Genomes and Genes
Summary: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannas of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Publications248 found, 100 shown here
- Roles for endocytosis and low pH in herpes simplex virus entry into HeLa and Chinese hamster ovary cellsAnthony V Nicola
Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:5324-32. 2003..The results suggest that HSV can utilize two distinct entry pathways, depending on the type of cell encountered...
- Identification and characterization of a cross-neutralization epitope of Enterovirus 71Chia Chyi Liu
Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
Vaccine 29:4362-72. 2011..Thus, VP2-28 could be used as the surrogate biomarker in the potency testing of candidate EV71 vaccines...
- Bats are natural reservoirs of SARS-like coronavirusesWendong Li
Institute of Zoology, Chinese Academy of Sciences CAS, Beijing, China
Science 310:676-9. 2005..The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group...
- Mechanisms determining the morphology of the peripheral ERYoko Shibata
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 143:774-88. 2010..These proteins may generate sheets by stabilizing the high curvature of edges...
- Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infectionKartik Chandran
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Science 308:1643-5. 2005..CatB and CatB/CatL inhibitors diminish the multiplication of infectious EboV-Zaire in cultured cells and may merit investigation as anti-EboV drugs...
- Peroxisomes are signaling platforms for antiviral innate immunityEvelyn Dixit
Division of Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Cell 141:668-81. 2010..The interferon regulatory factor IRF1 plays a crucial role in regulating MAVS-dependent signaling from peroxisomes. These results establish that peroxisomes are an important site of antiviral signal transduction...
- Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor systemChia Chyi Liu
Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
PLoS ONE 6:e20005. 2011..Enterovirus 71 (EV71) infections manifest most commonly as a childhood exanthema known as hand-foot-and-mouth disease (HFMD) and can cause neurological disease during acute infection...
- Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor familyR I Montgomery
Northwestern University Medical School, Department of Microbiology Immunology, Chicago, Illinois 60611, USA
Cell 87:427-36. 1996..The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells. HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family...
- Role of endosomal cathepsins in entry mediated by the Ebola virus glycoproteinKathryn Schornberg
Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
J Virol 80:4174-8. 2006..These and other results support a model in which CatB and CatL prime GP by generating a 19-kDa intermediate that can be acted upon by an as yet unidentified endosomal/lysosomal enzyme to trigger fusion...
- Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cellsW D Crill
Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
J Virol 75:7769-73. 2001..These results extend our understanding of the structure-function relationships in the E glycoprotein of DEN virus and provide the first direct evidence that domain III encodes the primary flavivirus receptor-binding motif...
- Selection and characterization of vaccine strain for Enterovirus 71 vaccine developmentJui Yuan Chang
Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Township, Miaoli County 350, Taiwan
Vaccine 30:703-11. 2012..Therefore, these results provide valuable information for cell-based EV71 vaccine development...
- The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complexLeah K Gillespie
Department of Microbiology, La Trobe University, Bundoora, Melbourne 3086, Australia
J Virol 84:10438-47. 2010..In addition, we provide data that indicate that a majority of the viral RNA species housed within the RC is in a double-stranded RNA (dsRNA) form...
- Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migrationTakashi Watanabe
Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
Dev Cell 7:871-83. 2004....
- Inhibition of interferon signaling by dengue virusJorge L Munoz-Jordan
Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029
Proc Natl Acad Sci U S A 100:14333-8. 2003..This protein, encoded by a positive strand RNA virus, is implicated as an IFN-signaling inhibitor...
- Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporterDavid Dingli
Molecular Medicine Program, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Blood 103:1641-6. 2004..Testing in other radiosensitive cancers is warranted...
- Multicolor super-resolution imaging with photo-switchable fluorescent probesMark Bates
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Science 317:1749-53. 2007..Using this approach, we demonstrate multicolor imaging of DNA model samples and mammalian cells with 20- to 30-nanometer resolution. This technique will facilitate direct visualization of molecular interactions at the nanometer scale...
- MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decayGeorg Stoecklin
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
EMBO J 23:1313-24. 2004..Our data reveal the mechanism by which the p38-MAPK/MK2 kinase cascade inhibits TTP-mediated degradation of ARE-containing transcripts and thereby contributes to lipopolysaccharide-induced TNFalpha expression...
- Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1PWinfried R Beyer
Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, D 20251 Hamburg, Germany
J Virol 77:2866-72. 2003..In agreement with the identified consensus motif, we show that the cellular subtilase SKI-1/S1P cleaves LCMV GP...
- Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infectionJose I Quetglas
Departamento de Biotecnologia Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, INIA, Madrid, Spain
J Virol 86:1758-67. 2012....
- Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopesWayne D Crill
Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, P O Box 2087, Fort Collins, CO 80522, USA
J Virol 78:13975-86. 2004..The third epitope consists of discontinuous residues that are structurally related to the strictly conserved tryptophan at dengue virus serotype 2 E-glycoprotein position 231...
- Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMCV Stalin Raj
Department of Viroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
Nature 495:251-4. 2013..In addition, it will contribute critically to our understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies...
- Subdiffraction-resolution fluorescence imaging with conventional fluorescent probesMike Heilemann
Angewandte Laserphysik and Laserspektroskopie, Universitat Bielefeld, Universitatsstrasse 25, 33615 Bielefeld, Germany
Angew Chem Int Ed Engl 47:6172-6. 2008
- Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cellsOleg O Glebov
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nat Cell Biol 8:46-54. 2006..We propose that flotillin-1 is one determinant of a clathrin-independent endocytic pathway in mammalian cells...
- Dengue virus ensures its fusion in late endosomes using compartment-specific lipidsElena Zaitseva
Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 6:e1001131. 2010....
- Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent mannerAsuka Nanbo
Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS Pathog 6:e1001121. 2010..These findings provide new insights into the lifecycle of Ebolavirus and may aid in the development of therapeutics for Ebolavirus infection...
- The small RING finger protein Z drives arenavirus budding: implications for antiviral strategiesMar Perez
Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:12978-83. 2003..Moreover, members of the vacuolar protein sorting pathway appear to play an important role in arena-virus budding. These findings open possibilities for antiviral strategies to combat LFV and other hemorrhagic fever arenaviruses...
- Regulation of androgen receptor activity by tyrosine phosphorylationZhiyong Guo
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Cancer Cell 10:309-19. 2006....
- A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomesAlbert Lu
Departament de Biologia Cellular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer, Serveis Cientificotecnics, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
J Cell Biol 184:863-79. 2009..Altogether, this study reveals novel aspects about KRas intracellular trafficking and signaling, shedding new light on the mechanisms controlling Ras regulation in the cell...
- Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virusQian Zhang
Genelux Corporation, San Diego Science Center, San Diego, California 92109, USA
Cancer Res 67:10038-46. 2007..These findings suggest that immune activation may combine with viral oncolysis to induce tumor eradication in this model, providing a novel perspective for the design of oncolytic viral therapies for human cancers...
- Shiga toxin subtypes display dramatic differences in potencyCynthia A Fuller
Molecular Genetics, Biochemistry, and Microbiology, Room 3109, 231 Albert Sabin Way, ML 524, University of Cincinnati, Cincinnati, OH 45267 0524, USA
Infect Immun 79:1329-37. 2011..In vivo potency in mice was also assessed. Stx2b and Stx2c had potencies similar to that of Stx1, while Stx2a, Stx2d, and elastase-cleaved Stx2d were 40 to 400 times more potent than Stx1...
- Neuroligin 2 is exclusively localized to inhibitory synapsesFrederique Varoqueaux
Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, Gottingen, Germany
Eur J Cell Biol 83:449-56. 2004..Our findings identify neuroligin 2 as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization...
- Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistinAlexandros Poulopoulos
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Gottingen, Germany
Neuron 63:628-42. 2009..Deletion of neuroligin 2 in mice perturbs GABAergic and glycinergic synaptic transmission and leads to a loss of postsynaptic specializations specifically at perisomatic inhibitory synapses...
- Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptorJens H Kuhn
Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
J Biol Chem 281:15951-8. 2006..These studies identify the receptor-binding domains of both viruses, indicate that these viruses utilize a common receptor, and suggest that a single small molecule or vaccine can be developed to inhibit infection of all filoviruses...
- Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomesMohammad F Saeed
Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
PLoS Pathog 6:e1001110. 2010..The findings greatly expand our understanding of the ZEBOV entry mechanism that can be applied to development of new therapeutics as well as provide potential insight into the trafficking and entry mechanism of other filoviruses...
- TREK-1, a K+ channel involved in neuroprotection and general anesthesiaC Heurteaux
Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
EMBO J 23:2684-95. 2004..Trek1-/- mice are also resistant to anesthesia by volatile anesthetics. TREK-1 emerges as a potential innovative target for developing new therapeutic agents for neurology and anesthesiology...
- Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expressionJeffrey Vieira
Department of Laboratory Medicine, University of Washington, Seattle, WA 98109 8070, USA
Virology 325:225-40. 2004..This work also demonstrated strong synergy between KSHV/RTA and butyrate for the activation of KSHV lytic replication and the production of infectious virus...
- Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170Masaki Fukata
Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
Cell 109:873-85. 2002..These results indicate that Rac1/Cdc42 marks special cortical spots where the IQGAP1 and CLIP-170 complex is targeted, leading to a polarized microtubule array and cell polarization...
- Cellular factors required for Lassa virus buddingShuzo Urata
First Department of Forensic Science, National Research Institute of Police Science, Kashiwa 277 0882, Japan
J Virol 80:4191-5. 2006..Our data may provide a clue to develop an effective antiviral strategy for Lassa virus...
- Quantitation of flaviviruses by fluorescent focus assayAnne F Payne
The Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, 5668 State Farm Rd, Slingerlands, NY 12159, USA
J Virol Methods 134:183-9. 2006..In addition, these viruses can be quantitated by FFA on a mosquito cell line (C6/36), which does not support plaque formation. The FFA for flaviviruses was validated for accuracy, precision, specificity, and robustness of the assay...
- High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell cultureChia Chyi Liu
Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
Vaccine 25:19-24. 2007..Therefore, serum-free microcarrier culture is a valuable process for developing inactivated EV71 vaccines...
- Targeting and activation of Rac1 are mediated by the exchange factor beta-PixJean Paul ten Klooster
Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, Netherlands
J Cell Biol 172:759-69. 2006..These data provide a model for the intracellular targeting and localized activation of Rac1 through its exchange factor beta-Pix...
- Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopmentHelen L Zenner
Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
J Virol 85:8012-21. 2011....
- The Ebola virus ribonucleoprotein complex: a novel VP30-L interaction identifiedA Groseth
National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg R3E 3R2, Canada
Virus Res 140:8-14. 2009..The identification of these interactions allows a preliminary model of the EBOV RNP complex structure to be proposed, and may provide insight into filovirus transcriptional regulation...
- Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entryAyato Takada
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
J Virol 78:2943-7. 2004..We propose that filoviruses use different C-type lectins to gain cellular entry, depending on the cell type, and promote efficient viral replication...
- Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA virusesFriedemann Weber
Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
J Virol 80:5059-64. 2006..Surprisingly, however, no dsRNA signals were detected for negative-strand RNA viruses. Thus, dsRNA is indeed a general feature of most virus groups, but negative-strand RNA viruses appear to be an exception to that rule...
- Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell linesR J Wool-Lewis
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6076, USA
J Virol 72:3155-60. 1998....
- Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphateRoberto Zoncu
Department of Cell Biology and Howard Hughes Medical Institute, Kavli Institute For Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 104:3793-8. 2007..These findings demonstrate the critical importance of PI(4,5)P(2) in clathrin coat dynamics and Arp2/3-dependent actin regulation...
- Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashionM Flamand
Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15, 91198 Gif sur Yvette Cedex, France
J Virol 73:6104-10. 1999..These results, together with observations related to the absence of secretion of NS1 from Den-infected insect cells, suggest that maturation and secretion of hexameric NS1 depend on the glycosylation status of the host cell...
- Epigallocatechin gallate inactivates clinical isolates of herpes simplex virusCharles E Isaacs
Department of Developmental Biochemistry, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
Antimicrob Agents Chemother 52:962-70. 2008..EGCG is stable in the pH range found in the vagina and appears to be a promising candidate for use in a microbicide to reduce HSV transmission...
- Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsidP Desai
Virology Laboratories, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 72:7563-8. 1998....
- Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activationTsung Hsien Chang
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
Microbes Infect 8:157-71. 2006..Therefore, we suggest that JEV and DEN-2 initiate the host innate immune response through a molecular mechanism involving RIG-I/IRF-3 and PI3K/NF-kappaB signaling pathways...
- Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1Jun Arii
Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
Nature 467:859-62. 2010..The identification of NMHC-IIA as an HSV-1 entry receptor and the involvement of NM-IIA regulation in HSV-1 infection provide an insight into HSV-1 entry and identify new targets for antiviral drug development...
- Imaging of lipid biosynthesis: how a neutral lipid enters lipid dropletsLars Kuerschner
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
Traffic 9:338-52. 2008..In vitro assays on purified lipid droplets show that this fraction of the biosynthetic TG is directly inserted into the growing droplet...
- Tyro3 family-mediated cell entry of Ebola and Marburg virusesMasayuki Shimojima
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Virol 80:10109-16. 2006..Antibody to Axl inhibited infection of pseudotype viruses in a number of Axl-positive cell lines. These results implicate each Tyro3 family member as a cell entry factor in filovirus infection...
- Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expressionRochelle M Hines
Department of Psychiatry, Brain Research Centre, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
J Neurosci 28:6055-67. 2008..These findings may provide the neural basis for E/I imbalance and altered behavior associated with neurodevelopmental disorders...
- Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicingChi Zhang
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 278:35325-36. 2003....
- High CD46 receptor density determines preferential killing of tumor cells by oncolytic measles virusBambi D Anderson
Molecular Medicine Program, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Cancer Res 64:4919-26. 2004..Discrimination between high and low CD46 receptor density provides a compelling basis for the oncolytic specificity of MV-Edm and establishes MV-Edm as a promising CD46-targeted cancer therapeutic agent...
- Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranesM G Ford
Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
Science 291:1051-5. 2001..This was shown by using purified components and a budding assay on preformed lipid monolayers. In the presence of AP180, clathrin lattices formed on the monolayer. When AP2 was also present, coated pits were formed...
- A class of membrane proteins shaping the tubular endoplasmic reticulumGia K Voeltz
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Cell 124:573-86. 2006..The simultaneous absence of the reticulons and Yop1p in S. cerevisiae results in disrupted tubular ER. We propose that these "morphogenic" proteins partition into and stabilize highly curved ER membrane tubules...
- Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancerMotohide Uemura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai 4 6 1 Minato ku, Tokyo 108 8639, Japan
Cancer Sci 99:81-6. 2008....
- A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex developmentAtsushi Kamiya
Department of Psychiatry Neurobiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 117, Baltimore, MD 21287, USA
Nat Cell Biol 7:1167-78. 2005..These results indicate that DISC1 is involved in cerebral cortex development, and suggest that loss of DISC1 function may underlie neurodevelopmental dysfunction in schizophrenia...
- Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivoM N Teng
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, 7 Center Dr. MSC 0720, Bethesda, Maryland 20892-0720, USA
Virology 289:283-96. 2001..Thus, the putative heparin-binding domain is not the sole determinant of heparin sensitivity and is not a critical functional domain...
- The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1PO Lenz
Institute of Virology, Philipps University, Robert Koch Strasse 17, 35037 Marburg, Germany
Proc Natl Acad Sci U S A 98:12701-5. 2001..To our knowledge, there have been no previous reports of this type of viral glycoprotein processing, one that may be an interesting target for antiviral therapy...
- Heterocellular induction of interferon by negative-sense RNA virusesS Chen
School of Biology, Centre for Biomolecular Sciences, BMS Building, North Haugh, University of St Andrews, St Andrews, Fife, KY16 9ST, UK
Virology 407:247-55. 2010..We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells...
- Generation of murine monoclonal antibodies which cross-neutralize human enterovirus genogroup B isolatesHsuen Wen Chang
Vaccine Research and Development Center, National Health Research Institutes, Zhunan Township, Miaoli County 350, Taiwan
J Virol Methods 173:189-95. 2011..It was also observed the monoclonal antibodies acted cooperatively in neutralizing the EV71/E59 virus...
- Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER networkSeong H Park
Cellular Neurology Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke NINDS, NIH, Bethesda, Maryland 20892 3738, USA
J Clin Invest 120:1097-110. 2010..Thus, defects in tubular ER shaping and network interactions with the microtubule cytoskeleton seem to be the predominant pathogenic mechanism of HSP...
- Assembly and maturation of the flavivirus Kunjin virus appear to occur in the rough endoplasmic reticulum and along the secretory pathway, respectivelyJ M MacKenzie
Clinical Medical Virology Centre, University of Queensland, St Lucia, Queensland 4072, Australia
J Virol 75:10787-99. 2001..The results suggest that the assembly of virions occurs within the lumen of the RER and that subsequent maturation occurs via the secretory pathway...
- Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topologySabine Kupzig
Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
Traffic 4:694-709. 2003..Data from several experiments are consistent with this localization. We present a model in which BST-2/HM1.24 serves to link adjacent lipid rafts within the plasma membrane...
- Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirusBoyd Yount
Department of Epidemiology and Microbiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Proc Natl Acad Sci U S A 100:12995-3000. 2003....
- Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosisHan Jou Chen
Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom
J Biol Chem 285:40266-81. 2010..In summary, we show that this newly identified mutation in human FALS has a pathogenic effect, supporting and reinforcing the role of VAPB as a causative gene of ALS...
- Vesicular stomatitis virus-based Ebola vaccines with improved cross-protective efficacyAndrea Marzi
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, Montana 59840, USA
J Infect Dis 204:S1066-74. 2011..Our data demonstrate that cross-protection between the EBOV species can be achieved, although EBOV-GP alone cannot induce the required immune response...
- The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequenceJ V Frangioni
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
Cell 68:545-60. 1992..The C-terminal 35 amino acids of PTP-1B are both necessary and sufficient for targeting to the ER. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation...
- Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubulesTakashi Watanabe
Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan
J Cell Sci 122:2969-79. 2009..Thus, phosphorylation of CLASP2 by GSK-3beta appears to control the regional linkage of microtubules to actin filaments through IQGAP1 for cell migration...
- Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variantsMatthew W McNatt
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America
PLoS Pathog 5:e1000300. 2009....
- Continuous cell lines as a production system for influenza vaccinesYvonne Genzel
Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering Magdeburg, Sandtorstr 1, Magdeburg 39106, Germany
Expert Rev Vaccines 8:1681-92. 2009..These encouraging developments for cell culture-based influenza virus production are summarized and an overview on potential cell substrates is given...
- Cellular and viral requirements for rapid endocytic entry of herpes simplex virusAnthony V Nicola
Medical Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1888, USA
J Virol 78:7508-17. 2004..Thus, similar to entry via direct penetration at the cell surface, HSV entry into cells by wortmannin-sensitive endocytosis is efficient, involves rapid cellular uptake of viral particles, and requires gB, gD, and gH-gL...
- Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin proteinMark L Reed
Department of Infectious Diseases, MS 330, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
J Virol 83:3568-80. 2009..Overall, the data show that residues comprising the fusion peptide pocket are important in triggering pH-dependent activation of the H5 HA protein...
- The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signalingMaudry Laurent-Rolle
Laboratory of Virology, Rocky Mountain Laboratories, 903 S Fourth St, Hamilton, MT 59840, USA
J Virol 84:3503-15. 2010..Thus, a naturally occurring mutation is associated with the function of NS5 in IFN antagonism and may influence virulence of WNV field isolates...
- Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinaseYi I Wu
Department of Cell and Molecular Biology and Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
J Biol Chem 279:8278-89. 2004..These data provide evidence for an additional mechanism for post-translational control of MT1-MMP activity and suggest that glycosylation of MT1-MMP may regulate its substrate targeting...
- Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathyAnne Sophie Nicot
Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Department of Molecular Pathology, F 67400 Illkirch, France
Nat Genet 39:1134-9. 2007....
- Peripheral ER structure and functionAmber R English
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Curr Opin Cell Biol 21:596-602. 2009....
- RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathwayHiroaki Kajiho
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
J Cell Sci 116:4159-68. 2003..These results indicate that RIN3 biochemically characterized as the stimulator and stabilizer for GTP-Rab5 plays an important role in the transport pathway from plasma membrane to early endosomes...
- The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1D Perkins
Departments of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201, USA
J Virol 77:1292-305. 2003..Collectively, the data indicate that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation and overrides the proapoptotic JNK/c-Jun signal induced by other viral proteins...
- Respiratory syncytial virus nonstructural proteins decrease levels of multiple members of the cellular interferon pathwaysSamer Swedan
Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, 307 University Blvd, Mobile, AL 36688 0002, USA
J Virol 83:9682-93. 2009..Coimmunoprecipitation studies revealed that NS1 and NS2 form a heterodimer. Clearly, the NS proteins of RSV, working individually and together, regulate key signaling molecules of both the IFN activation and response pathways...
- Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5Yasuhiko Nakamura
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Biochem Biophys Res Commun 366:174-9. 2008..These results suggest that the SIRT3, SIRT4, and SIRT5 proteins exert distinct functions in mitochondria. In addition, the SIRT3 protein might function in nucleus...
- Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinasesM B Calalb
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
Mol Cell Biol 15:954-63. 1995..Our results indicate that phosphorylation of FAK by Src (or other Src family kinases) is an important step in the formation of an active signaling complex...
- Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motifRuth Rollason
Department of Biochemistry, University of Bristol, Bristol, BS8 1T, UK
J Cell Sci 120:3850-8. 2007....
- Assembly and budding of EbolavirusTakeshi Noda
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
PLoS Pathog 2:e99. 2006..These data form a foundation for the identification and development of potential antiviral agents to combat the devastating disease caused by this virus...
- Glycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1Richard S B Milne
Department of Microbiology, University of Pennsylvania, School of Dental Medicine, 215 Levy Building, 240 South 40th Street, Philadelphia, PA 19104 6002, USA
J Virol 79:6655-63. 2005..Resistance to similar reagents should therefore not be taken as proof of HSV entry by a nonendosomal pathway. These data define a novel gD receptor-dependent acid-independent endocytic entry pathway for HSV...
- Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cellsShumei Ren
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15 Nishi 7, Kita ku, Sapporo 060 0815, Japan
J Biol Chem 281:32344-52. 2006..The present work raises the possibility that inhibition of CagA multimerization abolishes pathophysiological activities of CagA that promote gastric carcinogenesis...
- Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strainMarc G Wathelet
Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
J Virol 81:11620-33. 2007..However, mutant virus replication was strongly attenuated in cells with an intact IFN response. Thus, nsp1 is likely a virulence factor that contributes to pathogenicity by favoring SARS-CoV replication...
- Temporal analysis of Coxiella burnetii morphological differentiationSherry A Coleman
Coxiella Pathogenesis Unit, NIAID NIH, Rocky Mountain Laboratories, 903 S 4th Street, Hamilton, MT 59840, USA
J Bacteriol 186:7344-52. 2004..The experimental model described in this report will allow a global transcriptome and proteome analysis of C. burnetii developmental forms...
- DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication fociM R Rountree
The Johns Hopkins Oncology Center, Tumor Biology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Genet 25:269-77. 2000..Thus, DNMT1 not only maintains DNA methylation, but also may directly target, in a heritable manner, transcriptionally repressive chromatin to the genome during DNA replication...
- Phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0Roger D Everett
MRC Virology Unit, Institute of Virology, Glasgow G11 5JR, Scotland, United Kingdom
J Virol 78:1763-74. 2004....
- Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domainSinisa Urban
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Mol Cell 11:1425-34. 2003..These results provide an explanation of how rhomboid proteases achieve specificity, and allow some rhomboid substrates to be predicted from sequence information...
- Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleusB Sodeik
Yale University School of Medicine, Department of Cell Biology, New Haven, Connecticut 06520 8002, USA
J Cell Biol 136:1007-21. 1997..We propose that the incoming capsids bind to microtubules and use dynein to propel them from the cell periphery to the nucleus...
- Differential inhibition of type I interferon induction by arenavirus nucleoproteinsLuis Martinez-Sobrido
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Virol 81:12696-703. 2007..Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production...
- N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2Karen M Page
Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
J Biol Chem 285:835-44. 2010..Taken together, our evidence indicates that both the extreme N terminus and the Arg(52), Arg(54) motif are involved in the processes underlying dominant negative suppression...
- AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infectionLaure Campillo-Gimenez
Institut National de la Santé et de la Recherche Médicale U 955, Faculté de Médecine de Créteil, Hopital Henri Mondor, Creteil, France
J Immunol 184:984-92. 2010..Altogether, these results demonstrate that IL-17-producing NKT are associated with the pathogenesis of SIV in RMs and suggest that TGF-beta and IL-18 play a role in their development...
- Real-time computation of subdiffraction-resolution fluorescence imagesS Wolter
Applied Laser Physics and Laser Spectroscopy, Department of Physics, Bielefeld University, Universitatsstrasse 25, D 33615 Bielefeld, Germany
J Microsc 237:12-22. 2010....
- During lytic infections, herpes simplex virus type 1 DNA is in complexes with the properties of unstable nucleosomesJonathan J Lacasse
Signal Transduction Research Group, Molecular Mechanisms of Growth Control Research Group, University of Alberta, 327C Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
J Virol 84:1920-33. 2010..The HSV-1 DNAs in complexes fractionating as mono- to dinucleosomes were stabilized by cross-linking. Therefore, most HSV-1 DNA forms particularly unstable nucleosome-like complexes at 5 h of lytic infection...
- Self-limiting, and Dominant-negative Herpes Simplex Virus RecombinantsFeng Yao; Fiscal Year: 2007..Specific Aim 4 will focus on investigating the influence of de novo expression of B7-1 and B7-2 by HSV-1 replication-defective vaccine virus on the augmentation of host immunity against HSV infection. [unreadable] [unreadable]..
- Brain and Behavioral Alterations After MethamphetamineWilliam Melega; Fiscal Year: 2004..METH dose protocol that reflects human METH abuse patterns will be administered to vervet monkeys (Cercopithecus aethiops sabaeus) housed in naturally composed social groups...
- NEUROAMINE RECEPTOR REG DURING INDUCTION & WITHDRAWALDeborah Mash; Fiscal Year: 1993..We propose to conduct these studies in animals taken from an experimental colony of Vervet monkeys (Cercopithecus aethiops) that have been previously characterized for their descriptive behaviors and alcohol preference...
- QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life ChangLynn Fairbanks; Fiscal Year: 2009..This is a novel way of assessing the role of the gene-environment interactions in measuring effects of genetic variation on behavior traits ..
- Behavioral Genetics of ImpulsivityLynn Fairbanks; Fiscal Year: 2005..Subjects for this research are 725 vervet monkeys (Cercopithecus aethiops sabaeus), living in naturally composed social groups in a multigenerational, pedigreed colony that ..
- Selective Prenatal Dopamine Damage in Non Human PrimatesJohn Elsworth; Fiscal Year: 2003..Thus, the proposed work may lead ultimately to an animal model for one or more pediatric brain disorders. ..
- Estrogenic Effect on Hippocampal Theta Rhythm and MemoryCsaba Leranth; Fiscal Year: 2004....
- Negative Effects of Bisphenol A on the Monkey CNSCsaba Leranth; Fiscal Year: 2008..Therefore, we propose to reveal the effect of BPA on estrogen-induced spine synapse formation in the brain of non-human primates, which will provide more relevance to human health. [unreadable] [unreadable] [unreadable]..
- Subcortical Estrogen Effect on The HippocampusCsaba Leranth; Fiscal Year: 2005..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
- Early experience and low 5-HT markers in alcohol abuseMark Laudenslager; Fiscal Year: 2009..Finally, involvement of the HPA axis in these relationships will be investigated as an exploratory goal. ..
- BEHAVIORAL AND PHYSIOLOGICAL CONSEQUENCES OF LOSSMark Laudenslager; Fiscal Year: 2003..The present application seeks to identify developmental factors affecting the HPA axis and the balance of CORT and DHEA with consequences for individual differences in rates of progression in immunodeficiency disease. ..
- Animal models to design & evaluate improved VZV vaccinesWAYNE GRAY; Fiscal Year: 2007..The study may also provide support for use of the VZV vaccine as a recombinant vector for immunization against other infectious agents, particularly human immunodeficiency virus (HIV). ..
- Mosquito Immunity to AlphavirusesBrian Foy; Fiscal Year: 2006..3) Characterize the mechanisms that Culex tritaeniorhynchus mosquitoes use to clear Sindbis virus-infected midgut cells. [unreadable] [unreadable]..
- Bioreactor for Engineered Bioartificial Tissues (BATS)Albert Banes; Fiscal Year: 2005..Expansion to a larger bioreactor chamber will allow biomedical researchers to develop better strategies for growth and testing of scaled up tissues for use in vivo in numerous connective tissue applications. ..
- MOLECULAR MECHANISM OF RENAL NA+ DEPENDENT COTRANSPORTAna M Pajor; Fiscal Year: 2010..Understanding how NaDC1 and SdcS work will help us to develop treatments for NaDC1-mediated diseases. ..
- CEREBROVASCULAR ION CHANNELS IN HYPERTENSIONJ Marc Simard; Fiscal Year: 2007..abstract_text> ..
- Improving neural graft function in parkinsonian monkeys.DONALD REDMOND; Fiscal Year: 2007..abstract_text> ..
- Genotypic and Phenotypic Analysis of West Nile virus, Yucatan Peninsula of MexicoBradley Blitvich; Fiscal Year: 2008..This information will help determine why there has not been an epidemic of WNV in the YP, and will identify risk factors associated with WNV disease. [unreadable] [unreadable] [unreadable]..
- GDNF Delivery to MPTP Monkeys by EIAV lentivirus and AAVDONALD REDMOND; Fiscal Year: 2008..These studies aim to provide the necessary data to initiate successful clinical trials in Parkinson's patients at the earliest possible time. ..
- Pitx2 Function in Developing Mouse Brain NeuronsDonna M Martin; Fiscal Year: 2010..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
- Role of Retroelements in Environmental AtherogenesisKenneth S Ramos; Fiscal Year: 2010..Studies are proposed in this application to study the role of virus-like sequences in the onset and progression of environmentally-induced atherosclerosis in experimental systems. ..
- BETA 1 AND BETA 3 ADRENORECEPTORSJAMES GRANNEMAN; Fiscal Year: 2001..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
- PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELSJ Simard; Fiscal Year: 2004....
- MOLECULAR MECHANISMS OF CHEMICAL ATHEROGENESISKenneth Ramos; Fiscal Year: 2005..These studies will enable us to define the role of ARE/EpRE binding proteins in oxidant-induced atherogenesis and identify critical transacting factors involved in the atherogenic response to environmental injury. ..
- 2004 Mechanisms of Toxicity Gordon Research ConferenceKenneth Ramos; Fiscal Year: 2004..Thus, the 2004 conference is poised to continue its growth as the single leading small conference in toxicology. ..
- PHARYNGEAL MYOGENESIS AND ORGANOGENESIS IN C ELEGANSPETER OKKEMA; Fiscal Year: 2004..Finally we are specifically examining role the PEB-l plays during pharyngeal development by isolating and characterizing apeb-1 mutant. ..
- FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENESYun Fai Chris Lau; Fiscal Year: 2004..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..
- Mechanisms of Centrosome Reproduction in Animal CellsEDWARD HINCHCLIFFE; Fiscal Year: 2009..abstract_text> ..
- UL34 and herpes simplex virus envelopmentRichard J Roller; Fiscal Year: 2010..3. We will fully characterize changes in the host cell nuclear lamina associated with infection and determine the mechanism by which UL34 and other viral proteins accomplish those changes. ..
- Pathogenesis of SIV in African green monkeysIvona Pandrea; Fiscal Year: 2010..Combined, these aims are designed to determine the viral and/or host factors responsible for resistance to AIDS. ..
- OSTEOPONTIN AND OXIDATIVE STRESS IN ATHEROGENESISKenneth Ramos; Fiscal Year: 2003..These studies are important in view of the increasing scrutiny of the role of oxidative injury in the onset and progression of atherogenesis. ..
- Function and regulation of T-box factors in C. elegansPeter G Okkema; Fiscal Year: 2010..elegans, and the results obtained will have a direct bearing on our understanding of these factors in all organisms. ..
- Peroxiredoxin 6 and CataractogenesisDhirendra P Singh; Fiscal Year: 2010..The proposed studies will provide a sound scientific basis for developing an antioxidant-based therapy or combination of therapies for preventing cataractogenesis and age-associated degenerative diseases in general. ..
- Transformation of Cells by the REL OncogeneThomas Gilmore; Fiscal Year: 2009....
- Role of Leucine Metabolism in Leucine SignalingCHRISTOPHER JOHN LYNCH; Fiscal Year: 2010..The implication of our ongoing research is that blocking the first step in BCAA metabolism with a drug, or to a less extent increasing dietary BCAAs, will promote weight loss. ..
- A High-Throughput Screen to Identify Small Molecule Compounds That AugmentBrent Passer; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- HUMAN NEURAL STEM CELLS IN PRIMATE PARKINSON'S MODELDONALD REDMOND; Fiscal Year: 2004..The results will also advance understanding of useful methods for studying and treating a broad range of neurodegenerative, genetic, and traumatic conditions of the nervous system. ..
- Genetic analysis of congenital diaphragmatic herniaAnne Slavotinek; Fiscal Year: 2006..abstract_text> ..
- Analysis of Therapeutic Adipose Tissue RemodelingJAMES GRANNEMAN; Fiscal Year: 2004..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma. ..
- Arbovirus quasispecies-impact of arthropod transmissionGREGORY EBEL; Fiscal Year: 2004..abstract_text> ..
- Role of Pitx2 in the Mammalian Central Nervous SystemDonna Martin; Fiscal Year: 2005..5-14.5) mouse diencephalon, 2) Develop and analyze mice with Pitx2 loss of function, and 3) Develop and analyze transgenic mice with CNS-specific Pitx2 gain of function. ..
- Reactive astrocytes from gliotic capsuleJ Marc Simard; Fiscal Year: 2007..unreadable] [unreadable]..
- TENDON CELLS:INTERACTIONS & RESPONSES TO STRESS IN VITROAlbert Banes; Fiscal Year: 2004..Knowledge of how motion acts at the mechanistic level may lead to drug strategies for upregulating cell division and matrix expression with or without motion in aged or disabled patients. ..
- REGULATION OF ADIPOCYTE PROTEIN SYNTHESIS BY AMINO ACIDSChristopher Lynch; Fiscal Year: 2007..The proposed studies will elucidate how leucine regulates mTOR and the roles of leucine stimulation of mTOR in adipose tissue physiology and obesity. ..
- Membrane Organization in Cell Signaling and AdhesionTione Buranda; Fiscal Year: 2008..Completion of the proposed work will yield a better mechanistic grasp of the dynamics of membrane organization as a factor in signaling and cell adhesion. ..
- Development of an VEE Replicon Vaccine Against SmallpoxKurt Kamrud; Fiscal Year: 2005....
- Viral Genes Essential for MHV-68 Persistent Infection in the SpleenRen Sun; Fiscal Year: 2008..These viruses will strongly stimulate immune responses but will not establish persistent infection to cause diseases, thus a potential vaccine strategy. [unreadable] [unreadable] [unreadable]..
- CTL-BASED VACCINES FOR THE AIDS VIRUSDavid Watkins; Fiscal Year: 2003..John Altman will synthesize MHC class I tetramers for CTL quantitation and Deborah Fuller will immunize animals using the gene gun. ..
- MECHANISM OF INTERFERON ACTIONCHARLES SAMUEL; Fiscal Year: 2009..Furthermore, elucidation of the actions of IFN at the molecular level is of importance in view of potential applications of interferon in the clinic. ..
- CENTER FOR CANCER SIGNALING NETWORKSWalter Atwood; Fiscal Year: 2009..This award will fund the retention of a young assistant professor, enable the hiring of a research assistant and provide a reasonable budget for supplies. ..
- IgA-Antigen Uptake by Peyer's Patch M cellsNICHOLAS MANTIS; Fiscal Year: 2003..The three year KO1 award will provide the applicant with-additional research training and career skills that will greatly facilitate his transition to becoming a successful independent research investigator. ..