible, defining mECK36 as a biologically sensitive animal model of KSHV-dependent KS...
  58. pmc CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell lines
    H M Long
    CRUK Institute for Cancer Studies, The University of Birmingham, Vincent Dr, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Virol 79:4896-907. 2005
    ..Thus, while CD4+ T-cell responses are detectable against many epitopes in EBV latent proteins, only a minority of these responses are likely to have therapeutic potential as effectors directly recognizing latently infected target cells...
  59. ncbi Copy number increase of 1p36.33 and mitochondrial genome amplification in Epstein-Barr virus-transformed lymphoblastoid cell lines
    Jae Pil Jeon
    Biobank for Health Sciences, Center for Genome Science, National Institute of Health, Korea Center for Disease Control and Prevention, 5 Nokbun, Eunpyung Gu, Seoul 122 701, Republic of Korea
    Cancer Genet Cytogenet 173:122-30. 2007
    ..33 due to increased mitochondrial DNA copy numbers. Thus, analyses of array CGH profiles of diseases should take into account the potential for copy number variation of 1p36.33...
  60. pmc Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines
    Naoyoshi Maeda
    Cancer Research Institute, University of California, Irvine, Irvine, CA 92697 3900, USA
    J Virol 79:4440-50. 2005
    ....
  61. ncbi Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy
    Vincent Moules
    Oncovirologie et Biothérapies, UMR5537 CNRS Université Claude Bernard, Centre Leon Berard, Lyon, France
    Cancer Res 65:1234-43. 2005
    ..5 to 60 months of clinical latency, when a dramatic decrease in the genetic instability of premalignant cells coincided with a rapid increase in lymphocyte count and lymphoma onset...
  62. ncbi A methylation profile of in vitro immortalized human cell lines
    Limin Liu
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Int J Oncol 26:275-85. 2005
    ..In general, more genes were methylated in neoplastically-transformed cell lines than in only immortalized cell lines, indicating that accumulation of epigenetic abnormalities may contribute to oncogenesis...
  63. pmc Multiple domains of the Jaagsiekte sheep retrovirus envelope protein are required for transformation of rodent fibroblasts
    Andrew Hofacre
    Cancer Research Institute, Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697 3905, USA
    J Virol 78:10479-89. 2004
    ..The resulting transformants showed evidence for the presence and expression of both mutant plasmids...
  64. ncbi Oncogenesis by retroviruses: old and new paradigms
    Naoyoshi Maeda
    Division of Host Defense, Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    Rev Med Virol 18:387-405. 2008
    ..In this review, we will summarise research on retrovirus oncogenic transformation over the past 100 years since the first published report of an oncogenic virus with particular attention to Env-induced transformation...
  65. pmc Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require phosphatidylinositol 3-kinase
    Naoyoshi Maeda
    Cancer Research Institute, University of California Irvine, Irvine, CA 92697 3000, USA
    J Virol 77:9951-9. 2003
    ..Therefore, JSRV envelope can induce PI3K-independent phosphorylation of Akt...
  66. pmc A phosphatidylinositol 3-kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced transformation of NIH 3T3 cells
    M Palmarini
    Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, 30602, USA
    J Virol 75:11002-9. 2001
    ....
  67. ncbi Kinetic and phenotypic changes in murine lymphocytes infected with murine gammaherpesvirus-68 in vitro
    B M Dutia
    Department of Veterinary Pathology, University of Edinburgh, Summerhall, UK
    J Gen Virol 80:2729-36. 1999
    ..This DNA was nuclease sensitive, indicating that, while MHV-68 was efficiently uncoated, its circularization in vitro was extremely inefficient. These results are discussed in terms of the host-virus interaction...
  68. ncbi Human T-cell leukemia virus type 1 tax protein activates transcription through AP-1 site by inducing DNA binding activity in T cells
    K Iwai
    Department of Virology, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan
    Virology 279:38-46. 2001
    ..Our results suggest that Tax activates the transcription of cellular genes with AP-1 sites by inducing the DNA-binding activity of AP-1 proteins in T cells, a mechanism distinct from those of CRE-like and kappaB elements...
  69. ncbi Multiple viral strategies of HTLV-1 for dysregulation of cell growth control
    M Yoshida
    Banyu Tsukuba Research Institute, Tsukuba, Ibaraki 300 2611, Japan
    Annu Rev Immunol 19:475-96. 2001
    ..This is an effective viral strategy to amplify its proviral genome through replication of infected cells; ultimately it results in cell transformation and leukemogenesis...
  70. pmc Envelope-induced cell transformation by ovine betaretroviruses
    Alberto Alberti
    Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Virol 76:5387-94. 2002
    ..In addition, phosphorylated Akt was detected in a cell line derived from a lung tumor of a sheep with naturally occurring ovine pulmonary adenocarcinoma...
  71. pmc Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA
    N Maeda
    Cancer Research Institute and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 98:4449-54. 2001
    ..These results indicate that the envelope gene carries the transforming potential. This is an unusual example of a native retroviral structural protein with transformation potential...
  72. ncbi Interferon--gamma control of EBV-transformed B cells: a role for CD8+ T cells that poorly kill EBV-infected cells
    Yan Shi
    Department of Pathology, University of Iowa, Iowa City 52242 1182, USA
    Viral Immunol 15:213-25. 2002
    ..Inhibitory factor activity was neutralized by anti-IFN-gamma monoclonal antibodies (mAb), but not by antibodies to several other cytokines. These data suggest an in vivo role for IFN-y secreting EBV-specific CD8+ T cells...
  73. ncbi LMP1 structure and signal transduction
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham, B15 2TA, UK
    Semin Cancer Biol 11:435-44. 2001
    ..The constitutive engagement of these signals and the characteristic molecular interactions that regulate them provide the basis for the molecular explanation of the transforming properties of this key EBV protein...
  74. pmc Mechanism of cell entry and transformation by enzootic nasal tumor virus
    Clarissa Dirks
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    J Virol 76:2141-9. 2002
    ..The transcriptional regulatory elements in these viruses are quite different, indicating that tissue-specific oncogenesis is likely regulated at the level of viral gene expression...
  75. ncbi The ubiquitin/proteasome system in Epstein-Barr virus latency and associated malignancies
    Nico P Dantuma
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 17177 Stockholm, Sweden
    Semin Cancer Biol 13:69-76. 2003
    ..Knowledge of these multiple strategies of interference with regulated proteolysis may provide new clues for the treatment of EBV-associated malignancies...
  76. ncbi Telomerase activity in high-grade cervical lesions is associated with allelic imbalance at 6Q14-22
    Mark van Duin
    Department of Pathology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Int J Cancer 105:577-82. 2003
    ..These data suggest that 6q14-22 may contain 1 or more genes involved in telomerase deregulation and immortalization during cervical carcinogenesis...
  77. ncbi Evidence for a putative senescence gene locus within the chromosomal region 10p14-p15
    M Poignee
    Gynäkologische Molekularbiologie, Abteilung Frauenheilkunde, Frauenklinik der Friedrich Schiller Universität Jena, 07743 Jena, Germany
    Cancer Res 61:7118-21. 2001
    ..The potential significance of loss of gene function in this region is underlined by the high frequency (38.7%) of loss of heterozygosity in cervical cancers including early stage tumors...
  78. pmc Transformation of rodent fibroblasts by the jaagsiekte sheep retrovirus envelope is receptor independent and does not require the surface domain
    Yen Hung J Chow
    Department of Medical Microbiology and Parasitology and Comparative Oncology Program, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    J Virol 77:6341-50. 2003
    ..Taken together these results indicate that the interaction with Hyal-2 at least is not an essential determinant of JSRV-induced transformation of fibroblasts and that the viral TM functions essentially as an oncoprotein...
  79. pmc Putative phosphatidylinositol 3-kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt activation
    Shan Lu Liu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Virol 77:7924-35. 2003
    ..We conclude that ovine betaretrovirus Env proteins transform the rodent fibroblasts by indirectly activating the PI3K/Akt pathway...
  80. ncbi EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells
    Elena Kashuba
    Microbiology and Tumor Biology Center MTC, Karolinska Institute, Nobels vag 16, Box 280, S 171 77 Stockholm, Sweden
    Int J Cancer 105:644-53. 2003
    ..The inclusions also contained p53 and HDM2, and were surrounded by PML bodies and proteasomes, which suggests that these inclusions could be targets for proteasome dependent protein degradation...
  81. ncbi Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirus
    Guillermo Zavala
    Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Virology 312:95-105. 2003
    ..As a whole, these results suggest that the activation of the PI-3K/Akt pathway contributes to the process of JSRV-induced cell transformation but most likely is not the primary determinant both in vitro and in vivo...
  82. ncbi Establishment of permanent cell lines by Epstein-Barr virus transformation
    J Gilbert
    Duke University Medical Center, Durham, North Carolina, USA
    Curr Protoc Hum Genet . 2001
    ..Virus stocks are prepared from cultures of an infected marmoset cell line in the first support protocol. Transformed cells may be analyzed immediately or frozen for future use as described in the second support protocol...
  83. ncbi Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus
    Marsilio Adriani
    Department of Pediatrics, Federico II University, Naples, Italy
    J Immunol 177:6889-95. 2006
    ..These data also confirm that growth failure in X-SCID is primarily related to the genetic alteration of the IL2RG gene...
  84. ncbi Role of Epstein-Barr virus-encoded latent membrane protein 2A on virus-induced immortalization and virus activation
    K Konishi
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, 060-8638 Sapporo, Japan
    J Gen Virol 82:1451-6. 2001
    ..The results raise a question as to the role of LMP2A in inhibition of disruption of virus latency in vivo, where LMP2A expression has been expected to be low as in Akata cells...
  85. ncbi Immortalization of Epstein-Barr virus-negative human B lymphocytes with minimal chromosomal instability
    Yoriko Yamashita
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Int 56:659-67. 2006
    ..Furthermore, using this system, it is possible to analyze the role of individual genes in human B lymphocyte immortalization without the influence of a pre-existing Epstein-Barr virus genome...
  86. ncbi Long-term expression of a transferred gene in Epstein-Barr virus transformed human B cells
    G X Shi
    Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    Scand J Immunol 54:265-72. 2001
    ....
  87. ncbi Generation of Epstein-Barr Virus (EBV)-immortalized B cell lines
    Giovanna Tosato
    National Cancer Institute, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2007
    ..The protocol described in this unit to accomplish this can be divided into three stages: preparation of virus, preparation of target cells to be immortalized, and EBV infection and growth of infected cells...
  88. ncbi EBV-specific CD4+ T cell clones exhibit vigorous allogeneic responses
    Elise Landais
    Institut National de la Sante et de la Recherche Medicale, Unite 601, Institut de Biologie, Nantes, France
    J Immunol 177:1427-33. 2006
    ..As already proposed, the strong alloreactivity toward LCLs suggest that these cells could be used for selective depletion of alloreactive T cells...
  89. ncbi Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
    ..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
  90. ncbi Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis
    Y C Kim
    Department of Biochemistry, Yonsei University, 134 Shinchondong, Seodaemungu, Seoul, Korea 120-749
    Oncogene 20:16-23. 2001
    ..Data presented here firmly established the oncogenic potential of HBx during multistage carcinogenesis. Oncogene (2001) 20, 16 - 23...
  91. ncbi Cell cycle arrest and lytic induction of EBV-transformed B lymphoblastoid cells by a histone deacetylase inhibitor, Trichostatin A
    J S Seo
    Research Institute of Immunobiology, Catholic University, Seoul 137 701, Japan
    Oncol Rep 19:93-8. 2008
    ..These results suggest that TSA may exert an enhanced anti-tumor effect for EBV-associated tumors not only by inducing a cell cycle arrest and apoptosis, but also by triggering an EBV lytic cycle...
  92. pmc The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation
    K M Izumi
    Department of Medicine, Brigham and Women s Hospital, and Channing Laboratories, Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115 5804, USA
    Mol Cell Biol 19:5759-67. 1999
    ..These results add a different perspective to the molecular interactions through which LMP1, TRADD, and RIP participate in B-lymphocyte activation and growth...
  93. ncbi The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus
    Helmut Kutz
    GSF National Research Center for Environment and Health, Department of Gene Vectors, Marchioninistrasse 25, D 81377 Munich, Germany
    Virology 371:246-56. 2008
    ..Our data support a critical role of the LMP1-induced JNK pathway for proliferation of LMP1-transformed cells and characterize JNK as a potential target for intervention against EBV-induced malignancies...
  94. ncbi Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant
    J E Cleaver
    Department of Dermatology, University of California at San Francisco, 94143 0750, USA
    Cancer Res 59:1102-8. 1999
    ..The symptoms of elevated solar carcinogenesis in XPV patients may, therefore, be associated with increased genomic instability in cells of the skin in which p53 is inactivated by UV-induced mutations...
  95. pmc The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB
    K M Izumi
    Department of Microbiology and Molecular Genetics, Harvard Medical School and Medicine, Brigham and Women s Hospital, Eighth Floor Channing Laboratories, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:12592-7. 1997
    ..These results indicate that LMP1 appropriates TRADD to enable efficient long-term lymphoblastoid cell outgrowth. High-level NF-kappaB activation also appears to be a critical component of long-term outgrowth...
  96. ncbi Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells
    X J Guo
    Cancer Research Laboratory, University of Western Ontario, London, Canada
    Cell Growth Differ 1:333-8. 1990
    ..In addition, high 5B10 mRNA levels were associated with metastatic ability in a series of ras-transformed cells, in proportion to levels of ras p21 expressed by the cells, implicating 5B10 even more deeply in carcinogenesis...
  97. pmc NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells
    E D Cahir-McFarland
    The Channing Laboratory and Department of Infectious Diseases, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02130, USA
    Proc Natl Acad Sci U S A 97:6055-60. 2000
    ..However, caspase inhibition failed to block apoptosis. These experiments indicate that NF-kappaB inhibitors may be useful in the therapy of EBV-induced cellular proliferation...
  98. ncbi Differential regulation of human RecQ family helicases in cell transformation and cell cycle
    T Kawabe
    AGENE Research Institute, Kamakura, Kanagawa, Japan
    Oncogene 19:4764-72. 2000
    ..Our results support the view that the levels of WRN, BLM, RTS and RecQL1 are differentially up-regulated to guarantee genomic stability in cells that are transformed or actively proliferating...
  99. ncbi Generation of continuously growing B cell lines by epstein-barr virus transformation
    W E Biddison
    National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA
    Curr Protoc Cell Biol . 2001
    ..In this unit, Epstein-Barr virus produced by a marmoset cell line is used to transform B cells into a continuously growing cell line that produces no virus. These cell lines can be used as a constant source of cells for further study...
  100. ncbi Quantitative analysis of human leucocyte antigen expression during culture of Epstein-Barr virus-transformed cell lines using the dako QIFIKIT
    R Battle
    Transplant Immunology, St James University Hospital, Leeds
    Br J Biomed Sci 64:32-4. 2007
    ....
  101. pmc Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation
    S C Murthy
    New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772
    J Virol 63:3307-14. 1989
    ..5 kilobases). Although some analogies can be drawn between STP and LMP (lymphocyte membrane protein) of Epstein-Barr virus, STP is not related in sequence to LMP...

Research Grants64

  1. RESEARCH TRAINING FOR VETERINARY STUDENTS
    Michael Lairmore; Fiscal Year: 2005
    ....
  2. MOLECULAR AND ONCOLOGIC VIROLOGY TRAINING PROGRAM
    Daniel DiMaio; Fiscal Year: 2005
    ..In these capacities, he is well positioned to foster interactions among other members of the faculty in the School of Medicine. ..
  3. ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAIN
    Daniel DiMaio; Fiscal Year: 2004
    ..These experiments should provide new insights into the function and regulation of receptor tyrosine kinases and into human tumorigenesis, and they should elucidate the binding properties of a new family of WW domains. ..
  4. Mechanism of p12I and p30II in HTLV1 Infection
    Michael Lairmore; Fiscal Year: 2003
    ..Our long-term goal is to understand the role of p12-I and p30-II in the establishment of HTLV-1 infection in vivo. ..
  5. Role of HPV16 E7/E2F6 interaction in viral oncogenesis
    Margaret McLaughlin Drubin; Fiscal Year: 2006
    ..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  6. The Role of HIV-1 Vpu in the Regulation of CD40
    Ashlee Moses; Fiscal Year: 2009
    ..Successful completion of these Aims will lead to an increased understanding of both CD40 regulation and Vpu function, and may identify targets of immune modulatory and/or anti-viral significance. ..
  7. Identifying cellular genes as anti-HIV drug targets
    Ashlee Moses; Fiscal Year: 2003
    ..The company intends to develop intellectual property protection for the use of novel validated genes in antiviral drug assays, and pursue the development of such drugs. ..
  8. ANIMAL MODELS OF MOLECULAR PATHOGENSIS OF HTLV-1
    Michael Lairmore; Fiscal Year: 2003
    ..Collectively, our research groups provide a coordinated approach to develop state-of-the-art animal models to further knowledge of the events of HTLV-1 pathogenesis. ..
  9. HIV INFECTED ENDOTHELIUM AND NONHODGKINS LYMPHOMA
    Ashlee Moses; Fiscal Year: 2002
    ..Identification of these mechanisms may suggest therapeutic targets to prevent development of extranodal B cell neoplasms. ..
  10. Role of Epstein-Barr virus LMP1 in lymphoma
    KENNETH IZUMI; Fiscal Year: 2009
    ....
  11. Molecular Therapy Core Centers
    Arthur Miller; Fiscal Year: 2008
    ..abstract_text> ..
  12. Carl Zeiss LSM 510 Confocal Inverted Microscope System
    Chou Zen Giam; Fiscal Year: 2008
    ..This instrumentation request is thus of obvious importance to the overall mission of the NIH, to fund research that will improve public health. [unreadable] [unreadable] [unreadable]..
  13. 2007 Molecular Biology of Hepatitis B Viruses Meeting
    William Mason; Fiscal Year: 2007
    ..Limited support for meeting materials and organizational[unreadable] functions is also needed. ..
  14. ROLE OF AMPK IN TUMOR DEVELOPMENT AND THERAPY
    Keith R Laderoute; Fiscal Year: 2010
    ..Ultimately, we intend to determine whether the AMPK "emergency stress response" can be exploited for the therapy or prognosis of human cancer. ..
  15. Identifying small molecule inhibitors of KSHV vFLIP-TRAF2 interactions.
    Ethel Cesarman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Phenotypes of HIV-1 Integrases
    William Robinson; Fiscal Year: 2009
    ..Inhibitors of integrase are in clinical testing. Understanding how HIV becomes resistant to these compounds and how such compounds interact with integrase are fundamental to the synthesis of better anti-HIV drugs. ..
  17. Herpes Simplex Virus Transmission Across Cell Junctions
    David Johnson; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. SULFATE CONJUGATION AND DRUG METABOLISM
    Richard Weinshilboum; Fiscal Year: 2007
    ....
  19. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  20. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..This project will determine the prevalence of RANTES as a novel IC biomarker in urines and then quantify the efficacy of mechanistically-directed therapies in murine models. ..
  21. Oncogenic properties of interferon regulatory factor 7
    Luwen Zhang; Fiscal Year: 2009
    ..This study should provide an insight of how IRF-7 participates in EBV transformation, and expand our knowledge about IRFs as well as the pathogenesis of EBV-associated CNS lymphoma. ..
  22. Macrophages Role in the Development of HIV Lipoatrophy
    Deirdre Killebrew; Fiscal Year: 2008
    ..abstract_text> ..
  23. Developmental Checkpoints of Murine Mast Cells
    Koichi Akashi; Fiscal Year: 2009
    ..Results obtained from this project will be critical to study mast cell biology, which eventually will help develop new therapeutic strategies for a variety of allergic and autoimmune disorders. ..
  24. FUNCTIONS OF E2A IN B LYMPHOCYTE DEVELOPMENT
    Yuan Zhuang; Fiscal Year: 2009
    ..abstract_text> ..
  25. Role of Wnt signaling in Cervical Cancer Pathogenesis
    Aykut Uren; Fiscal Year: 2010
    ..Aykut The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  26. Computer Simulation of Epstein Barr Virus Infection
    David Thorley Lawson; Fiscal Year: 2009
    ..e. cure) of the virus is realistic or even possible. ..
  27. Virus Specific CTL following T cell depleted SCT
    Kenneth Lucas; Fiscal Year: 2009
    ....
  28. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  29. HYPOXIC STRESS MECHANISMS IN RADIATION AND CHEMOTHERAPY
    Keith Laderoute; Fiscal Year: 2009
    ..An understanding of these MTF-1-dependent properties should aid in the development of novel prognostic and new modalities for neoplastic diseases. ..
  30. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2008
    ..In this fashion we hope to establish whether Myc-induced genomic instability merits wider exploration in human neoplasm. [unreadable] [unreadable] [unreadable] [unreadable]..
  31. Epstein-Barr Virus: Activation of WNT
    Nancy Raab Traub; Fiscal Year: 2008
    ..A detailed understanding of the activation of this pathway may provide new opportunities for treatment of EBV-associated cancers and also of similar cancers considered EBV-negative, that develop in the immunosuppressed. ..
  32. Lineage decision in blood stem and progenitor cells
    Koichi Akashi; Fiscal Year: 2007
    ..Thus, we hope these studies will help understand mechanistic effects of these transcription factors on lineage decision in normal and malignant hematopoietic development. ..
  33. KSHV TRANSFORMATION AND ANGIOGENESIS IN KAPOSIS SARCOMA
    Ethel Cesarman; Fiscal Year: 2001
    ..These studies will also provide information that will enrich our general knowledge of viral oncogenesis. ..
  34. BD FACSAria Flow Cytometer Cell Sorter
    Chou Zen Giam; Fiscal Year: 2005
    ..Sorting time may be made available to investigators outside of the USUHS community from time to time when the instrument would otherwise not be used. ..
  35. NK AND T CELL COSTIMULATION BY NKG2D/DAP10
    LEWIS LANIER; Fiscal Year: 2005
    ..Given the broad distribution of MICA/B on freshly isolated human tumors, studies of the NKG2D-DAP10 receptor may provide new opportunities for immunotherapeutic intervention in cancer. ..
  36. Viruses and Autoimmunity ot the Central Nervous System
    ROBERT FUJINAMI; Fiscal Year: 2004
    ..Our model could provide an explanation why no single microbe has been identified as the MS agent but is likely to be a combination of infectious events. ..
  37. Hamster Model for AIDS Lymphomas
    JANET BUTEL; Fiscal Year: 2003
    ..In addition, this project may provide new insights into lymphomagenesis in general and may lead to the development of new diagnostic and therapeutic approaches to this malignancy. ..
  38. ARSENIC TRIOXIDE TREATMENT OF LYMPHOPROLIFERATIVE DISORD
    Samuel Waxman; Fiscal Year: 2003
    ..Should our laboratory study identify agents or schedules that enhance the response to As203, we will use them to appropriately modify the initial phase II pilot study. ..
  39. ANTILEUKEMIA ACTIVITY OF PERILLYL ALCOHOL
    Steven Clark; Fiscal Year: 2003
    ..abstract_text> ..
  40. TRAF Regulation and Receptor Interactions in TNFR Family Signals
    GAIL BISHOP; Fiscal Year: 2009
    ..To explore the role of TRAF5 in B cell activation. ..
  41. Institute of Human Virology Annual Meeting 2002-2004
    Robert Gallo; Fiscal Year: 2002
    ..abstract_text> ..
  42. MECHANISM OF HPV E2 MEDIATED CELLULAR GROWTH SUPPRESSION
    Peter Howley; Fiscal Year: 2002
    ..In this grant application, we propose to examine the mechanisms by which E2 causes cellular growth suppression. ..
  43. BIOCHEMICAL MECHANISM OF TRANSACTIVATION IN HTLV 1
    Chou Zen Giam; Fiscal Year: 2002
    ....
  44. JSRV AND OVINE PULMONARY CARCINOMA
    James DeMartini; Fiscal Year: 2001
    ..All of these techniques have been done by the investigators involved. Similar studies, in some cases without the advantage of the newer techniques, have been used with success in other studies of retroviral-associated neoplasia. ..
  45. Immunologic Factors In Progressive Autoimmune Disease
    ROBERT FUJINAMI; Fiscal Year: 2005
    ..These new models could help explain the transition from RR disease to progressive disease often observed in MS patients. ..
  46. Oncogenesis In Retrovirus-Induced Lung Cancer
    Massimo Palmarini; Fiscal Year: 2005
    ..The completion of these experiments will clarify the molecular mechanisms of JSRV-induced pulmonary carcinogenesis and might furnish an intellectual framework to unravel the pathogenesis of some forms of human lung cancer. ..
  47. Interferon Regulatory Factor 7 and NPC
    Luwen Zhang; Fiscal Year: 2006
    ..This study would lead to a better understanding of how LMP-1 and IRF-7 interact to participate in viral pathogenesis, latency, and transformation. ..
  48. FORMAL METHODS APPLIED TO BIOLOGICAL SIGNALING NETWORKS
    Keith Laderoute; Fiscal Year: 2006
    ..abstract_text> ..
  49. A NOVEL VECTOR FOR VACCINATION AGAINST HEPETITIS C VIRUS
    Nikolaus Osterrieder; Fiscal Year: 2006
    ..The tests will include ELISPOT and CTL assays in the context of a human class I allele using HLA-A2.1 transgenic mice. ..
  50. MOLECULAR PATHOGENESIS OF SPINAL MUSCULAR ATROPHY
    Elliot Androphy; Fiscal Year: 2004
    ..Furthermore, SMN point mutants from SMA patients show defective oligomerization proportional to their disease severity. These studies have defined the genetic and biochemical basis for development of SMA. ..
  51. Papillomavirus Inhibitors for AIDS-related Malignancies
    Elliot Androphy; Fiscal Year: 2005
    ..The optimal cellular delivery system for the best inhibitors will be defined. The overall goal is to achieve high potency in cell-based models for eventual testing in animals and in human clinical trials. ..
  52. VZV BACs: New Tools for Pathogenesis Research
    Nikolaus Osterrieder; Fiscal Year: 2005
    ..B-scid/beige mice, and infected MeWo or MeWo-9 cells will be used to inoculate the grafts. Virus replication in the implants will be examined by virus titrations, real-time PCR, histopathology and immunohistochemistry. ..
  53. Genetic system for thesus monkey rhadinovirus (RRV)
    Blossom Damania; Fiscal Year: 2005
    ..In addition, it would also help us shed light on the lifecycle and pathogenesis of the gamma herpesvirus family, in general. ..
  54. Molecular Epidemiology of N. gonorrhoeae
    Raphael Viscidi; Fiscal Year: 2006
    ..gonorrhea in the core. The third aim is to determine whether gender, age, or disseminated versus local infection influences the population genetic structure of N. gonorrhea. ..
  55. SV40 T Antigen Role in Virus Growth and Transformation
    James M Pipas; Fiscal Year: 2010
    ..3. Distinguish the relative roles of the T antigen HR domain and the viral miRNAs in SV40 infection. 4. Determine whether T antigen autoregulation contribute to CTL evasion? ..
  56. IBD--MUCOSA-SPECIFIC REGULATION OF IFN-GAMMA PRODUCTION
    Stephan Targan; Fiscal Year: 2005
    ..abstract_text> ..
  57. HEPADNAVIRUS INFECTIONS AND LIVER CANCER
    William Mason; Fiscal Year: 2009
    ..abstract_text> ..
  58. LSRII Four Laser Analytical Flow Cytometer
    David Thorley Lawson; Fiscal Year: 2006
    ..This renders the acquisition of a new LSR II essential, if we are to meet the flow cytometry needs, both in time and available technology, for the community of NIH funded researchers at TUSM and T-NEMC. [unreadable] [unreadable]..
  59. Molecular Functions of the Adenovirus E1A Oncogene
    Maurice Green; Fiscal Year: 2006
    ..The functional consequences of interaction between E1A and specific cellular promoters will be established by kinetic studies of the gene specific mRNA and protein products. ..
  60. Mechanism of HTLV-1 Leukemogenesis
    Chou Zen Giam; Fiscal Year: 2006
    ..Aim 2: Tax, PP2A, and cell cycle control. Aim 3: Use of Saccharomyces cerevisiae as a model to study cell cycle abnormalities induced by Tax. ..
  61. ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATES
    Raphael Viscidi; Fiscal Year: 2001
    ..of incident HPV infection and/or disease? (6) In HIV seropositive women, is the extent of immunodeficiency, as measured by CD4+ cell counts, inversely correlated with the degree of protection provided by pre-existing anti-VLP antibodies? ..
  62. The Roles of IRF-3 in the Cellular Response to Viral Infection
    Peter Howley; Fiscal Year: 2007
    ..We will explore this pathway and examine the mechanisms by which some viruses inactivate this pathway for the replication of the virus and the survival of the infected cell. ..
  63. High Throughput Screen for Compounds to Treat Papillomavirus Induced Cancers
    Elliot Androphy; Fiscal Year: 2007
    ..Success would impact the health of millions of women and men afflicted with HPV infections and associated malignancies. [unreadable] [unreadable] [unreadable]..