tsetse flies

Summary

Summary: Bloodsucking flies of the genus Glossina, found primarily in equatorial Africa. Several species are intermediate hosts of trypanosomes.

Top Publications

  1. ncbi Human African trypanosomiasis
    Reto Brun
    Swiss Tropical Institute, Basel, Switzerland
    Lancet 375:148-59. 2010
  2. pmc Wolbachia symbiont infections induce strong cytoplasmic incompatibility in the tsetse fly Glossina morsitans
    Uzma Alam
    Yale University, School of Public Health, Division of Epidemiology of Microbial Diseases, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002415. 2011
  3. pmc Obligate symbionts activate immune system development in the tsetse fly
    Brian L Weiss
    Division of Epidemiology of Microbial Diseases, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 188:3395-403. 2012
  4. pmc The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases
    Pere P Simarro
    World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, 1211 Geneva 27, Switzerland
    Int J Health Geogr 9:57. 2010
  5. pmc Microbiome influences on insect host vector competence
    Brian Weiss
    Department of Epidemiology and Public Health, Yale School of Public Health, New Haven, CT 06520, USA
    Trends Parasitol 27:514-22. 2011
  6. pmc Trypanosome infection establishment in the tsetse fly gut is influenced by microbiome-regulated host immune barriers
    Brian L Weiss
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America
    PLoS Pathog 9:e1003318. 2013
  7. pmc PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse's offspring
    Jingwen Wang
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:10552-7. 2012
  8. ncbi Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia
    Leyla Akman
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, Connecticut 06510, USA
    Nat Genet 32:402-7. 2002
  9. pmc Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly
    Lori Peacock
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, United Kingdom
    Proc Natl Acad Sci U S A 108:3671-6. 2011
  10. pmc Towards an optimal design of target for tsetse control: comparisons of novel targets for the control of Palpalis group tsetse in West Africa
    Jean Baptiste Rayaisse
    Centre International de Recherche Développement sur l Elevage en zone Subhumide CIRDES, Bobo Dioulasso, Burkina Faso
    PLoS Negl Trop Dis 5:e1332. 2011

Detail Information

Publications295 found, 100 shown here

  1. ncbi Human African trypanosomiasis
    Reto Brun
    Swiss Tropical Institute, Basel, Switzerland
    Lancet 375:148-59. 2010
    ..It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa...
  2. pmc Wolbachia symbiont infections induce strong cytoplasmic incompatibility in the tsetse fly Glossina morsitans
    Uzma Alam
    Yale University, School of Public Health, Division of Epidemiology of Microbial Diseases, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002415. 2011
    b>Tsetse flies are vectors of the protozoan parasite African trypanosomes, which cause sleeping sickness disease in humans and nagana in livestock...
  3. pmc Obligate symbionts activate immune system development in the tsetse fly
    Brian L Weiss
    Division of Epidemiology of Microbial Diseases, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 188:3395-403. 2012
    ..However, the molecular mechanisms that underlie this phenomenon are poorly understood. Adult tsetse flies (Glossina spp...
  4. pmc The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases
    Pere P Simarro
    World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, 1211 Geneva 27, Switzerland
    Int J Health Geogr 9:57. 2010
    ..For this reason WHO launched the HAT Atlas initiative, jointly implemented with the Food and Agriculture Organization of the United Nations, in the framework of the Programme Against African Trypanosomosis...
  5. pmc Microbiome influences on insect host vector competence
    Brian Weiss
    Department of Epidemiology and Public Health, Yale School of Public Health, New Haven, CT 06520, USA
    Trends Parasitol 27:514-22. 2011
    ..Here we provide an overview of the relationship between insect disease vectors, such as tsetse flies and mosquitoes, and their associated microbiome...
  6. pmc Trypanosome infection establishment in the tsetse fly gut is influenced by microbiome-regulated host immune barriers
    Brian L Weiss
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America
    PLoS Pathog 9:e1003318. 2013
    b>Tsetse flies (Glossina spp.) vector pathogenic African trypanosomes, which cause sleeping sickness in humans and nagana in domesticated animals...
  7. pmc PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse's offspring
    Jingwen Wang
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:10552-7. 2012
    ..Thus, PGRP-LB plays a pivotal role in tsetse's fitness by protecting symbiosis against host-inflicted damage during development and by controlling parasite infections in adults that can otherwise reduce host fecundity...
  8. ncbi Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia
    Leyla Akman
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, Connecticut 06510, USA
    Nat Genet 32:402-7. 2002
    ..b>Tsetse flies, the vectors of African trypanosomes, feed exclusively on blood and rely on one such intracellular microbe for ..
  9. pmc Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly
    Lori Peacock
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, United Kingdom
    Proc Natl Acad Sci U S A 108:3671-6. 2011
    ..This is evidence of conventional meiotic division in an excavate protist, and the functional conservation of the meiotic machinery in these divergent organisms underlines the ubiquity and basal evolution of meiosis in eukaryotes...
  10. pmc Towards an optimal design of target for tsetse control: comparisons of novel targets for the control of Palpalis group tsetse in West Africa
    Jean Baptiste Rayaisse
    Centre International de Recherche Développement sur l Elevage en zone Subhumide CIRDES, Bobo Dioulasso, Burkina Faso
    PLoS Negl Trop Dis 5:e1332. 2011
    b>Tsetse flies of the Palpalis group are the main vectors of sleeping sickness in Africa. Insecticide impregnated targets are one of the most effective tools for control...
  11. ncbi Tsetse flies: their biology and control using area-wide integrated pest management approaches
    Marc J B Vreysen
    Insect Pest Control Laboratory, Joint FAO IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna, Austria
    J Invertebr Pathol 112:S15-25. 2013
    b>Tsetse flies are the cyclical vectors of trypanosomes, the causative agents of 'sleeping sickness' or human African trypanosomosis (HAT) in humans and 'nagana' or African animal trypanosomosis (AAT) in livestock in Sub-saharan Africa...
  12. pmc Prospects for the development of odour baits to control the tsetse flies Glossina tachinoides and G. palpalis s.l
    J B Rayaisse
    Centre International de Recherche Développement sur l Elevage en zone Subhumide, Bobo Dioulasso, Burkina Faso, United Kingdom
    PLoS Negl Trop Dis 4:e632. 2010
    ....
  13. pmc Population genetics as a tool to select tsetse control strategies: suppression or eradication of Glossina palpalis gambiensis in the Niayes of Senegal
    Philippe Solano
    Institut de Recherche pour le Développement IRD Centre International de Recherche pour l Elevage en zones Subhumides CIRDES, UMR 177 IRD Centre de coopération Internationale en Recherche Agronomique pour le Développement CIRAD, CIRDES 01 BP 454, Bobo Dioulasso, Burkina Faso
    PLoS Negl Trop Dis 4:e692. 2010
    ..e. "eradication" versus "suppression." To inform this debate, we used population genetics to measure genetic differentiation between G. palpalis gambiensis from the Niayes and those from the southern tsetse belt (Missira)...
  14. pmc The obligate mutualist Wigglesworthia glossinidia influences reproduction, digestion, and immunity processes of its host, the tsetse fly
    Roshan Pais
    Yale School of Public Heath, Department of Epidemiology of Microbial Diseases, New Haven, CT 06520, USA
    Appl Environ Microbiol 74:5965-74. 2008
    b>Tsetse flies (Diptera: Glossinidae) are vectors for trypanosome parasites, the agents of the deadly sleeping sickness disease in Africa...
  15. ncbi Tsetse--A haven for microorganisms
    S Aksoy
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College St, 606 LEPH, New Haven, CT 06510, USA
    Parasitol Today 16:114-8. 2000
    ....
  16. pmc Improving the cost-effectiveness of visual devices for the control of riverine tsetse flies, the major vectors of human African trypanosomiasis
    Johan Esterhuizen
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 5:e1257. 2011
    Control of the Riverine (Palpalis) group of tsetse flies is normally achieved with stationary artificial devices such as traps or insecticide-treated targets...
  17. pmc Analysis of milk gland structure and function in Glossina morsitans: milk protein production, symbiont populations and fecundity
    Geoffrey M Attardo
    Yale School of Public Health, Department of Epidemiology and Microbial Diseases, 60 College Street, 606 LEPH New Haven, CT 06510, USA
    J Insect Physiol 54:1236-42. 2008
    ..We discuss the significance of the milk gland in larval nutrition and in transmission of symbiotic bacteria to developing offspring...
  18. pmc ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation
    Ines Subota
    Trypanosome Cell Biology Unit, Centre National de la Recherche Scientifique, Parasitology and Mycology Department, Institut Pasteur, 75015 Paris, France
    Mol Biol Cell 22:4205-19. 2011
    ....
  19. pmc Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission
    Jingwen Wang
    Department of Epidemiology of Microbial Diseases, Yale School of Public Heath, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:12133-8. 2009
    b>Tsetse flies, the sole vectors of African trypanosomes, have coevolved with mutualistic endosymbiont Wigglesworthia glossinidiae...
  20. pmc Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei
    Michael Oberle
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Pathog 6:e1001023. 2010
    ..trypanosomes are digenetic parasites that undergo part of their developmental cycle in mammals and part in tsetse flies. We established a novel technique to monitor the population dynamics of Trypanosoma brucei throughout its life ..
  21. pmc Implications of microfauna-host interactions for trypanosome transmission dynamics in Glossina fuscipes fuscipes in Uganda
    Uzma Alam
    Yale University School of Public Health, New Haven, Connecticut, USA
    Appl Environ Microbiol 78:4627-37. 2012
    b>Tsetse flies (Diptera: Glossinidae) are vectors for African trypanosomes (Euglenozoa: kinetoplastida), protozoan parasites that cause African trypanosomiasis in humans (HAT) and nagana in livestock...
  22. pmc Improving the cost-effectiveness of artificial visual baits for controlling the tsetse fly Glossina fuscipes fuscipes
    Jenny M Lindh
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 3:e474. 2009
    b>Tsetse flies, which transmit sleeping sickness to humans and nagana to cattle, are commonly controlled by stationary artificial baits consisting of traps or insecticide-treated screens known as targets...
  23. ncbi Tsetse-trypanosome interactions: rites of passage
    S C Welburn
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian, UK EH25 9RG
    Parasitol Today 15:399-403. 1999
    ..In this review, Susan Welburn and Ian Maudlin chart the progress of trypanosomes through the fly and identify some of the hazards faced by both parasite and fly that affect vector competence of tsetse...
  24. ncbi A phyto-sociological analysis of the distribution of riverine tsetse flies in Burkina Faso
    J Bouyer
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement, Département élevage et médecine vétérinaire, Montpellier, France
    Med Vet Entomol 19:372-8. 2005
    ..tachinoides in half-disturbed Sudanese gallery forest sites, confirming their high resilience to human-made changes. The importance of a detailed consideration of riverine ecotypes when predicting tsetse densities is discussed...
  25. pmc Standardizing visual control devices for tsetse flies: West African species Glossina tachinoides, G. palpalis gambiensis and G. morsitans submorsitans
    Jean Baptiste Rayaisse
    Centre International de Recherche Développement sur l Elevage en zone Subhumide CIRDES, Bobo Dioulasso, Burkina Faso
    PLoS Negl Trop Dis 6:e1491. 2012
    ..Biconical traps can be used for population monitoring, but a correction factor of 5-10 fold needs to be applied to captures to compensate for the poor trapping efficiency of this device for the three species...
  26. ncbi Correlation between structure, protein composition, morphogenesis and cytopathology of Glossina pallidipes salivary gland hypertrophy virus
    Henry M Kariithi
    Laboratory of Virology, Wageningen University, Wageningen, The Netherlands
    J Gen Virol 94:193-208. 2013
    ..This study provides important information about GpSGHV biology and suggests options for the development of future anti-GpSGHV strategies by interfering with virus-host interactions...
  27. pmc Climate, cattle rearing systems and African Animal Trypanosomosis risk in Burkina Faso
    Soumaïla Pagabeleguem
    Centre International de Recherche Développement sur l Elevage en zone Subhumide CIRDES, Bobo Dioulasso, Burkina Faso
    PLoS ONE 7:e49762. 2012
    In sub-Saharan countries infested by tsetse flies, African Animal Trypanosomosis (AAT) is considered as the main pathological constraint to cattle breeding...
  28. ncbi Refractoriness in tsetse flies (Diptera: Glossinidae) may be a matter of timing
    Dana Nayduch
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    J Med Entomol 44:660-5. 2007
    b>Tsetse flies (Diptera: Glossinidae: Glossina spp.) are vectors for African trypanosomiasis, a devastating disease that kills both people and animals in sub-Saharan Africa...
  29. pmc The life cycle of Trypanosoma (Nannomonas) congolense in the tsetse fly
    Lori Peacock
    School of Biological Sciences University of Bristol, UK
    Parasit Vectors 5:109. 2012
    ..brucei, knowledge of the corresponding developmental pathway in T. congolense is rudimentary. The recent publication of the genome sequence makes it timely to re-investigate the life cycle of T. congolense...
  30. pmc Global Wolbachia prevalence, titer fluctuations and their potential of causing cytoplasmic incompatibilities in tsetse flies and hybrids of Glossina morsitans subgroup species
    Daniela I Schneider
    Laboratories of Genome Dynamics, Department Cell and Developmental Biology, Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    J Invertebr Pathol 112:S104-15. 2013
    ..VNTR-based (Variable-Number-Tandem-Repeat) molecular screening tool for fingerprinting Wolbachia-infections in tsetse flies. The VNTR-141 locus provides reliable and concise differentiation between Wolbachia strains deriving from ..
  31. pmc Post eclosion age predicts the prevalence of midgut trypanosome infections in Glossina
    Deirdre P Walshe
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS ONE 6:e26984. 2011
    ..p.e. flies, increases teneral refractoriness. The importance of this phenomenon in disease biology in the field as well as the necessity of employing flies of consistent age in laboratory-based infection studies is discussed...
  32. pmc Tsetse salivary gland hypertrophy virus: hope or hindrance for tsetse control?
    Adly M M Abd-Alla
    Insect Pest Control Laboratory, Joint FAO IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria
    PLoS Negl Trop Dis 5:e1220. 2011
    MANY SPECIES OF TSETSE FLIES (DIPTERA: Glossinidae) are infected with a virus that causes salivary gland hypertrophy (SGH), and flies with SGH symptoms have a reduced fecundity and fertility...
  33. ncbi Grouping of trypanosome species in mixed infections in Glossina pallidipes
    M J Lehane
    School of Biological Sciences, University of Wales, Bangor, UK
    Parasitology 120:583-92. 2000
    ..05). If confirmed in other studies these findings have serious implications for our understanding of trypanosome epidemiology in tsetse flies, much of which is founded on data from dissection-based trypanosome identifications.
  34. pmc Progress towards the eradication of Tsetse from the Loos islands, Guinea
    Moise S Kagbadouno
    Programme National de Lutte contre la THA, Ministere de la Sante, Conakry, Guinée
    Parasit Vectors 4:18. 2011
    ..After baseline data collection, tsetse control began on the islands in 2006. On each of the three islands a specific combination of control methods was implemented according to the entomological situation found...
  35. ncbi How can tsetse population genetics contribute to African trypanosomiasis control?
    Philippe Solano
    Institut de Recherche pour le Développement IRD Centre International de Recherche pour l Elevage en zones Subhumides CIRDES, IRD UMR 177, CIRDES 01 BP 454 Bobo Dioulasso 01, Burkina Faso
    Trends Parasitol 26:255-63. 2010
    ..Implications of these studies for large-scale tsetse control programmes being undertaken in West Africa are important, particularly regarding control strategies (suppression or eradication)...
  36. pmc Mobile genetic element proliferation and gene inactivation impact over the genome structure and metabolic capabilities of Sodalis glossinidius, the secondary endosymbiont of tsetse flies
    Eugeni Belda
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Spain
    BMC Genomics 11:449. 2010
    ..Sodalis glossinidius, the secondary endosymbiont of tsetse flies, contains one of the few complete genomes of bacteria at the very beginning of the symbiotic association, ..
  37. pmc An insight into the sialome of Glossina morsitans morsitans
    Juliana Alves-Silva
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    BMC Genomics 11:213. 2010
    ..Adult tsetse flies feed exclusively on vertebrate blood and are important vectors of human and animal diseases...
  38. ncbi Population sizes and dispersal pattern of tsetse flies: rolling on the river?
    J Bouyer
    CIRAD, UMR CIRAD INRA Contrôle des maladies animales, Campus International de Baillarguet, F34398, Montpellier, France
    Mol Ecol 18:2787-97. 2009
    ..In these fragmented landscapes, tsetse flies displayed localized, small subpopulations with relatively short effective dispersal...
  39. pmc The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly
    Reuben Sharma
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Trends Parasitol 25:517-24. 2009
    ..However, investigation of trypanosomes in tsetse flies requires high resource investment and unusual patience; hence, many facets of trypanosome biology in the tsetse ..
  40. ncbi Proventriculus (cardia) plays a crucial role in immunity in tsetse fly (Diptera: Glossinidiae)
    Zhengrong Hao
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Insect Biochem Mol Biol 33:1155-64. 2003
    ..In several vector pathogen systems, including tsetse flies and African trypanosomes, stimulation of systemic responses prior to pathogen acquisition has been shown to ..
  41. pmc Tsetse immune system maturation requires the presence of obligate symbionts in larvae
    Brian L Weiss
    Department of Epidemiology and Public Health, Division of Epidemiology of Microbial Diseases, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Biol 9:e1000619. 2011
    ..This phenomenon provides evidence of yet another important physiological adaptation that further anchors the obligate symbiosis between tsetse and Wigglesworthia...
  42. pmc Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis
    Z Hao
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 98:12648-53. 2001
    b>Tsetse flies are the medically and agriculturally important vectors of African trypanosomes. Information on the molecular and biochemical nature of the tsetse/trypanosome interaction is lacking...
  43. ncbi Molecular phylogenetics of tsetse flies (Diptera: Glossinidae) based on mitochondrial (COI, 16S, ND2) and nuclear ribosomal DNA sequences, with an emphasis on the palpalis group
    N A Dyer
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, Merseyside, L3 5QA, UK
    Mol Phylogenet Evol 49:227-39. 2008
    Relationships of 13 species of the genus Glossina (tsetse flies) were inferred from mitochondrial (cytochrome oxidase 1, NADH dehydrogenase 2 and 16S) and nuclear (internal transcribed spacer 1 of rDNA) sequences...
  44. ncbi Less is more: restricted application of insecticide to cattle to improve the cost and efficacy of tsetse control
    S J Torr
    Natural Resources Institute, University of Greenwich, Chatham Maritime, UK
    Med Vet Entomol 21:53-64. 2007
    ..This would cut the cost of insecticide by 40%, improve efficacy by 27% and reduce the threats to non-target organisms and the enzootic stability of tick-borne diseases...
  45. ncbi Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessment
    Guy Caljon
    Unit of Cellular and Molecular Immunology, Flanders Interuniversity Institute for Biotechnology VIB, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Int J Parasitol 36:1025-35. 2006
    b>Tsetse flies (Glossina sp.) are blood-feeding dipteran insects that transmit African trypanosomes, parasites that are responsible for human sleeping sickness and veterinary infections...
  46. ncbi The tsetse fly Glossina fuscipes fuscipes (Diptera: Glossina) harbours a surprising diversity of bacteria other than symbionts
    Jenny M Lindh
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Antonie Van Leeuwenhoek 99:711-20. 2011
    Three different bacterial species are regularly described from tsetse flies. However, no broad screens have been performed to investigate the existence of other bacteria in this medically and agriculturally important vector insect...
  47. ncbi A changing environment and the epidemiology of tsetse-transmitted livestock trypanosomiasis
    Peter Van den Bossche
    Institute of Tropical Medicine, Animal Health Department, Nationalestraat 155, 2000 Antwerp, Belgium
    Trends Parasitol 26:236-43. 2010
    ..These changes in the dynamics of the epidemiology have an important impact on the factors that need to be considered when developing area-specific strategies for the future management of tsetse-transmitted livestock trypanosomiasis...
  48. ncbi A new Sodalis lineage from bloodsucking fly Craterina melbae (Diptera, Hippoboscoidea) originated independently of the tsetse flies symbiont Sodalis glossinidius
    Eva Novakova
    Faculty of Biological Sciences and Institute of Parasitology, Ceske Budejovice, Czech Republic
    FEMS Microbiol Lett 269:131-5. 2007
    Symbiotic bacterium closely related to the secondary symbiont of tsetse flies, Sodalis glossinidius, has been described from the bloodsucking fly Craterina melbae...
  49. ncbi Mapping African Animal Trypanosomosis risk from the sky
    Jeremy Bouyer
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement, Département élevage et médecine vétérinaire, Montpellier, France
    Vet Res 37:633-45. 2006
    ..The attempt of the present work was to assess the abundance of tsetse flies and AAT risk using remote sensing coupled to field environmental data, along a Mouhoun river section of 234 km ..
  50. ncbi Prolonged gene knockdown in the tsetse fly Glossina by feeding double stranded RNA
    D P Walshe
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA
    Insect Mol Biol 18:11-9. 2009
    ..Additionally, injection of tsetse flies often causes significant mortality...
  51. pmc The population structure of Glossina palpalis gambiensis from island and continental locations in Coastal Guinea
    Philippe Solano
    CIRDES IRD UMR 177 IRD CIRAD, Bobo Dioulasso, Burkina Faso
    PLoS Negl Trop Dis 3:e392. 2009
    ..These data are discussed with respect to the feasibility and sustainability of control strategies in those sites currently experiencing, or at risk of, sleeping sickness...
  52. ncbi Bacterial diversity associated with populations of Glossina spp. from Cameroon and distribution within the Campo sleeping sickness focus
    Anne Geiger
    UMR 177, IRD CIRAD, CIRAD TA A 17 G, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France
    Microb Ecol 62:632-43. 2011
    b>Tsetse flies were sampled in three villages of the Campo sleeping sickness focus in South Cameroon. The aim of this study was to investigate the flies' gut bacterial composition using culture-dependent techniques...
  53. pmc Tracking the feeding patterns of tsetse flies (Glossina genus) by analysis of bloodmeals using mitochondrial cytochromes genes
    Catherine N Muturi
    Molecular Biology and Biotechnology Department, International Centre of Insect Physiology and Ecology, Nairobi, Kenya
    PLoS ONE 6:e17284. 2011
    b>Tsetse flies are notoriously difficult to observe in nature, particularly when populations densities are low...
  54. pmc Infections with immunogenic trypanosomes reduce tsetse reproductive fitness: potential impact of different parasite strains on vector population structure
    Changyun Hu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS Negl Trop Dis 2:e192. 2008
    ..b>Tsetse flies are viviparous and have a low reproductive capacity, giving birth to only 6-8 progeny during their lifetime...
  55. ncbi Responses of Glossina morsitans morsitans to blends of electroantennographically active compounds in the odors of its preferred (buffalo and ox) and nonpreferred (waterbuck) hosts
    Nicholas K Gikonyo
    International Centre of Insect Physiology and Ecology, PO Box 30772, Nairobi, Kenya
    J Chem Ecol 29:2331-45. 2003
    ..The results lend further support to previous indications for the existence of a tsetse repellent blend in waterbuck body odor and additional attractive constituents in buffalo and ox body odors...
  56. pmc Tsetse EP protein protects the fly midgut from trypanosome establishment
    Lee R Haines
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Pathog 6:e1000793. 2010
    ..As starvation is a common field event, this fact may be of considerable importance in the epidemiology of African trypanosomiasis...
  57. ncbi A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly
    Brice Rotureau
    Trypanosome Cell Biology Unit, Institut Pasteur and CNRS, URA 2581, 25 rue du Docteur Roux, 75015 Paris, France
    Development 139:1842-50. 2012
    ..Dividing trypanosomes present in the salivary glands of infected tsetse flies were monitored by live video-microscopy and by quantitative immunofluorescence analysis using molecular markers ..
  58. ncbi Serratia glossinae sp. nov., isolated from the midgut of the tsetse fly Glossina palpalis gambiensis
    A Geiger
    UMR 177, IRD CIRAD, CIRAD TA A 17 G, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France
    Int J Syst Evol Microbiol 60:1261-5. 2010
    ..nov. (type strain C1(T) =DSM 22080(T) =CCUG 57457(T))...
  59. ncbi First isolation of Enterobacter, Enterococcus, and Acinetobacter spp. as inhabitants of the tsetse fly (Glossina palpalis palpalis) midgut
    Anne Geiger
    UMR 177, IRD CIRAD, CIRAD TA A 17 G, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France
    Infect Genet Evol 9:1364-70. 2009
    ..was the most frequently isolated. The role of these bacteria in the gut, in terms of vector competence of the tsetse fly, is discussed, as is the possibility of using these bacteria to produce in situ trypanolytic molecules...
  60. ncbi Tripartite interactions between tsetse flies, Sodalis glossinidius and trypanosomes--an epidemiological approach in two historical human African trypanosomiasis foci in Cameroon
    Oumarou Farikou
    University of Yaounde I, Faculty of Science, BP 812, Yaounde, Cameroon
    Infect Genet Evol 10:115-21. 2010
    ..This hypothesis was statistically tested and assessed, showing that S. glossinidius is potentially an efficient target for controlling tsetse fly vectorial competence and consequently sleeping sickness...
  61. ncbi Odor composition of preferred (buffalo and ox) and nonpreferred (waterbuck) hosts of some Savanna tsetse flies
    Nicholas K Gikonyo
    International Centre of Insect Physiology and Ecology, Nairobi, Kenya
    J Chem Ecol 28:969-81. 2002
    A previous study on the feeding responses of tsetse flies, Glossina morsitans morsitans, implicated the existence of allomonal barriers, both volatile and nonvolatile, on the nonpreferred host, waterbuck, Kobus defassa...
  62. pmc Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response
    Guy Caljon
    Unit of Cellular and Molecular Immunology, Flanders Interuniversity Institute for Biotechnology VIB, Vrije Universiteit Brussel VUB, Pleinlaan 2, B 1050 Brussels, Belgium
    Infect Immun 74:6324-30. 2006
    b>Tsetse flies (Glossina sp.) are the vectors that transmit African trypanosomes, protozoan parasites that cause human sleeping sickness and veterinary infections in the African continent...
  63. pmc Impact of salivary gland hypertrophy virus infection on the mating success of male Glossina pallidipes: consequences for the sterile insect technique
    Gratian N Mutika
    Insect Pest Control Laboratory, Joint FAO IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna, Austria
    PLoS ONE 7:e42188. 2012
    Many species of tsetse flies are infected by a virus (GpSGHV) that causes salivary gland hypertrophy (SGH). Female Glossina pallidipes (Austen) with SGH symptoms (SGH+) have reduced fecundity and SGH+ male G...
  64. ncbi Flying tryps: survival and maturation of trypanosomes in tsetse flies
    Naomi A Dyer
    Parasitology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Trends Parasitol 29:188-96. 2013
    ..Here we discuss parasite and fly factors determining trypanosome colonization of the tsetse, focusing mainly on the midgut...
  65. ncbi Sodalis gen. nov. and Sodalis glossinidius sp. nov., a microaerophilic secondary endosymbiont of the tsetse fly Glossina morsitans morsitans
    C Dale
    Division of Molecular Genetics, University of Glasgow, UK
    Int J Syst Bacteriol 49:267-75. 1999
    ..m. morsitans should be classified in a new genus Sodalis gen. nov., as Sodalis glossinidius gen. nov., sp. nov. Strain M1T is the type strain for this new species...
  66. ncbi Analysis of fat body transcriptome from the adult tsetse fly, Glossina morsitans morsitans
    G M Attardo
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Insect Mol Biol 15:411-24. 2006
    b>Tsetse flies (Diptera: Glossinidia) are vectors of pathogenic African trypanosomes...
  67. ncbi The relationship between rickettsia-like-organisms and trypanosome infections in natural populations of tsetse in Liberia
    I Maudlin
    Tsetse Research Laboratory, ODA University of Bristol, Langford, UK
    Trop Med Parasitol 41:265-7. 1990
    A survey of natural populations of tsetse flies for rickettsia-like-organisms (RLO) has been carried out in Liberia. A population of G.p...
  68. pmc The antiviral drug valacyclovir successfully suppresses salivary gland hypertrophy virus (SGHV) in laboratory colonies of Glossina pallidipes
    Adly M M Abd-Alla
    Insect Pest Control Laboratory, Joint FAO IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria
    PLoS ONE 7:e38417. 2012
    Many species of tsetse flies are infected with a virus that causes salivary gland hypertrophy (SGH) symptoms associated with a reduced fecundity and fertility...
  69. pmc Transcript expression analysis of putative Trypanosoma brucei GPI-anchored surface proteins during development in the tsetse and mammalian hosts
    Amy F Savage
    Division of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, USA
    PLoS Negl Trop Dis 6:e1708. 2012
    ..brucei surface proteins during the complete developmental cycle. This knowledge may form the foundation for the development of future novel transmission blocking strategies against metacyclic parasites...
  70. pmc Cryptic diversity within the major trypanosomiasis vector Glossina fuscipes revealed by molecular markers
    Naomi A Dyer
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 5:e1266. 2011
    ....
  71. pmc Attenuation of the sensing capabilities of PhoQ in transition to obligate insect-bacterial association
    Mauricio Henriques Pontes
    Department of Biology, University of Utah, Salt Lake City, Utah, USA
    PLoS Genet 7:e1002349. 2011
    ..The loss of PhoQ's sensory capability is predicted to represent a novel adaptation to the static symbiotic lifestyle, allowing S. glossinidius to constitutively express genes that facilitate resistance to host derived AMPs...
  72. ncbi Shoo fly, don't bother me! Efficacy of traditional methods of protecting cattle from tsetse
    S J Torr
    Agriculture, Health and Environment Department, Natural Resources Institute, University of Greenwich, Chatham Maritime, UK
    Med Vet Entomol 25:192-201. 2011
    ..The practical benefits and difficulties of using repellents and/or housing to manage trypanosomiases are discussed...
  73. pmc Where, when and why do tsetse contact humans? Answers from studies in a national park of Zimbabwe
    Stephen J Torr
    Natural Resources Institute, University of Greenwich, Chatham, United Kingdom
    PLoS Negl Trop Dis 6:e1791. 2012
    ..Hence, it takes a long time to catch many savannah tsetse from people, which in turn means that studies of the nature of contact between savannah tsetse and humans, and the ways of minimizing it, have been largely neglected...
  74. ncbi Thermal tolerance in a south-east African population of the tsetse fly Glossina pallidipes (Diptera, Glossinidae): implications for forecasting climate change impacts
    John S Terblanche
    Centre for Invasion Biology, Department of Botany and Zoology, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa
    J Insect Physiol 54:114-27. 2008
    ....
  75. pmc Characterisations of odorant-binding proteins in the tsetse fly Glossina morsitans morsitans
    Renhu Liu
    Department of Biological Chemistry, Harpenden, UK
    Cell Mol Life Sci 67:919-29. 2010
    ..Sequence comparisons with OBPs of other Dipterans identified several homologs to sex pheromone-binding proteins and OBPs of Drosophila melanogaster...
  76. ncbi African trypanosomes: celebrating diversity
    Emily R Adams
    Koninklijk Instituut voor de Tropen KIT Biomedical Research, Amsterdam 1105 AZ, Netherlands
    Trends Parasitol 26:324-8. 2010
    ..We should first acknowledge that these novel trypanosomes exist and then take steps to investigate their host range, pathogenicity to livestock and response to chemotherapy...
  77. pmc Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania
    Harriet K Auty
    Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
    PLoS Negl Trop Dis 6:e1501. 2012
    ..b. rhodesiense in tsetse are applied and interpreted inconsistently, and discrepancies between studies suggest this value is not consistently estimated even to within an order of magnitude...
  78. ncbi Integrated control of vector-borne diseases of livestock--pyrethroids: panacea or poison?
    Mark C Eisler
    University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Trends Parasitol 19:341-5. 2003
    ..Recent research to identify, quantify and to develop strategies to avoid these effects are highlighted...
  79. ncbi Tsetse fly blood meal modification and trypanosome identification in two sleeping sickness foci in the forest of southern Cameroon
    Oumarou Farikou
    University of Yaounde I, Faculty of Science, P O Box 812, Yaounde, Cameroon
    Acta Trop 116:81-8. 2010
    The blood meal origins of 222 tsetse flies (213 Glossina palpalis palpalis, 7 Glossina pallicera pallicera, one Glossina nigrofusca and one Glossina caliginea) caught in 2008 in two Human African trypanosomiasis foci (Bipindi and Campo) ..
  80. ncbi New Rickettsia sp. in tsetse flies from Senegal
    O Mediannikov
    Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes Université de la Méditerranée, Marseille, France
    Comp Immunol Microbiol Infect Dis 35:145-50. 2012
    b>Tsetse flies are blood-sucking insects transmitting African trypanosomiasis...
  81. pmc Contrasting population structures of two vectors of African trypanosomoses in Burkina Faso: consequences for control
    Naférima Koné
    Unité de Formation et de Recherche Biosciences, University of Abidjan, Abidjan, Ivory Coast
    PLoS Negl Trop Dis 5:e1217. 2011
    ..A wide variety of control tactics is available to manage these vectors, but their removal will in most cases only be sustainable if the control effort is targeting an entire tsetse population within a circumscribed area...
  82. pmc Polyandry is a common event in wild populations of the Tsetse fly Glossina fuscipes fuscipes and may impact population reduction measures
    Angelica Bonomi
    Department of Animal Biology, University of Pavia, Pavia, Italy
    PLoS Negl Trop Dis 5:e1190. 2011
    ..f. fuscipes has not been investigated in the laboratory or in the wild. Interest in assessing the presence of remating in Ugandan populations is driven by the fact that eradication of this species is at the planning stage in this country...
  83. ncbi A theoretical study of the invasion of cleared areas by tsetse flies (Diptera: Glossinidae)
    J W Hargrove
    c o Tsetse Control Branch, Box CY52, Causeway, Harare, Zimbabwe
    Bull Entomol Res 90:201-9. 2000
    Large-scale eradication campaigns against tsetse flies Glossina spp. are giving way to smaller operations aimed at disease and vector containment. There has been little discussion of the effects of these changes in policy...
  84. ncbi Insecticide-treated cattle against tsetse (Diptera: Glossinidae): what governs success?
    J W Hargrove
    Tsetse Control Branch, Box CY52, Causeway, Harare, Zimbabwe
    Bull Entomol Res 93:203-17. 2003
    ....
  85. pmc Temporal stability of Glossina fuscipes fuscipes populations in Uganda
    Richard Echodu
    Faculty of Science, Gulu University, Uganda
    Parasit Vectors 4:19. 2011
    ..f. fuscipes distributed across southeastern Uganda, including a zone of contact between two historically isolated lineages. A total of 667 tsetse flies were genotyped at 16 microsatellite loci and at one mitochondrial locus.
  86. ncbi Predicting the distribution of tsetse flies in West Africa using temporal Fourier processed meteorological satellite data
    D J Rogers
    Department of Zoology, University of Oxford
    Ann Trop Med Parasitol 90:225-41. 1996
    ..application of remotely-sensed, satellite data to the problems of predicting the distribution and abundance of tsetse flies in West Africa. The distributions of eight species of tsetse, Glossina morsitans, G. longipalpis, G...
  87. ncbi Tsetse fly host preference from sleeping sickness foci in Cameroon: epidemiological implications
    G Simo
    Medical Research Centre, Institute of Medical Research and Medicinal Plants Studies IMPM MINRESI, P O Box 6163 Yaoundé, Cameroon
    Infect Genet Evol 8:34-9. 2008
    ..For the whole study, 4929 tsetse flies were caught: 3933 (79.8%) Glossina palpalis palpalis, 626 (12.7%) Glossina pallicera pallicera, 276 (5...
  88. ncbi Dynamics of the salivary gland hypertrophy virus in laboratory colonies of Glossina pallidipes (Diptera: Glossinidae)
    Adly M M Abd-Alla
    Insect Pest Control Laboratory, Joint FAO IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna, Austria
    Virus Res 150:103-10. 2010
    Many species of tsetse flies are infected by a virus that causes salivary gland hypertrophy (SGH) and the virus isolated from Glossina pallidipes (GpSGHV) has recently been sequenced. Flies with SGH have a reduced fecundity and fertility...
  89. ncbi Stratified entomological sampling in preparation for an area-wide integrated pest management program: the example of Glossina palpalis gambiensis (Diptera: Glossinidae) in the Niayes of Senegal
    Jeremy Bouyer
    Unité Mixte de Recherche Centre de Coopération Internationale en Recherche Agronomique pour le Développement Institut National de la Recherche Agronomique Contrôle des Maladies Animales, Campus International de Baillarguet, F34398, Montpellier, France
    J Med Entomol 47:543-52. 2010
    ..The final size of the control area will be decided based on the entomological collection data. This entomological sampling procedure might be used for other vector or pest control scenarios...
  90. ncbi Is there safety in numbers? The effect of cattle herding on biting risk from tsetse flies
    S J Torr
    Natural Resources Institute, University of Greenwich, Greenwich, U K
    Med Vet Entomol 21:301-11. 2007
    ....
  91. pmc Genetic diversity and population structure of Glossina pallidipes in Uganda and western Kenya
    Johnson O Ouma
    Trypanosomiasis Research Centre, Kenya Agricultural Research Institute, Kikuyu, Kenya
    Parasit Vectors 4:122. 2011
    ..It is unknown whether the G. pallidipes belt in southeastern Uganda extends into western Kenya. We investigated the genetic diversity and population structure of G. pallidipes in Uganda and western Kenya...
  92. pmc Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections
    B Bucheton
    Institut de recherche pour le developpement IRD, Unité Mixte de Recherche IRD CIRAD 177, Campus International de Baillarguet, Montpellier, France
    Parasite Immunol 33:438-47. 2011
    ..b. gambiense in humans and on the host factors involved. The consequences/impacts on HAT epidemiology resulting from this diversity are also discussed with regard to implementing sustainable HAT control strategies...
  93. pmc Activation of endocytosis as an adaptation to the mammalian host by trypanosomes
    Senthil Kumar A Natesan
    The Molteno Building, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Eukaryot Cell 6:2029-37. 2007
    ..These data suggest that high-level endocytosis in Trypanosoma brucei is an adaptation required for viability in the mammalian host...
  94. ncbi Controlling sleeping sickness - a review
    S C Welburn
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Summerhall, Edinburgh, EH9 1QH
    Parasitology 136:1943-9. 2009
    ....
  95. pmc The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly
    A Acosta-Serrano
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:1513-8. 2001
    ..method to analyze the appearance of different procyclins during the establishment of midgut infections in tsetse flies. We found that different procyclin gene products are expressed in an orderly manner...
  96. ncbi Quantitative PCR analysis of the salivary gland hypertrophy virus (GpSGHV) in a laboratory colony of Glossina pallidipes
    Adly M M Abd-Alla
    Entomology Unit, FAO IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories Seibersdorf, A 2444 Seibersdorf, Austria
    Virus Res 139:48-53. 2009
    Many species of tsetse flies can be infected by a virus that causes salivary gland hypertrophy (SGH) and virus isolated from Glossina pallidipes (GpSGHV) has recently been sequenced. Flies having SGH have a reduced fecundity and fertility...
  97. ncbi The use of aerial spraying to eliminate tsetse from the Okavango Delta of Botswana
    P M Kgori
    Tsetse Control Division, Maun, Botswana
    Acta Trop 99:184-99. 2006
    ....
  98. ncbi An antimicrobial peptide with trypanocidal activity characterized from Glossina morsitans morsitans
    Youjia Hu
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University, School of Medicine, 60 College St, 606 LEPH, New Haven, CT 06510, USA
    Insect Biochem Mol Biol 35:105-15. 2005
    b>Tsetse flies (Diptera:Glossinidae) are vectors of African trypanosomes, the protozoan agents of devastating diseases in humans and animals...
  99. pmc Interspecific transfer of bacterial endosymbionts between tsetse fly species: infection establishment and effect on host fitness
    Brian L Weiss
    Department of Epidemiology and Public Health, Yale University School of Medicine, LEPH 606, 60 College Street, New Haven, CT 06510, USA
    Appl Environ Microbiol 72:7013-21. 2006
    b>Tsetse flies (Glossina spp.) can harbor up to three distinct species of endosymbiotic bacteria that exhibit unique modes of transmission and evolutionary histories with their host...
  100. ncbi Effects of flow rate and temperature on cyclic gas exchange in tsetse flies (Diptera, Glossinidae)
    John S Terblanche
    Department of Conservation Ecology and Entomology, Faculty of AgriSciences, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa
    J Insect Physiol 56:513-21. 2010
    ..This is unusual among insects showing CGE or DGE patterns because increases in metabolic rate are usually modulated by increases in frequency, but either no change or a decline in burst volume...
  101. ncbi Development of a non-destructive PCR method for detection of the salivary gland hypertrophy virus (SGHV) in tsetse flies
    Adly Abd-Alla
    Entomology Unit, FAO IAEA Agriculture and Biotechnology Laboratory, A 2444 Seibersdorf, Austria
    J Virol Methods 139:143-9. 2007
    A PCR based diagnostic method to detect salivary gland hypertrophy virus (SGHV) in tsetse flies is described. Two sets of primers GpSGHV1F/GpSGHV1R and GpSGHV2F/GpSGHV2R were selected from a virus-specific sequence...

Research Grants26

  1. Ecology, genetics and physiology of insect vectors
    Elliot Krafsur; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by the applicant): Tsetse flies, Glossina spp., are obligate blood feeders and the vectors in Africa of the trypanosomes that cause sleeping sickness in people and 'nagana' in cattle...
  2. Lipid metabolism during tsetse reproduction
    JOSH B BENOIT; Fiscal Year: 2013
    ..b>Tsetse flies are the sole vector of African sleeping sickness...
  3. Genes and Neural Circuits Mediating Avoidance Behavior
    Greg S B Suh; Fiscal Year: 2013
    ..the mechanism by which their neural circuits trigger behavioral responses to these stimuli would help us develop better strategies to prevent transmission of insect-born diseases by mosquitoes, tsetse flies, and other pathogenic insects.
  4. Targeting Trypanosoma brucei S-adenosylmethionine decarboxylase in Drug Discovery
    NAHIR VELEZ; Fiscal Year: 2012
    ..sickness, is caused by single-celled parasites, Trypanosoma brucei, which are transmitted to humans by infected tsetse flies. Trypanosomiasis has a profound impact on the health of a large number of people in sub-Saharan Africa...
  5. Molecular and functional characterization of olfaction genes in tsetse flies
    Serap Aksoy; Fiscal Year: 2013
    ....
  6. Evidence based control strategies of Sleeping Sickness vectors
    Serap Aksoy; Fiscal Year: 2012
    ..HAT disease belts (gambiense and rhodesiense) in Uganda with a focus on population and evolutionary genetics of tsetse flies and their parasites and endosymbionts. The co- investigator of this FIRCA, Dr...
  7. The role of PhoP-PhoQ in an insect-bacterial symbiosis
    Colin Dale; Fiscal Year: 2013
    ..These mutants will then be assessed for their ability to initiate and maintain symbiotic interactions in tsetse flies. The primary goal of the proposed research is to understand how the functions of PhoP-PhoQ have been modulated ..
  8. Sodalis glossinidius iron acquisition
    LAURA JANE RUNYEN-JANECKY; Fiscal Year: 2012
    ..In Specific Aims 1 and 2, the ability of the Sodalis heme and achromobactin transporter mutants to grow in tsetse flies and in insect culture will be examined to test hypotheses related to the question of which Sodalis iron ..
  9. Symbiosis and Immunity in the Tsetse Fly
    Brian L Weiss; Fiscal Year: 2013
    ..Specifically, when immature tsetse flies develop in the absence of their endogenous microbiota, subsequent 'aposymbiotic'adults are highly ..
  10. Dynamic Ecological Simulation Model of Tsetse Transmitted Trypanosomosis in Kenya
    Joseph P Messina; Fiscal Year: 2010
    ..change, land use and cover change, social systems, and ecological disturbance on the ecological distribution of tsetse flies and African Trypanosomiasis or sleeping sickness across Kenya...
  11. Regulation of mRNA Turnover in Trypanosomes
    Vivian Bellofatto; Fiscal Year: 2003
    ..African trypanosomiasis is spread to humans by the bite of tsetse flies that harbor the Trypanosoma brucei subspecies...
  12. HOST-REGULATED DEVELOPMENT IN ARTHROPOD VECTORS
    Dov Borovsky; Fiscal Year: 1993
    ..Such diverse arthropods as mosquitoes and ticks, tsetse flies and bugs, sandflies and fleas and vectors of plant as well as animal infections have been the subjects of these ..
  13. Investigation of iron acquisition genes in Sodalis glossinidius using new tools.
    Laura Runyen Janecky; Fiscal Year: 2009
    ..In specific aim 2, the ability of the Sodalis hemS and achromobactin mutants to grow in tsetse flies and in insect culture will be examined to determine which Sodalis iron acquisition genes are important for ..
  14. INTERACTION OF TSETSE--ITS SYMBIONTS AND TRYPANOSOMES
    Serap Aksoy; Fiscal Year: 2001
    b>Tsetse flies are important vectors of disease for both humans and livestock, transmitting the protozoan parasites African trypanosomes...
  15. Adaptive evolution of pathogenesis towards symbiosis
    Serap Aksoy; Fiscal Year: 2009
    ..b>Tsetse flies are the sole vectors of African trypanosomes, (Trypanosoma spp...
  16. Trypanosome gene expression in tsetse
    Serap Aksoy; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  17. Gene expression in commensal tsetse symbionts
    Brian Weiss; Fiscal Year: 2007
    ..These 'paratransgenic' flies and their offspring will then be monitored for changes in fitness, stability of recombinant protein expression and trypanosome vectorial capacity. ..
  18. MECHANISMS AND CONSEQUENCES OF DELETERIOUS EVOLUTION IN BACTERIA
    Jennifer J Wernegreen; Fiscal Year: 2010
    ..By deciphering fundamental mechanisms that influence bacterial genome evolution, this study will contribute to a predictive framework for understanding how microbes evolve. ..
  19. Molecular Analysis of Tsetse Fly Reproduction
    Geoffrey Attardo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. A Novel Virus that Infects & Sterilizes Insect Vectors of Human Disease
    Drion Boucias; Fiscal Year: 2008
    ..for utilizing the SGHVs as birth control for house flies and as vehicles to deliver paratransgenes into tsetse flies and for developing the house fly as a model system to screen antiviral therapies and to teach virus biology...
  21. Role of Shigella two component regulation systems in intracellular adaptation
    Laura Runyen Janecky; Fiscal Year: 2007
    ..The research described in this proposal will be useful for designing more effective therapies and will yield information applicable to other similar pathogens. [unreadable] [unreadable] [unreadable] [unreadable]..
  22. DEVELOPMENT OF GENETIC TOOLS FOR TRYPANOSOMA BRUCEI
    GEORGE CROSS; Fiscal Year: 2006
    ..abstract_text> ..
  23. INVASION BIOLOGY OF AEDES ALBOPICTUS
    LEON LOUNIBOS; Fiscal Year: 2009
    ..Blood meal identifications and sugar content of wild-caught specimens will determine vertebrate hosts and nectar feeding, and effects of blood and sugar on adult fitness will be evaluated experimentally. ..
  24. Telomere structure and function in Trypanosoma brucei
    GEORGE CROSS; Fiscal Year: 2005
    ..There are significant similarities between the telomeres of trypanosomes and humans, so trypanosomes would be a useful model in which to study events that are relevant to human aging and cancer. ..