celiac disease

Summary

Summary: A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.

Top Publications

  1. ncbi European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease
    S Husby
    Hans Christian Andersen Children s Hospital at Odense University Hospital
    J Pediatr Gastroenterol Nutr 54:136-60. 2012
  2. pmc The Oslo definitions for coeliac disease and related terms
    Jonas F Ludvigsson
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Gut 62:43-52. 2013
  3. pmc Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
    Gosia Trynka
    Genetics Department, University Medical Center and University of Groningen, The Netherlands
    Nat Genet 43:1193-201. 2011
  4. pmc Multiple common variants for celiac disease influencing immune gene expression
    Patrick C A Dubois
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Nat Genet 42:295-302. 2010
  5. ncbi Celiac disease
    Peter H R Green
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    N Engl J Med 357:1731-43. 2007
  6. pmc ACG clinical guidelines: diagnosis and management of celiac disease
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Gastroenterol 108:656-76; quiz 677. 2013
  7. ncbi Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study
    Alessio Fasano
    Center for Celiac Research, University of Maryland School of Medicine, 22 S Greene St, N5W70, PO Box 140, Baltimore, MD 21201 1595, USA
    Arch Intern Med 163:286-92. 2003
  8. pmc Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
    R W Depaolo
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Nature 471:220-4. 2011
  9. pmc Spectrum of gluten-related disorders: consensus on new nomenclature and classification
    Anna Sapone
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Med 10:13. 2012
  10. ncbi Celiac disease: from pathogenesis to novel therapies
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 137:1912-33. 2009

Detail Information

Publications340 found, 100 shown here

  1. ncbi European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease
    S Husby
    Hans Christian Andersen Children s Hospital at Odense University Hospital
    J Pediatr Gastroenterol Nutr 54:136-60. 2012
    ....
  2. pmc The Oslo definitions for coeliac disease and related terms
    Jonas F Ludvigsson
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Gut 62:43-52. 2013
    ..The literature suggests a lack of consensus on the use of terms related to coeliac disease (CD) and gluten...
  3. pmc Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
    Gosia Trynka
    Genetics Department, University Medical Center and University of Groningen, The Netherlands
    Nat Genet 43:1193-201. 2011
    ..genotyped 183 non-HLA risk loci previously associated with immune-mediated diseases in 12,041 individuals with celiac disease (cases) and 12,228 controls...
  4. pmc Multiple common variants for celiac disease influencing immune gene expression
    Patrick C A Dubois
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Nat Genet 42:295-302. 2010
    We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects...
  5. ncbi Celiac disease
    Peter H R Green
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    N Engl J Med 357:1731-43. 2007
  6. pmc ACG clinical guidelines: diagnosis and management of celiac disease
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Gastroenterol 108:656-76; quiz 677. 2013
    This guideline presents recommendations for the diagnosis and management of patients with celiac disease. Celiac disease is an immune-based reaction to dietary gluten (storage protein for wheat, barley, and rye) that primarily affects the ..
  7. ncbi Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study
    Alessio Fasano
    Center for Celiac Research, University of Maryland School of Medicine, 22 S Greene St, N5W70, PO Box 140, Baltimore, MD 21201 1595, USA
    Arch Intern Med 163:286-92. 2003
    b>Celiac disease (CD) is an immune-mediated enteropathic condition triggered in genetically susceptible individuals by the ingestion of gluten...
  8. pmc Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
    R W Depaolo
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Nature 471:220-4. 2011
    ..Altogether, these findings reveal an unexpected role for retinoic acid and IL-15 in the abrogation of tolerance to dietary antigens...
  9. pmc Spectrum of gluten-related disorders: consensus on new nomenclature and classification
    Anna Sapone
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Med 10:13. 2012
    A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals...
  10. ncbi Celiac disease: from pathogenesis to novel therapies
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 137:1912-33. 2009
    b>Celiac disease has become one of the best-understood HLA-linked disorders...
  11. ncbi Increasing prevalence of coeliac disease over time
    S Lohi
    Paediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Aliment Pharmacol Ther 26:1217-25. 2007
    ..The number of coeliac disease diagnoses has increased in the recent past and according to screening studies, the total prevalence of the disorder is around 1%...
  12. pmc Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease
    Isabel Comino
    Departamento de Microbiologia y Parasitologia, Facultad de Farmacia, Universidad de Sevilla, C Profesor García González, Spain
    Gut 60:915-22. 2011
    ..The stated aim of this study is to test whether this observed reactivity could be related to the potential toxicity of oats for patients with CD...
  13. ncbi Evidence of high sugar intake, and low fibre and mineral intake, in the gluten-free diet
    D Wild
    Academic Unit of Medicine, St James s University Hospital, Leeds LS97TF, UK
    Aliment Pharmacol Ther 32:573-81. 2010
    ..The only therapy for coeliac disease (CD) is a long-term gluten-free diet (GFD). Little is known about the detailed composition of such a diet...
  14. pmc Delay to celiac disease diagnosis and its implications for health-related quality of life
    Fredrik Norström
    Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umea University, Umea, Sweden
    BMC Gastroenterol 11:118. 2011
    To determine how the delay in diagnosing celiac disease (CD) has developed during recent decades and how this affects the burden of disease in terms of health-related quality of life (HRQoL), and also to consider differences with respect ..
  15. pmc From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases
    Vinod Kumar
    Department of Genetics, University Medical Hospital Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Semin Immunopathol 34:567-80. 2012
    b>Celiac disease is characterized by a chronic inflammatory reaction in the intestine and is triggered by gluten, a constituent derived from grains which is present in the common daily diet in the Western world...
  16. ncbi Coeliac disease
    Antonio Di Sabatino
    First Department of Medicine, Centro per lo Studio e la Cura della Malattia Celiaca, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Lancet 373:1480-93. 2009
    ..In this Seminar we critically reassess the clinical and diagnostic aspects of this disease and new perspectives in its pathogenesis and treatment...
  17. ncbi Intraepithelial lymphocytes in celiac disease immunopathology
    Valérie Abadie
    Sainte Justine Hospital Research Centre, Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, Montreal, QC, H3T 1C5, Canada
    Semin Immunopathol 34:551-66. 2012
    b>Celiac disease is a T cell-mediated immune disorder induced by dietary gluten that is characterized by the development of an inflammatory anti-gluten CD4 T cell response, anti-gluten antibodies, and autoantibodies against tissue ..
  18. ncbi The prevalence of celiac disease in the United States
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 107:1538-44; quiz 1537, 1545. 2012
    The prevalence of celiac disease (CD) in the United States is unknown. We sought to estimate CD prevalence nationwide by using a nationally representative sample.
  19. ncbi Integration of genetic and immunological insights into a model of celiac disease pathogenesis
    Valérie Abadie
    Department of Medicine, University of Chicago, Illinois 60637, USA
    Annu Rev Immunol 29:493-525. 2011
    b>Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically susceptible individuals by exposure to cereal gluten proteins...
  20. ncbi The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review
    Catherine Dube
    Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Ontario, Canada
    Gastroenterology 128:S57-67. 2005
    Until recently, celiac disease (CD) was felt to be a rare disease in the United States. The aim of this study was to conduct a systematic review of the prevalence of CD in general Western populations and in populations at high risk for CD...
  21. pmc Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
    Alexandra Zhernakova
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Genet 7:e1002004. 2011
    Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored...
  22. ncbi Tissue-mediated control of immunopathology in coeliac disease
    Bana Jabri
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Immunol 9:858-70. 2009
    ....
  23. ncbi Gluten-free diet and quality of life in patients with screen-detected celiac disease
    Kirsi Mustalahti
    Department of Pediatrics, Tampere University Hospital, Finland
    Eff Clin Pract 5:105-13. 2002
    Since the advent of serologic testing for celiac disease, most persons who receive a diagnosis of celiac disease have few or no symptoms...
  24. pmc Alterations in intestinal permeability
    M C Arrieta
    Department of Medicine, University of Alberta, Alberta, Canada
    Gut 55:1512-20. 2006
  25. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin...
  26. ncbi The prevalence of celiac disease in Europe: results of a centralized, international mass screening project
    Kirsi Mustalahti
    Paediatric Research Centre, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Ann Med 42:587-95. 2010
    Although the prevalence of celiac disease (CD) has been extensively investigated in recent years, an accurate estimate of CD frequency in the European population is still lacking...
  27. ncbi Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Ivor D Hill
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 40:1-19. 2005
    b>Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals...
  28. pmc Increasing incidence of celiac disease in a North American population
    Jonas F Ludvigsson
    Division of Gastroenterology and Hepatology, Departments of Medicine and Immunology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Am J Gastroenterol 108:818-24. 2013
    The prevalence of celiac disease (CD) varies greatly, potentially because of incomplete ascertainment of cases and small study samples with limited statistical power. Previous reports indicate that the incidence of CD is increasing...
  29. ncbi Celiac disease revealed in 3% of Swedish 12-year-olds born during an epidemic
    Anna Myléus
    Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences, Umea University, Umea, Sweden
    J Pediatr Gastroenterol Nutr 49:170-6. 2009
    Sweden experienced a marked epidemic of celiac disease between 1984 and 1996 in children younger than 2 years of age, partly explained by changes in infant feeding...
  30. ncbi The incidence and clinical spectrum of refractory celiac disease in a north american referral center
    Bakht Roshan
    Department of Gastroenterology, Celiac Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Gastroenterol 106:923-8. 2011
    Refractory celiac disease (RCD) is one of the most serious causes of persistent symptoms in patients with celiac disease (CD)...
  31. ncbi Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet
    T A Kabbani
    Department of Medicine and Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Aliment Pharmacol Ther 35:723-9. 2012
    ..Coeliac disease is increasingly diagnosed and weight changes are common after adoption of a gluten-free diet (GFD), however data on body mass index (BMI) changes are limited...
  32. pmc Gliadin-mediated proliferation and innate immune activation in celiac disease are due to alterations in vesicular trafficking
    M Vittoria Barone
    Department of Pediatrics, European Laboratory for the Investigation of Food Induced Diseases, University of Naples Federico II, Naples, Italy
    PLoS ONE 6:e17039. 2011
    Damage to intestinal mucosa in celiac disease (CD) is mediated both by inflammation due to adaptive and innate immune responses, with IL-15 as a major mediator of the innate immune response, and by proliferation of crypt enterocytes as an ..
  33. ncbi HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22
    M Bodd
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Mucosal Immunol 3:594-601. 2010
    ..of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4(+) T cells of celiac disease patients, either cultured from small intestinal biopsies or isolated from peripheral blood after an oral ..
  34. ncbi Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease
    Luigi Maiuri
    Institute of Child Health, University College London, London, UK
    Lancet 362:30-7. 2003
    ..We investigated whether gliadin, a protein present in wheat flour, could activate an innate as well as an adaptive immune response in patients with coeliac disease...
  35. pmc Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis
    Miklós Sárdy
    Department of Dermato Venereology, Semmelweis University, H 1085 Budapest, Maria u 41, Hungary
    J Exp Med 195:747-57. 2002
    Gluten sensitivity typically presents as celiac disease, a common chronic small intestinal disorder...
  36. ncbi Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease
    Jurgen Glas
    Department of Medicine II, Grosshadern, Ludwig Maximilians University, Munich, Germany
    Am J Gastroenterol 104:1737-44. 2009
    ..polymorphisms (SNPs) in the chromosome 4q27 region containing IL2 and IL21 are associated with celiac disease. Given the increased prevalence of inflammatory bowel disease (IBD) among celiac disease patients, we ..
  37. ncbi Changes of body mass index in celiac children on a gluten-free diet
    P Brambilla
    Italian Federation of Family Pediatricians FIMP, Department of Continuing Medical Education, Area Lombardia, Italy
    Nutr Metab Cardiovasc Dis 23:177-82. 2013
    Studies of adults and children with celiac disease (CD) performed mostly in tertiary care centers have reported an increased risk of overweight during gluten-free diet (GFD)...
  38. pmc Celiac disease: prevalence, diagnosis, pathogenesis and treatment
    Naiyana Gujral
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada
    World J Gastroenterol 18:6036-59. 2012
    b>Celiac disease (CD) is one of the most common diseases, resulting from both environmental (gluten) and genetic factors [human leukocyte antigen (HLA) and non-HLA genes]. The prevalence of CD has been estimated to approximate 0...
  39. ncbi The diagnostic accuracy of serologic tests for celiac disease: a systematic review
    Alaa Rostom
    Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Canada
    Gastroenterology 128:S38-46. 2005
    Clinicians are increasingly utilizing noninvasive serologic tests for the diagnosis and screening of celiac disease (CD)...
  40. ncbi Systematic review: tolerable amount of gluten for people with coeliac disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:1044-52. 2008
    ..The threshold amount of gluten in 'gluten-free' products that can be tolerated by people with coeliac disease is unclear...
  41. ncbi Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet
    A Lanzini
    Gastroenterology Unit, University and Spedali Civili of Brescia, Brescia, Italy
    Aliment Pharmacol Ther 29:1299-308. 2009
    ..Expected benefits of gluten-free diet (GFD) in coeliac patients include healing of small intestinal mucosa, but it remains unclear to what extent this benefit is achieved in adults...
  42. pmc Molecular and immunological characterization of gluten proteins isolated from oat cultivars that differ in toxicity for celiac disease
    Ana Real
    Departamento de Microbiologia y Parasitologia, Universidad de Sevilla, Sevilla, Spain
    PLoS ONE 7:e48365. 2012
    A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease (CD)...
  43. ncbi Celiac disease: an immunological jigsaw
    Bertrand Meresse
    INSERM, U989, Universite Paris Descartes, Paris Sorbonne Centre, Institut Imagine, Paris, France
    Immunity 36:907-19. 2012
    b>Celiac disease (CD) is a chronic enteropathy induced by dietary gluten in genetically predisposed people...
  44. ncbi Body mass index in celiac disease: beneficial effect of a gluten-free diet
    Jianfeng Cheng
    Department of Medicine, Sound Shore Medical Center of Westchester, New Rochelle, NY, USA
    J Clin Gastroenterol 44:267-71. 2010
    There is concern about celiac disease patients being overweight and gaining more weight while on a gluten-free diet (GFD).
  45. ncbi New clues in celiac disease epidemiology, pathogenesis, clinical manifestations, and treatment
    Elena Lionetti
    Department of Pediatrics, University of Catania, Catania, Italy
    Int Rev Immunol 30:219-31. 2011
    b>Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. It is one of the most common lifelong disorders on a worldwide basis...
  46. ncbi A genetic perspective on coeliac disease
    Gosia Trynka
    Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
    Trends Mol Med 16:537-50. 2010
    ....
  47. ncbi Psoriasis in a nationwide cohort study of patients with celiac disease
    Jonas F Ludvigsson
    Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
    J Invest Dermatol 131:2010-6. 2011
    Earlier studies on the association between celiac disease (CD) and psoriasis show contradictory results. The purpose of this study was to assess the risk of psoriasis in patients with biopsy-verified CD...
  48. ncbi Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease
    Michael Schumann
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charite Berlin, Berlin, Germany
    Gut 61:220-8. 2012
    ..Epithelial barrier defects are well known in coeliac disease, but the mechanisms are only poorly defined. It is unclear, whether barrier disturbance reflects upregulated epithelial transcytosis or paracellular leakage...
  49. ncbi Characterization of gliadin-specific Th17 cells from the mucosa of celiac disease patients
    Silvia Fernandez
    Unidad de Inmunologia, Facultad de Medicina, Universidad de Cordoba, Cordoba, Spain
    Am J Gastroenterol 106:528-38. 2011
    b>Celiac disease (CD) is a disorder characterized by a deregulated immune response to ingested wheat gluten and related cereal proteins in susceptible individuals...
  50. ncbi Coeliac disease, autoimmune diseases and gluten exposure
    Mervi Viljamaa
    Department of Internal Medicine, Tampere University Hospital, Finland
    Scand J Gastroenterol 40:437-43. 2005
    ..The aim here was to investigate the occurrence of autoimmune disorders in relation to gluten intake in coeliac patients in a well-defined area...
  51. ncbi Gluten-free diet and autoimmune thyroiditis in patients with celiac disease. A prospective controlled study
    Saara Metso
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 47:43-8. 2012
    ..dietary treatment with a gluten-free diet might slow down the progression of associated autoimmune diseases in celiac disease, but the data are contradictory...
  52. pmc Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3
    Karen M Lammers
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 135:194-204.e3. 2008
    b>Celiac disease is an immune-mediated enteropathy triggered by gliadin, a component of the grain protein gluten...
  53. pmc Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study
    Marjorie M Walker
    Department of Histopathology, Faculty of Medicine, St Mary s Campus, Imperial College London, London, United Kingdom
    Gastroenterology 139:112-9. 2010
    Although serologic analysis is used in diagnosis of celiac disease, histopathology is considered most reliable...
  54. ncbi Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial
    Jessica R Biesiekierski
    Monash University Department of Medicine and Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    Am J Gastroenterol 106:508-14; quiz 515. 2011
    ..increased prescription of a gluten-free diet for gastrointestinal symptoms in individuals who do not have celiac disease, there is minimal evidence that suggests that gluten is a trigger...
  55. ncbi HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease
    Kati Karell
    Department of Tissue Typing, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Hum Immunol 64:469-77. 2003
    Genetic susceptibility to celiac disease is strongly associated with HLA-DQA1*05-DQB1*02 (DQ2) and HLA-DQA1*03-DQB1*0302 (DQ8)...
  56. pmc A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease
    Eleonora A M Festen
    Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    PLoS Genet 7:e1001283. 2011
    Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis...
  57. ncbi Molecular basis of celiac disease
    L M Sollid
    Institute of Immunology, Rikshospitalet, University of Oslo, Norway
    Annu Rev Immunol 18:53-81. 2000
    b>Celiac disease (CD) is an intestinal disorder with multifactorial etiology. HLA and non-HLA genes together with gluten and possibly additional environmental factors are involved in disease development...
  58. pmc Increased prevalence and mortality in undiagnosed celiac disease
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:88-93. 2009
    The historical prevalence and long-term outcome of undiagnosed celiac disease (CD) are unknown. We investigated the long-term outcome of undiagnosed CD and whether the prevalence of undiagnosed CD has changed during the past 50 years.
  59. ncbi Breast-feeding protects against celiac disease
    Anneli Ivarsson
    Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden
    Am J Clin Nutr 75:914-21. 2002
    b>Celiac disease, or permanent gluten-sensitive enteropathy, is an immunologic disease strictly dependent on exposure to wheat gluten or related proteins in rye and barley.
  60. ncbi Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling
    G Trynka
    Genetics Department, University Medical Centre, University of Groningen, Groningen, The Netherlands
    Gut 58:1078-83. 2009
    ..To identify more coeliac disease loci, we selected 458 single nucleotide polymorphisms (SNPs) that showed more modest association in the GWAS for genotyping and analysis in four independent cohorts...
  61. ncbi Prevalence of Celiac disease among children in Finland
    Markku Maki
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    N Engl J Med 348:2517-24. 2003
    Wheat, rye, and barley proteins induce celiac disease, an autoimmune type of gastrointestinal disorder, in genetically susceptible persons...
  62. ncbi A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease
    Carlo Catassi
    Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Clin Nutr 85:160-6. 2007
    Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients.
  63. pmc HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing
    Francesca Megiorni
    Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324 Rome, Italy
    J Biomed Sci 19:88. 2012
    b>Celiac disease (CD) is a multifactorial disorder with an estimated prevalence in Europe and USA of 1:100 and a female:male ratio of approximately 2:1...
  64. ncbi Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
    Sandro Drago
    Mucosal Biology Research Center, Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Scand J Gastroenterol 41:408-19. 2006
    ..We investigated whether gliadin has any immediate effect on zonulin release and signaling...
  65. ncbi Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the Continuous National Health and Nutrition Examination Survey 2009-2010
    Daniel V Digiacomo
    Department of Medicine, Celiac Disease Center at Columbia University, Columbia University, New York, NY 10032, USA
    Scand J Gastroenterol 48:921-5. 2013
    ..Clinical inference suggests the prevalence of non-celiac gluten sensitivity is substantially higher than that of celiac disease in the USA. Unfortunately, there are currently no data supporting these claims...
  66. pmc Oats to children with newly diagnosed coeliac disease: a randomised double blind study
    L Hogberg
    Department of Paediatrics, Norrköping Hospital, Sweden
    Gut 53:649-54. 2004
    ..Recent studies, mainly in adults, have shown that oats are non-toxic to CD patients. In children, only open studies comprising a small number of patients have been performed...
  67. ncbi Epidemic of coeliac disease in Swedish children
    A Ivarsson
    Department of Clinical Science, Umea University, Sweden
    Acta Paediatr 89:165-71. 2000
    ..e. amount of gluten given, age at introduction of gluten, and whether breastfeeding was ongoing or not when gluten was introduced. Other factor(s) may also have contributed, and the search for these should be intensified...
  68. ncbi Prevalence of childhood celiac disease and changes in infant feeding
    Anneli Ivarsson
    Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umea University, Umea, Sweden
    Pediatrics 131:e687-94. 2013
    Between 1984 and 1996, Sweden experienced an "epidemic" of clinical celiac disease in children <2 years of age, attributed partly to changes in infant feeding...
  69. pmc Pregnancy outcome and risk of celiac disease in offspring: a nationwide case-control study
    Karl Mårild
    Astrid Lindgren Children s Hospital, Solna, Sweden
    Gastroenterology 142:39-45.e3. 2012
    Studies on pregnancy characteristics and mode of delivery and risk of later celiac disease in offspring are inconsistent...
  70. ncbi High fat consumption in children with celiac disease
    P Ferrara
    Department of Pediatric Sciences, Universita Cattolica Sacro Cuore, Rome, Italy
    Acta Gastroenterol Belg 72:296-300. 2009
    The purpose of this study was to estimate the caloric intake and fat consumption in children with celiac disease (CD) following a gluten-free diet (GFD).
  71. ncbi High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
    Roberto Di Niro
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Nat Med 18:441-5. 2012
    b>Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous antigen gluten in individuals who express human leukocyte antigen HLA-DQ2 or ..
  72. pmc Factors that influence adherence to a gluten-free diet in adults with celiac disease
    Daniel A Leffler
    Department of Gastroenterology, The Celiac Center, Dana 501, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Dig Dis Sci 53:1573-81. 2008
    The only treatment for celiac disease is lifelong adherence to a gluten-free diet, yet adherence is limited and factors influencing adherence are poorly understood...
  73. ncbi The adaptive immune response in celiac disease
    Shuo Wang Qiao
    Department of Immunology and Centre for Immune Regulation, University of Oslo, Oslo University Hospital Rikshospitalet, 0027, Oslo, Norway
    Semin Immunopathol 34:523-40. 2012
    ..as type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, fundamental aspects of the pathogenesis in celiac disease are relatively well understood...
  74. pmc A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge
    Daniel A Leffler
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Gastroenterol 107:1554-62. 2012
    In patients with celiac disease, enteropathy is caused by the entry of gluten peptides into the lamina propria of the intestine, in which their immunogenicity is potentiated by tissue transglutaminase (tTG) and T-helper type 1-mediated ..
  75. ncbi Celiac disease: antibody recognition against native and selectively deamidated gliadin peptides
    M Aleanzi
    Cátedra de Bioquímica Básica de Macromoléculas, INTEBIO, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Pje el Pozo CC 242, 3000 Santa Fe, Argentina
    Clin Chem 47:2023-8. 2001
    ..residues by tissue transglutaminase (tTG) turns gliadin peptides into stronger activators of T cells from celiac disease (CD) patients...
  76. ncbi Fracture risk in patients with celiac Disease, Crohn's disease, and ulcerative colitis: a nationwide follow-up study of 16,416 patients in Denmark
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Am J Epidemiol 156:1-10. 2002
    The authors studied fracture risk among 16,416 Danish patients with bowel disease. All patients diagnosed with celiac disease (n = 1,021), Crohn's disease (n = 7,072), or ulcerative colitis (n = 8,323) in Denmark between January 1, 1983, ..
  77. pmc The incidence and risk of celiac disease in a healthy US adult population
    Mark S Riddle
    Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Am J Gastroenterol 107:1248-55. 2012
    b>Celiac disease (CD) is an increasingly common disease that may affect as many as 1% of the North American population. Recent population-based data suggest a substantial increase in the prevalence of CD over the last several decades...
  78. ncbi Risk of thyroid disease in individuals with celiac disease
    Peter Elfström
    Department of Pediatrics, Orebro University Hospital, SE 701 85 Orebro, Sweden
    J Clin Endocrinol Metab 93:3915-21. 2008
    It has been suggested that celiac disease is associated with thyroid disease. Earlier studies, however, have been predominately cross-sectional and have often lacked controls. There is hence a need for further research...
  79. pmc PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage
    Maria Paola Simula
    Experimental and Clinical Pharmacology Unit, CRO Centro diRiferimento Oncologico, IRCCS National Cancer Institute, Aviano PN, Italy
    Mol Med 16:199-209. 2010
    b>Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of wheat gliadin and related proteins in genetically predisposed individuals...
  80. pmc Influence of environmental and genetic factors linked to celiac disease risk on infant gut colonization by Bacteroides species
    Ester Sanchez
    Ecofisiología Microbiana y Nutrición, Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Avda Agustín Escardino 7, 46980 Paterna, Valencia, Spain
    Appl Environ Microbiol 77:5316-23. 2011
    b>Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors whose interaction might influence disease risk...
  81. ncbi TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin
    Ainara Castellanos-Rubio
    Endocrinology, Diabetes and Nutrition Research Group, Immunogenetics Laboratory, Hospital de Cruces, Bizkaia, Spain
    Autoimmunity 42:69-73. 2009
    b>Celiac disease (CD) is an immunological disorder caused by intolerance to ingested gliadin and other cereal prolamins that has been included in the T(H)1-dominated group of diseases, where IL-12 induced IFNgamma is the major ..
  82. ncbi Unraveling the ties between celiac disease and intestinal microbiota
    Yolanda Sanz
    Institute of Agrochemistry and Food Technology, Spanish National Research Council, Valencia, Spain
    Int Rev Immunol 30:207-18. 2011
    b>Celiac disease is a multifactorial disorder that involves interactions between genetic and environmental factors...
  83. pmc Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study
    Giada De Palma
    Instituto de Agroquimica y Tecnologia de Alimentos, Consejo Superior de Investigaciones Científicas IATA CSIC, Valencia, Spain
    PLoS ONE 7:e30791. 2012
    ....
  84. pmc Newly identified genetic risk variants for celiac disease related to the immune response
    Karen A Hunt
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Nat Genet 40:395-402. 2008
    Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region...
  85. ncbi Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase
    Ingrid Dahlbom
    Department of Women s and Children s Health Paediatrics, Uppsala University, Uppsala, Sweden
    J Pediatr Gastroenterol Nutr 50:140-6. 2010
    ..We analysed whether the quantification of autoantibodies against tissue transglutaminase could be used to predict mucosal destruction and disease severity in patients with gluten sensitivity...
  86. ncbi Structural basis for gluten intolerance in celiac sprue
    Lu Shan
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305 5025, USA
    Science 297:2275-9. 2002
    ..The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue...
  87. ncbi Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease
    Jill M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    JAMA 293:2343-51. 2005
    While gluten ingestion is responsible for the signs and symptoms of celiac disease, it is not known what factors are associated with initial appearance of the disease.
  88. ncbi Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal
    Antonella Meloni
    Pediatric Clinic II, Microcitemico Hospital ASL 8, Department of Biological Sciences and Biotechnology, University of Cagliari, Sardinia, Italy
    J Pediatr 155:51-5, 55.e1. 2009
    To study the prevalence of autoimmune thyroiditis (AT) in Sardinian children with celiac disease (CD) and the effects of a gluten-free diet (GFD) on thyroid function.
  89. ncbi Celiac disease presenting as autism
    Stephen J Genuis
    University of Alberta, Alberta, Canada
    J Child Neurol 25:114-9. 2010
    ..After initial investigation suggested underlying celiac disease and varied nutrient deficiencies, a gluten-free diet was instituted along with dietary and supplemental ..
  90. pmc Celiac disease: how complicated can it get?
    Jennifer May Ling Tjon
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, RC Leiden, The Netherlands
    Immunogenetics 62:641-51. 2010
    In the small intestine of celiac disease patients, dietary wheat gluten and similar proteins in barley and rye trigger an inflammatory response...
  91. ncbi The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease
    Alessandra Pontillo
    Medical Genetic Service, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    Am J Gastroenterol 106:539-44. 2011
    b>Celiac disease (CD) is a multifactorial common disorder with several susceptibility loci. Variations in the NALP1/NLRP1 and NALP3/NLRP3 genes have been reported to confer risk for several autoimmune conditions...
  92. pmc Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
    Maria Carmen Collado
    Microbial Ecophysiology and Nutrition Group Institute of Agrochemistry and Food Technology, Spanish National Research Council CSIC, Burjassot, Valencia, Spain
    BMC Microbiol 8:232. 2008
    ..Samples (30 faecal samples and 8 biopsies) from a control age-matched group of children were also included for comparative purposes. Gut Bifidobacterium genus and species were analyzed by real-time PCR...
  93. pmc Celiac disease
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Departments of Medicine and Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Opin Gastroenterol 26:116-22. 2010
    To summarize recent advances in celiac disease published between August 2008 and July 2009.
  94. pmc Cutaneous manifestations in celiac disease
    L Abenavoli
    Institute of Internal Medicine, Catholic University, L go Gemelli 8, 00168 Rome, Italy
    World J Gastroenterol 12:843-52. 2006
    b>Celiac disease (CD) is an autoimmune gluten-dependent enteropathy characterized by atrophy of intestinal villi that improves after gluten-free diet (GFD)...
  95. ncbi Natural history of celiac disease autoimmunity in a USA cohort followed since 1974
    Carlo Catassi
    Center for Celiac Research and Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Ann Med 42:530-8. 2010
    The natural history and the possible changes of celiac disease (CD) prevalence over time are still unclear.
  96. ncbi Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease
    M C Collado
    Microbial Ecophysiology and Nutrition Group, Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Valencia, Spain
    J Clin Pathol 62:264-9. 2009
    ..To identify specific gut bacteria associated with coeliac disease (CD) at diagnosis and after treatment with a gluten-free diet (GFD) in a paediatric population...
  97. ncbi Current concepts of celiac disease pathogenesis
    D Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Erlangen, Germany
    Gastroenterology 119:234-42. 2000
    Our knowledge of celiac disease pathogenesis has recently made rapid progress...
  98. pmc Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection
    Alexandra Zhernakova
    Complex Genetics Section, Department of Medical Genetics, University Medical Centre Utrecht, P O Box 85060, 3508 AB Utrecht, The Netherlands
    Am J Hum Genet 86:970-7. 2010
    b>Celiac disease (CD) is an intolerance to dietary proteins of wheat, barley, and rye. CD may have substantial morbidity, yet it is quite common with a prevalence of 1%-2% in Western populations...
  99. ncbi Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum
    A Fasano
    Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, Hospital for Children, Baltimore, Maryland 21201, USA
    Gastroenterology 120:636-51. 2001
    b>Celiac disease (CD) is a syndrome characterized by damage of the small intestinal mucosa caused by the gliadin fraction of wheat gluten and similar alcohol-soluble proteins (prolamines) of barley and rye in genetically susceptible ..
  100. ncbi Genetic background of celiac disease and its clinical implications
    Victorien M Wolters
    Department of Pediatric Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Am J Gastroenterol 103:190-5. 2008
    b>Celiac disease (CD) is a complex genetic disorder with multiple contributing genes. Linkage studies have identified several genomic regions that probably contain CD susceptibility genes...
  101. ncbi Diet improves perception of health and well-being in symptomatic, but not asymptomatic, patients with celiac disease
    Anniina Ukkola
    Medical School, University of Tampere, Tampere, Finland
    Clin Gastroenterol Hepatol 9:118-23. 2011
    The benefits of serologic screening and early diagnosis of celiac disease in asymptomatic patients are not known...

Research Grants64

  1. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..in bacterial, viral and parasitic infections, ischemia-reperfusion injury, inflammatory bowel disease, celiac disease and colorectal cancer...
  2. Irritable bowel syndrome-diarrhea: the role of gluten intolerance and HLA-DQ2
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..The relationship of celiac disease and IBS is complex;while guidelines suggest screening for celiac disease in patients with FD or IBS with ..
  3. Zot, Zonulin, and Pathophysiology of Intestinal Tight Junctions
    Alessio Fasano; Fiscal Year: 2013
    ..that zonulin expression is increased in autoimmune disorders associated with gut barrier dysfunction, such as celiac disease and type 1 diabetes...
  4. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Celiac disease (CD, gluten-sensitive enteropathy, celiac sprue) is a common disease with significant morbidity if untreated...
  5. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2013
    ..In humans, gluten-sensitive enteropathy (GSE) is typically found in individuals genetically predisposed to celiac disease (CD), and in rhesus monkeys as well as in humans it can be induced by a gluten-containing diet...
  6. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2011
    ..of inflammation in autoimmune syndromes such as in the synovial tissue in rheumatoid arthritis, the bowel in celiac disease, or the lungs in sarcoidosis. However, almost nothing is nothing regarding the specificity of ?? T cells...
  7. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..with digestive diseases including Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), and celiac disease. IBS is a common disorder with altered motility, secretion, and visceral sensation within the intestine for ..
  8. Benaroya Research Institute/UCDHSC Autoimmune Cooperative Study Group
    George S Eisenbarth; Fiscal Year: 2011
    ..risk alleles (DR3/4-DQ8) and haplotype sharing with siblings, and defined related but unique risk factors for celiac disease. Faculty for the Cooperative Study Group has been recruited from the Departments of Immunology, Pediatrics, ..
  9. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2013
    ..variety of human autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and celiac disease. The IL-2Rb-deficient model used in some of these studies also has an important link to human autoimmunity...
  10. TILLING Wheat for Reduced Celiac Disease Causing Proteins
    CHARLES PAUL MOEHS; Fiscal Year: 2010
    b>Celiac disease is an autoimmune digestive disorder in which intestinal lesions develop in genetically susceptible individuals in response to the ingestion of specific cereal seed storage proteins...
  11. Novel Mucosa-homing Dendritic Cell: Development, Trafficking and Function
    Eugene C Butcher; Fiscal Year: 2013
    ..g. for HIV or rotavirus) and to control pathologic inflammation (e.g. in inflammatory bowel diseases or celiac disease).
  12. Identification of Alopecia Areata Biomarkers in Skin and Blood
    Angela M Christiano; Fiscal Year: 2012
    ..in AA unexpectedly revealed a number of risk loci shared by rheumatoid arthritis (RA), type 1 diabetes (T1D), celiac disease (CeD), SLE, MS and psoriasis (PS)...
  13. Molecular Mechanisms Linking HLA-DQ and Autoimmunity
    Luc Teyton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Insulin-dependent diabetes mellitus (IDDM) and celiac disease are two of the most common immune-mediated diseases in humans...
  14. 16th International Congress of Mucosal Immunology (ICMI 2013)
    Joanne L Viney; Fiscal Year: 2013
    ..cytokines, urogenital immunology, pulmonary immunology, inflammation, allergy, inflammatory bowel disease, celiac disease, lymphocyte homing, cytokines and chemokines, inflammation, mucosal antibodies, ocular and upper airway ..
  15. Small Molecules Targeting Allele Specific MHC Class II Presentation
    Aaron W Michels; Fiscal Year: 2013
    ..The human MHC class II molecules DQ8 and DQ2 are the major determinants of both type 1 diabetes and celiac disease with more than 99% of patients with celiac disease having DQ8 or DQ2 and more than 90% of patients with type 1 ..
  16. Effect of the PPAR Agonist Pioglitazone on Epidermal Barrier in Atopic Dermatitis
    LISA ANN BECK; Fiscal Year: 2012
    ..of other human diseases mediated in part by epithelial barrier defects including inflammatory bowel disease, celiac disease, sinusitis, food allergy and asthma...
  17. Genetic Architecture of Rheumatoid Arthritis in African-Americans
    MARIA IOANA DANILA; Fiscal Year: 2013
    ..and Asian populations through GWAS strategy in autoimmune diseases including RA, type 1 diabetes, lupus, celiac disease, autoimmune thyroid disease, inflammatory bowel disease, ankylosing spondylitis, psoriasis and other diseases...
  18. 3'alpha enhancer regulation by AhR and NF-kappaB/Rel proteins
    COURTNEY ELIZABETH WILLIAMS SULENTIC; Fiscal Year: 2011
    ..also been associated with specific human pathologies including Burkitt's lymphoma, IgA nephropathy and Celiac disease. Many of the toxic effects of TCDD and related chemicals have been attributed to changes in gene expression ..
  19. Gastro-intestinal microbes degrading dietary gluten
    EVA JOSEPHINE HELMERHORST; Fiscal Year: 2013
    ..Glutens elicit immunologic reactions and serious clinical conditions in patients suffering from celiac disease. The basis of this disease is an auto-immune disorder in which a host-anti-self response is triggered by ..
  20. Reduced gluten cereal grains
    CHARLES PAUL MOEHS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Celiac disease (CD) is the most common food sensitive enteropathy known, affecting approximately 1% of the population and its incidence appears to be on the rise...
  21. Web-based and Interactive Virtual Environments for Children with Food Allergies
    Josh S Spitalnick; Fiscal Year: 2013
    ..for children with other chronic conditions requiring self-management, such as asthma, diabetes, and celiac disease. The promise of commercial opportunity is significant in an era in which there is an increasingly widespread ..
  22. Role of transglutaminase 2 in celiac sprue
    Chaitan Khosla; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our broad goal is to understand the role of transglutaminase 2 (TG2) in celiac disease pathogenesis...
  23. Innate and adaptive immunity in celiac disease
    Bana Jabri; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Celiac disease is a complex intestinal inflammatory disorder with villous atrophy induced by dietary gluten in HLA-DQ2 or HLA-DQ8 individuals...
  24. Validation of Novel Peptide/Protein Markers for Diagnosis of Type 1 Diabetes
    Qibin Zhang; Fiscal Year: 2012
    ..of T1D;Aim 2, to establish the specificity of marker peptides using disease controls of type 2 diabetes, celiac disease and inflammatory bowel disease;Aim 3, to identify the protein isoforms of key marker peptides having potential ..
  25. A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATION
    DECLAN MCCOLE; Fiscal Year: 2013
    ..a crucial role in a number of chronic intestinal inflammatory conditions including Type 1 Diabetes (T1D), celiac disease, as well as Crohn's disease (CD) and ulcerative colitis (UC), collectively referred to as inflammatory ..
  26. The Environmental Triggers of Diabetes (TEDDY)
    Ake Lernmark; Fiscal Year: 2013
    ..exposures that may trigger or protect against the development of islet autoimmunity and T1D as well as celiac disease, a common co-morbidity to T1D...
  27. Analysis of TLR4-dependent Innate Immune Responses induced by Dietary Glutens
    KRISTINA MICHELLE HARRIS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The quality of life for over 2 million Americans with celiac disease (CD) is significantly compromised because the only treatment is strict compliance to a gluten-free diet...
  28. gd IEL migration and epithelial interactions in intestinal disease
    KAREN LEIGH EDELBLUM; Fiscal Year: 2013
    ..to identify epithelial/immune cell interactions and determine the relevance of these interactions to IBD and celiac disease. The proposed research and career development plan, along with my mentors, advisory committee and the ..
  29. Oral microbial enzymes for the treatment of celiac disease
    EVA JOSEPHINE HELMERHORST; Fiscal Year: 2013
    ..The applicant's studies are focusing on a novel domain of gastro-intestinal enzymology related to celiac disease. Celiac disease is an auto-immune disorder in which a host anti-self response is triggered by gluten-derived ..
  30. Otubain 1 as a novel regulator of IL-15 signaling in CD8+ T cells
    ALBERT CHUH KAI LEE; Fiscal Year: 2013
    ..implicated in the pathogenesis of the intestinal inflammatory diseases, inflammatory bowel disease (IBD) and celiac disease. IL- 15 levels are elevated in both diseases and can correlate with disease severity in celiac disease...
  31. Regulation of osteoblast maturation by transglutaminases
    Maria Nurminskaya; Fiscal Year: 2010
    ..Further, the presence of circulating autoantibodies against TG2 in diabetes and celiac disease correlates with short stature and osteopenia, implicating involvement of transglutaminases in both bone ..
  32. Non-invasive markers of celiac disease activity during gluten challenge
    DANIEL ALEXANDER LEFFLER; Fiscal Year: 2013
    ..Drs. Ciaran P. Kelly and Detlef Schuppan, both acknowledged experts in celiac disease, will serve as mentors. A mentoring committee including Drs...
  33. Mechanisms and pathways of trans-tight junction conductance
    Christopher Weber; Fiscal Year: 2013
    ..and dysfunction, which may provide better therapeutic approaches for intestinal disorders such as IBD, celiac disease, and infectious colitis...
  34. Characterization of Innate immune receptors
    Detlef Schuppan; Fiscal Year: 2009
    b>Celiac disease (Cd) is a T cell mediated disease of the small intestine. It is triggered by dietary gluten proteins from cereals and affects 1 in 130 US citizens...
  35. Microbial Regulation of Macromolecule Absorption in the Zebrafish Intestine
    Jordan L Cocchiaro; Fiscal Year: 2012
    ..transcellular macromolecule transport ("ETMT") is associated with inflammatory bowel diseases (IBD), celiac disease, and food allergies...
  36. Genetic and Environmental Causes of Celiac Disease.
    Marian J Rewers; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Celiac disease (CD) is a major public health problem affecting at least 1% of the general population and leading to significant morbidity and mortality...
  37. Validation of Peripheral Microparticles as Novel Biomarkers of Celiac Disease Act
    DANIEL ALEXANDER LEFFLER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Celiac disease is a T cell mediated immune disorder triggered by dietary gluten intake that affects approximately 1% of the US population and has significant deleterious effects on health and ..
  38. Characterizing the genetic architecture of childhood onset celiac disease using n
    Edwin Liu; Fiscal Year: 2010
    b>Celiac disease (CD) is a major public health problem affecting up to 1% of the general population and leading to significant morbidity and mortality...
  39. MONONUCLEAR PHAGOCYTE FUNCTION IN IMMUNOLOGIC DISEASES
    Robert P Kimberly; Fiscal Year: 2010
    ..for the gamma-chain associated receptors, to determine their functional characteristics and to establish their association with altered host defense and autoimmune disease (eg, rheumatoid arthritis, celiac disease, systemic vasculitis).
  40. STRUCTURAL STUDY OF HLA-DQ2 AND AN ASSOCIATED COMPLEX
    Irimpan I Mathews; Fiscal Year: 2011
    ..One of the diseases with the strongest association with particular MHC alleles is celiac disease, for which there is also mechanistic insight into the basis for the human leukocyte antigen (HLA) association...
  41. Function of Myosin-X in Intestinal Apical Domain Assembly
    KATY LIU; Fiscal Year: 2013
    ..of the apical domain alters its selective barrier function: malabsorption by microvilli is evident in celiac disease and microvillous inclusion disease, and disruption of the apical junction barrier contributes to the ..
  42. Themis Regulation of Thymocyte Selection
    NICHOLAS R GASCOIGNE; Fiscal Year: 2011
    ..to be of importance to medicine as a single nucleotide polymorphism in THEMIS is strongly associated with celiac disease. Themis appears to act by altering the sensitivity of the T cell receptor to ligands that would normally be at ..
  43. The TEDDY study: Georgia/Florida clinical center
    Jin Xiong She; Fiscal Year: 2013
    ..1) Follow the TEDDY cohort of 8677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years;2) Collect all planned biological specimens and epidemiological data according to the ..
  44. GENETIC ANALYSIS OF ALTERED IMMUNITY IN CELIAC DISEASE
    JOSEPH MICHALSKI; Fiscal Year: 1990
    b>Celiac disease (or gluten sensitive enteropathy) is a debilitating gastrointestinal disorder in which an aberrant immune response to dietary gluten results in destruction of the jejunal mucosa...
  45. The Environmental Determinants of Diabetes in the Young (TEDDY) Colorado Clinical
    Marian J Rewers; Fiscal Year: 2013
    ..1) Follow the TEDDY cohort of 8677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years;2) Collect all planned biological specimens and epidemiological data according to the ..
  46. The Environmental Determinants of Diabetes in Youth: Washington Clinical Center
    William A Hagopian; Fiscal Year: 2013
    ..1) Follow the TEDDY cohort of 8,677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years;2) Collect all planned biological specimens and epidemiological data according to the ..
  47. Antibody Reprtoire Characterization in Celiac Disease
    Patrick S Daugherty; Fiscal Year: 2013
    ..antibody repertoire profiling microarrays for diagnosis, prognostication, and therapeutic monitoring of Celiac Disease. Using high-resolution antibody specificity data, novel self- and non-self antigens will be identified as the ..
  48. INVESTIGATION Of HUMAN COMPLEMENT
    CHESTER ALPER; Fiscal Year: 1999
    ..Finally, we plan to try to explain the evolution and genetic mechanisms of origin of haplotypes with the relatively rare variant of the second component of complement, C2 B. ..
  49. GENETIC ANALYSIS OF NORMAL AND MALIGNANT LYMPHOCYTES
    Edmond Yunis; Fiscal Year: 1991
    ..These studies will identify the possible involvement of negative regulatory sequences and transacting repressor mechanisms in the stable repression of Class II genes during myelomonocytic cell differentiation...
  50. Limited Competition for the Continuation of Clinical Centers for the Environment
    ANETTE ZIEGLER; Fiscal Year: 2013
    ..1) Follow the TEDDY cohort of 8677 high-risk children for development of islet autoimmunity and diabetes and celiac disease for 5 more years;2) Collect all planned biological specimens and epidemiological data according to the ..
  51. DERMATITIS HERPETIFORMIS AND THE MUCOSAL IMMUNE RESPONSE
    Russell Hall; Fiscal Year: 2005
    ..These studies will provide insights into the pathogenesis of DH and isolated GSE, the relationship between the MIR and the skin and factors important in controlling the mucosal immune response in man. ..
  52. CELIAC DISEASE IN OSTEOPOROSIS
    WILLIAM STENSON; Fiscal Year: 2004
    DESCRIPTION (Abstract of the application) There is compelling evidence that the prevalence of celiac disease in the general population in the United States is higher than is generally appreciated and that patients with the symptoms ..
  53. DERMATITIS HERPETIFORMIS & THE MUCOSAL IMMUNE RESPONSE
    Russell Hall; Fiscal Year: 1992
    ..These studies will provide insights into the pathophysiology of DH, the relationship of the serum and secretory IgA responses to mucosal antigen exposure and the role of HLA associations in autoimmune disease...
  54. Are IL-18 receptor-bearing CD8 T cells pathogenic in human Type 1 diabetes?
    NORA E SARVETNICK; Fiscal Year: 2011
    ..Second, IL-18 is a risk factor for other autoimmune diseases such as celiac disease. Third, evaluation of the IL-18 binding protein for its use in clinical trials has been performed, and the ..
  55. Timing of Gluten Intake In Infant Nutrition and Risk of Celiac Disease Autoimmuni
    Alessio Fasano; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten containing grains (i.e.;wheat, barley, and rye) in genetically susceptible individuals...
  56. MODELS IN POPULATION GENETICS
    Glenys Thomson; Fiscal Year: 2000
    ..diabetes mellitus, rheumatoid arthritis, multiple sclerosis, ankylosing spondylitis, hemochromatosis, celiac disease, and others...
  57. MOLECULAR AND BIOCHEMICAL ANALYSIS OF THE CANINE MHC
    John Wagner; Fiscal Year: 2001
    ..Class II expression will be initially studied using existing cross-reactive MAbs. ..
  58. Development of a LH-PCR Based Diagnostic for Inflammatory Bowel Disease
    Patrick Gillevet; Fiscal Year: 2007
    ..disease not limited to IBD but also in other areas such as colorectal carcinogenesis, intestinal infections, celiac disease, irritable bowel syndrome, prebiotic and probiotic therapies...
  59. 14th International Congress of Mucosal Immunology
    Richard Blumberg; Fiscal Year: 2009
    ..cytokines, urogenital immunology, pulmonary immunology, inflammation, allergy, inflammatory bowel disease, celiac disease, lymphocyte homing, cytokines and chemokines, inflammation, mucosal antibodies, ocular and upper airway ..
  60. Gluten Sensitivity in the Old Order Amish
    Daniel McBride; Fiscal Year: 2005
    Gluten-sensitive enteropathy (GSE; VIM 607202) or celiac disease (CD; MIM 212750) has been well recognized as a public health concern for some time in Europe...
  61. MicroRNAs in Giardia Pathogenesis
    Steven M Singer; Fiscal Year: 2010
    ..This information will provide new strategies for treating common diseases like celiac disease and inflammatory bowel disease as well as diarrheal diseases like Giardia.
  62. ASSESSING MUCOSAL SURFACE AREA IN CELIAC DISEASE
    Morteza Janghorbani; Fiscal Year: 2000
    ..a noninvasive method for quantitative assessment of the extent of intestinal mucosal surface area involved in celiac disease. The proposed approach is based on the hypothesis that under certain experimental conditions changes in ..
  63. HLA-DQ-derived RTLs for Treatment of Celiac Disease
    GREGORY BURROWS; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Celiac disease is an inflammatory autoimmune disease in which CD4+ T cells target, damage and eventually destroy the villous tissue structures of the small intestine, interfering with the ..
  64. A Test of Iron Malabsorption in Patients with IDA
    Morteza Janghorbani; Fiscal Year: 2005
    ..g celiac disease, H. pylori gastritis, or IDA patients refractory to iron supplementation, etc...