limbic system

Summary

Summary: A set of forebrain structures common to all mammals that is defined functionally and anatomically. It is implicated in the higher integration of visceral, olfactory, and somatic information as well as homeostatic responses including fundamental survival behaviors (feeding, mating, emotion). For most authors, it includes the AMYGDALA; EPITHALAMUS; GYRUS CINGULI; hippocampal formation (see HIPPOCAMPUS); HYPOTHALAMUS; PARAHIPPOCAMPAL GYRUS; SEPTAL NUCLEI; anterior nuclear group of thalamus, and portions of the basal ganglia. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p744; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (September 2, 1998)).

Top Publications

  1. ncbi Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects
    K K Hui
    MGH NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Hum Brain Mapp 9:13-25. 2000
  2. ncbi Limbic-cortical dysregulation: a proposed model of depression
    H S Mayberg
    Department of Medicine Neurology, University of Texas Health Science Center at San Antonio 78284 6240, USA
    J Neuropsychiatry Clin Neurosci 9:471-81. 1997
  3. ncbi Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study
    Amit Anand
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biol Psychiatry 57:1079-88. 2005
  4. ncbi Differential projections of the infralimbic and prelimbic cortex in the rat
    Robert P Vertes
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA
    Synapse 51:32-58. 2004
  5. ncbi Neural mechanisms of aggression
    Randy J Nelson
    Department of Psychology, Institute for Behavioural Medicine Research, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Neurosci 8:536-46. 2007
  6. pmc Habenula: crossroad between the basal ganglia and the limbic system
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 28:11825-9. 2008
  7. ncbi Defective limbic system in mice lacking the tailless gene
    A P Monaghan
    Division of Molecular Biology of the Cell I, German Cancer Research Centre, Heidelberg
    Nature 390:515-7. 1997
  8. ncbi The rewards of music listening: response and physiological connectivity of the mesolimbic system
    V Menon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
    Neuroimage 28:175-84. 2005
  9. ncbi Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system
    Hsiun Ing Chen
    Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Neurobiol Learn Mem 89:489-96. 2008
  10. ncbi Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy
    Tomas Furmark
    Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
    Arch Gen Psychiatry 59:425-33. 2002

Research Grants

  1. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
  2. Walter H Kaye; Fiscal Year: 2015
  3. Cecilia J Hillard; Fiscal Year: 2014
  4. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    Larry W Swanson; Fiscal Year: 2012
  5. Susan M Rivera; Fiscal Year: 2016
  6. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2013
  7. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
  8. Assessing the Influence of Oxytocin on Postpartum Depression Using Brain Imaging
    Julia R Heiman; Fiscal Year: 2010
  9. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
  10. Gene-environment interaction: the brain CRF system in alcohol preferring msP rats
    Marisa Roberto; Fiscal Year: 2013

Detail Information

Publications340 found, 100 shown here

  1. ncbi Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects
    K K Hui
    MGH NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Hum Brain Mapp 9:13-25. 2000
    ..These preliminary results suggest that acupuncture needle manipulation modulates the activity of the limbic system and subcortical structures...
  2. ncbi Limbic-cortical dysregulation: a proposed model of depression
    H S Mayberg
    Department of Medicine Neurology, University of Texas Health Science Center at San Antonio 78284 6240, USA
    J Neuropsychiatry Clin Neurosci 9:471-81. 1997
    ....
  3. ncbi Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study
    Amit Anand
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biol Psychiatry 57:1079-88. 2005
    ..In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls...
  4. ncbi Differential projections of the infralimbic and prelimbic cortex in the rat
    Robert P Vertes
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA
    Synapse 51:32-58. 2004
    ....
  5. ncbi Neural mechanisms of aggression
    Randy J Nelson
    Department of Psychology, Institute for Behavioural Medicine Research, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Neurosci 8:536-46. 2007
    ..This Review summarizes the complex interactions between genes, biological signals, neural circuits and the environment that influence the development and expression of aggressive behaviour...
  6. pmc Habenula: crossroad between the basal ganglia and the limbic system
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 28:11825-9. 2008
    ..Further, dysfunctions of the LHb have also been implicated in psychiatric disorders, such as depression, schizophrenia, and drug-induced psychosis...
  7. ncbi Defective limbic system in mice lacking the tailless gene
    A P Monaghan
    Division of Molecular Biology of the Cell I, German Cancer Research Centre, Heidelberg
    Nature 390:515-7. 1997
    ..These animals therefore enable a molecular approach to be taken towards understanding the genetic architecture and morphogenesis of the forebrain...
  8. ncbi The rewards of music listening: response and physiological connectivity of the mesolimbic system
    V Menon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
    Neuroimage 28:175-84. 2005
    ....
  9. ncbi Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system
    Hsiun Ing Chen
    Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Neurobiol Learn Mem 89:489-96. 2008
    ..Our results suggest that down-regulation of the 5-HT system in the limbic system, i.e...
  10. ncbi Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy
    Tomas Furmark
    Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
    Arch Gen Psychiatry 59:425-33. 2002
    ..Neurofunctional changes underlying effective antianxiety treatments are incompletely characterized. This study explored the effects of citalopram and cognitive-behavioral therapy on regional cerebral blood flow (rCBF) in social phobia...
  11. pmc Acupuncture, the limbic system, and the anticorrelated networks of the brain
    Kathleen K S Hui
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Auton Neurosci 157:81-90. 2010
    ..comprising deqi, evokes deactivation of a limbic-paralimbic-neocortical network, which encompasses the limbic system, as well as activation of somatosensory brain regions...
  12. ncbi The emotional brain, fear, and the amygdala
    Joseph LeDoux
    Center for Neural Science, New York University, New York, USA
    Cell Mol Neurobiol 23:727-38. 2003
    ..3. Before describing research on the role of the amygdala in fear conditioning, though, it will be helpful to briefly examine the historical events that preceded modern research on conditioned fear...
  13. doi Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction
    Vincent Laurent
    School of Psychology, The University of New South Wales, New South Wales, Australia
    Learn Mem 16:520-9. 2009
    ..The role of the IL is discussed in terms of a contemporary neural model of fear extinction...
  14. ncbi Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder
    David Silbersweig
    Department of Psychiatry, Box 140, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Psychiatry 164:1832-41. 2007
    ..Such a finding would provide a plausible neural basis for the difficulty borderline patients have in modulating their behavior during negative emotional states and a potential marker for treatment interventions...
  15. ncbi Pathological gambling is linked to reduced activation of the mesolimbic reward system
    Jan Reuter
    NeuroImage Nord, Department of Neurology, Hamburg University Hospital Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Nat Neurosci 8:147-8. 2005
    ....
  16. ncbi The neural bases of amusement and sadness: a comparison of block contrast and subject-specific emotion intensity regression approaches
    Philippe R Goldin
    Department of Psychology, Stanford University, Stanford, CA 94305 2130, USA
    Neuroimage 27:26-36. 2005
    ....
  17. doi Corticosteroid effects on cellular physiology of limbic cells
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Brain Res 1293:91-100. 2009
    ..Finally, the time- and region-specific corticosteroid actions strongly depend on the individual's life history...
  18. pmc Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear
    Ivan Vidal-Gonzalez
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    Learn Mem 13:728-33. 2006
    ..We suggest that PL excites amygdala output and IL inhibits amygdala output, providing a mechanism for bidirectional modulation of fear expression...
  19. ncbi Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies
    Jens C Pruessner
    Center for Studies on Human Stress, Douglas Hospital Research Center and Montreal Neurological Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 63:234-40. 2008
    ..Newly developed paradigms to investigate stress in neuroimaging environments allow the assessment of brain activation changes in association with the perception of and the metabolic response to stress...
  20. doi Lactobacillus helveticus and Bifidobacterium longum taken in combination reduce the apoptosis propensity in the limbic system after myocardial infarction in a rat model
    Stéphanie Anne Girard
    Centre de Biomédicine, Hopital du Sacre Coeur de Montreal, 5400 Boulevard Gouin Ouest, Montreal, Que, Canada H4J 1C5
    Br J Nutr 102:1420-5. 2009
    Myocardial infarction (MI) stimulates the release of pro-inflammatory substances that induce apoptosis in the limbic system. Pro-inflammatory cytokines are considered as the root cause of apoptosis, although the mechanism is not fully ..
  21. pmc Extrahippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy
    Leonardo Bonilha
    Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Epilepsia 51:519-28. 2010
    ..This study aimed to investigate the relationship between hippocampal deafferentation and brain atrophy in MTLE...
  22. ncbi Serotonergic modulation of the limbic system
    Julie G Hensler
    Department of Pharmacology, MC 7764, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neurosci Biobehav Rev 30:203-14. 2006
    The limbic system is composed of cortical as well as subcortical structures, which are intimately interconnected. The resulting macrostructure is responsible for the generation and expression of motivational and affective states...
  23. doi Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies
    Valentina Lorenzetti
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, Australia
    J Affect Disord 117:1-17. 2009
    ..While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear...
  24. pmc Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
    Michael Rosenbaum
    Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University Medical Center New York Presbyterian Medical Center, New York, New York, USA
    J Clin Invest 118:2583-91. 2008
    ..These data are consistent with a model of the weight-reduced state as one of relative leptin deficiency...
  25. ncbi Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging
    Deborah L Due
    Department of Psychological and Brain Sciences, Duke University, Durham, NC 27709, USA
    Am J Psychiatry 159:954-60. 2002
    ..The authors sought to increase understanding of the brain mechanisms involved in cigarette addiction by identifying neural substrates modulated by visual smoking cues in nicotine-deprived smokers...
  26. ncbi Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness
    James P Herman
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Front Neuroendocrinol 24:151-80. 2003
    ..Imbalances among these limbic pathways and homeostatic sensors are likely to underlie hypothalamo-pituitary-adrenocortical dysfunction associated with numerous disease processes...
  27. ncbi Limbic-frontal circuitry in major depression: a path modeling metanalysis
    D A Seminowicz
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Neuroimage 22:409-18. 2004
    ....
  28. doi Major depressive disorder and white matter abnormalities: a diffusion tensor imaging study with tract-based spatial statistics
    Tuula Kieseppä
    Department of Mental Health and Alcohol Research, National Public Heath Institute, Finland
    J Affect Disord 120:240-4. 2010
    ..In this study, we explored the structure of the white matter of the whole brain with DTI in middle-aged major depressive disorder (MDD) patients, using novel tract-based spatial statistics...
  29. ncbi Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events
    Amar Sahay
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 23:6671-80. 2003
    ..Thus, our results show that Sema3F is the principal ligand for Npn-2-mediated axon guidance events in vivo and is a critical determinant of limbic and peripheral nervous system circuitry...
  30. doi Towards a neural basis of music-evoked emotions
    Stefan Koelsch
    Cluster of Excellence Languages of Emotion, Freie Universitat Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany
    Trends Cogn Sci 14:131-7. 2010
    ..Because dysfunctions in these structures are related to emotional disorders, a better understanding of music-evoked emotions and their neural correlates can lead to a more systematic and effective use of music in therapy...
  31. ncbi Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression
    M Bauer
    Neuropsychiatric Institute and Hospital, University of California Los Angeles, CA, USA
    Mol Psychiatry 10:456-69. 2005
    ..We conclude that bipolar depressed patients have abnormal function in prefrontal and limbic brain areas. L-T(4) may improve mood by affecting circuits involving these areas, which have been previously implicated in affective disorders...
  32. ncbi Early postnatal stress confers enduring vulnerability to limbic epileptogenesis
    Michael Salzberg
    Department of Psychiatry, University of Melbourne, and St Vincent s Mental Health Service, St Vincent s Hospital, Melbourne, Fitzroy, Victoria 3065, Australia
    Epilepsia 48:2079-85. 2007
    ..In rats, we tested the hypothesis that early postnatal stress, in the form of maternal separation (MS), creates vulnerability to limbic epileptogenesis in adult life...
  33. ncbi Prefrontal cortical networks related to visceral function and mood
    J L Price
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 877:383-96. 1999
    ..Many of these areas also show volume changes and decreased glial number and density in mood-disordered subjects...
  34. ncbi Modulating limbic-cortical circuits in depression: targets of antidepressant treatments
    Helen S Mayberg
    Department of Psychiatry, University of Toronto, Ontario, Canada
    Semin Clin Neuropsychiatry 7:255-68. 2002
    ....
  35. ncbi Inactivation of the infralimbic prefrontal cortex reinstates goal-directed responding in overtrained rats
    Etienne Coutureau
    School of Psychology, Cardiff University, PO Box 901, Park Place, Cardiff, CF10 3YG, UK
    Behav Brain Res 146:167-74. 2003
    ..This suggests that the development of habitual responding reflects the active inhibition of goal-directed responses that are mediated by action-outcome associations...
  36. ncbi Something funny happened to reward
    Gregory S Berns
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30328, USA
    Trends Cogn Sci 8:193-4. 2004
    ..Now, a recent fMRI study has found mesolimbic reward activation associated with humorous cartoons, providing a neurobiological link between theories of humour and hedonic processes in the brain...
  37. ncbi Prefrontal cortex in the rat: projections to subcortical autonomic, motor, and limbic centers
    Paul L A Gabbott
    University Department of Pharmacology, Oxford, OX1 3QT United Kingdom
    J Comp Neurol 492:145-77. 2005
    ....
  38. ncbi Specific configuration of dendritic degeneration in pyramidal neurons of the medial prefrontal cortex induced by differing corticosteroid regimens
    João J Cerqueira
    Life and Health Sciences Research Institute Instituto de Investigação em ciências da vida e da saúde, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Cereb Cortex 17:1998-2006. 2007
    ..None of the treatments influenced the architecture of the basal dendrites. These results add to our knowledge of the morphological substrates through which corticosteroids may disrupt mPFC-dependent behaviors...
  39. ncbi Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:2301-9. 2007
    ....
  40. doi A revised limbic system model for memory, emotion and behaviour
    Marco Catani
    Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, UK Electronic address
    Neurosci Biobehav Rev 37:1724-37. 2013
    Emotion, memories and behaviour emerge from the coordinated activities of regions connected by the limbic system. Here, we propose an update of the limbic model based on the seminal work of Papez, Yakovlev and MacLean...
  41. pmc Limbic activation during cue-induced cocaine craving
    A R Childress
    Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Psychiatry 156:11-8. 1999
    ..Since signals for cocaine induce limbic brain activation in animals and cocaine craving in humans, the objective of this study was to test whether limbic activation occurs during cue-induced craving in humans...
  42. doi Analysis of the anatomy of the Papez circuit and adjoining limbic system by fiber dissection techniques
    Abhidha Shah
    Department of Neurosurgery, Seth G S Medical College and King Edward VII Memorial Hospital, Acharya Donde Marg, Parel, Mumbai 400012, India
    J Clin Neurosci 19:289-98. 2012
    Fiber dissection techniques were used to study the limbic system, in particular the Papez circuit. The course, length and anatomical relations of the structures that make up the Papez circuit were delineated...
  43. ncbi Expression of the mRNAs encoding the limbic system-associated membrane protein (LAMP): I. Adult rat brain
    B S Reinoso
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway 08854
    J Comp Neurol 375:274-88. 1996
    ..One such molecule is the limbic system-associated membrane protein (LAMP), a 64-68 kDa glycoprotein that is expressed in the soma and dendrites of ..
  44. ncbi Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 61:877-89. 2004
    ..Depression is associated with interpersonal difficulties related to abnormalities in affective facial processing...
  45. ncbi Feeling the real world: limbic response to music depends on related content
    Eran Eldar
    Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Israel
    Cereb Cortex 17:2828-40. 2007
    ....
  46. ncbi Gene expression of mineralocorticoid and glucocorticoid receptors in the limbic system is related to type-2 like diabetes in leptin-resistant rats
    Olaf Jöhren
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    Brain Res 1184:160-7. 2007
    ..of the HPA axis in rats with ZDF background is associated with a differential expression of GR and MR in the limbic system. This dysregulation of the HPA axis may eventually lead, in combination with leptin resistance, to the ..
  47. doi Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder
    Xiaohua Cao
    Institute of Mental Health, Peking University, Beijing 100191, China
    Brain Res 1303:195-206. 2009
    ..The above results suggest that abnormal functional relationships between the putamen and the cortical-striatal-thalamic circuits as well as the default mode network may underlie the pathological basis of ADHD...
  48. ncbi The debate over dopamine's role in reward: the case for incentive salience
    Kent C Berridge
    Department of Psychology, University of Michigan, 530 Church Street East Hall, Ann Arbor, MI 48109, USA
    Psychopharmacology (Berl) 191:391-431. 2007
    ..Results from studies that exploited those opportunities are described here...
  49. ncbi Cortical and limbic activation during viewing of high- versus low-calorie foods
    William D S Killgore
    Cognitive Neuroimaging Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuroimage 19:1381-94. 2003
    ....
  50. ncbi Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy
    Kimberly Goldapple
    Rotman Research Institute at Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Arch Gen Psychiatry 61:34-41. 2004
    ..Functional imaging studies of major depressive disorder demonstrate response-specific regional changes following various modes of antidepressant treatment...
  51. doi Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease
    Andrew King
    Department of Clinical Neuropathology, King s College Hospital, London, UK
    Neuropathology 30:408-19. 2010
    ..This raises the question as to whether there may be some shared pathogenic mechanisms between the two conditions...
  52. pmc Parallel but separate inputs from limbic cortices to the mammillary bodies and anterior thalamic nuclei in the rat
    Nicholas F Wright
    School of Psychology, Cardiff University, Cardiff, CF10 3AT, United Kingdom
    J Comp Neurol 518:2334-54. 2010
    ..These limbic projections to the mammillary bodies and anterior thalamus comprise a circuit that is vital for memory, within which the two major components could convey parallel, independent information...
  53. doi Neurotransmitters and prefrontal cortex-limbic system interactions: implications for plasticity and psychiatric disorders
    Alberto Del Arco
    Department of Physiology, Faculty of Medicine, Universidad Complutense, Madrid, Spain
    J Neural Transm (Vienna) 116:941-52. 2009
    ..Finally, it is speculated that changes in the function of the PFC, associated with psychiatric disorders or due to environmental-dependent plasticity, can change PFC-limbic system interactions.
  54. ncbi The mesolimbic dopamine reward circuit in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 59:1151-9. 2006
    ....
  55. ncbi Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regions
    Joseph L Price
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1121:54-71. 2007
    ....
  56. ncbi Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's disease
    Ruediger Hilker
    Departments of Neurology and dagger Stereotaxy and Functional Neurosurgery, University Hospital, Cologne, Germany
    J Cereb Blood Flow Metab 24:7-16. 2004
    ..These data suggest an activating effect of DBS upon its target structures and confirm a central role of the STN in motor as well as associative, limbic, and cerebellar basal ganglia circuits...
  57. pmc Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens
    Alexis Faure
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
    J Neurosci 28:7184-92. 2008
    ..Thus, dopamine interacts with localization of valence-biased glutamate circuits in medial shell to facilitate keyboard stimulation of both appetitive and fearful motivations...
  58. ncbi Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression
    S H Kennedy
    Mood and Anxiety Disorders Program, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 158:899-905. 2001
    ..The aim of the present study was to assess the effects of successful paroxetine treatment on regional glucose metabolism in patients with major depression...
  59. pmc Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
    Am J Psychiatry 159:1642-52. 2002
    ..Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction...
  60. doi Reversible disconnection of the hippocampal-prelimbic cortical circuit impairs spatial learning but not passive avoidance learning in rats
    Gong Wu Wang
    Laboratory of Brain and Behavior, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, PR China
    Neurobiol Learn Mem 90:365-73. 2008
    ..The results suggested that spatial learning depends on the Hip-PLC circuit, whereas passive avoidance learning is independent of this circuit...
  61. doi Neurobiological substrates of cue-elicited craving and anhedonia in recently abstinent opioid-dependent males
    Fleur Zijlstra
    Department of Nuclear Medicine, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands
    Drug Alcohol Depend 99:183-92. 2009
    ..The neural correlates of cue-induced craving and anhedonia in opioid-dependent patients are, however, not well understood. We studied brain activation patterns following visual presentation of neutral, pleasant and heroin-related cues...
  62. doi The prefrontal-limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia
    Prog Neurobiol 93:468-87. 2011
    ..Here the likely mechanisms by which these modulations are affected are described and the implications of their failure for depression associated with suicidal diathesis, late-life and psychoses discussed...
  63. pmc GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal H3A 2B4 Quebec, Canada
    Prog Neurobiol 95:104-32. 2011
    ....
  64. ncbi Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system
    Philippe Remy
    CNRS CEA URA2210, Service Hospitalier Frederic Joliot, CHU Henri Mondor et Faculté de Médecine Paris 12, France
    Brain 128:1314-22. 2005
    ..binding than non-depressed Parkinson's disease cases in the locus coeruleus and in several regions of the limbic system including the anterior cingulate cortex, the thalamus, the amygdala and the ventral striatum...
  65. ncbi A unique membrane protein is expressed on early developing limbic system axons and cortical targets
    H L Horton
    Department of Anatomy, Medical College of Pennsylvania, Philadelphia 19129
    J Neurosci 8:4653-61. 1988
    The limbic system-associated membrane protein (LAMP) is a 64 kDa protein that, in the adult brain, is present in cortical and subcortical regions comprising the limbic system (Levitt, 1984)...
  66. ncbi Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation
    L M Shin
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 156:575-84. 1999
    ....
  67. ncbi Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats
    Trisha A Jenkins
    School of Psychology, Cardiff University, Cardiff CF10 3YG, United Kingdom
    J Neurosci 22:5230-8. 2002
    ..Because many of the same sites are implicated in memory processes in humans (e.g., the hippocampus and retrosplenial cortex), this hypoactivity might contribute to diencephalic amnesia...
  68. ncbi Identification and localization of multiple classic cadherins in developing rat limbic system
    I H Bekirov
    Fishberg Research Center for Neurobiology, Box 1065 Neurobiology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Neuroscience 115:213-27. 2002
    ..As a first step toward investigating the role this family plays in generating limbic system connectivity, we used RT-PCR to amplify type I and type II classic cadherins present in rat hippocampus during ..
  69. ncbi Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Behav Brain Res 146:105-19. 2003
    ..Furthermore, these data provide new insights into the functional organization of the rodent frontal cortex with a particular emphasis on localization of function...
  70. doi Electrophysiological insights into the enduring effects of early life stress on the brain
    Idrish Ali
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Melbourne, Vic, Australia
    Psychopharmacology (Berl) 214:155-73. 2011
    ....
  71. ncbi Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system
    T Ravizza
    Laboratory of Experimental Neurology, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milano, Italy
    Neuroscience 137:301-8. 2006
    ....
  72. ncbi Ventral pallidal neurons code incentive motivation: amplification by mesolimbic sensitization and amphetamine
    Amy J Tindell
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 0607, USA
    Eur J Neurosci 22:2617-34. 2005
    ..Our results support incentive-sensitization predictions and suggest why cues temporally proximal to drug presentation may precipitate cue-triggered relapse in human addicts...
  73. doi The effects of antipsychotic drugs administration on 5-HT1A receptor expression in the limbic system of the rat brain
    M Han
    Centre for Translational Neuroscience, School of Health Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    Neuroscience 164:1754-63. 2009
    ..Aripiprazole and olanzapine may produce adaptation and desensitization of 5-HT1A receptor expression after long term treatment...
  74. ncbi Reduced mRNA expression of neuropeptide Y in the limbic system of tenascin gene disrupted mouse brain
    F Fukamauchi
    Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Neuropeptides 32:265-8. 1998
    ..to affect emotion, circadian rhythm and food intake, and the present results suggest that the some behavioural abnormalities exhibited by TN-mutant mice may be in part due to the low level of expression of NPY mRNA in the limbic system.
  75. ncbi Diffusion tensor tractography of the limbic system
    Luis Concha
    Department of Biomedical Engineering University of Alberta, Edmonton, Alberta, Canada
    AJNR Am J Neuroradiol 26:2267-74. 2005
    The limbic system, relevant to memory and emotion, is an interesting subject of study in healthy and diseased individuals. It consists of a network of gray matter structures interconnected by white matter fibers...
  76. doi Effects of perinatal administration of Bisphenol A on the neuronal nitric oxide synthase expressing system in the hypothalamus and limbic system of CD1 mice
    M Martini
    Laboratory of Neuroendocrinology, Department of Anatomy, Pharmacology and Forensic Medicine, Neuroscience Institute of Turin NIT, University of Torino, Torino, Italy
    J Neuroendocrinol 22:1004-12. 2010
    ..In addition, they confirm that perinatal exposure to endocrine-disrupting chemicals, in particular to BPA, may have a high impact on the organisation of specific neural pathways that can later affect complex behaviours and functions...
  77. pmc Social isolation impairs adult neurogenesis in the limbic system and alters behaviors in female prairie voles
    Claudia Lieberwirth
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
    Horm Behav 62:357-66. 2012
    ..These data warrant further investigation of a possible link between altered neurogenesis within the limbic system and behavioral changes.
  78. ncbi Mesial temporal damage in temporal lobe epilepsy: a volumetric MRI study of the hippocampus, amygdala and parahippocampal region
    N Bernasconi
    Department of Neurology and Neurosurgery, McGill University and Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada
    Brain 126:462-9. 2003
    ..The pattern of atrophy may be explained by cell loss secondary to a disruption of entorhinal-hippocampal connections as a result of privileged electrical dialogue between these two structures...
  79. ncbi New component of the limbic system: Marginal division of the neostriatum that links the limbic system to the basal nucleus of Meynert
    Si Yun Shu
    Institute for Neuroscience of the First Military Medical University, Zhu Jiang Hospital, Guangzhou, People s Republic of China
    J Neurosci Res 71:751-7. 2003
    The limbic system refers to a group of connected neural regions that are associated with motivation, learning, and memory...
  80. ncbi [Cortico-limbic mechanisms of affect regulation in the therapy of depression]
    Detlef E Dietrich
    Abteilung Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, 30623 Hannover
    Psychiatr Prax 34:S287-91. 2007
    ..Studies combining classical antidepressants and mood-stabilizing medication (anticonvulsants and newer neuroleptics) should be performed to substantiate these findings...
  81. ncbi Role of the limbic system in dependence on drugs
    F Rodriguez De Fonseca
    Institute for Drug Dependence Research, Department of Psychobiology, Faculty of Psychology, University Complutense, Madrid, Spain
    Ann Med 30:397-405. 1998
    The limbic system is a group of structurally and functionally related areas of the brain that provides the anatomical substrate for emotions and motivated behaviour, including the circuitry for the stress response and reward-related ..
  82. doi Fos expression following activation of the ventral pallidum in normal rats and in a model of Parkinson's Disease: implications for limbic system and basal ganglia interactions
    Michael S Turner
    M D Ph D Program and the Neuroscience Graduate Program, Loyola University Chicago, Medical Center, Maywood, IL, USA
    Brain Struct Funct 213:197-213. 2008
    ..activation of the VP will alter the activity state of brain regions associated with both the basal ganglia and limbic system, and that this influence would be modified in the Parkinsonian state...
  83. doi Effect of olfactory bulbectomy on adenylyl cyclase activity in the limbic system
    Boubacar Pasto Wann
    Centre de Recherche, Hopital du Sacre Coeur de Montreal, Canada
    Brain Res Bull 79:32-6. 2009
    ..NaF)- and forskolin-stimulated conditions) as well as Gi and Gs protein levels in different regions of the limbic system. Two weeks after surgery and compared to sham controls, OBX rats displayed reduced NaF-stimulated adenylyl ..
  84. ncbi Pioneers of affective neuroscience and early concepts of the emotional brain
    M Peper
    University of Freiburg, Department of Psychology, Niemensstr 10, D 79085 Freiburg, F R G
    J Hist Neurosci 10:58-66. 2001
    ....
  85. ncbi Neuroplasticity in specific limbic system circuits may mediate specific kindling induced changes in animal affect-implications for understanding anxiety associated with epilepsy
    R Adamec
    Department of Psychology, Memorial University, Nfld, A1B 3X9, St John s, Canada
    Neurosci Biobehav Rev 24:705-23. 2000
    ..Taken together, the findings of both studies support the hypothesis that a form of LTP of specific amygdala circuits underlies lasting changes in affect produced by limbic kindling. Clinical implications of these findings are discussed...
  86. ncbi Glucocorticoid feedback increases the sensitivity of the limbic system to stress
    Christian J Cook
    Biomedical and Bioengineering Sector, Hort Research, Private Bag 3123, Hamilton, New Zealand
    Physiol Behav 75:455-64. 2002
    ..This alteration appears dependent on circulatory glucocorticoids...
  87. ncbi Neurotransmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treatment of depression
    Owen M Wolkowitz
    World J Biol Psychiatry 4:98-102. 2003
  88. ncbi Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis
    James P Herman
    Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005
    ..Overall, the influence of the limbic system on the HPA axis is likely the end result of the overall patterning of responses to given stimuli and ..
  89. ncbi The expression of TRH, its receptors and degrading enzyme is differentially modulated in the rat limbic system during training in the Morris water maze
    Argel Aguilar-Valles
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, A P 510 3, Cuernavaca 62210, Morelos, Mexico
    Neurochem Int 50:404-17. 2007
    ..The differential modulation in anterior and posterior portions of the hippocampus is discussed...
  90. ncbi Complementary circuits connecting the orbital and medial prefrontal networks with the temporal, insular, and opercular cortex in the macaque monkey
    Kadharbatcha S Saleem
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 506:659-93. 2008
    ..This system, which is also connected with the entorhinal, parahippocampal, and cingulate/retrosplenial cortex, may be involved in emotion and other self-referential processes...
  91. doi "Juvenile stress" alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: relevance for stress-related psychopathologies
    M M Tsoory
    Department of Psychology, University of Haifa, Haifa, Israel
    J Neurosci Res 88:369-80. 2010
    ..predominantly to higher rates of both mood and anxiety disorders in adulthood and is associated with altered limbic system functioning...
  92. pmc Unconsciously perceived fear in peripheral vision alerts the limbic system: a MEG study
    Dimitri J Bayle
    INSERM, U821, Lyon, France
    PLoS ONE 4:e8207. 2009
    ..Several clues converge to hypothesize that peripheral danger presentation can trigger off a fast arousal network potentially independent of the consciousness spot...
  93. ncbi Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery
    Jennifer C Britton
    Neuroscience Program, University of Michigan, Michigan, USA
    Biol Psychiatry 57:832-40. 2005
    ..The present study examined both PTSD-specific and trauma-specific regional cerebral blood flow (rCBF) patterns during script-driven imagery...
  94. ncbi Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior
    Krista McFarland
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 24:1551-60. 2004
    ..The rise in dopamine within the PFCd initiates reinstatement via a glutamatergic projection to the NAcore...
  95. ncbi The functional role of the subthalamic nucleus in cognitive and limbic circuits
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, University of Maastricht, The Netherlands
    Prog Neurobiol 76:393-413. 2005
    ..In conclusion, it can be stated that the STN has anatomically a central position within the basal ganglia thalamocortical associative and limbic circuits and is functionally a potent regulator of these pathways...
  96. pmc Viral infection and dissemination through the olfactory pathway and the limbic system by Theiler's virus
    Y Wada
    Department of Neurology, University of Utah, Salt Lake City 84132
    Am J Pathol 143:221-9. 1993
    ..the presence of viral antigen in defined regions of the CNS, corresponding to various structures of the limbic system. In addition, we found a different time course for viral spread using two different sites of intracerebral ..
  97. ncbi The identification of a novel cDNA preferentially expressed in the olfactory-limbic system of the adult rat
    D G Schaar
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854 5635, USA
    Brain Res 721:217-28. 1996
    ..initial characterization of a novel cDNA, designated AT1-46, that is preferentially expressed in the olfactory-limbic system of the adult rat brain...
  98. ncbi Perirhinal and postrhinal cortices of the rat: interconnectivity and connections with the entorhinal cortex
    R D Burwell
    Department of Psychology, Brown University, Providence, Rhode Island 02912, USA
    J Comp Neurol 391:293-321. 1998
    ..The perirhinal and postrhinal projections to the entorhinal cortex originate in layers III and V and terminate preferentially in layers II and III...
  99. ncbi The fasciculus retroflexus controls the integrity of REM sleep by supporting the generation of hippocampal theta rhythm and rapid eye movements in rats
    A Valjakka
    Department of Pharmacology, University of Kuopio, Finland
    Brain Res Bull 47:171-84. 1998
    ....
  100. ncbi Multisensory processing in the elaboration of place and head direction responses by limbic system neurons
    Sidney I Wiener
    CNRS Collège de France Laboratoire de Physiologie de la Perception et de l Action, 11 pl Marcelin Berthelot, 75005, Paris, France
    Brain Res Cogn Brain Res 14:75-90. 2002
    ..These characteristics provide these signals with robustness and flexibility, properties particularly suited for cognitive processes such as contextual processing, memory and planning...
  101. ncbi Brain reward circuitry: insights from unsensed incentives
    Roy A Wise
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 36:229-40. 2002
    ..Comparisons of natural and laboratory incentives suggest hypotheses as to why some habits become compulsive and give insights into the roles of reinforcement and of prediction of reinforcement in habit formation...

Research Grants70

  1. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..3-dimensional reconstructions from serial sections of long range axon projections or wiring diagrams of the limbic system, at the axon level and on the size scale of primate brain...
  2. Walter H Kaye; Fiscal Year: 2015
    ..Individuals with AN and BN may share a DA-related ventral limbic system alteration, making them vulnerable to being unable to appropriately response to the rewarding aspects of ..
  3. Cecilia J Hillard; Fiscal Year: 2014
    ..antagonists on the phosphorylation and activities of Akt and GSK-3 in brain regions, particularly those of the limbic system: (3) to determine the role of ss-arrestin in the effects of CB1R agonists and antagonists in behavioral assays ..
  4. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    Larry W Swanson; Fiscal Year: 2012
    ..The proposed research is designed to clarify very poorly understood neural circuits that mediate normal ingestive, defensive, reproductive, and sleep/wake behaviors;understanding their pathology will follow. ..
  5. Susan M Rivera; Fiscal Year: 2016
    ..In the first 5 years of this program of research ("Limbic System Function in Carriers of the Fragile X Premutation"), alongside other collaborative studies at our center, we ..
  6. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2013
    ..Zebrafish will be exposed to cocaine during the major periods of cortical (pallium) and limbic system (dorsomedial and dorsolateral telencephalon) development, synchronized with either the nighttime or daytime ..
  7. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
    ..While evidence points to altered communication between the limbic system and prefrontal cortex, confirmatory neuroimaging is lacking...
  8. Assessing the Influence of Oxytocin on Postpartum Depression Using Brain Imaging
    Julia R Heiman; Fiscal Year: 2010
    ..in women outside of the postpartum period have shown that depressed women exhibit altered prefrontal-limbic system neural activation patterns and increased reactivity to negative stimuli (Liberzon &Martis, 2006;Siegle et ..
  9. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
    ..While evidence points to altered communication between the limbic system and prefrontal cortex, confirmatory neuroimaging is lacking...
  10. Gene-environment interaction: the brain CRF system in alcohol preferring msP rats
    Marisa Roberto; Fiscal Year: 2013
    ..genetic polymorphism of the Corticotropin-Releasing Factor 1 Receptor (CRF1R) promoter, CRF1R density in the limbic system, and are highly sensitive to stress and stress-induced alcohol seeking, to provide information on the basic ..
  11. Effects of Psychopathology on Prefrontal Cortical Functioning During Goal-Directe
    Sharon L Thompson Schill; Fiscal Year: 2010
    ..attentional disturbances, and impulsivity) and a certain physiological profile as characterized by PFC-limbic system abnormalities...
  12. William R Lovallo; Fiscal Year: 2016
    ..These systems have an impact on functioning of the limbic system and prefrontal cortex, and in turn may provide insights into underlying alterations in motivation-related ..
  13. Beyond allergy: Mast cells mediate brain-behavior-immune interactions.
    Katherine M Nautiyal; Fiscal Year: 2010
    ..The likely site of mast cell impact on the limbic system is the hippocampus...
  14. Chemical Profiles of Brain Synapses at Ages Vulnerable to Activity-Based Anorexia
    Nicole C Barbarich-Marsteller; Fiscal Year: 2011
    ..is to test a novel hypothesis - namely, that females entering puberty are more vulnerable to AN because the limbic system of female brains at this stage in development express more of a particular type of neurotransmitter receptor ..
  15. A novel genetic and electrophysiological approach to study hippocampal neurons
    Tarik F Haydar; Fiscal Year: 2009
    The hippocampus, part of the limbic system, mediates learning and memory and is implicated in epilepsy...
  16. Subcortical control of neocortical slowing during focal hippocampal seizures
    JOSHUA ETHAN MOTELOW; Fiscal Year: 2012
    ..It is unknown how a focal seizure in the limbic system (including the hippocampus) creates ictal slowing in the neocortex and impaired consciousness...
  17. Adult neurobiology following adolescent drinking
    Ryan Peter Vetreno; Fiscal Year: 2013
    ..ethanol (AIE) will persistently alter both cellular and morphological maturation of th frontal cortex and limbic system, which will culminate in altered adult cognitive and emotive function...
  18. Dopamine Signaling Mechanisms of Traumatic Brain Injury
    C Edward Dixon; Fiscal Year: 2013
    ..impairments, are the most common persistent disability after TBI, resulting from disruptions in the striatum, limbic system, and frontal cortex...
  19. Serotonin-limbic system interactions that mediate anxiety
    Sheryl G Beck; Fiscal Year: 2013
    ..Unfortunately, the development of raphe-limbic system circuitry is not well understood...
  20. C57BI/6 Mouse Lines Expressing CRE-Recombinase in the Nervous System
    Ulrich Mueller; Fiscal Year: 2010
    ..for the neuroscience community, covering sensory biology and pain, CMS and stem cell development, the limbic system, and learning and memory...
  21. LATHAM FINK; Fiscal Year: 2015
    ..The neural systems supporting impulsive action include limbic system regulators of reward and motivation as well as cortical structures that exert inhibitory control, such as the ..
  22. The neuronal basis of cannabis-induced developmental deficits in the CNS
    Yasmin L Hurd; Fiscal Year: 2012
    ..We have previously found that CB1 cannabinoid receptors are selectively localized to the limbic system of the human embryo as early as week 14 of gestation, endocannabinoids and phytocannabinoids are instructive ..
  23. Role of the midline thalamus in arousal, attention and cognition
    ROBERT PAUL VERTES; Fiscal Year: 2013
    ..of the forebrain that participate in emotional and cognitive behavior which collectively constitute the limbic system. Two prominent distribution sites of the nucleus reuniens (RE) of the midline thalamus are the hippocampus and ..
  24. William J McBride; Fiscal Year: 2016
    ..The overall hypothesis to be tested is that responsiveness of the limbic system to the reinforcing, stimulating effects of ethanol (EtOH) contributes toward the initiation of alcohol ..
  25. Preliminary Clinical Trial of New Therapy for Patients with Severe Tinnitus
    RUTH QUILLIAN WOLEVER; Fiscal Year: 2012
    ..Specifically, processing by the limbic system and autonomic nervous system is apparently abnormal in patients with increased levels of cortical arousal and ..
  26. Post-Traumatic Stress Disorder and Alcohol Dependence
    Nicholas W Gilpin; Fiscal Year: 2013
    ..Because PTSD patients and alcoholics exhibit similar patterns of neural dysregulation in the limbic system, it is hypothesized that the amygdala and BNST serve as a neural interface for overlapping/additive effects of ..
  27. In Vivo Detection of Neuronal Activity
    Russell E Jacobs; Fiscal Year: 2010
    ..In this proposal we will: 1. Map normal neuronal pathways associated with the limbic system building on our Phase IR21 successes in combining T2 weighted, MEMRI, and DTI techniques...
  28. Manoj K Patel; Fiscal Year: 2016
    ..in the expression and physiology of Na channels that make neurons more excitable are found broadly in the limbic system seizure onset zone...
  29. Neuroscience Training at University of Connecticut Health Center
    ELIZABETH A EIPPER; Fiscal Year: 2010
    ..and signal transduction processes as well as the development, function and repair of the auditory system, limbic system, olfaction and taste, and auditory psychophysics...
  30. Assessing the development of hippocampus-amygdala interactions during emotional l
    Michael A Burman; Fiscal Year: 2012
    ..best understood as requiring an interaction among semi-independent neural circuits focused around a variety of limbic system structures, including the hippocampus, amygdala and limbic-associated regions of cortex...
  31. Roles for gliotransmisssion in seizure-related disorders
    Philip G Haydon; Fiscal Year: 2010
    ..is followed by a latent period of epileptogenesis during which there is a delayed death of neurons in the limbic system and cellular re-organizations that lead to the acquisition of spontaneous seizures (epilepsy)...
  32. Functional reorganization of limbic circuitry after TBI
    M Grady; Fiscal Year: 2009
    ..This proposal investigates how the ability to learn and recall information recovers. The limbic system plays a prominent role in memory formation, consolidation, and recall...
  33. Ivan Soltesz; Fiscal Year: 2014
    ..the activity of a low number of unique neurons that may be primarily responsible to triggering seizures in the limbic system. Our recent large-scale computational modeling studies have shown that rare, abnormal, super- connected, hub-..
  34. Effects of an angiotensin ll antagonist in a rat model of insomnia
    Georgina Cano; Fiscal Year: 2013
    ..Thus, during insomnia, the limbic system (involved in emotional processing) becomes activated and, in turn, activates part of the arousal system, which ..
  35. Istvan Mody; Fiscal Year: 2016
    ..of epilepsies, Huntington's disease (HD), Tourette[unreadable]s syndrome (TS) and other disorders of the limbic system and striatum...
  36. Effects of Cortisol Suppression on Fear-Potentiated Startle in Trauma &PTSD
    Tanja Jovanovic; Fiscal Year: 2012
    ..PTSD is marked by impaired cortical control of the limbic system, specifically the amygdala and hippocampus...
  37. Organization and Function of the Asymmetric Habenular Nuclei
    TAGIDE NOELIA DECARVALHO; Fiscal Year: 2013
    ..by applicant): The habenular nuclei are part of an evolutionarily conserved conduction pathway from the limbic system to the midbrain...
  38. Donald A Wilson; Fiscal Year: 2016
    ..olfactory cortex (receives direct input from the olfactory bulb) and is a major component of the temporal lobe/limbic system memory circuitry as the primary afferent to the hippocampal formation...
  39. Functional Neural Connectivity During Social Bonding in Voles
    Robert C Liu; Fiscal Year: 2013
    ..The objective here is to use chronic electrode implants in specific limbic system sites known to be modulated by oxytocin to determine the normal functional neural connectivity between these ..
  40. The Developmental Origins of Cerebral Cortical Expansion in Evolution &Disorder
    Christine J Charvet; Fiscal Year: 2013
    ..determine how evolution altered development to endow primates with an expanded cerebral cortex and a reduced limbic system (e.g., the olfactory bulb, septum, amygdala) compared with other mammals (e.g. rodents)...
  41. Avram J Holmes; Fiscal Year: 2016
    ..The proposed project, associated training, and mentorship will form the foundation of Dr. Holmes'independent research program, which will have anxiety and affective disorders as a core clinical focus. ..
  42. New Drugs for Stress-related Affective Illness
    Michael Brownstein; Fiscal Year: 2013
    ..V1a and V1b receptors in regions involved in the control of social behaviors and HPA axis regulation (V1a in limbic system;V1b in limbic system and anterior pituitary)...
  43. Neuroimaging correlates of impaired fear inhibition in PTSD
    Tanja Jovanovic; Fiscal Year: 2013
    ..PTSD is marked by impaired cortical control of the limbic system, specifically the amygdala and hippocampus...
  44. Synaptic plasticity, EtOH and backpropagating action potentials in NAcc
    Gilles E Martin; Fiscal Year: 2010
    ..To date, acute and chronic alcohol effects on LTP have been examined in structures of the limbic system (hippocampus, amygdala) and in the cortex...
  45. Neurocircuitry Plasticity After Cocaine Seeking
    BRIAN ROBERT LEE; Fiscal Year: 2012
    ..Within the limbic system, three major glutamatergic afferents that synapse onto NAc neurons originate from the prefrontal cortex (PFC), ..
  46. Howard L Fields; Fiscal Year: 2015
    ..The data provided by these studies will provide critical information for the development of circuit based models of limbic system function.
  47. JEFFREY STEVEN TAUBE; Fiscal Year: 2015
    ..patients and patients with Alzheimer's disease, a disease often associated with marked pathology in limbic system structures, to experience spatial disorientation to the extent that constant supervision is required...
  48. Xin Yun Lu; Fiscal Year: 2016
    ..These studies will generate novel insights into molecular and cellular mechanisms into leptin action in the limbic system and lead to the development of novel therapies for depression.
  49. Jordan W Smoller; Fiscal Year: 2016
    ..resource (the MGH Genomic Superstruct Project, GSP) we have recently identified a neural measure of limbic system integrity (amygdala enlargement and medial prefrontal cortical [mPFC] thinning) that is robustly associated ..
  50. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..a promoter that has been found to consistently drive the expression of a bacterial lacZ reporter gene in the limbic system of brain, establishment of new transgenic mouse lines will allow assessment of the effects of individually ..
  51. Delta-Notch Signaling by Intermediate Neuronal Progenitors: Live Imaging
    Robert F Hevner; Fiscal Year: 2010
    ..of the brain, such as social interactions and communication, and together with subcortical areas of the limbic system, regulate complex emotional and motivated behaviors...
  52. Neuroimaging Acupuncture Effects on Human Brain Activity
    Bruce R Rosen; Fiscal Year: 2010
    ..We hypothesize that the limbic system and default mode network (DMN) constitute major pathways of acupuncture action...
  53. William J McBride; Fiscal Year: 2016
    ..hypothesis is that increased activities of dopamine (DA) and glutamate (Glu) pathways within the meso-cortico-limbic system underlie cue-induced EtOH-seeking behavior and the activities of these pathways are further enhanced with ..
  54. Melatonin Receptors as Therapeutic Targets in Primates
    Margarita Dubocovich; Fiscal Year: 2006
    ..the distribution of melatonin receptors [MT1 (formerly Mel1a), MT2 (formerly Mel1b)] in the circadian and limbic system of a diurnal non-human primate...
  55. Joshua G Corbin; Fiscal Year: 2016
    ..Collectively these nuclei regulate major aspects of limbic system function...
  56. Douglas A Coulter; Fiscal Year: 2016
    ..The dentate gyrus also regulates pathological activation of the limbic system. This function, when compromised, may contribute to epilepsy development...
  57. A Mature Brain Architecture Knowledge Management System
    Larry W Swanson; Fiscal Year: 2012
    ..systems neuroscience research in the lab on the fundamental structural and chemical organization of limbic system circuits that control the basic drives and emotions, along with learning and memory...
  58. BACE1-NEUREGULIN-ErbB4 SIGNALING IN OLFACTORY MODELS OF PSYCHOSIS
    Vassilis E Koliatsos; Fiscal Year: 2010
    ..In this application, we combine our traditional strengths in neural plasticity of the olfactory limbic system and in transgenic animal models and propose that at least a portion of psychotic symptoms may be modeled on ..
  59. Ellen Peck; Fiscal Year: 2014
    ..It is part of the limbic system, and is known to be involved in assigning value, both positive and negative, to stimuli;additionally, it has ..
  60. SYNAPTIC ORGANIZATION OF BASAL FOREBRAIN PROJECTIONS
    David Finch; Fiscal Year: 1991
    ..and pharmacological analyses of the synaptic organization of pathways from the rat basal forebrain to the limbic system and thalamus, and reciprocal projections from the limbic system to the basal forebrain...
  61. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  62. LIMBIC SENSITIVITY IN COCAINE ADDICTION
    Bryon Adinoff; Fiscal Year: 2005
    The limbic system is an integrated brain area involved in the regulation of reward, motivation, emotional expression, and memory. These regions are considered critical to the development and persistence of addiction...
  63. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract) : Synaptic loss and neurodegeneration in the neocortex and limbic system in patients with Alzheimer's disease (AD) results in characteristic cognitive alterations...
  64. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    LARRY SWANSON; Fiscal Year: 2005
    ..abstract_text> ..
  65. Forebrain Response to Sapid NaCI During Salt Appetite
    Samantha Dayawansa; Fiscal Year: 2009
    ..more than others due to the innate reward mechanism in the central nervous system which is driven by limbic system mediated motivation...
  66. REGULATION OF LIMBIC EXCITABILITY
    Cheolsu Shin; Fiscal Year: 1992
    The basal ganglia and limbic system are considered to be anatomically and functionally separate entities, dealing with motor activity and emotion-motivation respectively...
  67. EARLY ABUSE AND CORTICOLIMBIC DEVELOPMENT
    Martin Teicher; Fiscal Year: 1999
    ..early traumatic experience, in the form of childhood abuse, affects the development of the cerebral cortex and limbic system. This hypothesis endeavors to explain the psychiatric sequela of childhood traumatic experience using an ..
  68. DRUG ADDICTION: DUAL 5-HT INNERVATION OF LIMBIC SYSTEM
    MARK MOLLIVER; Fiscal Year: 2003
    ..abstract_text> ..