pancreas transplantation

Summary

Summary: The transference of a pancreas from one human or animal to another.

Top Publications

  1. ncbi Cross-sectional assessment of the effect of kidney and kidney-pancreas transplantation on resting left ventricular energy metabolism in type 1 diabetic-uremic patients: a phosphorous-31 magnetic resonance spectroscopy study
    Gianluca Perseghin
    Division of Internal Medicine Section of Nutrition Metabolism, Universita Vita e Salute San Raffaele, Milan, Italy
    J Am Coll Cardiol 46:1085-92. 2005
  2. pmc Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation
    Elsa Laughlin
    Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA
    Clin Immunol 128:23-30. 2008
  3. doi Pancreas transplantation
    Steve A White
    Department of Hepatopancreatobiliary and Transplantation Surgery, Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, UK
    Lancet 373:1808-17. 2009
  4. doi Islet versus pancreas transplantation in type 1 diabetes: competitive or complementary?
    Barbara Ludwig
    Department of Medicine III, University Hospital Carl Gustav Carus, Fetscherstr 74, 01307, Dresden, Germany
    Curr Diab Rep 10:506-11. 2010
  5. pmc Results of pancreas transplantation alone with special attention to native kidney function and proteinuria in type 1 diabetes patients
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Rev Diabet Stud 8:259-67. 2011
  6. pmc Near normalization of metabolic and functional features of the central nervous system in type 1 diabetic patients with end-stage renal disease after kidney-pancreas transplantation
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham andWomen s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:367-74. 2012
  7. pmc Recovery of endocrine function after islet and pancreas transplantation
    Michael R Rickels
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Institute for Diabetes, Obesity, and Metabolism, 12 134 Translational Research Center, Philadelphia, PA 19104, USA
    Curr Diab Rep 12:587-96. 2012
  8. doi Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation
    Manuel Maglione
    Oxford Transplant Centre, Oxford, UK
    Curr Opin Organ Transplant 18:83-8. 2013
  9. ncbi A novel technique for heterotopic vascularized pancreas transplantation in mice to assess ischemia reperfusion injury and graft pancreatitis
    Manuel Maglione
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Innsbruck Medical University, Innsbruck, Austria
    Surgery 141:682-9. 2007
  10. pmc Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model
    M Maglione
    Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Center of Operative Medicine, Innsbruck Medical University, Austria
    Am J Transplant 10:2231-40. 2010

Research Grants

  1. TRIAL OF ANTI-TNF ALPHA IN ISLET TRANSPLANTATION
    Andrew Shapiro; Fiscal Year: 2002
  2. Corneal Confocal Microscopy: a non-invasive surrogate for diabetic neuropathy
    RAYAZ AHMED MALIK; Fiscal Year: 2012
  3. David H Sachs; Fiscal Year: 2016
  4. New Solutions to Improve Islet Recovery after Machine Preservation of Pancreas
    Michael Taylor; Fiscal Year: 2009
  5. Ashok K Saluja; Fiscal Year: 2014
  6. PETER CAWOOD BUTLER; Fiscal Year: 2016
  7. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
  8. Strategy to Cure Type 1 Diabetes
    Zhiguang Guo; Fiscal Year: 2003
  9. Genetic Markers of Acute Pancreas Allograft Rejection
    Ann Cashion; Fiscal Year: 2002
  10. STUDIES OF PANCREAS TRANSPLANTATION IN DIABETES
    MARSHALL ORLOFF; Fiscal Year: 1980

Detail Information

Publications323 found, 100 shown here

  1. ncbi Cross-sectional assessment of the effect of kidney and kidney-pancreas transplantation on resting left ventricular energy metabolism in type 1 diabetic-uremic patients: a phosphorous-31 magnetic resonance spectroscopy study
    Gianluca Perseghin
    Division of Internal Medicine Section of Nutrition Metabolism, Universita Vita e Salute San Raffaele, Milan, Italy
    J Am Coll Cardiol 46:1085-92. 2005
    ..affecting type 1 diabetic-uremic patients was associated with abnormal heart high-energy phosphates (HEPs) and to ascertain whether these alterations were also present in recipients of kidney or kidney-pancreas transplantation.
  2. pmc Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation
    Elsa Laughlin
    Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA
    Clin Immunol 128:23-30. 2008
    ..specific for the diabetes-associated autoantigen GAD65 were analyzed using peripheral blood samples after pancreas transplantation in subjects with T1D with clinical evidence of recurrent autoimmune diabetes...
  3. doi Pancreas transplantation
    Steve A White
    Department of Hepatopancreatobiliary and Transplantation Surgery, Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, UK
    Lancet 373:1808-17. 2009
    Since the introduction of pancreas transplantation more than 40 years ago, efforts to develop more minimally invasive techniques for endocrine replacement therapy have been in progress, yet this surgical procedure still remains the ..
  4. doi Islet versus pancreas transplantation in type 1 diabetes: competitive or complementary?
    Barbara Ludwig
    Department of Medicine III, University Hospital Carl Gustav Carus, Fetscherstr 74, 01307, Dresden, Germany
    Curr Diab Rep 10:506-11. 2010
    ....
  5. pmc Results of pancreas transplantation alone with special attention to native kidney function and proteinuria in type 1 diabetes patients
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Rev Diabet Stud 8:259-67. 2011
    We report on our single-center experience with pancreas transplantation alone (PTA) in 71 patients with type 1 diabetes, and a 4-year follow-up. Portal insulin delivery was used in 73...
  6. pmc Near normalization of metabolic and functional features of the central nervous system in type 1 diabetic patients with end-stage renal disease after kidney-pancreas transplantation
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham andWomen s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:367-74. 2012
    ..Kidney-pancreas (KP), but not kidney alone (KD), transplantation is associated with sustained normoglycemia, improvement in quality of life, and reduction of morbidity/mortality in diabetic patients with end-stage renal disease (ESRD)...
  7. pmc Recovery of endocrine function after islet and pancreas transplantation
    Michael R Rickels
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Institute for Diabetes, Obesity, and Metabolism, 12 134 Translational Research Center, Philadelphia, PA 19104, USA
    Curr Diab Rep 12:587-96. 2012
    ..pancreas, and since not all pancreata are technically suitable for whole organ transplantation, islet and pancreas transplantation are evolving as complementary approaches for the recovery of endocrine function in patients with the most ..
  8. doi Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation
    Manuel Maglione
    Oxford Transplant Centre, Oxford, UK
    Curr Opin Organ Transplant 18:83-8. 2013
    b>Pancreas transplantation is still hampered by a high incidence of early graft loss, and organ quality concerns result in high nonrecovery/discard rates...
  9. ncbi A novel technique for heterotopic vascularized pancreas transplantation in mice to assess ischemia reperfusion injury and graft pancreatitis
    Manuel Maglione
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Innsbruck Medical University, Innsbruck, Austria
    Surgery 141:682-9. 2007
    Although various suture techniques for murine pancreas transplantation have been described, severe limitations have limited their widespread use...
  10. pmc Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model
    M Maglione
    Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Center of Operative Medicine, Innsbruck Medical University, Austria
    Am J Transplant 10:2231-40. 2010
    ..injury (IRI) by H4B-substitution are missing we investigated its therapeutic potential in a murine pancreas transplantation model using different treatment regimens...
  11. ncbi Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution for organ preservation in clinical pancreas transplantation
    Jonathan A Fridell
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Transplantation 77:1304-6. 2004
    ..This study assesses the efficacy of histidine-tryptophan-ketoglutarate (HTK) compared with UW in pancreas transplantation.
  12. ncbi Reduction of ischemia/reperfusion injury by antithrombin III after experimental pancreas transplantation
    Thilo Hackert
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Am J Surg 189:92-7. 2005
    Graft pancreatitis is a major complication after pancreas transplantation. Antithrombin III (AT III) is an anticoagulatory and anti-inflammatory substance...
  13. doi Evolution of β-Cell Replacement Therapy in Diabetes Mellitus: Pancreas Transplantation
    Cyrus Jahansouz
    University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Diabetes Technol Ther 13:395-418. 2011
    ..In this review, the historical evolution, current status, graft efficacy, benefits, and complications of pancreas transplantation are explored.
  14. ncbi Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice
    M Castaing
    INSERM U457, , Paris, France
    Diabetologia 44:2066-76. 2001
    ..Transplantation of human embryonic pancreas into NOD/scid mice is a useful model for understanding the development of the human pancreas during prenatal life...
  15. ncbi Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques
    S A Rogers
    George M O Brien Center for Kidney Disease Research, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Xenotransplantation 14:591-602. 2007
    ....
  16. pmc Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model
    Gil Hecht
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 106:8659-64. 2009
    ..Its long-term proliferative capacity, its revascularization by host endothelium, and its reduced immunogenicity, strongly suggest that this approach could offer an attractive replacement therapy for diabetes...
  17. ncbi Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation
    M Maglione
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Austria
    Am J Transplant 6:1551-9. 2006
    ..an essential cofactor for nitric oxide synthases, on ischemia-reperfusion injury (IRI) following murine pancreas transplantation. Pancreatic grafts were exposed to prolonged cold ischemia times (CIT) and different treatment regimens: ..
  18. doi Soluble total human leukocyte antigen class I and human leukocyte antigen-G molecules in kidney and kidney/pancreas transplantation
    Vera Rebmann
    Institut fur Transfusionsmedizin, Universitatsklinikum Essen, Essen, Germany
    Hum Immunol 70:995-9. 2009
    ..Thus high levels of sHLA-G but not of sHLA-I seem to contribute to better graft acceptance after kidney or kidney/pancreas transplantation.
  19. pmc 2011 update on pancreas transplantation: comprehensive trend analysis of 25,000 cases followed up over the course of twenty-four years at the International Pancreas Transplant Registry (IPTR)
    Angelika C Gruessner
    Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin, Tucson AZ 85724, USA
    Rev Diabet Stud 8:6-16. 2011
    ..This study aimed to analyze the outcome of pancreas and pancreas-kidney transplantations based on the comprehensive follow-up data reported to the International Pancreas Transplant Registry (IPTR)...
  20. doi Pancreas transplantation in the United States: a review
    Angelika C Gruessner
    Department of Surgery, University of Arizona, Tucson, Arizona 85724, USA
    Curr Opin Organ Transplant 15:93-101. 2010
    The goal of pancreas transplantation is to restore normoglycemia in patients with labile diabetes...
  21. ncbi Development of human fetal pancreas after transplantation into SCID mice
    Z Si
    Pancreas Transplant Unit, Prince of Wales Hospital, Sydney, NSW, Australia
    Cells Tissues Organs 168:147-57. 2001
    ..We hypothesize that following the transplantation of human fetal pancreatic tissue, exocrine cells mostly transdifferentiate into duct cells and these eventually develop into endocrine cells, in particular beta cells...
  22. ncbi The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism
    A Carpentier
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes 50:1402-13. 2001
    Combined kidney-pancreas transplantation (KPT) with anastomosis of the pancreatic vein to the systemic circulation (KPT-S) or to the portal circulation (KPT-P) provides a human model in which the chronic effects of portal versus systemic ..
  23. ncbi Restored hypoglycemic counterregulation is stable in successful pancreas transplant recipients for up to 19 years after transplantation
    B W Paty
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Transplantation 72:1103-7. 2001
    BACKGROUND: Pancreas transplantation has been shown to fully restore glucagon response and partially restore epinephrine response to hypoglycemia during the first few years after transplantation in patients with type 1 diabetes...
  24. ncbi Treatment and outcome of pancreatic venous graft thrombosis after kidney--pancreas transplantation
    R Gilabert
    Imaging Diagnosis Center, Department of Surgery and Renal Transplant Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Br J Surg 89:355-60. 2002
    ..Duplex Doppler ultrasonography is the primary imaging technique for monitoring vascular patency after pancreas transplantation. This study reports the results of rescue treatments for pancreas graft thrombosis after simultaneous ..
  25. ncbi Canine pancreas allotransplantation with enteric drainage
    Yi Ming Shyr
    Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Zhonghua Yi Xue Za Zhi (Taipei) 65:483-8. 2002
    Before embarking on a clinical human pancreas transplantation program we sought a canine animal model with enteric drainage to refine our technical skills, to evaluate the surgical risks and to study the rejection pictures under modern ..
  26. ncbi Spectral analysis of heart rate variation following simultaneous pancreas and kidney transplantation
    P Boucek
    Diabetes and Transplant Centers, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Transplant Proc 35:1494-8. 2003
    ..Thus the results of a power spectral analysis of HRV failed to show improvement following SPK. This examination adds little positive information to that obtained from standard autonomic function tests...
  27. ncbi Pancreas transplant alone determines early improvement of cardiovascular risk factors and cardiac function in type 1 diabetic patients
    Alberto Coppelli
    Department of Endocrinology and Metabolism, Metabolic Unit, Cisanello Hospital Pisa University, Pisa, Italy
    Transplantation 76:974-6. 2003
    ..The effects of pancreas transplant alone (PTA) on cardiovascular risk factors (CRF) and cardiac function in type 1 diabetes mellitus (T1DM) patients are still unsettled...
  28. ncbi Intraperitoneal transplantation of pancreatic anlagen
    Sharon A Rogers
    Renal Division, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    ASAIO J 49:527-32. 2003
    ..Implantation of the embryonic pancreas, a "cellular" transplant, is followed by selective differentiation of islet compared with acinar components...
  29. ncbi Isolated pancreas transplantation for type 1 diabetes: a doctor's dilemma
    David M Nathan
    Diabetes Center and General Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JAMA 290:2861-3. 2003
  30. ncbi Pancreas graft thrombosis: is there a role for trypsin
    S Benz
    Department of Visceral Surgery, University of Freiburg, Germany
    Pancreas 28:75-9. 2004
    Thrombosis of the pancreas graft is the main cause of early graft loss in pancreas transplantation. We investigated whether hypercoagulability develops locally in the pancreas and contributes to thrombosis formation because of ischemia or ..
  31. ncbi The impact of donor obesity on outcomes after cadaver pancreas transplants
    Abhinav Humar
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Transplant 4:605-10. 2004
    ..Technically successful transplants using obese donors results in good graft function at 1 and 3 years posttransplant...
  32. ncbi Spectrum of imaging findings after pancreas transplantation with enteric exocrine drainage: Part 2, posttransplantation complications
    Martin C Freund
    Department of Radiology, Leopold Franzens University, Anichstrasse 35, Innsbruck A 6020, Austria
    AJR Am J Roentgenol 182:919-25. 2004
  33. ncbi Pancreas transplants: experience with 232 percutaneous US-guided biopsy procedures in 88 patients
    Thomas D Atwell
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Radiology 231:845-9. 2004
    ..To retrospectively assess the authors' experience with percutaneous ultrasonographic (US)-guided biopsy of pancreas transplants...
  34. ncbi Does treatment of cadaveric organ donors with desmopressin increase the likelihood of pancreas graft thrombosis? Results of a preliminary study
    R G Marques
    Division of Transplant Surgery, Medical University of South Carolina, Charleston, 29425, USA
    Transplant Proc 36:1048-9. 2004
    ..The aim of this study was too evaluate the effect of DDAVP on the incidence of PG thrombosis in clinical pancreas transplantation. A retrospective review of simultaneous kidney-pancreas transplant (SKPT) entered in the Scientific ..
  35. ncbi Long-term survival after kidney and kidney-pancreas transplantation in diabetic patients
    E Orsenigo
    Department of Surgery, Vita e Salute University, San Raffaele Scientific Institute, Milan, Italy
    Transplant Proc 36:1072-5. 2004
    ..To investigate the influence of diabetes mellitus on patient and graft survival among renal versus renal-pancreatic recipients...
  36. ncbi Hypercoagulable state associated with kidney-pancreas transplantation. Thromboelastogram-directed anti-coagulation and implications for future therapy
    George W Burke
    Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, FL 33101, USA
    Clin Transplant 18:423-8. 2004
    ..This has led us to perform intra-operative thromboelastograms (TEG's) to evaluate the patient's current coagulation status...
  37. ncbi Acceptance criteria of pancreas grafts: how do surgeons decide in Europe?
    C Wullstein
    Department of General and Vascular Surgery, Goethe University, Frankfurt, Germany
    Transplant Proc 37:1259-61. 2005
    Some donor factors, such as age, cause of death, and obesity, affect the outcomes of pancreas transplantation. Donors with a high-risk profile are usually not declined for pancreas donation...
  38. ncbi Posttransplant lymphoproliferative disorder in pancreas transplantation: a single-center experience
    Steven Paraskevas
    Department of Surgery, University of Minnesota, Minneapolis, 55455, USA
    Transplantation 80:613-22. 2005
    ..Posttransplant lymphoproliferative disorder (PTLD) is a rare, serious complication of transplantation. The characteristics and associations of this disease in pancreas recipients have not been extensively studied...
  39. ncbi An evidence-based analysis of simultaneous pancreas-kidney and pancreas transplantation alone
    Nicolas Demartines
    Department of Visceral and Transplant Surgery, University Hospital, Zurich, Switzerland
    Am J Transplant 5:2688-97. 2005
    While pancreas transplantation has evolved within two decades from a frustrating and poorly-accepted therapeutic option to a highly successful procedure, the respective benefits of the successive surgical and immunosuppressive ..
  40. ncbi Simultaneous liver and pancreas transplantation in patients with cystic fibrosis
    J A Fridell
    Department of Surgery, Indiana University, 550 N University Boulevard 4258, Indianapolis, IN 46202, USA
    Transplant Proc 37:3567-9. 2005
    ..Liver transplantation is the treatment of choice for cirrhosis in this setting, but the addition of an isolated simultaneous pancreas transplant in patients with CFRD has not been reported...
  41. ncbi Severe depletion of intraepidermal nerve fibers in skin biopsies of pancreas transplant recipients
    P Boucek
    Diabetes Center, Institute for Clinical and Experimental Medicine, Videnska 1958 9, 140 21 Prague 4, Czech Republic
    Transplant Proc 37:3574-5. 2005
    ..We assessed IENF counts as a database for long-term follow-up of diabetic neuropathy...
  42. ncbi Pancreas and islet transplantation in type 1 diabetes
    R Paul Robertson
    Diabetes Care 29:935. 2006
  43. ncbi Influence of pancreas transplantation alone on native renal function
    T Genzini
    HEPATO Hepatology and Organ Transplantation, Albert Einstein Hospital, Sao Paulo, Brazil
    Transplant Proc 38:1939-40. 2006
    b>Pancreas transplantation alone (PTA) has become an accepted treatment of nonuremic diabetic patients, when the risks of secondary complications of diabetes mellitus are greater than those of the surgical procedure and the posttransplant ..
  44. ncbi Kidney and pancreas transplantation in the United States, 1996-2005
    K A Andreoni
    Surgery, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA
    Am J Transplant 7:1359-75. 2007
    Kidney and pancreas transplantation in 2005 improved in quantity and outcome quality, despite the increasing average age of kidney graft recipients, with 56% aged 50 or older...
  45. doi Present status of pancreas transplantation in Japan--donation predominantly from marginal donors and modified surgical technique: report of Japan pancreas transplantation registry
    M Ishibashi
    Department of Urology, Nara Medical University Hospital, Nara, Japan
    Transplant Proc 40:486-90. 2008
    ..The aim of this study was to show the effectiveness of pancreas transplantation (PTx) by analyzing the outcomes even under poor donor conditions...
  46. doi Simultaneous bilateral lung and pancreas transplantation in recipient with cystic fibrosis
    J A Fridell
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Transplant Proc 40:494-7. 2008
    ..In this report we have reviewed our experience with a simultaneous lung and pancreas transplantation in a patient with CF.
  47. doi The clinical impact of islet transplantation
    P Fiorina
    Transplantation Research Center, Children s Hospital Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Am J Transplant 8:1990-7. 2008
    ..Once clinical islet transplantation has been successfully established, this treatment could even be offered to diabetic patients long before the onset of diabetic complications...
  48. doi Pancreas transplants
    J Chandra
    Department of Radiology, Churchill Hospital, Headington, Oxford, UK
    Clin Radiol 64:714-23. 2009
    Cadaveric, whole pancreas transplantation has proved an effective therapy in the treatment of long-standing type 1 diabetes mellitus and is capable of achieving an insulin-independent eugyclaemic state...
  49. doi A long-term prevention of diabetic nephropathy in a patient with type 1 diabetes after simultaneous pancreas and kidney transplantation
    Izumi Nyumura
    Department of Medicine, Diabetes Center, Women s Medical University School of Medicine, Tokyo, Japan
    Clin Transplant 23:54-7. 2009
    ..which revealed no recurrence of diabetic nephropathy, suggesting that long-term normalization of glycemic control achieved by successful pancreas transplantation can prevent recurrence of diabetic nephropathy in the kidney allograft.
  50. doi Pancreas allograft thrombosis following intravenous immunoglobulin administration to treat parvovirus B19 infection
    A S R Muthusamy
    Oxford Transplant Centre, Churchill Hospital, Oxford, UK
    Transpl Infect Dis 11:463-6. 2009
    ..The potential role of hypercoagulability in graft thrombosis and the implications for immunoglobulin therapy in transplant patients with hypercoagulable states is discussed...
  51. doi Impact of pancreas transplantation on type 1 diabetes-related complications
    Chiara Gremizzi
    Transplant Unit, Department of Internal Medicine, Vita Salute San Raffaele University, Milano, Italy
    Curr Opin Organ Transplant 15:119-23. 2010
    ..insulin scheme treatment has been shown to reduce the incidence of diabetes-related complications, only pancreas transplantation has been shown to be able to alter them and in some cases to revert them...
  52. doi Pancreatic graft survival despite partial vascular graft thrombosis due to splenocephalic anastomoses
    C Margreiter
    Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Am J Transplant 10:846-51. 2010
    Thrombotic complications following pancreas transplantation are still the most common cause of nonimmunologic graft loss...
  53. pmc Risks and benefits of transplantation in the cure of type 1 diabetes: whole pancreas versus islet transplantation. A single center study
    Paola Maffi
    Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
    Rev Diabet Stud 8:44-50. 2011
    ..Great variability in terms of rate of success for both approaches is reported in the literature and it is difficult to compare the respective risks and benefits...
  54. doi Posttransplant donor-specific anti-HLA antibodies negatively impact pancreas transplantation outcome
    D Cantarovich
    Institut de Transplantation et de Recherche en Transplantation, Nantes University Hospital, Nantes, France
    Am J Transplant 11:2737-46. 2011
    ..5% vs. 11%; p < 0.01). Occurrence of posttransplant DSA was an independent risk factor for both pancreas and kidney survival (HR 3.2; p = 0.039) in diabetic transplant recipients...
  55. doi Thymoglobulin versus basiliximab induction therapy for simultaneous kidney-pancreas transplantation: impact on rejection, graft function, and long-term outcome
    Fateh Bazerbachi
    Department of Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Transplantation 92:1039-43. 2011
    Thymoglobulin (ATG) and basiliximab induction therapies are used by the majority of centers for pancreas transplantation today. Although both strategies have different mechanisms, there is a paucity of studies comparing them...
  56. doi Long-term outcome after pancreas transplantation
    Angelika C Gruessner
    College of Public Health, University of Arizona, 1295 N Martin Ave, Tucson, AZ 85724 5163, USA
    Curr Opin Organ Transplant 17:100-5. 2012
    b>Pancreas transplantation provides the only proven method to restore long-term normoglycemia in patients with insulin-dependent diabetes mellitus...
  57. doi Reversal of diabetic nephropathy: lessons from pancreas transplantation
    Paola Fioretto
    Department of Medicine, University of Padova Medical School, Padova, Italy
    J Nephrol 25:13-8. 2012
    b>Pancreas transplantation is the only therapeutic intervention able to achieve and maintain long-term euglycemia, without risks of hypoglycemia; this makes it possible to test the impact of normoglycemia in the different stages of diabetic ..
  58. doi Imaging of whole-organ pancreas transplants
    Fauzia Q Vandermeer
    Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201, USA
    Radiographics 32:411-35. 2012
    Whole pancreas transplantation is an established treatment for selected patients with diabetic nephropathy or poorly controlled diabetes. Surgical techniques vary and have evolved over the past 4 decades...
  59. doi Imaging of miscellaneous pancreatic pathology (trauma, transplant, infections, and deposition)
    Nagaraj Setty Holalkere
    Department of Radiology, Boston Medical Center, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA
    Radiol Clin North Am 50:515-28. 2012
    ....
  60. doi Why offered pancreases are refused in the allocation process-a descriptive study using routine data from eurotransplant
    Martin Loss
    Department of Surgery, University Hospital Regensburg, Regensburg, Germany
    Transplantation 95:1134-41. 2013
    ..The majority of pancreases, offered in allocation, are discarded. This pancreas underutilization is not well understood yet...
  61. ncbi The effect of whole organ pancreas transplantation and PIT on diabetic complications
    Timothy C Lee
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Diab Rep 6:323-7. 2006
    ..Currently, the only forms of beta-cell replacement are whole organ pancreas transplantation and pancreatic islet transplantation...
  62. ncbi Altered kidney graft high-energy phosphate metabolism in kidney-transplanted end-stage renal disease type 1 diabetic patients: a cross-sectional analysis of the effect of kidney alone and kidney-pancreas transplantation
    Paolo Fiorina
    Department of Medicine, San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy
    Diabetes Care 30:597-603. 2007
    ..The aim of this study was to ascertain the impact of kidney alone (KD) or combined kidney-pancreas (KP) transplantation on renal energy metabolism...
  63. ncbi Spectrum of histopathological changes in pancreas allograft biopsies and relationship to graft loss
    C B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Transplant Proc 39:2326-8. 2007
    ....
  64. doi Immediate retransplantation for pancreas allograft thrombosis
    E F Hollinger
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Transplant 9:740-5. 2009
    ..Immediate retransplantation following pancreatic graft thrombosis restores durable allograft function with outcomes comparable to first-time pancreas transplantation.
  65. doi Complications after pancreas transplantation
    Christoph Troppmann
    Department of Surgery, University of California, Davis, Sacramento, California 95817, USA
    Curr Opin Organ Transplant 15:112-8. 2010
    ..After more than three decades of progress, surgical-technical pancreas graft failure rates have decreased to approximately 8%. The most recent developments in this area are systematically reviewed in this article...
  66. ncbi In vivo imaging of human pancreatic microcirculation and pancreatic tissue injury in clinical pancreas transplantation
    Klaus D Schaser
    Department of Trauma and Reconstructive Surgery, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Berlin, Germany
    Am J Transplant 5:341-50. 2005
    Pancreatitis remains to be a major complication following clinical pancreas transplantation. We performed orthogonal polarized spectral (OPS) imaging for direct in vivo visualization and quantification of human pancreatic microcirculation ..
  67. ncbi Evaluation of vascular complications of pancreas transplantation with high-spatial-resolution contrast-enhanced MR angiography
    Klaus D Hagspiel
    Department of Radiology and Division of Transplant Surgery, University of Virginia Health System, PO Box 800170, 1215 Lee St, Charlottesville, VA 22908, USA
    Radiology 242:590-9. 2007
    ..To retrospectively evaluate high-spatial-resolution contrast material-enhanced three-dimensional (3D) magnetic resonance (MR) angiography for assessment of vascular complications of pancreas allografts...
  68. doi Evaluation of segmental pancreatic function using 11C-methionine positron emission tomography for safe operation of living donor pancreas transplantation
    K Otsuki
    Department of Surgery, National Chiba East Hospital, Chiba, Japan
    Transplant Proc 40:2562-4. 2008
    For the safe operation of living donor pancreas transplantation, we investigated the utility of 11C-methionine positron emission tomography (PET) to examine the function of the residual pancreatic head in patients with pancreatic disease ..
  69. ncbi Effect of nitric oxide in ischemia/reperfusion of the pancreas
    S Benz
    Department of Surgery, University of Freiburg, 79111 Freiburg, Germany
    J Surg Res 106:46-53. 2002
    Ischemia/reperfusion injury, and thus graft pancreatitis, remains a major problem in pancreas transplantation. Contradictory results about the role of nitric oxide (NO) in pancreatic ischemia/reperfusion have been reported; however, in ..
  70. ncbi Effects of organ preservation, ischemia time and caspase inhibition on apoptosis and microcirculation in rat pancreas transplantation
    Oliver Drognitz
    Department of General and Digestive Surgery, University of Freiburg, Freiburg, Germany
    Am J Transplant 4:1042-50. 2004
    ..examine the impact of ischemia-reperfusion (I/R) injury on microcirculation and apoptosis in experimental pancreas transplantation. Pancreatic grafts were subjected to different preservation solutions and cold ischemia times (CITs): ..
  71. ncbi Development of islet-like cell clusters after pancreas transplantation in the spontaneously diabetic Torri rat
    Gang Miao
    Department of Surgery E1, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Transplant 5:2360-7. 2005
    b>Pancreas transplantation (PTx) has evolved as a clinical therapy to achieve sustained euglycemia. However, it remains unclear if naive diseased islets of the pancreas benefit from the avoidance of glucose toxicity by PTx...
  72. ncbi Clopidogrel-associated acute migratory arthritis following kidney-pancreas transplantation
    A S R Muthusamy
    Oxford Transplant Centre, Churchill Hospital, Headington, Oxford, United Kingdom
    Int J Immunopathol Pharmacol 19:443-4. 2006
    ..A 34-year-old uremic type 1 male diabetic patient who underwent simultaneous kidney-pancreas transplantation was given clopidogrel as he was allergic to aspirin...
  73. pmc Selective unresponsiveness to beta cell autoantigens after induction immunosuppression in pancreas transplantation with anti-interleukin-2 receptor antibody versus anti-thymocyte globulin
    P van de Linde
    Department of Surgery, LUMC, Leiden, The Netherlands
    Clin Exp Immunol 149:56-62. 2007
    b>Pancreas transplantation in type 1 diabetes patients could result in (re)activation of allo- and autoreactive T lymphocytes...
  74. ncbi Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus
    Fu L Luan
    Internal Medicine, Division of Nephrology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Transplantation 84:541-4. 2007
    We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD)...
  75. ncbi Pancreas-kidney and pancreas transplantation for the treatment of diabetes mellitus
    Gerald S Lipshutz
    Kidney and Pancreas Transplant Program, Department of Surgery, 77 120 CHS, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Endocrinol Metab Clin North Am 36:1015-38; x. 2007
    ..Although its use is increasing, pancreas transplantation remains an uncommonly used therapeutic option that normalizes glucose levels and results in stabilization ..
  76. doi Advances in immunosuppression for pancreas transplantation
    Rajinder P Singh
    Department of General Surgery, Section of Transplantation, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Organ Transplant 13:79-84. 2008
    A review of current literature was performed to identify trends and evaluate outcomes with regard to clinical immunosuppression in pancreas transplantation.
  77. doi Portal and systemic venous drainage in pancreas and kidney-pancreas transplantation: early surgical complications and outcomes
    J Quintela
    Service of General Surgery, Hospital Juan Canalejo, A Coruna, Spain
    Transplant Proc 41:2460-2. 2009
    The objective of this study was to perform a retrospective analysis of the clinical evolution and surgical complications comparing pancreas transplantation with systemic-enteric (SE) drainage versus portal-enteric (PE) drainage.
  78. doi One thousand simultaneous pancreas-kidney transplants at a single center with 22-year follow-up
    Hans W Sollinger
    Division of Transplantation, University of Wisconsin, Madison, WI 53792, USA
    Ann Surg 250:618-30. 2009
    ..The purpose of this study is to report long-term outcomes of this procedure, and describe surgical and medical complications...
  79. doi Effects of pancreas transplantation on the prevention and reversal of diabetic nephropathy
    Paola Fioretto
    Department of Medical and Surgical Sciences, University of Padova Medical School, Padova, Italy
    Contrib Nephrol 170:237-46. 2011
    b>Pancreas transplantation (PTx) is the only available treatment which is able to restore normoglycemia without exposing patients to the risks of severe hypoglycemia, thus allowing testing the effects of very long-term euglycemia in ..
  80. ncbi Review of immunosuppressive usage in pancreas transplantation
    R J Stratta
    Department of Surgery, University of Tennessee Memphis 38163 2116, USA
    Clin Transplant 13:1-12. 1999
    ..According to registry data, rejection accounts for 32% of graft failures in the first year after pancreas transplantation. However, improvements are expected to continue with the evolution of treatment protocols...
  81. ncbi Outcomes in clinical pancreas transplantation with the two-layer cold storage method versus simple storage in University of Wisconsin solution
    K Hiraoka
    Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Science, Kobe, Japan
    Transplant Proc 34:2688-9. 2002
  82. ncbi Transplantation of embryonic organs - kidney and pancreas
    Marc R Hammerman
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Transplant 4:14-24. 2004
    ..Implantation of the embryonic pancreas, is followed by selective differentiation of islet as compared to acinar components. Here we review studies exploring the potential therapeutic use of embryonic kidney or pancreas transplantation.
  83. ncbi Pregnancy after kidney and kidney-pancreas transplantation under tacrolimus: a single center's experience
    Ashokkumar B Jain
    Thomas E Starzl Transplantation Institute, UPMC Montefiore, Pittsburgh, PA, USA
    Transplantation 77:897-902. 2004
    ..The aim of the present report is to examine the outcome of pregnancies under tacrolimus after kidney transplantation (KTx) and simultaneous kidney-pancreas transplantation (SPKTx).
  84. ncbi Intermittent capillary perfusion in rat pancreas grafts following short- and long-term preservation in University of Wisconsin solution
    Gerhard Preissler
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    Transpl Int 19:325-32. 2006
    In pancreas transplantation (PTx), ischemia/reperfusion-induced deterioration of graft-microcirculation is accompanied by alterations of intermittent capillary perfusion (IP; alternating cessation and resumption of capillary blood flow) ..
  85. ncbi Sirolimus improves early microcirculation, but impairs regeneration after pancreatic ischemia-reperfusion injury
    F Serr
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Am J Transplant 7:48-56. 2007
    Ischemia and reperfusion injury remains a relevant problem in clinical pancreas transplantation. We investigated the effect of sirolimus (SRL) in a rodent model of 90-min warm pancreatic ischemia...
  86. doi Kidney and pancreas transplantation in the United States, 1999-2008: the changing face of living donation
    D A Axelrod
    Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Am J Transplant 10:987-1002. 2010
    ..Many strategies have been adopted to reverse the decline in LD transplant rates for all age groups, including expansion of kidney paired donation, adoption of laparoscopic donor nephrectomy and use of incompatible LD...
  87. doi The impact of pancreas transplantation on kidney allograft survival
    S Browne
    Division of Nephrology, University of British Columbia, Vancouver, Canada
    Am J Transplant 11:1951-8. 2011
    ..Despite an increased risk of death early after pancreas transplantation, PAK recipients had a decreased long-term risk of kidney allograft failure compared to diabetic kidney ..
  88. doi High levels of donor CCL2/MCP-1 predict graft-related complications and poor graft survival after kidney-pancreas transplantation
    A C Ogliari
    Lab of Experimental Surgery, San Raffaele Scientific Institute, Milan, Italy
    Am J Transplant 8:1303-11. 2008
    ..Using simultaneous kidney-pancreas transplantation (SPK) as a model, we showed that brain death significantly increases circulating CCL2 levels in humans...
  89. doi Minimization protocols in pancreas transplantation
    Diego Cantarovich
    Institut de Transplantation et de Recherche en Transplantation, Nantes University Hospital, France
    Transpl Int 22:61-8. 2009
    ..e. antibody-mediated process). Long-term results of pancreas transplantation are now achieving comparable survival rates similar to the transplant of traditional organs such as ..
  90. doi Outcome of pancreas transplantation in recipients older than 50 years: a single-centre experience
    Elijah Ablorsu
    The Renal and Pancreas Transplant Unit, Manchester Royal Infirmary, Manchester, United Kingdom
    Transplantation 86:1511-4. 2008
    b>Pancreas transplantation (PT) remains the only treatment that can restore insulin independence among insulin-dependent diabetics...
  91. doi Magnetic resonance imaging in pancreas transplantation
    Rana Fattahi
    Department of Radiology, Saint Louis University, St Louis, MO, USA
    Top Magn Reson Imaging 20:49-55. 2009
    Magnetic resonance imaging (MRI) plays an important role in the evaluation of pancreas transplantation. Standard MRI, magnetic resonance angiography, and MR cholangiopancreatography can demonstrate the changes of the anatomy after ..
  92. doi Pancreas transplantation prevents morphologic and ultrastructural changes in pulmonary parenchyma of alloxan-induced diabetic rats
    C T Spadella
    Department of Surgery and Orthopedics, Botucatu School of Medicine, Sao Paulo State University, Botucatu, São, Paulo, Brazil
    Transplant Proc 42:2092-6. 2010
    The aim of this study was to evaluate whether pancreas transplantation (PT) is a suitable method for controlling histopathologic changes in lungs of alloxan-induced diabetic rats.
  93. doi Long-term results of pancreas transplantation in patients older than 50 years
    Peter Schenker
    Department of Surgery, Knappschafts Hospital, Ruhr University Bochum, Bochum, Germany
    Transpl Int 24:136-42. 2011
    ..The aim of our retrospective study was to evaluate pancreas transplantation (PT) outcomes in patients ≥ 50 years, as limited data exist in these patients...
  94. doi Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: a systematic review
    J Speight
    AHP Research, Brunel Science Park, Kingston Lane, Uxbridge, UK
    Diabet Med 27:812-22. 2010
    ..PROs in IT have not previously been compared directly with the closest alternate treatment option, pancreas transplant alone (PTA) or pancreas after kidney (PAK)...
  95. ncbi Reassessing the impact of cytomegalovirus infection in kidney and kidney-pancreas transplantation
    Bryan N Becker
    Division of Nephrology, Department of Medicine, School of Pharmacy, University of Wisconsin, Madison, Madison, WI, USA
    Am J Kidney Dis 39:1088-95. 2002
    ..This finding may require reassessment of prophylaxis strategies and the development of alternative or novel anti-CMV regimens...
  96. pmc Endothelin(A) receptor blockade reduces ischemia/reperfusion injury in pig pancreas transplantation
    Helmut Witzigmann
    Department of Abdominal, Transplantation and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Ann Surg 238:264-74. 2003
    The effect of prophylactic administration of a selective endothelin(A) receptor antagonist (ET(A)-RA) on ischemia/reperfusion injury in an experimental model of graft pancreatitis after pancreas transplantation was evaluated.
  97. ncbi Initial experience using histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation
    Santosh Potdar
    Division of Transplantation Surgery, University of Pittsburgh and the Thomas E Starzl Transplantation Institute, Pittsburgh, PA 15213 3236, USA
    Clin Transplant 18:661-5. 2004
    The colloid-based University of Wisconsin (UW) preservation solution has been used extensively in clinical pancreas transplantation. Experimental studies support the use of the crystalloid-based histidine-tryptophan-ketoglutarate (HTK) ..
  98. pmc Embryonic pig liver, pancreas, and lung as a source for transplantation: optimal organogenesis without teratoma depends on distinct time windows
    Smadar Eventov-Friedman
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 102:2928-33. 2005
    ....
  99. ncbi Developments in clinical islet, liver thoracic, kidney and pancreas transplantation in the last 5 years
    S Feng
    Department of Surgery, Division of Transplantation, University of California, San Francisco, USA
    Am J Transplant 6:1759-67. 2006
    ....
  100. ncbi Reduced immunogenicity of first-trimester human fetal pancreas
    Kerstin Brands
    Diabetes Transplant Unit, The Prince of Wales Hospital and The University of New South Wales, Sydney, New South Wales 2031, Australia
    Diabetes 57:627-34. 2008
    ..Tissue obtained from earlier stages might prove to be immune privileged, as has been shown for other tissues...
  101. doi Epidemiology of cytomegalovirus infection after pancreas transplantation
    Ajay K Parsaik
    Division of Endocrinology, Diabetes, Nutrition, and Metabolism, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Transplantation 92:1044-50. 2011
    ..has not been comprehensively studied after all three types of pancreas transplant (PT) including simultaneous pancreas-kidney transplantation (SPK), pancreas transplantation alone (PTA), and pancreas after kidney transplantation (PAK).

Research Grants59

  1. TRIAL OF ANTI-TNF ALPHA IN ISLET TRANSPLANTATION
    Andrew Shapiro; Fiscal Year: 2002
    ..transplantation will represent a major advance to the field, placing the procedure on a par with whole-pancreas transplantation in regards to donor utilization, but without the associated risk of major morbidity...
  2. Corneal Confocal Microscopy: a non-invasive surrogate for diabetic neuropathy
    RAYAZ AHMED MALIK; Fiscal Year: 2012
    ..gold standard for assessing small fiber damage), and is able to demonstrate early nerve repair after pancreas transplantation. We now propose to establish CCM as a valid surrogate for human DPN through a set of coordinated studies...
  3. David H Sachs; Fiscal Year: 2016
    ..the mixed chimerism approach and define the parameters that will allow rapid translation of these clinically relevant observations to treatment of diabeti patients who are candidates for kidney/pancreas transplantation.
  4. New Solutions to Improve Islet Recovery after Machine Preservation of Pancreas
    Michael Taylor; Fiscal Year: 2009
    ..This research is focused on the development of new technologies (a perfusion machine and protective solutions) for improving the quality of pancreas preservation to yield larger numbers of high functioning islet cells. ..
  5. Ashok K Saluja; Fiscal Year: 2014
    ..Recently, the advent of endocrine pancreas transplantation programs has made healthy human exocrine pancreatic tissue from donor organs available for in vitro ..
  6. PETER CAWOOD BUTLER; Fiscal Year: 2016
    ..Both diseases can be cured by replacement of pancreatic beta cells by pancreas transplantation but this requires life long immunosuppression and there are far fewer organ donors than people with ..
  7. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    ..Finally, a separate group of streptozotocin-treated diabetic rodents will undergo heterotopic pancreas transplantation to determine how well pancreas transplantation compares with conventional insulin treatment in preventing ..
  8. Strategy to Cure Type 1 Diabetes
    Zhiguang Guo; Fiscal Year: 2003
    ..investigator of this proposal, has successfully performed the largest number of living related segmental pancreas transplantation and islet autotransplantation worldwide...
  9. Genetic Markers of Acute Pancreas Allograft Rejection
    Ann Cashion; Fiscal Year: 2002
    ..diagnosis, a similar technique to evaluate early markers of acute rejection is uniquely important in pancreas transplantation. We hypothesize that by measuring expression levels of 3 genes, perform, granzyme B, and Fas ligand, ..
  10. STUDIES OF PANCREAS TRANSPLANTATION IN DIABETES
    MARSHALL ORLOFF; Fiscal Year: 1980
    ..Work in our laboratory has produced a consistently successful technique of heterotopic pancreas transplantation, both with and without the duodenum, in rats...
  11. ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRD
    David Sachs; Fiscal Year: 2006
    Pancreatic islet transplantation is less efficient than whole organ pancreas transplantation in reversing the hyperglycemia of diabetes...
  12. ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRD
    David Sachs; Fiscal Year: 2003
    Pancreatic islet transplantation is less efficient than whole organ pancreas transplantation in reversing the hyperglycemia of diabetes...
  13. GLUCOSE HOMEOSTASIS AND THE SURGICALLY ALTERED PANCREAS
    JOHN HANKS; Fiscal Year: 1990
    ..disease processes (reduced beta cell mass - diabetes) as well as applicability of surgery in treatment (pancreas transplantation)...
  14. EFFECT OF PANCREAS TRANSPLANTS ON PATHOLOGY OF DIABETES
    MARSHALL ORLOFF; Fiscal Year: 1991
    ..There is justifiable interest, therefore, in pancreas transplantation (PT) and other forms of endocrine pancreas replacement therapy (ERPT) that might provide precise ..
  15. STRATEGIES FOR TREATMENT AND PREVENTION OF DIABETES
    Ali Naji; Fiscal Year: 2004
    ..of islet beta cell destruction and recurrence of autoimmune diabetes in the setting of islet or pancreas transplantation. The central theme of the present program project is the continuation of studies focused on the ..
  16. EX VIVO IMMUNOALTERATION OF PANCREAS ORGAN TRANSPLANTS
    JAMES THISTLETHWAITE; Fiscal Year: 1992
    ..toxic monoclonal antibodies will be investigated by applying the techniques developed with rat pancreas transplantation to other rat organ transplants (heart and kidney) as well as solid organ transplants (kidney) in the ..
  17. System to analyze factors affecting human islet yield
    Robert McCarthy; Fiscal Year: 2006
    ..rate, as measured by insulin independence > 1 year post transplant, is comparable to whole organ pancreas transplantation. The major barrier for routine clinical adoption of the Protocol is the poor recovery of islets from ..
  18. A Novel Hepatokine
    JAMES LARRICK; Fiscal Year: 2003
    ..purified HK-1 protects mice from acute CCI4-induced liver cell injury and augments the success of fetal pancreas transplantation. In phase I we will express the cDNA for HK-1 and purify sufficient quantities of protein for biological ..
  19. Recurrence of T1D in Pancreas Transplantation
    George Burke; Fiscal Year: 2009
    ..We have assembled a team of investigators with experience in pancreas transplantation (Burke, Miami) and the immunology of T1D (Pugliese, Miami;Nepom, Seattle) to study the key immunological ..
  20. E M Transdifferentiation in Proximal Tubule Cells
    Bryan Becker; Fiscal Year: 2004
    ..abstract_text> ..
  21. Angiotensin II Receptor Blockade and Chronic Rejection
    Bryan Becker; Fiscal Year: 2003
    ....
  22. Clinical Translational Research in Transplant Nephrology
    Bryan Becker; Fiscal Year: 2006
    ..It will also work to meet the NIH's goal of increasing the number of physician-scientists conducting high-quality patient-oriented research. ..
  23. Vascular risk after kidney transplantation
    Jennifer L Larsen; Fiscal Year: 2010
    ..The study will also provide preliminary evidence for the efficacy of Vitamin D and omega 3 fatty acid supplementation in modifying traditional and nontraditional CVD risk factors as well as CVD progression after KTX. ..
  24. Glucose Regulation of Pancreatic Islet Gene Experession
    RODERICK PAUL ROBERTSON; Fiscal Year: 2010
    ..We will study whether increasing antioxidant protection protects these cells and prevents deterioration of glucose control in diabetes. ..
  25. Bioluminescent Imaging of Pancreatic Islet Transplants
    Dixon Kaufman; Fiscal Year: 2005
    ..abstract_text> ..
  26. Mitochondrial and Oxidative Stress in Type 1 Diabetes
    S Mauer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  27. Pancreas Transporter Development and Validation
    Michael Taylor; Fiscal Year: 2006
    ..This research program is supported by collaboration with three major clinical centers interested in validation of this perfusion technology for their future use. [unreadable] [unreadable]..
  28. Renin Angiotensin System Blockage-DN (RASS)
    S Mauer; Fiscal Year: 2007
    ..Ancillary studies will evaluate the effects of treatment group on the development and progression of diabetic retinopathy and will develop predictors of study participants' compliance. ..
  29. Using Team Simulation to Improve Error Disclosure to Patients and Safety Culture
    Thomas Gallagher; Fiscal Year: 2007
    ..Improving team communication and disclosure following harmful errors can enhance transparency and safety culture, increase patient satisfaction, and ultimately promote patient safety. [unreadable] [unreadable] [unreadable] [unreadable]..
  30. GLUCAGON BIOSYNTHESIS AND METABOLISM
    JOEL HABENER; Fiscal Year: 2008
    ....
  31. SEPARATION OF GVH AND GVL IN MOUSE MODELS
    Megan Sykes; Fiscal Year: 2008
    ..abstract_text> ..
  32. ISLET OF LANGERHANS GRAFT MONITORING BY MAGNETIC RESONANCE IMAGING
    Thierry Berney; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. The Coronary Screening for Kidney Transplantation (COST) Study
    Bertram Kasiske; Fiscal Year: 2008
    ..The money spent on these procedures might be better directed to health care measures of proven efficacy. [unreadable] [unreadable] [unreadable]..
  34. Multi-Parametric Characterization of Human Islets: Predictor of Islet Quality, Po
    Luis Fernandez; Fiscal Year: 2008
    ..abstract_text> ..
  35. GLYCOPROTEIN HORMONE BIOSYNTHESIS AND ACTION
    JOEL HABENER; Fiscal Year: 2002
    ..These studies have potential relevance to understanding the molecular mechanisms controlling spermatogenesis and fertility. ..
  36. Immune Response to Polyomavirus Infection
    Parmjeet S Randhawa; Fiscal Year: 2010
    ..This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy. ..
  37. ORTHOTOPIC LIVER TRANSPLANTATION
    Thomas Starzl; Fiscal Year: 2001
    ..Moreover, the investigators will attempt to develop novel techniques to modify the number and character of the donor cells that ultimately reside in the recipient and promote tolerance to the allograft. ..
  38. CHIMERIC KIDNEY
    MARC HAMMERMAN; Fiscal Year: 2001
    ..Since transplanted metanephroi appear to be less immunogenic than adult kidneys, our studies will provide insight into the feasibility of a novel means of renal transplantation that could be applied to humans. ..
  39. VLA4 IN CTL MEDIATED ISLET ALLOGRAFT REJECTION
    Mark Stegall; Fiscal Year: 2001
    ..The approach may lead to novel forms of immune suppression that may benefit not only islet transplantation, but also other types of organ allografts. ..
  40. COMPATIBILITY OF SWINE STEM CELLS AND HUMAN STROMA
    Megan Sykes; Fiscal Year: 2002
    ....
  41. TRANSCRIPTION FACTORS AND THE ENDOCRINE PANCREAS
    JOEL HABENER; Fiscal Year: 2003
    ....
  42. T AND B CELL TOLERANCE IN HUMAN MIXED CHIMERAS
    Megan Sykes; Fiscal Year: 2003
    ....
  43. CHIMERIC KIDNEY
    MARC HAMMERMAN; Fiscal Year: 2003
    ..Our studies will provide insight into the physiology and feasibility of a novel means of renal transplantation that could be applied to humans. ..
  44. T and B Cell Tolerance via Marrow Transplantation
    Megan Sykes; Fiscal Year: 2003
    ....
  45. XENOGENEIC STEM CELL AND THYMIC REPLACEMENT IN AIDS
    Megan Sykes; Fiscal Year: 2004
    ..These Projects constitute a highly integrated pre-clinical and clinical program aimed at thymic xenotransplantation as an approach to achieving immune reconstitution in the treatment of HIV-infected people. ..
  46. MOLECULAR ICE CONTROL FOR ENGINEERED TISSUES
    Michael Taylor; Fiscal Year: 2003
    ..The potential markets are enormous. Cryopreservation methods, which result in retained viability and function, will be licensed to the tissue engineering industry. ..
  47. ICOS-B7h in Islet Transplant Rejection and Autoimmunity
    Andrew Shapiro; Fiscal Year: 2004
    ....
  48. PRESERVATION OF LIVER SLICES BY VITRIFICATION
    Michael Taylor; Fiscal Year: 2005
    ..The molecular ice control formulations which provide the highest tissue viability and least interstitial ice formation will be tested in larger animal and human PCLS tissues in a sub-sequent Phase II SBIR proposal. ..
  49. Renal & Cellular Studies in Type 1 Diabetic Patients
    S Mauer; Fiscal Year: 2007
    ..These studies will provide markers and predictors of DN risk, determine if these are genetically regulated or dependent on prior exposure to D, and identify DN pathogenetic pathways. ..
  50. Gene Polymorphisms and Kidney Transplant Outcome
    William Oetting; Fiscal Year: 2005
    ..abstract_text> ..
  51. Live Unrelated Kidney Donor & Sibling Follow-up Study
    Bertram Kasiske; Fiscal Year: 2005
    ..Altogether, this study will provide useful information that will improve the informed consent for living kidney donors and enhance our knowledge of the role of the kidney, if any, in CVD. ..
  52. Proteomics in Type 1 Diabetes and its Complications
    S Mauer; Fiscal Year: 2005
    ..These studies could provide surrogate markers of DN and TIDM risk and provide insights into the pathogenesis of TIDM and its renal complications. ..
  53. Donation After Cardiac Death for Isolated Pancreatic Is*
    Luis Fernandez; Fiscal Year: 2006
    ..In addition, the development of rapid, accurate, and predictive tests of islet viability and function post isolation will contribute to significant improvements in post transplant success. ..
  54. PANCREATIC ISLET-DERIVED STEM CELLS
    JOEL HABENER; Fiscal Year: 2002
    ..As proposed in this application, transplantation of NIPs directly into the pancreata of STZ-induced and NOD diabetic mice will differentiate NIPs into Beta-cells and permanently cure the diabetes. ..
  55. Manipulation of intracellular pH for treatment of NIDDM
    Subhadra Gunawardana; Fiscal Year: 2006
    ....
  56. NOTCH2 AND B LYMPHOCYTE DEVELOPMENT
    Christian Kuhr; Fiscal Year: 2003
    ..Knowledge gained from these studies will provide insights into the control of normal lymphocyte maturation that may be of clinical import in understanding cellular aspects of solid organ graft rejection. ..