cystitis

Summary

Summary: Inflammation of the urinary bladder. (Dorland, 27th ed)

Top Publications

  1. ncbi International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases
    Kalpana Gupta
    Department of Medicine, Veterans Affairs Boston Health Care System, Boston University School of Medicine, Boston, Massachusetts, USA
    Clin Infect Dis 52:e103-20. 2011
  2. ncbi Urinary MMP-9/NGAL complex in children with acute cystitis
    Sami Hatipoglu
    Department of Pediatrics, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
    Pediatr Nephrol 26:1263-8. 2011
  3. pmc Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association
    Pedro L Vera
    Bay Pines VA Healthcare System, Research and Development 151, Bay Pines, Florida, USA
    PLoS ONE 3:e3898. 2008
  4. ncbi Voided stain on paper method for analysis of mouse urination
    Y Sugino
    Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neurourol Urodyn 27:548-52. 2008
  5. ncbi Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis
    M A Vizzard
    Department of Anatomy and Neurology, University of Vermont College of Medicine, E219 Given Building, Burlington, VT 05405, USA
    J Chem Neuroanat 21:125-38. 2001
  6. pmc Regulation of IGF-1 but not TGF-β1 by NGF in the smooth muscle of the inflamed urinary bladder
    Qing L Zhang
    Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States
    Regul Pept 177:73-8. 2012
  7. pmc Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis
    Marc C Smaldone
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Urology 73:421-6. 2009
  8. ncbi Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 19:1395-401. 2006
  9. ncbi papG alleles of Escherichia coli strains causing first-episode or recurrent acute cystitis in adult women
    J R Johnson
    University of Minnesota and VA Medical Center, Minneapolis 55417, USA
    J Infect Dis 177:97-101. 1998
  10. pmc Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons
    Sharon J Yu
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Mol Pain 8:48. 2012

Research Grants

Detail Information

Publications302 found, 100 shown here

  1. ncbi International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases
    Kalpana Gupta
    Department of Medicine, Veterans Affairs Boston Health Care System, Boston University School of Medicine, Boston, Massachusetts, USA
    Clin Infect Dis 52:e103-20. 2011
    ..The focus of this work is treatment of women with acute uncomplicated cystitis and pyelonephritis, diagnoses limited in these guidelines to premenopausal, non-pregnant women with no known ..
  2. ncbi Urinary MMP-9/NGAL complex in children with acute cystitis
    Sami Hatipoglu
    Department of Pediatrics, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
    Pediatr Nephrol 26:1263-8. 2011
    ..Identification of NGAL-MMP-9/cr levels in the urine of suspected UTI patients may also be useful to differentiate between contamination and infection and for monitoring of treatment response in children...
  3. pmc Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association
    Pedro L Vera
    Bay Pines VA Healthcare System, Research and Development 151, Bay Pines, Florida, USA
    PLoS ONE 3:e3898. 2008
    Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro...
  4. ncbi Voided stain on paper method for analysis of mouse urination
    Y Sugino
    Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neurourol Urodyn 27:548-52. 2008
    ..To evaluate the usefulness of a quantification method using filter paper for analyzing minute voided urine of the mouse...
  5. ncbi Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis
    M A Vizzard
    Department of Anatomy and Neurology, University of Vermont College of Medicine, E219 Given Building, Burlington, VT 05405, USA
    J Chem Neuroanat 21:125-38. 2001
    ..peptide (CGRP) and substance P (SP) in lumbosacral (L6-S1) micturition reflex pathways, following chronic cystitis induced by cyclophosphamide (CYP)...
  6. pmc Regulation of IGF-1 but not TGF-β1 by NGF in the smooth muscle of the inflamed urinary bladder
    Qing L Zhang
    Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States
    Regul Pept 177:73-8. 2012
    Intraperitoneal injection of cyclophosphamide (CYP) causes hemorrhagic cystitis with excess growth of muscular layer leading to bladder hypertrophy; this could be attributable to changes in the expression profiles of growth factors in the ..
  7. pmc Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis
    Marc C Smaldone
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Urology 73:421-6. 2009
    ..is a potential easily accessible source of biomarkers for inflammatory bladder diseases, including interstitial cystitis. In the present study, we subjected rat urine to multiplex cytokine analysis in an attempt to identify an ..
  8. ncbi Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 19:1395-401. 2006
    ..Tissues from 46 patients, including 22 cases of intestinal metaplasia of the urinary bladder, 11 cases of typical cystitis glandularis, and 13 cases containing both lesions, were selected and immunohistochemical stains for CDX2, Hep, ..
  9. ncbi papG alleles of Escherichia coli strains causing first-episode or recurrent acute cystitis in adult women
    J R Johnson
    University of Minnesota and VA Medical Center, Minneapolis 55417, USA
    J Infect Dis 177:97-101. 1998
    ..classes I-III) was assessed among 74 Escherichia coli urine isolates from women with first-episode or recurrent cystitis, and papG genotype was compared with clinical origin, O serogroup, agglutination of Gal(alpha1-4)Gal-coated latex ..
  10. pmc Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons
    Sharon J Yu
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Mol Pain 8:48. 2012
    b>Cystitis causes considerable neuronal plasticity in the primary afferent pathways...
  11. ncbi The effects of sacral acupuncture on acetic acid-induced bladder irritation in conscious rats
    Kokoro Hino
    Department of Clinical Acupuncture and Moxibustion, Meiji University of Integrative Medicine, Hiyoshi cho, Nantan, Kyoto, Japan
    Urology 75:730-4. 2010
    ..To investigate the effects of sacral acupuncture on acetic acid-induced bladder irritation using cystometry in conscious rats, with particular focus on effects on afferent fibers of the bladder...
  12. pmc A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131
    Makrina Totsika
    Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Australia
    J Infect Dis 208:921-8. 2013
    ..Urinary tract infections (UTIs) caused by E. coli ST131 are typically associated with limited treatment options and are often recurrent...
  13. ncbi Decrease of Trefoil factor 2 in cats with feline idiopathic cystitis
    Stephanie I K Lemberger
    Clinic of Small Animal Medicine, Department of Veterinary Sciences, LMU University of Munich, Germany
    BJU Int 107:670-7. 2011
    To obtain new insights into aetiological backgrounds, and to search for diagnostic biomarkers by assessing the difference in urinary proteins between cats with spontaneous feline idiopathic cystitis (FIC) and healthy controls.
  14. ncbi Bladder permeability barrier: recovery from selective injury of surface epithelial cells
    John Lavelle
    Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Renal Physiol 283:F242-53. 2002
    ..this barrier is damaged, leakage of urine components into the underlying bladder layers results, with symptoms of cystitis. In these studies, we develop a model of selective urothelial injury using protamine sulfate (PS) and define the ..
  15. pmc Mast cell-derived histamine mediates cystitis pain
    Charles N Rudick
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 3:e2096. 2008
    ..Interstitial cystitis (IC) is a bladder disease that causes debilitating pelvic pain of unknown origin and without consistent ..
  16. ncbi Emphysematous cystitis: illustrative case report and review of the literature
    Moti Grupper
    Infectious Diseases and Urology, Bnai Zion Medical Center and the Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Medicine (Baltimore) 86:47-53. 2007
    Emphysematous cystitis is a rare disease characterized by primary infection of the urinary bladder with gas-producing pathogens...
  17. ncbi Bilateral emphysematous pyelonephritis and emphysematous cystitis with autosomal-dominant polycystic kidney disease: is conservative management justified?
    Narayanaswamy Arun
    Departments of Surgery Urology Unit and Nephrology, Al Amiri Hospital, Kuwait
    Med Princ Pract 16:155-7. 2007
    To report a case of bilateral emphysematous pyelonephritis (EPN) and emphysematous cystitis in a 64-year-old diabetic male with autosomal-dominant polycystic kidney disease (ADPKD).
  18. ncbi The role of beta-catenin signaling in the malignant potential of cystitis glandularis
    R T Bryan
    Epithelial Laboratory, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    J Urol 170:1892-6. 2003
    ..b>Cystitis glandularis is a metaplastic lesion of the bladder urothelium occurring in the presence of chronic inflammation ..
  19. ncbi Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation
    Hiroshi Kiuchi
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    J Urol 181:2339-48. 2009
    ..Sigma) is associated with urological complications, including irritative voiding symptoms and hemorrhagic cystitis. Evidence suggests that tumor necrosis factor-alpha (R&D Systems), interleukin-1beta and cyclooxygenase-2 are ..
  20. ncbi Comparison of uroprotective efficacy of mesna and amifostine in Cyclophosphamide- induced hemorrhagic cystitis in rats
    Ozkan Kanat
    Uludag University, Faculty of Medicine, Department of Medical Oncology, Gorukle 16059, Bursa, Turkey
    Indian J Cancer 43:12-5. 2006
    Hemorrhagic cystitis (HC) is a dose limiting side effect of cyclophosphamide (CYP).
  21. ncbi Antibiotics versus placebo in the treatment of women with uncomplicated cystitis: a meta-analysis of randomized controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Infect 58:91-102. 2009
    Acute uncomplicated cystitis is one of the most common bacterial infections in women and is conventionally treated with antibiotics...
  22. pmc Cystitis increases colorectal afferent sensitivity in the mouse
    Pablo Rodolfo Brumovsky
    Center for Pain Research, Departments of Anesthesiology, University of Pittsburgh, Pennsylvania, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1250-8. 2009
    ..and rodents suggest that colon inflammation promotes urinary bladder hypersensitivity and, conversely, that cystitis contributes to colon hypersensitivity, events referred to as cross-organ sensitization...
  23. ncbi Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis
    Paulo Dinis
    Institute of Histology and Embryology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    J Neurosci 24:11253-63. 2004
    ..Animals were given intraperitoneal cyclophosphamide injection, which evokes painful hemorrhagic cystitis accompanied by increased bladder reflex activity...
  24. ncbi Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients
    Ashley N Miller
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Biol Blood Marrow Transplant 17:1176-81. 2011
    Polyoma virus BK-induced hemorrhagic cystitis is an important cause of morbidity after hematopoietic stem cell transplantation (HSCT)...
  25. ncbi Acute acrolein-induced cystitis in mice
    Dale E Bjorling
    Department of Surgical Sciences, School of Veterinary, University of Wisconsin, Madison, WI 53706, USA
    BJU Int 99:1523-9. 2007
    To develop a method of direct intravesical administration of acrolein and evaluate the severity of cystitis in response to increasing doses of acrolein in female C57BL/6N (C57) mice, with further studies to compare the severity of acute ..
  26. pmc Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis
    Chul Won Chung
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0551, USA
    J Biol Chem 285:4206-12. 2010
    ..We reported here that cyclophosphamide (CYP)-induced cystitis significantly increased the production of type I collagen in the inflamed bladder leading to increases in the ..
  27. ncbi Fosfomycin versus other antibiotics for the treatment of cystitis: a meta-analysis of randomized controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    J Antimicrob Chemother 65:1862-77. 2010
    b>Cystitis is a common infection. The alarmingly high resistance rates exhibited by contemporary uropathogens necessitate the re-evaluation of old antibiotics.
  28. pmc PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 36:310-20. 2008
    ..To gain insight into PACAP signaling in micturition and regulation with cystitis, receptor characterization by real-time quantitative polymerase chain reaction and physiological assays were ..
  29. ncbi Assessment of murine bladder permeability with fluorescein: validation with cyclophosphamide and protamine
    L Eichel
    Department of Urology, University of Rochester School of Medicine, Rochester, New York, USA
    Urology 58:113-8. 2001
    ..NaF) were measured in mice before and during cyclophosphamide (CYP) and protamine-induced hemorrhagic cystitis. METHODS: To measure the plasma uptake of NaF from the bladder, 10 mg/mL NaF was instilled, either by catheter or ..
  30. ncbi Eosinophilic cystitis in adults
    N M Itano
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Urol 165:805-7. 2001
    ..the largest clinical experience with the diagnosis and management of largely anecdotally reported eosinophilic cystitis. MATERIALS AND METHODS: Five women and 12 men 18 to 84 years with proved eosinophilic cystitis were treated in a ..
  31. ncbi A model of hemorrhagic cystitis induced with acrolein in mice
    C K L P Batista
    Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil
    Braz J Med Biol Res 39:1475-81. 2006
    ..metabolite of cyclophosphamide and ifosfamide, which has been reported to be the causative agent of hemorrhagic cystitis induced by these compounds. A direct cytotoxic effect of acrolein, however, has not yet been demonstrated...
  32. ncbi GAG layer replenishment therapy for chronic forms of cystitis with intravesical glycosaminoglycans--a review
    Helmut Madersbacher
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Neurourol Urodyn 32:9-18. 2013
    Glycosaminoglycan (GAG) layer replenishment is a cornerstone in the therapy of interstitial cystitis (IC)...
  33. pmc The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice
    J P Martins
    Faculdade de Medicina, PUCRS, Porto Alegre, RS, Brazil
    Br J Pharmacol 165:183-96. 2012
    ..Haemorrhagic cystitis (HC) is a well-known adverse effect of therapy with cyclophosphamide used for the treatment of many solid tumours ..
  34. pmc Models of inflammation of the lower urinary tract
    Dale E Bjorling
    Department of Surgical Sciences, University of Wisconsin Madison, Madison, WI, USA
    Neurourol Urodyn 30:673-82. 2011
    ..discuss various animal models of lower urinary tract inflammation, including feline spontaneous (interstitial) cystitis, neurogenic cystitis, autoimmune cystitis, cystitis induced by intravesical instillation of chemicals or ..
  35. ncbi Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladder
    Shu Mien Chuang
    Yuh Ing Junior College of Health Care and Management, Kaohsiung, Taiwan
    Neurourol Urodyn 32:1137-43. 2013
    ..The aims of the present study were to investigate voiding patterns, tissue constituents and the expressions of cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS) involved in ketamine-induced ulcerative cystitis in rat urinary bladder.
  36. pmc Comparison of Escherichia coli strains recovered from human cystitis and pyelonephritis infections in transurethrally challenged mice
    D E Johnson
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 66:3059-65. 1998
    ..coli induces pyelonephritis has accumulated. Although cystitis accounts for 95% of visits to physicians for symptoms of urinary tract infections, few in vivo studies have ..
  37. pmc Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis
    Lauren Arms
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Renal Physiol 301:F252-62. 2011
    ..These results demonstrate increased AKT phosphorylation in the urinary bladder with urinary bladder inflammation and that blockade of AKT phosphorylation in the urothelium improves overall bladder function...
  38. ncbi Diagnosis and treatment of acute uncomplicated cystitis
    Richard Colgan
    University of Maryland School of Medicine, Baltimore, USA
    Am Fam Physician 84:771-6. 2011
    ..Most urinary tract infections are acute uncomplicated cystitis. Identifiers of acute uncomplicated cystitis are frequency and dysuria in an immunocompetent woman of ..
  39. ncbi Cystitis glandularis in children
    Nicola Capozza
    Division of Paediatric Urology, Bambino Gesu Children s Hospital, Research Institute, Piazza S Onofrio, 4 00165, Rome, Italy
    BJU Int 95:411-3. 2005
    To assess the characteristics of cystitis glandularis in children.
  40. ncbi Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant
    M R Savona
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Bone Marrow Transplant 39:783-7. 2007
    ..of hematopoietic stem cell transplants (HSCTs), BK virus (BKV) has been associated with late-onset hemorrhagic cystitis (HC). In our institution, HSCT recipients with BKV-associated HC are treated with 1 mg/kg of cidofovir weekly...
  41. ncbi Altered muscarinic receptor subtype expression and functional responses in cyclophosphamide induced cystitis in rats
    D Giglio
    Department of Pharmacology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Auton Neurosci 122:9-20. 2005
    ..the expression of muscarinic receptors and cholinergic responses were altered in the situation of experimental cystitis. Rats were treated with cyclophosphamide intraperitoneally and the bladders were excised 36-100 h later...
  42. ncbi Emphysematous cystitis in the absence of known risk factors: an unusual clinical entity
    Theodoros Kelesidis
    Department of Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    South Med J 102:942-6. 2009
    Emphysematous cystitis is a rare disorder that is usually associated with immunosuppression, poorly controlled diabetes mellitus, and other risk factors such as previous urinary tract infection and/or recent instrumentation of the urinary ..
  43. pmc RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model
    Wujiang Liu
    Department of Urology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, 3202 MERF, 375 Newton Road, IA 52242 1087, USA
    J Autoimmun 30:257-65. 2008
    Interstitial cystitis (IC) is a chronic inflammatory condition of the urinary bladder with a strong autoimmune component. Currently, the major challenge in IC treatment is the development of effective therapies...
  44. ncbi Acute uncomplicated cystitis: from surveillance data to a rationale for empirical treatment
    Ioannis Katsarolis
    4th Department of Internal Medicine, Attikon University General Hospital, 1 Rimini Avenue, 12462 Haidari, Athens, Greece
    Int J Antimicrob Agents 35:62-7. 2010
    ..the epidemiological features and resistance rates in uropathogens isolated from cases of acute uncomplicated cystitis (AUC) in Greece, and subsequently to guide empirical treatment...
  45. ncbi Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis
    Ana Charrua
    Institute of Histology and Embryology, Faculty of Medicine, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal
    J Urol 177:1537-41. 2007
    We evaluated the role of transient receptor potential vanilloid subfamily 1 for the generation of noxious bladder input and bladder overactivity associated with cystitis.
  46. ncbi Choice of antibiotic for empirical therapy of acute cystitis in a setting of high antimicrobial resistance
    Debasis Biswas
    Department of Microbiology, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Jolly Grant, Dehradun, India
    Indian J Med Sci 60:53-8. 2006
    ..A high prevalence of antimicrobial resistance among urinary isolates in the Garhwal region of Uttaranchal...
  47. ncbi Antimicrobial resistance among uropathogens that cause acute uncomplicated cystitis in women in Hong Kong: a prospective multicenter study in 2006 to 2008
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 66:87-93. 2010
    ..was conducted to assess the epidemiology of antimicrobial resistance among uropathogens causing uncomplicated cystitis. Adult women with clinical diagnosis of uncomplicated cystitis were enrolled from 54 participating centers ..
  48. ncbi Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon
    O Ringden
    Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Leukemia 21:2271-6. 2007
    ..Their median age was 48 (13-64) years. Seven had hemorrhagic cystitis grades 2-5, two had pneumomediastinum and one had perforated colon and peritonitis...
  49. ncbi Genotypic characterization of virulence factors in Escherichia coli strains from patients with cystitis
    Monique Ribeiro Tiba
    Departamento de Microbiologia e Imunologia, Laboratório de Antígenos Bacterianos II, Instituto de Biologia, Universidade Estadual de Campinas, Cidade Universitaria Zeferino Vaz, Campinas, SP, Brasil
    Rev Inst Med Trop Sao Paulo 50:255-60. 2008
    ..In this work, 162 Uropathogenic Escherichia coli (UPEC) strains from patients with cystitis were genotypically characterized by polymerase chain reaction (PCR) assay...
  50. pmc BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients
    Veronique Erard
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Program in Infectious Diseases, 1100 Fairview Ave North D3 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 106:1130-2. 2005
    We performed a case-control study to determine the association of BK plasma viremia with hemorrhagic cystitis (HC) in hematopoietic cell transplant (HCT) recipients...
  51. ncbi Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice
    Zun Yi Wang
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53719, USA
    Pain 139:158-67. 2008
    ..The effects of experimental cystitis on bladder function (an indicator of visceral pain) and the threshold of response to mechanical or thermal ..
  52. ncbi Maternal use of cystitis medication and childhood epilepsy in a danish population-based cohort
    Jessica E Miller
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Paediatr Perinat Epidemiol 26:589-95. 2012
    ..We examined cystitis antibiotics commonly used during pregnancy, as a marker of cystitis, and the risk of childhood epilepsy in a ..
  53. ncbi Unique BK virus non-coding control region (NCCR) variants in hematopoietic stem cell transplant recipients with and without hemorrhagic cystitis
    Michael J Carr
    Department of Clinical Microbiology, Trinity Centre for Health Sciences, University of Dublin, Trinity College, St James s Hospital, Dublin, Ireland
    J Med Virol 78:485-93. 2006
    Hematopoietic stem cell transplant recipients frequently develop BK virus (BKV)-associated hemorrhagic cystitis, which coincides with BK viruria...
  54. ncbi Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats
    Katsuaki Ito
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki, 889 2192, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:483-90. 2008
    ..effect of the recently developed P2X3 and P2X2/3 receptor antagonist A-317491 on cyclophosphamide (CYP)-induced cystitis to determine whether a P2X receptor antagonist could be beneficial for the treatment of bladder overactivity ..
  55. pmc Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains
    W J Hopkins
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 43792, USA
    Infect Immun 66:2798-802. 1998
    ..The latter result strongly suggests that the presence or absence of specific host genes will determine how effectively an E. coli UTI will be resolved...
  56. pmc Association between a high BK virus load in urine samples of patients with graft-versus-host disease and development of hemorrhagic cystitis after hematopoietic stem cell transplantation
    G Bogdanovic
    Department of Oncology Pathology, Karolinska Institute, Hudding University Hospital, Stockholm, Sweden
    J Clin Microbiol 42:5394-6. 2004
    ..alone or in combination with acute graft-versus-host disease (GVHD) was correlated to development of hemorrhagic cystitis (HC)...
  57. ncbi Diagnostic significance of clinical and laboratory findings to localize site of urinary infection
    Eduardo H Garin
    Department of Pediatrics, University of Florida, P O Box 100296, Gainesville, FL, 32610, USA
    Pediatr Nephrol 22:1002-6. 2007
    ..Patients were divided into having either acute pyelonephritis or acute cystitis according to the presence or absence of acute lesions on dimercaptosuccinic acid (DMSA) renal scintigraphy...
  58. ncbi [Clinical aspects and epidemiology of uncomplicated cystitis in women. German results of the ARESC Study]
    F M E Wagenlehner
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Giessen und Marburg Standort Giessen
    Urologe A 49:253-61. 2010
    Uncomplicated cystitis in women is among the most frequent infections in the community setting...
  59. pmc Calcifying nanoparticles associated encrusted urinary bladder cystitis
    Tomislav M Jelic
    Department of Pathology, CAMC, Memorial Hospital, 3200 MacCorkle Avenue, Charleston, WV 25304, USA
    Int J Nanomedicine 3:385-90. 2008
    Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers...
  60. pmc Role of human papillomavirus types 16, 18, and 52 in recurrent cystitis and urinary bladder cancer among Egyptian patients
    Hala Badawi
    Infection Control Unit, Theodor Bilharz Research Institute TBRI, Giza, Egypt
    Medscape J Med 10:232. 2008
    ..We aimed to estimate the prevalence of HPV-16, -18, and -52 in Egyptian patients with bladder cancer or recurrent cystitis, and to study the correlation of type-specific HPV-immunoglobulin (Ig)G with polymerase chain reaction (PCR) ..
  61. ncbi Decreased nanobacteria levels and symptoms of nanobacteria-associated interstitial cystitis/painful bladder syndrome after tetracycline treatment
    Qing Hua Zhang
    Urological Research Institute of PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, People s Republic of China
    Int Urogynecol J 21:103-9. 2010
    ..to detect whether nanobacteria (NB) reside in urine and bladder tissue samples of patients with interstitial cystitis/painful bladder syndrome (IC/PBS) and whether antibiotic therapy targeting these organisms is effective in ..
  62. ncbi Changes in galanin immunoreactivity in rat micturition reflex pathways after cyclophosphamide-induced cystitis
    K Zvarova
    Departments of Neurology and Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Cell Tissue Res 324:213-24. 2006
    ..neuropeptide, galanin, were examined in micturition reflex pathways of rat after cyclophosphamide (CYP)-induced cystitis of variable duration: acute (4 h), intermediate (48 h), or chronic (10 days)...
  63. pmc Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats
    Simone D Guerios
    Department of Surgical Sciences, School of Veterinary Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 295:R111-22. 2008
    ..b>Cystitis may induce transient or persistent plastic changes mediated by neurotrophins, particularly nerve growth factor (..
  64. ncbi Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis
    R Pinto
    Instituto de Biologia Celular e Molecular, Porto, Portugal Department of Urology, Hospital de S Joao, Porto, Portugal
    Neuroscience 166:907-16. 2010
    ..It is upregulated in various inflammatory conditions, where it may contribute to altered pain states. In cystitis, little is known about the relevance of BDNF in bladder-generated noxious input and bladder overactivity, a ..
  65. pmc Serotonergic and noradrenergic facilitation of the visceromotor reflex evoked by urinary bladder distension in rats with inflamed bladders
    Alan Randich
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neurosci Lett 442:253-6. 2008
    ....
  66. pmc Cholinergic nitric oxide release from the urinary bladder mucosa in cyclophosphamide-induced cystitis of the anaesthetized rat
    M C Andersson
    Department of Pharmacology, The Sahlgrenska Academy at Goteborg University, Gothenburg, Sweden
    Br J Pharmacol 153:1438-44. 2008
    ..that nitric oxide (NO) may be released by cholinergic stimuli in the rat bladder in cyclophosphamide-induced cystitis, affecting bladder function...
  67. pmc Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis
    Wouter Everaerts
    Laboratory of Ion Channel Research, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 107:19084-9. 2010
    ..micturition frequency (pollakisuria) are common lower urinary tract symptoms associated with conditions such as cystitis, prostatic hyperplasia, neurological disease, and overactive bladder syndrome...
  68. ncbi Uroprotective effects of curcumin in cyclophosphamide-induced haemorrhagic cystitis paradigm
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Basic Clin Pharmacol Toxicol 104:393-9. 2009
    The possible uroprotective effects of curcumin have been addressed in the current study. Haemorrhagic cystitis was induced by challenging male Swiss albino rats with a single dose of cyclophosphamide (150 mg/kg, i.p.)...
  69. ncbi Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice
    Jennifer M A Laird
    Department of Physiology, University of Alcala, Alcala de Henares, E 28871 Madrid, Spain
    J Neurosci 22:8352-6. 2002
    ..absence of additional stimuli, we tried a visceral model of tonic noxious chemical stimulation, cyclophosphamide cystitis. Cyclophosphamide produces cystitis by gradual accumulation of toxic metabolites in the bladder...
  70. ncbi Are quinolone-resistant uropathogenic Escherichia coli less virulent?
    Jordi Vila
    Servei de Microbiologia, Instiutu Clinic Infeccions i Immunologia, Hospital Clinic IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 186:1039-42. 2002
    ..coli strains causing cystitis in women (29 nalidixic acid-susceptible and 29 nalidixic acid-resistant strains)...
  71. ncbi Surveillance study in Europe and Brazil on clinical aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy
    Kurt G Naber
    Technical University of Munich, Munich, Germany
    Eur Urol 54:1164-75. 2008
    Uncomplicated cystitis in females is among the most frequent infections in community.
  72. ncbi Cystitis-induced upregulation of tyrosine kinase (TrkA, TrkB) receptor expression and phosphorylation in rat micturition pathways
    Li Ya Qiao
    Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Comp Neurol 454:200-11. 2002
    ..dorsal root ganglia (DRG) after acute (8 or 48 hours) or chronic (10 days) cyclophosphamide (CYP)-induced cystitis. Increases in the number of TrkA-immunoreactive (IR) cell profiles were detected in the L1 and L6 DRG (four-fold; ..
  73. pmc Relationship between Escherichia coli strains causing acute cystitis in women and the fecal E. coli population of the host
    Eva Moreno
    Microbiology Department, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Clin Microbiol 46:2529-34. 2008
    ..In the present study, 42 women with acute uncomplicated cystitis served as their own controls for an analysis of the causative E. coli strain and the concurrent intestinal E...
  74. ncbi Benefit of Satureja khuzestanica in subchronically rat model of cyclophosphamide-induced hemorrhagic cystitis
    Mohammad Amin Rezvanfar
    Laboratory of Histology, Department of Embryology and Histology, Faculty of Veterinary Medicine, Urmia University, Iran
    Exp Toxicol Pathol 62:323-30. 2010
    Cyclophosphamide (CP) as a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress...
  75. ncbi Ketamine-associated ulcerative cystitis: a new clinical entity
    Rohan Shahani
    Department of Surgery, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Urology 69:810-2. 2007
    ..Increasingly, it is being used as a recreational drug. Recreational ketamine users have anecdotally reported increased lower urinary tract symptoms while using the substance...
  76. pmc European emergence of ciprofloxacin-resistant Escherichia coli clonal groups O25:H4-ST 131 and O15:K52:H1 causing community-acquired uncomplicated cystitis
    Simone Cagnacci
    Sezione di Microbiologia del Di S C A T, University of Genoa, Largo R Benzi, 10, 16132 Genoa, Italy
    J Clin Microbiol 46:2605-12. 2008
    ..In the Mediterranean area, strains belonging to these two clonal groups played a major role in determining the high rate of fluoroquinolone-resistant E. coli strains observed in the community...
  77. pmc Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis
    Lauren Arms
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Renal Physiol 298:F589-600. 2010
    ..01) increases in intercontraction interval, bladder capacity, and void volume. These results suggest a role for CXCL12/CXCR4 signaling in both normal micturition and with bladder hyperreflexia following bladder inflammation...
  78. pmc The use of urine proteomic and metabonomic patterns for the diagnosis of interstitial cystitis and bacterial cystitis
    Que N Van
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Dis Markers 19:169-83. 2003
    ..and contrasted the use of both proteomic and metabonomic patterns in urine for the detection of interstitial cystitis (IC)...
  79. ncbi Preservation of uroplakins by 2-mercaptoethanesulfonate in cyclophosphamide-induced rat cystitis
    Yoon Soo Kyung
    Department of Urology, Dankook University College of Medicine, Ansedong Cheonan Si, Chungcheoung Nam Do, South Korea
    Arch Toxicol 85:51-7. 2011
    Cyclophosphamide (CP) causes extensive cystitis, which is ameliorated with concomitant treatment with mesna...
  80. pmc Expressions of uroplakins in the mouse urinary bladder with cyclophosphamide-induced cystitis
    Seong Hoo Choi
    Department of Urology, Dankook University College of Medicine, Cheonan, Korea
    J Korean Med Sci 24:684-9. 2009
    ..are believed to serve a strong protective barrier against toxic materials, cyclophosphamide (CP) causes extensive cystitis. We investigated the expression of UPs in the urothelium in CP induced mouse cystitis...
  81. pmc Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis
    Gregory G Anderson
    Department of Molecular Microbiology, Washington University, St Louis, Missouri, USA
    Infect Immun 78:963-75. 2010
    ..Together, these data demonstrate the complex but important roles of UPEC polysaccharide encapsulation and sialic acid signaling in multiple stages of UTI pathogenesis...
  82. pmc Bacterial characteristics in relation to clinical source of Escherichia coli isolates from women with acute cystitis or pyelonephritis and uninfected women
    James R Johnson
    Infectious Diseases 111F, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    J Clin Microbiol 43:6064-72. 2005
    Characteristics differentiating Escherichia coli strains that cause cystitis or pyelonephritis from fecal E. coli remain incompletely defined, particularly among adult women in the United States...
  83. ncbi Urinary bladder epithelium antigen induces CD8+ T cell tolerance, activation, and autoimmune response
    Wujiang Liu
    Department of Urology, University of Iowa Roy J and Lucille A Carven College of Medicine, Iowa City, IA 52242, USA
    J Immunol 178:539-46. 2007
    ..Despite this clonal deletion, URO-OVA/OT-I mice spontaneously develop autoimmune cystitis at 10 wk of age...
  84. ncbi Ice water testing reveals hypersensitivity in adult rats that experienced neonatal bladder inflammation: implications for painful bladder syndrome/interstitial cystitis
    Alan Randich
    Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Urol 182:337-42. 2009
    ..to ice water testing, that is infusion of ice-cold saline into the bladder, in patients with painful bladder syndrome/interstitial cystitis have a parallel in a rat model of bladder hypersensitivity produced by neonatal inflammation.
  85. pmc Genetic profiles of fluoroquinolone-resistant Escherichia coli isolates obtained from patients with cystitis: phylogeny, virulence factors, PAIusp subtypes, and mutation patterns
    Akira Takahashi
    Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Clin Microbiol 47:791-5. 2009
    ..coli (FQREC) isolates obtained from patients with cystitis and compared them with those of their fluoroquinolone-susceptible counterparts (FQSEC)...
  86. ncbi Antimicrobial susceptibility of clinical Escherichia coli isolates from uncomplicated cystitis in women over a 1-year period in Spain
    M Gobernado
    Department of Microbiology, University Hospital La Fe, Valencia, Spain
    Rev Esp Quimioter 20:68-76. 2007
    ..Higher resistance rates to ciprofloxacin were associated with being aged 65 years and over. These data need to be considered when recommending empirical therapy for acute cystitis.
  87. pmc OmpA of uropathogenic Escherichia coli promotes postinvasion pathogenesis of cystitis
    Tracy F Nicholson
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 77:5245-51. 2009
    ..directs bladder epithelial binding and invasion by uropathogenic Escherichia coli (UPEC) in the initial stage of cystitis, but the bacterial determinants of postinvasion events in the pathogenesis of cystitis are largely undetermined...
  88. ncbi A phase II study to evaluate WF10 in patients with late hemorrhagic radiation cystitis and proctitis
    Vutisiri Veerasarn
    Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Gynecol Oncol 100:179-84. 2006
    To evaluate efficacy and safety of WF10 (TCDO iv solution) therapy in patients with late hemorrhagic radiation cystitis and proctitis in a long-term follow up.
  89. pmc Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria
    Nils Rodhe
    Centre for Clinical Research, Dalarna, Sweden
    Scand J Prim Health Care 27:74-9. 2009
    Searching for useful diagnostic tools to discriminate between asymptomatic bacteriuria (ASB) and acute cystitis, this study compared urinary levels of cytokines/chemokines and leukocyte esterase in three groups of elderly subjects; those ..
  90. ncbi MR imaging findings of eosinophilic cystitis in an 8-year-old girl
    Ken Tamai
    Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Pediatr Radiol 37:836-9. 2007
    Eosinophilic cystitis is a rare inflammatory condition of the urinary bladder of unknown aetiology and characterized by eosinophilic infiltration of the bladder wall...
  91. ncbi Intravesical glycosaminoglycans in the management of chronic cystitis
    V Iacovelli
    Department of Urology, Tor Vergata University of Rome, Rome, Italy
    Minerva Urol Nefrol 65:249-62. 2013
    ..glycosaminoglycans (GAGs) in urology, with particular emphasis on the therapeutic use in all the chronic forms of cystitis. The so called "bladder layer" is mainly composed by chondroitin sulphate, dermatan sulphate and heparan sulphate...
  92. ncbi Short-course nitrofurantoin for the treatment of acute uncomplicated cystitis in women
    Kalpana Gupta
    Department of Medicine, Yale University and VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Intern Med 167:2207-12. 2007
    There is a paucity of data on the efficacy of nitrofurantoin for the treatment of acute uncomplicated cystitis in regimens shorter than 7 days...
  93. ncbi L6-S1 spinal nerve stimulation reduces micturition frequency in anaesthetized rats with cyclophosphamide-induced cystitis
    Francois A Giuliano
    Pelvipharm Laboratories, CNRS, Gif sur Yvette, AP HP, Raymond Poincare Hospital, Garches, France
    BJU Int 97:386-92. 2006
    ..the rationale for using spinal nerve stimulation (SNS) for treating bladder overactivity associated with cystitis in a rat model of cyclophosphamide-induced cystitis, as several studies suggested that symptoms associated with ..
  94. ncbi Effects of the compounds MV8608 and MV8612 obtained from Mandevilla velutina in the model of hemorrhagic cystitis induced by cyclophosphamide in rats
    André A Santos
    Programa de Pós Graduação em Biologia Celular e Molecular, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 382:399-407. 2010
    Hemorrhagic cystitis (HC) is a common side effect observed in patients under chemotherapy with cyclophosphamide (CYP)...
  95. ncbi Overestimation error and unnecessary antibiotic prescriptions for acute cystitis in adult women
    Warren J McIsaac
    Ray D Wolfe Department of Family Medicine, Mount Sinai Hospital, Toronto, Canada
    Med Decis Making 31:405-11. 2011
    Empiric antibiotic prescribing for suspected acute cystitis may lead to unnecessary prescriptions when urine cultures are negative...
  96. pmc Eosinophilic cystitis associated with eosinophilic enterocolitis: case reports and review of the literature
    M S Kim
    Department of Radiology, Myongji Hospital, Kwandong Univerisity College of Medicine, Korea
    Br J Radiol 83:e122-5. 2010
    We report three cases of eosinophilic cystitis. Contrast-enhanced computed tomography (CT) revealed characteristic bladder wall thickening exceeding 10 mm, with preservation of the mucosal lining and intense, progressive contrast ..
  97. ncbi Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats
    Francisco Yuri Bulcao Macedo
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo, 1315, Rofolfo Teofilo, 60430 270, Fortaleza, CE, Brazil
    J Cancer Res Clin Oncol 134:19-27. 2008
    Hemorrhagic cystitis (HC) is a limiting side effect of chemotherapy with ifosfamide (IFS). In this study, we investigated the participation of cyclooxygenase-2 (COX-2) upon ifosfamide-induced HC.
  98. pmc Virulence genotype and phylogenetic origin in relation to antibiotic resistance profile among Escherichia coli urine sample isolates from Israeli women with acute uncomplicated cystitis
    James R Johnson
    Infectious Diseases, Minneapolis VA Medical Center, One Veterans Dr, Minneapolis, MN 55417, USA
    Antimicrob Agents Chemother 49:26-31. 2005
    ..coli isolates from urine samples of Israeli women with acute uncomplicated cystitis were analyzed by molecular phylotyping and virulence genotyping for comparison with resistance phenotypes...
  99. ncbi Virulence determinants, phylogenetic groups and fluoroquinolone resistance in Escherichia coli isolated from cystitis and pyelonephritis
    S Ferjani
    Laboratoire de Recherche Résistance aux Antimicrobiens, Hôpital Charles Nicolle de Tunis, Boulevard 9 avril, 1006 Tunis, Tunisia
    Pathol Biol (Paris) 60:270-4. 2012
    The aim of this study is to assess the relation between virulence genotype, phylogenetic group and susceptibility to fluoroquinolones and the urinary tract infection type including pyelonephritis and cystitis due to Escherichia coli.
  100. ncbi Recurrent eosinophilic cystitis in a child with chronic granulomatous disease
    Cecilia N Barese
    Division of Immunology, Hospital de Niños Dr Ricardo Gutierrez, Associated Hospital to the Universidad de Buenos Aires, Argentina
    J Pediatr Hematol Oncol 26:209-12. 2004
    Eosinophilic cystitis is an uncommon disease in children, and its association with chronic granulomatous disease (CGD) has been previously reported in only five patients...
  101. pmc Treating acute cystitis with biodegradable micelle-encapsulated quercetin
    Bi Lan Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, People s Republic of China
    Int J Nanomedicine 7:2239-47. 2012
    Intravesical application of an anti-inflammatory drug is an efficient strategy for acute cystitis therapy. Quercetin (QU) is a potent anti-inflammatory agent; however, its poor water solubility restricts its clinical application...

Research Grants73

  1. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..CFS is often comorbid with other disorders that include fibromyalgia, interstitial cystitis (1C), irritable bowel syndrome (IBS), migraines and post-traumatic stress disorder...
  2. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..is a key therapy for treating these malignancies, the dose is limited by the potential for developing radiation cystitis. The acute phase of cystitis includes inflammation and bladder overactivity resulting from disruption of the ..
  3. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..for the treatment of urologic diseases including transitional cell carcinoma of the bladder (TCC), interstitial cystitis (IC), overactive bladder, and detrusor hyperreflexia...
  4. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    ..superinfection and catheterization of the urinary tract on predisposing to recurrences or more severe chronic cystitis. We also test the efficacy of novel mannoside compounds for oral treatment of UTI caused by virulent and multi-..
  5. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..per day of catheterization (50% at 10 days, >90% at 28 days, 100% long term) leading to complications such as cystitis, pyelonephritis, gram-negative bacteremia, prostatitis, epididymitis, urosepsis, septicemia, orchitis, ..
  6. Abnormal Bladder Epithelial Cell Gene Expression in BPS/IC
    SUSAN F KEAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic painful bladder syndrome that affects the lives of approximately one million people in the United States...
  7. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..of nociception and devising rational approaches to treat conditions such as painful bladder syndrome/interstitial cystitis. Delineating gene expression patterns and molecular networks in distinct types of DRG neurons during ontogeny is ..
  8. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..e., cystitis or pyelonephritis, or acute prostatitis...
  9. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2013
    ..it fills is essential in understanding many different bladder disorders, from overactive bladder to interstitial cystitis. Specific aim 1 of our study will examine the repertoire of integrin binding partners in umbrella cells in vivo ..
  10. Reciprocal Control of Motility and Adherence in UTI
    Harry L Mobley; Fiscal Year: 2013
    ..The most common uropathogen, Escherichia coli, can cause acute cystitis or pyelonephritis in the uncomplicated urinary tract...
  11. Optically-Guided Bladder Biopsy Using Polarized Elastic Scattering Spectroscopy
    FREDERICK GEORGE BARGOOT; Fiscal Year: 2010
    ..tissue histology for empirical classification of PESS spectra as indicative of normal urothelium, interstitial cystitis, low-grade bladder carcinoma, or high-grade bladder carcinoma...
  12. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..relevant states, including arthritis, inflammatory bowel disease, chronic bronchitis, migraine and interstitial cystitis. Such a type of inflammation has been known to be initiated by release of inflammatory substances from sensory ..
  13. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Painful bladder syndrome/Interstitial cystitis (PBS/IC) is a chronic painful condition of the urinary bladder in which there are no proven etiologies and no effective treatments that are able to ..
  14. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..g., interstitial cystitis, prostatitis, vulvodynia and fibromyalgia)...
  15. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Painful bladder syndrome/interstitial cystitis (PBS/IC) is an indolent bladder disorder that has continued to be a debilitating disease with few truly effective treatment options...
  16. Directed differentiation of embryonic stem cells for urologic applications
    James A Bassuk; Fiscal Year: 2010
    ..There is a significant need to develop (i) replacement bladders for patients suffering from cancer, interstitial cystitis or neurogenic bladder (spina bifida or multiple sclerosis) and (ii) epithelial tubes for reconstruction of the ..
  17. Mapping serotonin receptors in lower urinary tract innervation
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..bladder, pelvis or urogenital floor is a defining feature of chronic pelvic pain syndromes including Interstitial Cystitis and Chronic Prostatitis...
  18. Urocortin &Musculoskeletal Hyperalgesia
    Alice A Larson; Fiscal Year: 2013
    ..such as fibromyalgia, and various painful abdominal disorders, such as irritable bowel syndrome and interstitial cystitis. These conditions are exacerbated by stress, and, like stress, gastrointestinal disorders are associated with ..
  19. Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action
    Daniel Shoskes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Interstitial cystitis (IC), also referred to as Painful Bladder Syndrome (PBS) is a condition with significant impact on quality of life...
  20. Multi-Disciplinary Evaluation of Chronic Pelvic Pain Syndrome
    GERALD LOUIS ANDRIOLE; Fiscal Year: 2012
    DESCRIPTION, OVERALL (provided by applicant): Our understanding of (UCPPS) such as interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome, (CP/CPPS) is poor...
  21. Trial of mesna to prevent doxorubicin-induced plasma protein oxidation and TNFa r
    Jeffrey A Moscow; Fiscal Year: 2012
    ..mechanism of action, and is frequently given in combination chemotherapy regimens to prevent hemorrhagic cystitis associated with the alkylating agents ifosfamide and high-dose cyclophosphamide, and is commonly coincidentally ..
  22. THE ROLE OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) IN BLADDER PAIN
    HING HUNG HENRY LAI; Fiscal Year: 2013
    ..hypothesis that spinal mGluR5 modulates bladder hyperalgesia in mouse models of bladder pain (cyclophosphamide cystitis, bacterial cystitis)...
  23. Cystitis-Induced Plasticity of Micturitin Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic pain syndrome characterized by pain, pressure or discomfort perceived to be bladder related with at least one urinary symptom...
  24. Effects of Artemin on Nociceptors
    KATHRYN MARIE ALBERS; Fiscal Year: 2013
    ..peptides is commonly elevated in inflammatory diseases such as pancreatitis, psoriasis, rheumatoid arthritis and cystitis. Our findings suggest that the growth factor Artn is produced in inflamed tissue and that its production ..
  25. Delayed Onset of Biofilm Formation and CAUTI with Superhydrophobic Catheters
    Sanjiv Lalwani; Fiscal Year: 2011
    ..when a CAUTI episode becomes symptomatic, the resulting sequelae can range from mild (fever, urethritis and cystitis) to severe (acute pyelonephritis, renal scarring, calculu formation and bacteremia)...
  26. Immune Response to Polyomavirus Infection
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2012
    ..BKV also causes hemorrhagic cystitis which requires clinical intervention in about 5% of hematopoietic stem cell transplantation recipients...
  27. Cross-sensitization in the pelvis and neurogenic bladder
    Anna P Malykhina; Fiscal Year: 2012
    ..Chronic pelvic pain is a common symptom of many urologic and gastrointestinal disorders including interstitial cystitis and irritable bowel syndrome...
  28. Bacterial Survival in the Mammalian Urothelium
    JOSEPH PALERMO; Fiscal Year: 2010
    ..This proposal will use a novel in vitro model of IBCs in conjunction with our well defined murine cystitis model to study bacterial entry in differentiated umbrella cells and identify processes, such as uroplakin ..
  29. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2012
    ..Residual urine in the bladder and urethral catheterization cause cystitis and infection...
  30. Role of Nitric Oxide in Feline Interstitial Cystitis.
    Lori Birder; Fiscal Year: 2009
    Painful bladder syndrome/interstitial cystitis (PBS/IC) is a chronic painful condition of the urinary bladder in which there are no proven etiologies and no effective treatments that are able to ameliorate the symptoms, which include ..
  31. THE OUTER MEMBRANE AS A VIRULENCE PLATFORM
    DAVID ALAN HUNSTAD; Fiscal Year: 2013
    ..We also showed that SurA substrates have an additional role during the post-invasion phase of cystitis, in which UPEC multiply rapidly within bladder epithelial cells to form intracellular bacterial communities (IBCs)..
  32. Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
    JAMES CARTER RICE; Fiscal Year: 2010
    ..coli UTI are asymptomatic. Despite the lack of UTI symptoms, some renal transplant patients with ASB develop cystitis, pyelonephritis or acute kidney injury...
  33. Delineating the importance of intracellular tissue occupation by Uropathogenic E.
    DREW JOEL SCHWARTZ; Fiscal Year: 2013
    ..the induction of a robust immune response predisposes mice to experience persistent bacteriuria and chronic cystitis. This proposal explores the hypothesis that occupation of an intracellular niche during acute infection directly ..
  34. Biomarkers for Acute Pyelonephrititis in Children
    Nader Shaikh; Fiscal Year: 2011
    ..1 In some children with UTI, infection is localized to the bladder (cystitis). In others, bacteria successfully ascend from the bladder to the kidney causing acute pyelonephritis (APN)...
  35. Control of Nociception in the Spinal Cord
    Sukhbir S Mokha; Fiscal Year: 2010
    ..observed below the head region, such as irritable bowel syndrome (IBS), fibromyalgia, interstitial cystitis (1C), vulvodynia, endometriosis and pelvic pain, have a greater prevalence in women or are female-specific...
  36. Comorbid Chronic Pain Conditions - Mechanisms, Diagnosis and Treatments
    Allen W Cowley; Fiscal Year: 2011
    ..chronic fatigue syndrome, chronic headache, endometriosis, fibromyalgia, irritable bowel syndrome, interstitial cystitis, and vulvodynia...
  37. Spinal glia activation in chronic stress-induced visceral hyperalgesia
    Sylvie Bradesi; Fiscal Year: 2013
    ..of the sensory system may be generalized to many other stress-sensitive pain conditions, including interstitial cystitis, non-cardiac chest pain and fibromyalgia...
  38. The Recombinase FimX: Role in type 1 pili regulation and E. coli-induced cystitis
    Patrick C Seed; Fiscal Year: 2010
    Type 1 pili, the preeminent virulence determinant in Escherichia coli-associated cystitis, promote binding to the bladder surface and facilitate the colonization and invasion of the epithelium. In their intracellular residence, E...
  39. Developing a Novel Peptide Therapeutic for Interstitial Cystitis/Painful Bladder
    Graham P Allaway; Fiscal Year: 2010
    ..the in vivo efficacy and mechanism of action of a novel, first-in-class drug candidate for treating interstitial cystitis/painful bladder syndrome (IC/PBS)...
  40. Children's Hospital Boston George O'Brien Urology Research Center
    Rosalyn M Adam; Fiscal Year: 2012
    ..of recognizing and treating pediatric OAB as a precursor to adult OAB and painful bladder syndrome/interstitial cystitis (PBS/IC)...
  41. Bladder drug delivery using intravesical liposomes to treat overactive bladder
    JONATHAN H KAUFMAN; Fiscal Year: 2012
    ..SBIR) grants to develop intravesical liposome nanoparticles to treat overactive bladder (OAB), interstitial cystitis/painful bladder syndrome (IC/PBS)...
  42. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..bladder is often the site of subacute or chronic inflammation, in the absence of infection, as in interstitial cystitis (IC), a painful bladder disorder occurring mostly in women...
  43. Investigation and treatment of central nervous system dysfunction in chronic pelv
    Felipe Fregni; Fiscal Year: 2010
    ..tDCS in reducing pain in a cohort of chronic pelvic pain patients (with painful bladder syndrome or interstitial cystitis) via a phase-II, double-blinded, sham- controlled, parallel, randomized clinical trial and also assess the safety ..
  44. Molecular and spatial mapping of bladder nociceptors during development and matur
    Adam Wallace; Fiscal Year: 2013
    ..This project is relevant to genitourinary pain, such as interstitial cystitis/painful bladder syndrome...
  45. Validation in Transgenic Animal Models of Clinical Correlates of IC/PBS
    Yi Luo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic inflammatory condition of the urinary bladder characterized by symptoms of chronic pelvic pain and urinary frequency and urgency in ..
  46. Endogenous Cannabinoids and NGF Signaling in Pain Associated with Cystitis
    DALE EDMOND BJORLING; Fiscal Year: 2013
    ..The long range goal is to provide improved options for treatment or prevention of bladder pain that have fewer undesirable side effects than those associate with currently-available therapeutic options. ..
  47. Endocytic and Exocytic Traffic in Bladder uroepithelium
    Gerard L Apodaca; Fiscal Year: 2013
    ..expression of surface receptors and other proteins that is associated with bladder diseases such as interstitial cystitis. The overall hypothesis to be tested In this proposal is that umbrella cells respond to their mechanical ..
  48. Generating molecular markers that selectively label urothelial sub-populations
    CATHY LEE MENDELSOHN; Fiscal Year: 2013
    ..The urothelium can be rendered dysfunctional by damage, or disease, including interstitial cystitis, inflammation and UTI, but at present there is no way to repair/regenerate this tissue...
  49. Adenosine Receptor Function in Bladder Uroepithelium
    Gerard L Apodaca; Fiscal Year: 2012
    ..and will ultimately allow us to understand how perturbations in uroepithelial-associated receptor expression and signal output can contribute to bladder diseases such as interstitial cystitis and detrusor overactivity.
  50. ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTION
    DAVID ALAN HUNSTAD; Fiscal Year: 2013
    ..of these antimicrobial-bearing, adhesin-coupled NPs, both in vitro and in murine models of acute and chronic cystitis caused by uropathogenic E. coli...
  51. Novel Oral Therapy For the Mucopolysaccharidoses
    CALOGERA MARIA SIMONARO; Fiscal Year: 2013
    ..It is currently approved for use in patients with interstitial cystitis, and its safety has been demonstrated through clinical testing...
  52. Bladder Nociception: function/central projection of Sympathetic Afferent Pathway
    William C DeGroat; Fiscal Year: 2013
    DESCRIPTION: Painful bladder syndrome/interstitial cystitis (PBS/IC) is a disease with unknown etiology, which presents clinically as urinary urgency, frequency, and bladder associated pain...
  53. Cellular Physiology of Sensory Ion Channels
    David Julius; Fiscal Year: 2013
    ..acute pain and chronic inflammatory pain syndromes, such as arthritis, inflammatory bowel disease, hemorrhagic cystitis, asthma and other constrictive airway disorders...
  54. Genetic Studies of Interstitial Cystitis
    Louis M Kunkel; Fiscal Year: 2011
    Painful bladder syndrome/interstitial cystitis (PBS/IC) is a chronic, debilitating clinical syndrome presenting as severe pelvic pain with extreme urinary urgency and frequency in the absence of any known cause...
  55. Effects of Inflammation in a Mouse Model of Interstital Cystitis
    Jennifer J DeBerry; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Interstitial cystitis (IC) is an inflammatory chronic bladder disorder characterized by suprapubic pain and bladder dysfunction...
  56. INDUCTION AND MODULATION OF HOST RESPONSES BY UPEC
    Anthony J Schaeffer; Fiscal Year: 2013
    ..coli (UPEC) that elicit an inflammatory response in the bladder during acute cystitis. Identifying novel therapeutic targets against UPEC is critical because of both the high incidence of UTIs and ..
  57. MIF: a pro-inflammatory cytokine as a novel target to reduce bladder inflammation
    Pedro L Vera; Fiscal Year: 2013
    ..2) Identify the contribution of urothelial MIF receptors (CD74;CXCR4) to MIF signaling and cystitis: MIF receptor blockade will be used to examine changes in MIF-mediated signaling during a well-established model ..
  58. Brain Bladder Interactions in IC/PBS
    LARISSA RODRIGUEZ; Fiscal Year: 2012
    DESCRIPTION, OVERALL (provided by applicant): Interstitial cystitis/painful bladder syndrome (IC/PBS) is a common chronic bladder syndrome characterized by bladder pain and discomfort (urgency) and increased frequency of urination...
  59. E. coli virulence gene expression during clinical UTIs in women
    Harry L Mobley; Fiscal Year: 2013
    ..1) Determine the adhesins expressed during UTI in humans;2) determine the iron acquisition systems required for cystitis and those required for acute pyelonephritis;and 3) Determine the toxins expressed during human UTI that predict ..
  60. Decision support with MRI for targeting, evaluating laser ablation for prostate c
    Anant Madabhushi; Fiscal Year: 2013
    ..the bladder can lead to complications including chronic rectal bleeding, diarrhea, and urinary symptoms such as cystitis. Laser induced interstitial thermal therapy (LITT) is a novel form of controlled, targeted thermal ablation that ..
  61. PROFILING VULVODYNIA BASED ON NEUROBIOLOGICAL AND BEHAVIORAL ENDOPHENOTYPES
    Andrea J Rapkin; Fiscal Year: 2013
    ..female healthy controls (HC), 200 patients with irritable bowel syndrome (IBS) and 100 patients with interstitial cystitis/painful bladder syndrome which are available from a large brain scan repository at UCLA...
  62. Treatment of Bladder Pain by Novel Glycosaminoglycan Derivatives
    Siam Oottamasathien; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT Interstitial cystitis (IC)/painful bladder syndrome (PBS) is a debilitating chronic urologic condition. Over 3 million women above the age of 18 in the U.S...
  63. Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP)
    Karl J Kreder; Fiscal Year: 2012
    ..expenditure the pathophysiology of the Urologic Chronic Pelvic Pain Syndrome (UCPPS) known as Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) remains elusive...
  64. UROTHELIAL CELL ACTIVATION IN INTERSTITIAL CYSTITIS
    Monica Liebert; Fiscal Year: 1993
    Interstitial cystitis is a poorly understood inflammatory condition occurring in the urinary bladder...
  65. Interstitial Cystitis Clinical Research Network
    Christopher Payne; Fiscal Year: 2007
    ..National Clinical Centers in a cooperative effort to develop clinical trials for the study of interstitial cystitis (IC)...
  66. IMMUNE MEDIATED BLADDER INFLAMMATION
    Timothy Ratliff; Fiscal Year: 2002
    ..include bacterial infection, response to therapeutic antigens such as BCG (used in treatment of interstitial cystitis and bladder cancer), and although controversial, some have suggested a role for immunity in interstitial cystitis...
  67. Proteomic Characterization of IC Bladder
    Pradeep Tyagi; Fiscal Year: 2006
    Interstitial cystitis (IC) is a painful bladder syndrome of unknown etiology, characterized by chronic pelvic pain, urinary frequency and urgency...
  68. Mouse Models for Interstitial Cystitis
    Edward Schwarz; Fiscal Year: 2004
    Interstitial Cystitis (IC) is a chronic irritable voiding syndrome of unknown etiology...
  69. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..that the applicants confirm their interest and ability to take part in clinical treatment trials in Intersitial Cystitis (IC). The Queen's University Intersitial Cystitis Research Group is established under the directorship of Dr...
  70. REGENERATION OF FUNCTIONAL SMOOTH MUSCLE TISSUE
    Emil Tanagho; Fiscal Year: 2004
    ..of regeneration of acellular matrix bladder when grafted to the host bladder (normal, diabetic and interstitial cystitis) after partial cystectomy...
  71. DCC--INTERSTITIAL CYSTITIS CLINICAL TRIALS GROUP
    J Landis; Fiscal Year: 2003
    ..the University of Pennsylvania Medical Center to serve as the Data Coordinating Center (DCC) for the Interstitial Cystitis Clinical Trials Group (ICCTG)...
  72. INTERSTITIAL CYSTITIS PHASE II TRIALS
    Daniel Culkin; Fiscal Year: 2003
    DESCRIPTION: (Abstract of the application) Interstitial cystitis is a disease, which may affect over a million residents of the United States...
  73. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    Interstitial cystitis (IC) is a syndrome that afflicts up to 1 million Americans with grave morbidity due to severe pelvic pain and voiding dysfunction...