pancreatic juice

Summary

Summary: The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.

Top Publications

  1. Hirota M, Kamekawa K, Tashima T, Mizumoto M, Ohara C, Beppu T, et al. Percutaneous embolization of the distal pancreatic duct to treat intractable pancreatic juice fistula. Pancreas. 2001;22:214-6 pubmed
    ..In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region...
  2. De Caro A, Bonicel J, Rouimi P, De Caro J, Sarles H, Rovery M. Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice. Eur J Biochem. 1987;168:201-7 pubmed
    ..The protein studied was the lowest-Mr form prepared from human pancreatic juice (PSP S1). The N-terminal sequence up to residue 65 had already been determined...
  3. Hashimoto Y, Murakami Y, Uemura K, Hayashidani Y, Sudo T, Ohge H, et al. Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer. Surgery. 2008;143:113-25 pubmed
    ..of immunohistochemistry (IHC) for the diagnosis of pancreatic cancer, hTERT expression and telomerase activity were assayed in pancreatic tissues, ex vivo brushing, and pancreatic juice samples with various pancreatic diseases.
  4. Kapica M, Zabielska M, Puzio I, Jankowska A, Kato I, Kuwahara A, et al. Obestatin stimulates the secretion of pancreatic juice enzymes through a vagal pathway in anaesthetized rats - preliminary results. J Physiol Pharmacol. 2007;58 Suppl 3:123-30 pubmed
    ..The aim of the present study was to determine the influence of exogenous obestatin on the secretion of pancreatic juice. In anesthetized male Wistar rats the external jugular vein was catheterized, and the common biliary-..
  5. Grote T, Logsdon C. Progress on molecular markers of pancreatic cancer. Curr Opin Gastroenterol. 2007;23:508-14 pubmed
    ..To describe advances in the development of biomarkers for pancreatic cancer over the past year...
  6. Ohuchida K, Mizumoto K, Yu J, Yamaguchi H, Konomi H, Nagai E, et al. S100A6 is increased in a stepwise manner during pancreatic carcinogenesis: clinical value of expression analysis in 98 pancreatic juice samples. Cancer Epidemiol Biomarkers Prev. 2007;16:649-54 pubmed
    ..did quantitative real-time reverse transcription-PCR to measure mRNA expression in microdissected cells and pancreatic juice samples...
  7. Paluszkiewicz P, Zgrajka W, Saran T, Schabowski J, Piedra J, Fedkiv O, et al. High concentration of kynurenic acid in bile and pancreatic juice. Amino Acids. 2009;37:637-41 pubmed publisher
    ..The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography...
  8. Shirai Y, Sogawa K, Yamaguchi T, Sudo K, Nakagawa A, Sakai Y, et al. Protein profiling in pancreatic juice for detection of intraductal papillary mucinous neoplasm of the pancreas. Hepatogastroenterology. 2008;55:1824-9 pubmed
    ..Recent advances in proteomic analysis are remarkable; therefore we explored novel biomarkers for IPMN using Surface-Enhanced Laser Desorption and Ionization (SELDI) Mass Spectrometry...
  9. Watanabe H, Okada G, Ohtsubo K, Yamaguchi Y, Mouri H, Motoo Y, et al. Expression of mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis. Pancreas. 2005;30:349-54 pubmed
    ..We evaluated mesothelin mRNA expression in pure pancreatic juice (PPJ) obtained from patients with PCa, chronic pancreatitis (CP), and intraductal papillary mucinous neoplasm ..
  10. Dalbec K, Max Schmidt C, Wade T, Wang S, Swartz Basile D, Pitt H, et al. Adipokines and cytokines in human pancreatic juice: unraveling the local pancreatic inflammatory milieu. Dig Dis Sci. 2010;55:2108-12 pubmed publisher
    ..b>Pancreatic juice analysis may provide a good means to evaluate the local pancreatic inflammatory milieu...

Detail Information

Publications62

  1. Hirota M, Kamekawa K, Tashima T, Mizumoto M, Ohara C, Beppu T, et al. Percutaneous embolization of the distal pancreatic duct to treat intractable pancreatic juice fistula. Pancreas. 2001;22:214-6 pubmed
    ..In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region...
  2. De Caro A, Bonicel J, Rouimi P, De Caro J, Sarles H, Rovery M. Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice. Eur J Biochem. 1987;168:201-7 pubmed
    ..The protein studied was the lowest-Mr form prepared from human pancreatic juice (PSP S1). The N-terminal sequence up to residue 65 had already been determined...
  3. Hashimoto Y, Murakami Y, Uemura K, Hayashidani Y, Sudo T, Ohge H, et al. Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer. Surgery. 2008;143:113-25 pubmed
    ..of immunohistochemistry (IHC) for the diagnosis of pancreatic cancer, hTERT expression and telomerase activity were assayed in pancreatic tissues, ex vivo brushing, and pancreatic juice samples with various pancreatic diseases.
  4. Kapica M, Zabielska M, Puzio I, Jankowska A, Kato I, Kuwahara A, et al. Obestatin stimulates the secretion of pancreatic juice enzymes through a vagal pathway in anaesthetized rats - preliminary results. J Physiol Pharmacol. 2007;58 Suppl 3:123-30 pubmed
    ..The aim of the present study was to determine the influence of exogenous obestatin on the secretion of pancreatic juice. In anesthetized male Wistar rats the external jugular vein was catheterized, and the common biliary-..
  5. Grote T, Logsdon C. Progress on molecular markers of pancreatic cancer. Curr Opin Gastroenterol. 2007;23:508-14 pubmed
    ..To describe advances in the development of biomarkers for pancreatic cancer over the past year...
  6. Ohuchida K, Mizumoto K, Yu J, Yamaguchi H, Konomi H, Nagai E, et al. S100A6 is increased in a stepwise manner during pancreatic carcinogenesis: clinical value of expression analysis in 98 pancreatic juice samples. Cancer Epidemiol Biomarkers Prev. 2007;16:649-54 pubmed
    ..did quantitative real-time reverse transcription-PCR to measure mRNA expression in microdissected cells and pancreatic juice samples...
  7. Paluszkiewicz P, Zgrajka W, Saran T, Schabowski J, Piedra J, Fedkiv O, et al. High concentration of kynurenic acid in bile and pancreatic juice. Amino Acids. 2009;37:637-41 pubmed publisher
    ..The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography...
  8. Shirai Y, Sogawa K, Yamaguchi T, Sudo K, Nakagawa A, Sakai Y, et al. Protein profiling in pancreatic juice for detection of intraductal papillary mucinous neoplasm of the pancreas. Hepatogastroenterology. 2008;55:1824-9 pubmed
    ..Recent advances in proteomic analysis are remarkable; therefore we explored novel biomarkers for IPMN using Surface-Enhanced Laser Desorption and Ionization (SELDI) Mass Spectrometry...
  9. Watanabe H, Okada G, Ohtsubo K, Yamaguchi Y, Mouri H, Motoo Y, et al. Expression of mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis. Pancreas. 2005;30:349-54 pubmed
    ..We evaluated mesothelin mRNA expression in pure pancreatic juice (PPJ) obtained from patients with PCa, chronic pancreatitis (CP), and intraductal papillary mucinous neoplasm ..
  10. Dalbec K, Max Schmidt C, Wade T, Wang S, Swartz Basile D, Pitt H, et al. Adipokines and cytokines in human pancreatic juice: unraveling the local pancreatic inflammatory milieu. Dig Dis Sci. 2010;55:2108-12 pubmed publisher
    ..b>Pancreatic juice analysis may provide a good means to evaluate the local pancreatic inflammatory milieu...
  11. Kruszewska D, Ljungh A, Hynes S, Pierzynowski S. Effect of the antibacterial activity of pig pancreatic juice on human multiresistant bacteria. Pancreas. 2004;28:191-9 pubmed
    ..The role of the exocrine pancreas in regulating gut microflora colonization is unclear. The main objective in the current study was to assess the effect of pancreatic fluid on the growth of pathogenic bacteria and fungi...
  12. Yoshida K, Ueno S, Iwao T, Yamasaki S, Tsuchida A, Ohmine K, et al. Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma. Cancer Sci. 2003;94:263-70 pubmed
    ..effect, the pancreatic ductal epithelial cells were purified by MUC1-based affinity chromatography from pancreatic juice isolated from both healthy individuals and PDC patients...
  13. Motoo Y, Watanabe H, Yamaguchi Y, Xie M, Mouri H, Ohtsubo K, et al. Pancreatitis-associated protein levels in pancreatic juice from patients with pancreatic diseases. Pancreatology. 2001;1:43-7 pubmed
    ..Although PAP was originally identified in pancreatic juice, there has been no clinical report on PAP levels in pancreatic juice...
  14. Fischer C, Büthe J, Nollau P, Hollerbach S, Schulmann K, Schmiegel W, et al. Enrichment of mutant KRAS alleles in pancreatic juice by subtractive iterative polymerase chain reaction. Lab Invest. 2001;81:827-31 pubmed
    ..To prove the feasibility of siPCR, pancreatic juice samples were analyzed for KRAS mutations...
  15. Makawita S, Smith C, Batruch I, Zheng Y, Ruckert F, Grutzmann R, et al. Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers. Mol Cell Proteomics. 2011;10:M111.008599 pubmed publisher
    ..The present study details the combined mining of pancreatic cancer-related cell line conditioned media and pancreatic juice for identification of putative diagnostic leads...
  16. Hashimoto N, Ohyanagi H. Pancreatic juice output and amylase level in the drainage fluid after pancreatoduodenectomy in relation to leakage. Hepatogastroenterology. 2002;49:553-5 pubmed
    ..The objective of this study was to clarify the relationship between the consistency of the pancreas and pancreatic anastomotic leakage after pancreatectomy...
  17. Ohtsubo K, Watanabe H, Okada G, Tsuchiyama T, Mouri H, Yamaguchi Y, et al. A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice. JOP. 2008;9:37-45 pubmed
    ..There have been some cases of an ambiguous diagnosis although care was taken to differentiate between alcoholic mass-forming pancreatitis, focal type autoimmune pancreatitis and pancreatic cancer...
  18. Zhou L, Lu Z, Yang A, Deng R, Mai C, Sang X, et al. Comparative proteomic analysis of human pancreatic juice: methodological study. Proteomics. 2007;7:1345-55 pubmed
    ..Here, we optimized and applied a proteome analysis of human pancreatic juice to identify biomarkers for pancreatic cancer...
  19. Okai T, Watanabe H, Yamaguchi Y, Mouri I, Motoo Y, Sawabu N. EUS and K-ras analysis of pure pancreatic juice collected via a duodenoscope after secretin stimulation for diagnosis of pancreatic mass lesion: a prospective study. Gastrointest Endosc. 1999;50:797-803 pubmed
    ..This prospective study assessed the utility of a combination of endoscopic ultrasound (EUS) and genetic analysis of pure pancreatic juice in the diagnosis of pancreatic mass lesions.
  20. Ohuchida K, Mizumoto K, Ohhashi S, Yamaguchi H, Konomi H, Nagai E, et al. Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice. Int J Cancer. 2007;120:1634-40 pubmed
    ..from 19 sections, PanIN from 6 sections, and pancreatitis-affected epithelial cells from 14 sections), and pancreatic juice (16 from cancer, 28 from IPMN, and 17 from pancreatitis)...
  21. Tian M, Cui Y, Song G, Zong M, Zhou X, Chen Y, et al. Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer. 2008;8:241 pubmed publisher
    ..b>Pancreatic juice is an ideal specimen for PDAC biomarkers discovery, because it is an exceptionally rich source of proteins ..
  22. Jiang P, Watanabe H, Okada G, Ohtsubo K, Mouri H, Tsuchiyama T, et al. Diagnostic utility of aberrant methylation of tissue factor pathway inhibitor 2 in pure pancreatic juice for pancreatic carcinoma. Cancer Sci. 2006;97:1267-73 pubmed
    ..We analyzed the aberrant methylation of TFPI-2 in the pure pancreatic juice (PPJ) aspirated endoscopically from patients with various pancreatic diseases...
  23. Naito Y, Okabe Y, Nagayama M, Nishinakagawa T, Taira T, Kawahara A, et al. Accuracy of differential diagnosis for pancreatic cancer is improved in the combination of RCAS1 and CEA measurements and cytology in pancreatic juice. Med Mol Morphol. 2011;44:86-92 pubmed publisher
    ..e., measurements of RCAS1 and CEA levels in pancreatic juice and pancreatic juice cytology...
  24. Matsubayashi H, Canto M, Sato N, Klein A, Abe T, Yamashita K, et al. DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease. Cancer Res. 2006;66:1208-17 pubmed
    ..Methylation analysis was done on pancreatic juice collected endoscopically or surgically from 155 individuals with suspected pancreatic disease: 56 patients ..
  25. Jankowska A, Wrzesinski M, Laubitz D, Kazimierczak W, Skrzypek H, Bardowski J, et al. Intestinal MMC-related electric fields and pancreatic juice control the adhesion of Gram-positive and Gram-negative bacteria to the gut epithelium--in vitro study. J Physiol Pharmacol. 2008;59:795-810 pubmed
    ..Two later strains adhered even less in the presence of EF. The same tendency was found in the presence of pancreatic juice in a cell medium...
  26. Park J, Kim S, Chung J, Bang S, Park S, Paik Y, et al. Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer. J Cancer Res Clin Oncol. 2011;137:1229-38 pubmed publisher
    Protein profiles of endoscopically collected pancreatic juice from normal, chronic pancreatitis patients and pancreatic cancer patients were compared to identify diagnostic biomarkers of pancreatic cancer.
  27. Nakashima A, Murakami Y, Uemura K, Hayashidani Y, Sudo T, Hashimoto Y, et al. Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy. Pancreas. 2009;38:527-33 pubmed publisher
    ..In the present study, we did a large-scale analysis of 115 preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunohistochemistry for ..
  28. Lv S, Gao J, Zhu F, Li Z, Gong Y, Xu G, et al. Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. Diagn Cytopathol. 2011;39:875-81 pubmed publisher
    Analyses of pancreatic juice by proteomics have identified many proteins that are overabundant in pancreatic cancer (PC) juice. The mechanism by which secretion of these proteins occur remains unclear...
  29. Wang Y, Yamaguchi Y, Watanabe H, Ohtsubo K, Motoo Y, Sawabu N. Detection of p53 gene mutations in the supernatant of pancreatic juice and plasma from patients with pancreatic carcinomas. Pancreas. 2004;28:13-9 pubmed
    The sensitivity of pure pancreatic juice (PPJ) cytology for the diagnosis of pancreatic carcinoma (PCa) is still low. The usefulness of genetic analyses of PPJ seems to be limited because of insufficient sensitivity or false positivity...
  30. Prokopczyk B, Hoffmann D, Bologna M, Cunningham A, Trushin N, Akerkar S, et al. Identification of tobacco-derived compounds in human pancreatic juice. Chem Res Toxicol. 2002;15:677-85 pubmed
    ..was conducted to determine whether cotinine and tobacco-specific nitrosamines (TSNA) are present in human pancreatic juice. Smoking status was assessed by the determination of levels of urinary cotinine and was further supported by ..
  31. Habbe N, Koorstra J, Mendell J, Offerhaus G, Ryu J, Feldmann G, et al. MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol Ther. 2009;8:340-6 pubmed
    ..Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented...
  32. Oliveira Cunha M, Byers R, Siriwardena A. Poly(adenylic acid) complementary DNA real-time polymerase chain reaction in pancreatic ductal juice in patients undergoing pancreaticoduodenectomy. Pancreas. 2010;39:171-4 pubmed publisher
    There is a need to develop methods of early diagnosis for pancreatic cancer. Pancreatic juice is easily collected by endoscopic retrograde cholangiopancreatography and may facilitate diagnosis using molecular markers...
  33. Mori Y, Ohtsuka T, Tsutsumi K, Yasui T, Sadakari Y, Ueda J, et al. Multifocal pancreatic ductal adenocarcinomas concomitant with intraductal papillary mucinous neoplasms of the pancreas detected by intraoperative pancreatic juice cytology. A case report. JOP. 2010;11:389-92 pubmed
    ..Recently, invasive ductal carcinoma of the pancreas concomitant with IPMNs has been the focus of attention...
  34. Uehara H, Nakaizumi A, Iishi H, Takenaka A, Eguchi H, Ohigashi H, et al. In situ telomerase activity in pancreatic juice may discriminate pancreatic cancer from other pancreatic diseases. Pancreas. 2008;36:236-40 pubmed publisher
    Detection of telomerase activity in pancreatic juice samples by telomeric repeat amplification protocol (TRAP) has been shown to be a useful diagnostic test for pancreatic cancer...
  35. Wang J, Ma C, Liao Z, Tian B, Lu J. Study on chronic pancreatitis and pancreatic cancer using MRS and pancreatic juice samples. World J Gastroenterol. 2011;17:2126-30 pubmed publisher
    ..To investigate the markers of pancreatic diseases and provide basic data and experimental methods for the diagnosis of pancreatic diseases...
  36. Kanda M, Knight S, Topazian M, Syngal S, Farrell J, Lee J, et al. Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts. Gut. 2013;62:1024-33 pubmed publisher
    ..Better approaches are needed to characterise these lesions. In this study we evaluated the utility of detecting mutant DNA in secretin-stimulated pancreatic juice.
  37. Yao F, Sun M, Dong M, Jing F, Chen B, Xu H, et al. NPTX2 hypermethylation in pure pancreatic juice predicts pancreatic neoplasms. Am J Med Sci. 2013;346:175-80 pubmed publisher
    ..the authors investigated the utility of methylated NPTX2 as a diagnostic marker for pancreatic cancer in pure pancreatic juice samples of patients with benign and malignant pancreatic diseases, including pancreatic cancer, intraductal ..
  38. Hara T, Ikebe D, Odaka A, Sudo K, Nakamura K, Yamamoto H, et al. Preoperative histological subtype classification of intraductal papillary mucinous neoplasms (IPMN) by pancreatic juice cytology with MUC stain. Ann Surg. 2013;257:1103-11 pubmed publisher
    To prospectively evaluate the diagnostic value of preoperative histological subtyping of intraductal papillary mucinous neoplasms (IPMNs) by pancreatic juice cytology (PJC) with mucin (MUC) stain.
  39. Muftuoglu M, Ozkan E, Saglam A. Effect of human pancreatic juice and bile on the tensile strength of suture materials. Am J Surg. 2004;188:200-3 pubmed
    Several suture materials are used for pancreatojejunal anastomosis. In this study, we tested the durability of these suture materials in human pancreatic juice and bile.
  40. Bosc Bierne I, Rathelot J, Bechis G, Delori P, Sarda L. Evidence for the existence of procolipase in chicken pancreas and pancreatic juice. Biochimie. 1984;66:413-6 pubmed
    ..those of the precursor form of colipase (procolipase) previously isolated from porcine and equine pancreas or pancreatic juice. Further evidence for the existence of procolipase was obtained from kinetic studies of the hydrolysis of the ..
  41. Lombardo D, Guy O. Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters. Biochim Biophys Acta. 1980;611:147-55 pubmed
    ..The other site, unspecific towards bile salts hydroxylation would be located at the active center and would be implicated in substrate recognition...
  42. De Caro J, Carriere F, Barboni P, Giller T, Verger R, De caro A. Pancreatic lipase-related protein 1 (PLRP1) is present in the pancreatic juice of several species. Biochim Biophys Acta. 1998;1387:331-41 pubmed
    ..It was established for the first time that this protein is secreted in variable amounts by the adult exocrine pancreas of several species...
  43. Seki K, Suda T, Aoyagi Y, Sugawara S, Natsui M, Motoyama H, et al. Diagnosis of pancreatic adenocarcinoma by detection of human telomerase reverse transcriptase messenger RNA in pancreatic juice with sample qualification. Clin Cancer Res. 2001;7:1976-81 pubmed
    We evaluated the diagnostic efficacy of detection of human telomerase reverse transcriptase (hTERT) message, a catalytic domain of human telomerase, in endoscopic retrograde pancreatography (ERP)-derived pancreatic juice.
  44. Tsukuda H, Matsumura Y, Inoue T, Kobayashi Y, Ookawa K, Aoki T, et al. Diagnostic application of CD44 variant expression in pancreatic juice for detection of pancreatic neoplasm. Anticancer Res. 2001;21:2175-83 pubmed
    ..We tried to investigate CD44v expression in pancreatic juice from patients who underwent endoscopic retrograde pancreatography...
  45. Caronna R, Loretta D, Campedelli P, Catinelli S, Nofroni I, Sibio S, et al. Gabexate mesilate (FOY) inhibition of amylase and phospholipase A(2) activity in sow pancreatic juice. J Invest Surg. 2003;16:345-51 pubmed
    ..this study in sows to investigate the enzyme inhibitory action of gabexate mesylate (GM) directly in the pancreatic juice. We studied 16 sows, each weighing about 130 kg...
  46. Goggins M. Identifying molecular markers for the early detection of pancreatic neoplasia. Semin Oncol. 2007;34:303-10 pubmed
    ..As we continue to characterize the genetic, epigenetic, and proteomics alterations that occur in pancreatic cancers and their percursors, better diagnostic markers of pancreatic cancer are expected to follow...
  47. Grønborg M, Bunkenborg J, Kristiansen T, Jensen O, Yeo C, Hruban R, et al. Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res. 2004;3:1042-55 pubmed
    ..In this study, we carried out a comprehensive characterization of the "pancreatic juice proteome" in patients with pancreatic adenocarcinoma...
  48. Caronna R, Diana L, Nofroni I, Sibio S, Catinelli S, Sammartino P, et al. Effects of gabexate mesilate (FOY) on amylase and phospholipase A2 in human serum and pancreatic juice. Dig Dis Sci. 2005;50:868-73 pubmed
    ..We designed this study to investigate the enzyme inhibitory action of GM in the serum and directly in the pancreatic juice. We observed 16 cases with postoperative pancreatic drainage...
  49. Ohuchida K, Mizumoto K, Yamada D, Fujii K, Ishikawa N, Konomi H, et al. Quantitative analysis of MUC1 and MUC5AC mRNA in pancreatic juice for preoperative diagnosis of pancreatic cancer. Int J Cancer. 2006;118:405-11 pubmed
    b>Pancreatic juice is a promising type of diagnostic sample for pancreatic cancer, and members of the mucin (MUC) family are diagnostic candidates...
  50. Ohuchida K, Mizumoto K, Fujita H, Yamaguchi H, Konomi H, Nagai E, et al. Sonic hedgehog is an early developmental marker of intraductal papillary mucinous neoplasms: clinical implications of mRNA levels in pancreatic juice. J Pathol. 2006;210:42-8 pubmed
    ..008). Pancreatic juice analyses (20 samples from pancreatic cancers, 31 samples from IPMNs, and 27 samples from chronic pancreatitis)..
  51. Ohtsubo K, Watanabe H, Yao F, Okada G, Mouri H, Yamaguchi Y, et al. Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma. J Gastroenterol. 2006;41:791-7 pubmed
    ..We analyzed ppENK hypermethylation in pure pancreatic juice (PPJ) in patients with PCa, intraductal papillary mucinous neoplasms (IPMN), and chronic pancreatitis (CP), ..
  52. Tomlinson C, Korc M. Squeezing data from pancreatic juice. Cancer Biol Ther. 2006;5:1390-1 pubmed
  53. Ohuchida K, Mizumoto K, Ogura Y, Ishikawa N, Nagai E, Yamaguchi K, et al. Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer. Clin Cancer Res. 2005;11:2285-92 pubmed
    ..we measured telomerase activity and hTERT expression in pancreatic cancer cell lines, pancreatic tissues, and pancreatic juice samples from patients with different pancreatic diseases...
  54. Whitcomb D, Ermentrout G. A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice. Pancreas. 2004;29:e30-40 pubmed
    ..To develop a simple, physiologically based mathematical model of pancreatic duct cell secretion using experimentally derived parameters that generates pancreatic fluid bicarbonate concentrations of >140 mM after CFTR activation...
  55. Chen R, Pan S, Duan X, Nelson B, Sahota R, de Rham S, et al. Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia. Mol Cancer. 2010;9:149 pubmed publisher
    ..We applied quantitative proteomics to identify aberrantly elevated proteins in pancreatic juice samples derived from patients with PanIN3.
  56. Sadakari Y, Ohtsuka T, Ohuchida K, Tsutsumi K, Takahata S, Nakamura M, et al. MicroRNA expression analyses in preoperative pancreatic juice samples of pancreatic ductal adenocarcinoma. JOP. 2010;11:587-92 pubmed
    Cytological assessment of pancreatic juice is commonly used to diagnose pancreatic ductal adenocarcinoma; however, the sensitivity of cytological assessment has been reported to be low...
  57. Kamisawa T, Takuma K, Tabata T, Egawa N, Yamaguchi T. Long-term follow-up of chronic pancreatitis patients with K-ras mutation in the pancreatic juice. Hepatogastroenterology. 2011;58:174-6 pubmed
    ..This study aimed to identify a high risk group for developing pancreatic cancer associated with chronic pancreatitis, particularly the presence of K-ras mutations in the pancreatic juice.
  58. Rosty C, Christa L, Kuzdzal S, Baldwin W, Zahurak M, Carnot F, et al. Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res. 2002;62:1868-75 pubmed
    ..ProteinChip technology (Ciphergen Biosystems, Fremont, CA) to screen for differentially expressed proteins in pancreatic juice. Pancreatic juice samples obtained from patients undergoing pancreatectomy for pancreatic adenocarcinoma were ..
  59. Ha A, Watanabe H, Yamaguchi Y, Ohtsubo K, Wang Y, Motoo Y, et al. Usefulness of supernatant of pancreatic juice for genetic analysis of K-ras in diagnosis of pancreatic carcinoma. Pancreas. 2001;23:356-63 pubmed
    To ascertain whether analysis of K-ras mutations at codon 12 (KRM) in the supernatant of pure pancreatic juice (PPJ) is more useful for the diagnosis of pancreatic carcinoma (PCa) than that in sediment, the authors analyzed KRM in DNA ..
  60. Rogers C, Fukushima N, Sato N, Shi C, Prasad N, Hustinx S, et al. Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biol Ther. 2006;5:1383-9 pubmed
    ..We hypothesized that gene expression alterations indicative of pancreatic cancer can be detected by profiling the RNA of pancreatic juice.
  61. Kanda M, Sadakari Y, Borges M, Topazian M, Farrell J, Syngal S, et al. Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia. Clin Gastroenterol Hepatol. 2013;11:719-30.e5 pubmed publisher
    ..We investigated whether mutant TP53 can be detected in duodenal samples of secretin-stimulated pancreatic juice, and whether this assay can be used to screen for high-grade dysplasia and invasive pancreatic cancer.
  62. Samuel I. Bile and pancreatic juice exclusion activates acinar stress kinases and exacerbates gallstone pancreatitis. Surgery. 2008;143:434-40 pubmed publisher
    Bile and pancreatic juice exclusion from gut activates acinar stress kinases and exacerbates gallstone pancreatitis as evidenced by the ameliorating effects of replacement therapy in an experimental model of duct ligation-induced acute ..