congenic animals

Summary

Summary: Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci. They are used to investigate the contribution of genetic background differences to PHENOTYPE.

Top Publications

  1. Carr L, Habegger K, Spence J, Liu L, Lumeng L, Foroud T. Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats. Behav Genet. 2006;36:285-90 pubmed
    ..These congenic animals will be an invaluable resource for fine mapping the QTL region and for the identification of the gene(s) that ..
  2. Carr L, Kimpel M, Liang T, McClintick J, McCall K, Morse M, et al. Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. Alcohol Clin Exp Res. 2007;31:1089-98 pubmed
    ..This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains...
  3. Moralejo D, Park H, Speros S, MacMurray A, Kwitek A, Jacob H, et al. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun. 2003;21:315-24 pubmed
    ..The congenic F344.lyp rat should prove useful to dissect the mechanisms by which the Ian5 frameshift mutation affects T cell selection, differentiation and maturation without organ-specific autoimmunity...
  4. Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, Holmdahl R. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet. 2003;33:25-32 pubmed
    ..Hence, Ncf1 is associated with a new autoimmune mechanism leading to severe destructive arthritis, notably similar to rheumatoid arthritis in humans...
  5. MacMurray A, Moralejo D, Kwitek A, Rutledge E, Van Yserloo B, Gohlke P, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002;12:1029-39 pubmed
    ..The lymphopenia mutation may thus be useful not only to elucidate Type 1 diabetes, but also in the function of the Ian gene family as a whole...
  6. Bieg S. Differential expression of p95vav in primary lymphoid tissue of BB rats congenic for the lymphopenia gene. Autoimmunity. 1999;30:37-42 pubmed
    ..An increase in the availability of p95vav during the development and activation of thymocytes in Lyp/Lyp BB rats may therefore contribute to the generation of islet autoreactivity, lymphopenia or both...
  7. Hirai H, Zhang P, Dayaram T, Hetherington C, Mizuno S, Imanishi J, et al. C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol. 2006;7:732-9 pubmed
    ..C/EBPbeta inhibited proliferation less severely than did C/EBPalpha. These data suggest a critical function for C/EBPbeta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors...
  8. Angers I, Sancho Shimizu V, Descoteaux A, Gewirtz A, Malo D. Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice. Mamm Genome. 2006;17:385-97 pubmed
    ..MOLF-Ity mice, they exhibit a different phenotype with respect to Tlr5 expression and Tlr5 signaling, supporting the prediction that Tlr5 is not primarily involved in the disease phenotype underlying the Ity3 locus in MOLF/Ei mice...
  9. Tripodi G, Florio M, Ferrandi M, Modica R, Zimdahl H, Hubner N, et al. Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats. Biochem Biophys Res Commun. 2004;324:562-8 pubmed
    ..In contrast, SBPs of Add2 and Add3 congenic strains were not different from those of the correspondent recipient parental strain. The fine mapping of chr14 congenic segment supports the identity of blood pressure QTL with Add1 gene...
  10. Pang J, Boye S, Kumar A, Dinculescu A, Deng W, Li J, et al. AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation. Invest Ophthalmol Vis Sci. 2008;49:4278-83 pubmed publisher
    ..To test AAV-mediated gene therapy in the rd10 mouse, a natural model of recessive RP caused by mutation of the beta-subunit of rod photoreceptor cGMP phosphodiesterase...

Detail Information

Publications62

  1. Carr L, Habegger K, Spence J, Liu L, Lumeng L, Foroud T. Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats. Behav Genet. 2006;36:285-90 pubmed
    ..These congenic animals will be an invaluable resource for fine mapping the QTL region and for the identification of the gene(s) that ..
  2. Carr L, Kimpel M, Liang T, McClintick J, McCall K, Morse M, et al. Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. Alcohol Clin Exp Res. 2007;31:1089-98 pubmed
    ..This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains...
  3. Moralejo D, Park H, Speros S, MacMurray A, Kwitek A, Jacob H, et al. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun. 2003;21:315-24 pubmed
    ..The congenic F344.lyp rat should prove useful to dissect the mechanisms by which the Ian5 frameshift mutation affects T cell selection, differentiation and maturation without organ-specific autoimmunity...
  4. Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, Holmdahl R. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet. 2003;33:25-32 pubmed
    ..Hence, Ncf1 is associated with a new autoimmune mechanism leading to severe destructive arthritis, notably similar to rheumatoid arthritis in humans...
  5. MacMurray A, Moralejo D, Kwitek A, Rutledge E, Van Yserloo B, Gohlke P, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002;12:1029-39 pubmed
    ..The lymphopenia mutation may thus be useful not only to elucidate Type 1 diabetes, but also in the function of the Ian gene family as a whole...
  6. Bieg S. Differential expression of p95vav in primary lymphoid tissue of BB rats congenic for the lymphopenia gene. Autoimmunity. 1999;30:37-42 pubmed
    ..An increase in the availability of p95vav during the development and activation of thymocytes in Lyp/Lyp BB rats may therefore contribute to the generation of islet autoreactivity, lymphopenia or both...
  7. Hirai H, Zhang P, Dayaram T, Hetherington C, Mizuno S, Imanishi J, et al. C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol. 2006;7:732-9 pubmed
    ..C/EBPbeta inhibited proliferation less severely than did C/EBPalpha. These data suggest a critical function for C/EBPbeta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors...
  8. Angers I, Sancho Shimizu V, Descoteaux A, Gewirtz A, Malo D. Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice. Mamm Genome. 2006;17:385-97 pubmed
    ..MOLF-Ity mice, they exhibit a different phenotype with respect to Tlr5 expression and Tlr5 signaling, supporting the prediction that Tlr5 is not primarily involved in the disease phenotype underlying the Ity3 locus in MOLF/Ei mice...
  9. Tripodi G, Florio M, Ferrandi M, Modica R, Zimdahl H, Hubner N, et al. Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats. Biochem Biophys Res Commun. 2004;324:562-8 pubmed
    ..In contrast, SBPs of Add2 and Add3 congenic strains were not different from those of the correspondent recipient parental strain. The fine mapping of chr14 congenic segment supports the identity of blood pressure QTL with Add1 gene...
  10. Pang J, Boye S, Kumar A, Dinculescu A, Deng W, Li J, et al. AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation. Invest Ophthalmol Vis Sci. 2008;49:4278-83 pubmed publisher
    ..To test AAV-mediated gene therapy in the rd10 mouse, a natural model of recessive RP caused by mutation of the beta-subunit of rod photoreceptor cGMP phosphodiesterase...
  11. Bäckdahl L, Ribbhammar U, Lorentzen J. Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains. Arthritis Rheum. 2003;48:551-9 pubmed
    ..We produced congenic strains for these QTLs in order to map and characterize their impact on arthritis development...
  12. Mas M, Cavailles P, Colacios C, Subra J, Lagrange D, Calise M, et al. Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromos. J Immunol. 2004;172:6354-61 pubmed
    ..Further genetic and functional dissections of these loci should provide insights into pathways that lead to Th2-adverse reactions...
  13. Qian Z, Wasowska B, Behrens E, Cangello D, Brody J, Kadkol S, et al. C6 produced by macrophages contributes to cardiac allograft rejection. Am J Pathol. 1999;155:1293-302 pubmed
    ..1U (C6-) donors, C6 levels remained undetectable and PVG.R8 cardiac allografts were not rejected. These results indicate that C6 produced by macrophages can cause significant tissue damage...
  14. Rubattu S, Hubner N, Ganten U, Evangelista A, Stanzione R, Di Angelantonio E, et al. Reciprocal congenic lines for a major stroke QTL on rat chromosome 1. Physiol Genomics. 2006;27:108-13 pubmed
    ..Our results underscore the functional importance of the Chr 1 stroke QTL. Furthermore, they underscore the utility of stroke/congenic lines in dissecting the genetics of stroke...
  15. Howell J, Yoder M, Srour E. Hematopoietic potential of murine skeletal muscle-derived CD45(-)Sca-1(+)c-kit(-) cells. Exp Hematol. 2002;30:915-24 pubmed
    ..Our goal was to determine the identity of neonatal muscle-derived cells that contain hematopoietic potential and to explore the status of CD45 expression on these cells...
  16. Mullick A, Elias M, Picard S, Bourget L, Jovcevski O, Gauthier S, et al. Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. Infect Immun. 2004;72:5868-76 pubmed
    ..albicans, confirming the causative role of C5 deficiency in the dysregulated cytokine response...
  17. Ariyarajah A, Palijan A, Dutil J, Prithiviraj K, Deng Y, Deng A. Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains. J Hypertens. 2004;22:1495-502 pubmed
    ..The current work is to delineate the chromosome interval harboring this QTL by using congenic strains with different chromosome substitutions...
  18. Bilusic M, Moreno C, Barreto N, Tschannen M, Harris E, Porteous W, et al. Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Croat Med J. 2008;49:586-99 pubmed
    ....
  19. Yagil Y, Yagil C. Congenics in the pathway from quantitative trait loci detection to gene identification: is that the way to go?. J Hypertens. 2003;21:2009-11 pubmed
  20. Wang T, Takabatake T, Kobayashi Y, Nabika T. Sympathetic regulation of renal function in stroke-prone spontaneously hypertensive rats congenic for chromosome 1 blood pressure quantitative trait loci. Clin Exp Pharmacol Physiol. 2008;35:1365-70 pubmed publisher
    ..The reciprocal congenic strains are thereby unique models that may help in the search for intermediate phenotypes and empower functional deduction of candidate genes...
  21. Pravenec M, Zidek V, Musilova A, Vorlicek J, Kren V, St Lezin E, et al. Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat. J Hypertens. 2001;19:1061-4 pubmed
    ..The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2...
  22. Barker J, Schuldt A, Lessard M, Jude C, Vogler C, Soper B. Donor cell replacement in mice transplanted in utero is limited by immune-independent mechanisms. Blood Cells Mol Dis. 2003;31:291-7 pubmed
    ..The mechanism limiting initial expansion may differ from that supporting long-term cell retention...
  23. Olofsson P, Holmberg J, Pettersson U, Holmdahl R. Identification and isolation of dominant susceptibility loci for pristane-induced arthritis. J Immunol. 2003;171:407-16 pubmed
    ..These data highlight the usefulness of the statistical power obtained in a backcross of a complex disease like arthritis...
  24. Wiessner J, Garrett M, Roman R, Mandel N. Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains. Am J Physiol Renal Physiol. 2009;297:F301-6 pubmed publisher
    ..These observations establish that BN rat chromosome 2 and 18 harbor genes that contribute to these processes...
  25. Gillett A, Marta M, Jin T, Tuncel J, Leclerc P, Nohra R, et al. TNF production in macrophages is genetically determined and regulates inflammatory disease in rats. J Immunol. 2010;185:442-50 pubmed publisher
    ..Determination of genes and mechanisms involved in this genetically determined TNF regulation will be valuable in understanding disease pathogenesis and aid treatment development...
  26. Drenjancevic Peric I, Weinberg B, Greene A, Lombard J. Restoration of cerebral vascular relaxation in renin congenic rats by introgression of the Dahl R renin gene. Am J Hypertens. 2010;23:243-8 pubmed publisher
    ..SR-(D13N1 and Syt2)/Mcwi) (RGRR) rats maintained on low-salt (0.4% NaCl) diet...
  27. Lagrange D, Fournié G. Generation of congenic and consomic rat strains. Methods Mol Biol. 2010;597:243-66 pubmed publisher
    ..Although their production is lengthy and costly, it only requires a zootechny unit for breeding and tools for genotyping...
  28. Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, et al. Purification and unique properties of mammary epithelial stem cells. Nature. 2006;439:993-7 pubmed
    ..The mammary stem cells are also a rapidly cycling population in the normal adult and have molecular features indicative of a basal position in the mammary epithelium...
  29. Lu S, Carlsen S, Hansson A, Holmdahl R. Immunization of rats with homologous type XI collagen leads to chronic and relapsing arthritis with different genetics and joint pathology than arthritis induced with homologous type II collagen. J Autoimmun. 2002;18:199-211 pubmed
    ..Taken together, C(XI)IA is a chronic relapsing and erosive polyarthritis that is MHC associated, which in fact fulfills the criteria for diagnosis of RA. Thus the C(XI)IA model will be useful as a novel and relevant animal model for RA...
  30. Min B, McHugh R, Sempowski G, Mackall C, Foucras G, Paul W. Neonates support lymphopenia-induced proliferation. Immunity. 2003;18:131-40 pubmed
    ..CD44(bright) CD4 T cells in neonates have a wide repertoire as judged by the distribution of Vbeta expression. Thus, lymphopenia-induced T cell proliferation is a physiologic process that occurs during the early postnatal period...
  31. Sivo Z, Malo B, Dutil J, Deng A. Accelerated congenics for mapping two blood pressure quantitative trait loci on chromosome 10 of Dahl rats. J Hypertens. 2002;20:45-53 pubmed
    ..To localize quantitative trait loci (QTL) in an animal model that is potentially relevant to human hypertension...
  32. Hall F, Li X, Goeb M, Roff S, Hoggatt H, Sora I, et al. Congenic C57BL/6 mu opiate receptor (MOR) knockout mice: baseline and opiate effects. Genes Brain Behav. 2003;2:114-21 pubmed
    ....
  33. Diao J, Winter E, Chen W, Cantin C, Cattral M. Characterization of distinct conventional and plasmacytoid dendritic cell-committed precursors in murine bone marrow. J Immunol. 2004;173:1826-33 pubmed
    ..Both DC precursor populations can give rise to CD8 alpha(+) and CD8 alpha(-) DC subtypes. Our findings indicate that CD11c(+)MHC II(-)B220(+) and CD11c(+)MHC II(-)B220(-) bone marrow cells are distinct DC lineage-restricted precursors...
  34. Gilibert S, Bataillard A, Nussberger J, Sassard J, Kwitek A. Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats. J Hypertens. 2009;27:1186-93 pubmed
    ..Previous genetic mapping identified quantitative trait loci (QTLs) influencing blood pressure (BP) on rat chromosome 13 (RNO13) in several models of hypertension...
  35. Monti J, Zimdahl H, Schulz H, Plehm R, Ganten D, Hubner N. The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10. Hypertension. 2003;41:938-42 pubmed
    ..Thus, Wnk4 is likely not to represent the underlying disease gene for the QTL captured in chromosome 10 congenic animals.
  36. Wandstrat A, Nguyen C, Limaye N, Chan A, Subramanian S, Tian X, et al. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity. 2004;21:769-80 pubmed
    ..While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes...
  37. Meyer B, Bazzi H, Zidek V, Musilova A, Pravenec M, Kurtz T, et al. A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model. Differentiation. 2004;72:541-7 pubmed
    ..Further studies on the skin histology in affected rats demonstrated features consistent with a lanceolate hair mutation, providing further support for the crucial role of desmoglein 4 in hair shaft differentiation...
  38. Shao H, Sinasac D, Burrage L, Hodges C, Supelak P, Palmert M, et al. Analyzing complex traits with congenic strains. Mamm Genome. 2010;21:276-86 pubmed publisher
    ..Sequential analysis rigorously resolved phenotypic heterogeneity among strains in the congenic panels and found QTLs that other methods failed to detect...
  39. Rintisch C, Ameri J, Olofsson P, Luthman H, Holmdahl R. Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats. Proc Natl Acad Sci U S A. 2008;105:14005-10 pubmed publisher
    ..In addition, RF congenic rats had a significantly enhanced immune response toward OVA due to increased OVA-Igk but not OVA-Igl antibodies, suggesting a possible involvement of RF in the regulation of the humoral immune response...
  40. Klaff L, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, et al. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mamm Genome. 1999;10:883-7 pubmed
    ..008). In conclusion, the development of Type 1 diabetes in the congenic DR(lyp/lyp) rat is controlled by at least three genes: lymphopenia, MHC, and a third factor that may play a role in metabolism and body weight regulation...
  41. Yao H, Cui Z, Masuda J, Nabika T. Congenic removal of a QTL for blood pressure attenuates infarct size produced by middle cerebral artery occlusion in hypertensive rats. Physiol Genomics. 2007;30:69-73 pubmed
    ..We demonstrated for the first time that the congenic strategy is useful to investigate the effects of genetic hypertension on focal ischemia or stroke...
  42. Nassar I, Schulz A, Bernardy C, Garrelds I, Plehm R, Huber M, et al. A twofold genetic increase of ACE expression has no effect on the development of spontaneous hypertension. Am J Hypertens. 2008;21:200-5 pubmed publisher
    ..e., the Ace allele of the normotensive Wistar-Kyoto (WKY) rat, in the hypertensive background of stroke-prone spontaneously hypertensive (SHRSP) rats...
  43. Dominguez C, Li L, Lidman O, Olsson T, Wiesenfeld Hallin Z, Piehl F, et al. Both MHC and non-MHC genes regulate development of experimental neuropathic pain in rats. Neurosci Lett. 2008;442:284-6 pubmed publisher
    ..The results demonstrate that both MHC and non-MHC genes influence experimental neuropathic pain in rats and also suggest that allelic variation contained in the RT1(av1) haplotype on the PVG background protects against neuropathic pain...
  44. Charron S, Duong C, Ménard A, Roy J, Eliopoulos V, Lambert R, et al. Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension. Hypertension. 2005;46:1300-8 pubmed
    ..The epistatic and additive interactions uncovered in the animal model will help elucidate similar interactions playing a role in human essential hypertension...
  45. Kloting N, Kloting I. Congenic mapping of type 1 diabetes--protective gene(s) in an interval of 4 Mb on rat chromosome 6q32. Biochem Biophys Res Commun. 2004;323:388-94 pubmed
    ..6S and SHR compared with BB/OK favouring Yy1 and Pref-1 as candidate genes. All other genes were differently expressed according to gender and strain...
  46. Potenza M, Brodkin E, Joe B, Luo X, Remmers E, Wilder R, et al. Genomic regions controlling corticosterone levels in rats. Biol Psychiatry. 2004;55:634-41 pubmed
    ..The identification of genetic factors controlling stress-responsiveness should advance the understanding of susceptibility to psychiatric illness...
  47. Haag J, Shepel L, Kolman B, Monson D, Benton M, Watts K, et al. Congenic rats reveal three independent Copenhagen alleles within the Mcs1 quantitative trait locus that confer resistance to mammary cancer. Cancer Res. 2003;63:5808-12 pubmed
    ..The identification of these independent loci within the Mcs1 COP allele provide a model of the genetic complexity of cancer...
  48. Liu Z, Deng G, Foster S, Tarkowski A. Staphylococcal peptidoglycans induce arthritis. Arthritis Res. 2001;3:375-80 pubmed
    ..Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus...
  49. Roberts C, Kean L, Archer D, Balkan C, Hsu L. Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantation. Ann N Y Acad Sci. 2005;1054:423-8 pubmed
    ..Murine and human transplant results were compared with a math model for survival advantage of donor peripheral blood cells produced by steady-state chimeric marrow...
  50. Saad Y, Yerga Woolwine S, Saikumar J, Farms P, Manickavasagam E, Toland E, et al. Congenic interval mapping of RNO10 reveals a complex cluster of closely-linked genetic determinants of blood pressure. Hypertension. 2007;50:891-8 pubmed
    ..Because all of these genetic elements are located within a 1.06-Mb region of RNO10, our study has revealed a remarkable insight into a genomic module comprising very closely-linked, opposing genetic determinants of BP...
  51. Masui N, Nishikawa T, Takagi Y, Kimura H, Mori M, Yokose S, et al. Establishment of a set of combined immunodeficient DA/Slc-Foxn1(rnu) Lyst(bg) congenic rat strains. Exp Anim. 2004;53:399-407 pubmed
    ....
  52. Ruhlen R, Willbrand D, Besch Williford C, Ma L, Shull J, Sauter E. Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model. Breast Cancer Res Treat. 2009;117:517-24 pubmed publisher
    ..ERalpha and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers...
  53. Bunting K, Bradley H, Hawley T, Moriggl R, Sorrentino B, Ihle J. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood. 2002;99:479-87 pubmed
    ..These results demonstrate that a significant proportion of the growth factor signals required for multilineage reconstitution potential of HSCs is STAT5 dependent...
  54. Clark L, Greenbaum C, Jiang J, Lernmark A, Ochs H. The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats. FEMS Immunol Med Microbiol. 2002;32:205-9 pubmed
    ..006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region...
  55. Tomozawa H, Nishio A, Okuhara Y, Higuchi K, Matsumoto K, Mori M. BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. Exp Anim. 2010;59:469-78 pubmed
    ..The newly established BN.MES-Cyba(mes) congenic rat strain, together with the original MES strain, will provide useful models for elucidating the molecular genetic mechanisms involved in the development and trafficking of eosinophils...
  56. Graca L, Daley S, Fairchild P, Cobbold S, Waldmann H. Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning. BMC Immunol. 2006;7:9 pubmed
    ..A major challenge in the application of marrow transplantation as a route to immunological tolerance of a transplanted organ is to achieve hematopoietic stem cell (HSC) engraftment with minimal myelosuppressive treatments...
  57. Dutil J, Deng A. Mapping a blood pressure quantitative trait locus to a 5.7-cM region in Dahl salt-sensitive rats. Mamm Genome. 2001;12:362-5 pubmed
    ..This region does not seem to contain any candidate genes well known for the BP control. Thus, the final identification of the QTL will most likely lead to the discovery of a brand new gene for the BP regulation...
  58. Rosengren A, Jokubka R, Tojjar D, Granhall C, Hansson O, Li D, et al. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science. 2010;327:217-20 pubmed publisher
    ..Human pancreatic islets from risk allele carriers exhibited reduced granule docking and secreted less insulin in response to glucose; both effects were counteracted by pharmacological alpha(2A)AR antagonists...
  59. Varnum Finney B, Brashem Stein C, Bernstein I. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood. 2003;101:1784-9 pubmed
    ....
  60. Tanomura H, Taniguchi Y, Muramatsu Y, Kose H, Miyake T, Matsumoto K, et al. A congenic strain (F344.OLETF-Imfm) displays the existence of intramuscular fat accumulation QTL on rat chromosome 1. Exp Anim. 2003;52:303-8 pubmed
    ..The F344.OLETF-Imfm congenic strain might provide a refined tool for the analysis of the gene causing intramuscular fat accumulation...
  61. Pendergrass K, Averill D, Ferrario C, Diz D, Chappell M. Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2. Lewis rat. Am J Physiol Renal Physiol. 2006;290:F1497-506 pubmed
    ..Lewis. The downregulation of AT1 sites in the mRen2. Lewis rats may reflect a compensatory response to dampen the elevated levels of intrarenal ANG II...
  62. Kose H, Moralejo D, Ogino T, Mizuno A, Yamada T, Matsumoto K. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Mamm Genome. 2002;13:558-62 pubmed
    ..Here we generated a series of congenic animals by individually introgressing all 11 OLETF-derived NIDDM loci into a normoglycemic F344 background...