experimental leukemia

Summary

Summary: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.

Top Publications

  1. Gilliland D, Griffin J. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532-42 pubmed
    ..Taken together, these results suggest that FLT3 is an attractive therapeutic target for kinase inhibitors or other approaches for patients with mutations of this gene...
  2. Mishra S, Zhang B, Groffen J, Heisterkamp N. A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl. Leukemia. 2004;18:23-8 pubmed
    ..We conclude that SCH66336, on its own, is remarkably effective in eradicating large numbers of lymphoblastic lymphoma cells and causing visible reduction in tumor size, with minimal toxicity...
  3. Gao L, Chen L, Fei X, Qiu H, Zhou H, Wang J. STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model. Chin Med J (Engl). 2006;119:911-8 pubmed
    ..Since STI571 may reverse multidrug-resistance of K562/MDR cells in vitro, we studied the effect of STI571 on multidrug-resistant K562 cells in vivo...
  4. Gourzi P, Leonova T, Papavasiliou F. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Immunity. 2006;24:779-86 pubmed
    ..Hence, in addition to its known function in immunoglobulin diversification, AID is active in innate defense against a transforming retrovirus...
  5. Kaur P, Feldhahn N, Zhang B, Trageser D, MUSCHEN M, Pertz V, et al. Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia. Mol Cancer. 2007;6:67 pubmed
    ..Because Ph-positive acute lymphoblastic leukemia only responds transiently to imatinib therapy, we have used mouse models to test the efficacy of nilotinib against lymphoblastic leukemia caused by the P190 form of Bcr/Abl...
  6. Jung Y, Kozak C. Generation of novel syncytium-inducing and host range variants of ecotropic moloney murine leukemia virus in Mus spicilegus. J Virol. 2003;77:5065-72 pubmed
    ..dunni...
  7. Vasmel W, Zijlstra M, Radaszkiewicz T, Leupers C, de Goede R, Melief C. Major histocompatibility complex class II-regulated immunity to murine leukemia virus protects against early T- but not late B-cell lymphomas. J Virol. 1988;62:3156-66 pubmed
    ..We conclude that the pleiotropic effects of MCF 1233 infection in H-2-congenic mice result from MHC class II I-A-determined T-cell response differences...
  8. Chen W, Qin H, Chesebro B, Cheever M. Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. J Virol. 1996;70:7773-82 pubmed
    ..Thus, the CTL epitope of FBL-3 is localized to the transmembrane anchor domain of the nonstructural Gag polyprotein and is shared by leukemia/lymphoma cell lines induced by Friend, Moloney, and Rauscher MuLV...
  9. James R, Edwards S, Hui K, Bassett P, Grosveld F. The effect of class II gene transfection on the tumourigenicity of the H-2K-negative mouse leukaemia cell line K36.16. Immunology. 1991;72:213-8 pubmed
    ..This suggests that the induction of class II antigen expression on tumour cells may provide an effective way of enhancing tumour-specific immune responses in vivo...
  10. Iwashiro M, Kondo T, Shimizu T, Yamagishi H, Takahashi K, Matsubayashi Y, et al. Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells. J Virol. 1993;67:4533-42 pubmed
    ..In addition, a possible third epitope was located in the N-terminal half of the gp70 sequence and differed from the first epitope in that it was not cross-reactive with the Moloney MuLV envelope protein...

Detail Information

Publications62

  1. Gilliland D, Griffin J. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532-42 pubmed
    ..Taken together, these results suggest that FLT3 is an attractive therapeutic target for kinase inhibitors or other approaches for patients with mutations of this gene...
  2. Mishra S, Zhang B, Groffen J, Heisterkamp N. A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl. Leukemia. 2004;18:23-8 pubmed
    ..We conclude that SCH66336, on its own, is remarkably effective in eradicating large numbers of lymphoblastic lymphoma cells and causing visible reduction in tumor size, with minimal toxicity...
  3. Gao L, Chen L, Fei X, Qiu H, Zhou H, Wang J. STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model. Chin Med J (Engl). 2006;119:911-8 pubmed
    ..Since STI571 may reverse multidrug-resistance of K562/MDR cells in vitro, we studied the effect of STI571 on multidrug-resistant K562 cells in vivo...
  4. Gourzi P, Leonova T, Papavasiliou F. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Immunity. 2006;24:779-86 pubmed
    ..Hence, in addition to its known function in immunoglobulin diversification, AID is active in innate defense against a transforming retrovirus...
  5. Kaur P, Feldhahn N, Zhang B, Trageser D, MUSCHEN M, Pertz V, et al. Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia. Mol Cancer. 2007;6:67 pubmed
    ..Because Ph-positive acute lymphoblastic leukemia only responds transiently to imatinib therapy, we have used mouse models to test the efficacy of nilotinib against lymphoblastic leukemia caused by the P190 form of Bcr/Abl...
  6. Jung Y, Kozak C. Generation of novel syncytium-inducing and host range variants of ecotropic moloney murine leukemia virus in Mus spicilegus. J Virol. 2003;77:5065-72 pubmed
    ..dunni...
  7. Vasmel W, Zijlstra M, Radaszkiewicz T, Leupers C, de Goede R, Melief C. Major histocompatibility complex class II-regulated immunity to murine leukemia virus protects against early T- but not late B-cell lymphomas. J Virol. 1988;62:3156-66 pubmed
    ..We conclude that the pleiotropic effects of MCF 1233 infection in H-2-congenic mice result from MHC class II I-A-determined T-cell response differences...
  8. Chen W, Qin H, Chesebro B, Cheever M. Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. J Virol. 1996;70:7773-82 pubmed
    ..Thus, the CTL epitope of FBL-3 is localized to the transmembrane anchor domain of the nonstructural Gag polyprotein and is shared by leukemia/lymphoma cell lines induced by Friend, Moloney, and Rauscher MuLV...
  9. James R, Edwards S, Hui K, Bassett P, Grosveld F. The effect of class II gene transfection on the tumourigenicity of the H-2K-negative mouse leukaemia cell line K36.16. Immunology. 1991;72:213-8 pubmed
    ..This suggests that the induction of class II antigen expression on tumour cells may provide an effective way of enhancing tumour-specific immune responses in vivo...
  10. Iwashiro M, Kondo T, Shimizu T, Yamagishi H, Takahashi K, Matsubayashi Y, et al. Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells. J Virol. 1993;67:4533-42 pubmed
    ..In addition, a possible third epitope was located in the N-terminal half of the gp70 sequence and differed from the first epitope in that it was not cross-reactive with the Moloney MuLV envelope protein...
  11. Anderson G, Palmer G, Rowland R, Even C, Plagemann P. Infection of central nervous system cells by ecotropic murine leukemia virus in C58 and AKR mice and in in utero-infected CE/J mice predisposes mice to paralytic infection by lactate dehydrogenase-elevating virus. J Virol. 1995;69:308-19 pubmed
    ....
  12. Turcotte K, Gauthier S, Mitsos L, Shustik C, Copeland N, Jenkins N, et al. Genetic control of myeloproliferation in BXH-2 mice. Blood. 2004;103:2343-50 pubmed
    ..Our results suggest a model in which Myls-dependent myeloproliferation in BXH-2 acts as a predisposing factor for the subsequent development of virally induced myeloid leukemia characteristic of this strain...
  13. Voisin V, Barat C, Hoang T, Rassart E. Novel insights into the pathogenesis of the Graffi murine leukemia retrovirus. J Virol. 2006;80:4026-37 pubmed
    ..Furthermore, the enhancer region, different for GV-1.2 and GV-1.4, plays a pivotal role in the disease specificity: GV-1.2 induces more lymphoid leukemias, and GV-1.4 induces more nonlymphoid ones...
  14. Mayhew C, Sumpter R, Inayat M, Cibull M, Phillips J, Elford H, et al. Combination of inhibitors of lymphocyte activation (hydroxyurea, trimidox, and didox) and reverse transcriptase (didanosine) suppresses development of murine retrovirus-induced lymphoproliferative disease. Antiviral Res. 2005;65:13-22 pubmed
    ..Moreover, the novel RR inhibitors TX and DX appear to be more effective and less myelosuppressive than HU when administered with ddI in this model...
  15. Stromnes I, Dittmer U, Schumacher T, Schepers K, Messer R, Evans L, et al. Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice. J Virol. 2002;76:2225-32 pubmed
    ..Eventually, all of the IFN-gamma-deficient mice failed to keep persistent virus in check and developed fatal FV-induced erythroleukemia...
  16. Louz D, van Den Broek M, Verbakel S, Vankan Y, van Lom K, Joosten M, et al. Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic mice. Leukemia. 2000;14:1876-84 pubmed
    ..Taken together, our results present the first evidence of Evi1 disturbing normal erythropoiesis in vivo and provides evidence for cooperative potential of Evi1 in tumor progression...
  17. Ishii T, Udono H, Yamano T, Ohta H, Uenaka A, Ono T, et al. Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96. J Immunol. 1999;162:1303-9 pubmed
    ..The implication of this evidence is also discussed in terms of the roles of hsps in MHC class I Ag processing/presentation...
  18. Treshchalina E, Andronova N, Kobliakov V, Raikhlin N. [New models of experimental chemotherapy of tumors]. Vopr Onkol. 2001;47:701-5 pubmed
    ..Models of tumorous pleuritis described with respect to their response to chemotherapy, may have an application in screening and preclinical examination of newly-developed antitumor drugs...
  19. Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, et al. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007;13:70-7 pubmed
    ..These findings identify NF-kappaB as one of the major mediators of Notch1-induced transformation and suggest that the NF-kappaB pathway is a potential target of future therapies of T-ALL...
  20. Wittich S, Scherf H, Xie C, Brosch G, Loidl P, Gerhauser C, et al. Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. J Med Chem. 2002;45:3296-309 pubmed
    ..In the amino acid methyl ester series, a biphenylalanine derivative was identified as a good enzyme inhibitor, which blocks proliferation in the submicromolar range and is also a potent inducer of terminal cell differentiation...
  21. Hu Z, Zou P, Li A, Zhang Y, Wang L, Liu L. Study on blocking the leukemia immune escape after BMT by Fas-Fas ligand pathway. Chin Med J (Engl). 2004;117:419-24 pubmed
    ....
  22. Krivtsov A, Wang Y, Feng Z, Armstrong S. Gene expression profiling of leukemia stem cells. Methods Mol Biol. 2009;538:231-46 pubmed publisher
    ..Here we describe methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses...
  23. Ye K, Dhiman H, Suhan J, Schultz J. Effect of pH on infectivity and morphology of ecotropic moloney murine leukemia virus. Biotechnol Prog. 2003;19:538-43 pubmed
    ..A FACS-based screening strategy for selecting high-titer retrovirus producing cell lines is also presented in this report...
  24. Josipović P, Orsolic N. [Cytotoxicity of polyphenolic/flavonoid compounds in a leukaemia cell culture]. Arh Hig Rada Toksikol. 2008;59:299-308 pubmed publisher
    ..These results suggest a biphase effect of the tested compounds on monocyte cell lines. Cytotoxicity and growth stimulation mechanisms caused directly by flavonoids should further be investigated on the molecular level...
  25. Al Bagdadi F, Seger C, Henry R, Neal Maulden G. Acute lymphoblast leukemia in sheep induced by inoculation of bovine leukemia virus: diagnostic electron microscopic morphological study. Ultrastruct Pathol. 2006;30:85-94 pubmed
    ..This study shows abundant cytoplasmic processes of hairy cell leukemia. The nuclei of the leukemia lymphoblasts showed electron-dense granules of varying sizes, which were not seen in any of the normal lymphoblasts...
  26. William B, Goodrich A, Peng C, Li S. Curcumin inhibits proliferation and induces apoptosis of leukemic cells expressing wild-type or T315I-BCR-ABL and prolongs survival of mice with acute lymphoblastic leukemia. Hematology. 2008;13:333-43 pubmed publisher
    ..We tested whether curcumin has an inhibitory effect on BCR-ABL B-cell acute lymphoblastic leukemia (B-ALL) in vitro and in vivo...
  27. Wolff L, Koller R, Hu X, Anver M. A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms. J Virol. 2003;77:4965-71 pubmed
    ..Interesting, MCF recombinant envelope was expressed in the lymphoid but not the myeloid neoplasms of BALB/c mice. This retrovirus has the potential for accelerating myeloid disease in genetically engineered mice...
  28. Mayhew C, Mampuru L, Chendil D, Ahmed M, Phillips J, Greenberg R, et al. Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea. Antiviral Res. 2002;56:167-81 pubmed
    ..These results suggest that due to their reduced hematopoietic toxicity and ability to inhibit disease progression in murine AIDS, TX and DX may offer effective alternatives to HU therapy in HIV-1 infection...
  29. Rakhra K, Bachireddy P, Zabuawala T, Zeiser R, Xu L, Kopelman A, et al. CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell. 2010;18:485-98 pubmed publisher
    ..Hence, CD4(+) T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction...
  30. Caudell D, Harper D, Novak R, Pierce R, Slape C, Wolff L, et al. Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice. Blood. 2010;115:1194-203 pubmed publisher
    ..Three mutations were identified, all of which occurred in mice with Zeb2 integrations, consistent with the hypothesis that Zeb2 and Ras pathway activation promotes B-lineage leukemic transformation in concert with CALM-AF10...
  31. Li H, Li H, Li W, Xiao L, Jiang Z, Li M, et al. [Apoptosis of cancer cells induced by influenza virus and its elementary mechanism]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2003;34:409-12 pubmed
    ..To study the apotosis-inducing effects of influenza virus on cancer cells and the role of FasL...
  32. Chervinsky D, Lam D, Zhao X, Melman M, Aplan P. Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice. Leukemia. 2001;15:141-7 pubmed
    ..Given that SCL and LMO1 gene activation are both commonly seen in human patients with T cell acute lymphoblastic leukemia, these cell lines may be a useful in vitro model for the human disease...
  33. Tolomeo M, Grimaudo S, Milano S, La Rosa M, Ferlazzo V, Di Bella G, et al. Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines. Br J Pharmacol. 2001;133:306-14 pubmed
    ..These findings appear to support the hypothesis that CMT-8 may represent an interesting lead for the development of a new class of potent apoptosis inducer agents active in multidrug resistant and Fas-ligand resistant malignancies...
  34. Zhang J, Du Ester E, Watson R. Side-stream cigarette smoke accentuates immunomodulation during murine AIDS. Int Immunopharmacol. 2002;2:759-66 pubmed
    ..Thus, the reduction of side-stream cigarette smoke exposure is an important health issue in AIDS patients to improve the quality and quantity of their lives...
  35. Arulanandam R, Vultur A, Raptis L. Transfection techniques affecting Stat3 activity levels. Anal Biochem. 2005;338:83-9 pubmed
    ..These results indicate that caution is required in the interpretation of results with regard to activity of Stat3 following certain commonly used transient transfection regimens...
  36. Aster J, Pear W. Notch signaling in leukemia. Curr Opin Hematol. 2001;8:237-44 pubmed
    ..Future studies are expected to elucidate the mechanisms by which Notch leads to transformation. Identification of the transcriptional targets of Notch signaling is likely to yield important insights...
  37. Eriksson M, Leitz G, Fällman E, Axner O, Ryan J, Nakamura M, et al. Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets. J Exp Med. 1999;190:1005-12 pubmed
    ..Thus, although Ly49-mediated inhibitory signals can prevent many types of effector responses, they do not globally inhibit cellular function, but rather the inhibitory signal is spatially restricted towards resistant targets...
  38. Chatterjee S, Basak P, Das M, Das P, Pereira J, Dutta R, et al. Kinetic impairment of haemopoietic stem cells in experimentally induced leukemia and aplastic anemia: an inverse correlation. J Stem Cells. 2009;4:179-89 pubmed
    ..The investigations made so far revealed an interesting correlation between disease initiation and specific cytokinetic involvement of HSC in the BM microenvironment with particular reference to leukemia and aplastic anemia...
  39. Peterson K, Iwashiro M, Hasenkrug K, Chesebro B. Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia. J Virol. 2000;74:5363-7 pubmed
    ..Furthermore, the influence of MHC class I genotype on the generation of both IFN-gamma-producing CD4(+) and CD8(+) T cells helps explain the major impact of the H-2D gene on recovery from FV disease...
  40. Currier N, Miller S. Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life span. J Altern Complement Med. 2001;7:241-51 pubmed
    ..Based on this evidence, our goal in the present work was to assess the role of dietary administration of this herbal extract to mice bearing leukemia, a type of tumor well known to be a target for NK cells...
  41. Rulli S, Muriaux D, Nagashima K, Mirro J, Oshima M, Baumann J, et al. Mutant murine leukemia virus Gag proteins lacking proline at the N-terminus of the capsid domain block infectivity in virions containing wild-type Gag. Virology. 2006;347:364-71 pubmed
    ..The results imply that CA proteins function as part of a large, highly organized structure in reverse transcription and apparently at a later step as well...
  42. Koustova E, Sei Y, Fossom L, Wei M, Usherwood P, Keele N, et al. LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor. J Clin Invest. 2001;107:737-44 pubmed
    ..These Ab's may alter neuronal signaling and contribute to the neurodegeneration observed in these mice, actions that may be curtailed by the use of AMPA-receptor antagonists...
  43. Lin S, Sheen L, Chiang B, Yang J, Pan J, Chang Y, et al. Dietary effect of Antrodia Camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice. Nutr Cancer. 2010;62:593-600 pubmed publisher
    ..camphorata at 4 mg/kg in target cells at a ratio of 50:1. The percentage of macrophages with phagocyted at A. camphorata treatment increased, and these effects were in dose-dependent manners...
  44. Somervaille T, Cleary M. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 2006;10:257-68 pubmed
    ....
  45. Zhu Z, Hattori K, Zhang H, Jimenez X, Ludwig D, Dias S, et al. Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity. Leukemia. 2003;17:604-11 pubmed
    ..It further underscores the efforts to identify antibodies of high affinity for enhanced antiangiogenic and antitumor activities...
  46. Sørensen K, Kunder S, Quintanilla Martinez L, Sørensen J, Schmidt J, Pedersen F. Enhancer mutations of Akv murine leukemia virus inhibit the induction of mature B-cell lymphomas and shift disease specificity towards the more differentiated plasma cell stage. Virology. 2007;362:179-91 pubmed
    ..Our results indicate that enhancer mutations weaken the ability of Akv to induce mature B-cell lymphomas prior to the plasma cell stage, whereas development of plasma cell proliferations is less dependent of viral enhancer strength...
  47. Slavin S, Morecki S, Weiss L, Or R. Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man. Crit Rev Oncol Hematol. 2003;46:139-63 pubmed
    ....
  48. Modlich U, Schambach A, Brugman M, Wicke D, Knoess S, Li Z, et al. Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16. Leukemia. 2008;22:1519-28 pubmed publisher
    ..Our study also shows that insertional mutagenesis is required for leukemia induction by IL2RG vectors, a risk to be addressed by improved vector design...
  49. Honda H. [Analysis of molecular mechanisms for leukemogenesis using disease models]. Nihon Rinsho. 2007;65 Suppl 1:24-33 pubmed
  50. Zeis M, Uharek L, Hartung G, Glass B, Steinmann J, Schmitz N. Graft-vs-leukemia activity and graft-vs-host disease induced by allogeneic Th1- and Th2-type CD4+ T cells in mice. Hematol J. 2001;2:136-44 pubmed
    ..Therefore, separation of GVL- and GVH-reactions is a long-standing goal of experimental studies dealing with allogeneic transplantation of hematopoietic stem cells...
  51. Schlecht Louf G, Renard M, Mangeney M, Letzelter C, Richaud A, Ducos B, et al. Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses. Proc Natl Acad Sci U S A. 2010;107:3782-7 pubmed publisher
    ....
  52. Schuch G, Machluf M, Bartsch G, Nomi M, Richard H, Atala A, et al. In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo. Blood. 2002;100:4622-8 pubmed
    ..The use of VEGF antagonists as an antiangiogenesis approach offers a potential treatment for AML. Finally, our novel in vivo drug delivery model may be useful for testing the activities of other peptide antiangiogenic factors...
  53. Li X, Chen Q, Ye Y, Fan L, Chen M, Li J, et al. [Effects of NKG2D and its ligands RAE-1 and H60 on graft-versus-tumor response]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007;15:160-4 pubmed
    ..It is concluded that NKG2D and its ligands RAE-1 and H60 may play important roles in GVT response...
  54. Jankovicova K, Krejsek J, Kopecky O. [Multidrug resistance of leukemia cells to cytostatics--the functional fluorescent dye efflux assay evaluated by flow cytometry]. Vnitr Lek. 2001;47:25-9 pubmed
    ..The cell line K562 with transfected P-glycoprotein gene serves as a model system for the studying of the transport function with the use of the fluorescent substrates and P-glycoprotein inhibitors...
  55. Minegishi N, Suzuki N, Kawatani Y, Shimizu R, Yamamoto M. Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway. Genes Cells. 2005;10:693-704 pubmed
    ..We also detected poly ubiquitinated forms of GATA-2. Taken together, these results demonstrate that GATA-2 is turned over rapidly through the ubiquitin-proteasome pathway...
  56. Ni S, Zhao C, Feng G, Paulson R, Correll P. A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection. Mol Cell Biol. 2007;27:3708-15 pubmed
    ....
  57. Ott R, Simma O, Kollmann K, Weisz E, Zebedin E, Schorpp Kistner M, et al. JunB is a gatekeeper for B-lymphoid leukemia. Oncogene. 2007;26:4863-71 pubmed
    ..Thus, JunB functions as a gatekeeper during tumor evolution. In its absence, transformed leukemic cells acquire an enhanced proliferative capacity, which presages a more malignant disease...
  58. Yoshimura F, Wang T. Role of the LTR region between the enhancer and promoter in mink cell focus-forming murine leukemia virus pathogenesis. Virology. 2001;283:121-31 pubmed
    ..The lack of DEN virus expression by tumor cells led us to propose that DEN sequences may play a role at an early step in tumorigenesis...
  59. Walters D, Mercher T, Gu T, O Hare T, Tyner J, Loriaux M, et al. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 2006;10:65-75 pubmed
    ..These findings illustrate the biological importance of gain-of-function JAK3 mutations in leukemogenesis and demonstrate the utility of proteomic approaches to identifying clinically relevant mutations...
  60. Ben Eliyahu S, Page G, Yirmiya R, Shakhar G. Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. Int J Cancer. 1999;80:880-8 pubmed
    ..Clinical circumstances in which surgical stress may induce enhanced metastatic growth are discussed...
  61. Eguchi M, Eguchi Ishimae M, Green A, Enver T, Greaves M. Directing oncogenic fusion genes into stem cells via an SCL enhancer. Proc Natl Acad Sci U S A. 2005;102:1133-8 pubmed
    ..These data indicate that related oncogenic fusion proteins similarly expressed in a hierarchy of early stem cells can have selective, cell type-specific developmental impacts...
  62. Zhang J, Randall M, Loyd M, Li W, Schweers R, Persons D, et al. Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia. Blood. 2006;107:73-8 pubmed
    ..These results suggest that Friend virus activates both sf-STK and the EPOR to cause deregulated erythroid proliferation and differentiation...