- Respiratory syncytial virus infection in elderly and high-risk adults
Ann R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
N Engl J Med 352:1749-59. 2005
..Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help in assessing the need for vaccine development...
- Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
Research Center on Asthma and COPD, Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
Am J Respir Crit Care Med 173:1114-21. 2006
..Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial...
- A newly discovered human pneumovirus isolated from young children with respiratory tract disease
B G van den Hoogen
Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
Nat Med 7:719-24. 2001
..Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years...
- Estimates of world-wide distribution of child deaths from acute respiratory infections
Brian G Williams
World Health Organization, 20 Avenue Appia, Geneva 27, CH 1211, Switzerland
Lancet Infect Dis 2:25-32. 2002
..This analysis suggests that throughout the world 1.9 million (95% CI 1.6-2.2 million) children died from ARI in 2000, 70% of them in Africa and southeast Asia...
- Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease
Academic Department of Respiratory Medicine and Virology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK
Am J Respir Crit Care Med 164:1618-23. 2001
..Prevention and early treatment of viral infections may lead to a decreased exacerbation frequency and morbidity associated with COPD...
- Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology
John S Tregoning
Centre for Infection, Department of Cellular and Molecular Medicine, St George s University of London, London, United Kingdom
Clin Microbiol Rev 23:74-98. 2010
..Finally, both the virus and the immune response contribute to damage to the lungs and subsequent disease, and therefore, any prevention or treatment needs to address both of these factors...
- Role of viral respiratory infections in asthma and asthma exacerbations
William W Busse
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Lancet 376:826-34. 2010
Viral respiratory tract infections are common and usually selflimited illnesses...
- Effectiveness of maternal influenza immunization in mothers and infants
International Centre for Diarrheal Disease Research, Dhaka, Bangladesh
N Engl J Med 359:1555-64. 2008
..We assessed the clinical effectiveness of inactivated influenza vaccine administered during pregnancy in Bangladesh...
- The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children
K M Neuzil
Department of Medicine, University of Washington School of Medicine, Seattle, USA
N Engl J Med 342:225-31. 2000
..We measured the disease burden of influenza in a large cohort of healthy children in the Tennessee Medicaid program who were younger than 15 years of age...
- Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
Academic Unit of Primary Health Care, NIHR National School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA
BMJ 340:c2096. 2010
..To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care...
- Nontuberculous mycobacteria in respiratory tract infections, eastern Asia
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Emerg Infect Dis 17:343-9. 2011
..This geographic variation is not well reflected in the American Thoracic Society criteria for NTM infections and could be incorporated in future guidelines...
- Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
JAMA 302:1059-66. 2009
In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs).
- Guidelines for the management of adult lower respiratory tract infections--full version
Department of Respiratory Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, UK
Clin Microbiol Infect 17:E1-59. 2011
..Background sections and graded evidence tables are also included. The target audience for the Guideline is thus all those whose routine practice includes the management of adult LRTI...
- Respiratory viral infections among pediatric inpatients and outpatients in Taiwan from 1997 to 1999
H P Tsai
National Health Research Institutes Tainan Virology Laboratory for Diagnosis and Research, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
J Clin Microbiol 39:111-8. 2001
..These data expand our understanding of the etiology of acute respiratory tract viral infections among in- and outpatients in a subtropical country and may contribute to the prevention and control of viral respiratory tract infections.
- Viral respiratory infections in hospitalized and community control children in Alaska
Rosalyn J Singleton
Alaska Native Tribal Health Consortium, Anchorage, Alaska
J Med Virol 82:1282-90. 2010
..Rhinovirus and adenovirus were detected in two-thirds of hospitalized children, but their frequent detection in control children made their role in respiratory hospitalization uncertain...
- Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
Department of Emergency Medicine, Harvard School of Public Health, Boston, MA, USA
Cochrane Database Syst Rev 9:CD007498. 2012
- Are meteorological parameters associated with acute respiratory tract infections?
Jean Baptist du Prel
Kinderklinik, Paediatrische Infektiologie and Zentrum Praeventive Paediatrie, Universitaetsmedizin, Johannes Gutenberg Universitaet, Mainz, Germany
Clin Infect Dis 49:861-8. 2009
Information on the onset of epidemics of acute respiratory tract infections (ARIs) is useful in timing preventive strategies (eg, the passive immunization of high-risk infants against respiratory syncytial virus [RSV])...
- Guidelines for the management of adult lower respiratory tract infections--summary
Department of Respiratory Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, UK
Clin Microbiol Infect 17:1-24. 2011
..The target audience for the Guideline is thus all those whose routine practice includes the management of adult LRTI...
- Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial
Primary Care and Population Sciences Division, University of Southampton, Southampton, UK
Lancet Infect Dis 13:123-9. 2013
..We aimed to compare the benefits and harms of amoxicillin for acute lower-respiratory-tract infection with those of placebo both overall and in patients aged 60 years or older...
- Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients
Department of Morphological and Clinical Sciences, Section of Microbiology, University of Pavia, Pavia, Italy
J Med Virol 82:153-6. 2010
..The results suggest that WU/KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients...
- Prevalence of human coronaviruses in adults with acute respiratory tract infections in Beijing, China
State Key Laboratory for Molecular Virology and Genetic Engineering and Dr Christophe Mérieux Laboratory, IPB, CAMS Fondation Mérieux, Institute of Pathogen Biology IPB, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College, Beijing, China
J Med Virol 83:291-7. 2011
Human coronaviruses (HCoVs) are a common etiological agent of acute respiratory tract infections. HCoV infections, especially those caused by the two HCoVs identified most recently, NL63 and HKU-1, have not been characterized fully...
- Human Metapneumovirus: lessons learned over the first decade
Dipl Biologe, Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Klinikum der Privaten Universität Witten Herdecke, Institut fur Pathologie, Cologne, Germany
Clin Microbiol Rev 24:734-54. 2011
..This review summarizes our current knowledge on HMPV, HMPV disease pathogenesis, and disease intervention strategies and identifies a number of areas with key questions to be addressed in the future...
- Antibiotic prescribing for acute cough: the effect of perceived patient demand
Fund for Scientific Research, Flanders, Belgium
Br J Gen Pract 56:183-90. 2006
..GPs decide whether or not to prescribe antibiotics for acute cough. Apart from clinical signs and symptoms, non-medical reasons influence this decision as well...
- Acute lower respiratory tract infection
Joseph P Mizgerd
Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 358:716-27. 2008
- Social contacts and mixing patterns relevant to the spread of infectious diseases
Microbiology Unit, Laboratoire National de Santé, Luxembourg, Luxembourg
PLoS Med 5:e74. 2008
..We conducted a population-based prospective survey of mixing patterns in eight European countries using a common paper-diary methodology...
- The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand
Alicia M Fry
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 5:e15098. 2010
..We describe the epidemiology of hospitalized RSV infections for all age groups from population-based surveillance in two rural provinces in Thailand...
- Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm
Werner C Albrich
Medical University Department of the University of Basel, Kantonsspital Aarau, Switzerland
BMC Infect Dis 11:112. 2011
..ProADM) confers additional prognostic information to established clinical risk scores in lower respiratory tract infections (LRTI)...
- Interventions to influence consulting and antibiotic use for acute respiratory tract infections in children: a systematic review and meta-analysis
Department of Family Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 7:e30334. 2012
b>Respiratory tract infections (RTIs) are common in children and generally self-limiting, yet often result in consultations to primary care...
- Enterovirus genotype EV-104 in humans, Italy, 2008-2009
Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico, San Matteo, Pavia, Italy
Emerg Infect Dis 16:1018-21. 2010
..EV-104 is closely related to human rhinoviruses; thus, both types of viruses should be sought in respiratory syndromes...
- Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
Merci M H Kusel
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, Australia
J Allergy Clin Immunol 119:1105-10. 2007
..Severe lower respiratory infections (LRIs) and atopic sensitization have been identified as independent risk factors for asthma...
- Correlation between bocavirus infection and humoral response, and co-infection with other respiratory viruses in children with acute respiratory infection
Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People s Republic of China
J Clin Virol 47:148-55. 2010
..Co-infection was frequently found in HBoV-positive patients. Thus, whether HBoV is responsible for the respiratory disease is still arguable...
- Childhood asthma after bacterial colonization of the airway in neonates
Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
N Engl J Med 357:1487-95. 2007
..We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life...
- Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation
Servicio de Microbiologia, Hospital Son Dureta, Instituto Universitario de Investigación en Ciencias de la Salud IUNICS, Palma de Mallorca, Spain
J Bacteriol 190:7910-7. 2008
..aeruginosa genome evolution and adaptation during CRI...
- Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh
International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
Toxicol Lett 185:197-202. 2009
..The effect seemed to be partially gender dependent. Arsenic exposure also affected breast milk content of trophic factors and maternal morbidity...
- Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses
Timothy P Welliver
MedImmune, Inc, Gaithersburg, MD, USA
J Infect Dis 195:1126-36. 2007
..It is widely believed that both viral replication and inappropriately enhanced immune responses contribute to disease severity. In infants, RSV LRTI is known to be more severe than influenza virus LRTI...
- Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen
Michael P Walsh
Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd, MSN 5B3, Manassas, Virginia 20110, USA
J Clin Microbiol 48:991-3. 2010
..4% HAdV-B14. Sporadic appearances as a re-emergent pathogen and misidentification as "HAdV-B11a" are due to this partial hexon...
- The role of viruses in acute exacerbations of asthma
David J Jackson
Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
J Allergy Clin Immunol 125:1178-87; quiz 1188-9. 2010
- Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua
Nathan L Yozwiak
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, USA
J Virol 84:9047-58. 2010
..Further experimentation is required to more fully characterize the pathogenic role, disease associations, and global distribution of EV109...
- Interactions between influenza and bacterial respiratory pathogens: implications for pandemic preparedness
John F Brundage
Army Medical Surveillance Activity, Washington, DC 20307 5001, USA
Lancet Infect Dis 6:303-12. 2006
- Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease
S D Aaron
Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
Am J Respir Crit Care Med 163:349-55. 2001
..Three of 14 patients (21%) had confirmed bacterial or viral respiratory tract infections. Patients with documented infection did not demonstrate greater increases in sputum levels of ..
- Frequent and prolonged shedding of bocavirus in young children attending daycare
Emily T Martin
Center for Clinical and Translational Research, Seattle Children s Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
J Infect Dis 201:1625-32. 2010
..Little is known about human bocavirus (HBoV) persistence and shedding and the association between HBoV detection and the onset and resolution of respiratory symptoms...
- New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses
University of Geneva Hospitals, Switzerland
Emerg Infect Dis 15:719-26. 2009
..This study clarifies the diversity and explains the reasons for evolution of these viruses...
- Proposed changes to management of lower respiratory tract infections in response to the Clostridium difficile epidemic
James D Chalmers
MRC Centre for Inflammation Research, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
J Antimicrob Chemother 65:608-18. 2010
..Lower respiratory tract infections (LRTIs) are the leading indication for antibiotic prescription in hospitals and are therefore a ..
- Using data on social contacts to estimate age-specific transmission parameters for respiratory-spread infectious agents
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Am J Epidemiol 164:936-44. 2006
..These findings have important implications for controlling future outbreaks of novel respiratory-spread infectious agents...
- Human milk probiotic Lactobacillus fermentum CECT5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants
Hospital Universitario Virgen de las Nieves, Granada, Spain
J Pediatr Gastroenterol Nutr 54:55-61. 2012
..The aim of the study was to examine the effects of a follow-on formula containing Lactobacillus fermentum CECT5716 (L. fermentum) on the incidence of infections in infants between the ages of 6 and 12 months...
- The economic burden of non-influenza-related viral respiratory tract infection in the United States
A Mark Fendrick
Division of General Internal Medicine, Department of Internal Medicine, School of Medicine, University of Michigan, 300 N Ingalls Bldg, Room 7E06, Ann Arbor, MI 48109 0376, USA
Arch Intern Med 163:487-94. 2003
..Our objectives were to obtain an updated incidence of non-influenza-related VRTI in the United States and to quantify the health care resource use (direct costs) and productivity losses (indirect costs) associated with these infections...
- Antibiotic prescribing for acute respiratory tract infections in primary care: a systematic review and meta-ethnography
Primary Medical Care, University of Southampton, Aldermoor Health Centre, Aldermoor Close, Southampton SO16 5ST, UK
J Antimicrob Chemother 66:2215-23. 2011
Numerous interventions have been developed to promote prudent antibiotic use for acute respiratory tract infections (ARTIs)...
- Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial
David R Murdoch
Department of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch 8011, New Zealand
JAMA 308:1333-9. 2012
..have reported an inverse association between serum 25-hydroxyvitamin D (25-OHD) levels and incidence of upper respiratory tract infections (URTIs). However, results of clinical trials of vitamin D supplementation have been inconclusive.
- Viral-bacterial interactions and risk of acute otitis media complicating upper respiratory tract infection
Melinda M Pettigrew
Yale School of Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
J Clin Microbiol 49:3750-5. 2011
..Acute otitis media prevention efforts should consider methods for reducing infections caused by respiratory syncytial virus, bocavirus, and adenovirus in addition to acute otitis media bacterial pathogens...
- Contribution of common and recently described respiratory viruses to annual hospitalizations in children in South Africa
Department of Medical Virology, University of Pretoria, South Africa
J Med Virol 83:1458-68. 2011
..RSV, hPMV, PIV-3, and influenza viruses had defined seasons while rhinovirus, adenovirus, and coronavirus infections occurred year round in this temporal region of sub-Saharan Africa...
- Nucleic acid amplification-based diagnosis of respiratory virus infections
James B Mahony
Regional Virology Laboratory, St Joseph s Healthcare Hamilton, 50 Charlton Ave East, Hamilton, ON, L8N 4A6, Canada
Expert Rev Anti Infect Ther 8:1273-92. 2010
..These resistance assays together with new viral load tests will enable clinical laboratories to provide physicians with important information for optimal treatment of patients...
- Epidemiology of human metapneumovirus
Jeffrey S Kahn
Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, P O Box 208064, New Haven, CT 06520 8064, USA
Clin Microbiol Rev 19:546-57. 2006
..The virus is associated with both upper and lower respiratory tract infections and may be a trigger for asthma...
- The effects of malnutrition on child mortality in developing countries
D L Pelletier
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
Bull World Health Organ 73:443-8. 1995
..The methodology provided in this paper makes it possible to estimate the effects of malnutrition on child mortality in any population for which prevalence data exist...
- Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values
Rogier R Jansen
Department of Medical Microbiology1 and Department of Pediatrics, 2 Academical Medical Centre, University of Amsterdam, Amsterdam, Netherlands
J Clin Microbiol 49:2631-6. 2011
..This suggests that defining cutoff levels should be feasible and represents the next necessary step for diagnosing viral respiratory infections using molecular tests...
- Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings
Carlos G Grijalva
Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave, Ste 2600, The Village at Vanderbilt, Nashville, TN 37232 2637, USA
JAMA 302:758-66. 2009
..During the 1990s, antibiotic prescriptions for acute respiratory tract infection (ARTI) decreased in the United States. The sustainability of those changes is unknown...
- WU and KI polyomavirus infections in pediatric hematology/oncology patients with acute respiratory tract illness
Department of Pediatrics, B158 The Children s Hospital and University of Colorado School of Medicine, Aurora, CO 80045, USA
J Clin Virol 52:28-32. 2011
..Other polyomaviruses (BKPyV and JCPyV) have been associated with illness in immunocompromised patients, and some studies suggest a higher prevalence of WUPyV and KIPyV in this population...
- Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis
Andrew T Pavia
Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Utah, Salt Lake City, UT 84108, USA
Clin Infect Dis 52:S284-9. 2011
..cause an enormous disease burden in children, and the role of respiratory viruses in serious lower respiratory tract infections (LRTIs) in older adults is increasingly appreciated...
- Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis
Division of Pulmonary Medicine, Department of Pediatrics, University of Washington, Seattle, USA
Pediatr Pulmonol 34:91-100. 2002
..These findings confirm reports from previous smaller studies of outcomes among young children with CF, and highlight the potential to decrease the morbidity and mortality of young patients with CF through early intervention...
- Effect of using an interactive booklet about childhood respiratory tract infections in primary care consultations on reconsulting and antibiotic prescribing: a cluster randomised controlled trial
Nick A Francis
Department of Primary Care and Public Health, School of Medicine, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff CF14 4XN
BMJ 339:b2885. 2009
To establish whether an interactive booklet on respiratory tract infections in children reduces reconsultation for the same illness episode, reduces antibiotic use, and affects future consulting intentions, while maintaining parental ..
- Identification of respiratory viruses in adults: nasopharyngeal versus oropharyngeal sampling
Pulmonary Unit, Soroka Medical Center, Beer Sheva 84101, Israel
J Clin Microbiol 47:3439-43. 2009
..1 +/- 17.8 years) were included. Of these, 550 were patients hospitalized for acute febrile lower respiratory tract infections and 450 were controls...
- Predicting the clinical course of suspected acute viral upper respiratory tract infection in children
Christopher C Butler
Department of General Practice, Cardiff University, Llanedeyrn Health Centre, Cardiff CF23 9PN, UK
Fam Pract 22:92-5. 2005
- Macrophage defences against respiratory tract infections
S B Gordon
Wellcome Trust Research Laboratory, University of Malawi, Queen Elizabeth Central Hospital, Blantyre, Malawi
Br Med Bull 61:45-61. 2002
..Macrophage function can be modulated by cytokines, environmental exposures, recent and chronic infection including HIV infection, drug therapy and gene transfer...
- Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses
Gastroenteritis and Respiratory Virus Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Clin Microbiol 46:533-9. 2008
..The assay was successfully applied in an investigation of a coincidental outbreak of HRV respiratory illness among laboratory staff...
- Effectiveness of influenza vaccination of children with recurrent respiratory tract infections in reducing respiratory-related morbidity within the households
Department of Pediatric I, University of Milan, Via Commenda 9, 20122, Milan, Italy
Vaccine 21:3162-8. 2003
..of influenza vaccination in reducing respiratory-related morbidity among children with recurrent respiratory tract infections (RRTIs) and their household contacts, 127 children aged 6 months-9 years (78 males; median age, 3...
- Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial
Valio Research and Development, PO Box 30, FIN-00039 Valio, Helsinki, Finland
BMJ 322:1327. 2001
..of days with respiratory and gastrointestinal symptoms, absences from day care because of illness, respiratory tract infections diagnosed by a doctor, and course of antibiotics...
- Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring
Center for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain
Epidemiology 23:64-71. 2012
..We assessed whether maternal circulating 25-hydroxyvitamin D (25[OH]D) concentrations in pregnancy are associated with risk of lower respiratory tract infections, wheezing, and asthma in the offspring.
- Human respiratory syncytial virus in children with acute respiratory tract infections in China
Rong Fang Zhang
School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China
J Clin Microbiol 48:4193-9. 2010
..and molecular characterization of human respiratory syncytial virus (HRSV) in children with acute respiratory tract infections (ARTIs) in China...
- Genetic variability in the G protein gene of group A and B respiratory syncytial viruses from India
Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India
J Clin Microbiol 44:3055-64. 2006
..78) than within the genotypes (dN/dS, 0.69). These are among the first molecular analyses of RSV strains from the second most populous country in the world and will be useful for comparisons to candidate vaccine strains...
- Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups
Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada
J Infect Dis 186:1330-4. 2002
..These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients...
- Variations in antibiotic prescribing and consultation rates for acute respiratory infection in UK general practices 1995-2000
STaRNet lead general practitioner and honorary senior lecturer, King s College London
Br J Gen Pract 55:603-8. 2005
..Antibiotic prescribing by GPs in the UK has declined since 1995...
- Clinical disease in children associated with newly described coronavirus subtypes
Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
Pediatrics 119:e70-6. 2007
..In this study we examined the prevalence of 4 human coronaviruses, including subtypes OC43, 229E, and the recently described NL63 and HKU1 in a pediatric population presenting to a children's hospital...
- Anthrax as a biological weapon, 2002: updated recommendations for management
Thomas V Inglesby
Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins University, Baltimore, MD 21202, USA
JAMA 287:2236-52. 2002
..To review and update consensus-based recommendations for medical and public health professionals following a Bacillus anthracis attack against a civilian population...
- Procalcitonin for guidance of antibiotic therapy
Harvard School of Public Health, MA, USA
Expert Rev Anti Infect Ther 8:575-87. 2010
..This review aims to provide physicians with an overview of the strengths and limitations of procalcitonin guidance for antibiotic therapy when used in different clinical settings and in patients with different underlying infections...
- Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays
M T Coiras
Laboratorio de Virus Respiratorios, Servicio de Virologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
J Med Virol 72:484-95. 2004
There is a need for rapid, sensitive, and accurate diagnosis of lower respiratory tract infections in children, elderly, and immunocompromised patients, who are susceptible to serious complications...
- Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial
Jochen W L Cals
Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, Netherlands
BMJ 338:b1374. 2009
..To assess the effect of general practitioner testing for C reactive protein (disease approach) and receiving training in enhanced communication skills (illness approach) on antibiotic prescribing for lower respiratory tract infection...
- Understanding the mechanisms of viral induced asthma: new therapeutic directions
Nicole G Hansbro
Priority Research Centre for Asthma and Respiratory Disease, Faculty of Health, The University of Newcastle, New South Wales 2308, Australia
Pharmacol Ther 117:313-53. 2008
..b>Respiratory tract infections by respiratory syncytial virus (RSV) and rhinovirus (RV) are widely implicated as common causes of the ..
- Identification of a third human polyomavirus
Laboratory for Clinical Microbiology, Department of Clinical Microbiology, Tumor and Cell Biology, L2 02, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
J Virol 81:4130-6. 2007
..This finding further illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types...
- Comparison of nasopharyngeal flocked swabs and aspirates for rapid diagnosis of respiratory viruses in children
K H Chan
Department of Microbiology, The University of Hong Kong and Queen Mary Hospital, Hong Kong SAR, China
J Clin Virol 42:65-9. 2008
..The quality of clinical specimens is a crucial determinant for virological diagnosis...
- [Viral etiology of 1165 hospitalized children with acute lower respiratory tract infection]
Ni guang Xiao
Department of Pediatrics, People s Hospital of Hunan Province, Changsha 410005, China
Zhongguo Dang Dai Er Ke Za Zhi 14:28-32. 2012
..To explore the viral etiology of acute low respiratory tract infection (ALRTI) among hospitalized children in Changsha of Hunan Province of China...
- Health Alliance for prudent antibiotic prescribing in patients with respiratory tract infections (HAPPY AUDIT) -impact of a non-randomised multifaceted intervention programme
Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
BMC Fam Pract 12:52. 2011
..The aim of this study was to evaluate the impact of a multifaceted intervention targeting general practitioners (GPs) and patients in six countries with different health organization and different prevalence of antibiotic resistance...
- Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae
Timothy F Murphy
Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
J Infect Dis 195:81-9. 2007
..In a prospective study, selected isolates of apparent H. influenzae had an altered phenotype. We tested the hypothesis that these variant strains were genetically different from typical H. influenzae...
- Viral and atypical bacterial detection in acute respiratory infection in children under five years
Patrícia G M Bezerra
Instituto de Medicina Integral Professor Fernando Figueira IMIP, Recife, Brazil
PLoS ONE 6:e18928. 2011
..This study aimed to determine the viral and atypical bacterial causes of different severities and clinical manifestations of ARI in preschool children from low-income families in North-East Brazil...
- Genetic diversity of human metapneumovirus over 4 consecutive years in Australia
Ian M Mackay
Queensland Paediatric Infectious Disease Laboratory, Royal Children s Hospital, University of Queensland, Queensland, Australia
J Infect Dis 193:1630-3. 2006
..chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001-2004...
- Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing
IFM Bioinformatics and Swedish e Science Research Centre SeRC, Linkoping University, Linkoping, Sweden
PLoS ONE 7:e30875. 2012
..to the Karolinska University Laboratory, Stockholm, Sweden from March 2004 to May 2005 for diagnosis of respiratory tract infections. We have used a metagenomic sequencing strategy to characterize viruses, as this provides the most ..
- Relative importance of nasopharyngeal versus oropharyngeal sampling for isolation of Streptococcus pneumoniae and Haemophilus influenzae from healthy and sick individuals varies with age
The Pediatric Infectious Disease Unit, Ben Gurion University of the Negev, Soroka University Medical Center, Beer Sheva, Israel
J Clin Microbiol 42:4604-9. 2004
..Culturing only one site significantly reduced the recovery of H. influenzae at all ages. NP cultures for S. pneumoniae detected close to 100% of isolates in children but only 58% of isolates in mothers...
- Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients
Bernadette G van den Hoogen
Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
J Infect Dis 188:1571-7. 2003
..Treatment with antibiotics and corticosteroids was reported more frequently in hMPV-infected children. From these data, we conclude that hMPV is an important pathogen associated with RTI...
- Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007
Dr Christophe Mérieux Laboratory, IPB, CAMS Fondation Mérieux and State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology IPB, Chinese Academy of Medical Sciences CAMS, Beijing, China
Clin Microbiol Infect 15:1146-53. 2009
..the aetiological role and epidemiological profile of common respiratory viruses in adults with acute respiratory tract infections (ARTIs), a 2-year study was conducted in Beijing, China, from May 2005 to July 2007...
- Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing
Key Laboratory for Laboratory Medicine of Ministry of Education, Institute of Medical Virology, Wenzhou Medical College, Wenzhou, Zhejiang, China
PLoS ONE 7:e32174. 2012
Acute respiratory tract infections (ARTIs) represent a serious global health burden. To date, few reports have addressed the prevalence of respiratory viruses (RVs) in adults with ARTIs attending an emergency department (ED)...
- Prevalence of human metapneumovirus in adults with acute respiratory tract infection in Beijing, China
State Key Laboratory of Molecular Virology and Genetic Engineering, Institute of Pathogen Biology IPB, Peking Union Medical College PUMC and Chinese Academy of Medical Sciences CAMS, 9 Dong Dan San Tiao, Dongcheng District, Beijing 100730, PR China
J Infect 64:96-103. 2012
To evaluate the prevalence and clinical manifestations of human metapneumovirus (hMPV) in immunocompetent Chinese adults with acute respiratory tract infections (ARTIs).
- Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial
Referral Center for Pediatric Gastroenterology and Nutrition, Children s Hospital Zagreb, Klaiceva 16, Zagreb, Croatia
Clin Nutr 29:312-6. 2010
The aim of our study was to investigate the role of Lactobacillus GG (LGG) in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers.
- Role of emerging respiratory viruses in children with severe acute wheezing
M L García-García
Pediatrics Department, Severo Ochoa Hospital, Madrid, Spain
Pediatr Pulmonol 45:585-91. 2010
..Acute wheezing episodes are frequently associated with respiratory viral infections in children. However, the role of the recently described respiratory viruses is not yet fully understood...
- Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection
Department of Medical Microbiology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
J Clin Virol 49:158-62. 2010
Human bocavirus 1 (HBoV1) has recently been detected in children with respiratory tract infections (RTI)...
- Human metapneumovirus infections in young and elderly adults
Ann R Falsey
Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
J Infect Dis 187:785-90. 2003
..In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years...
- Upsurge of human enterovirus 68 infections in patients with severe respiratory tract infections
Department of Medical Microbiology, Division of Clinical Virology, University Medical Center Groningen, The Netherlands
J Clin Virol 52:103-6. 2011
..During the autumn of 2010, we noticed an upsurge of EV68 infections in the Northern part of the Netherlands in patients with severe respiratory illness...
- Two-year prospective study of single infections and co-infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease
Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, and Istituto Scientifico San Raffaele, Milan, Italy
J Med Virol 80:716-23. 2008
- Upper respiratory tract infection is reduced in physically fit and active adults
David C Nieman
Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA
Br J Sports Med 45:987-92. 2011
..The purpose of this study was to monitor URTI symptoms and severity in a heterogeneous group of community adults and contrast across tertiles of physical activity and fitness levels while adjusting for potential confounders...
- Rapid detection and identification of 12 respiratory viruses using a dual priming oligonucleotide system-based multiplex PCR assay
Suk Ran Kim
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
J Virol Methods 156:111-6. 2009
..The Seeplex Respiratory Virus Detection assay represents a significant improvement over the conventional methods for the detection of a broad spectrum of respiratory viruses...
- Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
Eur Respir J 30:556-73. 2007
Used appropriately, biomarkers improve the assessment of respiratory tract infections and sepsis. Most prominently, circulating procalcitonin levels increase by a factor of several tens of thousands during sepsis...
- Comparison of nasopharyngeal and oropharyngeal swabs for the diagnosis of eight respiratory viruses by real-time reverse transcription-PCR assays
U S Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 6:e21610. 2011
..Many acute respiratory illness surveillance systems collect and test nasopharyngeal (NP) and/or oropharyngeal (OP) swab specimens, yet there are few studies assessing the relative measures of performance for NP versus OP specimens...
- High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France
Universite Paris Diderot, Sorbonne Paris Cité, Microbiology Department, Saint Louis Hospital, APHP, Paris, France
PLoS ONE 6:e23514. 2011
..Clinical observations are of little help to recognise myxovirus infection and implement appropriate prevention measures. The limited use of molecular tools underestimates the role of other common pathogens...
- Application of TaqMan low-density arrays for simultaneous detection of multiple respiratory pathogens
Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 49:2175-82. 2011
..The TLDA card approach offers promise for rapid and simultaneous identification of multiple respiratory pathogens for outbreak investigations and disease surveillance...