avian leukosis

Summary

Summary: A group of transmissible viral diseases of chickens and turkeys. Liver tumors are found in most forms, but tumors can be found elsewhere.

Top Publications

  1. pmc Assessing the roles of endogenous retrovirus EAV-HP in avian leukosis virus subgroup J emergence and tolerance
    Melanie A Sacco
    Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    J Virol 78:10525-35. 2004
  2. ncbi The PI3K/Akt pathway is involved in early infection of some exogenous avian leukosis viruses
    Shao Zhen Feng
    Key Laboratory of Animal Disease Control and Prevention of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China
    J Gen Virol 92:1688-97. 2011
  3. ncbi E (XSR) element contributes to the oncogenicity of Avian leukosis virus (subgroup J)
    Peter M Chesters
    Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 87:2685-92. 2006
  4. ncbi Cardiomyopathy in broiler chickens congenitally infected with avian leukosis virus subgroup J
    N L Stedman
    Athens Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, 30602, USA
    Vet Pathol 39:161-4. 2002
  5. ncbi c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor
    T W Nilsen
    Cell 41:719-26. 1985
  6. ncbi Comparison of serological and virological findings from subgroup J avian leukosis virus-infected neoplastic and non-neoplastic flocks in Israel
    Mertyn Malkinson
    Kimron Veterinary Institute, Beit Dagan 50250, Israel
    Avian Pathol 33:281-7. 2004
  7. ncbi Pathogenicity of two recombinant avian leukosis viruses
    Blanca Lupiani
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 47:425-32. 2003
  8. ncbi Neoplastic diseases: Marek's disease, avian leukosis and reticuloendotheliosis
    L N Payne
    Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Rev Sci Tech 19:544-64. 2000
  9. ncbi In ovo infection with an avian leukosis virus causing fowl glioma: viral distribution and pathogenesis
    Y Tomioka
    Laboratory of Comparative Pathology, Hokkaido University, Sapporo, Japan
    Avian Pathol 32:617-24. 2003
  10. ncbi Development and characterization of monoclonal antibodies to subgroup J avian leukosis virus
    A Qin
    USDA Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Dis 45:938-45. 2001

Research Grants

  1. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
  2. Oncogenes and oncogenic microRNAs in chicken tumors
    Karen L Beemon; Fiscal Year: 2012
  3. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2009
  4. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 2001
  5. POSSIBLE OF ROLE OF AVIAN RETROVIRUSES IN HUMAN CANCER
    Eric Johnson; Fiscal Year: 2002
  6. Technology to Optimize scFvs for Targeting Therapeutics
    MARK FEDERSPIEL; Fiscal Year: 2007
  7. BIOCHEMISTRY OF RNA TUMOR VIRUS REPLICATION
    RALPH SMITH; Fiscal Year: 1990
  8. ONCOGENE ACTIVATION IN B AND T LYMPHOCYTES
    Hsing Jien Kung; Fiscal Year: 2000
  9. RETROVIRUS-HOST INTERACTIONS
    Harriet Robinson; Fiscal Year: 1992
  10. WORKSHOP ON PATHOGENESIS BY NON-ACUTE RETROVIRUSES
    Hung Fan; Fiscal Year: 1992

Detail Information

Publications182 found, 100 shown here

  1. pmc Assessing the roles of endogenous retrovirus EAV-HP in avian leukosis virus subgroup J emergence and tolerance
    Melanie A Sacco
    Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    J Virol 78:10525-35. 2004
    b>Avian leukosis virus (ALV) subgroup J is thought to have emerged through a recombination event between an unknown exogenous ALV and the endogenous retrovirus elements designated EAV-HP...
  2. ncbi The PI3K/Akt pathway is involved in early infection of some exogenous avian leukosis viruses
    Shao Zhen Feng
    Key Laboratory of Animal Disease Control and Prevention of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China
    J Gen Virol 92:1688-97. 2011
    b>Avian leukosis virus (ALV) is an enveloped and oncogenic retrovirus. Avian leukosis caused by the members of ALV subgroups A, B and J has become one of the major problems challenging the poultry industry in China...
  3. ncbi E (XSR) element contributes to the oncogenicity of Avian leukosis virus (subgroup J)
    Peter M Chesters
    Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 87:2685-92. 2006
    Among the six subgroups of Avian leukosis virus (ALV) that infect chickens, subgroup J (ALV-J) was isolated from meat-type chickens where it predominantly induces myeloid leukosis (ML) and erythroblastosis (EB)...
  4. ncbi Cardiomyopathy in broiler chickens congenitally infected with avian leukosis virus subgroup J
    N L Stedman
    Athens Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, 30602, USA
    Vet Pathol 39:161-4. 2002
    ..are frequently associated with rapid growth and pulmonary hypertension, but can be associated with some avian leukosis virus (ALV) infections...
  5. ncbi c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor
    T W Nilsen
    Cell 41:719-26. 1985
    ..These results establish a novel pathway of promoter insertion oncogenesis that stands in contrast to the pathways used in the activation of c-myc in B lymphomas...
  6. ncbi Comparison of serological and virological findings from subgroup J avian leukosis virus-infected neoplastic and non-neoplastic flocks in Israel
    Mertyn Malkinson
    Kimron Veterinary Institute, Beit Dagan 50250, Israel
    Avian Pathol 33:281-7. 2004
    ..leukosis tumours (ML+) and four tumour-free flocks from the same commercial background (ML-) were compared for avian leukosis virus subgroup J (ALV-J) serum antibodies by enzyme-linked immunosorbent assay (ELISA), for antigenemia (group-..
  7. ncbi Pathogenicity of two recombinant avian leukosis viruses
    Blanca Lupiani
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 47:425-32. 2003
    We have recently described the isolation and molecular characteristics of two recombinant avian leukosis subgroup J viruses (ALV J) with an avian leukosis virus subgroup A envelope (r5701A and r6803A)...
  8. ncbi Neoplastic diseases: Marek's disease, avian leukosis and reticuloendotheliosis
    L N Payne
    Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Rev Sci Tech 19:544-64. 2000
    ..Marek's disease virus (MDV) and avian leukosis viruses (ALVs) are prevalent throughout the world, and new strains which arise in particular locations may ..
  9. ncbi In ovo infection with an avian leukosis virus causing fowl glioma: viral distribution and pathogenesis
    Y Tomioka
    Laboratory of Comparative Pathology, Hokkaido University, Sapporo, Japan
    Avian Pathol 32:617-24. 2003
    We have previously isolated an avian leukosis virus (ALV) from a chicken affected with so-called fowl glioma. A resistance-inducing factor test indicated that the isolate was classified into a subgroup A...
  10. ncbi Development and characterization of monoclonal antibodies to subgroup J avian leukosis virus
    A Qin
    USDA Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Dis 45:938-45. 2001
    In an attempt to develop a specific diagnostic test for avian leukosis virus (ALV) subgroup J (ALV-J) strain Hc1, four monoclonal antibodies (MAbs), JE9, G2, 145, and J47, were generated that are specific for ALV-J envelope glycoprotein, ..
  11. ncbi The feather tips of commercial chickens are a favorable source of DNA for the amplification of Marek's disease virus and avian leukosis virus, subgroup J
    Irit Davidson
    Division of Avian and Fish Diseases, Kimron Veterinary Institute, P O Box 12, Bet Dagan 50250, Israel
    Avian Pathol 31:237-40. 2002
    Marek's disease virus (MDV), a herpesvirus, and avian leukosis virus, subgroup J (ALV-J), a retrovirus, are oncogenic viruses of poultry...
  12. ncbi [Emerging of avian leukosis virus subgroup J in a flock of Chinese local breed]
    Zi Qiang Cheng
    Animal Science and Technology College of Shandong Agricultural University, Tai an 271018, China
    Wei Sheng Wu Xue Bao 45:584-7. 2005
    ..The results indicate that ALV-J already caused chickens infection and dead in Chinese local breed...
  13. pmc Development of a loop-mediated isothermal amplification assay for rapid detection of subgroup J avian leukosis virus
    Xiaotao Zhang
    Key Laboratory of Animal Disease Control and Prevention of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou 510642, People s Republic of China
    J Clin Microbiol 48:2116-21. 2010
    Infection of breeder flocks in China with subgroup J avian leukosis virus (ALV-J) has increased recently...
  14. ncbi Detection of Avian leukosis virus genome by a nested polymerase chain reaction using DNA and RNA from dried feather shafts
    Hitoshi Hatai
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Diagn Invest 21:519-22. 2009
    ..using frozen feather pulp is useful for detecting fowl glioma-inducing virus (FGV), which belongs to the Avian leukosis virus family, and it has recently been suggested that FGV has spread to ornamental chickens kept in Japanese ..
  15. ncbi Simultaneous endemic infections with subgroup J avian leukosis virus and reticuloendotheliosis virus in commercial and local breeds of chickens
    Zhizhong Cui
    College of Veterinary Medicine, Shandong Agricultural University, Taian, China
    Avian Pathol 38:443-8. 2009
    Epidemiological studies of subgroup J avian leukosis virus (ALV-J) and reticuloendotheliosis virus (REV) infections were conducted during 1999 to 2009 on 29 chicken flocks of various commercial and local breeds located in six provinces in ..
  16. ncbi Avian erythroblastosis: a model system to study oncogene co-operation in leukemia
    M J Hayman
    Department of Microbiology, School of Medicine, State University of New York, Stony Brook 11794
    Cancer Surv 15:53-68. 1992
    ..Thus, the avian leukaemia virus model has taught us important lessons that will help us to understand the basic molecular mechanisms that give rise to human leukaemia...
  17. ncbi The long view: 40 years of avian leukosis research
    L N Payne
    2 Manor Green, Harwell, Didcot, Oxon, UK
    Avian Pathol 41:11-9. 2012
    ..The diseases of the avian leukosis complex have a number of features of distinction...
  18. pmc Molecular epidemiology of avian leukosis virus subgroup J in layer flocks in China
    Yulong Gao
    Division of Avian Infectious Diseases, State corrected Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
    J Clin Microbiol 50:953-60. 2012
    b>Avian leukosis virus subgroup J (ALV-J) was first isolated from meat-type chickens in 1988. No field cases of ALV-J infection or tumors in layer chickens were observed worldwide until 2004...
  19. ncbi Isolation and characterization of emerging subgroup J avian leukosis virus associated with hemangioma in egg-type chickens
    Hanzhang Lai
    College of Veterinary Medicine, South China Agricultural University, 483 Wushan Street, Tianhe District, Guangzhou, Guangdong Province 510642, People s Republic of China
    Vet Microbiol 151:275-83. 2011
    Subgroup J avian leukosis virus (ALV-J), first isolated in 1989, predominantly causes myeloid leukosis (ML) in meat-type or egg-type chicken...
  20. ncbi A low incidence of histiocytic sarcomatosis associated with infection of chickens with the HPRS-103 strain of subgroup J avian leukosis virus
    S S Arshad
    Institute for Animal Health, Newbury, Berkshire, England
    Avian Dis 41:947-56. 1997
    ..proliferative lesions in meat-type chickens associated in low incidence with infection by subgroup J avian leukosis virus (ALV) are described...
  21. pmc Recombinant avian leukosis viruses of subgroup J isolated from field infected commercial layer chickens with hemangioma and myeloid leukosis possess an insertion in the E element
    Xiaoping Wu
    Key Lab of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, No 12 East Wenhui Road, Yangzhou, Jiangsu Province, China, 225009
    Vet Res Commun 34:619-32. 2010
    Five isolates (JS09GY2, JS09GY3, JS09GY4, JS09GY5, and JS09GY6) of avian leukosis virus subgroup J (ALV-J) were isolated from six infected commercial layer flocks displaying both hemangioma and myeloid leukosis (ML), which shared the same ..
  22. pmc Sequence analysis for the complete proviral genome of subgroup J Avian Leukosis virus associated with hemangioma: a special 11 bp deletion was observed in U3 region of 3'UTR
    Min Shi
    College of Veterinary Medicine, Sichuan Agricultural University, Ya an, Sichuan 625014, China
    Virol J 8:158. 2011
    b>Avian Leukosis virus (ALV) of subgroup J (ALV-J) belong to retroviruses, which could induce tumors in domestic and wild birds...
  23. ncbi Phylogenetic analysis of subgroup J avian leucosis virus from broiler and native chickens in Taiwan during 2000-2002
    Wen Liang Thu
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    J Vet Med Sci 65:325-8. 2003
    ..The high similarities observed in different ALV-J isolates suggest that different ALV-Js were mixed in the pedigree generations in different breeding lines...
  24. ncbi Detection of avian leukosis virus subgroup J in chicken flocks from Malaysia and their molecular characterization
    B R Thapa
    Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia
    Avian Pathol 33:359-63. 2004
    Previously we have shown that avian leukosis virus subgroup J (ALV-J) might be present in chicken flocks from Malaysia based on serological study and also on detection of tissue samples with myelocytic infiltration...
  25. ncbi Intraembryonic avian leukosis virus subgroup C (ALV-C) inoculation producing wasting disease in ducks soon after hatching
    V Stepanets
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Folia Biol (Praha) 49:100-9. 2003
    ..On the basis of these and additional observations we propose that inoculation of duck embryos provides a suitable model for analysis of the wasting disease produced by ALV-C...
  26. ncbi Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China
    Ziqiang Cheng
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai an, PR China
    J Vet Med Sci 72:1027-33. 2010
    In the 3 years leading up to November 2009, 6 different types of naturally occurring neoplasms associated with avian leukosis virus subgroup J (ALV-J) were diagnosed by histopathology, polymerase chain reaction (PCR) and ..
  27. ncbi Molecular indications for in vivo integration of the avian leukosis virus, subgroup J-long terminal repeat into the Marek's disease virus in experimentally dually-infected chickens
    I Davidson
    Division of Avian Diseases, Kimron Veterinary Institute, Bet Dagan, Israel
    Virus Genes 24:173-80. 2002
    Marek's disease virus, a herpesvirus, and avian leukosis virus, subgroup J, a retrovirus, are oncogenic viruses of poultry. Both viruses may infect the same flock, the same bird and the same cell...
  28. ncbi Locus-specific diagnostic tests for endogenous avian leukosis-type viral loci in chickens
    B F Benkel
    Agriculture and Agri Food Canada, Centre for Food and Animal Research, Ottawa, Ontario
    Poult Sci 77:1027-35. 1998
    ..endogenous proviral elements (ALVE elements or ev genes) that display a high degree of similarity to the Avian Leukosis class of retroviruses. The ALVE proviruses are known to modulate physiological processes of the host birds...
  29. ncbi A recombinant avian leukosis virus associated with fowl glioma in layer chickens in Japan
    Hitoshi Hatai
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Avian Pathol 37:127-37. 2008
    ..glioma is characterized by multiple nodular growth of astrocytes, and fowl glioma-inducing virus belonging to avian leukosis virus has been isolated from Japanese bantam as a causal agent...
  30. ncbi Susceptibility of various parental lines of commercial white leghorn layers to infection with a naturally occurring recombinant avian leukosis virus containing subgroup B envelope and subgroup J long terminal repeat
    Jody K Mays
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 50:342-7. 2006
    ..White Leghorn layer flocks from three independent breeders were inoculated with a naturally occurring avian leukosis virus (ALV) containing an ALV-B envelope and an ALV-J long terminal repeat (LTR) termed ALV-B/J...
  31. ncbi Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China
    Binrui Xu
    College of Veterinary Medicine, China Agricultural University, Beijing, China
    Avian Pathol 33:13-7. 2004
    ..Immunohistochemical studies with a monoclonal antibody to gp85 of avian leukosis virus subgroup J (ALV-J) revealed antigen in all organs examined...
  32. ncbi Molecular epidemiology of avian leukosis virus subgroup J and evolutionary history of its 3' untranslated region
    G Zavala
    Poultry Diagnostic and Research Center, Department of Population Health, University of Georgia, Athens, GA 30602, USA
    Avian Dis 51:942-53. 2007
    b>Avian leukosis subgroup J (ALV-J) causes a variety of tumors and mortality in meat-type chickens...
  33. ncbi Major rearrangements in the E element and minor variations in the U3 sequences of the avian leukosis subgroup J provirus isolated from field myelocytomatosis
    D Hue
    UPR 1282, INRA, Centre de Recherches de Tours, Nouzilly, France
    Arch Virol 151:2431-46. 2006
    We collected paraffin-embedded myelocytomatoses induced by subgroup J avian leukosis virus (ALV-J) in French poultry from 1992 to 2000...
  34. ncbi Epidemiological and pathological studies of subgroup J avian leukosis virus infections in Chinese local "yellow" chickens
    Shuhong Sun
    College of Veterinary Medicine, Shandong Agricultural University, Taian, Peoples Republic of China
    Avian Pathol 36:221-6. 2007
    Epidemiological, pathological and molecular studies indicate that subgroup J avian leukosis virus (ALV-J) infections are widely spread in "yellow chickens" of local breeds in China...
  35. pmc Telomerase reverse transcriptase expression elevated by avian leukosis virus integration in B cell lymphomas
    Feng Yang
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 104:18952-7. 2007
    ..In this study, we identified avian leukosis virus (ALV) proviral integration sites in rapid-onset B cell lymphomas arising <12 weeks after infection of ..
  36. ncbi Detection of subgroup J avian leukosis virus infection in Australian meat-type chickens
    T J Bagust
    School of Veterinary Science, The University of Melbourne, Parkville, Victoria
    Aust Vet J 82:701-6. 2004
    To determine the extent of avian leukosis virus subgroup J (ALV-J) infection in Australian broiler breeder flocks, using virus isolation and molecular biological detection...
  37. ncbi Response of white leghorn chickens of various genetic lines to infection with avian leukosis virus subgroup J
    Susan M Williams
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 48:61-7. 2004
    ..1, chickens from various white leghorn experimental lines were inoculated with strain ADOL-Hcl of subgroup J avian leukosis virus (ALV-J) either as embryos or at 1 day of age...
  38. pmc Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis
    Wayne Tam
    Graduate Program in Molecular Biology, Joan and Sanford Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    J Virol 76:4275-86. 2002
    bic is a novel gene identified at a common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated as a collaborator with c-myc in B lymphomagenesis...
  39. ncbi Influence of strain, dose of virus, and age at inoculation on subgroup J avian leukosis virus persistence, antibody response, and oncogenicity in commercial meat-type chickens
    Arun R Pandiri
    U S Department of Agriculture Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 51:725-32. 2007
    The effects of viral strain, viral dose, and age of bird at inoculation on subgroup J avian leukosis virus (ALV J) persistence, neutralizing antibody (VNAb) response, and tumors were studied in commercial meat-type chickens...
  40. ncbi Diagnosis of myeloid leukosis induced by a recombinant avian leukosis virus in commercial white leghorn egg laying flocks
    Eric Gingerich
    University of Pennsylvania, New Bolton Center Poultry Laboratory, Kennett Square 19348 1692, USA
    Avian Dis 46:745-8. 2002
    ..The diagnosis of myeloid leukosis was confirmed by the isolation of a recombinant avian leukosis virus (ALV) containing the LTR of subgroup J and the envelope of subgroup B ALV...
  41. ncbi Response of white leghorn chickens of various B haplotypes to infection at hatch with subgroup J avian leukosis virus
    Jody K Mays
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 49:214-9. 2005
    ..B semicongenic lines were infected at hatch with strain ADOL Hc-1 of subgroup J avian leukosis virus (ALV-J)...
  42. ncbi Molecular and biological characterization of a naturally occurring recombinant subgroup B avian leukosis virus with a subgroup J-like long terminal repeat
    Blanca Lupiani
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Avian Dis 50:572-8. 2006
    Infection of broiler chickens with subgroup J avian leukosis virus (ALV) results in the induction of myeloid tumors...
  43. ncbi Effect of an in ovo infection with a Dutch avian leukosis virus subgroup J isolate on the growth and immunological performance of SPF broiler chickens
    W J M Landman
    Animal Health Service, Poultry Health Centre, Deventer, The Netherlands
    Avian Pathol 31:59-72. 2002
    The effect of an in ovo infection with a Dutch isolate of avian leukosis virus subgroup J (ALV-J) on the growth of specific pathogen free (SPF) broiler chickens was analysed...
  44. ncbi The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively
    P M Chesters
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 83:2553-61. 2002
    Among the six envelope subgroups of avian leukosis virus (ALV) that infect chickens, subgroups A (ALV-A) and J (ALV-J) are the most pathogenic and widespread among commercial chicken populations...
  45. ncbi Methods for evaluating and developing commercial chicken strains free of endogenous subgroup E avian leukosis virus
    L D Bacon
    US Department of Agriculture Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Pathol 33:233-43. 2004
    The genome of nearly all chickens contains various DNA proviral insertions of retroviruses of subgroup E avian leukosis virus (ALVE)...
  46. ncbi Development of an endogenous virus-free line of chickens susceptible to all subgroups of avian leukosis virus
    Huanmin Zhang
    U S Department of Agriculture, Agriculture Research Service, Avian Disease and Oncology Laboratory, 3606 E Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 52:412-8. 2008
    ..are used for detection of contamination of adult or embryonic tissues, meconium, or tissue culture fluids with avian leukosis viruses (ALV)...
  47. pmc Identification of key residues in subgroup A avian leukosis virus envelope determining receptor binding affinity and infectivity of cells expressing chicken or quail Tva receptor
    S L Holmen
    Molecular Medicine Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Virol 75:726-37. 2001
    To better understand retroviral entry, we have characterized the interactions between subgroup A avian leukosis virus [ALV(A)] envelope glycoproteins and Tva, the receptor for ALV(A), that result in receptor interference...
  48. ncbi Polymerase chain reaction for detection of avian leukosis virus subgroup J in feather pulp
    Guillermo Zavala
    Department of Avian Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA
    Avian Dis 46:971-8. 2002
    ..infected chickens was used as a source of DNA for polymerase chain reaction (PCR) amplification of avian leukosis virus subgroup J (ALV-J) proviral DNA...
  49. ncbi High virus titer in feather pulp of chickens infected with subgroup J avian leukosis virus
    H W Sung
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Dis 46:281-6. 2002
    Subgroup J avian leukosis viruses (ALVs), which are a recombinant virus between exogenous and endogenous ALVs, can spread by either vertical or horizontal transmission. Exogenous and endogenous ALVs can be detected in feather pulp...
  50. pmc Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses
    Daniel Elleder
    Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague
    J Virol 78:13489-500. 2004
    ..Line 7(2) tva(r2) contains a 4-bp insertion in exon 1 that causes a change in the reading frame, which blocks expression of the Tva receptor...
  51. ncbi Serologic profiles of chickens infected with subgroup J avian leukosis virus
    Chyi Sing Hwang
    Department of Veterinary Medicine, National Taiwan University, Taipei
    Avian Dis 46:598-604. 2002
    Subgroup J avian leukosis virus (ALV-J) causes serious economic losses in the commercial poultry industry...
  52. ncbi Myotropic avian leukosis virus subgroup J infection in a chicken
    G Sironi
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
    J Vet Med B Infect Dis Vet Public Health 53:347-9. 2006
    The study describes a highly productive myotropic avian leukosis virus infection (ALV) in a 3-month-old female chicken. At necropsy, ascites, hepatic fibrosis and cardiomegaly were seen...
  53. ncbi Tissue tropism and bursal transformation ability of subgroup J avian leukosis virus in White Leghorn chickens
    Susan M Williams
    USDA Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 48:921-7. 2004
    In Experiment 1, a monoclonal antibody against the envelope glycoprotein (gp85) of subgroup J avian leukosis virus (ALV-J) was used to study the distribution of ALV-J in various tissues of White Leghorn chickens inoculated as embryos with ..
  54. ncbi Single and concurrent avian leukosis virus infections with avian leukosis virus-J and avian leukosis virus-A in Australian meat-type chickens
    Simon P Fenton
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3052, Australia
    Avian Pathol 34:48-54. 2005
    Australian broiler breeders were screened for avian leukosis viruses (ALVs) (May 2001 to December 2003) as surveillance of measures to reduce the prevalence of ALV-J...
  55. ncbi Reduced serologic response to Newcastle disease virus in broiler chickens exposed to a Chinese field strain of subgroup J avian leukosis virus
    Zhizhong Cui
    Department of Preventive Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, P R China
    Avian Dis 50:191-5. 2006
    In this study, a Chinese field strain of subgroup J avian leukosis virus (ALV-J), NX0101, was studied for its immunosuppressive effects in both commercial broilers and SPF white Leghorn chickens infected at 1 day of age...
  56. ncbi Differences in pathogenicity among strains of the same or different avian leukosis virus subgroups
    Dana Pruková
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam 2, CZ 166 37, Prague 6, Czech Republic
    Avian Pathol 36:15-27. 2007
    An efficient induction of wasting disease in chickens by avian leukosis virus (ALV), particularly ALV subgroup C, requires >102 infectious units virus inoculated in mid embryogenesis...
  57. ncbi Seroprevalence of avian influenza virus, infectious bronchitis virus, reovirus, avian pneumovirus, infectious laryngotracheitis virus, and avian leukosis virus in Nigerian poultry
    A A Owoade
    Department of Veterinary Medicine, University of Ibadan, Nigeria
    Avian Dis 50:222-7. 2006
    ..reovirus, avian pneumovirus (APV), infectious laryngotracheitis virus (ILTV), avian influenza virus (AIV), and avian leukosis virus (ALV)...
  58. ncbi Fertility and sperm quality of broiler breeder males infected with subgroup J avian leukosis virus
    Benton P Hudson
    Department of Poultry Science, The University of Georgia, Athens, GA 30602 4875, USA
    Avian Dis 46:1033-7. 2002
    In order to assess the effects of subgroup J avian leukosis virus (ALV-J) on semen quality, broiler breeder males were separated by ALV-J status (ALV-J positive = POS, ALV-J negative = NEG) at 44 wk of age...
  59. ncbi Experimental infection with avian leukosis virus isolated from Marek's disease vaccines
    Guillermo Zavala
    Department of Population Health, University of Georgia, Athens 30602, USA
    Avian Dis 50:232-7. 2006
    Recently, avian leukosis virus (ALV) was isolated from four lots of Marek's disease vaccine produced by two laboratories...
  60. ncbi Development and application of reverse transcriptase nested polymerase chain reaction test for the detection of exogenous avian leukosis virus
    Maricarmen Garcia
    Department of Avian Medicine, Poultry Diagnostic and Research Center, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 4875, USA
    Avian Dis 47:41-53. 2003
    ..PCR) assay that utilizes nested primers to amplify a fragment of the long terminal repeat of exogenous avian leukosis virus (ALV) was developed and evaluated for detection of ALV subgroup J directly from clinical samples...
  61. doi A diagnostic assay for the endogenous ALV-type provirus ALVE-NSAC-3 of chickens
    A Smith
    Department of Plant and Animal Sciences, Nova Scotia Agricultural College, Truro, NS, Canada
    Anim Genet 39:574-5. 2008
  62. ncbi Occurrence of subgroup J avian leukosis virus in Taiwan
    C H Wang
    Department of Veterinary Medicine, National Taiwan University, P O Box 23 3, Taipei 106, Taiwan
    Avian Pathol 31:435-9. 2002
    ..One of these farms, populated by breast meat yield chickens (yield type), suffered from a severe subgroup J avian leukosis virus (ALV-J) infection in mid-1997...
  63. ncbi Persistence of chicken herpesvirus and retroviral chimeric molecules upon in vivo passage
    R Borenshtain
    Division of Avian Diseases, Kimron Veterinary Institute, Bet Dagan, P O Box 12, Israel 50250
    Avian Dis 47:296-308. 2003
    ..The findings show that, in four out of seven groups of the second trial, the chimeric molecule species persisted on passage...
  64. ncbi Isolation and characterization of an adventitious avian leukosis virus isolated from commercial Marek's disease vaccines
    Aly Fadly
    USDA, Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, Michigan 48823, USA
    Avian Dis 50:380-5. 2006
    ..Marek's disease (MD) vaccines produced by two manufacturers were tested for possible contamination with avian leukosis virus (ALV)...
  65. ncbi Naturally occurring multiple perineuriomas in a chicken (Gallus domesticus)
    A Ochi
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Pathol 45:685-9. 2008
    ..On the basis of microscopic, histologic, and immunohistochemical findings, the tumors were diagnosed as multiple perineuriomas...
  66. ncbi Distribution of viral antigen gp85 and provirus in various tissues from commercial meat-type and experimental White Leghorn Line 0 chickens with different subgroup J avian leukosis virus infection profiles
    A R Pandiri
    USDA ARS Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Pathol 37:7-13. 2008
    Immunohistochemistry and polymerase chain reaction (PCR) were used to test for the presence of avian leukosis virus (ALV) J viral antigen gp85 and proviral DNA, respectively, in various tissues (adrenal gland, bone marrow, gonad, heart, ..
  67. ncbi [Avian leukosis subgroup J in broiler breeders in Switzerland]
    C A Wunderwald
    , ,
    Schweiz Arch Tierheilkd 143:411-8. 2001
    Since a new envelope subgroup (J) of the avian leukosis-sarcomatosis-complex was isolated for the first time from broiler breeders in the United Kingdom in 1989 and was characterized and associated with myeloid leukosis (syn...
  68. ncbi The effects of cyclophosphamide treatment on the pathogenesis of subgroup J avian leukosis virus (ALV-J) infection in broiler chickens with Marek's disease virus exposure
    Yongbaek Kim
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Vet Sci 5:49-58. 2004
    Studies were performed to determine the effects of Bcell suppression on the pathogenesis of Subgroup J avian leukosis virus (ALV-J) in broiler chickens...
  69. ncbi Heterophil function and resistance to staphylococcal challenge in broiler chickens naturally infected with avian leukosis virus subgroup J
    N L Stedman
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, 30602, USA
    Vet Pathol 38:519-27. 2001
    b>Avian leukosis virus subgroup J has a high tropism for myeloid lineage cells and frequently induces neoplastic transformation of myelocytes...
  70. pmc Quantitative evaluation of DNA methylation patterns for ALVE and TVB genes in a neoplastic disease susceptible and resistant chicken model
    Ying Yu
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA
    PLoS ONE 3:e1731. 2008
    Chicken endogenous viruses, ALVE (Avian Leukosis Virus subgroup E), are inherited as LTR (long terminal repeat) retrotransposons, which are negatively correlated with disease resistance, and any changes in DNA methylation may contribute ..
  71. ncbi Localization of avian leukosis virus subgroup J in naturally infected chickens by RNA in situ hybridization
    N L Stedman
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602-4875, USA
    Vet Pathol 38:649-56. 2001
    The novel subgroup J of avian leukosis virus (ALV-J) has emerged as a significant cause of myeloid neoplasia and weight suppression in broiler chickens...
  72. ncbi The effects of avian leukosis virus subgroup J on broiler chicken performance and response to vaccination
    E Spackman
    Southeast Poultry Research Lab, USDA, Agricultural Research Service, 934 College Station Road, Athens, GA 30605, USA
    Avian Dis 47:618-26. 2003
    The effects of avian leukosis virus subgroup J (ALV-J) infection on meat-type chickens reared in a simulated commercial setting were evaluated...
  73. ncbi Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis
    Sean S Parghi
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024, MS C2 023, Seattle, WA 98109, USA
    Oncogene 23:4413-21. 2004
    b>Avian leukosis virus (ALV) induces bursal lymphoma in tumor-susceptible chicken strains after proviral integration within the c-myc gene, and subsequent expansion of Myc-overexpressing lymphocytes within transformed follicles...
  74. ncbi Immunohistochemical localization of avian leukosis virus subgroup J in tissues from naturally infected chickens
    S Gharaibeh
    Department of Avian Medicine, University of Georgia, Athens 30602, USA
    Avian Dis 45:992-8. 2001
    The tissue tropism of avian leukosis virus (ALV) subgroup J (ALV-J) was investigated in congenitally infected broiler chickens by an immunohistochemistry technique detecting gp85 viral glycoprotein...
  75. ncbi Basophilic intracytoplasmic viral matrix inclusions distributed widely in layer hens affected with avian-leukosis-virus-associated tumours
    Kikuyasu Nakamura
    National Institute of Animal Health Kannondai, Tsukuba, Ibaraki 305 0856 Japan
    Avian Pathol 36:53-8. 2007
    ..MIs in the various tissues were strongly positive for the avian leukosis virus (ALV) antigen...
  76. ncbi Detection and localization of naturally transmitted avian leukosis subgroup J virus in egg-type chickens by in situ PCR hybridization
    N Li
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    J Vet Med A Physiol Pathol Clin Med 54:553-8. 2007
    b>Avian leukosis virus (ALV) subgroup J (ALV-J) is an exogenous ALV and causes myeloid leukosis in meat-type chickens...
  77. ncbi Histopathological characteristics of spindle-cell proliferative disease in broiler chickens and its experimental reproduction in specific pathogen-free chickens
    Shigeaki Takami
    Department of Pathogenic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Japan
    J Vet Med Sci 66:231-5. 2004
    ..Reverse transcriptase-polymerase chain reaction performed using primers specific for subgroup J avian leukosis virus (ALV) produced specific amplifications of subgroup J ALV genes in 4 of 5 field cases examined.
  78. ncbi Multiple infection of chickens and turkeys with avian oncogenic viruses: prevalence and molecular analysis
    I Davidson
    Division of Avian Diseases, Kimron Veterinary Institute, Bet Dagan, Israel
    Acta Virol 43:136-42. 1999
    The avian herpesvirus, Marek's disease virus (MDV) and several retroviruses, reticuloendotheliosis virus (REV), avian leukosis virus (ALV) (chickens) and lymphoproliferative disease virus (turkeys) are oncogenic and immunosuppressive ..
  79. ncbi [Receptors for animal retroviruses]
    Takayuki Miyazawa
    Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Uirusu 59:223-42. 2009
    ..feline leukemia virus subgroups A, B, C, and T, Jaagsiekte sheep retrovirus, enzootic nasal tumor virus, avian leukosis virus subgroups A, B, C, D, E, and J, reticuloendotheliosis virus, RD-114 virus (a feline endogenous ..
  80. ncbi Integration of multiple chicken retroviruses into multiple chicken herpesviruses: herpesviral gD as a common target of integration
    R J Isfort
    CP and RSD HSD, Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239 8707
    Virology 203:125-33. 1994
    Integration of two different avian retroviruses, reticuloendotheliosis virus (REV) and avian leukosis virus (ALV), into the genome of two different avian herpesviruses, the herpesvirus of turkeys (HVT) and Marek's disease virus (MDV), was ..
  81. ncbi Structural requirements for nucleocapsid protein-mediated dimerization of avian leukosis virus RNA
    Moez Ben Ali
    CNRS UMR8113, LBPA, Ecole Normale Superieure de Cachan, 94235, Cachan Cedex, France
    J Mol Biol 372:1082-96. 2007
    The avian leukosis virus (ALV) belongs to the alpha group of retroviruses that are widespread in nature...
  82. pmc Occupational exposure to poultry and prevalence of antibodies against Marek's disease virus and avian leukosis retroviruses
    D Choudat
    Faculté de Médecine Cochin Port Royal, Universite Paris V, France
    Occup Environ Med 53:403-10. 1996
    To compare the prevalence of antibodies against Marek's disease herpes virus (MDV) and against avian leukosis viruses type C (ALV) in groups of workers exposed to poultry and in unexposed groups.
  83. ncbi Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors
    Jingqiong Hu
    Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 18:691-700. 2007
    ..this study we investigated for the first time the ability of ASLV-derived RCAS (replication-competent ALV LTR [avian leukosis virus long terminal repeat] with a splice acceptor) vectors to transduce rhesus macaque hematopoietic ..
  84. pmc Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus
    Joseph G Victoria
    Blood Systems Research Institute, San Francisco, California 94118, USA
    J Virol 84:6033-40. 2010
    ..b>Avian leukosis virus (ALV), previously shown to be noninfectious for humans, was present as RNA in viral particles, while ..
  85. pmc MicroRNA-26a-mediated regulation of interleukin-2 expression in transformed avian lymphocyte lines
    Hongtao Xu
    Avian Oncogenic Virus Group, Avian Infectious Diseases Programme, Institute for Animal Health, Compton, Berkshire, UK RG20 7NN
    Cancer Cell Int 10:15. 2010
    ..Chicken IL-2 can modulate T-cell proliferation and cytotoxicity in vitro and in vivo and dysregulation of IL-2 expression is observed in diseases such as leukaemia...
  86. ncbi Haemangiomas, leiomyosarcoma and myeloma caused by subgroup J avian leukosis virus in a commercial layer flock
    Honglei Sun
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China
    Acta Vet Hung 58:441-51. 2010
    ..The seroprevalence of avian leukosis subgroup J (ALV-J) antibodies was 13...
  87. ncbi Novel avian leukosis virus-related endogenous proviruses from layer chickens: characterization and development of locus-specific assays
    A Smith
    Nova Scotia Agricultural College, Department of Plant and Animal Sciences, Truro, Nova Scotia, B2N 5E3, Canada
    Poult Sci 88:1580-5. 2009
    ..designated ALVE, that reside in the genome of the chicken and that are closely related to exogenous avian leukosis viruses...
  88. pmc VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells
    S M Curristin
    Department of Microbiology and Immunology and Cancer Center, University of Rochester, School of Medicine and Dentistry, New York 14642, USA
    J Virol 71:5972-81. 1997
    The avian leukosis virus (ALV) long terminal repeat (LTR) contains a compact transcription enhancer that is active in many cell types...
  89. pmc Regulation of avian leukosis virus long terminal repeat-enhanced transcription by C/EBP-Rel interactions
    W J Bowers
    Department of Microbiology and Immunology, University of Rochester, New York 14642, USA
    J Virol 70:3051-9. 1996
    The avian leukosis and sarcoma virus long terminal repeat (LTR) enhancers feature directly repeated CCAAT/enhancer element sequences which are also found in many viral and cellular gene enhancers...
  90. pmc a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer
    W J Bowers
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642
    J Virol 66:6578-86. 1992
    b>Avian leukosis virus (ALV) induces bursal lymphoma in chickens after integration of proviral long terminal repeat (LTR) enhancer sequences next to the c-myc proto-oncogene...
  91. ncbi [Sequence analysis for the complete provial genome of endogenous avian leukosis virus strain SD0501]
    Yi Bo Kong
    College of Veterinary Medicine, Shandong Agriculture University, Taian 271018, China
    Bing Du Xue Bao 24:53-8. 2008
    ..5%. However, a low identity was demonstrated among the representative strains of different subgroups, especially, the env - gene showed obvious difference, the corresponding identity was as low as 56.3% - 91.5%...
  92. ncbi Forensic investigation of a 1986 outbreak of osteopetrosis in commercial brown layers reveals a novel avian leukosis virus-related genome
    Taylor Barbosa
    Poultry Diagnostic and Research Center, Department of Population Health, University of Georgia, 953 College Station Road, Athens, GA 30602, USA
    Avian Dis 54:981-9. 2010
    b>Avian leukosis virus (ALV) is known to cause several neoplastic conditions in chickens, such as B-cell lymphomas, myelocytomas, erythroblastosis, and other types of neoplasia including osteopetrosis...
  93. ncbi Oncogenic retroviruses of cattle, chickens and turkeys: potential infectivity and oncogenicity for humans
    E S Johnson
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Med Hypotheses 46:354-6. 1996
    ..The avian leukosis/sarcoma viruses and bovine leukemia virus show similar infectivity/oncogencity in vitro for humans, and the ..
  94. ncbi Proteolytic processing of particle-associated retroviral polyproteins by homologous and heterologous viral proteinases
    J Konvalinka
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Eur J Biochem 228:191-8. 1995
    ..bovine, simian and human retroviruses using polyproteins of human immunodeficiency virus (HIV) type 1 or avian leukosis virus as substrates...
  95. pmc In vitro characterization of a base pairing interaction between the primer binding site and the minimal packaging signal of avian leukosis virus genomic RNA
    Igor Kanevsky
    Unité Mixte de Recherche 8113 du CNRS, LBPA Alembert, Ecole Normale Superieure de Cachan, 94235 Cachan Cedex, France
    Nucleic Acids Res 31:7070-82. 2003
    ..Interestingly, we found that in other retroviruses the PBS sequence can also base pair with a terminal loop of the stem-loops involved in RNA packaging...
  96. ncbi Evidence for virus closely related to avian myeloblastosis-associated virus type 1 in a commercial stock of chickens
    J Lloyd Spencer
    Canadian Food Inspection Agency, Ottawa Laboratory Fallowfield, Animal Diseases Research Institute, 3851 Fallowfield Road, Ottawa, Ontario, Canada K2H 8P9
    Avian Pathol 32:383-90. 2003
    ..polymerase chain reaction assay detected Rous associated virus-1 (RAV-1), a prototype laboratory strain of avian leukosis virus of subgroup A (ALV-A)...
  97. ncbi Inhibition of apoptosis by Marek's disease viruses
    D Ewert
    Wistar Institute, Philadelphia, PA 19104, USA
    Acta Virol 43:133-5. 1999
    ..a herpesvirus, have been shown to augment the development of lymphoid leukosis induced by retroviruses, the avian leukosis virus (ALV) or the reticuloendotheliosis virus...
  98. pmc Functional interaction between transcriptional elements in the long terminal repeat of reticuloendotheliosis virus: cooperative DNA binding of promoter- and enhancer-specific factors
    A Hirano
    Department of Microbiology, University of Washington School of Medicine, Seattle 98195
    Mol Cell Biol 8:5232-44. 1988
    Transcription from reticuloenodotheliosis virus strain T (REV-T), an avian retrovirus unrelated to avian leukosis and sarcoma viruses, is modulated by sequences in at least five functional domains...
  99. pmc Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models
    Zhijun Du
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17396-401. 2006
    We have adapted the avian leukosis virus RCAS (replication-competent avian sarcoma-leukosis virus LTR splice acceptor)-mediated somatic gene transfer technique to introduce oncogenes into mammary cells in mice transgenic for the avian ..
  100. pmc Immune response and resistance to Rous sarcoma virus challenge of chickens immunized with cell-associated glycoproteins provided with a recombinant avian leukosis virus
    Y Chebloune
    Laboratoire de Biologie Cellulaire, Centre National de la Recherche Scientifique UMR106, Universite Claude Bernard Lyon I, Villeurbanne, France
    J Virol 65:5374-80. 1991
    ..Conversely, no immune response and no protection against Rous sarcoma virus A challenge were observed in chickens directly inoculated with cell-free NEA recombinant virus or in sham-inoculated chickens...
  101. pmc Reticuloendotheliosis virus strain T induces miR-155, which targets JARID2 and promotes cell survival
    Mohan T Bolisetty
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Virol 83:12009-17. 2009
    ..of miR-155, termed bic, was first observed to cooperate with myc in chicken B-cell lymphomas induced by avian leukosis proviral integrations...

Research Grants24

  1. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
    ..This experimental system uses a retroviral vector (RCAS) derived from avian leukosis virus and a transgenic mouse line that expresses the retrovirus receptor under control of the Nestin gene ..
  2. Oncogenes and oncogenic microRNAs in chicken tumors
    Karen L Beemon; Fiscal Year: 2012
    ..Recently, activation of TERT by avian leukosis virus (ALV) integration was observed in B-cell lymphomas in chickens...
  3. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2009
    ..Sca-1+ progenitor cells by a knock-in of the reverse tetracycline-responsive transactivator (rtTA) and the avian leukosis virus TVA receptor into the Sca-1 locus...
  4. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 2001
    ..When chickens are infected in the perinatal period with avian leukosis (ALV), a retrovirus that does not contain a known transforming segment, 50-70% of birds in susceptible strains ..
  5. POSSIBLE OF ROLE OF AVIAN RETROVIRUSES IN HUMAN CANCER
    Eric Johnson; Fiscal Year: 2002
    ..studies we have carried out indicate that the genome of tumor cells from poultry workers highly exposed to avian leukosis/sarcoma viruses (ALSV), or with potential for such an exposure, and who died of cancer may carry integrated ..
  6. Technology to Optimize scFvs for Targeting Therapeutics
    MARK FEDERSPIEL; Fiscal Year: 2007
    ..We have recently demonstrated the feasibility of a retrovirus, avian leukosis virus (ALV), as a viral platform for the display of a variety of eukaryotic polypeptides including scFvs, and ..
  7. BIOCHEMISTRY OF RNA TUMOR VIRUS REPLICATION
    RALPH SMITH; Fiscal Year: 1990
    The connection between anemia, immunosuppression, and proliferative disorders caused by avian leukosis viruses will be investigated...
  8. ONCOGENE ACTIVATION IN B AND T LYMPHOCYTES
    Hsing Jien Kung; Fiscal Year: 2000
    ..Avian B-lymphomas are frequently associated with infections by nonacute retroviruses, ALV (avian leukosis virus) and REV (reticuloendotheliosis virus)...
  9. RETROVIRUS-HOST INTERACTIONS
    Harriet Robinson; Fiscal Year: 1992
    A series of in vitro constructed recombinants of endogenous and exogenous avian leukosis viruses (ALVs) will be used in lines of chickens which have been bred for endogenous virus content to study the role of specific ALV sequences in ..
  10. WORKSHOP ON PATHOGENESIS BY NON-ACUTE RETROVIRUSES
    Hung Fan; Fiscal Year: 1992
    ..Viruses to be considered include murine leukemia viruses, avian leukosis virus, feline leukemia virus, murine mammary tumor virus, HTLV-I, bovine leukemia virus, MAIDS virus, and non-..
  11. Retrovirus Entry and Virus Evolution
    MARK FEDERSPIEL; Fiscal Year: 2007
    ..The homologous group of retroviruses, the subgroups A through E (A-E) avian leukosis viruses (ALV), provide a powerful model system to test these hypotheses by supplying highly related viruses ..
  12. AVIAN LEUKOSIS VIRUSES AND CANCER
    Harriet Robinson; Fiscal Year: 1991
    b>Avian leukosis viruses (ALVs) and in vitro constructed recombinants of ALVs will be used to study the roles of viral and host genes in the induction of cancer...
  13. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2005
    ..We will generate a dual Tg mouse model expressing HIV-tat and the avian leukosis virus (ALV)-receptor, TVA, both under the control of the EC-specific TIE2 promoter...
  14. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2004
    ..This proposal is aimed at better understanding this critical first step of viral replication using the avian leukosis virus (ALV)-receptor model system...
  15. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 2003
    ..These studies focus on the avian leukosis virus-B (ALV), whose receptor, TVB, is a functional death receptor in the TNFR-family...
  16. RECOMBINANT PHARMACETICAL PROTEIN PRODUCTION IN EGGS
    Clague Hodgson; Fiscal Year: 1993
    ..The avian leukosis virus replicative element will be combined with a second transcriptional unit consisting of the steroid ..
  17. Cell Type-Specific Gene Delivery in Mammalian Retina
    Vijay Sarthy; Fiscal Year: 2007
    ..The present proposal describes a cell targeting strategy based on the use of the receptor for subgroup-A avian leukosis virus, TVA, to target retroviral vectors carrying genes of interest to a specific cell type in the mouse ..
  18. CHARACTERIZATION OF THE ALV-INDUCED TRANSFORMED FOLLICLE
    ERIC HUMPHRIES; Fiscal Year: 1990
    b>Avian leukosis virus induces a bursal dependent B cell lymphoma in the chicken. A rare histopathological lesion, the transformed follicle, appears in the bursa shortly after infection...
  19. THIRD WORKSHOP ON THE PATHOGENESIS BY NON-ACTE RETROIR
    Philip Tsichlis; Fiscal Year: 1991
    ..Viruses to be considered include the murine leukemia, avian leukosis, feline leukemia, and murine mammary tumor viruses...
  20. AVIAN LEUKOSIS COMPLEX
    BRUCE CALNEK; Fiscal Year: 1990
    ....
  21. Enhancement of the glycosylation machinery of the hen bioreactor.
    ALEX HARVEY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Avian transgenesis via site-directed integration
    ALEX HARVEY; Fiscal Year: 2006
    ..This novel technology will expedite the creation of chickens that can produce Pharmaceuticals, thereby facilitating drug development, enhancing clinical trials and lowering the cost of Pharmaceuticals. ..
  23. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..abstract_text> ..
  24. A flexible somatic and sporadic mouse model for pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2007
    ..Such an advance would benefit public health by reducing the mortality associated with this disease. [unreadable] [unreadable] [unreadable]..