trypanosomiasis

Summary

Summary: Infection with protozoa of the genus TRYPANOSOMA.

Top Publications

  1. ncbi First outbreak of Trypanosoma evansi in camels in metropolitan France
    M Desquesnes
    Cirad and IRD, UR Trypanosomes, Montpellier, F 34000, France
    Vet Rec 162:750-2. 2008
  2. ncbi A new genotype of Trypanosoma cruzi associated with bats evidenced by phylogenetic analyses using SSU rDNA, cytochrome b and Histone H2B genes and genotyping based on ITS1 rDNA
    A Marcili
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo USP, SP, Brasil
    Parasitology 136:641-55. 2009
  3. ncbi Evolutionary insights from bat trypanosomes: morphological, developmental and phylogenetic evidence of a new species, Trypanosoma (Schizotrypanum) erneyi sp. nov., in African bats closely related to Trypanosoma (Schizotrypanum) cruzi and allied species
    Luciana Lima
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Protist 163:856-72. 2012
  4. ncbi Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)
    Jose Antonio Marin-Neto
    Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Am Heart J 156:37-43. 2008
  5. ncbi Applications of PCR-based tools for detection and identification of animal trypanosomes: a review and perspectives
    M Desquesnes
    Centre International de Recherche Agronomique pour le Développement Elevage et Médecine Vétérinaire Tropicale CIRAD EMVT CIRDES, 01BP 454, Bobo Dioulasso, Burkina Faso
    Vet Parasitol 109:213-31. 2002
  6. ncbi Phylogeny of Trypanosoma ( Megatrypanum ) theileri and related trypanosomes reveals lineages of isolates associated with artiodactyl hosts diverging on SSU and ITS ribosomal sequences
    A C Rodrigues
    Department of Parasitology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Parasitology 132:215-24. 2006
  7. ncbi The effect of Trypanosoma evansi infection on pig performance and vaccination against classical swine fever
    W G Holland
    Ghent University, Faculty of Veterinary Medicine, Department Virology Parasitology Immunology, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Parasitol 111:115-23. 2003
  8. pmc In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis
    Elmarie Myburgh
    Wellcome Trust Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS Negl Trop Dis 7:e2384. 2013
  9. ncbi Trypanosoma evansi and T. equiperdum: distribution, biology, treatment and phylogenetic relationship (a review)
    R Brun
    Swiss Tropical Institute, Basel
    Vet Parasitol 79:95-107. 1998
  10. pmc Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis
    Z Hao
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 98:12648-53. 2001

Detail Information

Publications247 found, 100 shown here

  1. ncbi First outbreak of Trypanosoma evansi in camels in metropolitan France
    M Desquesnes
    Cirad and IRD, UR Trypanosomes, Montpellier, F 34000, France
    Vet Rec 162:750-2. 2008
    ..No parasites were observed in other animals on the farm or on neighbouring farms, but some of the sheep on these farms were positive by PCR or serology...
  2. ncbi A new genotype of Trypanosoma cruzi associated with bats evidenced by phylogenetic analyses using SSU rDNA, cytochrome b and Histone H2B genes and genotyping based on ITS1 rDNA
    A Marcili
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo USP, SP, Brasil
    Parasitology 136:641-55. 2009
    ..Our findings indicate that the complexity of T. cruzi is larger than currently known, and confirmed bats as important reservoirs and potential source of T. cruzi infections to humans...
  3. ncbi Evolutionary insights from bat trypanosomes: morphological, developmental and phylogenetic evidence of a new species, Trypanosoma (Schizotrypanum) erneyi sp. nov., in African bats closely related to Trypanosoma (Schizotrypanum) cruzi and allied species
    Luciana Lima
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Protist 163:856-72. 2012
    ..cruzi in the New World...
  4. ncbi Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)
    Jose Antonio Marin-Neto
    Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Am Heart J 156:37-43. 2008
    ..However, the efficacy of trypanocidal therapy in preventing clinical complications in patients with preexisting cardiac disease is unknown...
  5. ncbi Applications of PCR-based tools for detection and identification of animal trypanosomes: a review and perspectives
    M Desquesnes
    Centre International de Recherche Agronomique pour le Développement Elevage et Médecine Vétérinaire Tropicale CIRAD EMVT CIRDES, 01BP 454, Bobo Dioulasso, Burkina Faso
    Vet Parasitol 109:213-31. 2002
    ..Further investigations are required to develop and optimise multi-species-specific diagnostic tools for trypanosomes, which could also serve as a model for such tools in other pathogens...
  6. ncbi Phylogeny of Trypanosoma ( Megatrypanum ) theileri and related trypanosomes reveals lineages of isolates associated with artiodactyl hosts diverging on SSU and ITS ribosomal sequences
    A C Rodrigues
    Department of Parasitology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    Parasitology 132:215-24. 2006
    ..Moreover, positioning of trypanosomes infecting tabanids in the T. theileri clade is consistent with the role of these flies as important vectors of these trypanosomes...
  7. ncbi The effect of Trypanosoma evansi infection on pig performance and vaccination against classical swine fever
    W G Holland
    Ghent University, Faculty of Veterinary Medicine, Department Virology Parasitology Immunology, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Parasitol 111:115-23. 2003
    ..evansi-endemic areas of Vietnam, and suggests that prior treatments with trypanocidal drugs to improve the efficacy of CSF vaccination, may be justified...
  8. pmc In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis
    Elmarie Myburgh
    Wellcome Trust Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS Negl Trop Dis 7:e2384. 2013
    HUMAN AFRICAN TRYPANOSOMIASIS (HAT) MANIFESTS IN TWO STAGES OF DISEASE: firstly, haemolymphatic, and secondly, an encephalitic phase involving the central nervous system (CNS)...
  9. ncbi Trypanosoma evansi and T. equiperdum: distribution, biology, treatment and phylogenetic relationship (a review)
    R Brun
    Swiss Tropical Institute, Basel
    Vet Parasitol 79:95-107. 1998
    ..The phylogenetic relationship between the two species and T. b. brucei is being discussed, and the hypothesis is proposed that T. evansi arose from a clone of T. equiperdum which lost its maxicircles...
  10. pmc Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis
    Z Hao
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 98:12648-53. 2001
    ..The results are discussed in relation to transgenic approaches proposed for modulating vector competence in tsetse...
  11. ncbi Less is more: restricted application of insecticide to cattle to improve the cost and efficacy of tsetse control
    S J Torr
    Natural Resources Institute, University of Greenwich, Chatham Maritime, UK
    Med Vet Entomol 21:53-64. 2007
    ..This would cut the cost of insecticide by 40%, improve efficacy by 27% and reduce the threats to non-target organisms and the enzootic stability of tick-borne diseases...
  12. pmc Transmission stages dominate trypanosome within-host dynamics during chronic infections
    Paula MacGregor
    Centre for Immunity, Infection, and Evolution, Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Cell Host Microbe 9:310-8. 2011
    ..Our data reveal the dominance of transmission stages throughout infection, a consequence being austere use of the parasite's antigen repertoire...
  13. ncbi Phylogenetic, morphological and behavioural analyses support host switching of Trypanosoma (Herpetosoma) lewisi from domestic rats to primates
    F Maia da Silva
    Departamento de Parasitologia, Universidade de Sao Paulo, Sao Paulo, Brazil
    Infect Genet Evol 10:522-9. 2010
    ..lewisi from their natural rodent species to primates. This and previous studies reporting T. lewisi in humans suggest that this trypanosome can cause sporadic and opportunistic flea-borne infection in primates...
  14. ncbi Cytokines in rats experimentally infected with Trypanosoma evansi
    Francine C Paim
    Laboratory of Veterinary Clinical Analysis LACVet, Federal University of Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Exp Parasitol 128:365-70. 2011
    ..These results suggest a synergism among IL-1, TNF-α and IFN-γ contributing to the development of anemia. This increase is associated with the regulation of immune responses against the parasite...
  15. ncbi Trypanosoma irwini n. sp (Sarcomastigophora: Trypanosomatidae) from the koala ( Phascolarctos cinereus)
    L M McInnes
    Division of Health Sciences, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Perth 6150, Western Australia
    Parasitology 136:875-85. 2009
    ..Based on biological and genetic characterization data, this trypanosome species infecting koalas is proposed to be a new species Trypanosome irwini n. sp...
  16. ncbi Immune responses to haemorrhagic septicaemia (HS) vaccination in Trypanosoma evansi infected buffalo-calves
    Lachhman D Singla
    Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India
    Trop Anim Health Prod 42:589-95. 2010
    ..Immunosuppressive effect to HS vaccination was observed in T. evansi-infected buffalo-calves, and trypanocidal therapy enabled the calves to mount the responses similar to uninfected controls...
  17. ncbi High mortality and lesions of the central nervous system in trypanosomosis by Trypanosoma vivax in Brazilian hair sheep
    G J N Galiza
    Veterinary Hospital, CSTR, Federal University of Campina Grande, Patos, Paraíba 58700 000, Brazil
    Vet Parasitol 182:359-63. 2011
    ..vivax was introduced to the farm and the susceptible flock by buffalos that were asymptomatic carriers of the infection; T. vivax was most likely transmitted by Tabanus spp. bites and also iatrogenically...
  18. ncbi Multilocus phylogeographical analysis of Trypanosoma (Megatrypanum) genotypes from sympatric cattle and water buffalo populations supports evolutionary host constraint and close phylogenetic relationships with genotypes found in other ruminants
    Herakles A Garcia
    Departamento de Parasitologia, Universidade de Sao Paulo, Instituto de Ciencias Biomedicas II, Av Prof Lineu Prestes 1374, 05508 900 Sao Paulo, SP, Brazil
    Int J Parasitol 41:1385-96. 2011
    ....
  19. ncbi Trypanosomiasis in Venezuelan water buffaloes: association of packed-cell volumes with seroprevalence and current trypanosome infection
    H Garcia
    Laboratorio de Hemoparásitos, Catedra de Parasitologia, Departamento de Patologia Veterinária, Facultad de Ciencias Veterinarias, Universidad Central de Venezuela, Apartado 4563 2101A, Maracay, Venezuela
    Ann Trop Med Parasitol 100:297-305. 2006
    The seroprevalence of trypanosomiasis and the prevalence of current trypanosome infection in water buffaloes from the most important livestock areas of Venezuela were evaluated by IFAT and the microhaematocrit centrifugation technique, ..
  20. ncbi Trypanosoma evansi: recent outbreaks in Europe
    Carlos Gutierrez
    University of Las Palmas de Gran Canaria, Department of Animal Medicine, 35413 Arucas, Las Palmas, Canary Islands, Spain
    Vet Parasitol 174:26-9. 2010
    ..Moreover, procedures including diagnosis, curative or preventive treatment and quarantine should be established to insure the status of the animals moving from a country to another...
  21. pmc Trypanosoma livingstonei: a new species from African bats supports the bat seeding hypothesis for the Trypanosoma cruzi clade
    Luciana Lima
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Parasit Vectors 6:221. 2013
    ..cruzi clade, which comprises species from a wide geographic and host range in South America, Africa and Europe, including bat-restricted species and the generalist agents of human American trypanosomosis T. cruzi and T. rangeli...
  22. pmc Morphological polymorphism of Trypanosoma copemani and description of the genetically diverse T. vegrandis sp. nov. from the critically endangered Australian potoroid, the brush-tailed bettong (Bettongia penicillata (Gray, 1837))
    Craig K Thompson
    School of Veterinary and Life Sciences, Murdoch University, South Street, Western Australia, 6150, Australia
    Parasit Vectors 6:121. 2013
    ..At a species level, woylies are critically endangered and have declined by 90% since 1999. The predation of individuals made more vulnerable by disease is thought to be the primary cause of this decline, but remains to be proven...
  23. ncbi Domestic and wild mammals infection by Trypanosoma evansi in a pristine area of the Brazilian Pantanal region
    Heitor M Herrera
    Departamento de Protozoologia, Instituto Oswaldo Cruz FIOCRUZ, Pav Carlos Chagas, 3o andar Av Brasil 4365, CEP, 21045 900, Rio de Janeiro, Brazil
    Parasitol Res 96:121-6. 2005
    ..evansi (24.4% and 30.7%, respectively). Both sampling and extraction methods used herein, showed to be simple and efficient to be applied in epidemiological surveys using PCR...
  24. ncbi A nested PCR for the ssrRNA gene detects Trypanosoma binneyi in the platypus and Trypanosoma sp. in wombats and kangaroos in Australia
    H A Noyes
    Liverpool School of Tropical Medicine, UK
    Int J Parasitol 29:331-9. 1999
    ..Therefore this method could be suitable for rapidly screening host animals for the presence of trypanosomes and identifying the infecting strain...
  25. pmc Characterisation of the wildlife reservoir community for human and animal trypanosomiasis in the Luangwa Valley, Zambia
    Neil E Anderson
    Centre for Infectious Diseases, Division of Pathway Medicine, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 5:e1211. 2011
    Animal and human trypanosomiasis are constraints to both animal and human health in Sub-Saharan Africa, but there is little recent evidence as to how these parasites circulate in wild hosts in natural ecosystems...
  26. ncbi Interactions between tsetse and trypanosomes with implications for the control of trypanosomiasis
    Serap Aksoy
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Adv Parasitol 53:1-83. 2003
    ..Human African trypanosomiasis (HAT) is a zoonosis caused by Trypanosoma brucei rhodesiense in East Africa and T. b...
  27. ncbi Is there safety in numbers? The effect of cattle herding on biting risk from tsetse flies
    S J Torr
    Natural Resources Institute, University of Greenwich, Greenwich, U K
    Med Vet Entomol 21:301-11. 2007
    ..transmit species of Trypanosoma which threaten 45-50 million cattle with trypanosomiasis. These livestock are subject to various herding practices which may affect biting rates on individual cattle ..
  28. ncbi Analysis of gene expression profiles in the liver and spleen of mice infected with Trypanosoma evansi by using a cDNA microarray
    San Qiang Li
    Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen Zhongshan University, Guangzhou 510275, People s Republic of China
    Parasitol Res 104:385-97. 2009
    ..Our results provide a comprehensive profile of changes in gene expression in the liver and spleen of mice infected with T. evansi and may be helpful in understanding the pathogenesis of Surra at a molecular level...
  29. ncbi Estimating the impact of Trypanosoma evansi infection (surra) on buffalo population dynamics in southern Philippines using data from cross-sectional surveys
    A P Dargantes
    School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia
    Int J Parasitol 39:1109-14. 2009
    ..In high risk areas, surra imposes significant financial losses due to reduced fertility, high mortality/removal rate and the necessity to import replacement buffaloes...
  30. ncbi A rare case of human trypanosomiasis caused by Trypanosoma evansi
    R M Powar
    Department of Microbiology, Government Medical College, Nagpur 440 003, Maharashtra, India
    Indian J Med Microbiol 24:72-4. 2006
    ..We are reporting an unusual case of trypanosomiasis from the rural parts of Chandrapur district in Maharashtra...
  31. ncbi The detection and PCR-based characterization of the parasites causing trypanosomiasis in water-buffalo herds in Venezuela
    H Garcia
    Laboratorio de Investigacion, Catedra de Parasitologia, Departamento de Patologia Veterinária, Facultad de Ciencias Veterinarias, Universidad Central de Venezuela
    Ann Trop Med Parasitol 99:359-70. 2005
    The usefulness of PCR-based assays for detecting trypanosomiasis in water buffaloes and other livestock was explored, under field conditions, in Venezuela...
  32. ncbi Identification of trypanosomes in wild animals from southern Cameroon using the polymerase chain reaction (PCR)
    S Herder
    LRCT IRD CIRAD, TA 207 G, Campus International de Baillarguet, F 34398 Montpellier, France
    Parasite 9:345-9. 2002
    ..monticola), in carnivores (Nandinia binotata and Genetta servalina) and in rodents (Cricetomys gambianus and Atherurus africanus). 13 species (54%) were carrying T. brucei s.l. identified as non-gambiense group 1...
  33. ncbi Trypanosoma caninum n. sp. (Protozoa: Kinetoplastida) isolated from intact skin of a domestic dog ( Canis familiaris) captured in Rio de Janeiro, Brazil
    M F Madeira
    Laboratório de Vigilância em Leishmanioses, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
    Parasitology 136:411-23. 2009
    ..Isoenzyme analysis at 8 loci demonstrated a very peculiar banding pattern clearly distinct from those of T. rangeli and T. cruzi. We conclude that this isolate is a new Trypanosoma species. The name T. caninum is suggested...
  34. ncbi A changing environment and the epidemiology of tsetse-transmitted livestock trypanosomiasis
    Peter Van den Bossche
    Institute of Tropical Medicine, Animal Health Department, Nationalestraat 155, 2000 Antwerp, Belgium
    Trends Parasitol 26:236-43. 2010
    ..In the case of tsetse-transmitted livestock trypanosomiasis these changes are a result of the encroachment of people and their livestock into tsetse-infected wild areas...
  35. ncbi A comparative evaluation of parasitological, serological and DNA amplification methods for diagnosis of natural Trypanosoma evansi infection in camels
    Narender Singh
    Department of Veterinary Parasitology, College of Veterinary and Animal Science, Bikaner 334 001, Rajasthan, India
    Vet Parasitol 126:365-73. 2004
    ..The history of intermittent fever, emaciation, oedema, poor body condition significantly correlated with positive serological status in ELISA as well as trypanosome DNA detection by PCR...
  36. ncbi Enzootiology of Trypanosoma evansi in Pantanal, Brazil
    H M Herrera
    Laboratório de Biologia de Tripanosomatídeos, Departamento de Protozoologia, FIOCRUZ RJ, Pavilhão Carlos Chagas 3 andar, Av Brasil 4365, CEP 21045 900, Rio de Janeiro, Brazil
    Vet Parasitol 125:263-75. 2004
    In order to better understand the enzootiology of trypanosomiasis caused by Trypanosoma evansi in the Brazilian Pantanal we examined domestic and wild mammals by microhematocrit centrifuge technique (MHCT), immunofluorescence antibody ..
  37. ncbi Phylogeographical, ecological and biological patterns shown by nuclear (ssrRNA and gGAPDH) and mitochondrial (Cyt b) genes of trypanosomes of the subgenus Schizotrypanum parasitic in Brazilian bats
    Manzelio Cavazzana
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    Int J Parasitol 40:345-55. 2010
    ..Trypanosoma cruzi (18.2%) was found mainly in vespertilionid and phyllostomid bats from the Pantanal/Cerrado and the Atlantic Forest (Central to Southeast), with a few isolates from Amazonia...
  38. ncbi Trypanosomes in a declining species of threatened Australian marsupial, the brush-tailed bettong Bettongia penicillata (Marsupialia: Potoroidae)
    A Smith
    WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, State Agricultural Biotechnology Centre, School of Veterinary and Biomedical Sciences, Murdoch University, Western Australia 6150, Australia
    Parasitology 135:1329-35. 2008
    ..Although it appears unlikely that the parasite is solely responsible for the decline in woylie population size, it may (singularly or in conjunction with other infectious agents) predispose woylies to increased mortality...
  39. ncbi Trypanosoma rangeli isolates of bats from Central Brazil: genotyping and phylogenetic analysis enable description of a new lineage using spliced-leader gene sequences
    F Maia da Silva
    Departamento de Parasitologia, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Acta Trop 109:199-207. 2009
    ..To our knowledge, these two isolates are the earliest T. rangeli from bats and the first isolates from Central Brazil molecularly characterized. Rhodnius stali captured for this study was found infected by T. rangeli and T. cruzi...
  40. pmc Diagnosis of a Trypanosoma lewisi-like (Herpetosoma) infection in a sick infant from Thailand
    Nachai Sarataphan
    National Institute of Animal Health, Kaset Klang, Chatuchak, Bangkok 10900, Thailand
    J Med Microbiol 56:1118-21. 2007
    ..Human trypanosomiasis is not endemic to Thailand, so parasite identification was undertaken to determine likely sources of the ..
  41. ncbi Trypanosoma evansi in dromedary camel: with a case report of zoonosis in greater Cairo, Egypt
    Fouad M Haridy
    Department of Tropical Medicine, Faculty of Medicine, Al Azhar University, Nasr City, Egypt
    J Egypt Soc Parasitol 41:65-76. 2011
    Trypanosoma evansi (Steel, 1885) Balbiani, is the cause of trypanosomiasis (Surra) which multiples in the blood and body fluids. The incubation period varies from 7-15 days...
  42. ncbi Participatory investigations of bovine trypanosomiasis in Tana River District, Kenya
    A Catley
    International Institute for Environment and Development, London, UK
    Med Vet Entomol 16:55-66. 2002
    Participatory research on bovine trypanosomiasis was conducted with Orma pastoralists in Tana River District, Kenya...
  43. ncbi Molecular demonstration of Trypanosoma evansi and Trypanosoma lewisi DNA in wild rodents from Cambodia, Lao PDR and Thailand
    C Milocco
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement, Montpellier, France
    Transbound Emerg Dis 60:17-26. 2013
    ..evansi were recently described in India and by T. lewisi in India and Thailand. As sequencing PCR products is expensive, the development of new molecular and serological tools for rodents would be very useful...
  44. ncbi The influence of T. evansi infection on the immuno-responsiveness of experimentally infected water buffaloes
    W G Holland
    Faculty of Veterinary Medicine, Laboratory of Parasitology, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium
    Vet Parasitol 102:225-34. 2001
    ..Consequently, T. evansi infection might interfere with the development of protective immunity upon heterologous vaccinations and could explain the poor protection of Pasteurella-vaccinated buffaloes in T. evansi-endemic areas of Vietnam...
  45. ncbi Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection
    H Mekata
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Parasite Immunol 34:318-29. 2012
    ..Taken together, these results showed that a subset of regulatory DCs acted as a potential regulator of the inflammatory responses...
  46. pmc Isolation, cloning, and pathologic analysis of Trypanosoma evansi field isolates
    Hirohisa Mekata
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060 0818, Japan
    Parasitol Res 112:1513-21. 2013
    ..Our findings suggest that the epidemic of T. evansi in the Philippines is characterized by T. evansi strains with varying virulences from low to very high pathogenicity in cattle...
  47. pmc Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock
    John W Hargrove
    DST NRF Centre of Excellence in Epidemiological Modelling and Analysis SACEMA, University of Stellenbosch, Stellenbosch, South Africa
    PLoS Negl Trop Dis 6:e1615. 2012
    In Uganda, Rhodesian sleeping sickness, caused by Trypanosoma brucei rhodesiense, and animal trypanosomiasis caused by T. vivax and T. congolense, are being controlled by treating cattle with trypanocides and/or insecticides...
  48. pmc Genome hyperevolution and the success of a parasite
    J David Barry
    Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Ann N Y Acad Sci 1267:11-7. 2012
    ..Coordination of antigenic variation, and thereby transmission, occurs through networking of trypanosome traits expressed at different scales from molecules to host populations...
  49. ncbi Follicular degeneration in the ovaries of goats experimentally infected with Trypanosoma vivax from the Brazilian semi-arid region
    Carla M F Rodrigues
    Department of Animal Sciences, Federal Rural University of the Semiarid UFERSA, Av Francisco Mota, Br 110, Km 47 59, 59625 900 Mossoró, RN, Brazil
    Vet Parasitol 191:146-53. 2013
    ..In addition, through PCR, we detected T. vivax DNA in the ovarian tissues of the infected goats. Our findings contributed to understand the female reproductive failure associated with trypanosomosis caused by T. vivax...
  50. ncbi Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes
    April M Shiflett
    Josephine Bay Paul Center, Global Infectious Disease Program, Marine Biological Laboratory, Woods Hole, Massachussetts 02543, USA
    J Biol Chem 280:32578-85. 2005
    ..These studies show that HDLs can serve as platforms for the assembly of multiple synergistic proteins and that these assemblies may play a critical role in the evolution of primate-specific innate immunity to trypanosome infection...
  51. ncbi An iron-superoxide dismutase antigen-based serological screening of dogs indicates their potential role in the transmission of cutaneous leishmaniasis and trypanosomiasis in Yucatan, Mexico
    Silvia S Longoni
    Departamento de Parasitologia, Facultad de Ciencias, Universidad de Granada, Granada, Spain
    Vector Borne Zoonotic Dis 11:815-21. 2011
    ..is a significant prevalence of Trypanosoma cruzi, suggesting that the dog may be a source of transmission of trypanosomiasis. However, a more thorough epidemiological study on the dog population, both wild as well as urban, of the ..
  52. ncbi Characterisation of shops selling veterinary medicines in a tsetse-infested area of Kenya
    B Bett
    Centre for Tropical Veterinary Medicine, University of Edinburg, Easter Bush, Roslin Midlothian, Edinburg EH25 9RG, Scotland, UK
    Prev Vet Med 63:29-38. 2004
    ..We concluded that drug retailers were poorly equipped with the technical knowledge necessary for drug dispensation and advice...
  53. ncbi In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis
    J H Ansede
    Division of Drug Delivery and Disposition, School of Pharmacy, The University of North Carolina, Chapel Hill, NC 27599, USA
    Xenobiotica 35:211-26. 2005
    ..DB844), has potent oral activity in mouse models of both early-stage and CNS African trypanosomiasis. Metabolism of DB844 in human liver microsomes (HLM) was investigated using liquid chromatography-mass ..
  54. ncbi Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, leishmaniasis and trypanosomiasis
    M S Baptista
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, SP, Brasil
    Braz J Med Biol Res 44:1-10. 2011
    ....
  55. pmc Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure
    Lucio Marcello
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United Kingdom
    Genome Res 17:1344-52. 2007
    ..The small subfamily structure of the archive appears to be fundamental in providing the interacting donors for mosaic formation...
  56. ncbi An outbreak of abortions and high neonatal mortality associated with Trypanosoma evansi infection in dromedary camels in the Canary Islands
    C Gutierrez
    Department of Animal Medicine and Surgery, Veterinary Faculty, University of Las Palmas, 3416, Arucas, Las Palmas, Canary Islands, Spain
    Vet Parasitol 130:163-8. 2005
    ..Massive treatment would be recommended in the entire camel population in the Canary Islands (less than 2000 animals), as therapeutic or preventive measure, in order to control and to achieve an eventual eradication of the disease...
  57. ncbi Animal trypanosomiasis in South America. Current status, partnership, and information technology
    A M Davila
    Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, 21045 900, Brazil
    Ann N Y Acad Sci 916:199-212. 2000
    ..Because it can cause immunosuppression, the importance of trypanosomiasis control in ensuring success of vaccination campaigns against foot and mouth disease (FMD) in the Pantanal and ..
  58. ncbi Infection by Trypanosoma vivax in goats and sheep in the Brazilian semiarid region: from acute disease outbreak to chronic cryptic infection
    J S Batista
    Department of Animal Sciences, Federal Rural University of the Semi Arid, Avenida Francisco Mota, Mossoró, RN, Brazil
    Vet Parasitol 165:131-5. 2009
    ..vivax infection and also play a role as asymptomatic carriers and important sources of T. vivax to ruminants in general...
  59. ncbi Habitat fragmentation and haemoparasites in the common fruit bat, Artibeus jamaicensis (Phyllostomidae) in a tropical lowland forest in Panamá
    V M Cottontail
    Institute of Experimental Ecology, University of Ulm, Albert Einstein Allee 11, 89069 Ulm, Germany
    Parasitology 136:1133-45. 2009
    ....
  60. ncbi Phylogeny of snake trypanosomes inferred by SSU rDNA sequences, their possible transmission by phlebotomines, and taxonomic appraisal by molecular, cross-infection and morphological analysis
    L B Viola
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Parasitology 135:595-605. 2008
    ..The flaws of the current taxonomy of snake trypanosomes are discussed, and the need for molecular parameters to be adopted is emphasized. To our knowledge, this is the first molecular phylogenetic study of snake trypanosomes...
  61. ncbi Trypanosoma evansi control and containment in Australasia
    Simon A Reid
    Western Australian Biomedical Research Institute, Division of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia
    Trends Parasitol 18:219-24. 2002
    ..Surveillance for T. evansi in PNG and Australia, and its control in the Philippines is restricted by the poor sensitivity and inadequate validation of existing diagnostic tests and lack of information on the determinants of infection...
  62. ncbi Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response
    Toya Nath Baral
    Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Brussels, B 1050, Belgium
    J Infect Dis 195:1513-20. 2007
    ..documented that Trypanosoma evansi, the etiological agent of the livestock disease "surra," can cause human trypanosomiasis. In contrast to trypanosomes causing human African trypanosomiasis, T...
  63. ncbi Short report: Human trypanosomiasis caused by Trypanosoma evansi in a village in India: preliminary serologic survey of the local population
    Vijay R Shegokar
    Department of Microbiology, Government Medical College, Nagpur, India
    Am J Trop Med Hyg 75:869-70. 2006
    ..from the village of origin of the patient in India was performed using the card agglutination test for trypanosomiasis and T. evansi. A total of 410 (22...
  64. ncbi Host specificity of Trypanosoma (Herpetosoma) species: evidence that bank voles (Clethrionomys glareolus) carry only one T. (H.) evotomys 18S rRNA genotype but wood mice (Apodemus sylvaticus) carry at least two polyphyletic parasites
    H A Noyes
    Animal Genetics Laboratory, School of Biological Sciences, Donnan Laboratories, University of Liverpool, UK
    Parasitology 124:185-90. 2002
    ..microti of voles. Fifty-six fleas collected from the rodents were also screened for trypanosomes; 9 were infected with T. evotomys and 1 with T. grosi. One of the fleas infected with T. evotomys was collected from a wood mouse...
  65. ncbi Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasite
    J D Barry
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Scotland, UK
    Adv Parasitol 49:1-70. 2001
    ....
  66. ncbi Diagnosis of human trypanosomiasis, due to Trypanosoma brucei gambiense in central Africa, by the polymerase chain reaction
    L Penchenier
    OCEAC, BP 288, Yaounde, Cameroon
    Trans R Soc Trop Med Hyg 94:392-4. 2000
    ..Republic, we tested the polymerase chain reaction (PCR) on whole blood for the diagnosis of human African trypanosomiasis due to Trypanosoma brucei gambiense...
  67. ncbi Nitric oxide level, protein oxidation and antioxidant enzymes in rats infected by Trypanosoma evansi
    Aleksandro S Da Silva
    Department of Animal Science, Universidade do Estado de Santa Catarina, Brazil
    Exp Parasitol 132:166-70. 2012
    ..Based on the physiological role of NO(), we can conclude that its increased concentration is related to an inflammatory response against the parasite, once a redox imbalance was observed during infection...
  68. ncbi Comparison of serological tests for Trypanosoma evansi natural infections in water buffaloes from north Vietnam
    D Verloo
    Prince Leopold Institute of Tropical Medicine, Department of Parasitology, Nationalestraat 155, B 2000, Antwerpen, Belgium
    Vet Parasitol 92:87-96. 2000
    ..evansi specific antibodies. The ELISA/T. evansi with a 50% positivity cut-off and the CATT/T. evansi on the other hand, seem more appropriate to detect true infected water buffaloes...
  69. ncbi Camel trypanosomosis in Morocco 1: results of a first epidemiological survey
    T Atarhouch
    Département de Parasitologie et Maladies Parasitaires, Institut Agronomique et Veterinaire Hassan II, BP 6202, 10101, Rabat, Morocco
    Vet Parasitol 111:277-86. 2003
    ..The study showed that the Saharan provinces of Morocco were slightly affected by camel trypanosomosis but two hyperendemic foci, Zagora and Merzouga, were found to be sources of contamination for the surrounding regions...
  70. ncbi Abnormal biochemical and haematological indices in trypanosomiasis as a threat to herd production
    C C Ohaeri
    Department of Biological Sciences, Michael Okpara University of Agriculture Umudike, PMB 7267 Umuahia Abia State, Nigeria
    Vet Parasitol 177:199-202. 2011
    Blood samples were collected from 46 domestic ruminants comprising of 23 trypanosomiasis infected and 23 uninfected control groups to study some biochemical and haematological effects of trypanosomiasis under natural condition...
  71. ncbi Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives
    Maribel Navarro
    Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Drug Discov Today 15:1070-8. 2010
    ..opportunities to find new 'leads' against the major protozoan diseases such as malaria, leishmaniasis and trypanosomiasis. A few metal-based drugs are already available in this therapeutic area, and others are currently being ..
  72. ncbi RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate
    William H Witola
    Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Exp Parasitol 107:47-57. 2004
    ..Further, we show for the first time that RNAi gene silencing in T. evansi can be induced using plasmids designed for T. brucei. We also demonstrate the usefulness of real-time PCR in rapidly quantifying mRNA levels in trypanosomes...
  73. ncbi Morphological and molecular characterization of Trypanosoma copemani n. sp. (Trypanosomatidae) isolated from Gilbert's potoroo ( Potorous gilbertii) and quokka ( Setonix brachyurus)
    J M Austen
    School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, South Street, Murdoch, Western Australia, 6150
    Parasitology 136:783-92. 2009
    ..The new species is proposed to be named Trypanosoma copemani n. sp...
  74. ncbi Isolation of a Megatrypanum trypanosome from sika deer (Cervus nippon yesoensis) in Japan
    Shinichi Hatama
    Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido, Japan
    Vet Parasitol 149:56-64. 2007
    ..Phylogenetically TSD1 is closely related to T. theileri, a common trypanosome of cattle, but is distinguishable from T. theileri by some morphometrical and biological features...
  75. pmc Control of human African trypanosomiasis in the Quiçama focus, Angola
    Jose Antonio Ruiz
    Agencia Espanola de Coopercion International, Muxima Health Centre, Muxima, Angola
    Bull World Health Organ 80:738-45. 2002
    To update the epidemiological status of human African trypanosomiasis (HAT), also known as sleeping sickness, in the Quiçama focus, province of Bengo, Angola, and to establish a HAT control programme.
  76. ncbi A rare case of trypanosomiasis in a two month old infant in Mumbai, India
    Raminder Kaur
    National Institute of Communicable Diseases, 22, Sham Nath Marg, Delhi
    J Commun Dis 39:71-4. 2007
    Human Trypanosomiasis is a rare occurrence in India. In the cases reported so far the disease causative species have been the species infective to animals viz., Trypanosoma lewisi and Trypanosoma evansi...
  77. ncbi PCR amplification of RoTat 1.2 VSG gene in Trypanosoma evansi isolates in Kenya
    J M Ngaira
    Department of Biochemistry, Kenyatta University, P O Box 43844, Nairobi, Kenya
    Vet Parasitol 120:23-33. 2004
    ..2 VSG gene. All the four T. brucei samples examined were negative by PCR and Western blot. In conclusion, this study showed that the RoTat 1.2 VSG gene was absent from some T. evansi trypanosomes in Kenya...
  78. ncbi The inadvertent introduction into Australia of Trypanosoma nabiasi, the trypanosome of the European rabbit (Oryctolagus cuniculus), and its potential for biocontrol
    P B Hamilton
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
    Mol Ecol 14:3167-75. 2005
    ..In view of the environmental and economic damage caused by rabbits in Australia and other islands, the development of a virulent or genetically modified T. nabiasi should be considered to control rabbits...
  79. ncbi Bronchoalveolar lavage cytology from captive badgers
    Grainne McCarthy
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland
    Vet Clin Pathol 38:381-7. 2009
    ..Cytologic profiles for BAL fluid have not been reported for badgers and may be useful in understanding the pathogenesis of pulmonary diseases such as Mycobacterium bovis...
  80. ncbi Development and application of a quantitative real-time PCR for the diagnosis of Surra in water buffaloes
    Satoru Konnai
    Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Infect Genet Evol 9:449-52. 2009
    ..evansi...
  81. ncbi Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense
    Magdalena Radwanska
    Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    Am J Trop Med Hyg 67:289-95. 2002
    Progress in diagnosis, treatment, and epidemiology of human African trypanosomiasis (sleeping sickness) depends on the existence of specific and sensitive diagnostic tools...
  82. pmc Factors associated with acquisition of human infective and animal infective trypanosome infections in domestic livestock in Western Kenya
    Beatrix von Wissmann
    Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 5:e941. 2011
    b>Trypanosomiasis is regarded as a constraint on livestock production in Western Kenya where the responsibility for tsetse and trypanosomiasis control has increasingly shifted from the state to the individual livestock owner...
  83. ncbi Towards a rational policy for dealing with tsetse
    Stephen J Torr
    Natural Resources Institute, University of Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK
    Trends Parasitol 21:537-41. 2005
    ..development of bait technologies that enable livestock keepers to control tsetse flies and, hence, African trypanosomiasis. The techniques have, however, often been applied on too small a scale, without due regard to the realities ..
  84. ncbi Control of tsetse flies and trypanosomes using molecular genetics
    Serap Aksoy
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Vet Parasitol 115:125-45. 2003
    ..b>Trypanosomiasis management relies heavily on the control of its single insect vector, the tsetse fly...
  85. pmc Molecular epidemiology of camel trypanosomiasis based on ITS1 rDNA and RoTat 1.2 VSG gene in the Sudan
    Bashir Salim
    Department of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001 0020, Japan
    Parasit Vectors 4:31. 2011
    ....
  86. pmc No gold standard estimation of the sensitivity and specificity of two molecular diagnostic protocols for Trypanosoma brucei spp. in Western Kenya
    Barend Mark De Clare Bronsvoort
    The Roslin Institute and The Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian, United Kingdom
    PLoS ONE 5:e8628. 2010
    African animal trypanosomiasis is caused by a range of tsetse transmitted protozoan parasites includingTrypanosoma vivax, Trypanosoma congolense and Trypansoma brucei. In Western Kenya and other parts of East Africa two subspecies of T...
  87. ncbi Perspectives for new drugs against trypanosomiasis and leishmaniasis
    Michael P Barrett
    University of Glasgow, Institute of Biomedical and Life Sciences, Division of Infection and Immunity, The Joseph Black Building, Glasgow, G12 8QQ, U K
    Curr Top Med Chem 2:471-82. 2002
    ..Therefore we also discuss approaches to designing molecules that can specifically cross the plasma membrane of African trypanosomes via unusual nutrient transporters...
  88. ncbi Metal complexes as chemotherapeutic agents against tropical diseases: trypanosomiasis, malaria and leishmaniasis
    ROBERTO A SANCHEZ-DELGADO
    Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827 Caracas 1020 A, Venezuela
    Mini Rev Med Chem 4:23-30. 2004
    ..In this review, advances in the use of metal complexes for the treatment of trypanosomiasis, malaria, and leishmaniasis as important representatives of the general area of tropical diseases is described...
  89. ncbi [Neuroimaging and efficacy of treatment in advanced African trypanosomiasis]
    C Serrano-González
    Servicio de Neurologia, Hospital Miguel Servet, Zaragoza, Espana
    Rev Neurol 24:1554-7. 1996
    West African trypanosomiasis (WAT) is rare in Spain. Delay in its diagnosis and treatment leads to irreversible diffuse meningoencephalitis and finally death of the patients.
  90. ncbi Indigenous knowledge system for treatment of trypanosomiasis in Kaduna state of Nigeria
    S E Atawodi
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    J Ethnopharmacol 79:279-82. 2002
    A survey was carried out in Kaduna State of Nigeria to establish the indigenous knowledge system for treating trypanosomiasis in domestic animals...
  91. ncbi Molecular identification and phylogenetic analysis of Trypanosoma evansi from dromedary camels (Camelus dromedarius) in Egypt, a pilot study
    Said Amer
    Laboratory of Sustainable Environmental Biology, Field Centre Studies, Graduate School of Agricultural Science, Tohoku University, 232 3 Yomogida, Naruko Onsen, Osaki, Miyagi 989 6711, Japan
    Acta Trop 117:39-46. 2011
    Animal trypanosomiasis is one of the major constraints of livestock industry in developing countries...
  92. ncbi Oligopeptidase B: a processing peptidase involved in pathogenesis
    Theresa H T Coetzer
    Biochemistry, School of Biochemistry, Genetics, Microbiology and Plant Pathology, University of KwaZulu Natal Pietermaritzburg campus, Private Bag X01, Scottsville 3201, South Africa
    Biochimie 90:336-44. 2008
    ..This review highlights the structure-function properties of oligopeptidase B in context with its physiological and/or pathological roles which make the enzyme a promising drug target...
  93. ncbi Differential macrophage polarisation during parasitic infections in common carp (Cyprinus carpio L.)
    Maaike Joerink
    Department of Animal Sciences, Cell Biology and Immunology Group, Wageningen Institute of Animal Sciences, Wageningen University, P O Box 338, 6700 AH Wageningen, The Netherlands
    Fish Shellfish Immunol 21:561-71. 2006
    ..carassii-infected fish. Our results indicate that T. borreli-infected carp are more prone to increase nitrite production by caMF while T. carassii-infected fish are more prone to increase arginase activity by aaMF...
  94. ncbi Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    N Engl J Med 355:2752-6. 2006
    ..Trypanolytic activity was restored by the addition of recombinant APOL1. The lack of APOL1 explained the patient's infection with T. evansi...
  95. ncbi Genetic characterisation of Trypanosoma brucei s.l. using microsatellite typing: new perspectives for the molecular epidemiology of human African trypanosomiasis
    Mathurin Koffi
    Institut de Recherche pour le Developpement, Unité Mixte de Recherche IRD CIRAD 177, Programme Santé Animale, TA 207 G, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France
    Infect Genet Evol 7:675-84. 2007
    The pathogenic agent of human African trypanosomiasis (HAT) is a trypanosome belonging to the species Trypanosoma brucei s.l. Molecular methods developed for typing T. brucei s.l...
  96. ncbi Equine trypanosomosis in the Central River Division of The Gambia: a study of veterinary gate-clinic consultation records
    S Dhollander
    International Trypanotolerance Centre, PMB 14 Banjul, The Gambia
    Prev Vet Med 75:152-62. 2006
    ..The study showed that the analysis of consultation records at a gate-clinic can provide complementary information to conventional epidemiological studies in the same research area...
  97. ncbi Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report
    Prashant P Joshi
    Department of Medicine, Government Medical College, Nagpur, India
    Am J Trop Med Hyg 73:491-5. 2005
    ..of trypanosomes belonging to the species Trypanosoma evansi, which is normally a causative agent of animal trypanosomiasis known as surra...
  98. ncbi Parenteral transmission during excision and treatment of tuberculosis and trypanosomiasis may be responsible for the HIV-2 epidemic in Guinea-Bissau
    Jacques Pepin
    Department of Microbiology and Infectious Diseases and Center for International Health, Centre Hospitalier Universitaire 3001, University of Sherbrooke, 12th Avenue North, Sherbrooke, Quebec, Canada
    AIDS 20:1303-11. 2006
    ..We sought to verify the hypothesis that parenteral transmission was the key factor in the building-up of the HIV-2 epidemic...
  99. ncbi Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis
    Manar M Salem
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210 1291, USA
    Curr Med Chem 13:2571-98. 2006
    ..developing world are affected by diseases caused by the kinetoplastid parasites: the leishmaniases, African trypanosomiasis, and Chagas disease...
  100. ncbi Morphological and genetic differences of Trypanosoma in some Chinese freshwater fishes: difficulties of species identification
    Zemao Gu
    Laboratory of Healthy Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People s Republic of China
    Parasitol Res 101:723-30. 2007
    ..It was concluded that three species of trypanosomes, at least three genotypes occur in Niushan Lake fishes, and P. fulvidraco in this region appear to contain both types, although the identification of T. pseudobagri remains a problem...
  101. ncbi Predicted distribution and movement of Glossina palpalis palpalis (Diptera: Glossinidae) in the wet and dry seasons in the Kogo trypanosomiasis focus (Equatorial Guinea)
    Jorge Cano
    National Centre for Tropical Medicine and International Health, Instituto de Salud Carlos III, Sinesio Delgado 6, 28029, Madrid, Spain
    J Vector Ecol 32:218-25. 2007
    ..an effective instrument for reducing the density of the tsetse fly populations, although given that the Kogo trypanosomiasis focus extends from the southern Equatorial Guinea to northern Gabon, interventions need to be planned on a ..

Research Grants69

  1. Anatomy of replication control elements in trypanosomes
    PRADEEP PATNAIK; Fiscal Year: 2002
    ..In addition, animal trypanosomiasis in sub-Saharan Africa contributes to a severe deficit of milk and other cattle products...
  2. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..may also apply to other parasitic protozoa infecting humans, such as malaria, Chagas'disease (American Trypanosomiasis), and Sleeping Sickness (African Trypanosomiasis)...
  3. Characterize functions of T. brucei RAP1 and TRF in antigenic variation and telom
    Bibo Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei is a protozoan parasite that causes African trypanosomiasis in humans and nagana in cattle. In mammalian hosts, bloodstream form (BF) T...
  4. The role of polyphosphate and acidocalcisomes in Trypanosoma brucei
    Roberto Docampo; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Trypanosoma brucei is the causative agent of sleeping sickness or African trypanosomiasis. According to the World Health Organization, over 60 million persons in sub-Saharan Africa are at risk of ..
  5. Cytosine DNA Methylation and Transcriptional Repression in African Trypanosomes
    KEVIN MILITELLO; Fiscal Year: 2012
    ..provided by applicant): Trypanosoma brucei is the protozoan parasite responsible for Human African Trypanosomiasis (HAT), otherwise known as African Sleeping Sickness...
  6. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2013
    ..Tsetse are the vectors of trypanosomiasis in both humans and animals in sub-saharan Africa creating major health and economic problems...
  7. Lipid metabolism during tsetse reproduction
    JOSH B BENOIT; Fiscal Year: 2013
    ..Vaccine-based methods have not been successful for control of trypanosomiasis. A unique aspect of this disease vector is its K-strategy of reproduction...
  8. The Lysosome of Trypanosoma brucei: A Proteomic Analysis
    James D Bangs; Fiscal Year: 2012
    ..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness) and nagana in livestock...
  9. Tsetse Transmitted African Trypanosomiasis
    Serap Aksoy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sleeping sickness, also known as human African trypanosomiasis (HAT), is one of the most Neglected Tropical Diseases (NTDs) that has plagued human health in sub-Saharan Africa...
  10. Reprogramming of the Trypanosoma brucei epigenome during human infection: opportu
    Hugh George Patterton; Fiscal Year: 2013
    ..T. brucei causes African sleeping sickness or trypanosomiasis, and occurs in extensive parts of sub-Saharan Africa...
  11. Validation and development of trypanosomal phosphodiesterase inhibitors for treat
    Michael P Pollastri; Fiscal Year: 2013
    ..In particular, since the genome for Trypanosoma brucei (the causative parasite for Human African Trypanosomiasis (HAT)) and T...
  12. Global sumoylation analysis in Trypanosoma brucei
    David A Campbell; Fiscal Year: 2010
    ..several pathogens of medical importance, including the causative agents of human leishmaniasis, African trypanosomiasis and Chagas disease...
  13. Polyamine and trypanothione metabolism in Trypanosoma brucei
    Margaret A Phillips; Fiscal Year: 2013
    Human African trypanosomiasis (HAT) is caused by the parasitic protozoan, Trypanosoma brucei...
  14. Pathogenesis of Trypanosoma cruzi infection
    Roberto Docampo; Fiscal Year: 2013
    ..Millions of people are affected by this trypanosomiasis. No vaccines are available to prevent this disease and drug treatments have serious side effects and are not ..
  15. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    CHING CHUNG WANG; Fiscal Year: 2012
    ..brucei a useful model system for advanced basic research as well as a potential target for anti-trypanosomiasis chemotherapy. PUBLIC HEALTH RELEVANCE: African trypanosomes, the Trypanosoma brucei spp...
  16. Lysosomal biogenesis and function in African trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
  17. Regulation of cell division in Trypanosoma brucei
    Ziyin Li; Fiscal Year: 2011
    ..The outcome from these studies would not only have important biological significance, but also could provide novel targets for anti-trypanosomiasis chemotherapy.
  18. Parameters that govern initiation of VSG switching in T.brucei
    F Nina Papavasiliou; Fiscal Year: 2013
    ..provided by applicant): The parasitic protozoan Trypanosoma brucei is the causative agent of African trypanosomiasis which causes sleeping sickness in humans and Nagana in farm animals...
  19. Structural Analysis of the GPI Transamidase Complex
    Anant K Menon; Fiscal Year: 2012
    ..GPI-APs are needed for fungal cell viability and they are important in diseases such as trypanosomiasis, malaria and leishmaniasis that are caused by parasitic protozoa...
  20. Secretion, protein targeting, and lipid metabolism in African Trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..The WHO currently estimates that 60 million people in 36 countries are at risk of acquiring Human African Trypanosomiasis. Only a handful of drugs are in use for treatment, the best of which (eflornithine) is expensive and requires ..
  21. Targeting Trypanosoma brucei S-adenosylmethionine decarboxylase in Drug Discovery
    NAHIR VELEZ; Fiscal Year: 2012
    Human African Trypanosomiasis (HAT), commonly called sleeping sickness, is caused by single-celled parasites, Trypanosoma brucei, which are transmitted to humans by infected tsetse flies...
  22. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    Ching Wang; Fiscal Year: 2009
    ..brucei a useful model system for advanced basic T. anti-trypanosomiasis chemotherapy. research as well as a potential target for anti-trypanosomiasis chemotherapy. well O.0 x<3y ...
  23. RNA CAPPING IN TRYPANOSOMES
    Christian Tschudi; Fiscal Year: 2012
    ..focuses on African trypanosomes of the Trypanosoma brucei subspecies, the causative agents of human African trypanosomiasis, a fatal disease unless treated, with a calculated disease burden of about two million Disability Adjusted ..
  24. Targeting S-adenosylmethionine decarboxylase for HAT drug discovery
    Margaret A Phillips; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human African trypanosomiasis (HAT) is caused by the parasitic protozoan, Trypanosoma brucei...
  25. Methodology for Identification of Substrate-Competitive Kinase Inhibitors
    Matthew B Soellner; Fiscal Year: 2012
    ..and the Trypanosome PTKs are potential therapeutic targets for African sleeping sickness (human African trypanosomiasis, HAT)...
  26. Mechanisms of the Unusual Cytokinesis in Trypanosomes
    Ziyin Li; Fiscal Year: 2013
    ..The outcome from these studies would not only have important biological significance, but also could provide novel targets for anti-trypanosomiasis chemotherapy.
  27. Drug development of orally active anti-trypanosomiasis agents
    Bin Su; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): African trypanosomiasis, also known as sleeping sickness, is a vector-borne parasitic disease caused by Trypanosoma brucei...
  28. Development of Assay for High Throughput Screen of Parasite Glucose Transporter
    Scott M Landfear; Fiscal Year: 2010
    Parasitic diseases, including malaria, trypanosomiasis, and leishmaniasis, produce an enormous disease burden throughout the world, yet development of urgently needed new drugs has proceeded at a slow pace...
  29. CELLULAR AND MOLECULAR PARASITOLOGY TRAINING PROGRAM NIA
    Timothy P Yoshino; Fiscal Year: 2012
    ..models are available for study including those of major importance to health in the tropics: malaria, trypanosomiasis, schistosomiasis, filariasis and ascariasis...
  30. Evidence based control strategies of Sleeping Sickness vectors
    Serap Aksoy; Fiscal Year: 2012
    ..award (FIRCA) proposal is on tsetse fly population genetics in order to support the ongoing Human African Trypanosomiasis (HAT) control activities in East Africa...
  31. Selective Inhibitors of the Hexose Transporter from African Trypansomes
    Scott Landfear; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei causes the disease African trypanosomiasis that afflicts an estimated 50,000-70,000 individuals with occasional pandemics resulting in deaths of up to 800,000 individuals...
  32. Flagellar targeting and sensory function of a glucose transporter in L. mexicana.
    KHOA DANG TRAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Leishmaniasis, trypanosomiasis, and malaria are parasitic diseases that affect more than 500 million individuals worldwide and are major public health problems (Teixeira et al., 2006;Wellems et al...
  33. Ribosome profiling of Trypanosoma brucei
    Marilyn Parsons; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Trypanosoma brucei, the causative agent of African trypanosomiasis ("sleeping sickness"), causes more than 50,000 deaths annually...
  34. Molecular and functional characterization of olfaction genes in tsetse flies
    Serap Aksoy; Fiscal Year: 2013
    ..in Kenya at International Centre of Insect Physiology Ecology and Kenya Agricultural Research Institute - Trypanosomiasis Research Center in collaboration with Paul Mireji with companion grant being Global Infectious Diseases (GID) ..
  35. Sodalis glossinidius iron acquisition
    LAURA JANE RUNYEN-JANECKY; Fiscal Year: 2012
    ..trypanosome, and recent research suggests that paratransgenesis may be a useful control strategy for African trypanosomiasis. For these reasons, a more complete understanding of the nature of the Sodalis-tsetse symbiosis will yield ..
  36. Cross-Protective Immunity to African Trypanosomes
    John M Mansfield; Fiscal Year: 2012
    ..in our laboratory have opened a window of opportunity for immunological control or cure of African trypanosomiasis. The first is a discovery that temporally protective VSG-specific T cell responses are directed exclusively ..
  37. Structure-based Optimization of T. brucei methionyl tRNA Synthetase Inhibitors
    Erkang Fan; Fiscal Year: 2013
    ..The long term goal is to arrive at new therapeutics for treating human African trypanosomiasis caused by T. brucei infection...
  38. 2010 Biology of Host-Parasite Interactions Gordon Research Conference
    L David Sibley; Fiscal Year: 2010
    ..parasites and how these relate to human diseases including malaria, toxoplasmosis, African and American trypanosomiasis, leishmaniasis, trichomoniasis, giardiasis and entamoebiasis...
  39. Protein Kinases of a Trypanosome
    Kojo Mensa Wilmot; Fiscal Year: 2010
    ..Novel drugs are needed for treatment of human African trypanosomiasis, which is caused by the protozoan parasite Trypanosoma brucei...
  40. A role for chromatin factors in regulating antigenic variation in T. brucei.
    Danae Schulz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human African Trypanosomiasis (HAT), also known as sleeping sickness, is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. T...
  41. The role of PhoP-PhoQ in an insect-bacterial symbiosis
    Colin Dale; Fiscal Year: 2013
    ..in a novel control strategy, aimed at reducing the vectorial capabilities of tsetse flies, which are important vectors of African trypanosomiasis, causing sleeping sickness in man and nagana in domestic livestock.
  42. New molecular techniques for T. cruzi
    Huan Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma cruzi (T. cruzi) causes Chagas Disease (e.g., American Trypanosomiasis) in humans...
  43. Topoisomerases: Target for Antitrypanosomal Therapy
    Theresa Shapiro; Fiscal Year: 2009
    African trypanosomiasis is lethal if not treated and its incidence is increasing. Existing therapies are antique by contemporary standards and no vaccine is available...
  44. Applied Biosystems API5500 Triple Quadrupole Mass Spectrometer
    Walter C Hubbard; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): HIV/AIDS, tuberculosis (TB), malaria and trypanosomiasis are infectious diseases of major importance to international health causing tremendous disease burdens on populations globally...
  45. Phosphoinositides in the T. brucei Endomembrane System
    Julia K Gilden; Fiscal Year: 2013
    ..are parasitic protozoa responsible for causing human African trypanosomiasis (HAT, sleeping sickness) in humans and nagana in cattle and other livestock...
  46. Host-specific cell surface receptors on African trypanosomes
    Kent L Hill; Fiscal Year: 2013
    ..provided by applicant): The flagellated protozoan parasite Trypanosoma brucei is responsible for African trypanosomiasis, which causes widespread mortality and morbidity of humans and livestock in sub-Saharan Africa...
  47. Mechanisms of mitochondrial DNA replication licensing in trypanosomes
    Ziyin Li; Fiscal Year: 2013
    ..Most importantly, since no homologs of TbHslVU and its partners, VUP1 and VUP2, are found in humans, they are potential drug targets for anti-trypanosomiasis chemotherapy.
  48. Signaling GPI-phosphlipase C of a Trypanosome
    Kojo Mensa Wilmot; Fiscal Year: 2010
    ..brucei. Trypanosomes cause diseases that affect millions of people world-wide. Work described in this proposal may lead to discovery of new signaling pathways that may be targeted for treatment of human African trypanosomiasis.
  49. Drug Discovery for Protozoan Parasites
    JAMES WAVELL AIKEN; Fiscal Year: 2012
    ..new insights and challenges in the identification of novel drug targets for malaria, leishmaniasis, and trypanosomiasis. Integrated strategies combining target identification and validation with advances in structural biology, ..
  50. Using protein-DNA chimeras for HAT diagnosis
    DENNIS JOHN GRAB; Fiscal Year: 2010
    ..b. rhodesiense are pathogens responsible for human African trypanosomiasis (HAT). Death from HAT is inevitable if untreated...
  51. Drug Discovery for Human African Trypanosomiasis
    Richard Tidwell; Fiscal Year: 2013
    ..The overall goal of this project is to identify new pre-clinical drug candidates to treat human African trypanosomiasis (HAT, sleeping sickness), including stage 2 of the disease when the parasites have entered the central ..
  52. Genome wide assessment of essential genes in Trypanosoma brucei
    Kenneth D Stuart; Fiscal Year: 2012
    ..applicant): Trypanosoma brucei, a WHO category one pathogen (emerging and uncontrolled), causes human African trypanosomiasis (HAT, aka African Sleeping Sickness), which is invariably fatal unless treated...
  53. High Throughput Screen Development for Modulators of Heme Transporters
    Iqbal Hamza; Fiscal Year: 2011
    ..be used to establish the feasibility of targeting this pathway for the treatment of helminth infections, Trypanosomiasis, intestinal nematodes, kinetoplastid diseases, lymphatic filariasis, onchocerciasis, and Leishmaniasis, as ..
  54. Mitochondrial Targeting and Import of Trypanosome Alternative Oxidase (TAO)
    VANAE N HAMILTON; Fiscal Year: 2010
    ..African trypanosomiasis heavily affects sub-Saharan Africa and parts of India...
  55. Annual Woods Hole Immunoparasitology (WHIP) Meeting
    Phillip A Scott; Fiscal Year: 2012
    ..g. leishmaniasis, trypanosomiasis, toxoplasmosis, malaria) and helminths (e.g. schisotosomiasis, trichuris, filariasis)...
  56. Essential PK/PD Relationships of Antimalarial and Antitrypanosomal Drugs
    Theresa A Shapiro; Fiscal Year: 2013
    ..Although many fewer patients have African trypanosomiasis (sleeping sickness), this infection is uniformly fatal if not treated and current therapies are toxic, ..
  57. Development of HTS assay and screening paradigm to discover new kinase inhibitors
    David C Swinney; Fiscal Year: 2013
    ..assay and paradigm to identify protein kinase inhibitors for Trypanosoma brucei that causes Human African trypanosomiasis (HAT), or sleeping sickness...
  58. Diagnosis of gambiense HAT
    DENNIS JOHN GRAB; Fiscal Year: 2012
    Trypanosoma brucei gambiense and T. b. rhodesiense are pathogens responsible for human African trypanosomiasis (HAT or sleeping sickness). Death from HAT is inevitable if untreated...
  59. Mitochondrial inner membrane protein translocase in Trypanosoma brucei
    Minu Chaudhuri; Fiscal Year: 2013
    ..majority of mitochondrial proteins in Trypanosoma brucei, the infectious agent of a fatal disease (African trypanosomiasis) in human and domestic animals, are nuclear-encoded and need to be imported into mitochondria...
  60. Dynamic Ecological Simulation Model of Tsetse Transmitted Trypanosomosis in Kenya
    Joseph P Messina; Fiscal Year: 2010
    ..change, social systems, and ecological disturbance on the ecological distribution of tsetse flies and African Trypanosomiasis or sleeping sickness across Kenya...
  61. Next generation sequencing of East African trypanosomes to expand the molecular e
    Adalgisa Caccone; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human African trypanosomiasis, also known as sleeping sickness, is a zoonotic disease affecting thousands of people across sub-Saharan Africa and periodic epidemics have caused significant social and ..
  62. ANALYSIS OF THE TRYPANOSOMA BRUCEI GENOME USING TILING ARRAYS
    Christian Tschudi; Fiscal Year: 2009
    ..provided by applicant): This application focuses on African trypanosomes, the causative agents of African trypanosomiasis. The World Health Organization conservatively estimates that the disease burden of human African ..
  63. Controlling Fatty Acid Synthesis in African Trypanosomes
    KIMBERLY SUE PAUL; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: New drugs for Human African Trypanosomiasis (HAT) are desperately needed, but an incomplete understanding of this disease's pathogenesis limits ..
  64. TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN CARBOHYDRATES
    Herman van Halbeek; Fiscal Year: 1993
    African trypanosomiasis is a parasitic disease affecting large areas of the African continent. It presents a threat to man and drastically impedes effective cattle-rearing...
  65. Trypanosoma brucei-induced dyshematopoiesis: blocked B lymphopoiesis
    Samuel Black; Fiscal Year: 2009
    ..About 300,000 persons have trypanosomiasis at present and the disease threatens an additional 60 million individuals in sub-Saharan Africa as well as ..
  66. Regulation of mRNA Turnover in Trypanosomes
    Vivian Bellofatto; Fiscal Year: 2003
    b>Trypanosomiasis and Leishmaniasis are major diseases in developing countries throughout the world. In these areas 100,000 people are currently infected with trypanosomes...
  67. MECHANISMS OF PHOSPHOLIPASE A2 REGULATION
    John Bell; Fiscal Year: 1990
    ..hyperemia, inflammatory problems associated with burns and trauma, eczema, psoriasis, pancreatitis, trypanosomiasis, amoebiasis, myocardial infarction, ischemia, alveolar proteinasis, demyelinating disease, septic shock and ..
  68. RECOMBINANT TRYPANOSOMA CRUZI PROTEIN VACCINES
    LOUIS KIRCHHOFF; Fiscal Year: 1991
    American trypanosomiasis (Chagas' disease) is caused by Trypanosoma cruzi, a protozoan parasite transmitted by reduviid bugs...
  69. Automated analysis of cell cycle genes in Trypanosoma brucei
    LAWRENCE RUBEN; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Human African trypanosomiasis (HAT) is a WHO Category I disease (emerging or out of control). New therapies are sorely needed...