rosacea

Summary

Summary: A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).

Top Publications

  1. ncbi Rosacea: I. Etiology, pathogenesis, and subtype classification
    Glen H Crawford
    Department of Dermatology, University of Pennsylvania Medical Center, USA
    J Am Acad Dermatol 51:327-41; quiz 342-4. 2004
  2. ncbi Therapeutic response of rosacea to dobesilate
    Pedro Cuevas
    Department of Research, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Med Res 10:454-6. 2005
  3. ncbi Mite-related bacterial antigens stimulate inflammatory cells in rosacea
    N Lacey
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Br J Dermatol 157:474-81. 2007
  4. ncbi Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea
    S Georgala
    National University of Athens, Department of Dermatology and Venereology, A. Sygros' Hospital, Greece
    J Eur Acad Dermatol Venereol 15:441-4. 2001
  5. pmc The molecular pathology of rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, CA 92161, USA
    J Dermatol Sci 55:77-81. 2009
  6. ncbi Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea
    J J Wu
    Department of Dermatology, University of California, Irvine, Irvine, CA 92697 2400, USA
    Clin Exp Dermatol 32:693-5. 2007
  7. ncbi Clinical practice. Rosacea
    Frank C Powell
    Regional Centre of Dermatology, Mater Misericordiae Hospital, Dublin, Ireland
    N Engl J Med 352:793-803. 2005
  8. ncbi Recently approved systemic therapies for acne vulgaris and rosacea
    James Q Del Rosso
    University of Nevada School of Medicine, Las Vegas, USA
    Cutis 80:113-20. 2007
  9. ncbi Papulopustular rosacea: prevalence and relationship to photodamage
    Maeve A McAleer
    Regional Center of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland
    J Am Acad Dermatol 63:33-9. 2010
  10. ncbi [Concentration of selected cytokines in serum of patients with acne rosacea]
    Małgorzata Salamon
    Katedra i Klinika Dermatologii i Wenerologii, Uniwersytetu Medycznego w Łodzi
    Przegl Lek 65:371-4. 2008

Detail Information

Publications269 found, 100 shown here

  1. ncbi Rosacea: I. Etiology, pathogenesis, and subtype classification
    Glen H Crawford
    Department of Dermatology, University of Pennsylvania Medical Center, USA
    J Am Acad Dermatol 51:327-41; quiz 342-4. 2004
    b>Rosacea is one of the most common conditions dermatologists treat. Rosacea is most often characterized by transient or persistent central facial erythema, visible blood vessels, and often papules and pustules...
  2. ncbi Therapeutic response of rosacea to dobesilate
    Pedro Cuevas
    Department of Research, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Med Res 10:454-6. 2005
    Despite an incomplete understanding of the pathogenesis of rosacea, therapeutic modalities continue to expand...
  3. ncbi Mite-related bacterial antigens stimulate inflammatory cells in rosacea
    N Lacey
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Br J Dermatol 157:474-81. 2007
    Patients with papulopustular rosacea have a higher density of Demodex folliculorum mites on their faces than normal subjects but the role, if any, of their mites in initiating inflammation is disputed...
  4. ncbi Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea
    S Georgala
    National University of Athens, Department of Dermatology and Venereology, A. Sygros' Hospital, Greece
    J Eur Acad Dermatol Venereol 15:441-4. 2001
    BACKGROUND: Rosacea is a common chronic dermatosis that evolves in stages. The mite Demodex folliculorum has been implicated in its obscure aetiopathogenesis. AIM: To evaluate the importance of D...
  5. pmc The molecular pathology of rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, CA 92161, USA
    J Dermatol Sci 55:77-81. 2009
    b>Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all related by the presence of chronic facial skin inflammation...
  6. ncbi Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea
    J J Wu
    Department of Dermatology, University of California, Irvine, Irvine, CA 92697 2400, USA
    Clin Exp Dermatol 32:693-5. 2007
    Many patients with rosacea are unable to tolerate extended treatment periods with topical agents because of the unusually high skin sensitivity that often accompanies rosacea...
  7. ncbi Clinical practice. Rosacea
    Frank C Powell
    Regional Centre of Dermatology, Mater Misericordiae Hospital, Dublin, Ireland
    N Engl J Med 352:793-803. 2005
  8. ncbi Recently approved systemic therapies for acne vulgaris and rosacea
    James Q Del Rosso
    University of Nevada School of Medicine, Las Vegas, USA
    Cutis 80:113-20. 2007
    ..oral isotretinoin for the treatment of severe recalcitrant nodular acne, systemic therapy for acne vulgaris and rosacea has been based on anecdotal support, clinical experience, and small clinical trials...
  9. ncbi Papulopustular rosacea: prevalence and relationship to photodamage
    Maeve A McAleer
    Regional Center of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland
    J Am Acad Dermatol 63:33-9. 2010
    The prevalence and pathogenesis of rosacea is uncertain. Previously, studies used varying definitions of disease and have not explored the relationship of its prevalence to ultraviolet (UV) exposure or photodamage.
  10. ncbi [Concentration of selected cytokines in serum of patients with acne rosacea]
    Małgorzata Salamon
    Katedra i Klinika Dermatologii i Wenerologii, Uniwersytetu Medycznego w Łodzi
    Przegl Lek 65:371-4. 2008
    b>Rosacea is a common chronic disorder, mainly affects women in their thirties or fourties. As etiology, inflammation is taken into consideration.
  11. ncbi Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:11-7. 2004
    ..efficacy of topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) versus vehicle in the treatment of rosacea. The objective was to compare the baseline and end-of-treatment photographs of patients treated with BP/C versus ..
  12. ncbi Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea
    Jonathan Wilkin
    Division of Dermatologic and Dental Drug Products, Food and Drug Administration, Rochville, Maryland, USA
    J Am Acad Dermatol 50:907-12. 2004
  13. ncbi The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol
    F Grønhøj Larsen
    Department of Dermatology, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
    Br J Dermatol 161:664-70. 2009
    Isotretinoin is effective in the treatment of severe acne and rosacea. Both parent drug and its main metabolite 4-oxo-isotretinoin are potentially teratogenic compounds and contain a carboxylic acid moiety...
  14. ncbi Comparison of tear function tests and impression cytology with the ocular findings in acne rosacea
    V Yaylali
    Department of Ophthalmology, Pamukkale University School of Medicine, Denizli, Turkey
    Eur J Ophthalmol 12:11-7. 2002
    The aim of this study was to determine the correlation between tear function tests and impression cytology results and the clinical findings in ocular rosacea.
  15. ncbi Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results
    P Papageorgiou
    Department of Dermatology, Royal Free Hampstead NHS Trust, London NW3 2QG, UK
    Br J Dermatol 159:628-32. 2008
    b>Rosacea is a common skin condition but the treatments currently available are not satisfactory.
  16. ncbi Rhinophyma: review and update
    Rod J Rohrich
    Division of Plastic and Reconstructive Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard E7 212, Dallas, TX 75390 9132, USA
    Plast Reconstr Surg 110:860-69; quiz 870. 2002
    ..2. The etiology and epidemiology of rhinophyma. 3. Associated diagnosis that can complicate rhinophyma. 4. Common nonsurgical and surgical therapies for rhinophyma. 5. A safe and integrated treatment plan for the patient with rhinophyma...
  17. ncbi Prevalence of rosacea in an Estonian working population using a standard classification
    Kristi Abram
    Clinic of Dermatology, University of Tartu, EE 50417 Tartu, Estonia
    Acta Derm Venereol 90:269-73. 2010
    Data about the prevalence of rosacea are scarce. The aim of this study was to evaluate the prevalence rate of rosacea according to the American National Rosacea Society Expert Committee (NRSEC) classification...
  18. ncbi Glycomics analyses of tear fluid for the diagnostic detection of ocular rosacea
    Hyun Joo An
    Department of Chemistry, University of California, Davis, California 95616, USA
    J Proteome Res 4:1981-7. 2005
    A Glycomics approach to detect disease is illustrated in the analyses of human tear fluid for rosacea. The diagnosis of ocular rosacea is particularly challenging in a subgroup of patients that do not present with typical facial skin ..
  19. ncbi Beneficial use of Cetaphil moisturizing cream as part of a daily skin care regimen for individuals with rosacea
    Sabine Laquieze
    PERITESCO, Paris, France
    J Dermatolog Treat 18:158-62. 2007
    b>Rosacea is a common and chronic disorder characterized by flushing, erythema, papules, pustules, and telangiectasia on the central part of the face...
  20. ncbi Poikiloderma of civatte and rosacea: variants in the same nosological spectrum?
    Alexander C Katoulis
    Dermatology 211:386-7. 2005
  21. ncbi Effective treatment of rosacea using intense pulsed light systems
    Careen A Schroeter
    Department of Lasertherapy, Medical Centre Maastricht, Becanusstraat 17 A05, 6216 BX Maastricht, The Netherlands
    Dermatol Surg 31:1285-9. 2005
    To date, a variety of lasers have been used for treating vascular skin lesions. Intense pulsed light (IPL) is a proven technology for vascular lesion management, such as rosacea.
  22. ncbi Efficacy of topical cyclosporine for the treatment of ocular rosacea
    Barry A Schechter
    Florida Eye Microsurgical Institute, 1717 W Woolbright Road, Boynton Beach, Florida, FL 33426, USA
    Adv Ther 26:651-9. 2009
    This study was designed to compare the efficacy of cyclosporine ophthalmic emulsion 0.05% with an artificial tear solution for the treatment of rosacea-associated eyelid and corneal pathology.
  23. ncbi [Epidemiology of rosacea: updated data]
    O Chosidow
    Service de Dermatologie, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Ann Dermatol Venereol 138:S124-8. 2011
    The epidemiological data on rosacea remain fragmentary and the methodological quality debatable. Rosacea affects mainly adults around the age of 30 years and classically predominates in females...
  24. ncbi Retrospective analysis of the association between Demodex infestation and rosacea
    Ya E Zhao
    Department of Immunology and Pathogen Biology, Medical School of Xi an Jiaotong University, No 76 Yanta W Road, Xi an, China
    Arch Dermatol 146:896-902. 2010
    To explore the association between Demodex infestation and rosacea and the pathogenesis of demodicosis rosacea by means of a meta-analysis.
  25. pmc Rosacea and atopic dermatitis. Two common oculocutaneous disorders
    Benjamin Barankin
    University of Alberta, Edmonton
    Can Fam Physician 48:721-4. 2002
    ..To increase awareness of the oculocutaneous manifestations of two common skin diseases...
  26. pmc Oral azithromycin for treatment of intractable rosacea
    Jae Hong Kim
    Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea
    J Korean Med Sci 26:694-6. 2011
    b>Rosacea is a common chronic cutaneous disorder that primarily occurs on the convex surfaces of the central face and is often characterized by exacerbations and remissions...
  27. ncbi Pimecrolimus 1% cream for the treatment of rosacea
    Moon Bum Kim
    Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea
    J Dermatol 38:1135-9. 2011
    b>Rosacea is a common inflammatory skin disorder; the pathogenesis is unclear. Various treatment options for rosacea are available, but most have limited effectiveness...
  28. ncbi Gnatophyma: a rare rosacea phyma variant
    Erum N Ilyas
    J Am Acad Dermatol 55:165-6. 2006
  29. ncbi Pulsed dye laser treatment of rosacea improves erythema, symptomatology, and quality of life
    Stephen R Tan
    Division of Dermatologic Surgery, Indiana University School of Medicine, University of Minnesota, USA
    J Am Acad Dermatol 51:592-9. 2004
    Persistent erythema and dysesthetic symptoms are typical manifestations of rosacea.
  30. ncbi Cutaneous Rosai-Dorfman disease presenting as a granulomatous rosacea-like rashs
    Xiu yan Shi
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Chin Med J (Engl) 124:793-4. 2011
    A case of cutaneous Rosai-Dorfman disease (CRDD) presenting as a granulomatous rosacea-like rashs was reported. A 45-year-old Chinese woman presented with a 1-month history of a widespread nonpruiginous papulonodular eruption...
  31. ncbi Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group
    B E Elewski
    Department of Dermatology, University of Alabama, Birmingham, AL, USA
    J Eur Acad Dermatol Venereol 25:188-200. 2011
    ..of specific histological or serological markers, the gaps in understanding the aetiology and pathophysiology of rosacea, and the broad diversity in its clinical manifestations has made it difficult to reach international consensus on ..
  32. ncbi Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation
    Enzo Berardesca
    San Gallicano Dermatological Institute, Rome, Italy
    J Cosmet Dermatol 7:8-14. 2008
    This study aims to evaluate a topical treatment based on silymarin/methylsulfonilmethane (S-MSM) to improve erythematous-telangiectactic rosacea.
  33. ncbi Association of rosacea with demodicosis
    Hamideh Moravvej
    Skin Research Center, Department of Dermatology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Arch Iran Med 10:199-203. 2007
    There are controversial reports about the role of Demodex mites in pathogenesis of acne rosacea. The aim of this study was to examine the relationship between the presence and number of Demodex mites and the pathogenesis of rosacea.
  34. ncbi Rosacea: a common, yet commonly overlooked, condition
    B Wayne Blount
    Department of Family Medicine, University of Tennessee Health Science Center, Memphis 38104, USA
    Am Fam Physician 66:435-40. 2002
    b>Rosacea is a common, but often overlooked, skin condition of uncertain etiology that can lead to significant facial disfigurement, ocular complications, and severe emotional distress...
  35. pmc Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea
    Mathias Sulk
    Department of Dermatology, University Hospital Munster, Munster, Germany
    J Invest Dermatol 132:1253-62. 2012
    b>Rosacea is a frequent chronic inflammatory skin disease of unknown etiology. Because early rosacea reveals all characteristics of neurogenic inflammation, a central role of sensory nerves in its pathophysiology has been discussed...
  36. pmc Expression of vascular endothelial growth factor and its receptors in rosacea
    Justine R Smith
    Casey Eye Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Biomedical Research Building, Mail Code L467AD, Portland, OR 97239, USA
    Br J Ophthalmol 91:226-9. 2007
    b>Rosacea is a common chronic disease of unclear pathogenesis, characterised by inflammation and vascular abnormalities of the facial skin and ocular surface...
  37. ncbi Rosacea treatment using the new-generation, high-energy, 595 nm, long pulse-duration pulsed-dye laser
    Eric F Bernstein
    Laser Surgery and Cosmetic Dermatology Centers, Bryn Mawr, Pennsylvania, USA
    Lasers Surg Med 40:233-9. 2008
    b>Rosacea results from sun-induced hyper-vascularity of exposed facial skin, often accompanied by acneiform papules and pustules...
  38. ncbi Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea
    Daniela A Guzman-Sanchez
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Acad Dermatol 57:800-5. 2007
    Although patients with rosacea often complain of increased skin sensitivity, there has been no quantitative sensory testing of this phenomenon...
  39. ncbi Cutaneous and ocular signs of childhood rosacea
    Melanie Chamaillard
    Unité de dermatologie pédiatrique, Place Amelie Raba Leon, 33 076 Bordeaux Cedex, France
    Arch Dermatol 144:167-71. 2008
    Objectives To describe the clinical features of cutaneous and ocular manifestations of childhood rosacea, to propose diagnostic criteria, and to emphasize the possible severity of ocular complications in this age group.
  40. ncbi Granulomatous rosacea-like demodicidosis
    Julia Yu Yun Lee
    Department of Dermatology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Dermatol Online J 13:9. 2007
    Demodicidosis may present as pityriasis folliculitis, papulopustular lesions, rosacea-like eruptions, and granulomatous rosacea-like eruptions...
  41. ncbi Gnatophyma and otophyma
    Navid Ezra
    Division of Dermatology, Department of Medicine, David Geffen Schoool of Medicine at UCLA, Los Angeles, CA, USA
    J Cutan Med Surg 13:266-72. 2009
    Phymas are slowly progressive, disfiguring disorders of the face and ears that represent the end stage of rosacea. The most common phyma is rhinophyma, yet similar swellings may occur on the chin (gnatophyma), forehead (metophyma), one ..
  42. pmc Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus proteins in patients with Facial rosacea
    Jianjing Li
    Ocular Surface Center, Miami, Florida 33173, USA
    Ophthalmology 117:870-877.e1. 2010
    ..To investigate correlation between ocular Demodex infestation and serum...
  43. ncbi Rosacea: 244 Tunisian cases
    Aida Khaled
    Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia
    Tunis Med 88:597-601. 2010
    b>Rosacea is a common, chronic facial dermatosis of uncertain etiology, several well-defined types and variable progression. There is a paucity of epidemiologic studies from North African countries especially in Tunisia.
  44. ncbi Demodex folliculorum in development of dermatitis rosaceiformis steroidica and rosacea-related diseases
    Aleksandra Basta-Juzbasic
    Department of Dermatology and Venerology, Zagreb University Hospital Center, Zagreb, Croatia
    Clin Dermatol 20:135-40. 2002
  45. ncbi Topical corticosteroid-induced rosacea-like dermatitis: a clinical study of 110 cases
    Sanjay K Rathi
    Dermatologist, Siliguri, West Bengal, India
    Indian J Dermatol Venereol Leprol 77:42-6. 2011
    Prolonged and continuous use of topical steroids leads to rosacea-like dermatitis with variable clinical presentations.
  46. ncbi Demodicosis and rosacea: epidemiology and significance in daily dermatologic practice
    Fabienne Forton
    J Am Acad Dermatol 52:74-87. 2005
    ..Demodicoses are thought to be rare, occurring mainly for patients with immunosuppression...
  47. ncbi Incidental control of rosacea by somatostatin
    Claudine Pierard-Franchimont
    Department of Dermatopathology, University Medical Center of Liege, Belgium
    Dermatology 206:249-51. 2003
    The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies.
  48. pmc Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea
    Jianxing Zhang
    Center for Therapeutic Biomaterials, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 6:e16658. 2011
    b>Rosacea is a common disfiguring skin disease of primarily Caucasians characterized by central erythema of the face, with telangiectatic blood vessels, papules and pustules, and can produce skin thickening, especially on the nose of men, ..
  49. ncbi Anti-inflammatory dose doxycycline (40 mg controlled-release) confers maximum anti-inflammatory efficacy in rosacea
    Klaus Theobald
    CollaGenex Pharmaceuticals Inc, 41 University Drive, Newtown, PA 18940, USA
    Skinmed 6:221-6. 2007
    ..recently demonstrated the efficacy of a 40-mg controlled-release formulation of doxycycline in the treatment of rosacea, a dose well below the conventional level of 100 to 200 mg/d...
  50. ncbi A pilot quality-of-life instrument for acne rosacea
    Kimberly Nicholson
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Am Acad Dermatol 57:213-21. 2007
    No rosacea-specific quality-of-life (QOL) instrument exists.
  51. ncbi Gnatophyma: a rare variant of phyma
    M R Vidigal
    Dermatology Service, Hospital Complex Padre Bento de Guarulhos, Sao Paulo, Brazil
    Clin Exp Dermatol 33:743-4. 2008
    We report a case of a 44-year-old woman with an 8-year history of gnatophyma. Rosacea is a facial dermatosis that may present as flushing, erythema, telangiectases, papules, pustules and phyma...
  52. ncbi Antibiotic use in acne vulgaris and rosacea: clinical considerations and resistance issues of significance to dermatologists
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
    Cutis 82:5-12. 2008
    ..Antibiotics are commonly prescribed in dermatology practice for a variety of disorders, including acne vulgaris and rosacea. Importantly, they often are used long-term for these inflammatory dermatoses...
  53. ncbi Otophyma: a case report and review of the literature of lymphedema (elephantiasis) of the ear
    J Andrew Carlson
    Division of Dermatology, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    Am J Dermatopathol 30:67-72. 2008
    Phymas (swellings, masses, or bulbs) are considered the end-stage of rosacea and mostly affect the nose (rhinophyma), and rarely involve the chin (gnatophyma), the cheek (metophyma), eyelids (blepharophyma), or ears (otophyma)...
  54. ncbi BsmI polymorphism of the vitamin D receptor gene in patients with the fulminant course of rosacea conglobata (rosacea fulminans)
    Thomas Jansen
    J Dermatol 31:244-6. 2004
  55. ncbi A study of the pathogenesis of rosacea: how angiogenesis and mast cells may participate in a complex multifactorial process
    Kyriaki Aroni
    Department of Dermatopathology, Medical School, University of Athens, Athens, Greece
    Arch Dermatol Res 300:125-31. 2008
    In the present study we evaluated, in involved and clinically uninvolved skin of Rosacea, microvessels density (MVD) and total vascular area (TVA) in addition to multiple morphologic characteristics of microvessels and also mast cells (..
  56. ncbi Intestinal alkaline phosphatase: the molecular link between rosacea and gastrointestinal disease?
    Joanne Whitehead
    UMR 168 CNRS Institut Curie, 11 rue Pierre et Marie Curie, 75005 Paris, France
    Med Hypotheses 73:1019-22. 2009
    b>Rosacea is a common inflammatory condition of the facial skin of unknown etiology, which frequently occurs in combination with gastrointestinal disorders...
  57. ncbi Laser treatment of erythema and telangiectasia associated with rosacea
    S M Clark
    Department of Dermatology, The University Hospital of Wales, Heath Park, Cardiff, UK
    Lasers Med Sci 17:26-33. 2002
    The response of rosacea-associated erythema and telangiectasia to treatment with the pulsed tunable dye laser (PDL) was evaluated in 12 patients...
  58. ncbi Systemic therapy for rosacea
    H E Baldwin
    Department of Dermatology, State University of New York, Brooklyn, NY, USA
    Skin Therapy Lett 12:1-5, 9. 2007
    b>Rosacea is a common condition that affects people of all races. In addition to the visible aspects of this disease, it can have a psychosocial impact that must be evaluated when considering the treatment options...
  59. ncbi Pimecrolimus 1% cream for the treatment of steroid-induced rosacea: an 8-week split-face clinical trial
    D H Lee
    Department of Dermatology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Br J Dermatol 158:1069-76. 2008
    Steroid-induced rosacea is a relatively common dermatosis that is caused by the prolonged application of topical steroid to the face.
  60. ncbi The potential role of microorganisms in the development of rosacea
    Elizabeth Lazaridou
    First Department of Dermatology Venereology, Aristotle University Medical School, Thessaloniki, Greece
    J Dtsch Dermatol Ges 9:21-5. 2011
    b>Rosacea is a chronic cutaneous disorder characterized by centrofacial persisting erythema, telangiectases, papules, pustules, edema, phymas and ocular involvement...
  61. ncbi The prevalence of ocular signs in acne rosacea: comparing patients from ophthalmology and dermatology clinics
    Vinicius Coral Ghanem
    Department of Ophthalmology, University of California, Davis, Sacramento 95817, USA
    Cornea 22:230-3. 2003
    To describe and compare the ocular signs in patients diagnosed with acne rosacea by the ophthalmologist with the ocular signs in the patients diagnosed with rosacea by the dermatologist.
  62. ncbi Density of Demodex folliculorum in rosacea: a case-control study using standardized skin-surface biopsy
    F Forton
    Clinic of Dermatology, Saint Pierre University Hospital, Universite Libre de Bruxelles, Belgium
    Br J Dermatol 128:650-9. 1993
    A standardized skin-surface biopsy (1 cm2) of the check was performed in 49 patients with rosacea [13 with erythemato-telangiectatic rosacea (ETR), three with squamous rosacea (SR), 33 with papulopustular rosacea (PPR)], and 45 controls...
  63. ncbi Ocular signs, symptoms and tear function tests of papulopustular rosacea patients receiving azithromycin
    O Bakar
    Department of Dermatology, Acibadem Kozyatagi Hospital, Istanbul, Turkey
    J Eur Acad Dermatol Venereol 23:544-9. 2009
    Tetracycline derivatives provide moderate benefit in the treatment of ocular rosacea. Recently, azithromycin has been found to be an effective alternative in the treatment of cutaneous papulopustular rosacea.
  64. ncbi Childhood rosacea
    B Drolet
    Department of Pediatrics and Dermatology, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois
    Pediatr Dermatol 9:22-6. 1992
    b>Rosacea usually occurs in adults and rarely has been noted in children. We recently observed three children with rosacea, all of whom responded dramatically to systemic and topical antibiotics...
  65. ncbi A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial
    Boni E Elewski
    Department of Dermatology, University of Alabama at Birmingham, 35233, USA
    Arch Dermatol 139:1444-50. 2003
    ..75% metronidazole gel (MetroGel; Galderma Laboratories LP, Fort Worth, Tex) as topical therapy for moderate, papulopustular facial rosacea.
  66. ncbi Doxycycline 40 mg capsules (30 mg immediate-release/10 mg delayed-release beads): anti-inflammatory dose in rosacea
    Kate McKeage
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Am J Clin Dermatol 11:217-22. 2010
    ..delayed-release beads) provide a sub-antimicrobial dose that reduces the inflammatory response in patients with rosacea without producing drug concentrations required to treat bacterial diseases...
  67. ncbi Kaposi's varicelliform eruption in association with rosacea
    Isil Kucukyilmaz
    Department of Dermatology, Akdeniz University School of Medicine, Antalya, Turkey
    J Am Acad Dermatol 51:S169-72. 2004
    ..We report here a new case of Kaposi's varicelliform eruption in a 38-year-old woman with rosacea. To our knowledge, this is the first case of Kaposi's varicelliform eruption associated with rosacea to be ..
  68. ncbi Antimicrobials in the treatment of acne and rosacea
    Joseph A Witkowski
    Skinmed 2:202. 2003
  69. ncbi Rosacea: skin innate immunity gone awry?
    Charles L Bevins
    Nat Med 13:904-6. 2007
  70. ncbi Azithromycin in the treatment of papulopustular rosacea
    Tugrul Dereli
    Department of Dermatology, Medical Faculty of Ege University, Izmir, Turkey
    J Dermatol 32:926-8. 2005
  71. pmc TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes
    Kenshi Yamasaki
    Division of Dermatology, Department of Medicine, University of California, San Diego, VA San Diego Health Care System, San Diego, California, USA
    J Invest Dermatol 131:688-97. 2011
    ..b>Rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli...
  72. ncbi Objective and quantitative improvement of rosacea-associated erythema after intense pulsed light treatment
    Kenneth A Mark
    Department of Dermatology, New York University School of Medicine, New York, USA
    Dermatol Surg 29:600-4. 2003
    ..In addition, very few studies specifically address rosacea-associated erythema.
  73. ncbi Oral tetracyclines for ocular rosacea: an evidence-based review of the literature
    Donald U Stone
    Molecular Pathogenesis of Eyer Infection Research Center, Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton I Young Boulevard, Oklahoma City, OK 73104, USA
    Cornea 23:106-9. 2004
    To review the basis for the use of oral tetracyclines in ocular rosacea.
  74. ncbi Therapeutic potential of azithromycin in rosacea
    Ozgür Bakar
    Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey
    Int J Dermatol 43:151-4. 2004
    Systemic antibiotics currently used in the treatment of rosacea are sometimes associated with uncomfortable side-effects. Therefore, a need for an effective agent with few side-effects and good patient compliance exists...
  75. ncbi Systematic review of rosacea treatments
    Esther J Van Zuuren
    Department of Dermatology B1 Q, Leiden University Medical Center, The Netherlands
    J Am Acad Dermatol 56:107-15. 2007
    b>Rosacea is a common chronic skin and ocular condition. It is unclear which treatments are most effective. We have conducted a Cochrane review of rosacea therapies. This article is a distillation of that work.
  76. ncbi Reactive oxygen species and rosacea
    David Jones
    Department of Dermatology, Harvard Medical School, Cambridge, Massachusetts, USA
    Cutis 74:17-20, 32-4. 2004
    Although the fundamental pathogenesis of rosacea remains unknown, inflammation is a central process in this disorder...
  77. ncbi Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea
    Jonathan Wilkin
    Division of Dermatologic and Dental Drug Products, Food and Drug Administration, Rockville, MD, USA
    J Am Acad Dermatol 46:584-7. 2002
  78. ncbi Staphylococcus epidermidis: a possible role in the pustules of rosacea
    Margot Whitfeld
    Department of Dermatology, St Vincent s Hospital, Sydney, Australia
    J Am Acad Dermatol 64:49-52. 2011
    b>Rosacea is a common skin and ocular disease. Cutaneous rosacea is characterized by facial flushing, telangiectasia, papules, and pustules. It is generally regarded as inflammatory in nature...
  79. ncbi Lymphangiogenesis and angiogenesis in non-phymatous rosacea
    Amal H A Gomaa
    Dermatopathology Section, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    J Cutan Pathol 34:748-53. 2007
    Our study evaluated the expression of vascular endothelial growth factor (VEGF), CD31 and D2-40 in involved and uninvolved skin of 18 patients with rosacea.
  80. ncbi Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report
    D Goldman
    Department of Dermatology, NorthBay Healthcare Medical Group, Fairfield, CA 94533, USA
    J Am Acad Dermatol 44:995-8. 2001
    Excessive topical corticosteroid application to facial areas commonly leads to steroid-induced rosacea. This may be a recalcitrant problem that requires months of antibiotic and anti-inflammatory therapy before it resolves.
  81. ncbi The impact of rosacea on quality of life: effects of demographic and clinical characteristics and various treatment modalities
    B Aksoy
    Dermatology Clinic, TDV 29 Mayis Private Ankara Hospital, Ankara, Turkey
    Br J Dermatol 163:719-25. 2010
    b>Rosacea has a major psychosocial impact on a patient's life.
  82. ncbi Oral use of azithromycin for the treatment of acne rosacea
    Adolfo Fernandez-Obregon
    Arch Dermatol 140:489-90. 2004
  83. ncbi The effect of azithromycin on reactive oxygen species in rosacea
    O Bakar
    Department of Dermatology, Acibadem Kozyatagi Hospital, Istanbul, Turkey
    Clin Exp Dermatol 32:197-200. 2007
    Recent evidence suggests that inflammation in rosacea is associated with generation of reactive oxygen species (ROS) that are released by inflammatory cells...
  84. ncbi Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication
    Andrea Parodi
    Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Genoa, Italy
    Clin Gastroenterol Hepatol 6:759-64. 2008
    To better understand the role of small intestinal bacterial overgrowth (SIBO) in rosacea, we aimed to assess the presence of SIBO in patients with rosacea and the clinical effectiveness of its eradication.
  85. ncbi Pediatric ocular acne rosacea: long-term treatment with systemic antibiotics
    Altug Cetinkaya
    Baskent University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey
    Am J Ophthalmol 142:816-21. 2006
    To report our experience with four cases of pediatric ocular acne rosacea, including responses to long-term systemic treatment.
  86. ncbi Steroid-induced rosacea
    J Z Litt
    Case Western Reserve University School of Medicine, Cleveland, Ohio
    Am Fam Physician 48:67-71. 1993
    ..the face often produces an array of skin complications, including an eruption clinically indistinguishable from rosacea ("iatrosacea")...
  87. ncbi Use of the KTP laser in the treatment of rosacea and solar lentigines
    Benjamin A Bassichis
    University of Texas Southwestern Medical Center Division of Facial Plastic and Reconstructive Surgery, Veterans Administration Hospital, Dallas, TX, USA
    Facial Plast Surg 20:77-83. 2004
    Numerous techniques have evolved in facial plastic surgery to treat rosacea and solar lentigines...
  88. ncbi Update on rosacea pathogenesis and correlation with medical therapeutic agents
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
    Cutis 78:97-100. 2006
    The pathogenesis of rosacea is poorly understood, though clinical features of the disease are well-recognized. This article updates current views on mechanisms potentially associated with rosacea...
  89. ncbi Comparative study of some treatment modalities of rosacea
    F F Mostafa
    Department of Dermatology and Venereology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    J Eur Acad Dermatol Venereol 23:22-8. 2009
    b>Rosacea is a disease of complex pathogenesis and variable response to various therapeutic methods. Aim of the work To evaluate and compare the efficacy, safety and side effects of some topical lines of treatment of rosacea.
  90. ncbi Effect of Helicobacter pylori eradication therapy in rosacea patients
    D Boixeda de Miquel
    Department of Gastroenterology, Hospital Ramon y Cajal, Madrid, Spain
    Rev Esp Enferm Dig 98:501-9. 2006
    The causal relation between rosacea and Helicobacter pylori infection is discussed. We evaluated the clinical evolution of rosacea after infection eradication.
  91. ncbi Comparison of anti-inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosacea
    James Q Del Rosso
    Valley Hospital Medical Center, Las Vegas, NV 89121, USA
    J Drugs Dermatol 7:573-6. 2008
  92. ncbi The ocular manifestations of atopic dermatitis and rosacea
    Andrew S Eiseman
    Eye Clinic, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Curr Allergy Asthma Rep 6:292-8. 2006
    Atopic dermatitis and rosacea are chronic diseases that have both dermatologic and ocular manifestations. The occurrence of ocular disease is often proportionately higher than that of dermatologic disease...
  93. ncbi [Repair of an extensive corneoscleral perforation in a case of ocular rosacea with a keratoplasty]
    B Gracner
    Lehrkrankenhaus Maribor, Augenabteilung, Maribor, Slowenien
    Klin Monbl Augenheilkd 223:841-3. 2006
    A 58-year-old female patient with rosacea and a 7year history of eye trouble presented with a spontaneous corneoscleral perforation of the left eye.
  94. ncbi Comparative efficacy of nonpurpuragenic pulsed dye laser and intense pulsed light for erythematotelangiectatic rosacea
    Isaac M Neuhaus
    Dermatologic Surgery and Laser Center, Department of Dermatology, University of California, San Francisco, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA
    Dermatol Surg 35:920-8. 2009
    Erythematotelangiectatic (ET) rosacea is commonly treated with a variety of laser and light-based systems. Although many have been used successfully, there are a limited number of comparative efficacy studies.
  95. ncbi Facial Sweet's syndrome mimicking rosacea fulminans
    Namrata S Anavekar
    Department of Dermatology, St Vincent s Hospital, Melbourne, Victoria, Australia
    Australas J Dermatol 48:50-3. 2007
    ..The initial clinicopathological diagnosis was rosacea fulminans, which was treated with 25 mg oral prednisolone and cephalexin...
  96. ncbi Oxidative stress and ferritin expression in the skin of patients with rosacea
    Vesna Sredoja Tisma
    Polyclinic Department of Dermatology and Venereology, Dubrava University Hospital, Zagreb, Croatia
    J Am Acad Dermatol 60:270-6. 2009
    b>Rosacea is a common chronic light-sensitive inflammatory skin disease of unknown origin...
  97. ncbi Amniotic membrane transplantation in ocular rosacea
    Arun K Jain
    Cornea and External Diseases Section, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
    Ann Ophthalmol (Skokie) 39:71-3. 2007
    A 40-year-old patient with the diagnosis of acne rosacea presented with perforated peripheral corneal ulcer. Three applications of cyanoacrylate glue along with bandage contact lens failed to seal the perforation...
  98. ncbi Updates on the pathophysiology and management of acne rosacea
    Mohamed L Elsaie
    Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL 33136, USA
    Postgrad Med 121:178-86. 2009
    There are many options for the treatment of acne rosacea, including topical and systemic therapies, laser and light-based therapies, and surgical procedures...
  99. ncbi Successful treatment of the erythema and flushing of rosacea using a topically applied selective alpha1-adrenergic receptor agonist, oxymetazoline
    Stuart D Shanler
    School of Medicine, University of New Mexico, Albuquerque, USA
    Arch Dermatol 143:1369-71. 2007
  100. ncbi Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, 3350 La Jolla Village Drive, San Diego, California 92161, USA
    Nat Med 13:975-80. 2007
    Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by erythema, papulopustules and telangiectasia...
  101. ncbi Combined effect of anti-inflammatory dose doxycycline (40-mg doxycycline, usp monohydrate controlled-release capsules) and metronidazole topical gel 1% in the treatment of rosacea
    Joseph F Fowler
    Department of Medicine, Division of Dermatology, University of Louisville, Louisville, KY, USA
    J Drugs Dermatol 6:641-5. 2007
    Research into the pathophysiology of rosacea suggests a central role for inflammatory mediators such as nitric oxide (NO), reactive oxygen species (ROS), and matrix metalloproteinases (MMPs)...

Research Grants21

  1. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..novel therapeutic strategies to combat skin diseases that have a neuronal component, like atopic dermatitis and other eczemas, or rosacea, and to reduce the adverse symptoms associated with these conditions, including pruritus and pain.
  2. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..We have developed a murine model of bladder inflammation extrapolated from the pathophysiology of skin lesions in rosacea, which express high levels of the antimicrobial cathelicidin peptide LL-37...
  3. Skin Defense by Antimicrobial Peptides
    Richard L Gallo; Fiscal Year: 2012
    ..We have discovered much about the etiology of rosacea and why patients with atopic dermatitis are susceptible to infection...
  4. Proteolysis and Skin Antimicrobials
    Richard L Gallo; Fiscal Year: 2013
    ..Control of this processing is relevant to skin diseases ie. rosacea and psoriasis...
  5. A Novel Class of Therapeutic Agents for the Treatment of Skin Diseases Associated
    Joel S Gordon; Fiscal Year: 2010
    ..g. atopic dermatitis, seborrheic dermatitis) and rosacea. PUBLIC HEALTH RELEVANCE: Treatment for chronic inflammatory skin diseases characterized by a prominent degree of ..
  6. Safety and Efficacy of Single-use Cliradex Pads for Ocular Mites
    Scheffer C G Tseng; Fiscal Year: 2012
    ..Uncontrolled overgrowth of mites has been implicated in causing papulopustular lesions in the skin, rosacea in the face, and blepharitis in the eye...
  7. Sulfated Polysaccharide Derivatives for the Treatment of Rosacea
    NARAYANAM RAO; Fiscal Year: 2009
    b>Rosacea is a common disfiguring skin disease affecting 3% of the population over 30 years of age, or 14 million Americans...
  8. Cathelicidin in Skin Immunity
    Victor Nizet; Fiscal Year: 2013
    ..showing abnormal production contributes to the pathophysiology of skin diseases such as atopic dermatitis, rosacea and psoriasis...
  9. A Topical Non Steroidal Anti-inflammatory for Rosacea
    Eduardo Perez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rosacea is a chronic dermatological condition characterized by flushing, erythema, papules, pustules, inflammatory nodules and telangiectasia...
  10. Tea Tree Oil for Treating Ocular Demodex Infestation
    Scheffer Tseng; Fiscal Year: 2009
    ..Uncontrolled overgrowth of these mites has been implicated in causing rosacea in the face, blepharitis in the eyelid, and other inflammation-associated conjunctival and corneal abnormalities...
  11. TEAR FUNCTION IN BLEPHARITIS AND DRY EYE
    William Mathers; Fiscal Year: 2000
    ..2d) Evaluate patients with Rosacea and seborrheic dermatitis to determine the effects of these dermatologic diseases on the tear film...
  12. Goblet Cell Stimulation Via Electric Charge Flux & Field
    BRADLEY VEATCH; Fiscal Year: 2005
    ..patients at increased risk for the disease, including diabetes, lupus, arthritis, leukemia, fibromyalgia, acne rosacea, and Sjogren's syndrome...
  13. 2007 Antimicrobial Peptides Gordon Conference
    Richard Gallo; Fiscal Year: 2007
    ..The organizational philosophy is to encourage diverse[unreadable] participation, and maintain an eye towards gender issues, junior scientists, minorities, and individuals with[unreadable] physical limitations. ..
  14. PROTEOGLYCANS WOUND REPAIR AND INFLAMMATION
    Richard Gallo; Fiscal Year: 2005
    ..The GAG ligand(s) responsible for activation will be sought and gene expression profiles investigated. Successful completion of these aims will reveal fundamental events in wound repair and may suggest new approaches to wound therapy. ..
  15. Mechanisms of Tumor Promotion Effects of B[a]PDE
    Chuanshu Huang; Fiscal Year: 2008
    ..Such agents could interfere with the signaling pathways leading to AP-1 activation. ..
  16. Values of Families in Guiding End-of-Life Care
    Charles Gessert; Fiscal Year: 2002
    ..This research will lay the groundwork for two future studies: a survey of values in end-of-life decision-making, and an in depth examination of the role of selected values in decision-making. ..
  17. Chemoprevention of Esophageal Squamous Cell Carcinoma
    Gary Stoner; Fiscal Year: 2004
    ..abstract_text> ..
  18. Role of Retinal Microvasculature in Posterior Uveitis
    Justine Smith; Fiscal Year: 2006
    ..The studies should also have implications for unrelated diseases affecting the retinal circulation, as well as tissue-specific inflammations and infections at other body sites. [unreadable] [unreadable]..
  19. Effects of Arsenic on PI-3K Signaling Pathway
    Chuanshu Huang; Fiscal Year: 2007
    ..Such agents could interfere with signaling pathways leading to cyclin D1 induction, cell proliferation and cell transformation. ..
  20. Nitric Oxide Synthase Polymorphisms and Risk for Skin Cancer
    Abrar Qureshi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..