inbred akr mice

Summary

Top Publications

  1. ncbi Characterization of peripheral circadian clocks in adipose tissues
    Sanjin Zvonic
    Stem Cell Laboratory, Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Diabetes 55:962-70. 2006
  2. ncbi Senescence-accelerated mouse (SAM): a novel murine model of senescence
    T Takeda
    Department of Senescence Biology, Kyoto University, Japan
    Exp Gerontol 32:105-9. 1997
  3. ncbi Absence of CC chemokine ligand 2 results in an altered Th1/Th2 cytokine balance and failure to expel Trichuris muris infection
    Matthew L deSchoolmeester
    Department of Immunology, Microbiology, and Development, University of Manchester School of Biological Sciences, Manchester, United Kingdom
    J Immunol 170:4693-700. 2003
  4. pmc Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
    Alexander M Owyang
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 203:843-9. 2006
  5. pmc RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
    David Artis
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:13596-600. 2004
  6. pmc B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris
    N M Blackwell
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Infect Immun 69:3860-8. 2001
  7. ncbi Blockade of PSGL-1 attenuates CD14+ monocytic cell recruitment in intestinal mucosa and ameliorates ileitis in SAMP1/Yit mice
    Takuya Inoue
    National Defense Medical College, 2 3 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Leukoc Biol 77:287-95. 2005
  8. ncbi Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma
    C L Karp
    Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MA, USA
    Nat Immunol 1:221-6. 2000
  9. pmc Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
    M M Kosiewicz
    Departments of Medicine and Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Clin Invest 107:695-702. 2001
  10. pmc Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
    Timothy S Olson
    Department of Molecular Physiology and Cardiovascular Research Center, University of Virginia Health Science Center, Charlottesville 22908, USA
    J Clin Invest 114:389-98. 2004

Research Grants

Detail Information

Publications235 found, 100 shown here

  1. ncbi Characterization of peripheral circadian clocks in adipose tissues
    Sanjin Zvonic
    Stem Cell Laboratory, Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Diabetes 55:962-70. 2006
    ....
  2. ncbi Senescence-accelerated mouse (SAM): a novel murine model of senescence
    T Takeda
    Department of Senescence Biology, Kyoto University, Japan
    Exp Gerontol 32:105-9. 1997
    ..The genetic background and significance of SAM development are discussed...
  3. ncbi Absence of CC chemokine ligand 2 results in an altered Th1/Th2 cytokine balance and failure to expel Trichuris muris infection
    Matthew L deSchoolmeester
    Department of Immunology, Microbiology, and Development, University of Manchester School of Biological Sciences, Manchester, United Kingdom
    J Immunol 170:4693-700. 2003
    ..Elevated levels of IL-12 are produced by polarizing APCs, and the composition of the APC environment itself is perturbed, with reduced numbers of macrophages...
  4. pmc Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
    Alexander M Owyang
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 203:843-9. 2006
    ..Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract...
  5. pmc RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
    David Artis
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:13596-600. 2004
    ..Together, these results suggest that intestinal goblet cell-derived RELMbeta may be a novel Th2 cytokine-induced immune-effector molecule in resistance to GI nematode infection...
  6. pmc B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris
    N M Blackwell
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Infect Immun 69:3860-8. 2001
    ..Our results as a whole describe the first detailed report of a critical role for B cells in resistance to an intestinal nematode...
  7. ncbi Blockade of PSGL-1 attenuates CD14+ monocytic cell recruitment in intestinal mucosa and ameliorates ileitis in SAMP1/Yit mice
    Takuya Inoue
    National Defense Medical College, 2 3 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Leukoc Biol 77:287-95. 2005
    ....
  8. ncbi Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma
    C L Karp
    Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MA, USA
    Nat Immunol 1:221-6. 2000
    ..The role of complement in modulating susceptibility to asthma highlights the importance of immunoregulatory events at the interface of innate and adaptive immunity in disease pathogenesis...
  9. pmc Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
    M M Kosiewicz
    Departments of Medicine and Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Clin Invest 107:695-702. 2001
    ..To our knowledge, these data provide the first direct evidence that Th1-producing T cells mediate intestinal inflammation in a spontaneous animal model of human Crohn's disease...
  10. pmc Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
    Timothy S Olson
    Department of Molecular Physiology and Cardiovascular Research Center, University of Virginia Health Science Center, Charlottesville 22908, USA
    J Clin Invest 114:389-98. 2004
    ..SAMP1/YitFc B cells prevent alpha(E)beta(7)(+)CD4(+) T cells from suppressing effector T cell proliferation. We conclude that SAMP1/YitFc MLN B cells contribute to the development of SAMP1/YitFc ileitis...
  11. ncbi L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 174:2343-52. 2005
    ..Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine...
  12. pmc Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite
    R Datta
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Infect Immun 73:4025-33. 2005
    ....
  13. ncbi The characterization of intraepithelial lymphocytes, lamina propria leukocytes, and isolated lymphoid follicles in the large intestine of mice infected with the intestinal nematode parasite Trichuris muris
    Matthew C Little
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 175:6713-22. 2005
    ..Furthermore, we demonstrate the organogenesis of these structures in response to T. muris infection...
  14. ncbi Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc
    Kosuke Kozaiwa
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Gastroenterology 125:477-90. 2003
    ..We performed a genetic analysis of a (B6 x SAMP1/Fc)F(2) cross to localize the genes regulating intestinal inflammation in this model...
  15. pmc The development of a highly informative mouse Simple Sequence Length Polymorphism (SSLP) marker set and construction of a mouse family tree using parsimony analysis
    Philip D Witmer
    Center for Inherited Disease Research CIDR, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Genome Res 13:485-91. 2003
    ..With this large data set, we sought to reconstruct a phylogenetic history of the laboratory mouse using Wagner parsimony analysis. Our results are largely congruent with the known history of inbred mouse strains...
  16. ncbi The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics
    Sonya G Wilson
    Department of Psychology and Program in Neuroscience, University of Illinois at Urbana Champaign, Champaign, Illinois, USA
    J Pharmacol Exp Ther 304:547-59. 2003
    ..However, the genes in question may affect antinociception indirectly, via a primary action on baseline nociceptive sensitivity...
  17. ncbi Interaction of the nicotinic cholinergic system with ethanol withdrawal
    Christopher M Butt
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    J Pharmacol Exp Ther 308:591-9. 2004
    ..These results suggest that the nicotinic cholinergic system and the A/T polymorphism modulate ethanol withdrawal...
  18. ncbi Genetic determinants of sensitivity to pentobarbital in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, VA Medical Center, Oregon Health and Science University, Portland, OR 97201, USA
    Psychopharmacology (Berl) 161:408-16. 2002
    ..We postulated that genetic determinants of different responses to pentobarbital (PB) in mice would differ from response to response...
  19. pmc Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice
    P E Thomas
    Genetics 74:655-9. 1973
    ..Genetic analyses and strain surveys indicate that the In and Ahh loci are identical, or very closely linked...
  20. ncbi In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice
    Jonathan D Smith
    Rockefeller University, New York, NY, USA
    Arterioscler Thromb Vasc Biol 23:117-22. 2003
    ....
  21. ncbi Antibody to soluble 1,3/1,6-beta-D-glucan, SCG in sera of naive DBA/2 mice
    Toshie Harada
    Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    Biol Pharm Bull 26:1225-8. 2003
    ..These results suggested that DBA/1 and DBA/2 strains carry specific and unique immunological characteristics to branched 1,3-/1,6-beta-glucan...
  22. ncbi Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci
    J R Robinson
    J Biol Chem 249:5851-9. 1974
  23. ncbi Structural polymorphism of murine complement factor H controlled by a locus located between the Hc and the beta 2M locus on the second chromosome of the mouse
    S Natsuume-Sakai
    J Immunol 134:2600-6. 1985
    ..This was shown by phenotyping the Hc locus and H locus with backcross progenies between A/J (one of strain with H.1) and MoA (one of strain with H.2). The recombination frequency between these two loci was 0.17 +/- 0.046...
  24. ncbi T cell receptor-gamma allele-specific selection of V gamma 1/V delta 4 cells in the intestinal epithelium
    Kalliopi Grigoriadou
    Unité du Développement des Lymphocytes, Center National de la Recherche Scientifique, Unite de Recherche Associee, Institut Pasteur, Paris, France
    J Immunol 169:3736-43. 2002
    ....
  25. ncbi In vivo priming of mouse CTL precursors directed to product of a newly defined minor H-42 locus is under a novel control of class II MHC gene
    H Ishikawa
    J Immunol 135:3681-5. 1985
    ....
  26. ncbi Application of inter-simple sequence repeat PCR to mouse models: assessment of genetic alterations in carcinogenesis
    Fernando Benavides
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Genes Chromosomes Cancer 35:299-310. 2002
    ..These PCR-based fingerprints provide a novel approach to assessing the number and onset of mutational events in mouse tumors and will help to understand better the mechanisms of carcinogenesis in mouse models...
  27. ncbi Mechanisms of enhanced macrophage-mediated prostaglandin E2 production and its suppressive role in Th1 activation in Th2-dominant BALB/c mice
    Etsushi Kuroda
    Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    J Immunol 170:757-64. 2003
    ....
  28. ncbi A new lymphocyte cell surface antigen, Ly-22.2, controlled by a locus on chromosome 4 and a second unlinked locus
    D Meruelo
    J Immunol 130:946-50. 1983
    ..Strain distribution studies show Ly-22.2 is present in all strains examined except B10-derived congenic strains. It is of interest that C57BL/6 and C57BL/10 mice differ in the expression of this antigen...
  29. ncbi Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG)
    P Gros
    J Immunol 131:1966-72. 1983
    ....
  30. ncbi Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, 10314, USA
    Neuroscience 115:463-9. 2002
    ..The data also demonstrate that the differential genetic liability to morphine physical dependence begins with, and is predicted by, the first morphine exposure...
  31. ncbi The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles
    P Gosselin
    Institut Armand Frappier, Universite du Quebec, Laval, Canada
    Int Immunol 9:533-40. 1997
    ..Together with our and others previous observations, these results identify the NK2.1/Ly-49C antigen as a receptor for MHC class I molecules whose expression is regulated by host MHC genes...
  32. pmc Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes
    T Schulte
    Institute of Clinical Microbiology and Immunology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    J Exp Med 186:1419-29. 1997
    ..These findings suggest that the altered ligand binding behavior of the newly described IL-4R allotype may influence the IL-4 responsiveness, thus contributing to the diverse phenotypes of inbred mouse strains in IL-4-dependent diseases...
  33. pmc The mouse intracisternal A particle-promoted placental gene retrotransposition is mouse-strain-specific
    A Chang-Yeh
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218
    Proc Natl Acad Sci U S A 90:292-6. 1993
    ..The symbol Ipp is being used for this gene in all major mouse data bases and in the comparative section of the human genome data base...
  34. ncbi Studies on natural killer (NK) cells. I. NK cell specific antibodies in CE anti-CBA serum
    R C Burton
    J Immunol 126:1985-9. 1981
    ..2, and the corresponding antibodies as anti-NK-1.2. However, the possibility that CE anti-CBA serum detects a new system of NK-specific antigen has not been excluded...
  35. ncbi Polygenic control of the immune response to F antigen
    D M Silver
    Immunogenetics 12:237-51. 1981
    ..Such complex genetic control suggests regulation by a number of independently segregating loci whose function it is to limit the autoimmune response to F antigen...
  36. ncbi Ly 9, an alloantigenic marker of lymphocyte differentiation
    B J Mathieson
    J Immunol 125:2127-36. 1980
    ..Cytotoxic elimination experiments confirm that Ly 9 is expressed on at least 2 different T cell functional subsets and B cells...
  37. ncbi Definition of a new T lymphocyte cell surface antigen, Ly 11.2
    D Meruelo
    J Immunol 125:2713-8. 1980
    ..Although the locus coding for this antigen appears to be closely linked to the minor histocompatibility locus H-30 and to the locus coding for Ly 6.2, a chromosome assignment has not yet been made for my of these loci...
  38. ncbi Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice
    P Gros
    J Immunol 127:2417-21. 1981
    ..The product of the Bcg gene was found to influence the early phase of host response resulting in the genetic advantage of the resistant host being demonstrable as early as 24 hr after infection...
  39. ncbi Mouse strain variation in maximal electroshock seizure threshold
    Thomas N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    Brain Res 936:82-6. 2002
    ..We conclude that MEST represents a useful tool for dissecting the multifactorial nature of seizure sensitivity in mice...
  40. ncbi Evidence for a new lymphocyte-stimulating determinant (Lsd) detected by alloreactive T cell lines
    B Opalka
    Eur J Immunol 13:24-30. 1983
    ..BR anti-C57BL/10). The third clone (BD7, C57BL/6 anti-CBA/J) was probably originally directed against Lsd. So far, Lsd is only characterized by stimulation of T cell proliferation, and its physiological function is not yet known...
  41. ncbi H-41, a new minor histocompatibility locus. I. Histogenetic analysis
    A Juretic
    J Immunol 133:2950-4. 1984
    ..The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain...
  42. ncbi Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity
    William R Lariviere
    Department of Psychology and Neuroscience Program, University of Illinois at Urbana Champaign, IL 61820, USA
    Pain 97:75-86. 2002
    ....
  43. ncbi Control of mouse hepatitis virus replication in macrophages by a recessive gene on chromosome 7
    M S Smith
    J Immunol 133:428-32. 1984
    ..We have identified and mapped a new locus that imparts resistance to productive infection of mouse hepatitis virus MHV(A59) in cultured macrophages. This locus maps 41.5 centimorgans from the albino locus on chromosome 7...
  44. ncbi Cell-mediated cytotoxicity to non-MHC alloantigens on mouse epidermal cells. I. H-2 restricted reactions among strains sharing the H-2k haplotype
    D Steinmuller
    J Immunol 126:1747-53. 1981
  45. ncbi Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate concentration (Gtpc) to mouse chromosome 9
    J P Jenuth
    Department of Paediatrics, Faculty of Medicine, University of Calgary, Canada
    Genome 37:399-404. 1994
    ..A test for linkage of Gtpc to transferrin (Trf) on chromosome 9 gave evidence of linkage with an observed recombination frequency of 14.6 +/- 5.5 and a 99% confidence interval of 3.9-33.9 cM...
  46. ncbi Linkage of a 7S RNA sequence and kappa light chain genes in the mouse
    B A Taylor
    Immunogenetics 22:471-81. 1985
    ..The Rn7s-6 variant is a plus/minus variant; no sequence allelic to Rn7s-6 is found in inbred strains that share the Ly-3a-Igk-Ef1a haplotype...
  47. ncbi Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus
    D M Gibson
    J Immunol 121:1585-90. 1978
    ..6 map units) to the Ly-2,3 locus on mouse Chromosome 6. The locus controlling normal light chain IF-patterns has been designated Ef1...
  48. ncbi In vivo hydrodynamic delivery of cDNA encoding IL-2: rapid, sustained redistribution, activation of mouse NK cells, and therapeutic potential in the absence of NKT cells
    John R Ortaldo
    Laboratory of Experimental Immunology, National Cancer Institute Center for Cancer Research, Frederick, MD 21702, USA
    J Immunol 175:693-9. 2005
    ....
  49. ncbi Chronic pain and genetic background interact and influence opioid analgesia, tolerance, and physical dependence
    De Yong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Pain 121:232-40. 2006
    ..We conclude that chronic inflammatory pain and genetics interact to modulate the analgesic potency of morphine, tolerance, and physical dependence...
  50. ncbi Inherited immunoglobulin idiotypes of the mouse
    O Makela
    Immunol Rev 34:119-38. 1977
  51. ncbi Mice with blunted hypoxic ventilatory response are susceptible to respiratory disturbance during hypoxia
    Tetsuya Adachi
    Department of Cardiovascular and Respiratory Medicine, Tohoku University School of Medicine, Kawauchi 41, Sendai 980 8576, Japan
    Tohoku J Exp Med 209:125-34. 2006
    ..We suggest that a lower hypoxic ventilatory response may be a risk factor for apnea under hypoxia...
  52. ncbi Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification
    Zouhair Aherrahrou
    Medizinische Klinik II, University of Luebeck, Luebeck, Germany
    Physiol Genomics 28:203-12. 2007
    ..T153I changes might affect the biological function of EMP-3 gene product after injury. Using this combined approach, we ultrafine-mapped the Dyscalc1 locus to an 80-Kb region and identified EMP-3 as a new candidate gene for DCC...
  53. ncbi Sleep and temperature responses of inbred mice with Candida albicans-induced pyelonephritis
    Linda A Toth
    Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Comp Med 56:252-61. 2006
    ..C. albicans-infected mice may be a useful model for identifying the genes and mechanisms that link sleep, temperature, fatigue, and the immune response...
  54. pmc Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis
    K Higuchi
    Department of Senescence Biology, Kyoto University, Japan
    Biochem J 279:427-33. 1991
    ..The molecular type of apoA-II may be a factor involved in the development of senile amyloidosis in mice...
  55. pmc Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
    Jessica J Nadler
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599 7264, USA
    Genetics 174:1229-36. 2006
    ..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
  56. pmc The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study
    Wilhelm Bone
    Schering AG, Müllerstr 178, 13342 Berlin, Germany
    Reprod Biol Endocrinol 5:1. 2007
    ..To gain more insight into this species difference we have now evaluated the reproductive effects of miglustat in rabbits, in multiple mouse strains and in interstrain hybrid mice...
  57. ncbi Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis
    Stefan M Muehlbauer
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 6:758-66. 2007
    ..We propose that caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression reported in LT-treated BALB/c mice...
  58. ncbi The location of the C3 and GLO (glyoxalase 1) loci of the IXth linkage group in mice
    P Rubinstein
    J Immunol 122:2584-9. 1979
  59. ncbi Enhancer elements in the mouse CYP1A2 gene: a comparative sequencing among different inbred mouse strains
    Olga N Mikhailova
    Institute of Molecular Biology and Biophysics, Novosibirsk 630117, Russia
    Mutat Res 632:99-103. 2007
    ..The absence of mutation prescribing the phenotype in the CYP1A2 gene was found. The region studied seems to be a highly conserved in mice and not to be associated with interstrain differences in constitutive CYP1A2 enzyme activity...
  60. pmc Significant gene content variation characterizes the genomes of inbred mouse strains
    Gene Cutler
    Lead Discovery, Amgen, South San Francisco, California 94080, USA
    Genome Res 17:1743-54. 2007
    ..Using a whole-genome association analysis, we demonstrate that complex multigenic phenotypes, such as food intake, can be associated with specific copy number changes...
  61. ncbi Idiotypic analysis of the response of C57BL/6 mice to the (4-hydroxy-3-nitrophenyl)acetyl group
    R S Jack
    Eur J Immunol 7:559-65. 1977
    ..Breeding experiments demonstrated that the marker segregated with the heavy chain linkage group...
  62. pmc Plasminogen alleles influence susceptibility to invasive aspergillosis
    Aimee K Zaas
    Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 4:e1000101. 2008
    ..Furthermore, we demonstrated that plasminogen directly binds to Aspergillus fumigatus. We propose that genetic variation within the plasminogen pathway influences the pathogenesis of this invasive fungal infection...
  63. ncbi Genetic influence on daily wheel running activity level
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina Charlotte, Charlotte 28223, USA
    Physiol Genomics 19:270-6. 2004
    ..In conclusion, these data indicate that daily running wheel activity level in mice is significantly affected by genetic background and sex...
  64. ncbi Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450
    D W Nebert
    Mol Pharmacol 8:651-66. 1972
  65. pmc An Eco RI restriction length polymorphism at the murine L-myc locus
    R Dolcetti
    I Centro di Riferimento Oncologico, Aviano, Italy
    Nucleic Acids Res 16:11853. 1988
  66. ncbi Mapping blood pressure loci in (A/J x B6)F2 mice
    David D L Woo
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Physiol Genomics 15:236-42. 2003
    ..Defining the molecular differences between the A/J and the B6 alleles at these novel loci with major influences on the BP phenotype will contribute to our understanding of the complex genetics of BP control...
  67. ncbi Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
    M L Mucenski
    NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
    Oncogene Res 2:219-33. 1988
    ..These results suggest that Evi-1 represents a new locus involved in myeloid disease...
  68. ncbi Electroretinography as a screening method for mutations causing retinal dysfunction in mice
    Claudia Dalke
    GSF National Research Center for Environment and Health, Institutes of Developmental Genetics, Clinical Cooperation Group Ophthalmogenetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 45:601-9. 2004
    ..To detect mice with hereditary retinal impairment, a high-throughput electroretinography (ERG) screening system was established...
  69. ncbi Genotype-dependence of gabapentin and pregabalin sensitivity: the pharmacogenetic mediation of analgesia is specific to the type of pain being inhibited
    Elissa J Chesler
    Department of Psychology and Neuroscience Program, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Pain 106:325-35. 2003
    ..This has considerable implications for ongoing pharmacogenetic investigations and, more generally, for the choices of preclinical models of pain used in drug development...
  70. ncbi Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiation
    F Lynch
    Department of Experimental Pathology, John Curtin School of Medical Research, Canberra, Australia
    Eur J Immunol 19:223-9. 1989
    ..Expression of Ly-24 by thymocytes is discussed in the context of current models of intrathymic T cell differentiation...
  71. ncbi Strain distribution pattern of susceptibility to immune-mediated nephritis
    Chun Xie
    Simmons Arthritis Research Center, Division of Rheumatology, Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:5047-55. 2004
    ..Detailed studies to dissect out the immunological and genetic basis of renal disease in these three strains are clearly warranted...
  72. ncbi Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis
    Amol S Rangnekar
    Department of Medicine, Division of Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Liver Int 26:1000-5. 2006
    ....
  73. ncbi Restriction fragment analysis of V preB and lambda 5 within the genus Mus
    L A D'Hoostelaere
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 19:37-42. 1989
    ..These results suggest that V preB1, V preB2 and lambda 5 have been present for over 12 million years...
  74. pmc A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14
    J Shaughnessy
    Laboratory of Genetics, NCI, Bethesda, MD 20892
    Nucleic Acids Res 17:2881. 1989
  75. ncbi Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model-end of 1971
    H E Skipper
    Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, AL, USA
    Cancer Chemother Rep 56:273-87, 289-314. 1972
    ....
  76. pmc Infection of central nervous system cells by ecotropic murine leukemia virus in C58 and AKR mice and in in utero-infected CE/J mice predisposes mice to paralytic infection by lactate dehydrogenase-elevating virus
    G W Anderson
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455 0312
    J Virol 69:308-19. 1995
    ....
  77. ncbi Anticancer potential of Viva-Natural, a dietary seaweed extract, on Lewis lung carcinoma in comparison with chemical immunomodulators and on cyclosporine-accelerated AKR leukemia
    E Furusawa
    Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu
    Oncology 46:343-8. 1989
    ..Viva-Natural reversed the potentiation effect of ciclosporin on the development of leukemia in AKR mice at preleukemic stage...
  78. pmc Age-dependent poliomyelitis of mice: expression of endogenous retrovirus correlates with cytocidal replication of lactate dehydrogenase-elevating virus in motor neurons
    C H Contag
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455 0312
    J Virol 63:4362-9. 1989
    ..We discuss potential mechanisms for the novel dual-virus etiology of age-dependent poliomyelitis of mice...
  79. pmc Oncogenicity of AKR mink cell focus-inducing murine leukemia virus correlates with induction of chronic phosphatidylinositol signal transduction
    A M al Salameh
    Department of Microbiology, University of Texas Medical Branch, Galveston 77550
    J Virol 66:6125-32. 1992
    ..g., ras and fms). Its chronic induction by oncogenic MCF MuLV may thus initiate thymocyte transformation...
  80. pmc Loss of pathogenicity of spleen focus-forming virus after pseudotyping with Akv
    K S Jones
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    J Virol 62:511-8. 1988
    ..Thus, the helper virus used to rescue SFFV plays at least a quantitatively important role in the early stage of FV disease and a crucial role in the late stage of the disease in vivo...
  81. pmc A single point mutation in the envelope gene is responsible for replication and XC fusion deficiency of the endogenous ecotropic C3H/He murine leukemia virus and for its repair in culture
    G Sithanandam
    Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701
    J Virol 62:932-43. 1988
    ....
  82. ncbi Effect of pretazettine and viva-natural, a dietary seaweed extract, on spontaneous AKR leukemia in comparison with standard drugs
    E Furusawa
    Department of Pharmacology, John A Burns School of Medicine, University of Hawaii, Honolulu
    Oncology 45:180-6. 1988
    ..Also, PTZ has been found to reverse the leukemia-enhancing effect of ciclosporin in AKR mice at preleukemic stage...
  83. pmc Potential progenitor sequences of mink cell focus-forming (MCF) murine leukemia viruses: ecotropic, xenotropic, and MCF-related viral RNAs are detected concurrently in thymus tissues of AKR mice
    F Laigret
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 62:376-86. 1988
    ..We have also described the unique structure of the 6.0-kb MCF-related RNAs which were expressed specifically in liver and kidney tissues of AKR mice; these RNAs contained an upstream non-MuLV transcriptional regulatory element...
  84. ncbi Termination of the B cell lymphoma dormant state in thymectomized AKR mice
    N Haran Ghera
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 148:2947-52. 1992
    ..These results suggest that T cell subsets and/or their products are involved in the proliferation arrest of potential lymphoma cells present in thymectomized AKR mice...
  85. ncbi Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine: I. Activation of natural killer cells in mice
    B S Sharma
    Department of Immunology, ICN Pharmaceuticals, Costa Mesa, CA 92626
    Immunopharmacol Immunotoxicol 14:1-19. 1992
    ..Low concentrations of IL-2 (0.25-5 U/ml) that induce little or no NK cell activity, when used in combination with 7T8OG, elicited significant enhancement of NK cell cytotoxicity. In contrast, IFN and 7T8OG showed no such synergism...
  86. ncbi The occurrence of vacuolation, and periodic acid-Schiff (PAS)-positive granules and plaques in the brains of C57BL/6J, AKR, senescence-prone (SAMP8) and senescence-resistant (SAMR1) mice infected with various scrapie strains
    Xuemin Ye
    Department of Virology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res 995:158-66. 2004
    ..These findings suggest that PGS accumulation was more dependent on the genetic information of the mouse strain, whereas PP and vacuolation patterns depended on the scrapie strain-mouse strain combination...
  87. ncbi Allelic differences in TCR gamma-chains alter gamma delta T cell antigen reactivity
    H Kalataradi
    National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    J Immunol 153:1455-65. 1994
    ..We propose that amino acid differences among those encoded by the AKR V gamma 1-J gamma 4-C gamma 4 gene are responsible for the lack of response, and reduce the ability of the TCR-gamma delta to bind the relevant Ag...
  88. pmc A direct demonstration of recombination between an injected virus and endogenous viral sequences, resulting in the generation of mink cell focus-inducing viruses in AKR mice
    N L DiFronzo
    Center for Virology, Children s National Medical Center, Washington, DC 20010 2970
    J Virol 67:3763-70. 1993
    ..Furthermore, the progression to leukemia was accelerated in mice that develop tumors containing proviruses with an MCF virus env gene, emphasizing the importance of the role of the MCF virus env gene product in transformation...
  89. ncbi Replication of lactate dehydrogenase-elevating virus in cells infected with murine leukaemia viruses in vitro
    T Inada
    Central Virus Diagnostic Laboratory, National Institute of Health, Tokyo, Japan
    J Gen Virol 72:2437-44. 1991
    ..These results may be relevant to the mechanisms of paralytic disease caused by LDV infection in C58 mice...
  90. ncbi Amelioration of acute graft-versus-host disease and re-establishment of tolerance by short-term treatment with an anti-TCR antibody
    T Maeda
    Department of Immunology, Kyushu University, Fukuoka, Japan
    J Immunol 153:4311-20. 1994
    ..Collectively, these data indicate that a short-term treatment of mice having GVHD with an anti-TCR-alpha beta mAb, starting even after disease onset, can re-establish host-specific tolerance, at least to the host-histo-compatibility Ag...
  91. pmc Differential cell killing by lymphomagenic murine leukemia viruses occurs independently of p53 activation and mitochondrial damage
    Suparna Nanua
    Department of Immunology and Microbiology and the Karmanos Cancer Institute, Wayne State University, 540 E Canfield Avenue, Detroit, MI 48201, USA
    J Virol 78:5088-96. 2004
    ..These results demonstrate that MCF13 MLV induces apoptosis preferentially in cells in which superinfection occurs, and the mechanism involved is independent of p53 activation and mitochondrial damage...
  92. ncbi Importance of suppressor T cells in cyclophosphamide-induced tolerance to the non-H-2-encoded alloantigens. Is mixed chimerism really required in maintaining a skin allograft tolerance?
    Y Tomita
    Department of Immunology, Kyushu University Fukuoka, Japan
    J Immunol 144:463-73. 1990
    ..Moreover, the generation of the Ts cells does not necessarily require the establishment of a long term mixed chimeric state...
  93. pmc Coexistence in lactate dehydrogenase-elevating virus pools of variants that differ in neuropathogenicity and ability to establish a persistent infection
    Z Chen
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455, USA
    J Virol 71:2913-20. 1997
    ..30-amino-acid ectodomain of VP-3P, which seems to carry the neutralization epitope(s) and forms part of the virus receptor attachment site...
  94. ncbi Lactate dehydrogenase-elevating virus variants: cosegregation of neuropathogenicity and impaired capability for high viremic persistent infection
    Z Chen
    University of Minnesota, Department of Microbiology, Minneapolis 55455, USA
    J Neurovirol 4:560-8. 1998
    ..The only consistent and biologically relevant molecular difference we have observed between neuropathogenic and non-neuropathogenic LDVs is the number of polylactosaminoglycan chains associated with the ectodomain of VP-3P...
  95. ncbi Cycloheximide increases endogenous retroviral RNA levels in murine liver and lung
    G Manenti
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan. Italy
    Tumori 75:217-21. 1989
    ..The strains genetically resistant to lung carcinogenesis (C3Hf, C57BL/6J) showed higher lung basal levels and higher cycloheximide inducibility of mRNAs homologous to Mo-MuLV than the susceptible strains (A/J, BALB/c)...
  96. pmc Characterisation of the protective immune response following subcutaneous vaccination of susceptible mice against Trichuris muris
    Helen Dixon
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Int J Parasitol 40:683-93. 2010
    ..High levels of serum IgG1 and cell-bound IgG1 in the colon of mice protected by the ES/IFA vaccine suggest that antibody may be involved in vaccination-induced worm expulsion...
  97. ncbi Abnormalities in the cerebellum and brainstem in homozygous lurcher mice
    A Resibois
    Laboratoire d Histologie, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    Neuroscience 80:175-90. 1997
    ..Lastly, they confirm the absence of effect of the mutation on the neurons of the inferior olivary complex...
  98. ncbi Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile
    D Q Wang
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, and Harvard Digestive Diseases Center, Boston, MA 02115, USA
    J Lipid Res 38:1395-411. 1997
    ..iii) Mucin gel accumulation, crystallization, and stone formation are rare in AKR mice. This definition of the physical chemistry of lithogenesis should aid in further elucidation of the Lith genes and the proteins they encode...
  99. ncbi Selective antibody neutralization prevents neuropathogenic lactate dehydrogenase-elevating virus from causing paralytic disease in immunocompetent mice
    Z Chen
    University of Minnesota, Department of Microbiology, Minneapolis 55455, USA
    J Neurovirol 5:200-8. 1999
    ....
  100. pmc The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3
    Marc Andre Langlois
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom CB2 0QH
    J Virol 83:11550-9. 2009
    ....
  101. ncbi Genetic and immunological factors interact in a mouse model of CNS antiphospholipid syndrome
    Aviva Katzav
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Behav Brain Res 169:289-93. 2006
    ..Qualitative differences in behavioral patterns may be due to nervous system as well as immune genetic factors. The minimal effect of APS in C57BL/6 mice may provide a suitable background for the study of transgenes in these mice...

Research Grants60

  1. Regulation of Engraftment & Immunity by GD T Cells
    William Drobyski; Fiscal Year: 2005
    ....
  2. T CELL ADHESION MOLECULES IN MURINE LUPUS PNEUMONITIS
    Jeffrey Curtis; Fiscal Year: 2002
    ..Our long-term goal is to develop effective therapies to treat established SLE based on anti-adhesive strategies. ..
  3. LDV-INDUCED GENETICALLY RESTRICTED CNS DISEASE
    MARGO BRINTON; Fiscal Year: 1991
    ..The relative contribution of anti-E antibody or immune T cells to disease development will be investigated. Attempts will be made to infect cultured oligodendrocytes or astrocytes...
  4. NATURAL HOST CONTROL MECHANISMS IN LEUKEMIA
    Theodore Pincus; Fiscal Year: 1980
    ..We plan to learn whether immunological tolerance to virus antigens may influence leukemia development, and whether viral immunologic suppressor or enhancing activity may exist under certain conditions...
  5. VIRAL RECEPTORS & VACCINES IN LEUKEMIA
    SUSAN BURDETTE; Fiscal Year: 1990
    ..The last part of the study will be to immunize mice with anti-idiotypic antibody in order to generate an anti- retroviral response. Such immunizations will be used in protection experiments using several models of induced leukemia...
  6. LDH VIRUS: GROWTH IN MACROPHAGES & PERSISTENT INFECTION
    PETER PLAGEMANN; Fiscal Year: 1991
    ..We will also attempt to develop a cell culture line permissive for LDV replication for further biochemical studies of LDV replication and the in vitro titration of infectious LDV...
  7. LEUKEMIA IN AKR MOUSE: STUDIES ON RETROVIRAL RECEPTOR
    David Scadden; Fiscal Year: 1990
    ....
  8. METABOLIC EVENTS IN VIRUS-INDUCED LEUKEMOGENESIS
    ROBERT KEMP; Fiscal Year: 1980
    ..The study will hopefully provide a focal point for interfering with the chain of metabolic events that results in the virus-induced malignant evolution of lymphoid cells...
  9. MECHANISMS IN SUCCESSFUL THERAPY OF GVHD WITH MOAB
    ROBERT TRUITT; Fiscal Year: 2001
    ..Mechanistic insights gained from the studies, together with the biological principles identified, will facilitate the translational application of MoAb to clinical BMT. ..
  10. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2005
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  11. CD200 Expression on Apoptotic DCs and Immune Tolerance
    ROBERT TRUITT; Fiscal Year: 2005
    ..These studies will also provide new insight into a novel molecular pathway that is a target for enhancement of antitumor immunity and for prevention of graft rejection. ..
  12. Allospecific Immunoregulatory T Cells in BMT Recipients
    ROBERT TRUITT; Fiscal Year: 2003
    ....
  13. Facilitation/Barriers in Non-Myeloablative Transplants
    Thai Cao; Fiscal Year: 2006
    ..abstract_text> ..
  14. DNA FORMS OF MURINE LEUKEMIA VIRUSES
    FAYTH YOSHIMURA; Fiscal Year: 2007
    ..The results of these studies will enhance our understanding of the role of apoptosis in the development of neoplastic disease. ..
  15. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..
  16. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
  17. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  18. ABCA1, ApoAI, and Lipid Efflux
    Jonathan Smith; Fiscal Year: 2008
    ..In addition, this study will include the identification of the apoAl oxidative modification by the enzyme myeloperoxidase that diminishes its lipid acceptor activity. ..
  19. Control of Physical Activity by Genetic Factors
    J Lightfoot; Fiscal Year: 2003
    ..This will be the first project investigating the genetic basis of physical activity level to use these techniques that have already proven successful in other fields (e.g. cystic fibrosis). ..
  20. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  21. Developing New Skills for Mouse Neurogenetics Research
    WAYNE FRANKEL; Fiscal Year: 2004
    ..We request funds to support the travel and lodging of two Visiting Investigators and two Students at any given time, plus the supplies, animal care resources and faculty salary required to support these activities. ..
  22. Vaccine responsiveness to Borrelia burgdorferi OspA
    Richard Flavell; Fiscal Year: 2007
    ..abstract_text> ..
  23. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2007
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  24. Genomics of Susceptibility to Urinary Tract Infections
    WALTER HOPKINS; Fiscal Year: 2007
    ..coli strains or non-E, coil bacteria. These objectives will be accomplished using a well-established mouse model of ascending UTI, genetic linkage analysis, and evaluation of resistance to uropathogens in congenic mice. ..
  25. The Novel Role for Adenosine Receptor Agonists in Acquired Neonatal Tolerance
    Peter Ernst; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Genetic Determinants of A. Fumigatus Susceptibility
    Aimee Zaas; Fiscal Year: 2008
    ..fumigatus infection, this proposal will identify and characterize genetic polymorphisms related to IA susceptibility in mice and validate these findings in a cohort of human bone marrow transplant donors and recipients. ..
  27. Role of E. coli Virulence Factors in Chronic Prostate Infection and Inflammation
    WALTER HOPKINS; Fiscal Year: 2008
    ..coli genes play a direct or indirect role in development of prostatic lesions. Results of these studies can lead to new methods to prevent or treat chronic bacterial prostatitis. [unreadable] [unreadable] [unreadable]..
  28. Roles of Nod2 in the Pathogenesis of Crohn's Disease
    Richard Flavell; Fiscal Year: 2008
    ..Furthermore, by using mice in which Rip2, the kinase downstream of Nod2, is deficient, we will try to reveal if the IBD pathology caused by Nod2 mutation is dependent on Rip2. [unreadable] [unreadable]..
  29. BECTON DICKINSON FACS CALIBUR 4 COLOR WITH SORT UNIT
    Kenneth Pollard; Fiscal Year: 2001
    ..Flow cytometry will be used to select and sort cell populations prior to and after transplantation studies. ..
  30. The Role of Adenosine Receptors in Th Cell Development and Function
    Peter Ernst; Fiscal Year: 2008
    ..abstract_text> ..
  31. Thymocyte tuning after selection: mechanisms to avoid autoreactivity
    Terri M Laufer; Fiscal Year: 2010
    ..These experiments will define the mechanisms which regulate a critical thymic pathway that the immune system utilizes to avoid autoreactivity. ..
  32. DC-CD4 interactions in Th2 differentiation
    Terri Laufer; Fiscal Year: 2006
    ..abstract_text> ..
  33. Cytokine Responses to H. pylori Infection, Immunization
    Peter Ernst; Fiscal Year: 2006
    ..pylori infection. 2). Identify T cell markers that are correlates of immunity. 3). Define mechanisms of host defense attributed to "protective" Th cells. ..
  34. Regulatory T Cell Selection and Specificity
    CALVIN B contact WILLIAMS; Fiscal Year: 2010
    ..abstract_text> ..
  35. Calcium for Prevention of Postpartum Depression
    Daniel Hatton; Fiscal Year: 2004
    ..A significantly smaller proportion in the calcium group will be taken as evidence in support of the hypothesis. Positive results from this trial will provide a strong foundation for a multicenter intervention trial. ..
  36. SICKLE RBC, INTERMITTENT HYPOXIA AND VASCULAR PATHOLOGY
    FRANS KUYPERS; Fiscal Year: 2003
    ..Together, our results may indicate novel treatment regiments in the management of SCD. ..
  37. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
    ..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
  38. PRODUCTION AND SCREENING OF MOUSE NEUROLOGICAL MUTATIONS
    WAYNE FRANKEL; Fiscal Year: 2004
    ..Our goal is to maximize the number of neurological mutants that become important research tools. ..
  39. SELECTION AND SURVIVAL OF T LYMPHOCYTES
    CALVIN WILLIAMS; Fiscal Year: 2004
    ..Progress in the experimental and therapeutic approach to autoimmune inflammation hinges upon elucidation of the factors which select and maintain the peripheral T cell repertoire. ..
  40. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2003
    ..abstract_text> ..
  41. Dys/Regulation of the Immune System in Autoimmunity
    Richard Flavell; Fiscal Year: 2006
    ..The program is coordinated by frequent meetings of the program faculty and research workers bringing together these diverse approaches to address a common goal. ..
  42. JAX Neurogenetics Conference
    WAYNE FRANKEL; Fiscal Year: 2004
    ..This meeting has been held every two years since 1994 and continues to be unique with respect to size, focus and format. ..
  43. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2004
    ..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
  44. Protective Role of Mrp2 During Chemotherapy-Induced Kidney Injury
    LAUREN ALEKSUNES; Fiscal Year: 2008
    ..Furthermore, these studies will contribute to our understanding of the adaptive mechanisms that occur within the kidneys in response to drug toxicity. [unreadable] [unreadable]..
  45. Characterization of the Murine pcy Mutation
    David Woo; Fiscal Year: 2005
    ..abstract_text> ..
  46. The pathobiology of gastrointestinal disease in mice
    Peter Ernst; Fiscal Year: 2005
    ....
  47. URINARY TRACT INFECTIONS--IMMUNE BASIS OF SUSCEPTIBILITY
    WALTER HOPKINS; Fiscal Year: 2003
    ....
  48. Education Program for Digestive Health Research
    Peter Ernst; Fiscal Year: 2008
    ..The trainees will be exposed to an enjoyable experience and long-term personal contacts that will be influential in encouraging them to pursue a career in biomedical research that will improve digestive health. ..
  49. GENETIC DISSECTION OF AGGRESSIVE BEHAVIORS
    EDWARD BRODKIN; Fiscal Year: 2007
    ..Dr. Wade Berrettini will be the mentor, and Drs. Maja Bucan, Russell Buono, Thomas Ferraro, and Irwin Lucki will provide additional consultation in genetics and behavioral analysis. ..
  50. T cell diversity in the induction of autoimmunity
    Terri Laufer; Fiscal Year: 2006
    ..Understanding the requirements for T cell diversity and the interactions between "graft" T cells and host antigen presenting cells offers improved immunologic targets for preventing GVHD following bone marrow transplant. ..
  51. PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPY
    THOMAS FERRARO; Fiscal Year: 2003
    ....
  52. The Role of IL-2 in Autoimmune Diabetes
    Richard Flavell; Fiscal Year: 2007
    ..We will utilize our IL-2 knock-in mice to test these two mutually nonexclusive hypotheses. ..
  53. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006
    ..The proposed experiments will identify genes expressed in gonadal SSCs that play a role in gonadal XY sex reversal. ..