Genomes and Genes
Summary: A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.
Publications268 found, 100 shown here
- Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidismMichelle Welsh
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
J Clin Invest 118:1479-90. 2008..Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear...
- Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connectionJorma Toppari
Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku, Finland
Birth Defects Res A Clin Mol Teratol 88:910-9. 2010b>Cryptorchidism and hypospadias are common genital birth defects that affect 2-9% and 0.2-1% of male newborns, respectively...
- Spermatogenesis in cryptorchidismAlexander I Agoulnik
Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
Methods Mol Biol 825:127-47. 2012b>Cryptorchidism or undescended testis is the most frequent congenital abnormality in newborn boys. The process of testicular descent to the scrotum is controlled by hormones produced in Leydig cells, insulin-like3, and androgens...
- Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspectsN E Skakkebaek
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Hum Reprod 16:972-8. 2001..Otherwise, important biological information may be lost...
- Insulin-like 3 signalling in testicular descentIbrahim M Adham
Institute of Human Genetics, University of Gottingen, Gottingen, Germany
Int J Androl 27:257-65. 2004Undescended testis is one of the most common congenital defects in the newborn boys and the common cause of cryptorchidism. If left untreated, this condition is strongly associated with infertility and drastically increased risk of ..
- Cryptorchidism and maternal alcohol consumption during pregnancyIda N Damgaard
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Environ Health Perspect 115:272-7. 2007Prenatal exposure to alcohol can adversely affect the fetus. We investigated the association between maternal alcohol consumption during pregnancy and cryptorchidism (undescended testis) among newborn boys.
- An oligonucleotide microarray study on gene expression profile in mouse testis of experimental cryptorchidismYin Chuan Li
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, P R China
Front Biosci 11:2465-82. 2006..patterns on day 1, day 4, day 7, day 14, day 28 and normal control adult mouse testis after experimental cryptorchidism (EC) using Affymetrix MOE430A microarray...
- Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult miceZaohua Huang
Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA
Biol Reprod 87:143. 2012..Deletion of Insl3 or Rxfp2 genes in mice caused cryptorchidism resulting from a failure of gubernaculum development...
- Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R StudyClaudia A Snijder
The Generation R Study Group, Erasmus University Medical Centre, Dr Molewaterplein 50 60, 3015 GE Rotterdam, The Netherlands
Hum Reprod 27:1191-201. 2012..We examined the influence of maternal exposure to mild analgesics during pregnancy on the occurrence of cryptorchidism and hypospadia in their offspring.
- Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placentaH E Virtanen
Departments of Physiology and Paediatrics, University of Turku, Turku, Finland
Int J Androl 35:283-93. 2012..In addition, one previous case-control study has reported an association between congenital cryptorchidism and colostrum PCB levels...
- Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2Jing Chen
Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
Hum Reprod 27:2585-97. 2012..conductance regulator (CFTR) down-regulation in Sertoli cells in cryptorchid testis disrupt testicular tight junctions (TJs) through the nuclear factor kappa B (NF-κB)/cyclooxygenase-2 (COX-2)/prostaglandin E(2) (PGE(2)) pathway?..
- INSL3/LGR8 role in testicular descent and cryptorchidismN V Bogatcheva
Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Reprod Biomed Online 10:49-54. 2005b>Cryptorchidism, generally referred to a failure of testicular descent into the scrotum, is the most frequent (up to 3-4% at birth) congenital anomaly in newborn boys...
- Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidismMorten Søndergaard Jensen
Perinatal Epidemiology Research Unit, Departments of Obstetrics and Pediatrics, Aarhus University Hospital, Skejby, Denmark
Epidemiology 21:779-85. 2010..We examined whether prenatal exposure to acetaminophen, ibuprofen, and acetylsalicylic acid was associated with increased occurrence of cryptorchidism.
- CryptorchidismJohn M Hutson
Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
Semin Pediatr Surg 19:215-24. 2010b>Cryptorchidism is a very common anomaly of the male genitalia, affecting 2%-4% of male infants and is more common in premature infants. There are two separate stages of testicular descent...
- The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohortC L Acerini
Department of Paediatrics, University of Cambridge, Cambridge, UK
Arch Dis Child 94:868-72. 2009Recent studies in other European countries suggest that the prevalence of congenital cryptorchidism continues to increase. This study aimed to explore the prevalence and natural history of congenital cryptorchidism in a UK centre.
- Epidemiology and pathogenesis of cryptorchidismH E Virtanen
Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
Hum Reprod Update 14:49-58. 2008Prospective clinical studies have shown that the prevalence of cryptorchidism among boys with birth weight > or =2500 g has increased in UK from 2.7 to 4.1% between the 1950s and the 1980s and in Denmark from 1.8 to 8...
- Maternal smoking, alcohol consumption, and caffeine consumption during pregnancy in relation to a son's risk of persistent cryptorchidism: a prospective study in the Child Health and Development Studies cohort, 1959-1967Morgana L Mongraw-Chaffin
Child Health and Development Studies, Center for Research on Women s and Children s Health, Public Health Institute, Berkeley 94709, CA
Am J Epidemiol 167:257-61. 2008..Other maternal and perinatal risk factors were not significantly associated with persistent cryptorchidism and did not confound the association with caffeine.
- Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controlsA M Andersson
Department of Growth and Reproduction, Copenhagen University Hospital, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen OE, Denmark
J Clin Endocrinol Metab 89:3161-7. 2004..On the other hand, the parallel impairment of spermatogenesis and Leydig cells may reflect a congenital dysfunction of both compartments caused by a testicular dysgenesis during fetal/infant development...
- Cryptorchidism in mice mutant for Insl3S Nef
Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas 75235 9133, USA
Nat Genet 22:295-9. 1999Impaired testicular descent (cryptorchidism) is one of the most frequent congenital abnormalities in humans, involving 2% of male births. Cryptorchidism can result in infertility and increases risk for development of germ-cell tumours...
- The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: a population-based case-control study in rural SicilyP Carbone
Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
Int J Androl 30:3-13. 2007..and domestic exposures to potential endocrine disrupting chemicals (EDC) assessed by questionnaire and cryptorchidism and hypospadias in their offspring in the agricultural area of Ragusa...
- Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidismChristopher R Cederroth
Department of Genetic Medicine and Development University of Geneva Medical School 1, rue Michel Servet, CH 1211, Geneva 4, Switzerland
Endocrinology 148:5507-19. 2007Failure of the testes to descend into the scrotum (cryptorchidism) is one of the most common birth defects in humans...
- Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterizationA Ferlin
Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
Mol Hum Reprod 12:401-6. 2006..or its G protein-coupled receptor, leucine-rich repeat-containing G-protein-coupled receptor (Lgr8), causes cryptorchidism in mice...
- 13 Years' experience with the combined hormonal therapy of cryptorchidismM F Giannopoulos
Clinic of Pediatric Surgery, University Hospital Heraklion, University of Crete, Heraklion, Crete, Greece
Horm Res 55:33-7. 2001..hormone releasing hormone (LH-RH) and human chorionic gonadotropin (HCG) of a large series of patients with cryptorchidism. MATERIALS AND METHODS: Between 1987 and 1999 and after strict differentiation between cryptorchid, retractile ..
- Importance of early postnatal germ cell maturation for fertility of cryptorchid malesF Hadziselimovic
Kindertagesklinik, Liestal, Switzerland
Horm Res 55:6-10. 2001..This underscores the importance of a testicular biopsy at orchidopexy in order to identify those who could benefit from early LH-RH treatment after orchidopexy...
- The CAG repeat within the androgen receptor gene and its relationship to cryptorchidismM Silva-Ramos
Department of Urology, Santo Antonio General Hospital, Porto, Portugal
Int Braz J Urol 32:330-4; discussion 335. 2006We examined the significance of the CAG repeat polymorphism in the pathogenesis of cryptorchidism.
- Prenatal alcohol exposure and cryptorchidismM S Jensen
Department of Occupational Medicine, University Hospital of Aarhus, Aarhus, Denmark
Acta Paediatr 96:1681-5. 2007A recently published study reported markedly increased risk of cryptorchidism among boys whose mothers had an average gestational alcohol intake of five or more drinks per week...
- Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidismKatrine Bay
University Department of Growth and Reproduction, Rigshospitalet, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
J Clin Endocrinol Metab 92:4020-7. 2007The Leydig cell hormone insulin-like factor 3 (INSL3) is important for testicular descent. Currently INSL3 levels in cord blood, in serum throughout childhood, and in relation to congenital cryptorchidism are unknown.
- Differential gene expression in the testes of different murine strains under normal and hyperthermic conditionsYing Li
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
J Androl 30:325-37. 2009b>Cryptorchidism and scrotal heating result in abnormal spermatogenesis, but the mechanism(s) prescribing this temperature sensitivity are unknown...
- A transgenic insertion causing cryptorchidism in miceP A Overbeek
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Genesis 30:26-35. 2001..Failure in this process results in cryptorchidism, a frequent congenital birth defect in humans...
- Attenuation of spermatogonial stem cell activity in cryptorchid testesHideyuki Kamisawa
Department of Nephro urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
J Urol 187:1047-52. 2012To elucidate the mechanism of infertility caused by cryptorchidism we focused on early stage spermatogenesis and spermatogonial stem cell activity in undifferentiated spermatogonia in cryptorchid testes.
- Inadvertent exposure to xenoestrogens in childrenN Olea
Laboratory of Medical Investigations, School of Medicine, University of Granada, Spain
Toxicol Ind Health 15:151-8. 1999..with a hypothetical association between exposure to hormone-disruptive chemicals and the induction of cryptorchidism. Several methodological limitations in the study design make it necessary to evaluate the results with caution...
- Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposuresK Krysiak-Baltyn
Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
Int J Androl 35:294-302. 2012..To study the association between complex chemical exposures of humans and congenital cryptorchidism, the most common malformation of the male genitalia, we measured 121 environmental chemicals with suspected or ..
- Cryopreservation of intact testicular tissue from boys with cryptorchidismK Kvist
Laboratory of Reproductive Biology, Section 5712, Department of Paediatric Surgery, Section 4072, University Hospital of Copenhagen, Rigshospitalet, DK 2100 Copenhagen, Denmark
Hum Reprod 21:484-91. 2006Boys with cryptorchidism often face fertility problems in adult life despite having orchiopexy performed at a very young age...
- Hormonal changes in 3-month-old cryptorchid boysAnne Maarit Suomi
Department of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
J Clin Endocrinol Metab 91:953-8. 2006Hormonal dysregulation has been suggested to be one of many etiological factors of cryptorchidism.
- The incidence of bilateral cryptorchidism is increased and the fertility potential is reduced in sons born to mothers who have smoked during pregnancyJ Thorup
Department of Pediatric Surgery, Rigshospitalet, University of Copenhagen, Denmark
J Urol 176:734-7. 2006Recent studies have demonstrated a high prevalence of cryptorchidism, decreasing semen quality and increasing incidence of testicular cancer...
- The importance of mini-puberty for fertility in cryptorchidismFaruk Hadziselimovic
Department of Pediatrics, Kindertagesklinik, Oristalstrasse, Liestal, Switzerland
J Urol 174:1536-9; discussion 1538-9. 2005..It induces the development and transformation of gonocytes into Ad spermatogonia, which is impaired in many cryptorchid testes. We examine the role of testosterone in the transformation and development of Ad spermatogonia...
- Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testisElena M Kaftanovskaya
Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, Florida 33199, USA
Mol Endocrinol 26:598-607. 2012..The GU-ARKO males had normal testosterone levels but developed cryptorchidism with the testes located in a suprascrotal position...
- Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidismC Krausz
Immunogenetique Humaine, INSERM U276, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Hum Reprod 6:298-302. 2000The aetiology of cryptorchidism is for the most part unknown and appears to be multifactorial...
- The anatomy of the cremaster muscle during inguinoscrotal testicular descent in the ratEfrant J Harnaen
F Douglas Stephens Surgical Research Laboratory, Murdoch Childrens Research Institute, Melbourne, Australia
J Pediatr Surg 42:1982-7. 2007..This study investigated cremaster muscle anatomy and ontogeny in both normal and cryptorchid rat models...
- Retractile testis--is it really a normal variant?Piyush K Agarwal
Division of Pediatric Urology, Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
J Urol 175:1496-9. 2006..Retractile testes are thought to represent a normal variant of descended testes in prepubertal boys. We studied retractile testes to determine their natural history...
- Maternal diet and the risk of hypospadias and cryptorchidism in the offspringFelice Giordano
Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
Paediatr Perinat Epidemiol 22:249-60. 2008..The purpose of this study was to explore the association between hypospadias and cryptorchidism, and the dietary habits of an agricultural population in Italy...
- Cryptorchidism in common eutherian mammalsR P Amann
Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado 80523 1683, USA
Reproduction 133:541-61. 2007b>Cryptorchidism is failure of one or both testes to descend into the scrotum. Primary fault lies in the testis. We provide a unifying cross-species interpretation of testis descent and urge the use of precise terminology...
- Morphometric study of the gubernaculum in male estrogen receptor mutant miceK M Donaldson
F Douglas Stephens Surgical Research Laboratory, Royal Children s Hospital Research Foundation, Melbourne, Australia
J Androl 17:91-5. 1996..This study demonstrates that estrogen has a previously unknown role in masculine sexual development of the gubernaculum and the structures derived from it, such as the cremaster muscle...
- Altered expression of muscle- and cytoskeleton-related genes in a rat strain with inherited cryptorchidismJulia S Barthold
Nemours Biomedical Research and Division of Urology, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
J Androl 29:352-66. 2008..These data suggest that the orl mutation results in a primary gubernacular defect that affects muscle development and cytoskeletal function and might alter androgen-regulated pathways...
- Hormonal cryptorchidism therapy: systematic review with metanalysis of randomized clinical trialsMárcia Riromi Henna
Pediatr Surg Int 20:357-9. 2004The importance of cryptorchidism treatment concerns the possibility of diminishing risk of malignant degeneration and improving fertility...
- Mutations of the GREAT gene cause cryptorchidismIvan P Gorlov
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 11:2309-18. 2002In humans, failure of testicular descent (cryptorchidism) is one of the most frequent congenital malformations, affecting 1-3% of newborn boys...
- Cryptorchidism: an indicator of testicular dysgenesis?Marko Kaleva
Department of Physiology, University of Turku, 20520 Turku, Finland
Cell Tissue Res 322:167-72. 2005b>Cryptorchidism is a common ailment of new-born boys, affecting 1-9% of full term boys at birth. Cryptorchidism has been associated with an increased risk of testicular cancer and reduced fertility...
- Accuracy of ultrasonography and magnetic resonance imaging in the diagnosis of non-palpable testisKazuhiro Kanemoto
Department of Nephro urology and Quantum Radiology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
Int J Urol 12:668-72. 2005..Studies were needed to evaluate the accuracy of ultrasonography (US) and magnetic resonance imaging (MRI) for diagnosing non-palpable testis, and to study the clinical usefulness of US and MRI before surgical exploration...
- Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancerThomas J Walsh
Department of Urology, University of California San Francisco, San Francisco, California 94143 1695, USA
J Urol 178:1440-6; discussion 1446. 2007..We hypothesize that early orchiopexy is protective against subsequent development of testicular germ cell cancer...
- The insulin-3 gene: lack of a genetic basis for human cryptorchidismLinda A Baker
John W Duckett, M D Laboratory in Pediatric Urology, Department of Urology and Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
J Urol 167:2534-7. 2002The etiology of cryptorchidism appears to be multifactorial and related to hormonal and mechanical factors. Recently, the insulin-3 gene (INSL3) was noted to have a role in mouse gubernacular development and testicular descent...
- Cryptorchidism: aspects of fertility and neoplasms. A study including data of 1,335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidismD Cortes
Department of Pediatric Surgery, Rigshospitalet, Denmark
Horm Res 55:21-7. 2001PURPOSE: An attempt to make a rational strategy for treatment of cryptorchidism. MATERIALS AND METHODS: 1,335 cryptorchid boys with biopsy at surgery (1,638 specimens)...
- Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadiasXian Yang Qin
Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
J Hum Genet 57:434-41. 2012..ARNT, ARNT2, NR1I2, RXRA, RXRB, RXRG, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP3A4, CYP17A1 and CYP19A1) and risk of cryptorchidism (CO) and hypospadias (HS) in 334 Japanese (JPN) males (141 controls, 95 CO and 98 HS) and 187 Italian (ITA) ..
- A critical appraisal of the evidence for improved fertility indices in undescended testes after gonadotrophin-releasing hormone therapy and orchidopexyS M Biers
Department of Paediatric Urology, Southampton General Hospital, Division of Women and Children, Care Group Child Health MP43, G Level East Wing, Tremona Road, Southampton, Hampshire SO16 6YD, UK
J Pediatr Urol 6:239-46. 2010..We suggest that the evidence is sufficiently strong to recommend a change in clinical practice...
- Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen dataP A Lee
Graduate School of Public Health, University of Pittsburgh, PA, USA
Horm Res 55:28-32. 2001..Evaluation of the fertility of a cohort of formerly bilaterally cryptorchid men in comparison with a group of formerly unilaterally cryptorchid men, and a group of control men...
- Diagnostic performance of ultrasound in nonpalpable cryptorchidism: a systematic review and meta-analysisGregory E Tasian
Department of Urology, University of California, San Francisco, CA 94143 0738, USA
Pediatrics 127:119-28. 2011..Ultrasound is frequently obtained during the presurgical evaluation of boys with nonpalpable undescended testes, but its clinical utility is uncertain...
- Management of cryptorchidism in children: guidelinesChristophe Gapany
Service of Pediatric Surgery, Centre Hospitalier Universitaire Vaudois, and University of Lausanne, Lausanne, Switzerland
Swiss Med Wkly 138:492-8. 2008To develop clinical guidelines for the management of cryptorchidism in pre-pubertal boys, from early diagnosis through therapy to long-term follow-up and prognosis.
- Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidismF Hadziselimovic
Kindertagesklinik Liestal, Liestal, Switzerland
Klin Padiatr 220:302-7. 2008..However, in boys with cryptorchidism early successful surgery cannot prevent infertility if they lack Ad spermatogonia...
- Testicular descent and cryptorchidism: the state of the art in 2004John M Hutson
F Douglas Stephens Surgical Research Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
J Pediatr Surg 40:297-302. 2005..Recent advances include the recognition of acquired cryptorchidism of critical early postnatal germ cell development and the recommendation for surgery at 6 months of age...
- Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspringKatherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
Environ Health Perspect 117:1472-6. 2009The etiologies of the male urogenital anomalies cryptorchidism and hypospadias are poorly understood. It has been suggested, however, that in utero hormone levels may be related to risk...
- Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidismLise Aksglaede
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Acta Paediatr 100:839-45. 2011..AMH is a testis-specific marker of diagnostic value in infants with ambiguous genitalia or with bilateral cryptorchidism. However, little is known about AMH in boys and adult men with normal or abnormal gonadal function...
- Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchiopexy at age 9 months or 3 yearsClaude Kollin
Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
J Urol 178:1589-93; discussion 1593. 2007..We compared the growth of congenital, unilaterally undescended testes following orchiopexy at age 9 months or 3 years...
- Advances in molecular genetics of cryptorchidismYoshiyuki Kojima
Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
Urology 74:571-8. 2009b>Cryptorchidism is the most common congenital disorder in boys; one major complication of this disorder is male infertility...
- Age at surgery for undescended testis and risk of testicular cancerAndreas Pettersson
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
N Engl J Med 356:1835-41. 2007..We studied the relation between the age at treatment for undescended testis and the risk of testicular cancer...
- Cryptorchidism: classification, prevalence and long-term consequencesHelena E Virtanen
Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
Acta Paediatr 96:611-6. 2007..There are unexplained geographical differences and temporal trends in its prevalence. Cryptorchidism, especially bilateral, is associated with impaired spermatogenesis and endocrine function and increases the ..
- Androgen receptor gene CAG and GGC repeat lengths in cryptorchidismAlberto Ferlin
University of Padova, Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, 35121 Padova, Italy
Eur J Endocrinol 152:419-25. 2005b>Cryptorchidism is the most common congenital birth defect in male children, and accumulating evidence suggests that genetic abnormalities may be associated with it...
- Acquired cryptorchidism is frequent in infancy and childhoodChristine Wohlfahrt-Veje
University Department of Growth and Reproduction, GR 5064 Rigshospitalet, Copenhagen, Denmark
Int J Androl 32:423-8. 2009Accurate prevalence data for acquired cryptorchidism are currently sparse and systematic prospective studies have not yet been reported. Our aim was to determine the prevalence of testicular ascent in childhood...
- Cryptorchidism concordance in monozygotic and dizygotic twin brothers, full brothers, and half-brothersMorten Søndergaard Jensen
Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
Fertil Steril 93:124-9. 2010To study concordance rates of cryptorchidism (undescended testis) in pairs of boys with varying family structure, to evaluate the risk contribution from the intrauterine environment and genetic factors.
- Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruptionMichael H Hsieh
Scott Department of Urology, Texas Children s Hospital, Clinical Care Center, Baylor College of Medicine, Suite 660, 6621 Fannin Street, Houston, TX 77030, USA
Curr Urol Rep 9:137-42. 2008..disruptors, such as environmental compounds with endocrine-altering properties, may cause hypospadias and cryptorchidism in several species, including humans...
- Abnormal germ cell development in cryptorchidismD S Huff
Department of Pathology and Division of Pediatric Urology, Childrens Hospital of Philadelphia, PA 19104, USA
Horm Res 55:11-7. 2001..The purpose of this study is to confirm the previous findings of defective germ cell maturation in a large series of boys with unilateral undescended testes...
- Targeted disruption of the Insl3 gene causes bilateral cryptorchidismS Zimmermann
Institut für Humangenetik der Universität Göttingen, Germany
Mol Endocrinol 13:681-91. 1999..Here we show that male mice homozygous for a targeted deletion of the Insl3 locus exhibit bilateral cryptorchidism with free moving testes and genital ducts...
- Functional analysis of spermatogonial stem cells in Steel and cryptorchid infertile mouse modelsT Shinohara
Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Dev Biol 220:401-11. 2000..Thus, cryptorchid testes provide an important approach for purification and characterization of spermatogonial stem cells...
- Anti-Müllerian hormone levels in serum from human foetuses and children: pattern and clinical interestJ Guibourdenche
Department of Biochemistry, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
Mol Cell Endocrinol 211:55-63. 2003..When testes cannot be palpated, a single determination of serum AMH levels can distinguish between anorchia and cryptorchidism.
- Cryptorchidism and testicular cancer: separating fact from fictionHadley M Wood
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 48202, USA
J Urol 181:452-61. 2009We dissected prevailing assumptions about cryptorchidism and reviewed data that support and reject these assumptions.
- Reproductive dysgenesis in wildlife: a comparative viewThea M Edwards
Department of Zoology, University of Florida, Gainesville, 32611, USA
Int J Androl 29:109-21. 2006..TDS is also described as demasculinization or feminization of the male phenotype. The suite includes cryptorchidism, in situ germ cell carcinoma of the testis and overt testicular cancer, reduced semen quality, and hypospadias...
- Development and descent of the testis in relation to cryptorchidismHelena E Virtanen
Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
Acta Paediatr 96:622-7. 2007..In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial...
- Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum developmentElena M Kaftanovskaya
Department of Human Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
Mol Endocrinol 25:170-83. 2011..Deletion of Insl3 or its receptor, Rxfp2, in mice causes cryptorchidism. We produced Cre/loxP regulated shRNA transgenic mice targeting RXFP2 expression...
- Testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidismJay D Raman
James Buchanan Brady Urology Foundation, Department of Urology, Center for Male Reproductive Medicine and Microsurgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
J Urol 170:1287-90. 2003We evaluated the results of testicular sperm extraction (TESE) with intracytoplasmic sperm injection (ICSI) in men with nonobstructive azoospermia (NOA) associated with cryptorchidism.
- The undescended testis: diagnosis, treatment and long-term consequencesMichael J Mathers
Urologische Gemeinschaftspraxis Remscheid, Kooperationspraxis der Klinik für Urologie und Kinderurologie, Klinikum Wuppertal, Universitat Witten Herdecke
Dtsch Arztebl Int 106:527-32. 2009..Reduced fertility is the main risk of primary cryptorchidism even after timely treatment, as histopathological changes (Leydig cell hypoplasia) already become apparent in ..
- Results of orchiopexy for the undescended testisIrina Taran
Division of Pediatric Urology, Rainbow Babies and Children s Hospital, Department of Urology, Case School of Medicine, Cleveland, OH 44106, USA
World J Urol 24:231-9. 2006..The risk of testicular carcinoma is increased by a factor of 3.7 to 7.5 times. Tumor type is most commonly seminoma if the testis is undescended, whereas tumors that occur following orchiopexy are much more likely to be nonseminomatous...
- Higher than expected prevalence of congenital cryptorchidism in Lithuania: a study of 1204 boys at birth and 1 year follow-upR T Preiksa
Institute of Endocrinology, Kaunas University of Medicine, LT 50009 Kaunas, Lithuania
Hum Reprod 20:1928-32. 2005b>Cryptorchidism at birth is one of the symptoms of testicular dysgenesis syndrome (TDS). The aim of the study was to detect prevalence of cryptorchidism in Lithuanian newborn boys.
- Parental and neonatal risk factors for cryptorchidismNorie Kurahashi
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Med Sci Monit 11:CR274-283. 2005b>Cryptorchidism is one of the most common congenital malformations in males...
- What is new in cryptorchidism and hypospadias--a critical review on the testicular dysgenesis hypothesisJorgen Thorup
Department of Pediatric Surgery, Faculty of Health Science, University of Copenhagen, Rigshospitalet, DK 2100 Copenhagen, Denmark
J Pediatr Surg 45:2074-86. 2010..In more than 95% of the cases, hypospadias is not associated with cryptorchidism, suggesting major differences in pathogenesis...
- INSL3/RXFP2 signaling in testicular descentShu Feng
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
Ann N Y Acad Sci 1160:197-204. 2009Mutations of the insulin-like peptide 3 (INSL3) hormone or its receptor, RXFP2, cause intraabdominal cryptorchidism in male mice. Specific RXFP2 expression in mouse gubernacula was detected at embryonic day 14...
- Management of cryptorchism and risk of testicular cancerLisa J Herrinton
Division of Research, Kaiser Permanente, Oakland, CA 94612, USA
Am J Epidemiol 157:602-5. 2003..In contrast, all four of the early orchiopexies performed on the controls were successful. Boys with failed orchiopexy should be considered for reoperative orchiopexy or orchiectomy to prevent testicular cancer...
- Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidismJaesook Roh
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
Reprod Biomed Online 7:400-6. 2003b>Cryptorchidism is the most frequent congenital anomaly of the urogenital tract in the male. Although in Western countries 1-2% of males at the age of 3 months are diagnosed with this condition, its aetiology is still unknown...
- Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adultL Dunkel
Children s Hospital, University of Helsinki, Finland
J Clin Invest 100:2341-6. 1997b>Cryptorchidism results in impaired fertility. Reduced numbers of testicular germ cells can be shown histologically during the first years of life...
- Fertility after cryptorchidism: epidemiology and other outcome studiesPeter A Lee
Department of Pediatrics, Pennsylvania State College of Medicine, The Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
Urology 66:427-31. 2005
- Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidismD Zuccarello
Department of Molecular Medicine and Pathology, University La Sapienza, Rome, Italy
J Endocrinol Invest 27:760-4. 2004In testicular descent to the scrotum, a multistep process, many anatomical and hormonal factors play a role. Cryptorchidism occurs in about 1-2% of males and may cause secondary degeneration of the testes...
- Hormonal treatment for unilateral inguinal testis: comparison of four different treatmentsS Bertelloni
Endocrine Unit, Division of Paediatrics, Santa Chiara Hospital, University of Pisa, Italy
Horm Res 55:236-9. 2001Hormonal treatment of cryptorchidism has been used since the 30s, but controversies persist on its efficacy. It is also unclear whether there are differences with the use of different hormonal trials.
- Age at orchiopexy and testis palpability predict germ and Leydig cell loss: clinical predictors of adverse histological features of cryptorchidismGregory E Tasian
Department of Urology, University of California San Francisco, San Francisco, California 94143 0738, USA
J Urol 182:704-9. 2009We determined the relationship between clinical variables and testicular histopathological changes associated with decreased fertility potential in children with cryptorchidism.
- A missense mutation in LRR8 of RXFP2 is associated with cryptorchidismRebecca M Harris
Department of Medicine, Feinberg School of Medicine, Northwestern University, Arthur J Rubloff Building, 420 E Superior St, Suite 12 109, Chicago, IL 60611, USA
Mamm Genome 21:442-9. 2010Using genome-wide mutagenesis with N-ethyl-N-nitrosourea (ENU), a mouse mutant with cryptorchidism was identified...
- ESR1 promoter polymorphism is not associated with nonsyndromic cryptorchidismDeborah Lo Giacco
Andrology Service, Molecular Biology Laboratory, Fundacio Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain
Fertil Steril 95:369-71, 371.e1-2. 2011..In a case-control study, we were unable to demonstrate any association between (TA)n and nonsyndromic cryptorchidism in Italian and Spanish study populations.
- Risk factors for cryptorchism among populations at differing risks of testicular cancerKatherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Int J Epidemiol 35:787-95. 2006..However, while TGCT incidence varies greatly between white and black men, little variability has been reported between the two groups in cryptorchism prevalence. This may suggest that cryptorchism risk factors differ by ethnicity...
- Sperm count of young men surgically treated for cryptorchidism in the first and second year of life: fertility is better in children treated at a younger ageF Canavese
Department of Pediatric Surgery, Regina Margherita Children s Hospital, Piazza Polonia 94, Turin, Italy
Eur J Pediatr Surg 19:388-91. 2009..In this study, we evaluated testicular function in young men operated on for cryptorchidism in the first year of life. To our knowledge, this is the first report on the effects of such an early treatment...
- Trends in the incidence of cryptorchidism and hypospadias of registry-based data in Korea: a comparison between industrialized areas of petrochemical estates and a non-industrialized areaSae Chul Kim
Department of Urology, Chung Ang University College of Medicine, Seoul 156 756, Korea
Asian J Androl 13:715-8. 2011This study aimed to represent the recent trends in the nationwide incidence of cryptorchidism and hypospadias in Korea, and to determine whether there is evidence of spatial heterogeneity in the incidence...
- Cryptorchidism: pathogenesis, diagnosis, treatment and prognosisRichard A Ashley
Nemours Alfred I duPont Hospital for Children, Division of Pediatric Urology, Wilmington, DE 19803 3607, USA
Urol Clin North Am 37:183-93. 2010b>Cryptorchidism is a common genital anomaly diagnosed at birth or during childhood...
- Nordic consensus on treatment of undescended testesE Martin Ritzen
Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
Acta Paediatr 96:638-43. 2007..To reach consensus among specialists from the Nordic countries on the present state-of-the-art in treatment of undescended testicles...
- Prospective study on the prevalence and associated risk factors of cryptorchidism in 6246 newborn boys from Nice area, FranceK Wagner-Mahler
Pediatrics Department, CHU Nice, Nice, France Conseil Général Des Alpes Maritimes, Nice, France
Int J Androl 34:e499-510. 2011To assess the incidence and risk factors of cryptorchidism in Nice area. A 3-year prospective study was conducted at two maternity wards involving neonatal screening of boys born ≥34weeks of amenorrhoea...
- Unilateral cryptorchidism in mice mutant for PtgdsPascal Philibert
Département d Hormonologie, Hopital Lapeyronie, CHU de Montpellier et Université Montpellier 1, Montpellier, France
Hum Mutat 34:278-82. 2013The pathophysiology of cryptorchidism, abnormal testicular descent, remains poorly understood...
- Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadiasR Cassata
Physiopathology and Reproduction, Faculty of Veterinary Medicine, University Federico II, Naples, Italy
Cytogenet Genome Res 120:140-3. 2008The aim of this study was to estimate prognostic factors in a Dalmatian dog with bilateral cryptorchidism and hypospadias...
- Homeobox HOXA10 gene analysis in cryptorchidismVeronica Bertini
Cytogenetic and Molecular Biology Unit, Santa Chiara Hospital, Pisa, Italy
J Pediatr Endocrinol Metab 17:41-5. 2004In male mice, targeted disruption of the homeobox gene hoxa10 causes cryptorchidism and infertility. Genetic alterations in exon 1 of HOXA10 have been found in a high number of boys with cryptorchidism.
- ORGANOCHLORINE PESTICIDES AND MALE GENITAL ANOMALIESRajiv Bhatia; Fiscal Year: 2002..The Investigators propose a nested case-control study of cryptorchidism and hypospadias and in utero exposure to DDT within the Child Health and Development Studies (CHDS) cohort...
- The Mechanism of Cryptorchidism in LH Receptor Knockout AnimalsZhenmin Lei; Fiscal Year: 2012DESCRIPTION (provided by applicant): Cryptorchidism is by far the most common defect of sexual differentiation in humans. Testicular descent can be anatomically divided into two stages, i.e., transabdominal and inguinoscrotal phases...
- Phthalate Exposure and Pregnancy OutcomeT Peter Stein; Fiscal Year: 2010..duration together with the incidence of birth defects, particularly male urogenital defects including cryptorchidism and hypospadias...
- Epidemiology of testicular cancer in the Utah populationMia Hashibe; Fiscal Year: 2012..The well-established testicular cancer risk factors include age, contralateral testicular cancer, cryptorchidism, race/ethnicity and family history of testicular cancer...
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010..The incidence of testicular cancer has increased and semen quality has decreased, and the incidences of cryptorchidism and hypospadias appear to have increased in certain regions...
- Phthalates in Drugs and Male Genital MalformationAllen A Mitchell; Fiscal Year: 2012..Prenatal exposure of male rats to DBP and DEHP has been shown to produce cryptorchidism and hypospadias, presumably due to their anti-androgenic activity...
- Genetics and the Environment Associated with Male Reproduction (GEAR)Sheela Sathyanarayana; Fiscal Year: 2012..provided by applicant): In specific areas of industrialized nations, the rising incidence of hypospadias and cryptorchidism from 1950- 2000 parallels the production and use of some phthalates, anti-androgenic synthetic chemicals used ..
- Disorders of Sex Development: Platform for Basic and Translational ResearchERIC J VILAIN; Fiscal Year: 2013..sex development (DSD) are phenotypically heterogeneous, ranging from minor genital malformations (hypospadias, cryptorchidism, hypertrophy of the clitoris) to genital ambiguity...
- Translational control during fetal male germ cell developmentCHRIS BENNETT GEYER; Fiscal Year: 2012..dysgenesis syndrome, a spectrum of male reproductive disorders such as carcinoma in situ, testicular cancer, cryptorchidism, and hypospadia that originate during this fetal period of germ cell development...
- Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine DisruptionKim Boekelheide; Fiscal Year: 2013..the observed abnormalities-including malformed external genitalia (hypospadias), undescended testis (cryptorchidism), spermatogenic defects, and testis germ cell cancer-result from alterations in the in utero and perinatal ..
- A Genetic Linkage Study of Testicular CancerVictoria Cortessis; Fiscal Year: 2009..risk factors are family history of testis cancer (relative risk of 10 for brothers) and a personal history of cryptorchidism or congenitally undescended testicles (relative risk 2.5-18)...
- Genetic Basis of CryptorchidismJulia Spencer Barthold; Fiscal Year: 2012DESCRIPTION (provided by applicant): Cryptorchidism is a common congenital anomaly with evidence for multilocus genetic contribution...
- Gene Networks in Peri-pubertal Sertoli Cell InjuryMary L Hixon; Fiscal Year: 2010..registry surveys demonstrate that altered intrauterine growth increases the risks of congenital hypospadias, cryptorchidism and testicular cancer approximately 2- to 3-fold...
- EPIDEMIOLOGY OF MALE INFERTILITY: CRYPTORCHIDISMPeter Lee; Fiscal Year: 1999b>Cryptorchidism is a major, but poorly studied, cause of male infertility...
- INFECTIOUS ETIOLOGY TESTICULAR CANCERLoren Lipworth; Fiscal Year: 2000The trend of increasing testicular cancer incidence is unlikely to be explained by known risk factors such as cryptorchidism. An infectious etiology of testicular cancer has been proposed, based on similarities between the age-specific ..
- REGULATION OF TESTICULAR BLOOD FLOWClaude Desjardins; Fiscal Year: 1993..reproductive health because it provides a framework for investigating the unknown etiology of testicular vascular disorders (varicocele, orchitis, and cryptorchidism), the most prominent source of testicular dysfunction and infertility.
- Murine Atlas of Genitourinary Smooth Muscle DevelopmentJAMES LESSARD; Fiscal Year: 2009..e. hypospadias and cryptorchidism) are increasing...
- PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53Kim Boekelheide; Fiscal Year: 2007..the observed abnormalities-including malformed external genitalia (hypospadias), undesecended testis (cryptorchidism), spermatogenic defects, and testis germ cell cancer- result from the alterations in the in utero and ..
- Insulin-3 in Human Testicular Disease and as a Therapeutic AgentLinda Baker; Fiscal Year: 2009..This is likely due to abnormal testicular development. In addition, cryptorchidism, the absence of the testicle from the scrotum, is the most common genital anomaly of male infants affecting 3% ..
- PREVALENCE & EPIDEMIOLOGY OF CRYPTORCHIDISMGertrud Berkowitz; Fiscal Year: 1991The overall objectives of this proposal are to determine the prevalence rate of true cryptorchidism during early infancy and to assess the role of maternal and gestational factors in the epidemiology of cryptorchidism...
- Molecular Mechanisms of Wnt4 Action in Developing GonadAlice Fleming; Fiscal Year: 2006..Male patients with duplications in Wnt4 exhibit sexual phenotypes ranging from cryptorchidism to XY sex reversal...
- DIETHYLSTILBESTROL AND TESTICULAR CANCER IN CONNECTICUTJohn Lewis; Fiscal Year: 1980..Drug histories will be obtained from hospital records and from prenatal records of mothers. Other factors to be evaluated include exposure to other exogenous estrogens in utero, cryptorchidism, and hypoplastic testes.
- Biological Role of a Novel Testis Insulin-Like ProteinRam Menon; Fiscal Year: 2004..Furthermore, the recent discovery of the cognate receptor (LGR8) for Insl3 and the elucidation of cryptorchidism as one of components of the LGR8 null phenotype underscore the exciting advances made in this field...
- MOLECULAR EPIDEMIOLOGY OF TESTICULAR CARCINOMAStephen Schwartz; Fiscal Year: 2009..The findings from this study will add new information regarding the epidemiology and etiology of TGCC, and will serve as a resource for future investigations of the interplay of genetic and non-genetic factors in these malignancies. ..
- PREVENTIVE ONCOLOGY ACADEMIC AWARDSLisa Herrinton; Fiscal Year: 2000..Does surgical correction of cryptorchidism (orchidopexy) at a relatively young age reduce the risk of germ-cell testicular cancer to a greater extent ..
- Fetal Basis of Sexual Dysfunction: Brain DifferentiationD N Rao Veeramachaneni; Fiscal Year: 2007..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..
- Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular CellsD N Rao Veeramachaneni; Fiscal Year: 2007..Our long-term goal is to delineate molecular mechanisms underlying cryptorchidism and transformation of testicular cells into precancerous cells...
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2009..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- Inhibition of Pancreatic Cancer by New PPARgamma Agonis*Stephen Safe; Fiscal Year: 2008..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
- AUTOSOMAL MECHANISMS OF TESTIS INDUCTIONVICKI MEYERS WALLEN; Fiscal Year: 2005..At the end of this grant period, we will have identified the gene causing this disorder and the step in the testis pathway that is altered by the mutation in timing, quantity, or location of gene expression. ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- Immunity to brain Ma proteins: A remote effect of cancerJosep Dalmau; Fiscal Year: 2007..abstract_text> ..
- Comparative Effectiveness of Treatments for Localized Prostate CancerDavid F Penson; Fiscal Year: 2010..By figuring out what treatments "work best, in which patients and in whose hands", we will help men with prostate cancer make better decisions regarding their care. ..
- A Preclinical Model of Adolescent Toluene Abuse in RatsScott Bowen; Fiscal Year: 2005..The model also has the potential to assist in devising effective treatments and prevention strategies for adolescent inhalant abuse. ..
- Self-administration of abused inhalants in miceScott Bowen; Fiscal Year: 2004....
- Testicular Torsion: Mechanisms and TreatmentTerry Turner; Fiscal Year: 2005..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..
- RELAXIN-LIKE FACTOR IN MALE GONADAL DEVELOPMENTChristian Schwabe; Fiscal Year: 2005..the role RLF is playing in these processes and will significantly improve the prospects for a drug to treat cryptorchidism. We intend to use specially designed synthetic RLF derivatives and anti-RLF antibodies to study the process of ..
- Modulation of Insulin Action by Testosterone in MenNelly Pitteloud; Fiscal Year: 2010..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
- Aging and Function of Stem Leyding CellsRen Shan Ge; Fiscal Year: 2010....
- Dietary Glycemic Load, Obesity, and Birth Defect RisksMartha Werler; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- The Role of Hormone Polymorphisms in Menstrual Function and FertilityCHANLEY SMALL; Fiscal Year: 2008..The proposed pilot study is an efficient use of existing data and biological specimens to explore these relationships among a subset of important genes in reproductive function. [unreadable] [unreadable] [unreadable]..
- Race, Comorbidity & Long Term Prostate Cancer OutcomesDavid Penson; Fiscal Year: 2009..Specifically, it will help newly-diagnosed patients make more informed decisions regarding treatment and will help researchers design novel interventions to improve the quality of life of prostate cancer survivors. ..
- New York State Angler Cohort Follow-up StudyMatthew Bonner; Fiscal Year: 2009..abstract_text> ..
- Targeting Relaxin Signaling in Prostate CancerAlexander Agoulnik; Fiscal Year: 2008..Demonstartion of the anti- tumor activity of RLN signaling supression may provide a novel target for therapeutical intervention in this deadly disease. ..
- Paraneoplastic Disorders of CNS: Autoantigen ProfilingJosep Dalmau; Fiscal Year: 2007..unreadable] [unreadable]..
- Longterm Quality of Life of Prostate Cancer SurvivorsDavid Penson; Fiscal Year: 2006..This, in turn, will aid in clinical decision making and assist in designing interventions to improve outcomes in prostate cancer survivors. ..
- Maternal Vasoactive Exposures and Risk of ClubfootMartha M Werler; Fiscal Year: 2010..Buccal cell swabs will be collected from cases, controls, and their mothers. DNA will be extracted and stored for the purpose of studying genetic risk factors in future studies. ..
- Behavioral Effects of Gestational Inhalant Abuse in RatsScott Bowen; Fiscal Year: 2006..Finally, this research has the potential to assist in the design of effective treatments for inhalant abuse. [unreadable] [unreadable]..
- Calorie Restriction Effects on Chromosomal AberrationsCHARLEEN MOORE; Fiscal Year: 2003..The results will be essential in identifying potential mechanisms by which CR acts in cancer prevention and delay of the aging process in long-lived species such as the rhesus monkey and humans. ..