- Characterization of peripheral circadian clocks in adipose tissues
Stem Cell Laboratory, Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, LA, USA
Diabetes 55:962-70. 2006
- Senescence-accelerated mouse (SAM): a novel murine model of senescence
Department of Senescence Biology, Kyoto University, Japan
Exp Gerontol 32:105-9. 1997
..The genetic background and significance of SAM development are discussed...
- Absence of CC chemokine ligand 2 results in an altered Th1/Th2 cytokine balance and failure to expel Trichuris muris infection
Matthew L deSchoolmeester
Department of Immunology, Microbiology, and Development, University of Manchester School of Biological Sciences, Manchester, United Kingdom
J Immunol 170:4693-700. 2003
..Elevated levels of IL-12 are produced by polarizing APCs, and the composition of the APC environment itself is perturbed, with reduced numbers of macrophages...
- Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
Alexander M Owyang
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Exp Med 203:843-9. 2006
..Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract...
- RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:13596-600. 2004
..Together, these results suggest that intestinal goblet cell-derived RELMbeta may be a novel Th2 cytokine-induced immune-effector molecule in resistance to GI nematode infection...
- B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris
N M Blackwell
School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
Infect Immun 69:3860-8. 2001
..Our results as a whole describe the first detailed report of a critical role for B cells in resistance to an intestinal nematode...
- Blockade of PSGL-1 attenuates CD14+ monocytic cell recruitment in intestinal mucosa and ameliorates ileitis in SAMP1/Yit mice
National Defense Medical College, 2 3 Namiki, Tokorozawa, Saitama 359 8513, Japan
J Leukoc Biol 77:287-95. 2005
- Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma
C L Karp
Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MA, USA
Nat Immunol 1:221-6. 2000
..The role of complement in modulating susceptibility to asthma highlights the importance of immunoregulatory events at the interface of innate and adaptive immunity in disease pathogenesis...
- Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
M M Kosiewicz
Departments of Medicine and Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Invest 107:695-702. 2001
..To our knowledge, these data provide the first direct evidence that Th1-producing T cells mediate intestinal inflammation in a spontaneous animal model of human Crohn's disease...
- Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
Timothy S Olson
Department of Molecular Physiology and Cardiovascular Research Center, University of Virginia Health Science Center, Charlottesville 22908, USA
J Clin Invest 114:389-98. 2004
..SAMP1/YitFc B cells prevent alpha(E)beta(7)(+)CD4(+) T cells from suppressing effector T cell proliferation. We conclude that SAMP1/YitFc MLN B cells contribute to the development of SAMP1/YitFc ileitis...
- L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine
Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Immunol 174:2343-52. 2005
..Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine...
- Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
Infect Immun 73:4025-33. 2005
- The characterization of intraepithelial lymphocytes, lamina propria leukocytes, and isolated lymphoid follicles in the large intestine of mice infected with the intestinal nematode parasite Trichuris muris
Matthew C Little
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
J Immunol 175:6713-22. 2005
..Furthermore, we demonstrate the organogenesis of these structures in response to T. muris infection...
- Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc
Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Gastroenterology 125:477-90. 2003
..We performed a genetic analysis of a (B6 x SAMP1/Fc)F(2) cross to localize the genes regulating intestinal inflammation in this model...
- The development of a highly informative mouse Simple Sequence Length Polymorphism (SSLP) marker set and construction of a mouse family tree using parsimony analysis
Philip D Witmer
Center for Inherited Disease Research CIDR, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Genome Res 13:485-91. 2003
..With this large data set, we sought to reconstruct a phylogenetic history of the laboratory mouse using Wagner parsimony analysis. Our results are largely congruent with the known history of inbred mouse strains...
- The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics
Sonya G Wilson
Department of Psychology and Program in Neuroscience, University of Illinois at Urbana Champaign, Champaign, Illinois, USA
J Pharmacol Exp Ther 304:547-59. 2003
..However, the genes in question may affect antinociception indirectly, via a primary action on baseline nociceptive sensitivity...
- Interaction of the nicotinic cholinergic system with ethanol withdrawal
Christopher M Butt
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
J Pharmacol Exp Ther 308:591-9. 2004
..These results suggest that the nicotinic cholinergic system and the A/T polymorphism modulate ethanol withdrawal...
- Genetic determinants of sensitivity to pentobarbital in inbred mice
John C Crabbe
Department of Behavioral Neuroscience, VA Medical Center, Oregon Health and Science University, Portland, OR 97201, USA
Psychopharmacology (Berl) 161:408-16. 2002
..We postulated that genetic determinants of different responses to pentobarbital (PB) in mice would differ from response to response...
- Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice
P E Thomas
Genetics 74:655-9. 1973
..Genetic analyses and strain surveys indicate that the In and Ahh loci are identical, or very closely linked...
- In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice
Jonathan D Smith
Rockefeller University, New York, NY, USA
Arterioscler Thromb Vasc Biol 23:117-22. 2003
- Antibody to soluble 1,3/1,6-beta-D-glucan, SCG in sera of naive DBA/2 mice
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Biol Pharm Bull 26:1225-8. 2003
..These results suggested that DBA/1 and DBA/2 strains carry specific and unique immunological characteristics to branched 1,3-/1,6-beta-glucan...
- Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci
J R Robinson
J Biol Chem 249:5851-9. 1974
- Structural polymorphism of murine complement factor H controlled by a locus located between the Hc and the beta 2M locus on the second chromosome of the mouse
J Immunol 134:2600-6. 1985
..This was shown by phenotyping the Hc locus and H locus with backcross progenies between A/J (one of strain with H.1) and MoA (one of strain with H.2). The recombination frequency between these two loci was 0.17 +/- 0.046...
- T cell receptor-gamma allele-specific selection of V gamma 1/V delta 4 cells in the intestinal epithelium
Unité du Développement des Lymphocytes, Center National de la Recherche Scientifique, Unite de Recherche Associee, Institut Pasteur, Paris, France
J Immunol 169:3736-43. 2002
- In vivo priming of mouse CTL precursors directed to product of a newly defined minor H-42 locus is under a novel control of class II MHC gene
J Immunol 135:3681-5. 1985
- Application of inter-simple sequence repeat PCR to mouse models: assessment of genetic alterations in carcinogenesis
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Genes Chromosomes Cancer 35:299-310. 2002
..These PCR-based fingerprints provide a novel approach to assessing the number and onset of mutational events in mouse tumors and will help to understand better the mechanisms of carcinogenesis in mouse models...
- Mechanisms of enhanced macrophage-mediated prostaglandin E2 production and its suppressive role in Th1 activation in Th2-dominant BALB/c mice
Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
J Immunol 170:757-64. 2003
- A new lymphocyte cell surface antigen, Ly-22.2, controlled by a locus on chromosome 4 and a second unlinked locus
J Immunol 130:946-50. 1983
..Strain distribution studies show Ly-22.2 is present in all strains examined except B10-derived congenic strains. It is of interest that C57BL/6 and C57BL/10 mice differ in the expression of this antigen...
- Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG)
J Immunol 131:1966-72. 1983
- Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence
Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, 10314, USA
Neuroscience 115:463-9. 2002
..The data also demonstrate that the differential genetic liability to morphine physical dependence begins with, and is predicted by, the first morphine exposure...
- The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles
Institut Armand Frappier, Universite du Quebec, Laval, Canada
Int Immunol 9:533-40. 1997
..Together with our and others previous observations, these results identify the NK2.1/Ly-49C antigen as a receptor for MHC class I molecules whose expression is regulated by host MHC genes...
- Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes
Institute of Clinical Microbiology and Immunology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
J Exp Med 186:1419-29. 1997
..These findings suggest that the altered ligand binding behavior of the newly described IL-4R allotype may influence the IL-4 responsiveness, thus contributing to the diverse phenotypes of inbred mouse strains in IL-4-dependent diseases...
- The mouse intracisternal A particle-promoted placental gene retrotransposition is mouse-strain-specific
Department of Biology, Johns Hopkins University, Baltimore, MD 21218
Proc Natl Acad Sci U S A 90:292-6. 1993
..The symbol Ipp is being used for this gene in all major mouse data bases and in the comparative section of the human genome data base...
- Studies on natural killer (NK) cells. I. NK cell specific antibodies in CE anti-CBA serum
R C Burton
J Immunol 126:1985-9. 1981
..2, and the corresponding antibodies as anti-NK-1.2. However, the possibility that CE anti-CBA serum detects a new system of NK-specific antigen has not been excluded...
- Polygenic control of the immune response to F antigen
D M Silver
Immunogenetics 12:237-51. 1981
..Such complex genetic control suggests regulation by a number of independently segregating loci whose function it is to limit the autoimmune response to F antigen...
- Ly 9, an alloantigenic marker of lymphocyte differentiation
B J Mathieson
J Immunol 125:2127-36. 1980
..Cytotoxic elimination experiments confirm that Ly 9 is expressed on at least 2 different T cell functional subsets and B cells...
- Definition of a new T lymphocyte cell surface antigen, Ly 11.2
J Immunol 125:2713-8. 1980
..Although the locus coding for this antigen appears to be closely linked to the minor histocompatibility locus H-30 and to the locus coding for Ly 6.2, a chromosome assignment has not yet been made for my of these loci...
- Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice
J Immunol 127:2417-21. 1981
..The product of the Bcg gene was found to influence the early phase of host response resulting in the genetic advantage of the resistant host being demonstrable as early as 24 hr after infection...
- Mouse strain variation in maximal electroshock seizure threshold
Thomas N Ferraro
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
Brain Res 936:82-6. 2002
..We conclude that MEST represents a useful tool for dissecting the multifactorial nature of seizure sensitivity in mice...
- Evidence for a new lymphocyte-stimulating determinant (Lsd) detected by alloreactive T cell lines
Eur J Immunol 13:24-30. 1983
..BR anti-C57BL/10). The third clone (BD7, C57BL/6 anti-CBA/J) was probably originally directed against Lsd. So far, Lsd is only characterized by stimulation of T cell proliferation, and its physiological function is not yet known...
- H-41, a new minor histocompatibility locus. I. Histogenetic analysis
J Immunol 133:2950-4. 1984
..The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain...
- Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity
William R Lariviere
Department of Psychology and Neuroscience Program, University of Illinois at Urbana Champaign, IL 61820, USA
Pain 97:75-86. 2002
- Control of mouse hepatitis virus replication in macrophages by a recessive gene on chromosome 7
M S Smith
J Immunol 133:428-32. 1984
..We have identified and mapped a new locus that imparts resistance to productive infection of mouse hepatitis virus MHV(A59) in cultured macrophages. This locus maps 41.5 centimorgans from the albino locus on chromosome 7...
- Cell-mediated cytotoxicity to non-MHC alloantigens on mouse epidermal cells. I. H-2 restricted reactions among strains sharing the H-2k haplotype
J Immunol 126:1747-53. 1981
- Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate concentration (Gtpc) to mouse chromosome 9
J P Jenuth
Department of Paediatrics, Faculty of Medicine, University of Calgary, Canada
Genome 37:399-404. 1994
..A test for linkage of Gtpc to transferrin (Trf) on chromosome 9 gave evidence of linkage with an observed recombination frequency of 14.6 +/- 5.5 and a 99% confidence interval of 3.9-33.9 cM...
- Linkage of a 7S RNA sequence and kappa light chain genes in the mouse
B A Taylor
Immunogenetics 22:471-81. 1985
..The Rn7s-6 variant is a plus/minus variant; no sequence allelic to Rn7s-6 is found in inbred strains that share the Ly-3a-Igk-Ef1a haplotype...
- Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus
D M Gibson
J Immunol 121:1585-90. 1978
..6 map units) to the Ly-2,3 locus on mouse Chromosome 6. The locus controlling normal light chain IF-patterns has been designated Ef1...
- In vivo hydrodynamic delivery of cDNA encoding IL-2: rapid, sustained redistribution, activation of mouse NK cells, and therapeutic potential in the absence of NKT cells
John R Ortaldo
Laboratory of Experimental Immunology, National Cancer Institute Center for Cancer Research, Frederick, MD 21702, USA
J Immunol 175:693-9. 2005
- Chronic pain and genetic background interact and influence opioid analgesia, tolerance, and physical dependence
De Yong Liang
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
Pain 121:232-40. 2006
..We conclude that chronic inflammatory pain and genetics interact to modulate the analgesic potency of morphine, tolerance, and physical dependence...
- Inherited immunoglobulin idiotypes of the mouse
Immunol Rev 34:119-38. 1977
- Mice with blunted hypoxic ventilatory response are susceptible to respiratory disturbance during hypoxia
Department of Cardiovascular and Respiratory Medicine, Tohoku University School of Medicine, Kawauchi 41, Sendai 980 8576, Japan
Tohoku J Exp Med 209:125-34. 2006
..We suggest that a lower hypoxic ventilatory response may be a risk factor for apnea under hypoxia...
- Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification
Medizinische Klinik II, University of Luebeck, Luebeck, Germany
Physiol Genomics 28:203-12. 2007
..T153I changes might affect the biological function of EMP-3 gene product after injury. Using this combined approach, we ultrafine-mapped the Dyscalc1 locus to an 80-Kb region and identified EMP-3 as a new candidate gene for DCC...
- Sleep and temperature responses of inbred mice with Candida albicans-induced pyelonephritis
Linda A Toth
Southern Illinois University School of Medicine, Springfield, Illinois, USA
Comp Med 56:252-61. 2006
..C. albicans-infected mice may be a useful model for identifying the genes and mechanisms that link sleep, temperature, fatigue, and the immune response...
- Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis
Department of Senescence Biology, Kyoto University, Japan
Biochem J 279:427-33. 1991
..The molecular type of apoA-II may be a factor involved in the development of senile amyloidosis in mice...
- Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
Jessica J Nadler
Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599 7264, USA
Genetics 174:1229-36. 2006
..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
- The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study
Schering AG, Müllerstr 178, 13342 Berlin, Germany
Reprod Biol Endocrinol 5:1. 2007
..To gain more insight into this species difference we have now evaluated the reproductive effects of miglustat in rabbits, in multiple mouse strains and in interstrain hybrid mice...
- Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis
Stefan M Muehlbauer
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Cycle 6:758-66. 2007
..We propose that caspase-1-mediated macrophage necrosis is the source of the cytokine storm and rapid disease progression reported in LT-treated BALB/c mice...
- The location of the C3 and GLO (glyoxalase 1) loci of the IXth linkage group in mice
J Immunol 122:2584-9. 1979
- Enhancer elements in the mouse CYP1A2 gene: a comparative sequencing among different inbred mouse strains
Olga N Mikhailova
Institute of Molecular Biology and Biophysics, Novosibirsk 630117, Russia
Mutat Res 632:99-103. 2007
..The absence of mutation prescribing the phenotype in the CYP1A2 gene was found. The region studied seems to be a highly conserved in mice and not to be associated with interstrain differences in constitutive CYP1A2 enzyme activity...
- Significant gene content variation characterizes the genomes of inbred mouse strains
Lead Discovery, Amgen, South San Francisco, California 94080, USA
Genome Res 17:1743-54. 2007
..Using a whole-genome association analysis, we demonstrate that complex multigenic phenotypes, such as food intake, can be associated with specific copy number changes...
- Idiotypic analysis of the response of C57BL/6 mice to the (4-hydroxy-3-nitrophenyl)acetyl group
R S Jack
Eur J Immunol 7:559-65. 1977
..Breeding experiments demonstrated that the marker segregated with the heavy chain linkage group...
- Plasminogen alleles influence susceptibility to invasive aspergillosis
Aimee K Zaas
Duke University Medical Center, Durham, North Carolina, United States of America
PLoS Genet 4:e1000101. 2008
..Furthermore, we demonstrated that plasminogen directly binds to Aspergillus fumigatus. We propose that genetic variation within the plasminogen pathway influences the pathogenesis of this invasive fungal infection...
- Genetic influence on daily wheel running activity level
J Timothy Lightfoot
Department of Kinesiology, University of North Carolina Charlotte, Charlotte 28223, USA
Physiol Genomics 19:270-6. 2004
..In conclusion, these data indicate that daily running wheel activity level in mice is significantly affected by genetic background and sex...
- Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450
D W Nebert
Mol Pharmacol 8:651-66. 1972
- An Eco RI restriction length polymorphism at the murine L-myc locus
I Centro di Riferimento Oncologico, Aviano, Italy
Nucleic Acids Res 16:11853. 1988
- Mapping blood pressure loci in (A/J x B6)F2 mice
David D L Woo
David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Physiol Genomics 15:236-42. 2003
..Defining the molecular differences between the A/J and the B6 alleles at these novel loci with major influences on the BP phenotype will contribute to our understanding of the complex genetics of BP control...
- Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
M L Mucenski
NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
Oncogene Res 2:219-33. 1988
..These results suggest that Evi-1 represents a new locus involved in myeloid disease...
- Electroretinography as a screening method for mutations causing retinal dysfunction in mice
GSF National Research Center for Environment and Health, Institutes of Developmental Genetics, Clinical Cooperation Group Ophthalmogenetics, Neuherberg, Germany
Invest Ophthalmol Vis Sci 45:601-9. 2004
..To detect mice with hereditary retinal impairment, a high-throughput electroretinography (ERG) screening system was established...
- Genotype-dependence of gabapentin and pregabalin sensitivity: the pharmacogenetic mediation of analgesia is specific to the type of pain being inhibited
Elissa J Chesler
Department of Psychology and Neuroscience Program, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
Pain 106:325-35. 2003
..This has considerable implications for ongoing pharmacogenetic investigations and, more generally, for the choices of preclinical models of pain used in drug development...
- Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiation
Department of Experimental Pathology, John Curtin School of Medical Research, Canberra, Australia
Eur J Immunol 19:223-9. 1989
..Expression of Ly-24 by thymocytes is discussed in the context of current models of intrathymic T cell differentiation...
- Strain distribution pattern of susceptibility to immune-mediated nephritis
Simmons Arthritis Research Center, Division of Rheumatology, Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Immunol 172:5047-55. 2004
..Detailed studies to dissect out the immunological and genetic basis of renal disease in these three strains are clearly warranted...
- Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis
Amol S Rangnekar
Department of Medicine, Division of Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Liver Int 26:1000-5. 2006
- Restriction fragment analysis of V preB and lambda 5 within the genus Mus
L A D'Hoostelaere
Basel Institute for Immunology, Switzerland
Eur J Immunol 19:37-42. 1989
..These results suggest that V preB1, V preB2 and lambda 5 have been present for over 12 million years...
- A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14
Laboratory of Genetics, NCI, Bethesda, MD 20892
Nucleic Acids Res 17:2881. 1989
- Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model-end of 1971
H E Skipper
Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, AL, USA
Cancer Chemother Rep 56:273-87, 289-314. 1972
- Infection of central nervous system cells by ecotropic murine leukemia virus in C58 and AKR mice and in in utero-infected CE/J mice predisposes mice to paralytic infection by lactate dehydrogenase-elevating virus
G W Anderson
Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455 0312
J Virol 69:308-19. 1995
- Anticancer potential of Viva-Natural, a dietary seaweed extract, on Lewis lung carcinoma in comparison with chemical immunomodulators and on cyclosporine-accelerated AKR leukemia
Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu
Oncology 46:343-8. 1989
..Viva-Natural reversed the potentiation effect of ciclosporin on the development of leukemia in AKR mice at preleukemic stage...
- Age-dependent poliomyelitis of mice: expression of endogenous retrovirus correlates with cytocidal replication of lactate dehydrogenase-elevating virus in motor neurons
C H Contag
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455 0312
J Virol 63:4362-9. 1989
..We discuss potential mechanisms for the novel dual-virus etiology of age-dependent poliomyelitis of mice...
- Oncogenicity of AKR mink cell focus-inducing murine leukemia virus correlates with induction of chronic phosphatidylinositol signal transduction
A M al Salameh
Department of Microbiology, University of Texas Medical Branch, Galveston 77550
J Virol 66:6125-32. 1992
..g., ras and fms). Its chronic induction by oncogenic MCF MuLV may thus initiate thymocyte transformation...
- Loss of pathogenicity of spleen focus-forming virus after pseudotyping with Akv
K S Jones
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
J Virol 62:511-8. 1988
..Thus, the helper virus used to rescue SFFV plays at least a quantitatively important role in the early stage of FV disease and a crucial role in the late stage of the disease in vivo...
- A single point mutation in the envelope gene is responsible for replication and XC fusion deficiency of the endogenous ecotropic C3H/He murine leukemia virus and for its repair in culture
Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701
J Virol 62:932-43. 1988
- Effect of pretazettine and viva-natural, a dietary seaweed extract, on spontaneous AKR leukemia in comparison with standard drugs
Department of Pharmacology, John A Burns School of Medicine, University of Hawaii, Honolulu
Oncology 45:180-6. 1988
..Also, PTZ has been found to reverse the leukemia-enhancing effect of ciclosporin in AKR mice at preleukemic stage...
- Potential progenitor sequences of mink cell focus-forming (MCF) murine leukemia viruses: ecotropic, xenotropic, and MCF-related viral RNAs are detected concurrently in thymus tissues of AKR mice
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
J Virol 62:376-86. 1988
..We have also described the unique structure of the 6.0-kb MCF-related RNAs which were expressed specifically in liver and kidney tissues of AKR mice; these RNAs contained an upstream non-MuLV transcriptional regulatory element...
- Termination of the B cell lymphoma dormant state in thymectomized AKR mice
N Haran Ghera
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
J Immunol 148:2947-52. 1992
..These results suggest that T cell subsets and/or their products are involved in the proliferation arrest of potential lymphoma cells present in thymectomized AKR mice...
- Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine: I. Activation of natural killer cells in mice
B S Sharma
Department of Immunology, ICN Pharmaceuticals, Costa Mesa, CA 92626
Immunopharmacol Immunotoxicol 14:1-19. 1992
..Low concentrations of IL-2 (0.25-5 U/ml) that induce little or no NK cell activity, when used in combination with 7T8OG, elicited significant enhancement of NK cell cytotoxicity. In contrast, IFN and 7T8OG showed no such synergism...
- The occurrence of vacuolation, and periodic acid-Schiff (PAS)-positive granules and plaques in the brains of C57BL/6J, AKR, senescence-prone (SAMP8) and senescence-resistant (SAMR1) mice infected with various scrapie strains
Department of Virology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Brain Res 995:158-66. 2004
..These findings suggest that PGS accumulation was more dependent on the genetic information of the mouse strain, whereas PP and vacuolation patterns depended on the scrapie strain-mouse strain combination...
- Allelic differences in TCR gamma-chains alter gamma delta T cell antigen reactivity
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
J Immunol 153:1455-65. 1994
..We propose that amino acid differences among those encoded by the AKR V gamma 1-J gamma 4-C gamma 4 gene are responsible for the lack of response, and reduce the ability of the TCR-gamma delta to bind the relevant Ag...
- A direct demonstration of recombination between an injected virus and endogenous viral sequences, resulting in the generation of mink cell focus-inducing viruses in AKR mice
N L DiFronzo
Center for Virology, Children s National Medical Center, Washington, DC 20010 2970
J Virol 67:3763-70. 1993
..Furthermore, the progression to leukemia was accelerated in mice that develop tumors containing proviruses with an MCF virus env gene, emphasizing the importance of the role of the MCF virus env gene product in transformation...
- Replication of lactate dehydrogenase-elevating virus in cells infected with murine leukaemia viruses in vitro
Central Virus Diagnostic Laboratory, National Institute of Health, Tokyo, Japan
J Gen Virol 72:2437-44. 1991
..These results may be relevant to the mechanisms of paralytic disease caused by LDV infection in C58 mice...
- Amelioration of acute graft-versus-host disease and re-establishment of tolerance by short-term treatment with an anti-TCR antibody
Department of Immunology, Kyushu University, Fukuoka, Japan
J Immunol 153:4311-20. 1994
..Collectively, these data indicate that a short-term treatment of mice having GVHD with an anti-TCR-alpha beta mAb, starting even after disease onset, can re-establish host-specific tolerance, at least to the host-histo-compatibility Ag...
- Differential cell killing by lymphomagenic murine leukemia viruses occurs independently of p53 activation and mitochondrial damage
Department of Immunology and Microbiology and the Karmanos Cancer Institute, Wayne State University, 540 E Canfield Avenue, Detroit, MI 48201, USA
J Virol 78:5088-96. 2004
..These results demonstrate that MCF13 MLV induces apoptosis preferentially in cells in which superinfection occurs, and the mechanism involved is independent of p53 activation and mitochondrial damage...
- Importance of suppressor T cells in cyclophosphamide-induced tolerance to the non-H-2-encoded alloantigens. Is mixed chimerism really required in maintaining a skin allograft tolerance?
Department of Immunology, Kyushu University Fukuoka, Japan
J Immunol 144:463-73. 1990
..Moreover, the generation of the Ts cells does not necessarily require the establishment of a long term mixed chimeric state...
- Coexistence in lactate dehydrogenase-elevating virus pools of variants that differ in neuropathogenicity and ability to establish a persistent infection
Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455, USA
J Virol 71:2913-20. 1997
..30-amino-acid ectodomain of VP-3P, which seems to carry the neutralization epitope(s) and forms part of the virus receptor attachment site...
- Lactate dehydrogenase-elevating virus variants: cosegregation of neuropathogenicity and impaired capability for high viremic persistent infection
University of Minnesota, Department of Microbiology, Minneapolis 55455, USA
J Neurovirol 4:560-8. 1998
..The only consistent and biologically relevant molecular difference we have observed between neuropathogenic and non-neuropathogenic LDVs is the number of polylactosaminoglycan chains associated with the ectodomain of VP-3P...
- Cycloheximide increases endogenous retroviral RNA levels in murine liver and lung
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan. Italy
Tumori 75:217-21. 1989
..The strains genetically resistant to lung carcinogenesis (C3Hf, C57BL/6J) showed higher lung basal levels and higher cycloheximide inducibility of mRNAs homologous to Mo-MuLV than the susceptible strains (A/J, BALB/c)...
- Characterisation of the protective immune response following subcutaneous vaccination of susceptible mice against Trichuris muris
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
Int J Parasitol 40:683-93. 2010
..High levels of serum IgG1 and cell-bound IgG1 in the colon of mice protected by the ES/IFA vaccine suggest that antibody may be involved in vaccination-induced worm expulsion...
- Abnormalities in the cerebellum and brainstem in homozygous lurcher mice
Laboratoire d Histologie, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
Neuroscience 80:175-90. 1997
..Lastly, they confirm the absence of effect of the mutation on the neurons of the inferior olivary complex...
- Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile
D Q Wang
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, and Harvard Digestive Diseases Center, Boston, MA 02115, USA
J Lipid Res 38:1395-411. 1997
..iii) Mucin gel accumulation, crystallization, and stone formation are rare in AKR mice. This definition of the physical chemistry of lithogenesis should aid in further elucidation of the Lith genes and the proteins they encode...
- Selective antibody neutralization prevents neuropathogenic lactate dehydrogenase-elevating virus from causing paralytic disease in immunocompetent mice
University of Minnesota, Department of Microbiology, Minneapolis 55455, USA
J Neurovirol 5:200-8. 1999
- The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3
Marc Andre Langlois
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom CB2 0QH
J Virol 83:11550-9. 2009
- Genetic and immunological factors interact in a mouse model of CNS antiphospholipid syndrome
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
Behav Brain Res 169:289-93. 2006
..Qualitative differences in behavioral patterns may be due to nervous system as well as immune genetic factors. The minimal effect of APS in C57BL/6 mice may provide a suitable background for the study of transgenes in these mice...