zucker rats

Summary

Summary: Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.

Top Publications

  1. ncbi Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
    Leonor Rivera
    Department of Pharmacology, CIBER EHD, CTS 164 Research Group, School of Pharmacy, University of Granada, Campus Universitario Cartuja s n, 18071 Granada, Spain
    Biochem Pharmacol 77:1053-63. 2009
  2. ncbi Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
    Leonor Rivera
    Department of Pharmacology, CIBER EHD, School of Pharmacy, University of Granada, Granada, Spain
    Obesity (Silver Spring) 16:2081-7. 2008
  3. ncbi Leptin receptor missense mutation in the fatty Zucker rat
    M S Phillips
    Nat Genet 13:18-9. 1996
  4. ncbi Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats
    D Kramer
    Diabetes Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA
    Metabolism 50:1294-300. 2001
  5. ncbi ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Obesity (Silver Spring) 16:770-6. 2008
  6. ncbi Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats
    Barbara Batetta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Cagliari, Cagliari 09100, Italy
    J Nutr 139:1495-501. 2009
  7. ncbi Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    A A Young
    Amylin Pharmaceuticals, San Diego, California 92121, USA
    Diabetes 48:1026-34. 1999
  8. ncbi Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats
    J B C Carvalheira
    Departamento de Clinica Medica, FCM, Universidade Estadual de Campinas UNICAMP, 13081 970, Campinas, SP, Brasil
    Diabetologia 46:1629-40. 2003
  9. ncbi Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    F C Lynn
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Diabetes 50:1004-11. 2001
  10. ncbi Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats
    A Enriquez
    Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biochem Biophys Res Commun 255:300-6. 1999

Detail Information

Publications255 found, 100 shown here

  1. ncbi Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
    Leonor Rivera
    Department of Pharmacology, CIBER EHD, CTS 164 Research Group, School of Pharmacy, University of Granada, Campus Universitario Cartuja s n, 18071 Granada, Spain
    Biochem Pharmacol 77:1053-63. 2009
    ..resveratrol on several functional alterations arising from the metabolic syndrome experimental model of obese Zucker rats, and the possible mechanisms involved...
  2. ncbi Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
    Leonor Rivera
    Department of Pharmacology, CIBER EHD, School of Pharmacy, University of Granada, Granada, Spain
    Obesity (Silver Spring) 16:2081-7. 2008
    ..For this purpose, obese Zucker rats and their lean littermates were used...
  3. ncbi Leptin receptor missense mutation in the fatty Zucker rat
    M S Phillips
    Nat Genet 13:18-9. 1996
  4. ncbi Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats
    D Kramer
    Diabetes Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA
    Metabolism 50:1294-300. 2001
    ....
  5. ncbi ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Obesity (Silver Spring) 16:770-6. 2008
    ....
  6. ncbi Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats
    Barbara Batetta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Cagliari, Cagliari 09100, Italy
    J Nutr 139:1495-501. 2009
    ..and DHA and similar contents of oleic, linoleic, and alpha-linolenic acids, on ectopic fat and inflammation in Zucker rats, a model of obesity and related metabolic dysfunction. Diets were fed for 4 wk...
  7. ncbi Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    A A Young
    Amylin Pharmaceuticals, San Diego, California 92121, USA
    Diabetes 48:1026-34. 1999
    ..25 microg/kg +/-0.09 log. In two experiments in which diabetic fatty Zucker rats were injected subcutaneously twice daily for 5-6 weeks with doses of exendin-4 up to 100 microg x rat(-1) x day(..
  8. ncbi Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats
    J B C Carvalheira
    Departamento de Clinica Medica, FCM, Universidade Estadual de Campinas UNICAMP, 13081 970, Campinas, SP, Brasil
    Diabetologia 46:1629-40. 2003
    ..By acting in the brain, insulin suppresses food intake. However, little is known with regard to insulin signalling in the hypothalamus in insulin-resistant states...
  9. ncbi Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    F C Lynn
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Diabetes 50:1004-11. 2001
    ..This hypothesis was tested using a strain of diabetic fatty Zucker rats. The obese rats displayed basal GIP levels similar to the control animals; however, they were unresponsive to a ..
  10. ncbi Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats
    A Enriquez
    Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biochem Biophys Res Commun 255:300-6. 1999
    ..we analyzed the hepatic expression of CYP2E1 and CYP4A in ob/ob mice which are leptin deficient, and fa/fa Zucker rats which have defective leptin receptor function...
  11. ncbi Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats
    Peter Boor
    Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, 833 03 Bratislava, Slovakia
    Metabolism 58:1669-77. 2009
    ..Here we examined whether a regular moderate exercise in obese Zucker rats (OZR), a model of diabetes- and obesity-associated nephropathy, will affect the development of early renal ..
  12. ncbi Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats
    Nicholas D Oakes
    AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Am J Physiol Regul Integr Comp Physiol 289:R938-46. 2005
    ..7/2.0 g/kg lean body mass) load in three groups of conscious 7-h fasted Zucker rats: lean healthy controls, obese insulin-resistant/dyslipidemic controls, and obese rats treated with the dual ..
  13. ncbi Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    Dong Hyun Kim
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 325:833-40. 2008
    ..These findings highlight the pivotal role and symbiotic relationship of HO-1 and adiponectin in the modulation of the metabolic syndrome phenotype...
  14. ncbi AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats
    Bengt Ljung
    AstraZeneca R and D, Research Area CV GI, Mölndal S 431 83 Mölndal, Sweden
    J Lipid Res 43:1855-63. 2002
    ..clamp studies showed that treatment with AZ 242 (1 micromol/kg/d) restored insulin sensitivity of obese Zucker rats and decreased insulin secretion...
  15. ncbi Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes
    B L Leonard
    School of Biological Sciences, University of Auckland, New Zealand
    Acta Diabetol 42:162-70. 2005
    ..Collectively, these results provide an integrated characterisation of in vivo insulin resistance in obese ZDF rats and a direct comparison with lean littermates...
  16. ncbi Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats
    J C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H1304-11. 2001
    ..alterations to nitric oxide (NO)-dependent dilation of skeletal muscle arterioles from obese (OZR) versus lean Zucker rats (LZR)...
  17. pmc Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
    Charissa E van den Brom
    Department of Internal Medicine Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Cardiovasc Diabetol 9:25. 2010
    ..The purpose of the present study was to investigate whether LV changes are paralleled by RV alterations in a rat model of diabetes...
  18. ncbi Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats
    E Teixeira de Lemos
    Therapeutics Unit, Institute of Pharmacology and Experimental Therapeutics, Medicine Faculty, Coimbra University, Coimbra, Portugal Polytechnic Institute of Viseu, Viseu, Portugal
    Nutrition 25:330-9. 2009
    ....
  19. ncbi Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats
    E J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ, USA
    Hypertension 38:884-90. 2001
    ....
  20. ncbi Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats
    Sachi Hoshi
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Lab Invest 82:25-35. 2002
    ..High concentrations of ambient glucose induced podocyte hypertrophy and stress in vitro, suggesting that the podocyte is a likely target of the diabetic milieu...
  21. ncbi Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    M Yuan
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Science 293:1673-7. 2001
    ..These findings implicate an inflammatory process in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus and identify the IKKbeta pathway as a target for insulin sensitization...
  22. ncbi Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats
    J P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Atherosclerosis 148:231-41. 2000
    ..We conclude that the obese ZDF female rat has the potential to become an important animal model of NIDDM especially in women where few models currently exist...
  23. ncbi Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity
    Daniel Bach
    Parc Cientific de Barcelona, Facultat de Biologia, Universitat de Barcelona, Barcelona 08028, Spain
    J Biol Chem 278:17190-7. 2003
    ....
  24. ncbi Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition
    X Yu
    Gifford Laboratories of the Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diabetologia 47:2012-21. 2004
    ....
  25. ncbi Exaggerated cardiovascular stress responses and impaired beta-adrenergic-mediated pressor recovery in obese Zucker rats
    Gerard D'Angelo
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta 30912 2500, USA
    Hypertension 48:1109-15. 2006
    ..tested the hypotheses that the pressor response to behavioral stress is greater in obese (OZRs) versus lean Zucker rats (LZRs) and that reduced beta-adrenergic-mediated vasodilation contributes to the enhanced pressor response...
  26. ncbi Effects of calcium and plant sterols on serum lipids in obese Zucker rats on a low-fat diet
    Timo Vaskonen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    Br J Nutr 87:239-45. 2002
    ..the effects of different dietary Ca levels on the serum lipid profile and cholesterol metabolism in obese Zucker rats fed a low-fat diet...
  27. ncbi In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 296:E738-47. 2009
    ..Therefore, in red and white muscles of lean and obese Zucker rats, we examined whether the increase in IMTG accumulation was attributable to an increased rate of fatty acid ..
  28. ncbi Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo
    Bella Kalderon
    Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120
    Am J Physiol Endocrinol Metab 284:E795-803. 2003
    ..sensitizers in modulating adipose tissue lipolysis in the fasting state was evaluated in obese conscious Zucker rats treated with troglitazone or beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) and compared with ..
  29. ncbi Adenosinergic modulation of ventilation in obese zucker rats
    Shin Da Lee
    Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Obes Res 13:545-55. 2005
    The goal of our study was to determine whether altered adenosinergic mechanisms contribute to the depressed ventilatory response observed in obese Zucker rats.
  30. ncbi Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of obese Zucker rats
    L P Turcotte
    Department of Kinesiology and University of Southern California Diabetes Center, University of Southern California, 3560 Watt Way, PED 107, Los Angeles, CA 90089, USA
    Diabetes 50:1389-96. 2001
    ..plasma membrane fatty acid-binding protein (FABP(PM)) content of lean (n = 16, fa/+) and obese (n = 15, fa/fa) Zucker rats (12 weeks of age)...
  31. pmc Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension
    Adam G Goodwill
    Center for Interdisciplinary Research in Cardiovascular Science, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26505, USA
    Am J Physiol Heart Circ Physiol 295:H1522-8. 2008
    ..with reduced Po(2) contributes to impaired hypoxic dilation of skeletal muscle resistance arterioles of obese Zucker rats (OZRs) versus lean Zucker rats (LZRs)...
  32. ncbi Reduced plasma volume and mesenteric vascular reactivity in obese Zucker rats
    Ann M Schreihofer
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Regul Integr Comp Physiol 288:R253-61. 2005
    Obese Zucker rats (OZR) are mildly hypertensive with an apparently elevated sympathetic vasomotor tone compared with lean Zucker rats (LZR)...
  33. ncbi Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats
    Amer C Hakam
    Department of Pharmacological and Pharmaceutical Sciences, Science and Research Building 2, University of Houston, 4800 Calhoun, Houston, TX 77204 5037, USA
    Hypertension 45:270-5. 2005
    ..on natriuresis/diuresis and compare the level of the tubular AT(2) receptor expression in obese and lean Zucker rats (12 weeks old)...
  34. ncbi Rosiglitazone restores G-protein coupling, recruitment, and function of renal dopamine D1A receptor in obese Zucker rats
    Meghna Trivedi
    Heart and Kidney Institute, College of Pharmacy, University of Houston, Houston, Tex 77204 5041, USA
    Hypertension 43:376-82. 2004
    ..to G proteins and dopamine-induced recruitment of D1A receptors to the plasma membrane are impaired in obese Zucker rats, resulting in a diminished natriuretic and diuretic response to D1A receptor agonist, SKF-38393...
  35. ncbi Impaired sarcolemmal vesicle lactate uptake and skeletal muscle MCT1 and MCT4 expression in obese Zucker rats
    G Py
    Département de Biochimie Métabolique et Clinique, Faculte de Pharmacie, 34060 Montpellier, France
    Am J Physiol Endocrinol Metab 281:E1308-15. 2001
    ..Compared with controls, the maximal rate of lactate uptake and affinity were decreased in SV of Zucker rats (approximately 30%) in which MCT4 content was significantly decreased (P < 0.05)...
  36. ncbi Body weight, body composition, and energy metabolism in lean and obese Zucker rats fed soybean oil or butter
    Valérie Rolland
    Laboratoire de Neurobiologie des Regulations, CNRS, Paris, France
    Am J Clin Nutr 75:21-30. 2002
    ..Dietary fat composition is thought to affect body weight regulation independent of the amount of fat ingested...
  37. ncbi Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats
    R Bergeron
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Diabetes 50:1076-82. 2001
    ..The effects of these identical AICAR and insulin infusion rates were then examined in the obese Zucker rats. AICAR infusion increased muscle AMPK activity more than fivefold (P < 0.01 vs...
  38. pmc Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril
    J E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, CONICET, Av Pueyrredon 1640, Buenos Aires 1118, Argentina
    Heart 91:80-6. 2005
    ....
  39. ncbi Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
    J M Way
    Department of Molecular Endocrinology, Glaxo Wellcome Inc, Research and Development, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 142:1269-77. 2001
    ....
  40. pmc Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity
    Lisa M Davis
    Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Neuroendocrinology 89:152-62. 2009
    ....
  41. ncbi Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats
    Essam M Hamad
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Br J Nutr 101:716-24. 2009
    ..In experiment 1, lean and obese Zucker rats were fed a diet containing SM or LGSP for 4 weeks...
  42. ncbi Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats
    D Richard
    Departement de Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Endocrinology 137:4786-95. 1996
    ..of type 1 (CRF1R) and type 2 alpha (CFR2R) in the brain has been investigated in lean (Fa/?) and obese (fa/fa) Zucker rats. Exonic and intronic in situ hybridization histochemistry was employed to measure the mRNA and hnRNA levels in ..
  43. pmc K(ATP)-mediated vasodilation is impaired in obese Zucker rats
    Benjamin L Hodnett
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Microcirculation 15:485-94. 2008
    Skeletal muscle blood flow during exercise is impaired in obesity. We tested the hypothesis that the attenuated vasodilation in skeletal muscle arterioles of obese Zucker rats (OZR) is due to altered K(ATP) channel-mediated vasodilation.
  44. ncbi Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats
    J M Overton
    Departments of Nutrition, Food and Exercise Sciences and Program in Neuroscience, 236 Biomedical Research Facility, Florida State University, Tallahassee, FL 32306 4340, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1007-15. 2001
    ..Lean (Fa/?; normal leptin receptor; n = 7) and obese (fa/fa; mutated leptin receptor; n = 8) Zucker rats were instrumented with telemetry transmitters and housed in metabolic chambers at 23 degrees C (12:12-h light-..
  45. pmc Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats
    Yanbin Zheng
    Section of Endocrinology, The University of Chicago, 900 E 57th Street, KCBD Room 8122, Chicago, Illinois 60637, USA
    J Endocrinol 203:337-47. 2009
    ..Obese and lean Zucker rats were subjected to 40% CR or allowed to feed ad libitum (AL) for 20 weeks; body weight and insulin sensitivity ..
  46. ncbi Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats
    Bernard Beck
    UHP EA 3453 IFR 111 Systèmes Neuromodulateurs des Comportements Ingestifs 38, rue Lionnois 54000 Nancy, France
    Life Sci 76:473-8. 2004
    ..In the present experiment, we determined the circulating ghrelin levels in 60-week old fa/fa Zucker rats with a well-established obesity (n = 12) and in their lean (FA/FA) counterparts (n = 12)...
  47. pmc Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker rats
    Elizabeth M Muellenbach
    Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721, USA
    Life Sci 84:563-8. 2009
    ..PYR) and the antioxidant alpha-lipoic acid (LA) interact to ameliorate insulin resistance in obese Zucker rats following short-term (6-week) treatment...
  48. ncbi Activation of the central nervous system in obese Zucker rats during food deprivation
    E Timofeeva
    , , , Canada, G1K 7P4
    J Comp Neurol 441:71-89. 2001
    ..The functional activation of neurons was estimated in lean and obese Zucker rats either fed ad libitum or food-deprived for 3, 6, 12, and 24 hours by assessing the expression of the immediate ..
  49. ncbi IGF-I transcript levels in whole-liver tissue, in freshly isolated hepatocytes, and in cultured hepatocytes from lean and obese Zucker rats
    S Tenoutasse
    Research Unit on the Biology of Reproduction and Development, Research Center, Ste Justine Hospital, Montreal, Que, Canada
    Horm Res 59:135-41. 2003
    ....
  50. ncbi Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats
    J J Hwa
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    Am J Physiol Regul Integr Comp Physiol 281:R444-51. 2001
    ..the involvement of melanocortins in feeding, energy metabolism, and body weight regulation in lean and obese Zucker rats. Central administration of a melanocortin receptor antagonist (SHU9119) elevated food intake and body weight of ..
  51. ncbi Metabolic syndrome increases endogenous carbon monoxide production to promote hypertension and endothelial dysfunction in obese Zucker rats
    Fruzsina K Johnson
    Tulane Hypertension and Renal Center of Excellence, New Orleans, Louisiana, USA
    Am J Physiol Regul Integr Comp Physiol 290:R601-8. 2006
    ..Obese Zucker rats (ZR) are models of metabolic syndrome...
  52. ncbi Cardiovascular effects of captopril and enalapril in obese Zucker rats
    J Duarte
    Department of Pharmacology, School of Pharmacy, University of Granada, Spain
    Eur J Pharmacol 365:225-32. 1999
    ..uptake, arterial blood pressure, cardiac hypertrophy, proteinuria and aortic vascular reactivity in obese Zucker rats were evaluated...
  53. ncbi Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats
    Jefferson C Frisbee
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 283:H2160-8. 2002
    ..characterized myogenic activation of skeletal muscle (gracilis) resistance arteries from lean (LZR) and obese Zucker rats (OZR)...
  54. ncbi Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese Zucker rats
    Olivier Aprikian
    Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont Ferrand Theix and CRNH d Auvergne, 63122 St Genes Champanelle, France
    J Nutr 132:1969-76. 2002
    ..25 g/100 g cholesterol and provided only one third of the vitamin E requirement. Obese Zucker rats were hypercholesterolemic with cholesterol accumulation in LDL and HDL fractions...
  55. ncbi Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats
    R J Seeley
    Department of Psychology, University of Washington, Seattle 98195-1525, USA
    Horm Metab Res 28:664-8. 1996
    ..microg of either mouse or human leptin into the third ventricle (ICV) of lean Long-Evans rats or obese (fa/fa) Zucker rats, in which obesity results from a mutation in the leptin receptor gene...
  56. ncbi Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats
    Mohammad Asghar
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
    Mol Cell Biochem 304:93-9. 2007
    ..investigated the effect of HCA-SX on inflammation, oxidative stress and insulin resistance in developing obese Zucker rats, an animal model of type II diabetes associated with inflammation and oxidative stress...
  57. pmc Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa)
    Abdelali Agouni
    INSERM, U771, Angers, France
    PLoS ONE 4:e5557. 2009
    ....
  58. ncbi Serotonin delivery into the ventromedial nucleus of the hypothalamus affects differently feeding pattern and body weight in obese and lean Zucker rats
    Serguei O Fetissov
    Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Appetite 54:346-53. 2010
    ..To determine if central serotonin (5-HT)-induced satiety is altered in obesity...
  59. ncbi Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats
    Michel Beylot
    INSERM U499, Metabolic and Renal Physiolopathology, Faculté RTH Laennec, 69008 Lyon, France
    Metabolism 55:396-401. 2006
    ..05) in AdipoR2 mRNA level in the liver of rats fed with an HF diet. In obese Zucker rats compared with their lean controls, neither AdipoR1 nor AdipoR2 expression was modified in muscle...
  60. ncbi Fish protein hydrolysate reduces plasma total cholesterol, increases the proportion of HDL cholesterol, and lowers acyl-CoA:cholesterol acyltransferase activity in liver of Zucker rats
    Hege Wergedahl
    Institute of Medicine, Section of Medical Biochemistry, University of Bergen, Haukeland University Hospital, Norway
    J Nutr 134:1320-7. 2004
    ..In Zucker rats, FPH treatment affected the fatty acid composition in liver, plasma, and triacylglycerol-rich lipoproteins...
  61. pmc Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a neurotrophic role for insulin/IGF-I in diabetic autonomic neuropathy
    Robert E Schmidt
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Am J Pathol 163:21-8. 2003
    ....
  62. pmc Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy
    Yugal Behl
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    Am J Pathol 172:1411-8. 2008
    ....
  63. pmc A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats
    Xabier Buqué
    Department of Physiology, University of the Basque Country Medical School, Bilbao, Spain
    J Lipid Res 51:500-13. 2010
    ..analyses and comparative transcriptomics of isolated primary hepatocytes from livers of obese insulin-resistant Zucker rats (comprising mild to severe hepatic steatosis) and age-matched lean littermates, searching for novel genes ..
  64. ncbi Upregulation of angiotensin II type 1 receptor, inflammatory mediators, and enzymes of arachidonate metabolism in obese Zucker rat kidney: reversal by angiotensin II type 1 receptor blockade
    Zhong Gao Xu
    Gonda Diabetes Research Center, Beckman Research Institute of the City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Circulation 111:1962-9. 2005
    ..in obesity-induced renal disease, we examined the expression of key enzymes of arachidonate metabolism and inflammatory genes in untreated and losartan-treated obese Zucker rats, a model of obesity, insulin resistance, and renal injury.
  65. ncbi Fatty acid metabolism is enhanced in type 2 diabetic hearts
    Andrew N Carley
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
    Biochim Biophys Acta 1734:112-26. 2005
    ..Similar results have been obtained with human type 2 diabetic hearts, suggesting that pharmacological interventions that can reduce cardiac FA utilization may have beneficial effects on contractile function...
  66. ncbi Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R1202-12. 2009
    ..Upregulation of fatty acid transport increased red muscle, but not cardiac, triacylglycerol accumulation. White muscle lipid metabolism dysregulation was not observed...
  67. ncbi Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Am J Physiol Heart Circ Physiol 297:H125-33. 2009
    ..Based on the sophisticated method of P-V analysis, different characteristics of type 1 and type 2 diabetic cardiac dysfunction can be demonstrated...
  68. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
    ..This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes...
  69. ncbi A diet supplemented with husks of Plantago ovata reduces the development of endothelial dysfunction, hypertension, and obesity by affecting adiponectin and TNF-alpha in obese Zucker rats
    Milagros Galisteo
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    J Nutr 135:2399-404. 2005
    ..For this purpose, obese Zucker rats, a model of type 2 diabetes, and their lean littermates were studied...
  70. ncbi Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats
    Christine Y Christ
    Department of Physiology, University of Texas Health Sciences Center, San Antonio, Texas 78712, USA
    J Appl Physiol 92:736-44. 2002
    ..Obese Zucker rats were trained for 7 wk and studied by using the hindlimb-perfusion technique 24 h, 96 h, or 7 days after their ..
  71. ncbi Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance
    Gary J Litherland
    Division of Molecular Physiology, School of Life Sciences, Medical Sciences Institute Wellcome Trust Biocentre Complex, The University of Dundee, Dundee, UK
    Mol Cell Biochem 261:23-33. 2004
    ..Adipocytes from young obese (fa/fa), highly insulin-responsive Zucker rats contained considerably more plasma membrane GLUT5 than those from their lean counterparts (1...
  72. ncbi Differential structural and functional changes in penile and coronary arteries from obese Zucker rats
    Nuria Villalba
    Department of Physiology, Faculty of Pharmacy, Faculty of Veterinary Sciences, Universidad Complutense, Madrid, Spain
    Am J Physiol Heart Circ Physiol 297:H696-707. 2009
    ..PAs and CAs from 17- to 18-wk-old obese Zucker rats (OZRs) and from their control counterparts [lean Zucker rats (LZRs)] were mounted in microvascular myographs to ..
  73. ncbi Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability
    N D Oakes
    Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Diabetes 50:1158-65. 2001
    ..kg(-1).day(-1) or darglitazone 1.3 micromol.kg(-1).day(-1) for 3 weeks) on lipid metabolism in obese Zucker rats. In the basal 7-h fasted state, rosiglitazone (10 micromol.kg(-1)...
  74. ncbi Similar metabolic responses to calorie restriction in lean and obese Zucker rats
    Takuya Chiba
    Department of Investigative Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Mol Cell Endocrinol 309:17-25. 2009
    ..Thus, central NPY activation via peripheral signaling might play a crucial role in the effects of CR, even in insulin resistant and leptin receptor deficient conditions...
  75. ncbi Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario, Canada
    Behav Neurosci 119:1389-95. 2005
    ..To assess cognitive function, obese and lean Zucker rats were tested on a variable-interval delayed alternation test of learning and memory...
  76. ncbi Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats
    C Carpene
    Institut National de la Sante et de la Recherche Medicale, INSERM U858 équipe 3, Universite Paul Sabatier, IFR31, Centre Hospitalier Universitaire de Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Pharmacol Res 56:522-30. 2007
    ..p. administered for 3-5 weeks to obese Zucker rats at doses ranging from 20 to 300 micromol/kg...
  77. ncbi Flow-induced remodeling in resistance arteries from obese Zucker rats is associated with endothelial dysfunction
    Celine Bouvet
    Institut National de la Santé et de la Recherche U771, UMR Centre National de la Recherche Scientifique 6214, Universite d Angers, Angers, France
    Hypertension 50:248-54. 2007
    ..This dysfunction might have negative consequences in ischemic diseases in patients with obesity or metabolic syndrome...
  78. ncbi Angiotensin-converting enzyme inhibition and angiogenesis in myocardium of obese Zucker rats
    Jorge E Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, CONICET, Av Pueyrredon 1640, Buenos Aires 1118, Argentina
    Am J Hypertens 17:172-80. 2004
    ..to determine the possible beneficial effects of an ACE inhibitor perindopril on myocardial angiogenesis in an animal model of obesity, hypertension, and NIDDM, such as the obese Zucker rat (OZR) and control lean Zucker rats (LZR).
  79. ncbi Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats
    Gang Li
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida, USA
    Diabetes 52:1951-7. 2003
    ..suppresses food intake and weight gain and reduces visceral adiposity and hyperinsulinemia in leptin-resistant obese Zucker rats. The mechanisms may involve the sustained hypophagia and the augmentation of thermogenesis in BAT.
  80. ncbi Tesaglitazar, a dual peroxisome proliferator-activated receptor agonist (PPAR alpha/gamma), improves metabolic abnormalities and reduces renal injury in obese Zucker rats
    Jie Liao
    Section of Nephrology and Hypertension, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Nephron Exp Nephrol 114:e61-8. 2010
    ..receptor (PPAR)alpha/gamma agonist, on metabolic abnormalities and kidney injury in obese Zucker rats (OZR). Lean Zucker rats (LZR) and OZR were used as control groups...
  81. ncbi Impaired glucose metabolism in the heart of obese Zucker rats after treatment with phorbol ester
    D Morabito
    Division of Endocrinology and Diabetology, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    Int J Obes Relat Metab Disord 26:327-34. 2002
    To investigate the influence of obesity on the regulation of myocardial glucose metabolism following protein kinase C (PKC) activation in obese (fa/fa) and lean (Fa/?) Zucker rats.
  82. pmc Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats
    A Sanchez
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 159:604-16. 2010
    The aim of the current study was to investigate the role of arachidonic acid (AA) metabolism via cyclooxygenase (COX) in the endothelial dysfunction of penile arteries from pre-diabetic, obese Zucker rats (OZR).
  83. ncbi Leptin-receptor gene transfer into the arcuate nucleus of female Fatty zucker rats using recombinant adeno-associated viral vectors stimulates the hypothalamo-pituitary-gonadal axis
    Erin Keen-Rhinehart
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32601, USA
    Biol Reprod 71:266-72. 2004
    Fatty fa/fa Zucker rats with a missense mutation in the leptin receptor (OB-R) are obese and infertile with prolonged estrous cycles...
  84. ncbi Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats
    James D Fluckey
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Am J Physiol Endocrinol Metab 286:E753-8. 2004
    A recent report from our group demonstrated that insulin facilitates muscle protein synthesis in obese Zucker rats. The purpose of this study was to determine whether PKC, a probable modulator of insulin signal transduction and/or mRNA ..
  85. ncbi Increase of anti-oxidation by exercise in the liver of obese Zucker rats
    Shih Pei Chang
    Department of Physical Education and Department of Medical Technology, Chung Tai Institute of Health Sciences and Technology, Taiwan, ROC
    Clin Exp Pharmacol Physiol 31:506-11. 2004
    1. The effects of endurance training on the anti-oxidant status in diabetes were studied using obese Zucker rats. 2...
  86. ncbi Renal dopamine D(1) receptor dysfunction is acquired and not inherited in obese Zucker rats
    Anees Ahmad Banday
    Heart and Kidney Institute, University of Houston, Houston, TX 72204, USA
    Am J Physiol Renal Physiol 287:F109-16. 2004
    ..Previously, a defect was reported in renal D(1) receptor function in obese Zucker rats. In the present study, we sought to determine whether this D(1) receptor dysfunction is intrinsic in these ..
  87. ncbi The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats
    Antonia Serrano
    Fundacion IMABIS, Hospital Carlos Haya de Malaga, Laboratorio de Medicina Regenerativa, Avenida Carlos Haya 82, 7 a planta, E 29010 Malaga, Spain
    Neuropharmacology 54:226-34. 2008
    ..In the present study, we show the benefits of the treatment of obese Zucker rats with a combination of a cannabinoid CB1 receptor antagonist (Rimonabant) and oleoylethanolamide...
  88. ncbi Increased platelet activation in young Zucker rats with impaired glucose tolerance is improved by acarbose
    Andreas Schafer
    Department of Internal Medicine, Cardiology, University of Wurzburg, Wuerzburg, Germany
    Thromb Haemost 92:97-103. 2004
    ..Blood samples were collected from young lean (control) and obese Zucker rats, an established model of IGT, after single oral application of sucrose (4 g.kg-1)...
  89. ncbi Role of 5-HT1A receptors in the control of food intake in obese Zucker rats of different ages
    J P Voigt
    Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universitat Berlin, Koserstr 20, D 14195 Berlin, Germany
    Pharmacol Biochem Behav 72:403-9. 2002
    The present study describes the role of 5-HT1A receptors in the serotonergic control of food intake in obese Zucker rats of different ages...
  90. ncbi Central administration of a nitric oxide precursor abolishes both the hypothalamic serotonin release and the hypophagia induced by interleukin-1beta in obese Zucker rats
    Anderson Iuras
    Department of Physiology, Federal University of Sao Paulo, Rua Botucatu, 862 2 Andar, Vila Clementino, Sao Paulo, SP 04023 060, Brazil
    Regul Pept 124:145-50. 2005
    ..We addressed whether 5-HT is affected during IL-1beta-induced anorexia in obese Zucker rats and the influence of the central NO system on this IL-1beta/5-HT interaction...
  91. ncbi Physiological difference between obese (fa/fa) Zucker rats and lean Zucker rats concerning adiponectin
    Fumiki Oana
    Division of Discovery Research, Kissei Pharmaceutical Co Ltd, 4365 1, Hotaka, Nagano 399 8304, Japan
    Metabolism 54:995-1001. 2005
    ..The aim of this study was to examine the physiological difference concerning adiponectin between obese (fa/fa) Zucker rats and control lean Zucker rats...
  92. ncbi Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Am J Physiol Endocrinol Metab 288:E654-62. 2005
    ..The differing mechanisms of excess glucose production in these models were easily distinguished by integrated 2H and 13C NMR analysis of plasma glucose...
  93. pmc Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats
    G J Coope
    Cardiovascular and Gastrointestinal Department, AstraZeneca, Macclesfield, Cheshire, UK
    Br J Pharmacol 149:328-35. 2006
    ..Here we examine whether the lowering of blood glucose levels in the rat by small molecule glucokinase activators (GKAs) can be predicted from in vitro enzyme potencies and plasma compound exposure...
  94. ncbi Immunohistochemical localization of CB1 cannabinoid receptors in frontal cortex and related limbic areas in obese Zucker rats: effects of chronic fluoxetine treatment
    J Zarate
    Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Paseo de la Universidad 7, 01006 Vitoria, Spain
    Brain Res 1236:57-72. 2008
    ..CB1 cannabinoid receptor at the histochemical level in frontal cortex and related limbic areas of the obese Zucker rats. Higher levels of CB1 receptor expression in frontal, cingulated and piriform cortex, without differences in ..
  95. ncbi Fatty liver and insulin resistance in obese Zucker rats: no role for mitochondrial dysfunction
    Mélissa Flamment
    INSERM, U694, CHU Angers, 4 rue Larrey, F 49033 Angers, France
    Biochimie 90:1407-13. 2008
    ..mitochondrial function in fatty liver and insulin resistance state using isolated mitochondria from obese Zucker rats. We determined the relationship between ATP synthesis and oxygen consumption as well as the relationship ..
  96. ncbi Genotype and diet effects in lean and obese Zucker rats fed either safflower or coconut oil diets
    M P Cleary
    Hormel Institute, University of Minnesota, Austin 55912, USA
    Proc Soc Exp Biol Med 220:153-61. 1999
    Previously we reported that suckling lean heterozygous (FA/fa) Zucker rats had a number of adipose tissue measurements intermediate between those of homozygous lean (FA/FA) and obese (fa/fa) rats...
  97. ncbi Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Science, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Am J Physiol Heart Circ Physiol 290:H2066-74. 2006
    Previous studies have demonstrated that skeletal muscle perfusion is impaired in obese Zucker rats (OZR) under control conditions and with elevated metabolic demand versus responses in lean Zucker rats (LZR)...
  98. ncbi Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats
    Xueying Zhao
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Regul Integr Comp Physiol 288:R188-96. 2005
    ..arteries and 2) to determine the regulation of mesenteric artery cytochrome P-450 (CYP) enzymes in obese Zucker rats. Microvessels were incubated with arachidonic acid, and CYP enzyme activity was determined...
  99. ncbi Impaired in vivo venous constriction in conscious obese Zucker rats with metabolic syndrome
    Dongzhe Song
    Department of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada
    Naunyn Schmiedebergs Arch Pharmacol 373:451-6. 2006
    ..We examined if 16-week-old obese Zucker rats, relative to age-matched lean Zucker rats, had altered in vivo venoconstriction to noradrenaline...
  100. ncbi Detection of early atherosclerosis with radiolabeled monocyte chemoattractant protein-1 in prediabeteic Zucker rats
    F G Blankenberg
    Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
    Pediatr Radiol 31:827-35. 2001
    ..Injured vascular endothelial and smooth muscle cells selectively secrete MCP-1...
  101. ncbi Angiotensin II stimulates the reactivity of the pituitary-adrenal axis in leptin-resistant Zucker rats, thereby influencing the glucose utilization
    Helge Müller
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Am J Physiol Endocrinol Metab 293:E802-10. 2007
    ..b>Zucker rats were treated with ANG via subcutaneous minipumps (0, 0.9, and 9.0 mug/h; 4 wk)...

Research Grants63

  1. Insulin, Renal Sodium Transport and Blood Pressure
    Carolyn Ecelbarger; Fiscal Year: 2006
    ..regulation of all of the major renal sodium transporter proteins in normal rats and insulin resistant, obese Zucker rats. These studies will, hopefully, provide us with an enlightened understanding of the role of insulin in sodium ..
  2. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..b>Zucker rats model overfeeding and fructose-fed mice model increased consumption of fructose...
  3. Renal Angiotensin II Receptor Function in Obesity
    Tahir Hussain; Fiscal Year: 2013
    ..thus inhibiting proximal tubule Na,K-ATPase (NKA) activity and increasing urinary Na excretion in obese Zucker rats, a model of insulin resistance and hyperglycemia...
  4. Hepatic Insulin Gene Therapy in Swine
    Peter M Thule; Fiscal Year: 2013
    ..Moreover, HIGT is effective in lowering BG in hyperglycemic Zucker rats (unpublished data), an accepted model of type 2 DM...
  5. Macronutrient Regulation of Alternative Pre-mRNA Splicing
    Scot R Kimball; Fiscal Year: 2013
    ..as load-induced changes in troponin T pre-mRNA alternative splicing are impaired in obese, but not lean, Zucker rats, leading to inappropriate expression of troponin T isoforms...
  6. Gender and susceptibility to kidney damage in high BP
    Jane F Reckelhoff; Fiscal Year: 2010
    ..with hypertensive renal injury (rats with reduced renal mass on high salt diet), and men with type II diabetes (Zucker rats), using testosterone, the most commonly prescribed androgen for men...
  7. Fat, sweet taste, and cocaine reinforcement in obese and lean Zucker rats
    Kevin B Freeman; Fiscal Year: 2012
    ..These results will serve public health interests by providing information about reward vulnerabilities in the obese, which may then lead to more effective interventions in the treatment of obesity. ..
  8. Macronutrient Regulation of Alternative Pre-mRNA Splicing
    Scot R Kimball; Fiscal Year: 2012
    ..fat, as load-induced changes in troponin T pre-mRNA alternative splicing are impaired in obese, but not lean, Zucker rats, leading to inappropriate expression of particular troponin T isoforms...
  9. Mechanisms underlying altered automic regulation of blood pressure in obesity
    Ann M Schreihofer; Fiscal Year: 2010
    ..Obese Zucker rats (OZR) have autonomic deficits analogous to those observed in obese people: increased sympathetic nerve activity ..
  10. Regulation of thrombospondin-1 expression by glucose
    Olga I Stenina; Fiscal Year: 2010
    ..We recently reported that the expression of thrombospondin-1 (TSP-1) is strikingly elevated in large vessels of Zucker rats, an animal model of type 2 diabetes, both in basal conditions and in response to injury, suggesting a role for ..
  11. TRANSMEMBRANE SIGNALLING IN GENETIC OBESITY
    Kathryn LaNoue; Fiscal Year: 1993
    ..The insulin resistance, typical of skeletal muscle strips from obese Zucker rats, can be reversed with an A1 adenosine receptor antagonist and by prior treatment with pertussis toxin...
  12. UPPER GI TRACT MEDIATION OF THE SATIETY EFFECT OF FATS
    Danielle Greenberg; Fiscal Year: 1992
    ..Those fat stimuli that are most effective for inducing satiety and those mechanisms that are found to mediate the satiety response in Sprague Dawley rats will be subsequently tested in identical paradigms in lean and obese Zucker rats.
  13. HYPOTHALAMIC DYSFUNCTION
    Patrick Tso; Fiscal Year: 1999
    ..The Zucker obese rats have been used extensively in obesity research. Obesity in Zucker rats is an autosomal recessive trait caused by the mutated gene "fa"...
  14. ABNORMAL TRAFFICKING OF DIETARY FAT IN OBESITY
    Daniel Bessesen; Fiscal Year: 1999
    ..abnormality in the partitioning of dietary fat favoring storage over oxidation is present in genetically obese Zucker rats, and is accentuated when these rats lose weight...
  15. ADRENAL-PANCREAS INTERACTIONS: INTAKE & WEIGHT CONTROL
    THOMAS CASTONGUAY; Fiscal Year: 1993
    ..sufficient to produce Cushing's syndrome in intact Sprague-Dawley as well as heterozygote and homozygote lean Zucker rats will be determined...
  16. PHYSICAL ACTIVITY, PANCREATIC FUNCTION, AND OBESITY
    Judith Stern; Fiscal Year: 1992
    ..For these studies, we will use four animal models: 1) genetically obese Zucker rats (fafa), 2) genetically obese and diabetic Wistar Kyoto "fatty" rats (WKY-fafa), 3) genetically lean rats that ..
  17. ADRENOCORTICAL HORMONES IN OBESITY-RELATED HYPERTENSION
    ALEXANDER BROWNIE; Fiscal Year: 1991
    ..Adrenal and pituitary function will be examined in vivo and in vitro in fatty Zucker rats, Koletsky obese rats, obese ventromedial nucleus- lesioned rats, congenic spontaneous hypertensive/NIH ..
  18. ALTERED SEROTONIN IN OBESITY--ONTOGENY AND MECHANISMS
    Barbara Horwitz; Fiscal Year: 1999
    ..input to the ventromedial nucleus (VMN) of the hypothalamus which has been shown to be reduced in obese Zucker rats. The two major objectives of this proposal are related to the general theme that altered VMN serotonergic ..
  19. Pharyngeal mechanics by tagged MRI in a Zucker rat model
    MICHAEL BRENNICK; Fiscal Year: 2004
    ..technology that will enable us to examine pharyngeal wall tissue motion in anesthetized obese and non-obese Zucker rats, the obese genotype having a compromised pharyngeal airway similar to that in patients with OSA...
  20. CYTOKINE GENE THERAPY AND OBESITY
    Sergei Zolotukhin; Fiscal Year: 2001
    ..neurotrophic factor (CNTF) could be successfully used to maintain BW in lean and leptin-resistant obese fa/fa Zucker rats respectively...
  21. Obesity, hyperinsulinemia and colon cancer
    SHARON FLEMING; Fiscal Year: 2003
    ..Data from two studies using Zucker rats support this notion...
  22. CHOLECYSTOKININ AND FEEDING IN ZUCKER OBESE RATS
    Clifton Baile; Fiscal Year: 1980
    b>Zucker rats are used as a model for human obesity, a major health problem which occurs as result of an imbalance of energy intake and expenditure...
  23. Proatherogenic effect of thrombospondins in diabetes
    OLGA STENINA; Fiscal Year: 2005
    ..we recently reported that the expression of thrombospondin-1 (TSP-1) is strikingly elevated in large vessels of Zucker rats, an animal model of type 2 diabetes, both in basal conditions and in response to injury, suggesting a role for ..
  24. HYPOTHALAMIC STRUCTURE AND FUNCTION
    Judith Finkelstein; Fiscal Year: 1980
    ..The above studies will use genetically obese Zucker rats (fa/fa) and their non-obese littermates as subject...
  25. Renal Sodium Transport in the Obese Zucker Rat
    Carolyn Ecelbarger; Fiscal Year: 2007
    ..obese Zucker rat; 3) to determine the cellular location and sensitivity of the renal insulin receptor in obese Zucker rats relative to lean age-mates; 4) to determine whether treatment of insulin resistance with a PPAR-gamma agonist ..
  26. Antagonists of A2B Receptors Improve Insulin Sensitivity
    ROBERT FIGLER; Fiscal Year: 2005
    ..A few compounds will be evaluated in euglycemic clamp studies with Zucker rats. Our goal is to identify a lead compound that has good characteristics as a potential new drug...
  27. RENAL DOPAMINE RECEPTOR FUNCTION IN OBESE ZUCKER RATS
    Mustafa Lokhandwala; Fiscal Year: 2004
    ..cAMP and IP3) and thereby failed to inhibit Na,K-ATPase and Na,H-exchanger in the proximal tubules of obese Zucker rats (12 week old)...
  28. NMR od Muscle Perfusion and Oxygenation in Diabetes
    Pierre Carlier; Fiscal Year: 2003
    ..abnormalities in skeletal muscle perfusion and oxygenation will be monitored in ZDF rats as compared to lean Zucker rats, over a 20 week period...
  29. Antagonists of A2B Receptors Improve Insulin Sensitivity
    ROBERT FIGLER; Fiscal Year: 2001
    ..Blockade of A2B adenosine receptors (A2BARs) increases insulin sensitivity in insulin resistant obese Zucker rats by an effect on skeletal muscle...
  30. Skeletal Muscle Microcirculation in Obese Zucker Rats
    Jefferson Frisbee; Fiscal Year: 2009
    ..abstract_text> ..
  31. Antioxidants and Development of Diabetic Nephropathy
    SHARON INMAN; Fiscal Year: 2007
    ..fortified diet on renal function and the expression of nitric oxide synthases in diabetic male and female Zucker rats, and determine if there is a gender related response to therapy...
  32. Glycogen Synthase Kinase-3 and Muscle Insulin Resistance
    ERIK HENRIKSEN; Fiscal Year: 2007
    ..abstract_text> ..
  33. Mechanisms of Peripheral Microvascular Disease
    David Stepp; Fiscal Year: 2008
    ..abstract_text> ..
  34. Intermittent food restriction prevents mammary tumors
    MARGOT CLEARY; Fiscal Year: 2008
    ..Our long-term objectives are to establish nutrition intervention strategies applicable to humans and/or to provide insights leading to the development of chemopreventive agents to mimic this protective effect. [unreadable] [unreadable]..
  35. Insulin Control of Gene Transcription Through Sensitin
    BETTY VILLAFUERTE; Fiscal Year: 2008
    ..This study may lead to better understanding of insulin-regulated gene transcription, and may provide insights into linked to the pathogenesis of type 2 diabetes mellitus. ..
  36. IMPAIRED CORONARY ARTERY FUNCTION IN INSULIN RESISTANCE
    David Busija; Fiscal Year: 2003
    ..Findings from this project may provide important information that can be used in future studies to design treatments to prevent or abort the cardiovascular complications of insulin resistance. ..
  37. Intrarenal Augmentation of Angiotensinogen by Ang II
    Hiroyuki Kobori; Fiscal Year: 2010
    ..abstract_text> ..
  38. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 2002
    ..Positive results will confirm that chronic insulin resistance predisposes the microvasculature to abnormalities of endothelial function. However, antioxidants and inhibition of beta II isoenzymes of PKC may protect endothelial function. ..
  39. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
    ..Thus, we are poised to understand the pathogenesis and develop novel therapies for diabetic autonomic neuropathy. ..
  40. Arginine and Ovine Model for Fetal Growth Restriction
    Guoyao Wu; Fiscal Year: 2007
    ..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..
  41. Microvascular Regulation During Intestinal Absorption
    HAROLD G BOHLEN; Fiscal Year: 2010
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  42. Cerebrovascular Dysfunction in Insulin Resistance
    David Busija; Fiscal Year: 2004
    ..We believe that our studies will result in new and important findings that will lead to improved therapies to reduce morbidity and mortality in IR individuals. ..
  43. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..This mechanism may contribute to the ability of the coronary circulation to maintain cardiac perfusion and avoid ischemia during the early stages of coronary artery disease when NO-dependent dilation is compromised. ..
  44. NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEM
    Robert Schmidt; Fiscal Year: 2006
    ..The results of these experiments should provide insight not only into autonomic dysfunction, but into a variety of pathologic processes in which NAD is a prominent component. ..
  45. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2001
    ....
  46. RETINOID REGULATION OF TRANSGLUTAMINASE GENE EXPRESSION
    Peter Davies; Fiscal Year: 2001
    ..We will also investigate the role of direct and indirect effects on the activation of transglutaminase expression. These studies should provide new insights into the molecular mechanisms involved in retinoid - induced apoptosis in vivo. ..
  47. CONSTRUCTION OF ANIMAL FACILITY
    Peter Davies; Fiscal Year: 2002
    ..The CLAMC was initially accredited by the AAALAC International in 1978 and remains fully accredited today. The Director of the CLAMC reports directly to the Executive Vice President for Research of the UTHSC-H. ..
  48. EXERCISE AND SKELETAL MUSCLE FATTY ACID METABOLISM
    LORRAINE TURCOTTE; Fiscal Year: 2002
    ..For the first time, malonyl-CoA levels will be correlated to the rate of fatty acid oxidation in skeletal muscle. ..
  49. GENETIC DISSECTION OF VENTILATORY TRAITS
    Kingman Strohl; Fiscal Year: 2001
    ..Results will be relevant to illnesses known to result from, or be exacerbated by, poor or excessive ventilatory responses to environmental and pathophysiologic stresses. ..
  50. Role of Leucine Metabolism in Leucine Signaling
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2010
    ..The implication of our ongoing research is that blocking the first step in BCAA metabolism with a drug, or to a less extent increasing dietary BCAAs, will promote weight loss. ..
  51. Metabolic and Mitochondrial Defects of Islet beta-cells of MODY-3
    Gary Cline; Fiscal Year: 2009
    ..abstract_text> ..
  52. DYSREGULATION OF THE TAURINE TRANSPORTER IN DIABETES
    Martin Stevens; Fiscal Year: 2002
    ..As an alternative, if in aim 1 little correlation between hTT mRNA abundance and hTT activity is found, then glucose mediated post-translational modifications will be examined. ..
  53. ANTIHYPERTENSIVE MECHANISMS OF NEGATIVE ENERGY BALANCE
    J Overton; Fiscal Year: 2005
    ....
  54. Oxidative Stress Induces Apoptosis in Diabetic Neurons
    James Russell; Fiscal Year: 2006
    ....
  55. PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 2006
    ..These aims will be accomplished by using sound principles of experimentation and employing isolated islets that retain their in vivo sensitivity to glucose. ..
  56. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..abstract_text> ..
  57. Strategies to Identify In Vitro Islet Progenitors
    Susan Bonner Weir; Fiscal Year: 2007
    ..Identifying such cell(s) would then direct focus on the expansion and differentiation of that cell type to a sustainable source of new beta cells. [unreadable] [unreadable]..
  58. Repopulation of Liver Allografts by Recipients
    Zhaoli Sun; Fiscal Year: 2007
    ..Our studies may provide new insights into the mechanisms which promote tolerance and regeneration after liver transplantation and will provide the basis for the development of novel therapies. [unreadable] [unreadable] [unreadable]..
  59. CNS Stress Pathways and the Development of Acute HAAF
    Dianne Lattemann; Fiscal Year: 2003
    ..abstract_text> ..
  60. Type-2 Diabetes and Cardiac Dysfunction
    John Chatham; Fiscal Year: 2009
    ..This will facilitate the development of novel therapeutic interventions, designed to close the gap in mortality and morbidity between diabetic and non-diabetic patients with heart disease. ..