onychomycosis

Summary

Summary: A fungal infection of the nail plate, usually caused by a species of Epidermophyton, Microsporum, or Trichophyton, and producing opaque, white, thickened, friable, and brittle nails. (Dorland, 27th ed)

Top Publications

  1. ncbi Fungal thigmotropism in onychomycosis and in a clear hydrogel pad model
    G E Pierard
    Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    Dermatology 215:107-13. 2007
  2. ncbi Other fungi causing onychomycosis
    Gabriela Moreno
    Mycology Section, Department of Dermatology, Dr Manuel Gea Gonzalez General Hospital, Calzada de Tlalpan 4800, 14080 Mexico, DF, Mexico
    Clin Dermatol 28:160-3. 2010
  3. pmc Onychomycosis: pathogenesis, diagnosis, and management
    B E Elewski
    Department of Dermatology, University Hospitals of Cleveland, Case Western Reserve University, Ohio, USA
    Clin Microbiol Rev 11:415-29. 1998
  4. ncbi Onychomycosis--epidemiology, diagnosis and management
    R Kaur
    Department of Microbiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi 110 002, India
    Indian J Med Microbiol 26:108-16. 2008
  5. ncbi Onychomycosis: Clinico-mycologic study of 130 patients from Himachal Pradesh, India
    Mudita Gupta
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, India
    Indian J Dermatol Venereol Leprol 73:389-92. 2007
  6. ncbi Recent updates in oral terbinafine: its use in onychomycosis and tinea capitis in the US
    Lauren Van Duyn Graham
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Mycoses 54:e679-85. 2011
  7. ncbi Incidence of dermatophytosis in a public hospital of São Bernardo do Campo, São Paulo State, Brazil
    Andreia Pelegrini
    Núcleo de Pesquisas Biológicas, Universidade Metodista de São Paulo, Sao Bernardo do Campo, Sao Paulo, Brazil
    Rev Iberoam Micol 26:118-20. 2009
  8. ncbi Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Ontario, Canada
    Br J Dermatol 150:537-44. 2004
  9. ncbi Study of clinically suspected onychomycosis in a podiatric population
    Maureen B Jennings
    New York College of Podiatric Medicine, 1800 Park Ave, New York, NY 10035, USA
    J Am Podiatr Med Assoc 92:327-30. 2002
  10. ncbi Cutaneous infections dermatophytosis, onychomycosis, and tinea versicolor
    Melody R Vander Straten
    Department of Dermatology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USA
    Infect Dis Clin North Am 17:87-112. 2003

Detail Information

Publications311 found, 100 shown here

  1. ncbi Fungal thigmotropism in onychomycosis and in a clear hydrogel pad model
    G E Pierard
    Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    Dermatology 215:107-13. 2007
    ..This behavior has been shown experimentally with fungal hyphae of both dermatophytes and nondermatophyte molds, as well as with the mycelial phase of the dimorphic yeast Candida albicans...
  2. ncbi Other fungi causing onychomycosis
    Gabriela Moreno
    Mycology Section, Department of Dermatology, Dr Manuel Gea Gonzalez General Hospital, Calzada de Tlalpan 4800, 14080 Mexico, DF, Mexico
    Clin Dermatol 28:160-3. 2010
    Nondermatophyte onychomycosis account for 2% to 12% of all nail fungal infections and can be caused by a wide range of fungi, mainly Scopulariopsis brevicaulis, Aspergillus versicolor, A. flavus, A. niger, A...
  3. pmc Onychomycosis: pathogenesis, diagnosis, and management
    B E Elewski
    Department of Dermatology, University Hospitals of Cleveland, Case Western Reserve University, Ohio, USA
    Clin Microbiol Rev 11:415-29. 1998
    Although not life-threatening, onychomycosis (a fungal infection of the nail, usually caused by a dermatophyte) constitutes an important public health problem because of its high prevalence (about 10% of the U.S...
  4. ncbi Onychomycosis--epidemiology, diagnosis and management
    R Kaur
    Department of Microbiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi 110 002, India
    Indian J Med Microbiol 26:108-16. 2008
    b>Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts or nondermatophyte molds and represents about 30% of mycotic cutaneous infections...
  5. ncbi Onychomycosis: Clinico-mycologic study of 130 patients from Himachal Pradesh, India
    Mudita Gupta
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, India
    Indian J Dermatol Venereol Leprol 73:389-92. 2007
    b>Onychomycosis is a common nail infection caused by dermatophytes, yeast or other nondermatophyte molds and has diverse clinical presentations. Although common in this part of the country, no significant clinico-mycologic data is available.
  6. ncbi Recent updates in oral terbinafine: its use in onychomycosis and tinea capitis in the US
    Lauren Van Duyn Graham
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Mycoses 54:e679-85. 2011
    b>Onychomycosis and tinea capitis are prevalent fungal diseases that are difficult to cure and usually require systemic treatment. Onychomycosis has high recurrence rates and can significantly affect a patient's quality of life...
  7. ncbi Incidence of dermatophytosis in a public hospital of São Bernardo do Campo, São Paulo State, Brazil
    Andreia Pelegrini
    Núcleo de Pesquisas Biológicas, Universidade Metodista de São Paulo, Sao Bernardo do Campo, Sao Paulo, Brazil
    Rev Iberoam Micol 26:118-20. 2009
    ..6% of the infections. These data agree with findings reported in the literature indicating a lower prevalence of filamentous fungi, such as Epidermophyton, Trichophyton, and Microsporum, in dermatomycosis...
  8. ncbi Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Ontario, Canada
    Br J Dermatol 150:537-44. 2004
    b>Onychomycosis is a common nail disease that is often chronic, difficult to eradicate, and has a tendency to recur. The most common oral therapies for dermatophyte toenail onychomycosis include terbinafine, itraconazole and fluconazole.
  9. ncbi Study of clinically suspected onychomycosis in a podiatric population
    Maureen B Jennings
    New York College of Podiatric Medicine, 1800 Park Ave, New York, NY 10035, USA
    J Am Podiatr Med Assoc 92:327-30. 2002
    b>Onychomycosis, by definition, is a mycotic infection of the keratinized tissue of the nail plate...
  10. ncbi Cutaneous infections dermatophytosis, onychomycosis, and tinea versicolor
    Melody R Vander Straten
    Department of Dermatology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USA
    Infect Dis Clin North Am 17:87-112. 2003
    ..More research is needed to continue to develop drugs suitable for use in a broader range of patients and diagnostic tests that may be quicker or more specific than conventional ones...
  11. ncbi [Onychomycosis: clinical, epidemiological and mycological study in the municipality of São José do Rio Preto]
    Edna Alves Martins
    Laboratorio de Microbiologia, Faculdade de Medicina de Sao Jose do Rio Preto, Avenida Brigadeiro Faria Lima 5416, Sao Jose do Rio Preto, SP
    Rev Soc Bras Med Trop 40:596-8. 2007
    ..Candida parapsilosis (47%) and Trichophyton rubrum (38%) were prevalent. They were 100% sensitive to ketoconazole and 99% sensitive to amphotericin B. The highest prevalences were among women (80%), adults (62%) and toes (84%)...
  12. ncbi Onychomycosis in Iran: epidemiology, causative agents and clinical features
    Mohammad Reza Aghamirian
    Medical Parasitology and Mycology Department, Qazvin University of Medical Sciences and Health Services, Qazvin, Iran
    Nihon Ishinkin Gakkai Zasshi 51:23-9. 2010
    b>Onychomycosis represents the most frequently encountered nail disease, which is difficult to eradicate with drug treatment.
  13. ncbi Ciclopirox nail lacquer for the treatment of onychomycosis: an open non-comparative study
    Avner Shemer
    Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel
    J Dermatol 37:137-9. 2010
    b>Onychomycosis is a relatively common disease accounting for up to 50% of all nail disorders. Topical treatment, although less effective than systemic, is usually preferred by patients...
  14. ncbi Systematic review of nondermatophyte mold onychomycosis: diagnosis, clinical types, epidemiology, and treatment
    Aditya K Gupta
    University of Toronto, Toronto, Ontario, Canada
    J Am Acad Dermatol 66:494-502. 2012
    Nondermatophyte mold (NDM) onychomycosis is difficult to diagnose given that NDMs are common contaminants of the nails and of the mycology laboratory...
  15. ncbi Guidelines for treatment of onychomycosis
    D T Roberts
    Southern General Hospital, Glasgow G51 4TF, UK
    Br J Dermatol 148:402-10. 2003
    These guidelines for management of onychomycosis have been prepared for dermatologists on behalf of the British Association of Dermatologists...
  16. ncbi New therapeutic options for onychomycosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Expert Opin Pharmacother 13:1131-42. 2012
    b>Onychomycosis is a fungal infection of the nail apparatus that affects 10 - 30% of the global population...
  17. ncbi Onychomycosis: rationalization of topical treatment
    Avner Shemer
    Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:415-6. 2008
    ..Fungal infection of the nail affects millions of people worldwide and has an estimated prevalence of more than 10% of the general population...
  18. ncbi Phaeohyphomycosis and onychomycosis due to Chaetomium spp., including the first report of Chaetomium brasiliense infection
    Vit Hubka
    Department of Botany, Charles University in Prague, Czech Republic
    Med Mycol 49:724-33. 2011
    ..The second case involved onychomycosis with strikingly brown nail discoloration due to Chaetomium globosum in an otherwise healthy patient...
  19. ncbi Update in antifungal therapy of dermatophytosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center, Toronto, ON, Canada
    Mycopathologia 166:353-67. 2008
    ..For tinea unguium (onychomycosis) and tinea capitis, oral therapies are the primary treatments provided...
  20. ncbi Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis
    Stephen J Baker
    Anacor Pharmaceuticals Inc, 1060 East Meadow Circle, Palo Alto, California 94303, USA
    J Med Chem 49:4447-50. 2006
    A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-..
  21. ncbi Onychomycosis by molds. Report of 78 cases
    Alexandro Bonifaz
    Dermatology Service and Mycology Department, Hospital General de México OD, Sánchez Azcona 317 202, Col del Valle, CP 03020, Mexico D F
    Eur J Dermatol 17:70-2. 2007
    ..A total of 5,221 cases of onychomycosis were evaluated, 78 of which were molds (1.49%). Mean patient age was 44.1 years...
  22. ncbi Onychomycosis insensitive to systemic terbinafine and azole treatments reveals non-dermatophyte moulds as infectious agents
    Florence Baudraz-Rosselet
    Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Dermatology 220:164-8. 2010
    ..Dermatophytes are the main cause of onychomycoses, but various non-dermatophyte filamentous fungi are often isolated from abnormal nails...
  23. ncbi Novel treatment of onychomycosis using over-the-counter mentholated ointment: a clinical case series
    Richard Derby
    US Air Force 375th Medical Group, Family Medicine Residency Program, Belleville, IL, USA
    J Am Board Fam Med 24:69-74. 2011
    current medication treatments for onychomycosis have less than full cure-rate efficacy and have the potential for adverse side effects...
  24. ncbi Retrospective study of onychomycosis in Italy: 1985-2000
    Clara Romano
    Institute of Dermatological Sciences, University of Siena, Siena, Italy
    Mycoses 48:42-4. 2005
    Cases of onychomycosis diagnosed by mycological examination in three mycology units (Florence, Siena and Milan) of central and northern Italy over the 15-year period, 1985-2000, were studied retrospectively...
  25. ncbi Onychomycosis caused by Fusarium solani and Fusarium oxysporum in São Paulo, Brazil
    P Godoy
    Disciplina de Biologia Celular, Micologia, EPM UNIFESP, Sao Paulo, Brasil
    Mycopathologia 157:287-90. 2004
    ..We report eight cases of onychomycosis caused by Fusarium solani (4) and Fusarium oxysporum (4) in São Paulo, Brazil...
  26. ncbi Arthroconidia production in Trichophyton rubrum and a new ex vivo model of onychomycosis
    S Amir Yazdanparast
    Department of Microbiology, University of Leeds, Leeds LS2 9JT, UK
    J Med Microbiol 55:1577-81. 2006
    ..These in vitro and ex vivo results provide a useful basis for the understanding of arthroconidium formation in vivo in infected tissues such as nails...
  27. ncbi Toenail onychomycosis in diabetic patients: issues and management
    Peter Mayser
    Center of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
    Am J Clin Dermatol 10:211-20. 2009
    ..A recent large prospective study has shown that onychomycosis is among the most significant predictors of foot ulcer...
  28. ncbi Ciclopirox 8% nail lacquer topical solution for the treatment of onychomycosis in patients with diabetes: a multicenter, open-label study
    Marc A Brenner
    Institute for Diabetic Foot Research, Glendale, NY 11385, USA
    J Am Podiatr Med Assoc 97:195-202. 2007
    ..An open-label, noncomparative study was conducted to assess the safety and efficacy of ciclopirox 8% nail lacquer topical solution in patients with type 2 diabetes mellitus...
  29. ncbi A risk-benefit assessment of the newer oral antifungal agents used to treat onychomycosis
    A K Gupta
    Department of Medicine, Sunnybrook and Women s Health Sciences Center, University of Toronto Medical School, Canada
    Drug Saf 22:33-52. 2000
    The newer antifungal agents itraconazole, terbinafine and fluconazole have become available to treat onychomycosis over the last 10 years...
  30. ncbi Clinical and histological aspects of toenail onychomycosis caused by Aspergillus spp.: 34 cases treated with weekly intermittent terbinafine
    Claudia Gianni
    Department of Dermatology, Scientific Institute, S Raffaele Hospital, Milan, Italy
    Dermatology 209:104-10. 2004
    ..Epidemiological studies have shown that Aspergillus spp. are emerging fungal agents of toenail onychomycosis. Indeed, after Scopulariopsis spp...
  31. ncbi Non-dermatophyte onychomycosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, Toronto, Canada
    Dermatol Clin 21:257-68. 2003
    Non-dermatophyte organisms are becoming increasingly prevalent in onychomycosis. This apparent emergence might be an artifact of improved diagnostic techniques and increased awareness that these fungi are potential etiologic agents...
  32. ncbi Toenail onychomycosis: an important global disease burden
    J Thomas
    School of Pharmacy, University of Tasmania, Tasmania Department of Podiatry, Royal Hobart Hospital, Hobart, Tasmania, Australia
    J Clin Pharm Ther 35:497-519. 2010
    b>Onychomycosis is a fungal infection of the nail plate or nail bed. It does not usually cure itself and it can trigger more infectious lesions in other parts of the body...
  33. ncbi Sensitivity of fungi isolated from onychomycosis to Eugenia cariophyllata essential oil and eugenol
    C W Gayoso
    Department of Health Promotion, Health Science Center, Federal University of Paraiba, Joao Pessoa, Brazil
    Fitoterapia 76:247-9. 2005
    ..of Eugenia cariophyllata essential oil and eugenol, its major constituent, on fungal strains isolated from onychomycosis was evaluated. The natural products presented prominent antifungal action with MIC of 1% and 4%, respectively.
  34. ncbi Topical antifungal drugs for the treatment of onychomycosis: an overview of current strategies for monotherapy and combination therapy
    R Baran
    Nail Disease Center, 42, rue des Serbes, 06400 Cannes, France
    J Eur Acad Dermatol Venereol 19:21-9. 2005
    b>Onychomycosis is a relatively common disease accounting for up to 50% of all nail disorders and its prevalence rises with age...
  35. ncbi Successive mycological nail tests for onychomycosis: a strategy to improve diagnosis efficiency
    Tereza Elizabeth Fernandes Meireles
    Medical Micology Specialized Center, Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil
    Braz J Infect Dis 12:333-7. 2008
    b>Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts and moulds, accounting for about 50% of onychopathies...
  36. ncbi The diagnosis of onychomycosis in a geriatric population: a study of 450 cases in South Florida
    W P Scherer
    Barry University School of Graduate Medical Sciences, Miami Shores, FL, USA
    J Am Podiatr Med Assoc 91:456-64. 2001
    An investigative study was performed to determine the diagnosis of onychomycosis in a South Florida geriatric population...
  37. ncbi Onychomycosis in central India: a clinicoetiologic correlation
    Amit Garg
    Post Graduate Department of Microbiology, King George s Medical College, CSM Medical University, Lucknow, India
    Int J Dermatol 43:498-502. 2004
    b>Onychomycosis is mainly caused by dermatophytes, but yeasts and nondermatophyte molds have also been implicated, giving rise to diverse clinical presentations. The etiological agents of the disease may show geographic variation...
  38. ncbi Onychomycosis in Northern Greece during 1994-1998
    T Koussidou
    Mycological Laboratory, State Hospital, Thessaloniki, Greece
    Mycoses 45:29-37. 2002
    ..6%) and yeasts (2%); 16.1% of the infections were mixed. In the fingernail infections mostly yeasts were isolated (72%), especially in women, followed by dermatophytes (10%) and moulds (5.6%); 12.4% of the infections were mixed...
  39. ncbi New criteria for the laboratory diagnosis of nondermatophyte moulds in onychomycosis
    A Shemer
    Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel
    Br J Dermatol 160:37-9. 2009
    Nondermatophyte moulds (NDM) may be found as aetiological agents or as contaminants in onychomycosis. The classic and most used criteria for the diagnosis of NDM are those established by English in 1976.
  40. ncbi Fungal infection of the feet in soccer players and non-athlete individuals
    Katia Sheylla Malta Purim
    Mycology Laboratory, Federal University of Parana, Brazil
    Rev Iberoam Micol 22:34-8. 2005
    ..None of the Chinese athletes had tinea pedis alone. However, in this group onychomycosis was frequently higher when compared to the other groups...
  41. ncbi Superficial fungal infections: an update on pityriasis versicolor, seborrheic dermatitis, tinea capitis, and onychomycosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Ontario, Canada
    Clin Dermatol 21:417-25. 2003
    The recent advances in pityriasis versicolor, seborrheic dermatitis, tinea capitis and onychomycosis are reviewed...
  42. ncbi Onychomycosis in clinical practice: factors contributing to recurrence
    R K Scher
    Dermatology Department, College of Physicians and Surgeons of Columbia University, New York, USA
    Br J Dermatol 149:5-9. 2003
    The treatment of onychomycosis has improved in recent years and many patients can now expect a complete and lasting cure...
  43. ncbi Onychomycosis in Lebanon: a mycological survey of 772 patients
    Fouad El Sayed
    Division of Dermatology, Faculty of Medicine, Lebanese University, Beirut, Lebanon
    Mycoses 49:216-9. 2006
    Accurate diagnosis of onychomycosis is based on clinical findings, direct microscopic investigation and mycological culture...
  44. pmc Ultraviolet C inactivation of dermatophytes: implications for treatment of onychomycosis
    T Dai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Br J Dermatol 158:1239-46. 2008
    b>Onychomycosis responds to systemic antifungals and sometimes to topical lacquers, but alternative treatments are desirable...
  45. ncbi A comparative study of KOH test, PAS staining and fungal culture in diagnosis of onychomycosis in Taiwan
    Yu Ping Hsiao
    J Dermatol Sci 45:138-40. 2007
  46. ncbi Onychomycosis caused by an isolate conforming to the description of Trichophyton raubitschekii
    Manuela Papini
    Perugia University, Terni Dermatological Clinic, Terni, Italy
    Med Mycol 42:273-6. 2004
    ..tropical and subtropical countries, and are mainly obtained from upper body skin infections, rarely from onychomycosis. In this paper the authors report the first known Italian case of onychomycosis caused by such an isolate...
  47. ncbi Onychomycosis in Malaysia
    K P Ng
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Mycopathologia 147:29-32. 1999
    The common etiological agents of onychomycosis are dermatophytes, molds and yeasts...
  48. ncbi Isolation of Fusarium sp. from a claw of a dog with onychomycosis
    Kazuko Namitome
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Vet Med Sci 73:965-9. 2011
    ..To the authors' knowledge, this is the first case report of canine onychomycosis in which Fusarium sp. was isolated from the affected claw.
  49. ncbi The use of high frequency waves to treat onychomycosis: preliminary communication of three cases
    Juliana Leal Monteiro da Silva
    University Center of Araraquara and Private Clinic Sao Paulo SP, Brazil
    An Bras Dermatol 86:598-600. 2011
    The research evaluated the efficacy of high frequency waves in the treatment of onychomycosis in three patients during twelve months through the clinical examination of nails and also through mycological examination...
  50. ncbi Onychomycosis: current treatment and future challenges
    D T Roberts
    Department of Dermatology, Southern General Hospital, Glasgow, UK
    Br J Dermatol 141:1-4. 1999
    b>Onychomycosis is a fungal infection of the nails, more often of the toenails. It is a common condition, with an estimated overall prevalence of 3-10% in European populations...
  51. ncbi Ciclopirox 8% nail lacquer in the treatment of onychomycosis of the toenails in the United States
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, Toronto, Ontario, Canada
    J Am Podiatr Med Assoc 90:495-501. 2000
    ..the first topical antifungal agent to be approved by the US Food and Drug Administration for the treatment of onychomycosis. This article reviews the results of the two pivotal clinical trials of this drug that have been performed in ..
  52. ncbi Cutaneous malasseziasis: four case reports of atypical dermatitis and onychomycosis caused by Malassezia
    Ying Zhao
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China
    Int J Dermatol 49:141-5. 2010
    ..This study investigates four special cases associated with Malassezia...
  53. ncbi Therapeutic efficacy of topical OLEOZON® in patients suffering from onychomycosis
    Silvia Menendez
    Ozone Research Center, National Center for Scientific Research, Havana, Cuba
    Mycoses 54:e272-7. 2011
    The results of the use of ozonised sunflower oil (OLEOZON(®)) in the treatment of onychomycosis, based on its known antimycotic action and good skin tolerance, by means of a controlled randomised phase III assay are presented...
  54. ncbi Onycomychosis due to Scytalidium spp.: a clinical and epidemiologic study at a University Hospital in Rio de Janeiro, Brazil
    Igor Brum Cursi
    Pedro Ernesto University Hospital, State University of Rio de Janeiro, Brasil
    An Bras Dermatol 86:689-93. 2011
    ..It is currently considered a primary pathogen of the nail. The prevalence of nail infections caused by this fungus has been increasing in recent decades, although few published studies have been done on its epidemiology...
  55. ncbi Onychomycosis and tinea pedis in athletes from the State of Rio Grande Do Sul (Brazil): a cross-sectional study
    Clarice Saggin Sabadin
    Department of Dermatology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Mycopathologia 171:183-9. 2011
    b>Onychomycosis and tinea pedis are common superficial infections caused primarily by dermatophytes...
  56. ncbi Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis - comparison of six diagnostic methods
    G Rothmund
    Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, Germany
    Mycoses 56:47-55. 2013
    b>Onychomycosis is common and can mimic several different nail disorders. Accurate diagnosis is essential to choose the optimum antifungal therapy...
  57. ncbi Non-dermatophyte moulds as pathogens of onychomycosis
    Umme Farwa
    Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi
    J Coll Physicians Surg Pak 21:597-600. 2011
    To determine the role and pattern of non-dermatophyte moulds as causative agents of onychomycosis.
  58. ncbi A new classification system for grading the severity of onychomycosis: Onychomycosis Severity Index
    Caitlin Carney
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Arch Dermatol 147:1277-82. 2011
    To establish and validate a new system to define the severity of onychomycosis. The Onychomycosis Severity Index (OSI) score is obtained by multiplying the score for the area of involvement (range, 0-5) by the score for the proximity of ..
  59. pmc Utility of inoculum counting (Walshe and English criteria) in clinical diagnosis of onychomycosis caused by nondermatophytic filamentous fungi
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Womens College Health Sciences Center, Sunnybrook, Ontario, Canada
    J Clin Microbiol 39:2115-21. 2001
    Opportunistic onychomycosis caused by nondermatophytic molds may differ in treatment from tinea unguium...
  60. ncbi Concordance between direct microscopy and fungical culture for the diagnostic of feet's onychomycosis
    Paulo Ricardo Martins Souza
    Dermatology Services, Santa Casa de Misericordia de Porto Alegre, Brazil
    An Bras Dermatol 87:157-9. 2012
    ..microscopy and fungical culture from subungueal samples of the patients with clinical suspicion of feet's onychomycosis. The agreement occurred in 56.1% of the exams with dermatophytes, in 52.4% by others fungi and in 90...
  61. ncbi Prognostic factors for cure following treatment of onychomycosis
    B Sigurgeirsson
    Department of Dermatology, University of Iceland, Reykjavik, Iceland
    J Eur Acad Dermatol Venereol 24:679-84. 2010
    To examine if host baseline factors and week 24 mycology results are associated with mycological and clinical cure in patients with onychomycosis treated with oral terbinafine.
  62. pmc Establishment of a novel model of onychomycosis in rabbits for evaluation of antifungal agents
    Tsuyoshi Shimamura
    R and D Laboratories, Pola Pharma Inc, 560 Kashio cho, Totsuka ku, Yokohama 244 0812, Japan
    Antimicrob Agents Chemother 55:3150-5. 2011
    We developed a novel model of onychomycosis in which we observed fungi in the deep layer of the nail, and we used the model to evaluate the efficacy of two topical antifungal drugs...
  63. ncbi A randomized, placebo- and active-controlled, parallel-group, multicentre, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis
    B Elewski
    University of Alabama, Birmingham, AL, U S A Endeavor Clinical Trials PA, San Antonio, TX, USA
    Br J Dermatol 166:389-98. 2012
    b>Onychomycosis accounts for up to 50% of all onychopathies.
  64. ncbi Clinical diagnosis of toenail onychomycosis is possible in some patients: cross-sectional diagnostic study and development of a diagnostic rule
    I Garcia-Doval
    Department of Dermatology, Complexo Hospitalario de Pontevedra, SERGAS, LoureiroCrespo, 2, Pontevedra 36001, Spain
    Br J Dermatol 163:743-51. 2010
    Suspected toenail onychomycosis is a frequent problem. Clinical diagnosis has been considered inadequate.
  65. ncbi Malassezia furfur in a case of onychomycosis: colonizer or etiologic agent?
    Anuradha Chowdhary
    Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Med Mycol 43:87-90. 2005
    The etiologic role of Malassezia furfur in onychomycosis is a contentious diagnostic problem because its keratinolytic ability has never been verified. This case report describes the isolation of M...
  66. ncbi Clinical evaluation of safety and efficacy of a new topical treatment for onychomycosis
    Adnan Nasir
    Wake Research Associates, LLC, Raleigh, NC, USA
    J Drugs Dermatol 10:1186-91. 2011
    This clinical study assessed the safety and efficacy of an investigational topical product for the treatment of onychomycosis (nail fungus).
  67. ncbi Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox
    Ofelia Romero-Cerecero
    Centro de Investigacion Biomedica del Sur, Instituto Mexicano del Seguro Social IMSS, Morelos, Mexico
    Planta Med 74:1430-5. 2008
    ..b>Onychomycosis, also known as tinea of the nails or tinea unguium, constitutes an infection of the nails produced by ..
  68. ncbi Onychomycosis
    Oliverio Welsh
    Department of Dermatology, Dr Jose Eleuterio Gonzalez University Hospital, Avenida Francisco I Madero y Avenida Gonzalitos s n, Colonia Mitras Centro, Monterrey, Nuevo Leon 64460, Mexico
    Clin Dermatol 28:151-9. 2010
    b>Onychomycosis is a frequent nail disease caused by dermatophytes, yeasts, and nondermatophyte molds. Trichophyton rubrum, T mentagrophytes, and Epidermophyton floccosum are the most common etiologic agents worldwide...
  69. ncbi The diagnosis of nondermatophyte mold onychomycosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, Toronto, Ont, Canada
    Int J Dermatol 42:272-3. 2003
  70. ncbi Onychomycosis in inflammatory bowel diseases
    D Gaburri
    Department of Medicine, Division of Gastroenterology and Dermatology, Inflammatory Bowel Diseases Center, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine, Minas Gerais, Brazil
    J Eur Acad Dermatol Venereol 22:807-12. 2008
    As far as we have sought for in Medline and PubMed, not one study until now has evaluated the prevalence of onychomycosis in patients with inflammatory bowel disease (IBD)...
  71. ncbi Identification, antifungal susceptibility and scanning electron microscopy of a keratinolytic strain of Rhodotorula mucilaginosa: a primary causative agent of onychomycosis
    Marcel M L da Cunha
    Laboratório de Biologia Celular de Fungos, Instituto de Biofisica Carlos Chagas Filho UFRJ, Cidade Universitaria, Rio de Janeiro, Brazil
    FEMS Immunol Med Microbiol 55:396-403. 2009
    b>Onychomycosis is a dermatological problem of high prevalence that mainly affects the hallux toenail...
  72. ncbi A rationale for systemic treatment in onychomycosis with negative results on fungal examination
    B Amichai
    Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel
    Clin Exp Dermatol 36:724-7. 2011
    ..Laboratory confirmation of fungal infection is currently accepted as a requirement before initiation of antifungal treatment in clinical practice...
  73. ncbi Treating onychomycosis
    P Rodgers
    University of Michigan Medical School, Ann Arbor, USA
    Am Fam Physician 63:663-72, 677-8. 2001
    b>Onychomycosis accounts for one third of fungal skin infections...
  74. doi Onychomycosis caused by Phaeoacremonium parasiticum: first case report
    Pei Lun Sun
    Mycoses 54:172-4. 2011
    A variety of non-dermatophyte moulds can cause human onychomycosis. We report an unusual case of onychomycosis caused by Phaeoacremonium parasiticum, which has not been mentioned in the literature before...
  75. ncbi Influence of human nail etching for the assessment of topical onychomycosis therapies
    Michael A Repka
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677 1848, USA
    Int J Pharm 282:95-106. 2004
    ..the influence of 'nail etching' on film bioadhesion and drug permeability for the assessment of topical onychomycosis therapies. Hot-melt extrusion (HME) was used to prepare films containing 20% w/w ketoconazole. Ketoconazole 0...
  76. ncbi Laser treatment of onychomycosis using a novel 0.65-millisecond pulsed Nd:YAG 1064-nm laser
    Lisa G Hochman
    Morristown Dermatology, 290 Madison Avenue, Morristown, 07960, USA
    J Cosmet Laser Ther 13:2-5. 2011
    b>Onychomycosis is a common disorder of the nails. Treatment modalities include oral and topical antifungals, surgical treatment or a combination of these therapies...
  77. ncbi Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years
    B Sigurgeirsson
    Dermatology Center, Kopavogur, Iceland
    J Eur Acad Dermatol Venereol 24:910-5. 2010
    Standard treatment for onychomycosis often results in less than half of subjects achieving disease-free nails. Onychomycosis is even more challenging to treat as relapses and re-infections are common.
  78. ncbi Management of onychomycosis and awareness of guidelines among dermatologists
    S F Rajpar
    Br J Dermatol 155:1080-2. 2006
  79. ncbi Onychomycosis therapy: past, present, future
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Canada
    J Drugs Dermatol 9:1109-13. 2010
    Methods to treat onychomycosis are varied, using therapies that can be categorized as topical, oral or device-related. Since their development, oral therapies have represented the gold standard for treatment over other methods...
  80. ncbi Successful treatment of onychomycosis with fluconazole in two patients with hyperimmunoglobulin E syndrome
    Y Aihara
    Department of Pediatrics, Yokohama City University, School of Medicine, Japan
    Pediatr Dermatol 13:493-5. 1996
    We report two patients with hyperimmunoglobulin E syndrome who had fingernail onychomycosis and were successfully treated with fluconazole...
  81. ncbi Onychomycosis in Tehran, Iran: prevailing fungi and treatment with itraconazole
    A R Khosravi
    Department of Medical Mycology, Faculty of Veterinary Medicine, Tehran, Iran
    Mycopathologia 150:9-13. 2001
    A total of 187 Patients with suspected onychomycosis were examined for causative fungal agents between 1996 and 1997...
  82. ncbi Onychomycosis caused by Fusarium sp in Sri Lanka: prevalence, clinical features and response to itraconazole pulse therapy in six cases
    Ranthilaka R Ranawaka
    Teaching Hospital Karapitiya, Galle, Sri Lanka
    J Dermatolog Treat 19:308-12. 2008
    The aims of our study were to ascertain the proportion of Fusarium onychomycosis among patients with suspected onychomycosis, to record clinical features and to assess the efficacy of itraconazole pulse therapy in treatment.
  83. ncbi Novel topical formulations of Terbinafine-HCl for treatment of onychomycosis
    Sakine Tuncay Tanrıverdi
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey Electronic address
    Eur J Pharm Sci 48:628-36. 2013
    Terbinafine hydrochloride (TBF-HCl) is an active substance that is using for treatment of onychomycosis. Onychomycosis is a fungal infection which is the most common disease of nail plate...
  84. ncbi Evaluation of a polymerase chain reaction-restriction fragment length polymorphism assay for dermatophyte and nondermatophyte identification in onychomycosis
    O Bontems
    Department of Dermatology, Laboratoire de Mycologie, BT422, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Br J Dermatol 161:791-6. 2009
    ..The correct identification of the aetiological agent of nail infections is necessary in order to recommend appropriate treatment...
  85. ncbi Efficacy of debridement alone versus debridement combined with topical antifungal nail lacquer for the treatment of pedal onychomycosis: a randomized, controlled trial
    D Scot Malay
    Penn Presbyterian Medical Center, Philadelphia, PA, USA
    J Foot Ankle Surg 48:294-308. 2009
    Pedal onychomycosis is a common malady caused by dermatophytes, saprophytes, and yeasts...
  86. ncbi Treatment of mild, moderate, and severe onychomycosis using 870- and 930-nm light exposure
    Adam S Landsman
    Division of Podiatric Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Am Podiatr Med Assoc 100:166-77. 2010
    The Noveon is a unique dual-wavelength near-infrared diode laser used to treat onychomycosis. The device operates at physiologic temperatures that are thermally safe for human tissue...
  87. ncbi Epidemiology of onychomycosis in patients with diabetes mellitus in India
    Sunil Dogra
    Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Dermatol 41:647-51. 2002
    The number of individuals diagnosed with diabetes mellitus is increasing worldwide. Although onychomycosis is often observed in diabetics, there have been no large studies of its epidemiology in this patient group in India.
  88. ncbi Study of onychomycosis: prevailing fungi and pattern of infection
    P Veer
    Department of Microbiology, Government Medical College, Aurangabad, Maharashtra, India
    Indian J Med Microbiol 25:53-6. 2007
    A mycological study of onychomycosis was undertaken in 88 patients. The nails were judged to be infected by their clinical appearance. Direct microscopy of the nail clips in 20% KOH solution was positive in 72 (81...
  89. ncbi First Spanish case of onychomycosis caused by Chaetomium globosum
    Carmen Aspiroz
    Microbiologia, Hospital Royo Villanova, Zaragoza, Spain
    Med Mycol 45:279-82. 2007
    ..To our knowledge, there have been only five credible descriptions of onychomycosis caused by members of this genus and only two of these contained information on therapy...
  90. ncbi Molecular strain typing of Trichophyton rubrum indicates multiple strain involvement in onychomycosis
    A Yazdanparast
    Iran University of Medical Sciences and Health Sciences, PO Box 15875 6171, Tehran, Iran
    Br J Dermatol 148:51-4. 2003
    Trichophyton rubrum is an important cause of onychomycosis. Molecular strain typing methods have recently been developed to address questions of epidemiology and source of relapse following treatment.
  91. ncbi Review of antifungal therapy, part II: treatment rationale, including specific patient populations
    Robert Baran
    Nail Disease Centre, Cannes, France
    J Dermatolog Treat 19:168-75. 2008
    ..Prevalence of onychomycosis is high in immunocompromised patients with higher relapse rates after treatment...
  92. ncbi Bioadhesive patch-based delivery of 5-aminolevulinic acid to the nail for photodynamic therapy of onychomycosis
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    J Control Release 103:381-92. 2005
    ..ALA could be achieved within the nail matrix, and at the nail bed, PDT may prove to be a useful treatment for onychomycosis. Patch application for 24 h allowed an ALA concentration of 2...
  93. ncbi Study of onychomycosis in Isfahan, Iran
    Mostafa Chadeganipour
    Mycology and Parasitology Department, Isfahan Medical School, Isfahan University of Medical Sciences, Iran
    Mycoses 53:153-7. 2010
    A mycological study was undertaken in 488 patients suspected of onychomycosis in Isfahan, a large province of Iran, to gain more insight into the prevalence and aetiology of this infection...
  94. ncbi Characterization of hot-melt extruded drug delivery systems for onychomycosis
    Praveen K Mididoddi
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, USA
    Eur J Pharm Biopharm 66:95-105. 2007
    ..of this investigation were to study the physico-chemical properties of hot-melt extruded (HME) films for onychomycosis and to determine the stability of the model antifungal drug incorporated within these films...
  95. ncbi Epidemiological and aetiological study on tinea pedis and onychomycosis in Algeria
    Assya Djeridane
    Service de Dermatologie, Hôpital Central de l Armée, Kouba, Algiers, Algeria
    Mycoses 49:190-6. 2006
    Epidemiological studies on tinea pedis and onychomycosis, common fungal infections, have been conducted in many parts of the world. There are currently no studies of tinea pedis and/or onychomycosis in Algeria...
  96. ncbi In vitro antifungal oral drug and drug-combination activity against onychomycosis causative dermatophytes
    D A Santos
    Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Med Mycol 44:357-62. 2006
    ..All test strains were recovered from patients with toe nail onychomycosis and the minimum inhibitory concentration (MIC) of each antifungal against both species was individually ..
  97. ncbi Onychomycosis in children: treatment with bifonazole-urea
    A Bonifaz
    Mycology Department, Dermatology Service, Hospital General de Mexico, and Pediatric Dermatology Service, Hospital Infantil de Mexico, Mexico City, Mexico
    Pediatr Dermatol 17:310-4. 2000
    ..the safety and efficacy of a two-phase topical treatment with bifonazole-urea ointment in children with onychomycosis. Twenty-five children younger than 16 years old with proved onychomycosis were included in the study...
  98. ncbi Onychomycosis: strategies to reduce failure and recurrence
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center, Ontario, Canada
    Cutis 62:189-91. 1998
    Many patients with onychomycosis of the toes respond satisfactorily to standard treatment regimens using the newer antifungal agents terbinafine and itraconazole...
  99. ncbi Epidemiological survey of foot diseases in Japan: results of 30,000 foot checks by dermatologists
    Shinichi Watanabe
    Department of Dermatology, Teikyo University School of Medicine, Itabashi, Tokyo, Japan
    J Dermatol 37:397-406. 2010
    ..2% used topical medication only. This survey showed that often patients are not aware of fungal infections and that their treatment is sometimes insufficient. Dermatologists should actively examine and treat patients with TP and TU...
  100. ncbi Onychomycosis: a critical study of techniques and criteria for confirming the etiologic significance of nondermatophytes
    Richard C Summerbell
    Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands
    Med Mycol 43:39-59. 2005
    ..2% of NDF infections were found to be associated with a concurrent dermatophytosis. In auxiliary studies, some nails remained NDF-infected after dermatophytes had been successfully eliminated by therapy...
  101. ncbi Direct antifungal effect of femtosecond laser on Trichophyton rubrum onychomycosis
    Zakhariya Manevitch
    Department of Applied Physics, Selim and Rachel Benin School of Engineering and Computer Science, The Hebrew University, Jerusalem, Israel
    Photochem Photobiol 86:476-9. 2010
    b>Onychomycosis is caused by dermatophyte infection of the nail...

Research Grants16

  1. Iontophoresis to Improve Nail Disease Treatment
    KEVIN S LI; Fiscal Year: 2012
    It is estimated that approximately 30 million Americans are infected by onychomycosis. The current method of treatment for onychomycosis is oral systemic administration of antifungal agents, which has long treatment regimen and is not ..
  2. Electropulsation mediated drug therapy for Onychomycosis
    SATHYANARAYANA MURTHY; Fiscal Year: 2009
    ..Topical monotherapy is "less successful" in treating onychomycosis due to poor trans-nail permeation of antifungal drugs...
  3. Ultraviolet-C Therapy for Onychomycosis
    MICHAEL HAMBLIN; Fiscal Year: 2006
    ..by applicant): Keraderm LLC and the Wellman Center for Phototherapy propose a radically new treatment for onychomycosis using germicidal radiation instead of current medications which have significant drawbacks...
  4. Development of a New Topical Antifungal Agent
    Sheldon Pinnell; Fiscal Year: 2006
    ..will be conducted to determine the effectiveness of the antifungal chemical as a topical treatment for toenail onychomycosis due to dermatophyte infection...
  5. Differences in CAM Use Among Minority Older Adults
    Thomas Arcury; Fiscal Year: 2005
    ..abstract_text> ..
  6. Community-Based Participatory Approach to Farmworker Housing, Exposures & Health
    Thomas A Arcury; Fiscal Year: 2010
    ....
  7. Farmwoker Environmental Health Research Comparable Data
    Thomas Arcury; Fiscal Year: 2004
    ..The purpose of limiting the size of the conference is to facilitate active interaction, discussion and debate among leaders in the field. ..
  8. Casa A Campo: Pesticide Safety for Farmworkers' Families
    Thomas Arcury; Fiscal Year: 2004
    ....
  9. Ethnic Variation in CAM Use and Health Self Management among Rural Older Adults
    Thomas Arcury; Fiscal Year: 2009
    ....
  10. African American Men Prostate & Colorectal Cancer Belief
    Thomas Arcury; Fiscal Year: 2007
    ..A preliminary framework of the intervention strategy for this R01 application will be developed and evaluated as part of this project. [unreadable] [unreadable]..
  11. RURAL ELDERS: ETHNICITY, FOOD MEANING & DIET MEASUREMENT
    SARA QUANDT; Fiscal Year: 2004
    ..These participants will complete six 24 hour diet recall interviews over a six month period, which will be used to validate the adapted Food Frequency Questionnaire and Meal Pattern Questionnaire. ..
  12. JUSTA: Justice and Health for Poultry Workers
    SARA QUANDT; Fiscal Year: 2008
    ..abstract_text> ..
  13. Rural Elders' Diabetes Self Management: Development of a Common Sense Model Inven
    Sara A Quandt; Fiscal Year: 2010
    ....
  14. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..Further we also plan to correlate the time course of unbound ciprofloxacin in dermal ECF with that in synovial fluid determined by microdialysis in rat. [unreadable] [unreadable] [unreadable]..
  15. Local Angiogenic Therapy for Diabetic Ulcers
    Harold Brem; Fiscal Year: 2006
    ..Support from this proposal will allow the applicant to use knowledge from the fields of gene therapy, angiogenesis and wound healing to develop a safe angiogenic gene therapy for diabetic foot ulcers. ..
  16. Local Angiogenic Gene Therapy/VEGF/Treat Diabetic Ulcers
    Harold Brem; Fiscal Year: 2003
    ..In addition, we will analyze the wound fluid in order to determine the temporal expression of VEGF in a diabetic ulcer. ..