babesiosis

Summary

Summary: A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by PROTOZOANS of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS.

Top Publications

  1. ncbi Babesiosis in dogs and cats--expanding parasitological and clinical spectra
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
    Vet Parasitol 181:48-60. 2011
  2. pmc Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
  3. ncbi Transfusion-associated babesiosis in the United States: a description of cases
    Barbara L Herwaldt
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 155:509-19. 2011
  4. ncbi Babesiosis of cattle
    R Bock
    Tock Fever Centre, Animal and Plant Health Service, Queensland Department of Primary Industries and Fisheries, 280 Grindle Road, Wacol Qld 4076, Australia
    Parasitology 129:S247-69. 2004
  5. pmc Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission
    Alain Chauvin
    Ecole Nationale Veterinaire, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Res 40:37. 2009
  6. ncbi Genetic detection of Babesia bigemina from Mongolian cattle using apical membrane antigen-1 gene-based PCR assay
    Thillaiampalam Sivakumar
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 187:17-22. 2012
  7. ncbi Canine babesiosis in Europe: how many diseases?
    Vesna Matijatko
    Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia
    Trends Parasitol 28:99-105. 2012
  8. pmc Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies
    Patrick J Kelly
    Ross University School of Veterinary Medicine, St Kitts, West Indies
    PLoS ONE 8:e53450. 2013
  9. ncbi Multiplex polymerase chain reaction based assay for the detection of Babesia bigemina, Babesia bovis and Anaplasma marginale DNA in bovine blood
    J V Figueroa
    Department of Veterinary Microbiology, University of Missouri Columbia 65211
    Vet Parasitol 50:69-81. 1993
  10. ncbi Emerging perspectives in the research of bovine babesiosis and anaplasmosis
    Carlos E Suarez
    Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture, Pullman, WA 99164 6630, USA
    Vet Parasitol 180:109-25. 2011

Detail Information

Publications352 found, 100 shown here

  1. ncbi Babesiosis in dogs and cats--expanding parasitological and clinical spectra
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
    Vet Parasitol 181:48-60. 2011
    Canine babesiosis caused by different Babesia species is a protozoal tick-borne disease with worldwide distribution and global significance...
  2. pmc Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
    ..The genome sequence provides a greater understanding of B. bovis metabolism and potential avenues for drug therapies and vaccine development...
  3. ncbi Transfusion-associated babesiosis in the United States: a description of cases
    Barbara L Herwaldt
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 155:509-19. 2011
    b>Babesiosis is a potentially life-threatening disease caused by intraerythrocytic parasites, which usually are tickborne but also are transmissible by transfusion...
  4. ncbi Babesiosis of cattle
    R Bock
    Tock Fever Centre, Animal and Plant Health Service, Queensland Department of Primary Industries and Fisheries, 280 Grindle Road, Wacol Qld 4076, Australia
    Parasitology 129:S247-69. 2004
    Tick fever or cattle fever (babesiosis) is economically the most important arthropod-borne disease of cattle worldwide with vast areas of Australia, Africa, South and Central America and the United States continuously under threat...
  5. pmc Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission
    Alain Chauvin
    Ecole Nationale Veterinaire, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Res 40:37. 2009
    Babesia, the causal agent of babesiosis, are tick-borne apicomplexan protozoa. True babesiae (Babesia genus sensu stricto) are biologically characterized by direct development in erythrocytes and by transovarial transmission in the tick...
  6. ncbi Genetic detection of Babesia bigemina from Mongolian cattle using apical membrane antigen-1 gene-based PCR assay
    Thillaiampalam Sivakumar
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 187:17-22. 2012
    ..Furthermore, our findings also indicate that the AMA-1 nPCR assay may be a useful diagnostic tool for the specific detection of B. bigemina...
  7. ncbi Canine babesiosis in Europe: how many diseases?
    Vesna Matijatko
    Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia
    Trends Parasitol 28:99-105. 2012
    b>Babesiosis, recognized since ancient times as an important disease of livestock and more recently as an emerging disease in dogs worldwide, is caused by intraerythrocytic protozoa of the genus Babesia and is transmitted by ticks...
  8. pmc Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies
    Patrick J Kelly
    Ross University School of Veterinary Medicine, St Kitts, West Indies
    PLoS ONE 8:e53450. 2013
    ..Although tick-borne diseases are important causes of morbidity and mortality in dogs in tropical areas, there is little information on the agents causing these infections in the Caribbean...
  9. ncbi Multiplex polymerase chain reaction based assay for the detection of Babesia bigemina, Babesia bovis and Anaplasma marginale DNA in bovine blood
    J V Figueroa
    Department of Veterinary Microbiology, University of Missouri Columbia 65211
    Vet Parasitol 50:69-81. 1993
    ..bovis and A. marginale, respectively. Blood collected from cattle previously inoculated with B. bovis (4 years), A. marginale (2 years) and B. bigemina (1 year) was demonstrated to be latently infected by using the Multiplex PCR test...
  10. ncbi Emerging perspectives in the research of bovine babesiosis and anaplasmosis
    Carlos E Suarez
    Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture, Pullman, WA 99164 6630, USA
    Vet Parasitol 180:109-25. 2011
    ..In addition, acute babesiosis and anaplasmosis can be prevented quite effectively by combining tick control and vaccination with living ..
  11. pmc Human babesiosis
    Edouard Vannier
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Boston, MA 02111, USA
    Infect Dis Clin North Am 22:469-88, viii-ix. 2008
    Human babesiosis is an emerging intraerythrocytic infection caused by protozoal parasites transmitted by ixodid ticks...
  12. ncbi Human babesiosis in Europe: what clinicians need to know
    A Hildebrandt
    Medical University Laboratories, Institute of Medical Microbiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
    Infection 41:1057-72. 2013
    Although best known as an animal disease, human babesiosis is attracting increasing attention as a worldwide emerging zoonosis. Humans are commonly infected by the bite of ixodid ticks...
  13. ncbi At least two genetically distinct large Babesia species infective to sheep and goats in China
    A H Liu
    State Key Laboratory of Veterinary Etiological Biology and Gansu Provincal Key Laboratory of Veterinary Parasitology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 11, Lanzhou, Gansu 730046, China
    Vet Parasitol 147:246-51. 2007
    ..The results indicated that there are at least two distinct Babesia species groups-B. motasi and Babesia sp. Xinjiang, the latter was distinctly different from other ovine Babesia isolates from China with less than 86.6% identity...
  14. ncbi Foci report on indigenous Dermacentor reticulatus populations in Belgium and a preliminary study of associated babesiosis pathogens
    C Cochez
    Research Laboratory for Vector Borne Diseases, Queen Astrid Military Hospital, Brussels, Belgium
    Med Vet Entomol 26:355-8. 2012
    The occurrence of autochthonous clinical cases of canine and equine babesiosis in Belgium during the last two decades suggests that the vector of the pathogens responsible for these diseases, Dermacentor reticulatus (Ixodida: Ixodidae), ..
  15. pmc Infection with agents of human granulocytic ehrlichiosis, lyme disease, and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut
    K C Stafford
    The Connecticut Agricultural Experiment Station, New Haven, Connecticut 06504, USA
    J Clin Microbiol 37:2887-92. 1999
    ..leucopus...
  16. ncbi Phylogeny of sheep and goat Theileria and Babesia parasites
    Leonhard Schnittger
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Parasitol Res 91:398-406. 2003
    ..2 (China). The recently reported pathogenic sheep/goat Theileria sp. 1 (China) seems to be identical with a Theileria sp. isolated from Japanese serow. Furthermore, our results suggest that T. ovis represents a single species...
  17. ncbi Canine babesiosis
    A Lindsay Boozer
    Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Wire Road, Auburn, AL 36849, USA
    Vet Clin North Am Small Anim Pract 33:885-904, viii. 2003
    Canine babesiosis is a tickborne, protozoal, hemoparasitic disease that can cause varying degrees of hemolytic anemia, splenomegaly, thrombocytopenia, and fever. Babesia organisms frequently are classified as large or small...
  18. ncbi Genetic conservation of potentially immunogenic proteins among Brazilian isolates of Babesia bovis
    Carlos A N Ramos
    Laboratório de Doenças Parasitárias dos Animais Domésticos, Departamento de Medicina Veterinária UFRPE, Recife, PE 52171 900, Brazil
    Vet Parasitol 187:548-52. 2012
    Bovine babesiosis caused by Babesia bovis remains an important constraint for the development of cattle industries worldwide. Effective control can be achieved by vaccination with live attenuated phenotypes of the parasite...
  19. pmc Questionnaire-based survey on distribution and clinical incidence of canine babesiosis in France
    Lénaïg Halos
    Merial, 29 Avenue Tony Garnier, 69007, Lyon, France
    BMC Vet Res 9:41. 2013
    The causative agent of canine babesiosis is the protozoan Babesia canis, transmitted by the tick Dermacentor reticulatus within France...
  20. ncbi Epidemiological analysis of tick-borne diseases in Zambia
    Martin Simuunza
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Vet Parasitol 175:331-42. 2011
    ..tick-borne diseases of livestock in sub-Saharan Africa are East Coast fever (caused by Theileria parva), babesiosis (caused by Babesia bigemina and B...
  21. ncbi Evaluation of the in vitro growth-inhibitory effect of epoxomicin on Babesia parasites
    Mahmoud Aboulaila
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 167:19-27. 2010
    ..05) inhibition of the growth of B. microti at the non-toxic doses of 0.05 and 0.5mg/kg BW relative to control groups. Therefore, epoxomicin might be used for treatment of babesiosis.
  22. ncbi Detection of haemoparasites in cattle by reverse line blot hybridisation with a note on the distribution of ticks in Sicily
    K Georges
    Division of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.165, 3508 TD Utrecht, The Netherlands
    Vet Parasitol 99:273-86. 2001
    ..lusitanicum, Rhipicephalus sanguineus group, R. bursa, Dermacentor marginatus, Haemaphysalis punctata, B. annulatus and I. ricinus...
  23. ncbi Application of a reverse line blot assay to the study of haemoparasites in cattle in Uganda
    C A L Oura
    Department of Microbiology and Parasitology, Faculty of Vet Medicine, Makerere University, Kampala, Uganda
    Int J Parasitol 34:603-13. 2004
    ..mutans and possibly T. taurotragi and T. velifera, may also cause clinical disease. Overall, the results presented here highlight the complexity of tick-borne pathogen infections in cattle in Uganda...
  24. ncbi Characterization of the Babesia gibsoni P18 as a homologue of thrombospondin related adhesive protein
    Jinlin Zhou
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Mol Biochem Parasitol 148:190-8. 2006
    ..gibsoni and functionally important in merozoite invasion; this protein may be useful as a vaccine candidate against canine B. gibsoni infection...
  25. ncbi Preventing transfusion-transmitted babesiosis: preliminary experience of the first laboratory-based blood donor screening program
    Carolyn Young
    Department of Administration and Laboratory Department, Rhode Island Blood Center, RI, USA
    Transfusion 52:1523-9. 2012
    b>Babesiosis is the most common transfusion-transmitted infection reported to the Food and Drug Administration (FDA)...
  26. ncbi Detection of bovine babesiosis in Mozambique by a novel seminested hot-start PCR method
    Tiago M Martins
    UTPAM, INETI, Est Paço do Lumiar 1649 038 Lisboa, Portugal
    Vet Parasitol 153:225-30. 2008
    b>Babesiosis is a tick borne disease (TBD) caused by parasites of the genus Babesia, with considerable worldwide economic, medical, and veterinary impact...
  27. ncbi First survey for Babesia bovis and Babesia bigemina infection in cattle from Central and Southern regions of Portugal using serological and DNA detection methods
    Marta G Silva
    Biomolecular Diagnostic Laboratory, ITQB IBET, Universidade Nova de Lisboa, Av da Republica, apt 12, 2781 901 Oeiras, Portugal
    Vet Parasitol 166:66-72. 2009
    Incidence of bovine babesiosis in Portugal is currently unknown...
  28. pmc Probable congenital babesiosis in infant, new jersey, USA
    Sonia Sethi
    The Children s Hospital at Monmouth Medical Center, Long Branch, New Jersey, USA
    Emerg Infect Dis 15:788-91. 2009
    Only 2 neonates with transplacentally or perinatally acquired (congenital) babesiosis have been reported...
  29. ncbi Zoonotic babesiosis: overview of the disease and novel aspects of pathogen identity
    Jeremy Gray
    UCD School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland
    Ticks Tick Borne Dis 1:3-10. 2010
    b>Babesiosis is a zoonosis caused by tick-transmitted intraerythrocytic protozoa of the Phylum Apicomplexa...
  30. pmc Transmission studies of Babesia microti in Ixodes ricinus ticks and gerbils
    Jeremy Gray
    Department of Environmental Resource Management, Faculty of Agriculture, Belfield, Dublin 4, Ireland
    J Clin Microbiol 40:1259-63. 2002
    ..ricinus suggests that other European B. microti strains, in addition to the HK strain used here, are probably infective for I. ricinus, supporting the view that infection of humans with European B. microti may be a regular occurrence...
  31. ncbi Loop-mediated isothermal amplification (LAMP) detection of Babesia orientalis in water buffalo (Bubalus babalis, Linnaeus, 1758) in China
    Lan He
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Hubei, Wuhan, China
    Vet Parasitol 165:36-40. 2009
    ..While previously B. orientalis had not been reported north of the Yangtse River, our results show that B. orientalis has spread to the north of the river. This could pose a serious threat to the water buffalo industry...
  32. ncbi Naturally acquired babesiosis in a reindeer (Rangifer tarandus tarandus) herd in Great Britain
    C Langton
    Department of Veterinary Pathology, Royal Veterinary College, London, UK
    Parasitol Res 89:194-8. 2003
    A provisional diagnosis of babesiosis was made in a reindeer herd in Scotland when seven animals died during 1997 and 1998. Additional clinical cases occurred, but the animals recovered after treatment...
  33. ncbi Babesia--a historical overview
    Gerrit Uilenberg
    A Surgente, Route du Port, 20130 Cargèse Corse, France
    Vet Parasitol 138:3-10. 2006
    ..Babesia microti is not a Babesia and that it would be just as logical to speak of human theileriosis as of babesiosis. The small piroplasm of horses, long known as Babesia equi, is already commonly designated as Theileria equi...
  34. ncbi Canine babesiosis in France
    Gilles Bourdoiseau
    Unité de Parasitologie Mycologie Maladies Parasitaires, Ecole Nationale Veterinaire de Lyon, 1 av Bourgelat, 69280 Marcy l Etoile, France
    Vet Parasitol 138:118-25. 2006
    Canine babesiosis has a high prevalence in France and continues to constitute a diagnostic challenge. This paper presents essential data derived from epidemiological surveys in order to define the main features of this disease...
  35. ncbi Tick vitellogenin receptor reveals critical role in oocyte development and transovarial transmission of Babesia parasite
    Damdinsuren Boldbaatar
    Laboratory of Emerging Infectious Diseases, Department of Frontier Veterinary Medicine, Kagoshima University, Korimoto, Kagoshima, Japan
    Biochem Cell Biol 86:331-44. 2008
    ..These results indicate that HlVgR, which is produced by the developing oocytes, is essential for Vg uptake, egg development in the H. longicornis tick, and transovarial transmission of Babesia parasites...
  36. pmc Erythrocyte invasion by Babesia bovis merozoites is inhibited by polyclonal antisera directed against peptides derived from a homologue of Plasmodium falciparum apical membrane antigen 1
    Fasila R Gaffar
    Department of Infectious Diseases and Immunology, Utrecht University, 3508 TD, Utrecht, The Netherlands
    Infect Immun 72:2947-55. 2004
    ....
  37. pmc Babesia sp. EU1 from roe deer and transmission within Ixodes ricinus
    Sarah Bonnet
    Department of Santé Animale, Institut National de la Recherche Agronomique, Nantes, France
    Emerg Infect Dis 13:1208-10. 2007
    ..EU1 from blood samples of roe deer in France. This study provides evidence of transovarial and transstadial transmission of the parasite within Ixodes ricinus, which suggests that this tick could be a vector and reservoir of EU1...
  38. pmc Development and evaluation of a seminested PCR for detection and differentiation of Babesia gibsoni (Asian genotype) and B. canis DNA in canine blood samples
    Adam J Birkenheuer
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 1428, USA
    J Clin Microbiol 41:4172-7. 2003
    Canine babesiosis has recently been recognized as an emerging infectious disease of dogs in North America. We sought to develop a seminested PCR to detect and differentiate Babesia gibsoni (Asian genotype), B. canis subsp. vogeli, B...
  39. ncbi Development and evaluation of a nested PCR based on spherical body protein 2 gene for the diagnosis of Babesia bovis infection
    Mahmoud Aboulaila
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Vet Parasitol 169:45-50. 2010
    ..6% (127/145), while B. bovis RAP-1 gene nPCR detected 37.2% (51/145) of the total samples examined. This nPCR assay provides a good diagnostic tool for the laboratory diagnostic assessment of B. bovis infection in cattle worldwide...
  40. ncbi A fatal case of human babesiosis in Portugal: molecular and phylogenetic analysis
    S Centeno-Lima
    Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal
    Trop Med Int Health 8:760-4. 2003
    We report the first case of human babesiosis in Portugal. A 66-year-old splenectomized man was admitted to a Lisbon hospital after 1 week of fever, abdominal pain, anorexia and nausea...
  41. ncbi Detection of Babesia gibsoni and the canine small Babesia 'Spanish isolate' in blood samples obtained from dogs confiscated from dogfighting operations
    Todd J Yeagley
    Department of Veterinary Pathobiology, Center for Veterinary Health Science, Oklahoma State University, Stillwater, OK 74078, USA
    J Am Vet Med Assoc 235:535-9. 2009
    ..To determine the prevalence of Babesia gibsoni infection in dogs that were confiscated from dogfighting operations...
  42. ncbi Clinical management of canine babesiosis
    Ashley L Ayoob
    Department of Emergency and Critical Care Medicine, Animal Medical Center, New York, NY 10065, USA
    J Vet Emerg Crit Care (San Antonio) 20:77-89. 2010
    ..information regarding epidemiology, pathogenesis, and pathophysiology leading to the various clinical syndromes associated with canine babesiosis. Diagnosis, treatment, preventative strategies, and zoonotic implications are discussed.
  43. ncbi Development and evaluation of two nested PCR assays for the detection of Babesia bovis from cattle blood
    Mahmoud Aboulaila
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 172:65-70. 2010
    ..The nPCR assay of BV5650 was the most sensitive for the detection of B. bovis from the field samples. The BV5650 nPCR assay provides a good diagnostic tool for laboratory diagnostic assessment of B. bovis infection in cattle worldwide...
  44. ncbi Epidemiology of bovine tick-borne diseases in southern Italy
    Giuseppe Cringoli
    Dipartimento di Patologia e Sanita Animale, Universita degli Studi di Napoli Federico II, Italy
    Vet Res 33:421-8. 2002
    ..6) and Haemaphysalis punctata (8.4). The results showed that B. bigemina, A. marginale and their potential vectors are common in the area examined and indicated that there is a risk for animals imported from tick-borne disease-free areas...
  45. pmc Infection with a proposed new subspecies of Babesia canis, Babesia canis subsp. presentii, in domestic cats
    Gad Baneth
    School of Veterinary Medicine, Hebrew University, Rehovot 76100, Israel
    J Clin Microbiol 42:99-105. 2004
    ..canis present in dogs, we propose to identify the novel feline genotype of B. canis described in the present study as a new subspecies, B. canis subsp. presentii...
  46. ncbi Nitric oxide metabolites in naturally occurring canine babesiosis
    Linda S Jacobson
    Faculty of Veterinary Science, Department of Companion Animal Clinical Studies, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    Vet Parasitol 104:27-41. 2002
    b>Babesiosis, caused by the virulent haemoprotozoan parasite Babesia canis rossi, is an important disease of dogs in South Africa...
  47. pmc Serological expression cloning of novel immunoreactive antigens of Babesia microti
    M J Lodes
    Corixa Corporation, Seattle, Washington 98104, USA
    Infect Immun 68:2783-90. 2000
    Increased recognition of the prevalence of human babesiosis in the United States, together with rising concern about the potential for transmission of this infection by blood transfusion, has provided motivation to develop definitive ..
  48. ncbi First evidence and molecular characterization of Babesia vogeli in naturally infected dogs and Rhipicephalus sanguineus ticks in southern France
    M René
    Universite de Lyon, VetAgro Sup, Jeune Equipe Hémopathogènes Vectorisés, F 69280 Marcy l Etoile, France
    Vet Parasitol 187:399-407. 2012
    b>Babesiosis is an emerging tick-borne disease of animals and humans caused by intraerythrocytic protozoa of the genera Babesia and Theileria...
  49. pmc Molecular basis for variable expression of merozoite surface antigen gp45 among American isolates of Babesia bigemina
    T G Fisher
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Infect Immun 69:3782-90. 2001
    ..bigemina strains, and the latter mechanism is unique compared to prior mechanisms of antigenic polymorphism identified in babesial parasites...
  50. ncbi Do babesiosis and malaria share a common disease process?
    I A Clark
    Division of Molecular Biology and Biochemistry, School of Biological Sciences, Australian National University, Canberra, Australia ian
    Ann Trop Med Parasitol 92:483-8. 1998
    Clinical Confusion between human babesiosis and malaria is often reported in the literature...
  51. ncbi Canine babesiosis in South Africa: more than one disease. Does this serve as a model for falciparum malaria?
    F Reyers
    Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
    Ann Trop Med Parasitol 92:503-11. 1998
    South African canine babesiosis is caused by the virulent Babesia canis rossi...
  52. ncbi Phylogenetic relationships of Mongolian Babesia bovis isolates based on the merozoite surface antigen (MSA)-1, MSA-2b, and MSA-2c genes
    Khukhuu Altangerel
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 184:309-16. 2012
    ..Our findings indicate that effective preventative and control strategies are essential to control B. bovis infection in Mongolian cattle populations, and suggest that a careful approach must be adopted when using immunization techniques...
  53. pmc Vertical transmission of Babesia microti, United States
    Julie T Joseph
    New York Medical College, Valhalla, New York 10595, USA
    Emerg Infect Dis 18:1318-21. 2012
    b>Babesiosis is usually acquired from a tick bite or through a blood transfusion. We report a case of babesiosis in an infant for whom vertical transmission was suggested by evidence of Babesia spp...
  54. ncbi Autochthonous canine babesiosis in The Netherlands
    Tshepo P Matjila
    Division of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Vet Parasitol 131:23-9. 2005
    Outbreaks of autochthonous babesiosis, caused by Babesia canis, occurred in The Netherlands in the spring and autumn of 2004 affecting 23 dogs. Nineteen animals recovered after treatment, whereas four dogs died...
  55. ncbi Serological survey of Babesia bovis and Babesia bigemina in cattle in South Africa
    Mohamad Alaa Terkawi
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 182:337-42. 2011
    ..protein-1 (BbigRAP-1/CT) were proven to be highly reliable in the serological diagnoses of bovine babesiosis in South African cattle, as evidenced by the significant concordance rates when the results were compared to ..
  56. pmc Transport of Babesia venatorum-infected Ixodes ricinus to Norway by northward migrating passerine birds
    Gunnar Hasle
    Reiseklinikken Oslo Travel Clinic, St Olavs plass 3, 0165 Oslo, Norway
    Acta Vet Scand 53:41. 2011
    Bovine babesiosis is regarded as a limited health problem for Norwegian cows, and the incidence has decreased markedly since the 1930s. Rare cases of babesiosis in splenectomised humans from infection with Babesia divergens and B...
  57. ncbi Seroepidemiology of canine babesiosis and ehrlichiosis in a hospital population
    Silvia M Trapp
    Department of Veterinary Clinical Sciences, Universidade Estadual de Londrina, 86 051 970 Londrina, Parana, Brazil
    Vet Parasitol 140:223-30. 2006
    Canine ehrlichiosis and babesiosis have a worldwide distribution with geographic variation in prevalence and main clinical manifestations...
  58. ncbi Seroprevalence of Babesia bovis and Babesia bigemina in cattle in the Soutpansberg region, Limpopo Province, South Africa, associated with changes in vector-tick populations
    M H Tønnesen
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    J S Afr Vet Assoc 77:61-5. 2006
    ..bigemina. Those dip tanks/farms where only R. (B.) microplus was recorded had a significantly higher seroprevalence of B. bovis than those where both tick species were present...
  59. ncbi A PCR based survey of Babesia ovata in cattle from various Asian, African and South American countries
    Takeshi Yoshinari
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    J Vet Med Sci 75:211-4. 2013
    ..ovata AMA-1, and that amplicons from different geographical locations were conserved. Our findings highlight the importance of designing adequate strategies to control B. ovata infection in Japan, Mongolia, and Thailand...
  60. pmc Persistently infected calves as reservoirs for acquisition and transovarial transmission of Babesia bovis by Rhipicephalus (Boophilus) microplus
    Jeanne M Howell
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Clin Microbiol 45:3155-9. 2007
    ..If reintroduced into the United States, babesiosis would cause significant mortality in the naïve cattle population. In order to address the risk to U.S...
  61. pmc Babesias of red deer (Cervus elaphus) in Ireland
    Annetta Zintl
    UCD School of Biology and Environmental Science, University College Dublin, Ireland
    Vet Res 42:7. 2011
    ..divergens, in just over half of the 18S rRNA gene. The entire gene of this deer parasite should be analysed and transmission experiments undertaken before the infectivity of B. divergens for red deer can be confirmed...
  62. ncbi Real-time polymerase chain reaction based on msa2c gene for detection of Babesia bovis
    Carlos A N Ramos
    Embrapa Gado de Corte, BR 262km 4 CP 154, 79002 970 Campo Grande, MS, Brazil
    Vet Parasitol 176:79-83. 2011
    ..All animals raised on a tick-free facility were negative for B. bovis in the three tests. These results suggest that msa2c q-PCR is a useful test for the detection of B. bovis infection...
  63. ncbi Live vaccines against bovine babesiosis
    D T De Waal
    Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Vet Parasitol 138:88-96. 2006
    Bovine babesiosis is an important tick-borne disease caused by Babesia bovis, B. bigemina and B. divergens...
  64. ncbi Molecular and serologic evidence for Babesia bovis-like parasites in white-tailed deer (Odocoileus virginianus) in south Texas
    Christina M Ramos
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Parasitol 172:214-20. 2010
    ..undertaken to determine if white-tailed deer in south Texas harbor Babesia bovis, a causative agent of bovine babesiosis. Blood samples from free-ranging white-tailed deer (Odocoileus virginianus) on two ranches in LaSalle and Webb ..
  65. ncbi Development of effective living vaccines against bovine babesiosis--the longest field trial?
    L L Callow
    Animal Research Institute, Yeerongpilly, Queensland, Australia
    Int J Parasitol 27:747-67. 1997
    Between 1959 and 1996, research was performed to change a vaccine against babesiosis in Australia and to improve it as actual or threatened untoward field responses became apparent...
  66. ncbi Identification, genetic diversity and prevalence of Theileria and Babesia species in a sheep population from Northern Spain
    Daniel Nagore
    Department of Animal Health, Instituto Vasco de Investigación y Desarrollo Agrario Berreaga 1, 48160 Derio, Bizkaia, Spain
    Int J Parasitol 34:1059-67. 2004
    ..The widespread distribution of Theileria spp. in the studied sheep population suggests that the parasites involved are of relatively low pathogenicity, in contrast to what has been reported for Theileria sp. China 1 in other countries...
  67. ncbi The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
    ..with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases Society of America...
  68. pmc Correlation between tick density and pathogen endemicity, New Hampshire
    Seth T Walk
    University of Massachusetts, Amherst, Massachusetts, USA
    Emerg Infect Dis 15:585-7. 2009
    ..Pathogens were more prevalent in areas of high tick density, suggesting a correlation between tick establishment and pathogen endemicity. Infection rates in ticks correlated with disease frequency in humans...
  69. ncbi Development of TaqMan-based real-time PCR assays for diagnostic detection of Babesia bovis and Babesia bigemina
    Chulmin Kim
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Am J Trop Med Hyg 77:837-41. 2007
    ..assays using the TaqMan-system can therefore be practically implemented in the epidemiologic survey for bovine babesiosis. Further studies will be necessary to investigate the clinical value of this technique, especially for the ..
  70. ncbi Molecular survey of Babesia microti in wild rodents in central Croatia
    Relja Beck
    Department for Bacteriology and Parasitology, Croatian Veterinary Institute, Zagreb, Croatia
    Vector Borne Zoonotic Dis 11:81-3. 2011
    Babesia divergens and B. divergens-like organisms are the main causative agents of human babesiosis in Europe...
  71. ncbi Development and evaluation of real-time PCR assays for the quantitative detection of Babesia caballi and Theileria equi infections in horses from South Africa
    Raksha Bhoora
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, South Africa
    Vet Parasitol 168:201-11. 2010
    ..equi-specific qPCR assay could positively detect T. equi DNA in 80% of the samples. These results suggest that the qPCR assays are more sensitive than the RLB assay for the detection of T. equi and B. caballi infections in field samples...
  72. ncbi Babesiosis in humans: a treatment review
    Louis M Weiss
    Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 504 Forchheimer Building, Bronx, New York, 10461, USA
    Expert Opin Pharmacother 3:1109-15. 2002
    ..However, the treatment of babesiosis using a clindamycin-quinine combination has been successful...
  73. ncbi The prevention of transmission of Babesia canis canis by Dermacentor reticulatus ticks to dogs using a novel combination of fipronil, amitraz and (S)-methoprene
    Frans Jongejan
    Utrecht Centre for Tick borne Diseases UCTD, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Vet Parasitol 179:343-50. 2011
    ..Therefore, the treatment of dogs with CERTIFECT applied up to 28 days prior to infestation with D. reticulatus harbouring B. canis canis, successfully prevented the development of clinical signs of canine babesiosis.
  74. ncbi Artesunate, a potential drug for treatment of Babesia infection
    Youn Kyoung Goo
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Parasitol Int 59:481-6. 2010
    ..microti at doses equal to and greater than 10mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection...
  75. ncbi Repeated high dose imidocarb dipropionate treatment did not eliminate Babesia caballi from naturally infected horses as determined by PCR-reverse line blot hybridization
    C M Butler
    Department of Equine Sciences, Medicine Section, Utrecht University, PO Box 80 153, 3508 TD Utrecht, The Netherlands
    Vet Parasitol 151:320-2. 2008
    ..These results confirm that the CFT is not a suitable test for pre-import testing and that even high dose treatment with imidocarb may not be capable of eliminating B. caballi and T. equi infections from healthy carriers...
  76. pmc Babesiosis in Lower Hudson Valley, New York, USA
    Julie T Joseph
    Division of Infectious Diseases, New York Medical College, Valhalla, New York 10595, USA
    Emerg Infect Dis 17:843-7. 2011
    ..Lyme disease has been endemic to parts of the Lower Hudson Valley of New York, United States, for >2 decades, babesiosis has emerged there only since 2001...
  77. ncbi The molecular evidence of Babesia microti infection in small mammals collected in Slovenia
    D Duh
    Institute of Microbiology and Immunology, Medical Faculty, 1000 Ljubljana, Slovenia
    Parasitology 126:113-7. 2003
    ..flavicollis were indistinguishable from each other and identical with those previously described in I. ricinus ticks collected in Slovenia. The results of this study represent molecular evidence of B. microti in small mammals in Europe...
  78. ncbi Recent insights into alteration of red blood cells by Babesia bovis: moovin' forward
    Sejal Gohil
    Department of Microbiology, Monash University, Victoria, Australia
    Trends Parasitol 26:591-9. 2010
    ..Here, we bring together recent work on Babesia bovis parasites which are beginning to unravel the molecular mechanisms that underlie the pathogenesis of babesiosis and highlight some opportunities and challenges that lie ahead.
  79. ncbi Development of a loop-mediated isothermal amplification (LAMP) assay for rapid diagnosis of Babesia canis infections
    H Muller
    Division of Veterinary Infection Biology and Immunology, Research Center Borstel, Borstel, Germany
    Transbound Emerg Dis 57:63-5. 2010
    ..In this study, we aimed to establish a rapid and easy to perform DNA-based test using loop-mediated isothermal amplification to detect all three Babesia canis subspecies in one assay...
  80. ncbi Transstadial and transovarial persistence of Babesia divergens DNA in Ixodes ricinus ticks fed on infected blood in a new skin-feeding technique
    S Bonnet
    UMR ENVN INRA 1034, Ecole Nationale Veterinaire de Nantes, Interactions Hôte Parasite Milieu, Atlanpole La Chantrerie, B P 40706, 44307 Nantes Cedex 03, France
    Parasitology 134:197-207. 2007
    ..ricinus via membrane as well as in vitro transmission of B. divergens to its vector. The opportunities offered by the use of such a transmission model of a pathogen by I. ricinus are discussed...
  81. ncbi Babesiosis diagnosis and treatment
    Peter J Krause
    Department of Pediatrics, University of Connecticut School of Medicine, Farmington, USA
    Vector Borne Zoonotic Dis 3:45-51. 2003
    Human babesiosis due to Babesia microti is an emerging malaria-like infection that is endemic in parts of the northeastern and northcentral United States...
  82. ncbi Inhibitory effect of terpene nerolidol on the growth of Babesia parasites
    Mahmoud Aboulaila
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Parasitol Int 59:278-82. 2010
    ..05) inhibited the growth of B. microti at the dosage of 10 and 100mg/kg BW, while the inhibition was low compared with the high doses used. Therefore, nerolidol could not be used as a chemotherapeutic drug for babesiosis.
  83. ncbi PCR detection of granulocytic Anaplasma and Babesia in Ixodes ricinus ticks and birds in west-central Poland
    Bogumiła Skotarczak
    Departament of Genetics, Faculty of Biology, Szczecin University, al Piastow 40b, 71 065 Szczecin, Poland
    Ann Agric Environ Med 13:21-3. 2006
    ..In spite of the high level of infestation of birds by I. ricinus, it is clear that they do not constitute a competent reservoir of A. phagocytophilum and Babesia in WNP. Additionally, I. ricinus is not a significant vector in this area...
  84. ncbi Babesiosis in free-ranging chamois (Rupicapra r. rupicapra) from Switzerland
    Stefan Hoby
    Centre for Fish and Wildlife Health, Institute of Animal Pathology, Vetsuisse Faculty, University of Berne, Langgassstrasse 122, 3001 Bern, Switzerland
    Vet Parasitol 148:341-5. 2007
    ..This is the first report of fatal Babesia infections in chamois raising the question of an emerging disease in this species...
  85. ncbi Detection of Anaplasma platys and Babesia canis vogeli and their impact on platelet numbers in free-roaming dogs associated with remote Aboriginal communities in Australia
    G K Brown
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan NSW 2308, Australia
    Aust Vet J 84:321-5. 2006
    ....
  86. ncbi Detection of Babesia bigemina infection in strains of Rhipicephalus (Boophilus) microplus collected from outbreaks in south Texas
    F D Guerrero
    USDA ARS Knipling Bushland, US Livestock Insects Research Laboratory, Kerrville, TX 78028, USA
    Vet Parasitol 145:156-63. 2007
    ..We detected the presence of B. bigemina in all strains of R. microplus currently reared at the laboratory and 4 of 26 strains collected from infestation outbreaks in Texas by the U.S. Cattle Fever Tick Eradication Program...
  87. pmc Babesia bicornis sp. nov. and Theileria bicornis sp. nov.: tick-borne parasites associated with mortality in the black rhinoceros (Diceros bicornis)
    Ard M Nijhof
    Division of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Clin Microbiol 41:2249-54. 2003
    ..Screening of black rhinoceroses in South Africa revealed, in addition to B. bicornis, a second parasite, designated Theileria bicornis sp. nov...
  88. ncbi Babesia infection through blood transfusions: reports received by the US Food and Drug Administration, 1997-2007
    Diane M Gubernot
    Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20852 1448, USA
    Clin Infect Dis 48:25-30. 2009
    Human babesiosis is an illness with clinical manifestations that range from asymptomatic to fatal. Although babesiosis is not nationally notifiable, the US incidence appears to be increasing...
  89. ncbi Development of loop-mediated isothermal amplification (LAMP) method for diagnosis of equine piroplasmosis
    Andy Alhassan
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 143:155-60. 2007
    ..9% of the 37 samples collected from South Africa were LAMP positive for T. equi and B. caballi, respectively. These results suggest that LAMP could be a potential diagnostic tool for epidemiological studies of equine piroplasmosis...
  90. ncbi Babesiosis of wild carnivores and ungulates
    Banie L Penzhorn
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    Vet Parasitol 138:11-21. 2006
    ..Similarly black rhinos, which can harbour Babesia bicornis without ill effects, may develop clinical babesiosis during confinement after capture. Zoo-bred animals, which were not exposed to Babesia spp...
  91. ncbi Babesia canis canis and Babesia canis vogeli clinicopathological findings and DNA detection by means of PCR-RFLP in blood from Italian dogs suspected of tick-borne disease
    L Solano-Gallego
    Laboratorio d Analisi Veterinarie, Via sorio 114c, 35141 Padua, Italy
    Vet Parasitol 157:211-21. 2008
    ..We evaluated the majority of canine babesiosis cases by means of clinical history, physical examination, hematological, biochemical, serum electrophoresis, ..
  92. ncbi PCR-RFLP for the detection and differentiation of the canine piroplasm species and its use with filter paper-based technologies
    R Jefferies
    Australasian Centre for Companion Animal Research, Division of Health Sciences, Murdoch University, WA 6150, Australia
    Vet Parasitol 144:20-7. 2007
    ..The assay reported here has the potential to be standardised for routine screening of dogs for piroplasmosis...
  93. ncbi Presence of Mycoplasma haemofelis, Mycoplasma haemominutum and piroplasmids in cats from southern Europe: a molecular study
    A Criado-Fornelio
    Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Alcala de Henares, 28871, Alcala de Henares, Spain
    Vet Microbiol 93:307-17. 2003
    ..canis canis, 1 with Theileria annae, and 1 with B. canis canis and T. annae both)...
  94. ncbi Babesia microti-like infections are prevalent in North American foxes
    Adam J Birkenheuer
    Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27606, USA
    Vet Parasitol 172:179-82. 2010
    ..microti-like parasite to infect and induce disease in domestic dogs remains unknown. Further studies investigating the pathogenic potential of the North American B. microti-like parasite in domestic dogs are indicated...
  95. ncbi Babesiosis
    Peter J Krause
    University of Connecticut School of Medicine, Department of Pediatrics, Connecticut Children s Medical Center, Hartford, Connecticut, USA
    Med Clin North Am 86:361-73. 2002
    b>Babesiosis is an emerging infection caused by protozoal parasites and transmitted by the same tick that transmits Lyme disease...
  96. ncbi First case of babesiosis caused by Babesia canis canis in a dog from Norway
    Øivind Øines
    Section for Parasitology, National Veterinary Institute, Ullevaalsveien 68, PB 750 Sentrum, N 0106 Oslo, Norway
    Vet Parasitol 171:350-3. 2010
    An Irish setter from the Oslo area was presented to the clinic with signs of babesiosis, a few days after a tick bite. Blood analysis confirmed babesiosis...
  97. ncbi Detection of Babesia EU1 in Ixodes ricinus ticks in northern Italy
    Rudi Cassini
    Dipartimento di Scienze Sperimentali Veterinarie, Universita degli Studi di Padova, Viale dell Universita, 16, 35020 Legnaro PD, Italy
    Vet Parasitol 171:151-4. 2010
    ..Babesia EU1 estimated individual tick prevalence in the area is 0.85%. The finding that also in northern Italy the tick population is carrying Babesia EU1 suggests a wide geographical spreading of this zoonotic pathogen in Europe...
  98. ncbi Transfusion-transmitted babesiosis in the United States: summary of a workshop
    Diane M Gubernot
    Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20852, USA
    Transfusion 49:2759-71. 2009
    ..and Drug Administration organized a public workshop to discuss the various aspects of transfusion-transmitted babesiosis in the United States including the possible strategies to identify and defer blood donors who may have been ..
  99. ncbi Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease
    Peter J Krause
    Department of Pediatrics, Medicine, Clinical Microbiology, Genetics, and Developmental Biology, and The Center for Microbial Pathogenesis, University of Connecticut School of Medicine, Farmington, CT, USA
    Clin Infect Dis 34:1184-91. 2002
    ..for serologic and polymerase chain reaction (PCR) testing after developing symptoms of Lyme disease, human babesiosis, or human granulocytic ehrlichiosis (HGE)...
  100. pmc Seroprevalence of Babesia infections in humans exposed to ticks in midwestern Germany
    Klaus Peter Hunfeld
    Institute of Medical Microbiology, University Hospital of Frankfurt, D 60596 Frankfurt Main, Germany
    J Clin Microbiol 40:2431-6. 2002
    b>Babesiosis is considered to be an emerging tick-borne disease in humans worldwide...
  101. pmc Cultivation of Babesia and Babesia-like blood parasites: agents of an emerging zoonotic disease
    Frederick L Schuster
    Viral and Rickettsial Disease Laboratory, State of California Department of Health Services, Richmond, California 94804, USA
    Clin Microbiol Rev 15:365-73. 2002
    ....

Research Grants47

  1. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) among other pathogens. A. phagocytophilum and B...
  2. Tick feeding regulation by orthologous tick saliva serine protease inhibitors
    Albert Mulenga; Fiscal Year: 2013
    ..the emergence of major human tick borne diseases (TBD) in the United States, Lyme disease, human anaplasmosis, babesiosis and ehrlichiosis and the southern tick-associated rash illness (STARI) has been recognized...
  3. Development of a multivalent vaccine for mouse reservoirs of deer tick pathogens
    Linden T Hu; Fiscal Year: 2010
    Ixodes ticks serve as the vector for 3 human infections in the U.S.-- Lyme disease, Babesiosis and human granulocytic ehrlichiosis. The incidence of all three diseases has been increasing over the last decade...
  4. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Gabor Szalai; Fiscal Year: 2013
    ..PGSC has provided animals for investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plaque...
  5. The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia bovi
    KERRY SUE SONDGEROTH; Fiscal Year: 2011
    ..For blood-borne parasites such as malaria and babesiosis, both of which contribute very significantly to the global health burden in resource poor countries, ..
  6. Babesiosis Emergence in the United States
    MARIA ANA DIUK-WASSER; Fiscal Year: 2013
    PROJECT SUMMARY Intellectual Merit: Human babesiosis is a rapidly emerging tick-borne zoonosis in the United States caused by the protozoan Babesia microti and transmitted by Ixodes scapularis, the Lyme disease vector...
  7. Babesiosis: An Emerging Infectious Threat to Transfusion Medicine
    Cheryl Ann Lobo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Babesiosis is a zoonosis, a disease communicable from animals to man...
  8. Overwintering mortality of nymphal Ixodes scapularis, Lyme disease vector, in a c
    RICHARD S contact OSTFELD; Fiscal Year: 2010
    ..of three emerging infectious diseases in North America: Lyme disease, human granulocytic anaplasmosis, and babesiosis. It has long been hypothesized that the cold, dry winter conditions of northern and interior environments kill ..
  9. R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)
    Andrew Levin; Fiscal Year: 2012
    ..Human babesiosis is a malaria-like illness due to infection of red blood cells by various species of protozoan parasites ..
  10. LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALE
    Reginald Valdez; Fiscal Year: 1999
    ..Laboratory, has a long-term research record defining the pathogenesis and immunity of infection with bovine babesiosis, bovine anaplasmosis and bovine leukemia virus infection, and is also a committee member...
  11. Immunoassay for diagnosis of Babesia infection
    ANDREW E LEVIN; Fiscal Year: 2013
    ..b>Babesiosis is an emerging tick-borne parasitic disease which may cause severe to fatal illness in immunocompromised or ..
  12. Babesiosis as a model of age-related immunosenescence
    Henry H Wortis; Fiscal Year: 2012
    ..We developed a mouse model of human babesiosis due Babesia microti, an emerging infection particularly severe in the aged...
  13. 13th International Conference on Lyme Borreliosis and Other Tick-borne Diseases
    Linden T Hu; Fiscal Year: 2013
    ..The diseases included in this conference are Lyme borreliosis, babesiosis, human granulocytic anaplasmosis (ehrlichiosis) and tick-borne encephalitis...
  14. A prospective evaluation of chronic B.microti infection in seroreactive blood don
    EVAN MARTIN BLOCH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Babesiosis is a tick-borne, intraerythrocytic protozoan infection, caused by members of the Babesia genus...
  15. Coinfection of Tick-borne Diseases in Areas of Wisconsin
    DIANE CAPORALE; Fiscal Year: 2001
    DESCRIPTION (provided by the applicant): Close to 400 human cases of Lyme disease and several --cases of Babesiosis and Human Granulocytic Ehrlichiosis (HGE) are reported in the State of Wisconsin each year...
  16. NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS
    Raymond Houghton; Fiscal Year: 2001
    ..shown that many individuals infected with Lyme disease have co-infections with Babesia microti (agent of human babesiosis) and Ehrlichia, both of which are potentially fatal in immunocompromised individuals and have been shown to ..
  17. NATURAL HISTORY OF BABESIOSIS
    Peter Wettstein; Fiscal Year: 1999
    ..The specific aims enumerated here are oriented toward defining further the course of babesiosis in humans and in mouse models of acute and chronic infection that we are studying...
  18. TAS::75 0872::TAS SCREENING AND CONFIRMATORY TESTS FOR HUMAN BABESIA SBIR PHASE
    Andrew Levin; Fiscal Year: 2010
    Human babesiosis is a malaria-like illness due to infection of red blood cells by various species of protozoan parasites belonging to the genus Babesia. Most human infections reported in the United States are caused by B...
  19. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2007
    ..program's activities is to reduce the incidence of Lyme disease and other tick-borne diseases in including babesiosis and ehrlichiosis...
  20. BABESIOSIS AS A PARADIGM FOR THE EFFECTS OF AGING
    JEFFREY GELFAND; Fiscal Year: 2000
    b>Babesiosis is a malaria-like parasitic disease of increasing incidence in New England, the Upper Midwest and the Northwestern states of the Pacific Coast...
  21. TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
    Sam Telford; Fiscal Year: 2000
    ..of human granulocytic ehrlichiosis in coastal New England is cotransmitted with those of Lyme disease and human babesiosis. An Ehrlichia with molecular identity to one infecting humans in the upper Midwest was isolated from a Nantucket ..
  22. DEVELOPMENT OF PCR BASED ASSAY FOR BABESIOSIS
    BITA NAKHAI; Fiscal Year: 1999
    ..S. Although Lyme Disease is the most prevalent vector- borne disease, two additional diseases, Babesiosis and Ehrlichiosis are transmitted by the same tick vector and share the same host reservoir...
  23. Vaccination Against Ixodes scapularis Tick Bites
    Michel Ledizet; Fiscal Year: 2003
    ..burgdorferi. This tick also transmits the agents of human granulocytic ehrlichiosis and babesiosis. The purpose of this project is to develop an anti-I...
  24. TICK-BORNE DISEASE PANEL TEST
    Andrew Levin; Fiscal Year: 2000
    ..detect antibodies to the agents of Lyme disease, Human Granulocytic Ehrlichiosis, Human Monocytic Ehrlichiosis, Babesiosis, and Rocky Mountain Spotted Fever...
  25. HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.
    Russell Johnson; Fiscal Year: 2005
    ..equi and is transmitted by Ixodes scapularis, the same tick that transmits the agents of Lyme disease and babesiosis. The HGE agent infects blood polymorphonuclear neutrophils resulting in neutropenia and a thrombocytopenia...
  26. PHEROMONE/ACARICIDE MATRIX CONTROLS LYME DISEASE VECTOR
    John McLaughlin; Fiscal Year: 2003
    ..The target species, blacklegged tick transmits Lyme disease, two kinds of ehrlichiosis, and human babesiosis in the U.S...
  27. PHEROMONE/ACARICIDE MATRIX CONTROLS LYME DISEASE VECTOR
    John McLaughlin; Fiscal Year: 2000
    ..The target species, blacklegged tick, transmits Lyme disease, two kinds of ehrlichiosis, and human babesiosis in the U.S...
  28. Comparison of US and European Babesia divergens Isolates
    Patricia Holman; Fiscal Year: 2004
    ..provided by the applicant): Babesia divergens is a tick transmitted hemoprotozoan parasite that causes human Babesiosis in Europe. Neither B. divergens nor its vector tick are indigenous to the U.S...
  29. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    ..Although we shall focus on the agents of Lyme disease, babesiosis, human granulocytic ehrlichiosis and TBE-group arboviruses, we shall seek to document the presence of other tick-..
  30. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. International Congress on Microsporidiosis
    Louis Weiss; Fiscal Year: 2004
    ..Overall, the goal of this congress is to foster the exchange of information between these diverse groups of scientists leading to advances in research on these emergent pathogens. ..
  32. Assessing Community-Based Tick Control for LD Mitigation
    Thomas Mather; Fiscal Year: 2007
    ..Efforts will focus on identifying strategiesfor engaging the community and individuals at risk. ..
  33. The Role of Babesia bovis MSA-1 in Erythrocyte Invasion
    Tanya LeRoith; Fiscal Year: 2004
    ..The results of this project, as well as the transfection techniques that will be developed, will allow us to begin targeting regions of functional significance in these proteins for further study...
  34. Gene expression of Borrelia during Babesia coinfection
    James Coleman; Fiscal Year: 2004
    ..burgdorferi and B. microti alone and concurrently. ..
  35. Microsporidiosis:A Therapeutic Target
    Louis Weiss; Fiscal Year: 2003
    ....
  36. ROLE OF TICK SALIVA IN LYME DISEASE AND VACCINE STRATEGY
    Thomas Mather; Fiscal Year: 2006
    ..We expect these studies to lead to new vaccination strategies that combine tick and bacterial elements for preventing Lyme disease, and possibly a broader range of tick-transmitted infections. ..
  37. Generation of babesial surface protein diversity
    SHAWN BERENS; Fiscal Year: 2006
    ..The sponsors collaborate closely in research and have successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
  38. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ....
  39. A Therapeutic Target for Microsporidiosis
    Louis Weiss; Fiscal Year: 2007
    ..In addition, the approaches and methods developed in this R21 should also prove useful for studies on methionine aminopeptidases as therapeutic targets in other pathogenic protists. [unreadable] [unreadable] [unreadable]..
  40. C.elegans as a model system forC.neoformans pathogenesis
    Eleftherios Mylonakis; Fiscal Year: 2007
    ..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
  41. Second International Workshop on Microsporidia from Vertebrate and Invertebrate H
    Louis Weiss; Fiscal Year: 2007
    ..Overall, the goal of this[unreadable] congress is to foster the exchange of information between these diverse groups of[unreadable] scientists leading to advances in research on these emergent pathogens. ..
  42. Perpetuation of Francisella tularensis
    Sam R Telford; Fiscal Year: 2010
    ..Taken together, these observations will provide a basis for understanding how the agent of tularemia is perpetuated on Martha's Vineyard, and why pneumonic human disease is prevalent there. ..
  43. TOXOPLASMA ENCEPHALITIS IN AIDS: BRADYZOITE REGULATION
    Louis Weiss; Fiscal Year: 2009
    ....
  44. Modulation of Dendritic Cell Function by Cytomegalovirus
    JATIN VYAS; Fiscal Year: 2008
    ..The proposed program will allow the candidate to obtain the skills, knowledge and experience to become an independent investigator. ..
  45. Proximal determinants of risk for tularemia outbreaks
    Sam Telford; Fiscal Year: 2004
    ..tularensis in the environment; and, ultimately, a better understanding of F. tularensis-host interactions. ..