respiratory syncytial virus infections

Summary

Summary: Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.

Top Publications

  1. ncbi Mortality associated with influenza and respiratory syncytial virus in the United States
    William W Thompson
    Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 289:179-86. 2003
  2. ncbi Respiratory syncytial virus infection in elderly and high-risk adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    N Engl J Med 352:1749-59. 2005
  3. pmc Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
    Harish Nair
    Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
    Lancet 375:1545-55. 2010
  4. ncbi The burden of respiratory syncytial virus infection in young children
    Caroline Breese Hall
    Department of Pediatrics, The University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    N Engl J Med 360:588-98. 2009
  5. pmc Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years
    Peter L Collins
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virus Res 162:80-99. 2011
  6. pmc Animal models of human respiratory syncytial virus disease
    Reinout A Bem
    Pediatric Intensive Care Unit, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 301:L148-56. 2011
  7. ncbi Respiratory syncytial virus and recurrent wheeze in healthy preterm infants
    Maarten O Blanken
    Division of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, The Netherlands
    N Engl J Med 368:1791-9. 2013
  8. pmc IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease
    Sumanta Mukherjee
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Pathol 179:248-58. 2011
  9. pmc Viral etiology of severe pneumonia among Kenyan infants and children
    James A Berkley
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    JAMA 303:2051-7. 2010
  10. pmc Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection
    Ross B Fulton
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:2382-92. 2010

Research Grants

  1. Signaling in Airway Inflammation
    Roberto P Garofalo; Fiscal Year: 2013
  2. Sixth International Respiratory Syncytial Virus Symposium
    ANN FALSEY; Fiscal Year: 2007
  3. IMMUNOGENETICS AND THE PATHOGENESIS OF RSV INFECTION
    John DeVincenzo; Fiscal Year: 2004
  4. Mucosal RSV vaccine using CpG oligodeoxynucleotides
    Gregory Prince; Fiscal Year: 2003
  5. Pathogenesis of RSV disease in the Elderly
    Edward Walsh; Fiscal Year: 2008
  6. IMPROVEMENT OF THE COTTON RAT MODEL OF HUMAN DISEASES
    Gregory Prince; Fiscal Year: 2002
  7. Novel Model to Predict Safety and Efficacy of Microbicides
    Gregory Prince; Fiscal Year: 2007
  8. PRIMARY HHV6 INFECTION--CLINICAL & VIRAL CHARACTERISTICS
    Caroline Hall; Fiscal Year: 2001
  9. Congenital HHV6 Infection: Characteristics and Outcome
    Caroline Hall; Fiscal Year: 2007
  10. CONTROL OF EPIDEMIC INFLUENZA
    PEDRO PIEDRA; Fiscal Year: 2007

Detail Information

Publications307 found, 100 shown here

  1. ncbi Mortality associated with influenza and respiratory syncytial virus in the United States
    William W Thompson
    Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 289:179-86. 2003
    ..Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have not accounted for RSV circulation...
  2. ncbi Respiratory syncytial virus infection in elderly and high-risk adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    N Engl J Med 352:1749-59. 2005
    ..Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help in assessing the need for vaccine development...
  3. pmc Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
    Harish Nair
    Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
    Lancet 375:1545-55. 2010
    ..We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005...
  4. ncbi The burden of respiratory syncytial virus infection in young children
    Caroline Breese Hall
    Department of Pediatrics, The University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    N Engl J Med 360:588-98. 2009
    ..The primary role of respiratory syncytial virus (RSV) in causing infant hospitalizations is well recognized, but the total burden of RSV infection among young children remains poorly defined...
  5. pmc Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years
    Peter L Collins
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virus Res 162:80-99. 2011
    ..Vaccines and new antiviral drugs are in pre-clinical and clinical development, but controlling RSV remains a formidable challenge...
  6. pmc Animal models of human respiratory syncytial virus disease
    Reinout A Bem
    Pediatric Intensive Care Unit, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 301:L148-56. 2011
    ..The purpose of this review is to summarize the strengths and limitations of each of these animal models. Our intent is to provide a resource for investigators and an impetus for future research...
  7. ncbi Respiratory syncytial virus and recurrent wheeze in healthy preterm infants
    Maarten O Blanken
    Division of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, The Netherlands
    N Engl J Med 368:1791-9. 2013
    ..The monoclonal antibody palivizumab has shown efficacy in preventing severe RSV infection in high-risk infants...
  8. pmc IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease
    Sumanta Mukherjee
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Pathol 179:248-58. 2011
    ..Taken together, our data demonstrate that IL-17 plays a pathogenic role during RSV infections...
  9. pmc Viral etiology of severe pneumonia among Kenyan infants and children
    James A Berkley
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    JAMA 303:2051-7. 2010
    ..Pneumonia is the leading cause of childhood death in sub-Saharan Africa. Comparative estimates of the contribution of causative pathogens to the burden of disease are essential for targeted vaccine development...
  10. pmc Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection
    Ross B Fulton
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:2382-92. 2010
    ....
  11. ncbi Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States, 1997-2006
    Lauren J Stockman
    Centers for Disease Control and Prevention, Division of Viral Diseases, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 31:5-9. 2012
    ..RSV-associated hospitalization increased among children in the United States during 1980 through 1996. In this study, we updated national estimates of RSV hospitalization rates among US children through 2006...
  12. pmc The natural history of respiratory syncytial virus in a birth cohort: the influence of age and previous infection on reinfection and disease
    E O Ohuma
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Kilifi, Kenya
    Am J Epidemiol 176:794-802. 2012
    ..A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005...
  13. pmc The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus
    S Yusuf
    Division of Infectious Diseases, Department of Pediatrics, State University of New York at Buffalo and Women and Children s Hospital, Buffalo, NY, USA
    Epidemiol Infect 135:1077-90. 2007
    ..UVB radiation may inactivate virus in the environment, or influence susceptibility to RSV by altering host resistance...
  14. pmc Incidence and severity of respiratory syncytial virus pneumonia in rural Kenyan children identified through hospital surveillance
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Clin Infect Dis 49:1341-9. 2009
    ..Although necessary for developing a rationale for vaccination, the burden of severe respiratory syncytial virus (RSV) disease in children in resource-poor settings remains poorly defined...
  15. pmc Viral and host factors in human respiratory syncytial virus pathogenesis
    Peter L Collins
    NIAID, NIH, 50 South Drive, MSC 8007, Bethesda, MD 20892, USA
    J Virol 82:2040-55. 2008
  16. ncbi Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13
    Nele Sigurs
    Department of Pediatrics, Borås Central Hospital, Boras, Sweden
    Am J Respir Crit Care Med 171:137-41. 2005
    ..RSV bronchiolitis in infancy severe enough to cause hospitalization is a risk factor for allergic asthma in early adolescence...
  17. ncbi Are meteorological parameters associated with acute respiratory tract infections?
    Jean Baptist du Prel
    Kinderklinik, Paediatrische Infektiologie and Zentrum Praeventive Paediatrie, Universitaetsmedizin, Johannes Gutenberg Universitaet, Mainz, Germany
    Clin Infect Dis 49:861-8. 2009
    ..Aiming at better predictions of the seasonal activity of ARI pathogens, we investigated the influence of climate on hospitalizations for ARIs...
  18. pmc Genetic variability of human respiratory syncytial virus A strains circulating in Ontario: a novel genotype with a 72 nucleotide G gene duplication
    Alireza Eshaghi
    Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada
    PLoS ONE 7:e32807. 2012
    ..Further work is needed to document and further understand the emergence, virulence, pathogenicity and transmissibility of this novel RSV-A genotype with a72 nucleotide G gene duplication...
  19. ncbi Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children
    Marika K Iwane
    National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Pediatrics 113:1758-64. 2004
    ....
  20. ncbi Bronchiolitis-associated hospitalizations among US children, 1980-1996
    D K Shay
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 282:1440-6. 1999
    ..Few national estimates exist of the hospitalizations attributable to RSV, and recent advances in prophylaxis warrant an update of these estimates...
  21. pmc Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers
    Kurt A Swanson
    Novartis Vaccines and Diagnostics, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:9619-24. 2011
    ..This unanticipated structural feature explains the engineered RSV F antigen's efficiency as an immunogen. This work illustrates how structural-based antigen design can guide the rational optimization of candidate vaccine antigens...
  22. ncbi Down syndrome and hospitalizations due to respiratory syncytial virus: a population-based study
    Philip Zachariah
    Department of Pediatrics, University of Colorado, Denver, CO, USA
    J Pediatr 160:827-31.e1. 2012
    ..To assess the risk estimates for respiratory syncytial virus (RSV) hospitalization in children with Down syndrome (DS) and the clinical features and severity of RSV lower respiratory tract infection (LRTI) in hospitalized children...
  23. pmc Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection
    Fengqi Li
    Department of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
    J Virol 86:2251-8. 2012
    ..These data show that NK cells are involved in exacerbating the lung immune injury at the early stage of RSV infection via IFN-γ secretion...
  24. pmc A study of the genetic variability of human respiratory syncytial virus (HRSV) in Cambodia reveals the existence of a new HRSV group B genotype
    Alicia Arnott
    Institut Pasteur in Cambodia, Réseau International des Instituts Pasteur, 5 Monivong blvd, P O Box 983, Phnom Penh, Cambodia
    J Clin Microbiol 49:3504-13. 2011
    ..The majority of HRSV group B strains belonged to the recently described BA genotype, with the exception of 10 strains classified as belonging to a novel HRSV group B genotype, SAB4, first reported here...
  25. pmc Biological challenges and technological opportunities for respiratory syncytial virus vaccine development
    Barney S Graham
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3017, USA
    Immunol Rev 239:149-66. 2011
    ..These new technologies may allow development of vaccines that can protect against RSV-mediated disease in infants and establish a new immunological paradigm in the host to achieve more durable protection against reinfection...
  26. pmc The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand
    Alicia M Fry
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 5:e15098. 2010
    ..We describe the epidemiology of hospitalized RSV infections for all age groups from population-based surveillance in two rural provinces in Thailand...
  27. pmc Identification of multiple protective epitopes (protectopes) in the central conserved domain of a prototype human respiratory syncytial virus G protein
    H Plotnicky-Gilquin
    Centre d Immunologie Pierre Fabre, 74164 Saint Julien en Genevois cedex, France
    J Virol 73:5637-45. 1999
    ..Should these murine protectopes also be implicated in human LRT protection, their clustering around the highly conserved cysteine noose region will have important implications for the development of RSV vaccines...
  28. pmc Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent
    K A Shirey
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, Baltimore, MD, USA
    Mucosal Immunol 3:291-300. 2010
    ..RSV-infected cotton rats treated with a cyclooxygenase-2 inhibitor increased expression of lung AA-M phi. These data suggest new treatment strategies for RSV that promote AA-M phi differentiation...
  29. ncbi Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants
    Ruth A Karron
    Center for Immunization Research, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Infect Dis 191:1093-104. 2005
    ..Recombination technology can be used to create live attenuated respiratory syncytial virus (RSV) vaccines that contain combinations of known attenuating mutations...
  30. pmc Natural history of human respiratory syncytial virus inferred from phylogenetic analysis of the attachment (G) glycoprotein with a 60-nucleotide duplication
    Alfonsina Trento
    Unidad de Biología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    J Virol 80:975-84. 2006
    ..We have taken advantage of this situation to reexamine the molecular epidemiology of HRSV and to explore the natural history of this important human pathogen...
  31. pmc Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development
    Philippa K Pribul
    Department of Respiratory Medicine, Paddington Campus of Imperial College, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 82:4441-8. 2008
    ..Therefore, lung macrophages play a central role in the early responses to viral infection but have remarkably little effect on the adaptive response occurring at the time of peak disease severity...
  32. pmc Viral acute lower respiratory infections impair CD8+ T cells through PD-1
    John J Erickson
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Clin Invest 122:2967-82. 2012
    ..Therefore, the PD-1/PD-L1 pathway may represent a therapeutic target in the treatment of respiratory viruses...
  33. ncbi Epidemiology of respiratory syncytial virus infection in northern Taiwan, 2001-2005 -- seasonality, clinical characteristics, and disease burden
    Jian Te Lee
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 40:293-301. 2007
    ..However, there is limited epidemiological data about RSV infection in Taiwan. This study aimed to investigate the clinical, epidemiological, virological, and economical aspects of RSV infections in Taiwan...
  34. pmc Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma
    Nandini Krishnamoorthy
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Med 18:1525-30. 2012
    ..Our findings highlight a mechanism by which viral infection targets a host-protective mechanism in early life and increases susceptibility to allergic disease...
  35. pmc A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
    John DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN 38103, USA
    Proc Natl Acad Sci U S A 107:8800-5. 2010
    ....
  36. pmc Genetic variability in the G protein gene of group A and B respiratory syncytial viruses from India
    Shama Parveen
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India
    J Clin Microbiol 44:3055-64. 2006
    ..78) than within the genotypes (dN/dS, 0.69). These are among the first molecular analyses of RSV strains from the second most populous country in the world and will be useful for comparisons to candidate vaccine strains...
  37. pmc Respiratory viruses and eosinophils: exploring the connections
    Helene F Rosenberg
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Antiviral Res 83:1-9. 2009
    ..Lastly, we consider the data that focus on the role of eosinophils in promoting virus clearance and antiviral host defense, and conclude with a recent study that explores the role of eosinophils themselves as targets of virus infection...
  38. pmc Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection
    Kayla A Weiss
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 187:3145-54. 2011
    ..These results demonstrate that IL-10 plays a critical role in modulating the adaptive immune response to RSV by limiting T-cell-mediated pulmonary inflammation and injury...
  39. ncbi Bovine respiratory disease research (1983-2009)
    Robert W Fulton
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Anim Health Res Rev 10:131-9. 2009
    ..Attempts have been made to document how prevention of BRD by proper vaccination and management prior to exposure to infectious agents can minimize disease and serve as economic incentives for certified health programs...
  40. pmc Respiratory syncytial virus vaccine development
    Julia L Hurwitz
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Expert Rev Vaccines 10:1415-33. 2011
    ..The development of a successful RSV vaccine may ultimately stem from attention to historical lessons, in concert with an integral partnering of immunology and virology research fields...
  41. pmc Molecular epidemiology and evolution of human respiratory syncytial virus and human metapneumovirus
    Eleanor R Gaunt
    Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e17427. 2011
    ..For both viruses, different sites were identified as positively selected between genetic groups...
  42. ncbi Hospitalized children with respiratory syncytial virus infection and neuromuscular impairment face an increased risk of a complicated course
    Anja Wilkesmann
    Children s Hospital Medical Center, University of Bonn, Germany
    Pediatr Infect Dis J 26:485-91. 2007
    ....
  43. pmc Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]
    Kirsten M Spann
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8007, USA
    J Virol 78:4363-9. 2004
    ..F. Valarcher, J. Furze, S. Wyld, R. Cook, K. K. Conzelmann, and G. Taylor, J. Virol. 77:8426-8439, 2003). This pattern of inhibition by HRSV NS1 and NS2 also extended to the newly described antiviral cytokines IFN-lambda 1, -2 and -3...
  44. pmc New genotypes within respiratory syncytial virus group B genotype BA in Niigata, Japan
    Isolde C Dapat
    Division of Public Health, Department of Infectious Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, Niigata Prefecture 951 8510, Japan
    J Clin Microbiol 48:3423-7. 2010
    ..These new genotypes were not associated with large outbreaks in the community...
  45. ncbi Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX, USA
    Vaccine 21:3479-82. 2003
    ..To determine if respiratory syncytial virus (RSV) specific, serum antibody titers correlate with protection against RSV associated-hospitalization at all ages...
  46. pmc Human respiratory syncytial virus in children with acute respiratory tract infections in China
    Rong Fang Zhang
    School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China
    J Clin Microbiol 48:4193-9. 2010
    ..Coinfection with other viruses does not affect disease severity. HRSV genotypes were not associated with different epidemiological characterizations or disease severity...
  47. ncbi Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    E A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 1:398-401. 2000
    ..RSV persisted longer in the lungs of infected TLR4-deficient mice compared to normal mice. Thus, a common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens...
  48. pmc Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007
    Janine Reiche
    FG12 Virale Infektionen, NRZ Influenza, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Clin Microbiol 47:1800-10. 2009
    ..This study provides for the first time data on the circulation pattern of RSV group A genotypes and their molecular characterization in Germany during nine consecutive epidemic seasons...
  49. pmc Ten years of global evolution of the human respiratory syncytial virus BA genotype with a 60-nucleotide duplication in the G protein gene
    Alfonsina Trento
    Unidad de Biología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Virol 84:7500-12. 2010
    ..After that date and coinciding with a bottleneck effect on the population size, a relatively new BA lineage (BA-IV) replaced all other group B viruses, suggesting further adaptation of the BA genotype to its natural host...
  50. pmc Pharmacologic advances in the treatment and prevention of respiratory syncytial virus
    Kerry M Empey
    Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 50:1258-67. 2010
    ....
  51. ncbi Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis
    Malcolm G Semple
    Department of Child Health, University of Liverpool, Liverpool, United Kingdom
    J Infect Dis 191:382-6. 2005
    ..99 [95% confidence interval, 5.0-24.12]; P<.001, by Fisher exact test). Dual infection by hMPV and hRSV is associated with severe bronchiolitis...
  52. ncbi Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    J Infect Dis 195:1126-36. 2007
    ..It is widely believed that both viral replication and inappropriately enhanced immune responses contribute to disease severity. In infants, RSV LRTI is known to be more severe than influenza virus LRTI...
  53. ncbi Respiratory syncytial virus epidemics: the ups and downs of a seasonal virus
    Lone Graff Stensballe
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Copenhagen, Denmark
    Pediatr Infect Dis J 22:S21-32. 2003
    ..Generally RSV mortality is low, with a median value of zero. However, RSV mortality in developing countries is significantly higher than RSV mortality in developed countries...
  54. pmc Emerging genotypes of human respiratory syncytial virus subgroup A among patients in Japan
    Yugo Shobugawa
    Department of Infectious Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata City, Japan
    J Clin Microbiol 47:2475-82. 2009
    ..Continuing studies to follow up the genetic changes and to clarify the mechanism of reinfection in HRSV are important steps to understand HRSV infections...
  55. ncbi Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease
    Guy Tal
    Pediatric Pulmonary Unit, Edith Wolfson Medical Center, Tel Aviv University, Holon, Israel
    J Infect Dis 189:2057-63. 2004
    ..Thus, it is likely that factors such as genetic heterogeneity contribute to disease severity. Toll-like receptor 4 (TLR4) and CD14 are part of a receptor complex involved in the innate immune response to RSV...
  56. ncbi Molecular epidemiology of respiratory syncytial virus
    P A Cane
    Division of Immunity and Infection, University of Birmingham Medical School, Birmingham B15 2TT, UK
    Rev Med Virol 11:103-16. 2001
    ..The evolution of the virus is discussed, with particular reference to the antigenic and genetic variability of the attachment glycoprotein...
  57. pmc Genetic variability of respiratory syncytial viruses (RSV) prevalent in Southwestern China from 2006 to 2009: emergence of subgroup B and A RSV as dominant strains
    Zhi Yong Zhang
    Division of Immunology, Children s Hospital, Chongqing Medical University, Chongqing 400014, China
    J Clin Microbiol 48:1201-7. 2010
    ..These data suggest that group A RSV likely predominated in southwestern China and that a new genotype of subgroup B with a 60-nucleotide insertion, named BA-like virus, became the dominant genotype in the 2008-2009 epidemic season...
  58. pmc Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness
    Mindy S Lo
    Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 79:9315-9. 2005
    ..RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion...
  59. pmc Respiratory syncytial virus infection in adults
    A R Falsey
    Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    Clin Microbiol Rev 13:371-84. 2000
    ..An effective RSV vaccine has not yet been developed, and thus prevention of RSV infection is limited to standard infection control practices such as hand washing and the use of gowns and gloves...
  60. ncbi Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection
    Robert C Welliver
    Department of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Division of Infectious Diseases, Children s Hospital of Buffalo, New York 14222, USA
    J Pediatr 143:S112-7. 2003
    ..Pulmonary hypertension and cyanosis are associated with worse outcomes in infants with congenital heart disease, and prolonged viral replication accounts for more severe illness in immunocompromised individuals...
  61. pmc Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis
    Carla G García
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Texas, USA
    Pediatrics 126:e1453-60. 2010
    ..The trends in hospitalization rates and risk factors for severe bronchiolitis have not been recently described, especially after the routine implementation of prophylaxis for respiratory syncytial virus (RSV) infections...
  62. ncbi Respiratory viral infections in patients with chronic, obstructive pulmonary disease
    J David Beckham
    Department of Medicine, Baylor College of Medicine and Ben Taub General Hospital, One Baylor Plaza, Houston, TX 77030, USA
    J Infect 50:322-30. 2005
    ..The purpose of the present study was to apply reverse transcription-PCR (RT-PCR) assays to clinical specimens collected from patients with acute respiratory illness and chronic obstructive pulmonary disease (COPD)...
  63. pmc Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins
    Lori W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Room S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 85:366-77. 2011
    ..These results suggest that these VLPs are effective RSV vaccines in mice, in contrast to other nonreplicating RSV vaccine candidates...
  64. ncbi Real-time PCR to improve the diagnosis of respiratory syncytial virus infection
    R Mentel
    Friedrich Loeffler Institute of Medical Microbiology, University Hospital, Ernst Moritz Arndt University Greifswald, Germany
    J Med Microbiol 52:893-6. 2003
    ..7 %) by nested RT-PCR. The assay was specific for RSV. The procedure offers a rapid and sensitive alternative to conventional RT-PCR. Closed-tube detection eliminates the risk of contamination...
  65. pmc Genetic variability among complete human respiratory syncytial virus subgroup A genomes: bridging molecular evolutionary dynamics and epidemiology
    Lydia Tan
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e51439. 2012
    ....
  66. pmc TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection
    Jesus Segovia
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e29695. 2012
    ....
  67. ncbi Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells
    S M Varga
    Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Immunity 15:637-46. 2001
    ....
  68. ncbi High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections
    N Lee
    Department of Medicine and Therapeutics
    Clin Infect Dis 57:1069-77. 2013
    ..Better understanding of complications and outcomes of adults hospitalized with respiratory syncytial virus (RSV) infection is necessary...
  69. ncbi Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins
    A Uttenthal
    Danish Veterinary Laboratory, Bulowsvej 27, DK 1790, Copenhagen V, Denmark
    Vet Microbiol 76:329-41. 2000
    ..Test samples from two herds out of 50 were free from all isotypes to BRSV...
  70. pmc Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus
    Teresa R Johnson
    Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, United States of America
    PLoS ONE 6:e16458. 2011
    ..Defining the influence of RSV on the function of selected DC subsets may improve the likelihood of achieving protective vaccine-induced immunity...
  71. ncbi Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease
    Timothy F Feltes
    Ohio State University and The Children s Hospital, 700 Children s Drive, ED622, Columbus, OH 43205, USA
    J Pediatr 143:532-40. 2003
    ..To evaluate the safety, tolerance, and efficacy of palivizumab in children with hemodynamically significant congenital heart disease (CHD)...
  72. ncbi Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivo
    M N Teng
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, 7 Center Dr. MSC 0720, Bethesda, Maryland 20892-0720, USA
    Virology 289:283-96. 2001
    ..Thus, the putative heparin-binding domain is not the sole determinant of heparin sensitivity and is not a critical functional domain...
  73. ncbi Comparison of human metapneumovirus, respiratory syncytial virus and influenza A virus lower respiratory tract infections in hospitalized young children
    Dana G Wolf
    Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, Jerusalem, Israel
    Pediatr Infect Dis J 25:320-4. 2006
    ....
  74. ncbi Bronchiolitis
    Rosalind L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Lancet 368:312-22. 2006
    ..Careful mapping of the inflammatory pathways in the pathogenesis of bronchiolitis should lead to development of new therapies to alleviate symptoms...
  75. pmc Respiratory syncytial virus infection: immune response, immunopathogenesis, and treatment
    J B Domachowske
    State University of New York Health Science Center at Syracuse, Syracuse, New York 13210
    Clin Microbiol Rev 12:298-309. 1999
    ..Although the treatment of RSV bronchiolitis is primarily supportive, the role of ribavirin is briefly discussed. Novel approaches to the development of new antiviral drugs with promising anti-RSV activity in vitro are also described...
  76. ncbi CARESS: the Canadian registry of palivizumab
    Ian Mitchell
    Department of Pediatrics, University of Calgary, Alberta Children s Hospital, Calgary, AB, Canada
    Pediatr Infect Dis J 30:651-5. 2011
    ..Palivizumab is indicated for respiratory syncytial virus (RSV) prophylaxis in high-risk children. However, relatively little is known about the current use, compliance, and outcomes associated with this medication...
  77. ncbi Epidemiology and prevention of respiratory syncytial virus infections among infants and young children
    Gayle Fischer Langley
    Division of Viral Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Pediatr Infect Dis J 30:510-7. 2011
    ..This article reviews the epidemiology of RSV infections in infants and young children, including risk factors for severe disease, so as to inform decisions about prevention efforts...
  78. pmc The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung
    John S Tregoning
    Department of Respiratory Medicine, The Centre for Respiratory Infections Research, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9381. 2010
    ..The chemokine CCL3 (MIP1alpha) is produced following RSV infection and is broadly chemotactic for both T cells and natural killer (NK) cells. We therefore investigated its role in RSV disease...
  79. pmc Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection
    J Loebbermann
    Department of Medicine, Centre for Respiratory Infection MRC and Asthma UK Centre, National Heart and Lung Institute, Imperial College, London, UK
    Mucosal Immunol 5:161-72. 2012
    ....
  80. pmc Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice
    Kate L Stokes
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    J Virol 85:5782-93. 2011
    ..We found that RSV clinical isolates induce variable pathogenesis in mice, and we established a mouse model of clinical isolate strain-dependent RSV pathogenesis that recapitulates key features of RSV disease...
  81. ncbi Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life
    Nele Sigurs
    Department of Paediatrics, Borås Central Hospital, Borås S 50182, Sweden
    Thorax 65:1045-52. 2010
    ..A study was undertaken to examine whether these features persist into early adulthood, to report longitudinal wheeze and allergy patterns, and to see how large and small airway function relates to RSV infection and asthma...
  82. pmc Subgroup prevalence and genotype circulation patterns of human respiratory syncytial virus in Belgium during ten successive epidemic seasons
    Kalina T Zlateva
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Clin Microbiol 45:3022-30. 2007
    ..Among five patients with homologous reinfections, only one was caused by HRSV-B. Our results support the hypothesis that the overall prevalence of HRSV-A over HRSV-B could be due to a more-transient subgroup A-specific immune protection...
  83. pmc Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital Department of Virology, University of Turku, Turku, Finland
    J Clin Microbiol 40:4337-9. 2002
    ..The sensitivity of nasal swabs was comparable to that of nasopharyngeal aspirates for the detection of all major respiratory viruses except respiratory syncytial virus...
  84. pmc Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10
    M Connors
    Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5321-5. 1994
    ..It is possible that this process played a role in enhanced disease observed in infants and children immunized with FI-RSV...
  85. pmc Children with respiratory disease associated with metapneumovirus in Hong Kong
    J S Malik Peiris
    The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Emerg Infect Dis 9:628-33. 2003
    ..Phylogenetically, all HMPV virus strains from Hong Kong belonged to one of the two genetic lineages previously described. HMPV contributed to 441.6 hospital admissions per 100,000 population <6 years of age...
  86. pmc Respiratory syncytial virus-induced activation and migration of respiratory dendritic cells and subsequent antigen presentation in the lung-draining lymph node
    Michael V Lukens
    Department of Pediatrics, the Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    J Virol 83:7235-43. 2009
    ..Taken together, our data indicate that during RSV infections, at least three DC subsets might be involved during the activation of lymph node-homing naïve and memory CD4(+) and CD8(+) T cells...
  87. ncbi Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7
    N Sigurs
    Department of Pediatrics, Borås Central Hospital, Boras, Sweden
    Am J Respir Crit Care Med 161:1501-7. 2000
    ..The results support the theory that the RSV influences the mechanisms involved in the development of asthma and allergy in children...
  88. ncbi Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes
    Riny Janssen
    Laboratory for Toxicology, Pathology, and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 196:826-34. 2007
    ..Only a proportion of children infected with RSV require hospitalization. Because known risk factors for severe disease, such as premature birth, cannot fully explain differences in disease severity, genetic factors have been implicated...
  89. ncbi The Pediatric Investigators Collaborative Network on Infections in Canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestation
    Barbara J Law
    Department of Pediatrics and Child Health, University of Manitoba and the Winnipeg Health Sciences Center, Winnipeg, Canada
    Pediatr Infect Dis J 23:806-14. 2004
    ..This study sought to identify independent risk factors for hospitalization for RSV infection...
  90. pmc Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease
    Maria Florencia Delgado
    INFANT Foundation, Gavilan 94, Buenos Aires, Argentina
    Nat Med 15:34-41. 2009
    ..It also suggests that inactivated RSV vaccines may be rendered safe and effective by inclusion of TLR agonists in their formulation, and it identifies affinity maturation as a key factor for the safe immunization of infants...
  91. ncbi Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene
    Weidong Zhang
    Division of Allergy and Immunology Joy McCann Culverhouse Airway Disease Research Center, Department of Internal Medicine, University of South Florida, MDC 19 Rm 2536, 12901 Bruce B Downs Boulevard, Tampa, Florida 33612, USA
    Nat Med 11:56-62. 2005
    ..Thus, siNS1 nanoparticles may provide an effective inhibition of RSV infection in humans...
  92. ncbi Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 176:1733-40. 2006
    ..These findings are consistent with the hypothesis that RSV infection sensitizes the airway epithelium to subsequent viral and bacterial exposures by up-regulating TLRs and increasing their membrane localization...
  93. pmc Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab
    Qing Zhu
    Department of Infectious Disease Vaccines, MedImmune, Gaithersburg, Maryland, USA
    J Infect Dis 203:674-82. 2011
    ..Although palivizumab escape mutants have been generated in the laboratory, the development of resistant RSV in patients receiving palivizumab has not been reported previously...
  94. pmc Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation
    Nicholas W Lukacs
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 185:2231-9. 2010
    ..Thus, without TLR7-mediated responses, an altered immune environment ensued with a significant effect on airway epithelial cell remodeling and goblet cell hyper/metaplasia, leading to increased mucus production...
  95. ncbi The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children
    Eric A F Simoes
    Department of Pediatric Infectious Diseases, University of Colorado School of Medicine, and The Children s Hospital, Aurora, Colo, USA
    J Allergy Clin Immunol 126:256-62. 2010
    ..Although respiratory syncytial virus (RSV) lower respiratory tract infections (LRTIs) in early life are followed by later airway hyperreactivity, it is unclear whether there is a causal relationship between this and an atopic diathesis...
  96. ncbi Bovine respiratory syncytial virus infection
    Jean Francois Valarcher
    IVI Animal Health, Lärkbacken, 740 20 Vänge, Uppsala, Sweden
    Vet Res 38:153-80. 2007
    ..Knowledge gained from these studies has also provided the opportunity to develop safe, stable, live attenuated virus vaccine candidates...
  97. ncbi The histopathology of fatal untreated human respiratory syncytial virus infection
    Joyce E Johnson
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Mod Pathol 20:108-19. 2007
    ..These findings inform our understanding of RSV pathogenesis and may facilitate the development of new approaches for prevention and treatment...
  98. ncbi Respiratory syncytial virus-induced chemokine production: linking viral replication to chemokine production in vitro and in vivo
    Allison L Miller
    University of Michigan Medical School, Department of Pathology, Ann Arbor, Michigan 48109, USA
    J Infect Dis 189:1419-30. 2004
    ..Our results suggest that viral replication is necessary for optimal chemokine production...
  99. pmc CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection
    Debbie C P Lee
    Department of Respiratory Medicine and Centre for Respiratory Infection, National Heart and Lung Institute, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 84:8790-8. 2010
    ..This work highlights a critical role for natural regulatory T cells in regulating the adaptive and innate immune responses during the later stages of lung viral infections...
  100. ncbi Immunopathology of RSV infection: prospects for developing vaccines without this complication
    S van Drunen Littel-van den Hurk
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E3, Canada
    Rev Med Virol 17:5-34. 2007
    ..Maternal vaccination may be the optimal strategy to protect the very young infants...
  101. ncbi Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy--a review
    Yechiel Becker
    Department of Molecular Virology Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Virus Genes 33:235-52. 2006
    ..The gradual increase of sG molecules creates a gradient of fractalkine (FKN) which directs IL-5-activated eosinophils to the lungs of the patient...

Research Grants71

  1. Signaling in Airway Inflammation
    Roberto P Garofalo; Fiscal Year: 2013
    ..Our work will lay the foundation for future studies aimed at translating the findings from this project period into novel treatments for asthma. ..
  2. Sixth International Respiratory Syncytial Virus Symposium
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  3. IMMUNOGENETICS AND THE PATHOGENESIS OF RSV INFECTION
    John DeVincenzo; Fiscal Year: 2004
    ..With the help of this award, this goal can be achieved. ..
  4. Mucosal RSV vaccine using CpG oligodeoxynucleotides
    Gregory Prince; Fiscal Year: 2003
    ..Phase II activities would use that information to formulate a vaccine that would be both effective and safe. ..
  5. Pathogenesis of RSV disease in the Elderly
    Edward Walsh; Fiscal Year: 2008
    ..abstract_text> ..
  6. IMPROVEMENT OF THE COTTON RAT MODEL OF HUMAN DISEASES
    Gregory Prince; Fiscal Year: 2002
    ..The proposed workscope of this application is to develop a library of reagents directed against cotton rat cell-surface antigens, cytokines and chemokines. ..
  7. Novel Model to Predict Safety and Efficacy of Microbicides
    Gregory Prince; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. PRIMARY HHV6 INFECTION--CLINICAL & VIRAL CHARACTERISTICS
    Caroline Hall; Fiscal Year: 2001
    ..A matched subgroup of 180 (90 with seizures from HHV-6 and 90 with seizures not from HHV-6) will be compared for neurologic development after 3 years by neurologic examinations and standardized neuropsychologic testing. ..
  9. Congenital HHV6 Infection: Characteristics and Outcome
    Caroline Hall; Fiscal Year: 2007
    ..Correlation of these measurements with the viral and clinical characteristics in Aim I may allow early identification of risk factors that are predictive of future disabilities. ..
  10. CONTROL OF EPIDEMIC INFLUENZA
    PEDRO PIEDRA; Fiscal Year: 2007
    ..abstract_text> ..
  11. The Role of a Novel Coronavirus In Kawasaki Disease
    Jeffrey Kahn; Fiscal Year: 2007
    ..We have identified a novel human virus, designated the New Haven coronavirus that is associated with KD. The goals of this study is to investigate the role of this novel virus in KD. [unreadable] [unreadable]..
  12. Human T Cells Responses to RSV
    James Crowe; Fiscal Year: 2006
    ..abstract_text> ..
  13. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..
  14. High Throughput Flow Cytometry Sorter
    James Crowe; Fiscal Year: 2004
    ..The requested instrument will meet all of these demonstrated needs. ..
  15. Respiratory Syncytial Virus Nanoparticle Vaccines
    James Crowe; Fiscal Year: 2008
    ..The development of a new technology for vaccination using nanoparticles also could have wide impact, since such a vaccine technology might be useful in developing vaccines against other infections. [unreadable] [unreadable] [unreadable]..
  16. ONTOGENY OF RSV-SPECIFIC B CELL RESPONSES IN HUMANS
    James Crowe; Fiscal Year: 2001
    ..The data from this work will direct decisions about the best vaccine strategy to use against RSV in neonates, and will delineate basic mechanisms of the ontogeny of B-cell repertoire diversity in humans. ..
  17. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
    ..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
  18. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2008
    ..abstract_text> ..
  19. AADRC -- Mechanisms of Virus-Induced Asthma
    James Gern; Fiscal Year: 2005
    ..It is proposed that these collaborative studies will provide new insight into mechanisms of respiratory-virus-induced asthma, the possible role of diminished IFN-gamma production in this process, and possibilities for new treatment...
  20. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2008
    ..abstract_text> ..
  21. Human Antibody Responses to Rotavirus
    James Crowe; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. Cell-Mediated Immune Responses to Vaccinia Viruses
    James Crowe; Fiscal Year: 2006
    ..We will examine many of these questions by taking advantage of new technology that allows for examination of T cell responses at the single cell level, and in an immunodominant epitope specific manner. [unreadable] [unreadable]..
  23. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  24. Alphavirus-based Vaccine for Prevention of MPV Infection
    James Crowe; Fiscal Year: 2008
    ..The consortium submitting this application brings together an experienced investigator group with expertise in pneumovirus and alphavirus virology, immunology, and vaccine development. ..
  25. Novel methods for generation of human B cell hybridomas
    James Crowe; Fiscal Year: 2005
    ..abstract_text> ..
  26. Immunomodulation on the Nanoscale (RMI)
    James Crowe; Fiscal Year: 2004
    ..Immunology and infectious diseases. 2. Materials science, especially nanoparticles, nanowires, and nanofluidics. 3. Instrumented platforms for cellular imaging and control. 4. Biocomputing. ..
  27. HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE VACCINIA
    James Crowe; Fiscal Year: 2002
    ..In summary, this work will yield a safe and effective immunotherapeutic strategy for treatment of vaccinia complications. ..
  28. Establishment fo HIV infection in cotton rats
    Jorge Blanco; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2007
    ..The study should provide new and useful information -- both for our understanding of RSV pathogenesis and for the development of an effective RSV vaccine. ..
  31. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2007
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..
  32. 2-5A Antisense for Degradation of SARS Coronavirus RNA
    Hagen Cramer; Fiscal Year: 2004
    ..We propose to develop an effective and marketable 2-5A antisense drug for the treatment of SARS infection. ..
  33. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2007
    ..abstract_text> ..
  34. IKK-NF-kB pathways in viral-induced lung inflammation
    Roberto Garofalo; Fiscal Year: 2004
    ..abstract_text> ..
  35. Increasing 2-5A effectiveness through better chemistry
    Hagen Cramer; Fiscal Year: 2003
    ..Ridgeway Biosystems Inc. will apply successful chemical modifications to other therapeutics currently under development. ..
  36. Immunobiology of Influenza Virus Infection: Approaches for an Emerging Zoonotic D
    Ralph Tripp; Fiscal Year: 2007
    ..abstract_text> ..
  37. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2003
    ..abstract_text> ..
  38. Treatment of RSV Bronchiolitis with NSAIDs
    Jorge Blanco; Fiscal Year: 2006
    ..These studies will involve correlating treatment of RSV-infected animals with pulmonary histopathology and inflammation. [unreadable] [unreadable] [unreadable]..
  39. Respiratory Viruses and Airflow Obstruction after HCT
    Michael Boeckh; Fiscal Year: 2008
    ..These studies will improve our understanding of the interaction between respiratory viruses and late pulmonary complications after HCT, which will ultimately enable us to formulate more rational treatment strategies. ..
  40. Comparative Safety and Effectiveness of Stimulants in Medicaid Youth with ADHD
    Almut G Winterstein; Fiscal Year: 2010
    ....
  41. DEVELOPMENT OF A NOVEL MULTIENVELOPE AIDS VACCINE
    JULIA HURWITZ; Fiscal Year: 2004
    ..Project 4 (K. Slobod) builds on these studies, initiating clinical trials of the safety and effectiveness of vaccines comprised of combinations of immunogenic envelopes. ..
  42. HIV-envelope-specific CD4+ T-cell activation and functional potentials
    Julia L Hurwitz; Fiscal Year: 2010
    ..Results from these experiments may be invaluable to the construction of new, successful HIV-1 vaccines designed to capture the full potentials of the immune response. ..
  43. Impact of the interferon regulated proteins XAF1 and ZNF313 on innate immunity
    Douglas W Leaman; Fiscal Year: 2010
    ....
  44. Antibody inhibition of respiratory syncytial virus G protein activity
    Ralph A Tripp; Fiscal Year: 2010
    ..abstract_text> ..
  45. Molecular Mediators of Interferon induced Apoptosis
    Douglas Leaman; Fiscal Year: 2005
    ..The results of these studies should provide important information on the molecular details of antitumor activity of IFNs that can be used to identify or develop targeted therapeutics that augment IFN effects. ..
  46. Role of EGFR in Viral Infected Lung Epithelial Cells
    Martha M Monick; Fiscal Year: 2010
    ..Completion of these studies will add to our understanding of mechanisms of RSV infection of airway epithelium and the role of targeted signaling pathways in the subsequent inflammation and life span of infected cells. ..
  47. MARROW TRANSPLANT IN CANCER THERAPY T CELL RECOVERY
    JULIA HURWITZ; Fiscal Year: 2001
    ..Jude Children's Research Hospital (SJCRH), predicting successful implementation of the proposed studies. ..
  48. 2-5A Antisense Targeting of Telomerase RNA
    Douglas Leaman; Fiscal Year: 2003
    ..These studies will also impact other antisense products under development by improving the effectiveness of the 2-A antisense technology. ..
  49. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2006
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  50. Screening for Rnase L Activators
    Hagen Cramer; Fiscal Year: 2004
    ..The successful completion of this proposed project will open a whole new class of therapy for currently intractable cancer and viral infections leveraging an important pathway of the body's natural immunity. ..
  51. Alteration of Human Dendritic Cell Subsets by RSV
    Michelle Gill; Fiscal Year: 2008
    ..This award will facilitate the transition of the candidate into an independent, academic physician scientist. ..
  52. MECHANISM OF ETHANOL INDUCED IMPAIRMENTS IN IMMUNITY
    THOMAS JERRELLS; Fiscal Year: 2002
    ..By using the various infectious model systems in place in this laboratory the ETOH-mediated effects on the subsets of helper T cells (TH-1 and TH-2) will also be defined. ..
  53. RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASE
    R Peebles; Fiscal Year: 2003
    ....
  54. A ROLE FOR VIRAL INFECTION IN ALCOHOLIC PANCREATITIS
    THOMAS JERRELLS; Fiscal Year: 2005
    ..The model system will also allow critical studies of possible therapeutic interventions. ..
  55. A HUMAN MONOCLONAL COCKTAIL FOR RSV IMMUNOTHERAPY
    Larry Zeitlin; Fiscal Year: 2007
    ..Availability of these drugs would also reduce the chance of resistant strains developing. [unreadable] [unreadable] [unreadable]..
  56. BETAZAR POLYMORPHISMS AND AIRWAY SMOOTH MUSCLE
    Paul Moore; Fiscal Year: 2004
    ..Defining the beta2-AR genotypes that alter beta-agonist responses may thus have significant therapeutic consequences on the use of beta-agonists. ..
  57. BIOCHEMISTRY AND IMMUNOLOGY OF ALCOHOLIC LIVER DISEASE
    THOMAS JERRELLS; Fiscal Year: 2004
    ..The ultimate goal of this training program is to prepare both basic scientists and clinically trained scientists for an active and productive research career on the effects of alcohol on the liver. ..
  58. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
    ..Specific Aim 4: To determine if this multiplex assay is equivalent to these "singleplex" assays in a clinical trial. ..
  59. Viral-Bacterial Interactions in the Airway Epithelium
    Raymond Pickles; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  60. Ultrafine Particle Exposure in Humans
    Mark Frampton; Fiscal Year: 2005
    ..These studies will identify key mechanisms for the cardiovascular effects of exposure to ambient air particles. ..
  61. Asthma Clinical Research Network-Washington University
    Mario Castro; Fiscal Year: 2007
    ..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
  62. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  63. Chlipoplex Nanoparticle Prophylactics for RSV Infection
    Shyam Mohapatra; Fiscal Year: 2004
    ..abstract_text> ..
  64. Chliposome IFN-gamma-pDNA Naoparticle Therapy for Asthma
    Shyam Mohapatra; Fiscal Year: 2004
    ..The results of the proposed research are expected to advance our knowledge of the mechanisms of asthma and may lead to the development of an effective approach for the prevention and/or treatment of asthma. ..
  65. DENDRITIC CELLS, RSV AND INFLUENZA INFECTION IN CHILDREN
    Octavio Ramilo; Fiscal Year: 2005
    ..abstract_text> ..
  66. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2006
    ..abstract_text> ..
  67. Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic Asthma
    Shyam Mohapatra; Fiscal Year: 2006
    ..It is anticipated that the results of these studies will contribute significantly to our knowledge of asthma and CIN therapy may provide a major breakthrough in management of asthma. ..
  68. Mentored Patient-Oriented Research Career Development Award
    Ruey Kang Chang; Fiscal Year: 2006
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  69. Na+ TRANSPORT INHIBITION BY RESPIRATORY SYNCYTIAL VIRUS
    Ian Davis; Fiscal Year: 2007
    ..abstract_text> ..
  70. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2005
    ..4) explore the role of attachment in initiation of fusion. ..